for - interview - Michael Levin - Dennis Noble D 4 min Hodgkin cycle ion channels and global properties of cell voltage work together - multi level approach

Heart organ constrains molecular level functions

Neo Darwinism is not a good model Dna cannot self replicate itself like a crystal as Schroedinger thought, it needs a cell to do it

M ?

D Many viruses have introduced properties into our germ line

Have to take into account epigenetic inheritance

Fluorescent labels to identify molecules in vesicles to identify which molecules are passed down to the germ line

There are millions of potential molecules but the fluorescence technique can only follow 4 or 5 if these

M ? What is your guess of % of genetic Vs epi-genetic contribution to germ line?

D Difficult to say Epigenetic must contribute large fraction to cell differentiation Digital information - from 3 billion DNA base pairs Analog information - exceeds DNA base pairs

Paddington - introduced the term epigenetic in the 50s

Exercising tells cells to grow more proteins It's ubiquitous

Life is the creator of life Life can alter DNA all the time - ie immune system is doing it all the time Life can alter what it's physiologically doing Life does have purpose /intention Many standard texts rule out of court certain ideas is.Lamark is disallowed Lamark and Darwin did not disagree

John Maynard Smith, an engineer by trade wrote The Theory of Evolution to teach himself evolution

He never accepted Wiseman Barrier Evolution textbooks need to be rewritten

M? What off the one thing that needs to change?

D Re write texts books

for - adjacency - Buddhist teachings - Four Noble Truths - life and death - mortality salience - terror management technique

adjacency - between - Buddhist teachings - Four Noble Truths - life and death - mortality salience - terror management technique - adjacency relationship - The Four Noble Truths are: - the recognition of inherent suffering - the cause of suffering - understanding the cause of suffering - the cessation of suffering - and are really - a way to deal with mortality salience and therefore - a terror management technique

for - critique of - Gene Centricity - Denis Noble

from - youtube -Evolution 2 Podcast Interview - Denis Noble - Book - Understanding Living Systems - https://hyp.is/-EuWvBYHEe-t9xtn9h1dhA/docdrop.org/video/oHZI1zZ_BhY/

for - health advice - aging well - Denis Noble

health advice - aging well - ll if you want to age well do something! - It can be - dancing - music - swimming - whatever but do something - That's the first bit of advice to those who want to make sure that they stay on top

for - critique - of Watson & Cricks DNA - agency of organisms

critique - of Watson & Cricks DNA - agency of organisms - Watson & Cricks advocated the now disproven idea that causality is only one direction - from genes to - proteins to - functionality of living organisms - when in fact, it goes the other way, giving the high level living organism agency

for - question - impact of climate change on male and female population distribution of the biosphere

question - impact of climate change on male and female population distribution of the biosphere - How will climate change affect the proportion of males and females of the many species that are and will be impacted by dramatic temperature changes?

for - individual / collective gestalt - gene centrism - paradigm shift - adjacency - mistake of 20th century biology - reductionism - separating organism from environment - individual / collective gestalt, individual / environment gestalt - quote - mistake of 20th century biology - Ray Noble - key insight - mistake of 20th century biology- Ray Noble

quote - mistake of 20th century biology - Ray Noble - (see below)

• I think one of the other mistakes that have been made in biology of the 20th century
  • was to treat organisms as if they existed within an environment that was sort of like some nebulous box as it were
  • and you could study the organism by taking it out
  • and you study it in isolation
• It's the beginning of reductionism in a sense because
  • you taken it away from the environment but the organism has an intimate relationship with the environment
• It's feeding both
  • to the environment and
  • from the environment
• What is that environment?
  • That environment in large part is
    • other organisms of the same species but
    • other organisms of different species
• and it's in a continuous bubble of change
• It's like a cauldron of change
• So the big question for life is
  • how do you maintain yourself in this cauldron of change?
• You cannot do it by standing still
• You have to respond to it
  • so it's not surprising therefore that you find that you know organisms have mechanisms for responding to those changes

adjacency - mistake of 20th century biology - between - reductionism - separating organism from environment - individual / collective gestalt, - individual / environment gestalt - adjacency relationship - The mistake that 20th century biology has made is in - ascribing too much power to the gene, and - minimizing the role of epigenetics - Focusing the majority of attention and resources on the genes of the organism, and - defocusing attention on the organisms (epigenetic) interactions with the environment, including both - biotic elements and - abiotic elements - It's not the case that the genes are the major determinant factor and the epigenetics play a minor role - It IS the case that epigenetics play an equally important role in transmitting and assimilating features into the genome - The individual organism is intertwingled with its environment and with other living organisms - The individual / collective gestalt and the individual / environment gestalt is the appropriate unit of study

for - progress trap - genetic engineering - Denis Noble

for - Denis Noble - Ready Noble - evolutionary biology - critique of Richard Dawkins Selfish Gene theory - critique of gene centrism - book - Understanding Living Systems - human agency

summary - In this informative interview, brothers Denis and Ray Noble discuss their new book - Understanding Living Systems, and - dispel the 70 year old narrative of Gene centrism and the selfish gene as determining the high level behaviour of living organisms

for - quote - genes don't control Richard Dawkins - Ray Noble

for - quote - the age of reason became unreasonable - Ray Noble

quote - the age of reason became unreasonable - Ray Noble - (see below)

• The Age of Reason became unreasonable
  • in the sense of treating us as machines
• Reason requires openness ,
  • it doesn't require a closed view of life and of humanity

for - quote - human agency - Ray Noble

quote - (see below)

