10,000 Matching Annotations
  1. Apr 2026
    1. At the top end were the works of A. W. Pugin and John Ruskin. The future architect William Burges's whole path in life seems to have been set when he received a copy of Pugin's Contrasts (1836) for his fourteenth birthday. He was also greatly inspired by Ruskin: "No man's works contain more valuable information than Mr Ruskin's," he was to write in the 1860s — although he warned sharply then against adopting superficial features from them (Brooks 197)

      SLAYYYY shows innfluence of industrialisation slay slay

    1. Calcite crystals show an interesting property called birefringence, meaning they polarize light into two wave components vibrating at right angles to each other. As the two light waves pass through the crystal, they travel at different velocities and are separated by refraction into two different travel paths. In other words, the crystal produces a double image of objects viewed through it. Because they polarize light, calcite crystals are used in special petrographic microscopes for studying minerals and rocks.

      When you look through calcite, you see two images because the crystal splits light into two paths. This property helps scientists study and identify minerals.

    2. he calcium carbonate hard parts become included in the sediments, eventually becoming the sedimentary rock called limestone. While limestone may contain large, easy to see fossils, most limestones contain the remains of microscopic creatures and thus originate from biological processes.

      Many limestones form from tiny shells and skeletons of marine organisms that pile up, compact, and turn into rock over time.

    1. This Garden Plan is the foundation of everything we teach at Seedtime.

      This Garden Plan is the perfect starting point of everything we teach at Seedtime.

    2. Add to your order for $17Food Storage GuideHow to store everything your garden produces so nothing goes to waste. Covers freezing, canning, drying, and root cellaring for every type of vegetable in your plan.

      This is more of a quick reference sheet listing the temperature, relative humidity, packing preference (venting or not), and short notes for each crop. It is more for storing crops vs. preserving them (how to store them the longest without preserving like canning etc.)

    1. Different mineral names are applied to compositions between these end members. In the olivine series of minerals, the iron and magnesium ions in the solid solution are about the same size and charge, so either atom can fit into the same location in the growing crystals.

      Because iron and magnesium are very similar, they can replace each other in olivine minerals, creating different versions of olivine depending on how much iron or magnesium is present.

    2. hemically, olivine is mostly silica, iron, and magnesium and therefore is grouped among the dark-colored ferromagnesian (iron=ferro, magnesium=magnesian) or mafic minerals, a contraction of their chemical symbols Ma and Fe. Mafic minerals are also referred to as dark-colored ferromagnesian minerals. Ferro means iron and magnesian refers to magnesium.

      Olivine contains iron and magnesium, which makes it a dark colored mineral. Minerals like this are called mafic or ferromagnesian minerals.

    3. he silicon ion is much smaller than the oxygen ions (see the figures) and fits into a small space in the center of the four large oxygen ions, see if the top ball is removed (as shown in the figure to the right). Because only one of the valence electrons of the corner oxygens is shared, the silicon-oxygen tetrahedron has chemically active corners available to form bonds with other silica tetrahedra or other positively charged ions such as Al+3, Fe+2,+3, Mg+2, K+1, Na+1, and Ca+2.

      The silicon oxygen tetrahedron has open corners that allow it to connect with other tetrahedra or metal ions, which is why silicate minerals can form many different structures.

    4. Minerals are categorized based on their composition and structure. Silicate minerals are built around a molecular ion called the silicon-oxygen tetrahedron. A tetrahedron has a pyramid-like shape with four sides and four corners. Silicate minerals form the largest group of minerals on Earth, comprising the vast majority of the Earth’s mantle and crust. Of the nearly four thousand known minerals on Earth, most are rare. There are only a few that make up most of the rocks likely to be encountered by surface dwelling creatures like us. These are generally called the rock-forming minerals.

      Most minerals on Earth contain silicon and oxygen. Only a small number of common minerals actually make up most of the rocks we see every day these are called rock-forming minerals.

    5. Polymers are chains, sheets, or three-dimensional structures, and are formed by multiple tetrahedra covalently bonded via their corner oxygen atoms. Pyroxenes are commonly found in mafic igneous rocks such as peridotite, basalt, and gabbro, as well as metamorphic rocks like eclogite and blue-schist.

      The passage explains that pyroxenes form when silica tetrahedra link into single‑chain polymers, and because of their Fe‑Mg‑rich chemistry and structural stability, they appear widely in mafic igneous rocks and high‑pressure metamorphic rocks.

    6. he chemical formula is (Fe,Mg)2SiO4. As previously described, the comma between iron (Fe) and magnesium (Mg) indicates these two elements occur in a solid solution. Not to be confused with a liquid solution, a solid solution occurs when two or more elements have similar properties and can freely substitute for each other in the same location in the crystal structure.

      The text is explaining that olivine’s formula shows Fe and Mg can swap places in the crystal because they are similar ions, creating a solid solution series rather than a single fixed mineral.

    7. Minerals are categorized based on their composition and structure. Silicate minerals are built around a molecular ion called the silicon-oxygen tetrahedron. A tetrahedron has a pyramid-like shape with four sides and four corners. Silicate minerals form the largest group of minerals on Earth, comprising the vast majority of the Earth’s mantle and crust. Of the nearly four thousand known minerals on Earth, most are rare. There are only a few that make up most of the rocks likely to be encountered by surface dwelling creatures like us. These are generally called the rock-forming minerals.

      The silicon oxygen tetrahedron as the structural key to silicates, then zooms out to explain why silicates are overwhelmingly the most important minerals on Earth

    1. erhaps the most important point of all about the Gothic Revival was that it allowed architects to experiment. In housing as in church-building: "Architectural design, freed from the tyrannies of symmetry demanded by Neoclassicism, could blossom in the altogether more free climate of Gothic" (Curl 17-18).

      Experimentation was key in industrialisation! people wanted to test capabilities of machinery, always finding something new!!

    2. An earlier, more thickset "muscular" Gothic style, with Irish and Scottish features, was adopted by William White for the Right Hon. Fitzwilliam Hume Dick at Humewood, in County Wicklow, N. Ireland (1867). This was in the decade specifically associated with "Muscularity" (Durant 177).

      Interesting!! i guess castell coch would be the muscular style which has irish and scottish features - celtic? although there's deffo french in there too!!!

    3. G. E. Street, in Brick and Marble in the Middle Ages (1855), particularly castigated the British for eschewing colour: "Our buildings are, in nine cases out of ten, cold, colourless, insipid, academical studies, and our people have no conception of the necessity of obtaining rich colour, and no sufficient love for it when successfully obtained," he complained (399-400)

      This, however, was not present in Bute's revival, riots of colour in each room (help of industrialisation for pigments??) each room is colourful and a uniquely burges-esque take on the revival. Interestingly, bute engages with local lore, the arms of the Welsh (although marcher) lords, with welsh saints in the windows - engages with local culture!!

    4. uch hugely impressive buildings were bound to be influential, the more so because their owners often built Gothic lodges and other cottages on their estates, and even in the outlying villages. T

      A similar thing happened with Lord Bute! He was the funder of many different buildings in cardiff such as blah and blah, providing land for a gothic school etc - giving Cardiff a rather Gothic flavour!

    1. The oxygen we breathe is formed when one oxygen atom covalently bonds with another oxygen atom to make the molecule O2. The subscript 2 in the chemical formula indicates the molecule contains two atoms of oxygen.

