1,067 Matching Annotations
  1. Jul 2020
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    Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
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    biorxiv.org/content/10.1101/2020.02.03.931576v1
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    Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress
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    biorxiv.org/content/10.1101/836015v1
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    miR-9 mediated noise optimization of the her6 oscillator is needed for cell state progression in the Zebrafish hindbrain
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    biorxiv.org/content/10.1101/608604v1
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    ROS production by localized SCHENGEN receptor module drives lignification at subcellular precision
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    biorxiv.org/content/10.1101/818997v1
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    Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling
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    biorxiv.org/content/10.1101/740472v1
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    The outer membrane lipoprotein NlpI nucleates hydrolases within peptidoglycan multi-enzyme complexes in Escherichia coli
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    biorxiv.org/content/10.1101/609503v1
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    Distinct Regulaton of Bioenergetics and Translation by Gp I mGluRs and NMDARs
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    biorxiv.org/content/10.1101/552638v4
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    CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering
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    biorxiv.org/content/10.1101/2020.02.26.965889v1
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    Co-catabolism of arginine and succinate drives symbiotic nitrogen fixation
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    biorxiv.org/content/10.1101/741314v2
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    A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes
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    biorxiv.org/content/10.1101/2020.01.02.893370v1
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    An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation
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    biorxiv.org/content/10.1101/561464v2
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    The multi PAM2 protein Upa2 functions as novel core component of endosomal mRNA transport
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    biorxiv.org/content/10.1101/455378v2
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    Plant photoreceptors and their signaling components compete for binding to the ubiquitin ligase COP1 using their VP-peptide motifs
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    biorxiv.org/content/10.1101/568618v1
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    The Notch and EGFR signaling regulate caspase inhibitor Diap1 to match supply with intestinal demand
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    biorxiv.org/content/10.1101/493528v1
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    Beyond the seed: structural basis for supplementary mircoRNA targeting
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    biorxiv.org/content/10.1101/476960v1
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    A SKI subcomplex specifically required for the degradation of ribosome-free RNA regions
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    biorxiv.org/content/10.1101/409490v2
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    PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours
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    biorxiv.org/content/10.1101/757419v1
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    Control of the Endo-Lysosome Homeostasis by the Paracaspase MALT1 regulates Glioma Cell Survival
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    biorxiv.org/content/10.1101/582221v1
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    Hippo Pathway Deregulation Drives Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
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    biorxiv.org/content/10.1101/390849v1
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    MTA proteins act redundantly within the NuRD complex to ensure fidelity of ES cell lineage commitment
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    biorxiv.org/content/10.1101/362988v2
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    EZH2 co-opts gain-of-function p53 mutants to promote cancer growth and metastasis
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    biorxiv.org/content/10.1101/298737v1
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    Radial F-actin Organization During Early Neuronal Development
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    biorxiv.org/content/10.1101/372813v2
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    Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts
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    biorxiv.org/content/10.1101/755652v1
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    ESCRT machinery mediates selective microautophagy of endoplasmic reticulum
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    biorxiv.org/content/10.1101/661306v1
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    TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease
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    biorxiv.org/content/10.1101/634519v1
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    Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor
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    biorxiv.org/content/10.1101/682302v1
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    Digitalizing heterologous gene expression in Gram-negative bacteria with a portable on/off module
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    biorxiv.org/content/10.1101/783506v1
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    Characterisation of the c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication
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    biorxiv.org/content/10.1101/634592v1
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    Machine characterization of rat toxin responses identifies disease states, tolerance mechanisms and organ to whole-body communication
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    biorxiv.org/content/10.1101/322446v1
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    The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae
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    biorxiv.org/content/10.1101/487439v1
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    Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion
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    biorxiv.org/content/10.1101/646463v1
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    Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency
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    biorxiv.org/content/10.1101/679449v1
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    Robust and conserved stochastic self-assembly mechanism for dynamic ParB-parS partition complexes on bacterial chromosomes and plasmids
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    biorxiv.org/content/10.1101/345066v1
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    Dynamic interactions of lymphatic vessels at the hair follicle stem cell niche during hair regeneration
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    biorxiv.org/content/10.1101/548768v1
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    Temporal perturbation of Erk dynamics reveals network architecture of FGF2-MAPK signaling
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    biorxiv.org/content/10.1101/629287v1
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    Pathogen-induced pH changes regulate the growth-defense balance of plants
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    biorxiv.org/content/10.1101/550491v1
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    Targeted gene correction of FKRP by CRISPR/Cas9 restores functional glycosylation of α-dystroglycan in cortical neurons derived from human induced pluripotent stem cells
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    biorxiv.org/content/10.1101/101352v1
  39. Jun 2020
  40. www.biorxiv.org www.biorxiv.org
    Plant-microbe co-evolution: allicin resistance in a Pseudomonas fluorescens strain (PfAR-1) isolated from garlic
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    biorxiv.org/content/10.1101/769265v1
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    Ubiquitin and SUMO conjugation as biomarkers of Acute Myeloid Leukemias response to chemotherapies
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    biorxiv.org/content/10.1101/825182v1
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    Dynamic changes in the regulatory T cell heterogeneity and function by murine IL-2 mutein
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    biorxiv.org/content/10.1101/669978v1
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    BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
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    biorxiv.org/content/10.1101/2019.12.13.876268v2
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    The structure of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR-fold
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    biorxiv.org/content/10.1101/709915v1
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    A natural variant of the sole pyruvate kinase of fission yeast lowers glycolytic flux triggering increased respiration and oxidative-stress resistance but decreased growth
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    biorxiv.org/content/10.1101/770768v1
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    Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis
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    biorxiv.org/content/10.1101/634501v1
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    A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
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    biorxiv.org/content/10.1101/2020.04.24.059840v1
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    Regulatory kinase genetic interaction profiles differ between environmental conditions and cellular states