• It had to give us something which all the other organisms didn't have which was
  • a cell that was different
  • a mind that was different
• that gave us agency
  • but denied it to other organisms
  • and that unfortunately I think persisted

for - purpose in nature - exorcism of - Ray Noble - quote - gene centered view - organisms as machines - exorcism - Ray Noble - gene centered view

for - quote - progress trap - speed of cultural evolution - Ray Noble

for - recombination of proteins in higher level proteins - from - youtube - Evolution 2 podcast interview - book - Understanding Living Systems - Denis Noble - Ray Noble

from - youtube - Evolution 2 podcast interview - book - Understanding Living Systems - Denis Noble - Ray Noble - https://hyp.is/OttWABYFEe--gLNFyeNyTw/docdrop.org/video/oHZI1zZ_BhY/

for - Oded Rechavi - neurobiology - gene centrism - critique - from - youtube podcast interview - book - Understanding Living Systems - Ray Noble - Denis Noble

summary - Rechavi performed experiments with C Elegan and demonstrated that it possesses a type of neuron that - produces RNA that in response to elevated temperature change is transmitted to reproductive cells so that the offsprings encode it in the genome, and it is better adapted to deal with elevated temperatures

question - How many species do this? Is it generally found throughout nature?

from - outube podcast interview - book - Understanding Living Systems - Ray Noble - Denis Noble - https://hyp.is/OUlGVBXrEe-iaBeZhH_4DQ/docdrop.org/video/oHZI1zZ_BhY/

for - quote - reductionism has failed - Denis Noble

for - follow up - paper - Could physiology rescue genomics?

to - Could physiology rescue genomics? - https://hyp.is/bslQ-BVVEe-hgF-rrNmjrA/academic.oup.com/biolinnean/article/139/4/357/6604006

for - adjacency - progress trap - Crispr - gene therapy - Denis Noble - human genome project

adjacency - between - human genome project - gene therapy - Crispr - progress trap - adjacency relationship - The idea that we can find specific causal relationships between genes and disease and use gene therapy to cure disease, - an envisioned goal of the human genome project - can be very dangerous because - usually one gene collaborates with many other genes to bring about an effect - If we don't know all the relationships, we can bring about a progress trap

for - comparison - human vs AI robot - Denis Noble

for - quote - Darwin would never have been a Neo-Darwinian - Denis Noble

for - metaphor - genes - musical scores - Denis Noble

for - quote - being wrong - Denis Noble

quote - Being wrong - Denis Noble - If we didn't have people who were wrong - we wouldn't be where we are

for - physiology rescues evolutionary biology - Denis Noble

from - youtube - IAI interview - Why Dawkins is Wrong - Denis Noble

for - paper - Physiology restores purpose to evolutionary biology - Denis Noble - Raymond Noble - year - 2023

from - youtube - IAI interview - Why Dawkins is wrong - Denis Noble - https://hyp.is/eqKOYhVVEe-XVKuwMtOTTg/docdrop.org/video/dCLRKP9NW8I/

for - molecular biology - paradigm shift - living system - 4 common misunderstandings - book - Understanding Living Systems - 4 common misunderstandings

4 common misunderstandings of living systems - 1. The central dogma of molecular biology - one way causation - Genes (DNA) to - proteins to - organism - 2. The Weismann Barrier - 3. DNA as self-replicator - 4. Separation of Replicator (DNA) and Vehicle (Living cell) are completely separate

for - quote - Denis Noble - quote - baby not born selfish

for - book - Biology Beyond the Genome - author - scientist - biologist - Denis Noble - book - Understanding Living Systems

for - Keith Baverstock - paper - The Gene and Appraisal

from - youtube - Biology Beyond the Gene - Denis Noble - https://hyp.is/UrvwdhVDEe-QWrPAx9y1aw/docdrop.org/video/bzXFSufDDn8/

In den USA besteht seit langem eine Netzwerk, in dem PR-Firmen mit Unternehmen der Fossilindustrie zusammenarbeiten, Dabei werden u.a. durch gefakete Kampagnen und die Gründung von Umweltgruppen die eigentlichen Stakeholder der Desinformation versteckt. In einem Hearing eines Unterausschusses des Repräsentantenhauses wurden die Praktiken von PR-Firmen aufgedeckt. https://www.desmog.com/2022/09/14/house-committee-pr-climate-disinformation/

https://MarkNoble.com

https://tedgioia.substack.com/p/what-can-we-learn-from-barnes-and

...and if the West sides with Taiwan if China decides to invade it, we will see a repeat of Putin's strategy of limiting export of vital noble gases. Team human doesn't work well when we cannot collaborate

Russia supplies 30% of the global chip industry with neon, argon and helium, necessary for chip manufacturing.

The idea of the "noble savage" can be traced back to early French encounters with indigenous Americans who felt that because the men occupied themselves with hunting and war that they were more like the French noblemen who employed themselves in similar pursuits.

I find it very interesting that they refer to Mansa Musa and Musse Melly. I wouldn’t have understood they were referring to the same person if it wasn’t for the fact they stated about his riches and wealth. In addition, it confirms the fact that he was very wealthy which is stated in many texts. He was wealthy for extracting of riches, but he also was influential leader in Africa.

Bear in mind that this "ownership" is common practice with Amazon, Apple, Google, Kobo, Barnes and Noble, and other ones as well.

It's not this way with non-DRM books, that you can download, and reuse as with physical books.