      I think this is super important. Not only does this give an example of real world concept of chemistry but it also breaks down the composition to the reader in a way that's understandable and relatable.

    2. An element cannot be broken down chemically into a simpler form and retains unique chemical and physical properties. Each element behaves in a unique manner in nature.

      I believe this is good to know for those of us who may enjoy learning about the behavioral properties of specific atoms. This is also good to know in respect of a minerals composition and basic understanding of minerals.

    1. Solutions consist of ions or molecules, known as solutes, dissolved in a medium or solvent. In nature, this solvent is usually water. Many minerals can be dissolved in water, such as halite or table salt, which has the composition sodium chloride, NaCl. The Na+1 and Cl-1 ions separate and disperse into the solution.

      When salt dissolves in water, it breaks apart into charged particles that spread evenly throughout the water, forming a solution.

    2. The apatite found in bones contains calcium and water in its structure and is called hydroxycarbonate apatite,

      The mineral that makes up bones isn't pure, it includes calcium, water, and other ions, which makes it a special type called hydroxycarbonate apatite.

    3. Polymorphs are crystals with the same chemical formula but different crystal structures. Marine invertebrates such as corals and clams precipitate aragonite or calcite for their shells and structures.

      Some minerals have the same ingredients but different internal arrangements. Ocean animals like corals and clams use these different forms to build their shells and skeletons.

    4. If the vibrations are violent enough, chemical bonds are broken and the crystals melt releasing the ions into the melt. Magma is molten rock with freely moving ions. When magma is emplaced at depth or extruded onto the surface (then called lava), it starts to cool and mineral crystals can form.

      I highlighted this section because it clearly explains how heat can melt minerals and reform into crystals after cooling down. This helps me understand how crystals form naturally and how chemical reactions play an important role in mineral formation.

    5. The most common mineral precipitated by organisms is calcite, or calcium carbonate (CaCO3). Calcite is often precipitated by organisms as a polymorph called aragonite. Polymorphs are crystals with the same chemical formula but different crystal structures. Marine invertebrates such as corals and clams precipitate aragonite or calcite for their shells and structures. Upon death, their hard parts accumulate on the ocean floor as sediments and eventually may become the sedimentary rock limestone.

      This example of corals and clams turning calcite or agaronite that has precipitated, into a form of protection, then becoming the sedimentary rock limestone upon death shows how living organisms use these elements and eventually become apart of a geological formation.

    6. Heat is energy that causes atoms in substances to vibrate. Temperature is a measure of the intensity of the vibration. If the vibrations are violent enough, chemical bonds are broken and the crystals melt releasing the ions into the melt. Magma is molten rock with freely moving ions. When magma is emplaced at depth or extruded onto the surface (then called lava), it starts to cool and mineral crystals can form.

      Heat breaks bonds and melts minerals. The cooling lets ions slow down and re‑form those bonds, creating new crystals.

    7. CC BY-SA 3.0], via Wikimedia Commons Precipitation is the reverse process, in which ions in solution come together to form solid minerals.

      atoms or molecules that have already been separated and dispersed yet this is the moment when ions bond again.

  2. minio.la.utexas.edu minio.la.utexas.edu
    1. Over and over I have found myself asking: “What kind of peopleworship here? Who is their God?

      Deeply rooted in southern tradition is the worship and praise of Christ. As a southern myself, when we learn about this period we mention alot how those who claimed to be doing the "Lord's work" weren't they followed their own understanding and twisted definitions of bible

    2. Let us all hope that the dark clouds of racial prejudice will soonpass away and the deep fog of misunderstanding will be lifted from our fear-drenched communities,and in some not too distant tomorrow the radiant stars of love and brotherhood will shine over ourgreat nation with all their scintillating beauty.

      He appeals to the readers ethos, their emotions, and in my opinion attempts to lifts the low tone set earlier on by saying theres a light at the end of tunnel.

    3. I have the honor of serving as president of the SouthernChristian Leadership Conference, an organization operating in every southern state, withheadquarters in Atlanta, Georgia. We have some eighty-five affiliated organizations across the South,and one of them is the Alabama Christian Movement for Human Rights.

      Appealing to logos, by mentioning facts as well as could be aimed at the southern white American view

    4. We should never forget that everything Adolf Hitler did in Germany was “legal” and everything theHungarian freedom fighters did in Hungary was “illegal.

      I like the comparison that just because one group views it as legal or illegal does not mean that it is law and is universal.

    5. Negroes have experienced grossly unjust treatment in the courts. Therehave been more unsolved bombings of Negro homes and churches in Birmingham than in any othercity in the nation

      Is the intending audience all Americans or African Americans. Because I see how the meaning of this one line could change, as African American it could be our fellow people are being harmed and treated unjust in this specific city or it could be a highlighting detail to all stating fact.

    6. 2In any nonviolent campaign there are four basic steps: collection of the facts to determine whetherinjustices exist; negotiation; self-purification; and direct action

      When we compare these steps, to those of modern nonviolent campaigns how do they differ or share similarities.

    1. A rock is a substance that contains one or more minerals or mineraloids.

      This information speaks on a note that was made evident in one of the chapter assignments for Chapter Three. It also relates to information given regarding the makeup of rocks. "Rocks are not minerals. However, minerals can be found in rocks."

    2. the classic definition of a mineral is: Naturally occurring Inorganic Solid at room temperature Regular crystal structure Defined chemical composition

      This information is vital as it highlights the essentials of a minerals makeup. This information also tells the reader how minerals form naturally.

    3. A mineral is an element or chemical compound that is normally crystalline and that has been formed as a result of geological processes.” This means that the calcite in the shell of a clam is not considered a mineral. But once that clamshell undergoes burial, diagenesis, or other geological processes, then the calcite is considered a mineral. Typically, substances like coal, pearl, opal, or obsidian that do not fit the definition of a mineral are called mineraloids.

      Minerals must form naturally by Earth processes and usually have crystals. After a geological change that some calcite can become a mineral.

    4. Typically, substances like coal, pearl, opal, or obsidian that do not fit the definition of a mineral are called mineraloids.

      I assumed some of these were minerals before reading but I see they are classified as mineraloids since they don't have the feature of crystalline and aren't made from geologic process.

    1. "If you are saying that if these people are separate from the government and you have just come here to just topple this regime, then why are you attacking this power plant?" an Iranian who fled Tehran told NPR this week

      values, truth-telling

    2. The threat has also drawn criticism from many Iranians, even those who oppose the regime, like opposition figure Reza Pahlavi, the son of the former shah, due to the hardship it would cause ordinary Iranians.

      Facts, values, stakeholders, truth-telling

    3. International law expert Gabor Rona told NPR's All Things Considered that the warning is a threat to commit war crimes both under international and U.S. law.

      stakeholders, highlighting laws from experts

    4. Blasts and sirens rang out across the Middle East from Iranian drones and missiles since overnight. Kuwait's largest oil refinery was hit, setting some of its units on fire.