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    biorxiv.org/content/10.1101/735720v1
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    Impact of C-terminal amino acid composition on protein expression in bacteria
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    biorxiv.org/content/10.1101/751305v1
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    Metabolic Energy Sensing by Mammalian CLC Anion/Proton Exchangers
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    biorxiv.org/content/10.1101/545368v1
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    https://doi.org/10.1101/2020.03.13.991455
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    Precursor miRNAs are trafficked along axons associated with vesicles and locally processed to regulate growth cone steering
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    biorxiv.org/content/10.1101/470393v1
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    Gi-Coupled Receptor Activation Potentiates Piezo2 Currents via Gβγ
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    biorxiv.org/content/10.1101/722637v1
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    The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours
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    Translational efficiency across healthy and tumor tissues is proliferation-related
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    Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry
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    Alterations of redox and iron metabolism accompany development of HIV latency.
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    Time-resolved genome-scale profiling reveals a causal expression network
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    Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells
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    Controlling the Mitochondrial Protonmotive Force with Light to Impact Cellular Stress Resistance
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    The mitochondrial Rho-GTPase, Miro, is resident at peroxisomes and regulates peroxisomal trafficking and morphology
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    Local rewiring of genome - nuclear lamina interactions by transcription.
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    Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies
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    Cristae undergo continuous cycles of fusion and fission in a MICOS-dependent manner
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    Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cells
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    Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment
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    Mammalian gene expression variability is explained by underlying cell state
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    Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology
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    Huntington phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice
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    Cytoskeletal tension actively sustains the T cell immunological synapse
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  71. Nov 2019
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    TAF-ChIP: An ultra-low input approach for genome wide chromatin immunoprecipitation assay
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    Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis
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    Resolving kinesin stepping: one head at a time
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    Detecting Novel Sequence Signals in Targeting Peptides Using Deep Learning
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    Sufficiency analysis of estrogen responsive enhancers using synthetic activators
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    Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity
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    Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1
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    Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells
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    Combinatorial prediction of gene-marker panels from single-cell transcriptomic data.
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    High affinity interactions and signal transduction between Aβ oligomers and TREM2
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    Pannexin-1 Channels govern the Generation of Necroptotic small Extracellular Vesicles
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    The Israeli Acute Paralysis Virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
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    Long-term expanding human airway organoids for disease modelling.
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    Plasma proteome profiling to detect and avoid sample-related biases in biomarker studies
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    Estrogen receptor alpha controls gene expression via translational offsetting
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    Paralog dependency indirectly affects the robustness of human cells
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    Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions
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    S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate desmosome assembly and cell adhesion.
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    An integrated workflow for cross-linking/mass spectrometry
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    Elucidation of the viral disassembly switch of tobacco mosaic virus
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  92. Sep 2019
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    Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome
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    let-7 controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41
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    Ncl1 mediated metabolic rewiring is critical during metabolic stress
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    Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission
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    XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures
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    Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC
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    The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells
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    Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutants
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  101. www.biorxiv.org www.biorxiv.org
    Molecular characterization of CHAD domains as inorganic polyphosphate binding modules
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    Hierarchical organization of the human cell from a cancer coessentiality network
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    BZLF1 interacts with the chromatin remodeler INO80 promoting escape from latent infections with Epstein-Barr virus
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    The chaperone-client network subordinates cell-cycle entry to growth and stress
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    Maternal Circulating MicroRNAs Control the Placental Response to Alcohol
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    Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association
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    Intra-individual methylomics detects the impact of early-life adversity
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    Human DNA polymerase delta is a pentameric complex with dimeric p12 subunit: Implications in enzyme architecture and PCNA interaction
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    PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts and white matter changes
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    Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements
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    Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humans
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    The small and large ribosomal subunits depend on each other for stability and accumulation
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    Main constraints for RNAi induced by expressed long dsRNA in mouse cells
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    MiR-146a wild-type 3\' sequence identity is dispensable for proper innate immune function in vivo
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    Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
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    A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs
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    Rab1b and ARF5 are novel RNA-binding proteins involved in IRES-driven RNA localization
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    Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1
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    Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4
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    An integrative machine learning approach for prediction of toxicity-related drug safety
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    Phosphorylation of Arp2 is not essential for Arp2/3 complex activity in fission yeast
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    Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
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    Novel organelle anion channels formed by chromogranin B drive normal granule maturation in endocrine cells
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    Cumulative regulatory potential of clustered methyl-arginine protein modifications
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    Loss of Wt1 in the murine spinal cord alters interneuron composition and locomotion
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    CHRAC/ACF Contribute to the Repressive Ground State of Chromatin
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    Role of Cnot6l in maternal mRNA turnover
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    JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell-derived neural progenitors and cortical neurons.