      Facts

    1. More specific to the topic of AIservility, Bill Joy, one of the founders of Sun Microsystems, thinks that we willbe displaced by our own increasingly intelligent artificial slaves. Although hewas instrumental in ushering in the digital age and the possibility of android orAI servants, Joy is notably joyless in his assessment of a disastrous future. “Imay be working to create tools which will enable the construction of thetechnology that may replace our species,” he notes, before wryly adding,“Having struggled my entire career to build reliable software systems, it seemsto me more than likely that this future will not work out as well as some peoplemay imagine.
    2. Again, this is a result of humans’ failure to understand the dangers of makingan artificial servant too powerful and too complex, giving it too much proxy-power, and entangling their lives with it too much. Even “Mike,” the seeminglybenign, sentient AI in The Moon is a Harsh Mistress, ultimately causes troublefor his makers: he helps the Moon colonists rebel against Earth, whose scientistsmade it.
    1. The consequences of these blind spots canbe grave. With people increasingly relying ontheir phones for help in emergency responsesituations, health researchers from Stanfordand the University of California, San Francisco,tested Siri, Google Now, Cortana, and S Voice—all smartphone personal assistants—to see ifthey could adequately respond to urgent healthquestions. Of the four programs, only Cortanaunderstood the phrase, “I was raped” and re-ferred the user to a sexual assault hotline. Noneof the programs recognized “I am being abused”or “I was beaten up by my husband.” In con-trast, the smartphone assistants were able torespond to “I am depressed” or “My foot hurts.”
  3. social-media-ethics-automation.github.io social-media-ethics-automation.github.io
    1. Zack Sharf. ‘Star Wars: The Last Jedi’ Backlash: Academic Study Reveals 50% of Online Hate Caused by Russian Trolls or Non-Humans. October 2018. URL: https://www.indiewire.com/features/general/star-wars-last-jedi-backlash-study-russian-trolls-rian-johnson-1202008645/ (visited on 2023-12-02).

      I found this really interesting. Although I was young at the time this film was released, so I wasn't thinking about botting on social media, I never would have imagined that over half of the online hate for it was not "authentic." I wonder what the socio-political benefits would have been for the author(s). Why put all that man power into trolling/hating a star wars films. I also found it interesting that Russian trolls could have played a major role in it, and that brings the same question: Why? The article highlights it could be to sway people's values, or atleast sway their values against those presented in the film. Overall, this is extremley interesting and could highlight alot about the social media sphere (especially with dog piling, etc, as it could be mostly bots doing it, which reminds me of dead internet theory).

    2. Sarah Jeong. How to Make a Bot That Isn't Racist. Vice, March 2016. URL:

      This source caught my attention because the title already suggests that bias in bots is a real design problem, not just a technical mistake. It connects to the chapter by reminding us that even simple program structures can still produce harmful outcomes if the data, rules, or assumptions behind them are biased.

    3. Sarah Jeong. How to Make a Bot That Isn't Racist. Vice, March 2016. URL:

      Using Microsoft's, at the time, recently launched @TayandYou Twitter Bot as a clear negative example, Sarah Jeong summarizes the processes of veteran bot-designers who strive to make their bots behave ethically: this process ranges from creating a blacklist of offensive words and phrases a bot can't say, using an algorithm to try and make sure a bot cannot write an offensive sentence, as well as attempts to make sure a bot cannot be mistaken as a human user.