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    The repressive and alleviating nature of FACT shapes the transcriptional landscape in ES cells
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    The histone chaperone FACT modulates nucleosome structure by tethering its components
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    Dynamic m6A methylation facilitates mRNA triaging to stress granules
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    DHX15 regulates CMTR1-dependent gene expression and cell proliferation
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    Co-existing feedback loops generate tissue-specific circadian rhythms
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    Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
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    The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo
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    The TRAPP complex mediates secretion arrest induced by stress granule assembly
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    Endo-lysosomal sorting and degradation of Tau mediates glucocorticoid-driven hippocampalmalfunction
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    Actin filaments regulate microtubule growth at the centrosome.
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    Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network
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    The β3-integrin endothelial adhesome regulates microtubule dependent cell migration
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    Mapping In Vivo O-Glycoproteome Using Site-specific Extraction of O-linked glycopeptides (EXoO)
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    Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing
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    F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes
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    A genetic system for generating single-sex progeny in mice
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    Multiple C2 domains and Transmembrane region Proteins (MCTPs) tether membranes at plasmodesmata
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    Functional systemic CD4 immunity is a differential factor for clinical responses to PD-L1/PD-1 blockade therapy in lung cancer
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    Disentangling bacterial invasiveness from lethality in an experimental host-pathogen system
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    RASSF1A Is Required For The Maintenance Of Nuclear Actin Levels
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    Stalk-mediated communication in the dynein motor domain
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    Euchromatic histone methyltransferases regulate peripheral heterochromatin tethering via histone and non-histone protein methylations
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    Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice
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    PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure
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    LRX- and FER-dependent extracellular sensing coordinates vacuolar size for cytosol homeostasis
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    The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity
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    Absolute quantification of translational regulation and burden using combined sequencing approaches
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    Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages
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    Mechanistic causes of constrained phenotypic variation revealed by synthetic gene regulatory networks
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    The fitness cost and benefit of phase separated protein deposits
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    Defining the RNA Interactome by Total RNA-Associated Protein Purification
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    SWI/SNF chromatin remodeling controls Notch-responsive enhancer accessibility
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    Asymmetric Distribution of Glucose Transporter mRNA Provides Growth Advantage
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    In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex
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    Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex
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    Evidence that the cell cycle is a series of uncoupled, memoryless phases
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    The fungal root endophyte Serendipita indica modifies extracellular nucleotides to subvert plant immunity
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    SSU72 phosphatase is a telomere replication terminator
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    De novo Gene Signature Identification from Single-Cell RNA-Seq with Hierarchical Poisson Factorization
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    Quantification and discovery of sequence determinants of protein per mRNA amount in 29 human tissues
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    A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
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    Structures of the heart specific SERCA2a Ca2+-ATPase
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    Length-independent telomere damage drives cardiomyocyte senescence
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    Widespread inter-individual gene expression variability in Arabidopsis thaliana
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    CRISPR Cas9 searches for a protospacer adjacent motif by one-dimensional diffusion
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    CDK phosphorylation of Xenopus laevis M18BP1 promotes its metaphase centromere localization
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    Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death
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    Bimodal Spindle Orientation Drives Tissue Regularity in a Proliferating Epithelium
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    Avidity-driven polarity establishment via multivalent lipid-GTPase module interactions
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    The key protein of endosomal mRNP transport binds translational landmark sites of cargo mRNAs
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    Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus
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    S phase R-loop formation is restricted by PrimPol-mediated repriming
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    A common molecular logic determines embryonic stem cell self-renewal and reprogramming
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    Functional Compensation Between Hematopoietic Stem Cells In Vivo
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    Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability
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    Synergistic Recruitment of UbcH7~Ub and Phosphorylated Ubl Domain Triggers Parkin Activation
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    Synthesis and degradation of FtsZ determines the first cell division in starved bacteria
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    Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
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    ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
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    Transcriptional control and exploitation of an immune-responsive family of retrotransposons in Arabidopsis
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    Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming
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    Paupar LncRNA Promotes KAP1 Dependent Chromatin Changes And Regulates Subventricular Zone Neurogenesis
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    TRIP6 inhibits the Hippo signaling pathway in response to tension at adherens junctions
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    CTCF, WAPL and PDS5 proteins control the formation of TADs and loops by cohesin
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    Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model
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    Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations
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    Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis
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    Ratiometric Distribution Of OCT4 During Stem Cell Division Controls The Balance Between Self-Renewal And Differentiation
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    Multi-Omics factor analysis disentangles heterogeneity in blood cancer
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    FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
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    Fibroblast state switching orchestrates dermal maturation and wound healing
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