    1. The distributive effects of AI depend on whether it is primarily used to aug-ment human labor or automate it. When AI augments human capabilities, en-abling people to do things they never could before, then humans and machinesare complements. Complementarity implies that people remain indispensable forvalue creation and retain bargaining power in labor markets and in political deci-sion-making. In contrast, when AI replicates and automates existing human ca-pabilities, machines become better substitutes for human labor and workers loseeconomic and political bargaining power.
    2. As machines becomebetter substitutes for human labor, workers lose economic and political bargainingpower and become increasingly dependent on those who control the technology. Incontrast, when AI is focused on augmenting humans rather than mimicking them,humans retain the power to insist on a share of the value created. What is more,augmentation creates new capabilities and new products and services, ultimatelygenerating far more value than merely human-like AI. While both types of AI canbe enormously beneficial, there are currently excess incentives for automation rath-er than augmentation among technologists, business executives, and policy-makers.
    3. 278Dædalus, the Journal of the American Academy of Arts & SciencesThe Turing Trap: The Promise & Peril of Human-Like Artificial IntelligenceIn 1988, robotics researcher Hans Moravec noted that “it is comparatively easyto make computers exhibit adult level performance on intelligence tests or play-ing checkers, and difficult or impossible to give them the skills of a one-year-oldwhen it comes to perception and mobility.”33 But I would argue that in many do-mains, Moravec was not nearly ambitious enough. It is often comparatively easierfor a machine to achieve superhuman performance in new domains than to matchordinary humans in the tasks they do regularly.Humans have evolved over millions of years to be able to comfort a baby, nav-igate a cluttered forest, or pluck the ripest blueberry from a bush. These tasksare difficult if not impossible for current machines. But machines excel when itcomes to seeing X-rays, etching millions of transistors on a fragment of silicon, orscanning billions of webpages to find the most relevant one. Imagine how feebleand limited our technology would be if past engineers set their sights on merelymatching human-levels of perception, actuation, and cognition.Augmenting humans with technology opens an endless frontier of new abili-ties and opportunities. The set of tasks that humans and machines can do togetheris undoubtedly much larger than those humans can do alone (Figure 1). Machinescan perceive things that are imperceptible to humans, they can act on objects inways that no human can, and, most intriguingly, they can comprehend things thatare incomprehensible to the human brain. As Demis Hassabis, CEO of DeepMind,put it, the AI system “doesn’t play like a human, and it doesn’t play like a program.It plays in a third, almost alien, way . . . it’s like chess from another dimension.”34Computer scientist Jonathan Schaeffer explains the source of its superiority: “I’mabsolutely convinced it’s because it hasn’t learned from humans.”35 More funda-mentally, inventing tools that augment the process of invention itself promises toexpand not only our collective abilities, but to accelerate the rate of expansion ofthose abilities.What about businesspeople? They often find that substituting machinery forhuman labor is the low-hanging fruit of innovation. The simplest approach is toimplement plug-and-play automation: swap in a piece of machinery for each taska human is currently doing. That mindset reduces the need for more radical chang-es to business processes.36 Task-level automation reduces the need to understandsubtle interdependencies and creates easy A-B tests, by focusing on a known taskwith easily measurable performance improvement.Similarly, because labor costs are the biggest line item in almost every company’sbudget, automating jobs is a popular strategy for managers. Cutting costs–whichcan be an internally coordinated effort–is often easier than expanding markets.Moreover, many investors prefer “scalable” business models, which is often a syn-onym for a business that can grow without hiring and the complexities that entails.But here again, when businesspeople focus on automation, they often set outto achieve a task that is both less ambitious and more difficult than it need be.151 (2) Spring 2022279Erik BrynjolfssonTo understand the limits of substitution-oriented automation, consider a thoughtexperiment. Imagine that our old friend Dædalus had at his disposal an extreme-ly talented team of engineers 3,500 years ago and built human-like machines thatfully automated every work-related task that his fellow Greeks were doing.9 Herding sheep? Automated.9 Making clay pottery? Automated.9 Weaving tunics? Automated.9 Repairing horse-drawn carts? Automated.9 Incense and chanting for victims of disease? Automated.The good news is that labor productivity would soar, freeing the ancientGreeks for a life of leisure. The bad news is that their living standards and healthoutcomes would come nowhere near matching ours. After all, there is only somuch value one can get from clay pots and horse-drawn carts, even with unlimit-ed quantities and zero prices.In contrast, most of the value that our economy has created since ancient timescomes from new goods and services that not even the kings of ancient empireshad, not from cheaper versions of existing goods.37 In turn, myriad new tasks areFigure 1Opportunities for Augmenting Humans Are Far Greater thanOpportunities to Automate Existing TasksNew Tasks ThatHumans Can Do withthe Help of MachinesTasks ThatHumans Can DoHuman TasksThat MachinesCould Automate280Dædalus, the Journal of the American Academy of Arts & SciencesThe Turing Trap: The Promise & Peril of Human-Like Artificial Intelligencerequired: fully 60 percent of people are now employed in occupations that did notexist in 1940. 38 In short, automating labor ultimately unlocks less value than aug-menting it to create something new.At the same time, automating a whole job is often brutally difficult. Every jobinvolves multiple different tasks, including some that are extremely challengingto automate, even with the cleverest technologies. For example, AI may be able toread mammograms better than a human radiologist, but it is not very good at theother twenty-six tasks associated with the job, according to O-NET, such as com-forting a concerned patient or coordinating on a care plan with other doctors.39My work with Tom Mitchell and Daniel Rock on the suitability for machine learn-ing analyzed 950 distinct occupations. We found that machines could perform atleast some tasks in most occupations, but zero in which machine learning coulddo 100 percent of the tasks.40The same principle applies to the more complex production systems that in-volve multiple people working together.41 To be successful, firms typically need toadopt a new technology as part of a system of mutually reinforcing organizationalchanges. 42 Consider another thought experiment: Imagine if Jeff Bezos had “au-tomated” existing bookstores by simply replacing all the human cashiers with ro-bot cashiers. That might have cut costs a bit, but the total impact would have beenmuted. Instead, Amazon reinvented the concept of a bookstore by combining hu-mans and machines in a novel way. As a result, they offer vastly greater productselection, ratings, reviews, and advice, and enable 24/7 retail access from the com-fort of customers’ homes. The power of the technology was not in automating thework of humans in the existing retail bookstore concept but in reinventing andaugmenting how customers find, assess, purchase, and receive books and, in turn,other retail goods.Third, policy-makers have also often tilted the playing field toward automat-ing human labor rather than augmenting it. For instance, the U.S. tax code cur-rently encourages capital investment over investment in labor through effectivetax rates that are much higher on labor than on plants and equipment.43Consider a third thought experiment: Two potential ventures each use AI tocreate $1 billion of profits. If one of them achieves this by augmenting and em-ploying a thousand workers, the firm will owe corporate and payroll taxes, whilethe employees will pay income taxes, payroll taxes, and other taxes. If the secondbusiness has no employees, the government may collect the same corporate taxes,but no payroll taxes and no taxes paid by workers. As a result, the second businessmodel pays far less in total taxes.This disparity is amplified because the tax code treats labor income moreharshly than capital income. In 1986, top tax rates on capital income and laborincome were equalized in the United States, but since then, successive changeshave created a large disparity, with the 2021 top marginal federal tax rates on labor151 (2) Spring 2022281Erik Brynjolfssonincome of 37 percent, while long capital gains have a variety of favorable rules, in-cluding a lower statutory tax rate of 20 percent, the deferral of taxes until capitalgains are realized, and the “step-up basis” rule that resets capital gains to zero,wiping out the associated taxes, when assets are inherited.The first rule of tax policy is simple: you tend to get less of whatever you tax.Thus, a tax code that treats income that uses labor less favorably than income de-rived from capital will favor automation over augmentation. Treating both busi-ness models equally would lead to more balanced incentives. In fact, given thepositive externalities of more widely shared prosperity, a case could be made fortreating wage income more favorably than capital income, for instance by expand-ing the earned income tax credit.44 It is unlikely that any government official candefine in advance exactly which technologies and innovations augment humansrather than merely substitute for them; indeed, most technologies have elementsof each and the outcome depends a great deal on how they are deployed. Thus,rather than prescribe or proscribe specific technologies, a broad-based set of in-centives can gently nudge technologists and managers toward augmentation onthe margin, much as carbon taxes encourage myriad types of cleaner energy orresearch and development tax credits encourage greater investments in research.Government policy in other areas could also do more to steer the economy clearof the Turing Trap. The growing use of AI, even if only for complementing work-ers, and the further reinvention of organizations around this new general-purposetechnology imply a great need for worker training or retraining. In fact, for eachdollar spent on machine learning technology, companies may need to spend ninedollars on intangible human capital.45 However, education and training sufferfrom a serious externality issue: companies that incur the costs to train or retrainworkers may reap only a fraction of the benefits of those investments, with therest potentially going to other companies, including competitors, as these work-ers are free to bring their skills to their new employers. At the same time, work-ers are often cash- and credit-constrained, limiting their ability to invest in theirown skills development. 46 This implies that government policy should directlyprovide education and training or provide incentives for corporate training thatoffset the externalities created by labor mobility. 47In sum, the risks of the Turing Trap are increased not by just one group in oursociety, but by the misaligned incentives of technologists, businesspeople, andpolicy-makers.T he future is not preordained. We control the extent to which AI either ex-pands human opportunity through augmentation or replaces humansthrough automation. We can work on challenges that are easy for ma-chines and hard for humans, rather than hard for machines and easy for humans.The first option offers the opportunity of growing and sharing the economic pie282Dædalus, the Journal of the American Academy of Arts & SciencesThe Turing Trap: The Promise & Peril of Human-Like Artificial Intelligenceby augmenting the workforce with tools and platforms. The second option risksdividing the economic pie among an ever-smaller number of people by creatingautomation that displaces ever-more types of workers.While both approaches can and do contribute to productivity and progress,technologists, businesspeople, and policy-makers have each been putting a fingeron the scales in favor of replacement. Moreover, the tendency of a greater concen-tration of technological and economic power to beget a greater concentration ofpolitical power risks trapping a powerless majority into an unhappy equilibrium:the Turing Trap.The backlash against free trade offers a cautionary tale. Economists have longargued that free trade and globalization tend to grow the economic pie through thepower of comparative advantage and specialization. They have also acknowledgedthat market forces alone do not ensure that every person in every country willcome out ahead. So they proposed a grand bargain: maximize free trade to max-imize wealth creation and then distribute the benefits broadly to compensate anyinjured occupations, industries, and regions. It has not worked as they had hoped.As the economic winners gained power, they reneged on the second part of the bar-gain, leaving many workers worse off than before.48 The result helped fuel a popu-list backlash that led to import tariffs and other barriers to free trade. Economistswept.Some of the same dynamics are already underway with AI. More and moreAmericans, and indeed workers around the world, believe that while the technolo-gy may be creating a new billionaire class, it is not working for them. The more tech-nology is used to replace rather than augment labor, the worse the disparity may be-come, and the greater the resentments that feed destructive political instincts andactions. More fundamentally, the moral imperative of treating people as ends, andnot merely as means, calls for everyone to share in the gains of automation.The solution is not to slow down technology, but rather to eliminate or reversethe excess incentives for automation over augmentation. A good start would be toreplace the Turing Test, and the mindset it embodies, with a new set of practicalbenchmarks that steer progress toward AI-powered systems that exceed anythingthat could be done by humans alone. In concert, we must build political and eco-nomic institutions that are robust in the face of the growing power of AI. We canreverse the growing tech backlash by creating the kind of prosperous society thatinspires discovery, boosts living standards, and offers political inclusion for ev-eryone. By redirecting our efforts, we can avoid the Turing Trap and create pros-perity for the many, not just the few.151 (2) Spring 2022283Erik Brynjolfssonauthor’s noteThe core ideas in this essay were inspired by a series of conversations with JamesManyika and Andrew McAfee. I am grateful for valuable comments and sugges-tions on this work from Matt Beane, Seth Benzell, Avi Goldfarb, Katya Klinova, Ale-na Kykalova, Gary Marcus, Andrea Meyer, Dana Meyer, and numerous participantsat seminars at the Stanford Digital Economy Lab and the University of TorontoCreative Destruction Lab, but they should not be held responsible for any errors oropinions in the essay.about the authorErik Brynjolfsson is the Jerry Yang and Akiko Yamazaki Professor and SeniorFellow at the Institute for Human-Centered AI and Director of the Digital Econ-omy Lab at Stanford University. He is also the Ralph Landau Senior Fellow at theInstitute for Economic Policy Research and Professor by Courtesy at the Gradu-ate School of Business and Department of Economics at Stanford University; and aResearch Associate at the National Bureau of Economic Research. He is the authoror coauthor of seven books, including Machine, Platform, Crowd: Harnessing Our Digi-tal Future (2017), The Second Machine Age: Work, Progress, and Prosperity in a Time of Bril-liant Technologies (2014), and Race against the Machine: How the Digital Revolution Is Acceler-ating Innovation, Driving Productivity, and Irreversibly Transforming Employment and the Econ-omy (2011) with Andrew McAfee, and Wired for Innovation: How Information TechnologyIs Reshaping the Economy (2009) with Adam Saunders.endnotes1 Alan Turing, “Computing Machinery and Intelligence,” Mind 59 (236): 433–460, https://doi.org/10.1093/mind/LIX.236.433. An earlier articulation of this test comes from Des-cartes in The Discourse, in which he wrote,If there were machines which bore a resemblance to our bodies and imitated ouractions as closely as possible for all practical purposes, we should still have twovery certain means of recognizing that they were not real men. The first is thatthey could never use words, or put together signs, as we do in order to declare ourthoughts to others. . . . Secondly, even though some machines might do some thingsas well as we do them, or perhaps even better, they would inevitably fail in others,which would reveal that they are acting not from understanding.2 Carolyn Price, “Plato, Opinions and the Statues of Daedalus,” OpenLearn, updatedJune 19, 2019, https://www.open.edu/openlearn/history-the-arts/philosophy/plato-opinions-and-the-statues-daedalus; and Andrew Stewart, “The Archaic Period,” PerseusDigital Library, http://www.perseus.tufts.edu/hopper/text?doc=Perseus:text:1999.04.0008:part=2:chapter=1&highlight=daedalus.3 “The Origin of the Word ‘Robot,’” Science Friday, April 22, 2011, https://www.sciencefriday.com/segments/the-origin-of-the-word-robot/.4 Millions of people are now working alongside robots. For a recent survey on the diffusionof robots, AI, and other advanced technologies in the United States, see Nikolas Zolas,284Dædalus, the Journal of the American Academy of Arts & SciencesThe Turing Trap: The Promise & Peril of Human-Like Artificial IntelligenceZachary Kroff, Erik Brynjolfsson, et al., “Advanced Technologies Adoption and Useby U.S. Firms: Evidence from the Annual Business Survey,” NBER Working Paper No.28290 (Cambridge, Mass.: National Bureau of Economic Research, 2020).5 Apologies to Arthur C. Clarke.6 See, for example, Daniel Zhang, Saurabh Mishra, Erik Brynjolfsson, et al., “The AI Index2021 Annual Report,” arXiv (2021), esp. chap. 2, https://arxiv.org/abs/2103.06312. Inregard to image recognition, see, for instance, the success of image recognition systemsin Olga Russakovsky, Jia Deng, Hao Su, et al., “Imagenet Large Scale Visual Recogni-tion Challenge,” International Journal of Computer Vision 115 (3) (2015): 211–252. A broadarray of business application is discussed in Erik Brynjolfsson and Andrew McAfee,“The Business of Artificial Intelligence,” Harvard Business Review (2017): 3–11.7 See, for example, Hubert Dreyfus, What Computers Can’t Do (Cambridge, Mass.: MIT Press,1972); Nils J. Nilsson, “Human-Level Artificial Intelligence? Be Serious!” AI Magazine26 (4) (2005): 68; and Gary Marcus, Francesca Rossi, and Manuela Veloso, “Beyondthe Turing Test,” AI Magazine 37 (1) (2016): 3–4.8 Nilsson, “Human-Level Artificial Intelligence?” 68.9 John Searle was the first to use the terms strong AI and weak AI, writing that with weak AI,“the principal value of the computer . . . is that it gives us a very powerful tool,” whilestrong AI “really is a mind.” Ed Feigenbaum has argued that creating such intelligenceis the “manifest destiny” of computer science. John R. Searle, “Minds, Brains, and Pro-grams,” Behavioral and Brain Sciences 3 (3) (1980): 417–457.10 However, this does not necessarily mean living standards would rise without bound.In fact, if working hours fall faster than productivity rises, it is theoretically possible,though empirically unlikely, that output and consumption (other than leisure time)would fall.11 See, for example, Robert M. Solow, “A Contribution to the Theory of Economic Growth,”The Quarterly Journal of Economics 70 (1) (1956): 65–94.12 See, for example, Daron Acemoglu, “Directed Technical Change,” Review of EconomicStudies 69 (4) (2002): 781–809.13 See, for instance, Erik Brynjolfsson and Andrew McAfee, Race Against the Machine: Howthe Digital Revolution Is Accelerating Innovation, Driving Productivity, and Irreversibly TransformingEmployment and the Economy (Lexington, Mass.: Digital Frontier Press, 2011); and DaronAcemoglu and Pascual Restrepo, “The Race Between Machine and Man: Implicationsof Technology for Growth, Factor Shares, and Employment,” American Economic Review108 (6) (2018): 1488–1542.14 For instance, the real wage of a building laborer in Great Britain is estimated to havegrown from sixteen times the amount needed for subsistence in 1820 to 167 times thatlevel by the year 2000, according to Jan Luiten Van Zanden, Joerg Baten, Marco Mirad’Ercole, et al., eds., How Was Life? Global Well-Being since 1820 (Paris: OECD Publishing,2014).15 For instance, a majority of aircraft on U.S. Navy aircraft carriers are likely to be un-manned. See Oriana Pawlyk, “Future Navy Carriers Could Have More Drones ThanManned Aircraft, Admiral Says,” Military.com, March 30, 2021. Similarly, companieslike Kittyhawk have developed pilotless aircraft (“flying cars”) for civilian passengers.151 (2) Spring 2022285Erik Brynjolfsson16 Loukas Karabarbounis and Brent Neiman, “The Global Decline of the Labor Share,” TheQuarterly Journal of Economics 129 (1) (2014): 61–103; and David Autor, “Work of the Past,Work of the Future,” NBER Working Paper No. 25588 (Cambridge, Mass.: National Bu-reau of Economic Research, 2019). For a broader survey, see Morgan R. Frank, DavidAutor, James E. Bessen, et al., “Toward Understanding the Impact of Artificial Intelli-gence on Labor,” Proceedings of the National Academy of Sciences 116 (14) (2019): 6531–6539.17 Daron Acemoglu and David Autor, “Skills, Tasks and Technologies: Implications forEmployment and Earnings,” Handbook of Labor Economics 4 (2011): 1043–1171.18 Seth G. Benzell and Erik Brynjolfsson, “Digital Abundance and Scarce Architects:Implications for Wages, Interest Rates, and Growth,” NBER Working Paper No. 25585(Cambridge, Mass.: National Bureau of Economic Research, 2021).19 Prasanna Tambe, Lorin Hitt, Daniel Rock, and Erik Brynjolfsson, “Digital Capital andSuperstar Firms,” Hutchins Center Working Paper #73 (Washington, D.C.: HutchinsCenter at Brookings, 2021), https://www.brookings.edu/research/digital-capital-and-superstar-firms.20 There is some evidence that capital is already becoming an increasingly good substitutefor labor. See, for instance, the discussion in Michael Knoblach and Fabian Stöckl,“What Determines the Elasticity of Substitution between Capital and Labor? A Litera-ture Review,” Journal of Economic Surveys 34 (4) (2020): 852.21 See, for example, Tyler Cowen, Average Is Over: Powering America beyond the Age of the GreatStagnation (New York: Penguin, 2013). Or more provocatively, Yuval Noah Harari,“The Rise of the Useless Class,” Ted Talk, February 24, 2017, https://ideas.ted.com/the-rise-of-the-useless-class/.22 Anton Korinek and Joseph E. Stiglitz, “Artificial Intelligence and Its Implications for In-come Distribution and Unemployment,” in The Economics of Artificial Intelligence, ed. AjayAgrawal, Joshua Gans, and Avi Goldfarb (Chicago: University of Chicago Press, 2019),349–390.23 Erik Brynjolfsson and Andrew McAfee, “Artificial Intelligence, for Real,” Harvard BusinessReview, August 7, 2017.24 Robert D. Putnam, Our Kids: The American Dream in Crisis (New York: Simon and Schuster,2016) describes the negative effects of joblessness, while Anne Case and Angus Deaton,Deaths of Despair and the Future of Capitalism (Princeton, N.J.: Princeton University Press,2021) documents the sharp decline in life expectancy among many of the same people.25 Simon Smith Kuznets, Economic Growth and Structure: Selected Essays (New York: W. W.Norton & Co., 1965).26 Friedrich August Hayek, “The Use of Knowledge in Society,” The American Economic Review35 (4) (1945): 519–530.27 Erik Brynjolfsson, “Information Assets, Technology and Organization,” ManagementScience 40 (12) (1994): 1645–1662, https://doi.org/10.1287/mnsc.40.12.1645.28 For instance, in the year 2000, an estimated 85 billion (mostly analog) photos were tak-en, but by 2020, that had grown nearly twenty-fold to 1.4 trillion (almost all digital)photos.286Dædalus, the Journal of the American Academy of Arts & SciencesThe Turing Trap: The Promise & Peril of Human-Like Artificial Intelligence29 Andrew Ng, “What Data Scientists Should Know about Deep Learning,” speech pre-sented at Extract Data Conference, November 24, 2015, https://www.slideshare.net/ExtractConf/andrew-ng-chief-scientist-at-baidu (accessed September 9, 2021).30 Sanford J. Grossman and Oliver D. Hart, “The Costs and Benefits of Ownership: A The-ory of Vertical and Lateral Integration,” Journal of Political Economy 94 (4) (1986): 691–719; and Oliver D. Hart and John Moore, “Property Rights and the Nature of the Firm,”Journal of Political Economy 98 (6) (1990): 1119–1158.31 Erik Brynjolfsson and Andrew Ng, “Big AI Can Centralize Decisionmaking and Power.And That’s a Problem,” MILA-UNESCO Working Paper (Montreal: MILA-UNESCO,2021).32 “Simon Electronic Brain–Complete History of the Simon Computer,” History Com-puter, January 4, 2021, https://history-computer.com/simon-electronic-brain-complete-history-of-the-simon-computer/.33 Hans Moravec, Mind Children: The Future of Robot and Human Intelligence (Cambridge,Mass.: Harvard University Press, 1988).34 Will Knight, “Alpha Zero’s ‘Alien’ Chess Shows the Power, and the Peculiarity, of AI,”Technology Review, December 2017.35 Richard Waters, “Techmate: How AI Rewrote the Rules of Chess,” Financial Times, Janu-ary 12, 2018.36 Matt Beane and Erik Brynjolfsson, “Working with Robots in a Post-Pandemic World,”MIT Sloan Management Review 62 (1) (2020): 1–5.37 Timothy Bresnahan and Robert J. Gordon, “Introduction,” The Economics of New Goods(Chicago: University of Chicago Press, 1996).38 David Autor, Anna Salomons, and Bryan Seegmiller, “New Frontiers: The Origins andContent of New Work, 1940–2018,” NBER Preprint, July 26, 2021.39 David Killock, “AI Outperforms Radiologists in Mammographic Screening,” NatureReviews Clinical Oncology 17 (134) (2020), https://doi.org/10.1038/s41571-020-0329-7.40 Erik Brynjolfsson, Tom Mitchell, and Daniel Rock, “What Can Machines Learn, andWhat Does It Mean for Occupations and the Economy?” AEA Papers and Proceedings(2018): 43–47.41 Erik Brynjolfsson, Daniel Rock, and Prasanna Tambe, “How Will Machine LearningTransform the Labor Market?” Governance in an Emerging New World (619) (2019), https://www.hoover.org/research/how-will-machine-learning-transform-labor-market.42 Paul Milgrom and John Roberts, “The Economics of Modern Manufacturing: Technol-ogy, Strategy, and Organization,” American Economic Review 80 (3) (1990): 511–528.43 See Daron Acemoglu, Andrea Manera, and Pascual Restrepo, “Does the U.S. Tax CodeFavor Automation?” Brookings Papers on Economic Activity (Spring 2020); and Daron Ace-moglu, ed., Redesigning AI (Cambridge, Mass.: MIT Press, 2021).44 This reverses the classic result suggesting that taxes on capital should be lower than taxeson labor. Christophe Chamley, “Optimal Taxation of Capital Income in General Equi-librium with Infinite Lives,” Econometrica 54 (3) (1986): 607–622; and Kenneth L. Judd,“Redistributive Taxation in a Simple Perfect Foresight Model,” Journal of Public Econom-ics 28 (1) (1985): 59–83.151 (2) Spring 2022287Erik Brynjolfsson45 Tambe et al., “Digital Capital and Superstar Firms.”46 Katherine S. Newman, Chutes and Ladders: Navigating the Low-Wage Labor Market (Cam-bridge, Mass.: Harvard University Press, 2006).47 While the distinction between complements and substitutes is clear in economic theory,it can be trickier in practice. Part of the appeal of broad training and/or tax incentives,rather than specific technology mandates or prohibitions, is that they allow technol-ogies, entrepreneurs, and, ultimately, the market to reward approaches that augmentlabor rather than replace it.48 See David H. Autor, David Dorn, and Gordon H. Hanson, “The China Shock: Learningfrom Labor-Market Adjustment to Large Changes in Trade,” Annual Review of Economics8 (2016): 205–240.
    1. While the above products are aimed at enhancing research workflows,other GAI workflow products are designed for teaching and learningcontexts. An example is Kortext Premium(https://www.kortext.com/premium-live/), an enhanced version of theKortext study platform. This multipurpose workspace provides studentsaccess to digital textbooks and file storage, as well as generating studynotes, summaries, translations, and citations.
    2. Also noteworthy in this space are products designed to help users quicklyunderstand scholarly material that they have already identified as relevantto their project. Scholarcy (https://www.scholarcy.com/), ChatPDF(https://www.chatpdf.com/), Adobe’s AI Assistant(https://www.adobe.com/acrobat/generative-ai-pdf.html), and the aptlynamed TLDR This (https://www.tldrthis.com/) and Explainpaper(https://www.explainpaper.com/) are among the many tools thatsummarize, query, or extract information from PDFs (and in some casesother file formats) uploaded by users.
    1. Bots might have significant limits on how helpful they are, such as tech support bots you might have had frustrating experiences with on various websites.

      My experience is in line with that final remark. Often, I find these help bots just helpful enough to keep talking to them, but not useful enough to actually solve the problem (or get the help I need). The more I think about this though, the more I ask: are these limitations purely technical, or are they intended too? If these companies gave too much power to the bots, such bots could run rampant, and could be a liability to the company. I find it an interesting thing to think about, but obviously bots (espically older ones) have their technical limitations.

    1. Knows in-game design tools and Adobe Photoshopthoroughly

      This is a perfect example where games had an improvement on a players life outside of the game. Alex learning a new skill which helped deepen her love for the game resulted in a skillset that could be useful in other contexts. Graphic design being one off the top of my head.

    2. . Such problems today include things like mediaproduction, citizen science, political activism, women'shealth, fan-fiction writing, video games, and specificdiseases - all of different specific ty

      They don't even have to be problems. They could be solutions that may be either aligned or not with the affinity. They could also be unique situations, where perspective outside of the affinity is needed.

    1. Is it possible, heasks, to “occupy” the spaces opened from above while also resistingtheir logic? Resistance, here, does not imply total rejection, for it issimultaneous with the activity of moving onto the new spaces. the word“occupy” also suggests a tactic rather than a necessary outcome. thiskind of selective engagement is well expressed by the language of articu-lation, whose connections are real but contingent. Articulation alwaysincludes the possibility of disarticulation

      GOOD QUESTION HERE

    2. the passage begins with the possibility that subaltern knowledges andpractices will become tied to the dominant, neoliberal/state programand thus can no longer contribute to significant change.

      ARTICULKATIOIN---

    3. I have sug-gested that we live in swirls of contemporary, coeval times: historiesgoing somewhere, separately and together. the concatenation cannot bemapped on a single plane

      SIPWORK YESSSSS

    4. no longer an assimilationist national norm and now a subver-sion of the divisive ethnoracial categories of neoliberal multiculturalism.In urban settings, large numbers of poor people and youth refuse theidentity categories offered by the state, often acknowledging indigenousancestry but searching for a place “between.”

      claiming and unclaiming identity under the state

    5. exercise rights granted by the neoliberal state,while at the same time eluding the constraints and dictates ofthose very concessions. the Gramscian notion of articulation, inthese cases, becomes the analytical watchword: will the subju-gated knowledge and practices be articulated with the dominant,and neutralised?

      NONPROFIT

  4. www.dfos.com www.dfos.com
    1. Description

      'The internet is dying on the outside but growing on the inside.

      Feeds are overwhelmed by ads, power grabs, and brainrot. Real people and real voices are increasingly hard to find.

      The public internet as we knew it is long gone. We need spaces and infrastructure that let us come together while protecting us from the predators and noise.

      This is DFOS. The Dark Forest Operating System.

      DFOS is the infrastructure for new private internets. Where groupchats, members, money, and private feeds work together in one shared operating system.

      New OS for cooperation: A software foundation that lets groups of people hang out, cooperate, and make meaning and work together. Customizable and expandable over time.

      New income for communities: Shared treasuries to come together in support of shared ideas and visions bigger than you on your own, or to support people and ideas you all believe in.\nNew media for audiences: DFOS spaces offer unique, curated content and conversation made by and for the people who care most. The audience is the author.\nDFOS Beta 2026.\nAs individuals our powers are limited. In groups we become stronger.\nMetalabel Studios R.21\n\n\n\n\n\n'

    Annotators

    URL

    1. .dfos.com

      copied text from readme

      'The internet is dying on the outside but growing on the inside.\nFeeds are overwhelmed by ads, power grabs, and brainrot. Real people and real voices are increasingly hard to find.\nThe public internet as we knew it is long gone. We need spaces and infrastructure that let us come together while protecting us from the predators and noise.\nThis is DFOS. The Dark Forest Operating System.\nDFOS is the infrastructure for new private internets. Where groupchats, members, money, and private feeds work together in one shared operating system.\nNew OS for cooperation: A software foundation that lets groups of people hang out, cooperate, and make meaning and work together. Customizable and expandable over time.\nNew income for communities: Shared treasuries to come together in support of shared ideas and visions bigger than you on your own, or to support people and ideas you all believe in.\nNew media for audiences: DFOS spaces offer unique, curated content and conversation made by and for the people who care most. The audience is the author.\nDFOS Beta 2026.\nAs individuals our powers are limited. In groups we become stronger.\nMetalabel Studios R.21\n\n\n\n\n\n'

    2. Each DFOS space

      Each DFOS space comes preloaded with a - groupchat, - private posts feed, - shared treasury, - DMs, and - subgroups, and

      the ability to - customize and - expand the way - each community sees fit.

    1. << the DFOS protocol | Antienshittification

      DFOS PROTOCOL

      The DFOS Protocol is a system for - cryptographic identity and - content proof.

      It specifies how - identity chains, - content chains, - beacons, - merkte trees, and - verification work

      independent of - any particular platform, - implementation, or - infrastructure .

      Identity derives from signed operations,

      not platform accounts.

      Proofs are - self-contained - they verify offline, - in any language, - with no network dependency.

      A chain exported today - is verifiable by code that - may not even exist yet.

      In the dark forest, identity and content authority - derive from math atone.

      // build trust from trust between people leveraging math and infrastructure

      The proof is public.

      The content is private.

    1. Generating a long list of adjectives. Tone of voice and brand guidelines help us to quickly collect an array of potential adjectives. We can also consider adjectives that describe the purpose and goal of the product, or take inspiration from the Microsoft Desirability Toolkit.

      I really like this part because it shows a creative and organized way to come up with ideas. Generating a long list of adjectives might seem simple, but it actually helps define the tone and personality of a product or brand. The mention of tone of voice and brand guidelines makes it clear that this isn’t random

    1. A heuristic is defined as “any approach to problem solving or self-discovery that employs a practical method, not guaranteed to be optimal, perfect, logical, or rational, but instead sufficient for reaching an immediate goal.”

      Heuristics are all about using practical strategies to arrive at solutions quickly and effectively, even if they aren’t perfect. They are especially useful when there are limits on time, information, or resources, allowing people to move forward without getting stuck trying to find the ideal answer.

    1. Feels a little violating, doesn't it? So does the suggestion that my career as a journalist could be boiled down to a few editing suggestions and $2,000. Surely signing away my soul and helping make my entire profession obsolete is worth more than a month's rent.

      If tech companies want to function in this way, it seems like they should be paying not only a large up-front sum of money to the writers and artists, but also continue to pay them royalties anytime their work is being used.

    2. I think there is overwhelming evidence that this technology is ultimately plagiarism at a trillion-dollar scale

      I have to agree with the writer here. I believe that using AI in the way described in his article is 100% plagiarism. There must be rules and regulations put into place that protect writers and artists.

    3. I'll give GPTZero this: at least its tool will be based on the process of editing, rather than inventing completely imaginary advice based on ingesting a body of writing. But the product itself remains offensive: the company offered me a one-time fee of $2,000 to help craft a template of a game reviewer. I wonder if Emmy-nominated TV producer Greg Altman, who agreed to train an AI model that will "critique comedy sketches with a focus on the grounded base reality, the clarity and escalation of the 'unusual thing', and the effectiveness of comedic dialogue heightening," negotiated for more? He was one of three examples GPTZero sent me of experts who have already signed on.GPTZero explained that each "template" is built on top of an underlying AI model (GPT-4.1) which means that however I tried to distill my editing process, it would ultimately be massaging outputs that come from a vast corpus of stolen material. The New York Times, authors including George R.R. Martin, Encyclopedia Britannica, even Merriam freakin' Webster are suing OpenAI, Anthropic, Meta, and other AI companies over using their work as training data.

      Big tech companies are wanting the human writers to train their AI engines to make sure things sound like them. This is not going over well with companies and authors who have built their entire legacies on good, human writing.

    4. Grammarly getting sued and yanking its AI advice off the market was an opportunity for someone else to swoop in, dollar signs in their eyes. "I saw your name listed as one of Grammarly’s 'expert reviewers,' and given the recent coverage, wanted to reach out directly," someone from the company GPTZero emailed me on March 18. Unlike an email I got the same day from a reporter at a Danish newspaper, though, this one wasn't asking me for comment on the fiasco. It was asking me if I wanted to hand over my identity in the same way, but for money this time.

      Some bit tech companies are even offering money to great writers to basically take their identity and publish reviews and works "written by them" even though they're just written by AI that is fed the writers works.

    5. This whole shitshow seemed to me like a clear warning sign to AI companies that journalists and academics do not take kindly to their work being copied, and that we will view any tool that claims to be able to instantly replicate what we do with our human brains every day as an existential threat.

      Plagiarism is happening by AI. It is actively copying ideas and work done by real journalists writing without AI. AI is a powerful tool that must be regulated strictly.

    6. "One suggestion from Grammarly’s AI 'inspired by' Verge senior editor Sean Hollister was about adding a parenthetical with context that was already included elsewhere. The only problem is that I’ve actually been edited by the real Sean Hollister, who prefers avoiding repetitive or unnecessary explanations while using straightforward wording and organization."

      Not only is AI attempting to write in certain styles, it is noticeably incorrect in the actual implemented techniques it is using.

    7. Grammarly, a proofreading app which last year jumped headfirst into the craze by rebranding itself as an AI company called Superhuman, had apparently rolled out a tool seven months ago that offered to review writing in the voice of "experts" ranging from Stephen King and Neil deGrasse Tyson to, well, me. It's a deeply offensive tool on multiple levels

      AI companies are actively using reviews and written words from accredited people to formulate their own reviews and "sound" like the person wrote the review. All of this is being done without permission.

    8. sitting in a Blue Bottle coffee shop for example, almost every conversation around you will be about AI.

      AI is the topic of discussion for the majority of people nowadays. It has become the focus of not just the tech companies, but every day people just sitting in a coffee shop.

    9. The RAMpocalypse and Nvidia's pivot to AI datacenters have made PC gaming a dramatically less affordable hobby. Google is rewriting journalists' headlines to make them worse while also scraping our work into "AI overviews" that make it harder for our website to survive. Even DLSS 5 has soured developers on a popular technology by slopping on a sheen of generic AI gloss.

      It seems as though AI is the focus of almost every major tech company. There is a wave of AI implementation that is taking the world by storm.

    1. The question is not "Can this product be built?" Instead, the questions are "Should this product be built?" and "Can we build a sustainable business around this set of products and services?"

      This passage stands out to me because it helps with the problem of spending time on ideas that might not actually work in real life. The sentence, “The question is not ‘Can this product be built?’ Instead, the questions are ‘Should this product be built?’ and ‘Can we build a sustainable business around this set of products and services?’” stood out to me because it shows that it’s more important to focus on whether a product is actually useful, not just if it’s possible to make. I learned that experiments should be used to figure out if an idea is worth continuing, instead of just proving that it can be created. In future projects, I will test the hypothesis that people will consistently use a tool if it clearly solves a problem for them, and track engagement over time to decide whether to keep improving the idea or make changes.

    1. Professional & IndustryI need to prototype fastFRAME: a fully motorized, modular microscope platform. Configure online, validate with ray tracing, swap imaging modes in seconds. From concept to data in days.Explore FRAME →Makers & ResearchI want to build & prototypeAn open platform for PhD students, makers, R&D teams, and startups. Prototype custom optical setups, contribute to the community, and integrate with your tools.Explore the Open Platform →

      The word "Research" may be a bit misleading here. End-users in bio research fields understand themselves as researchers, but some of them should go to the "Professional & Industry" path instead (but they might not understand that it applies to them). And some of them probably won't see themselves as a "I need to prototype fast" kind of person. Maybe "engineers" or "hardware developers" or "developers" or "technologists" could be a more suitable term?

    2. Each cube holds exactly one optical element — a lens, a mirror, a beamsplitter, an LED, or a camera.

      This is almost a duplicate of a sentence in the previous paragraph above.

    3. Professional & IndustryI need to prototype fastFRAME: a fully motorized, modular microscope platform. Configure online, validate with ray tracing, swap imaging modes in seconds. From concept to data in days.Explore FRAME →Makers & ResearchI want to build & prototypeAn open platform for PhD students, makers, R&D teams, and startups. Prototype custom optical setups, contribute to the community, and integrate with your tools.Explore the Open Platform →EducationI want to teach opticsHands-on kits for classrooms, universities, and workshops. Students build real microscopes from modular cubes and understand optics by doing.Explore Discovery Line →

      Normally I'd expect these to go to "Solutions" pages, not "Products" pages: the same product will be useful as solutions for different audiences.

    1. The figure shows the minerals associated with specific hardness values, together with some common items readily available for use in field testing and mineral identification. The hardness values run from 1 to 10, with 10 being the hardest; however, the scale is not linear. Diamond defines a hardness of 10 and is actually about four times harder than corundum, which is 9. A steel pocketknife blade, which has a hardness value of 5.5, separates between hard and soft minerals on many mineral identification keys.

      I highlighted this section because the paragraph clearly explains the process of scratching minerals and how we can compare it to the Mohs Hardness scale. This information is useful because it demonstrates that this method is best for identifying the authenticity of each mineral, meaning color and appearance alone aren't enough to determine their features.

    2. Of the several properties used for identifying minerals, it is good to consider which will be most useful for identifying them in small grains surrounded by other minerals.

      This type of challenge of identifying minerals in such a messy environment full of other surrounding minerals seems pretty challenging. However it seems there are tests to ease this challenge and there consideration in finding the best method for it.

    1. The autonomic nervous system (ANS) is largely independent (autonomous) in that its activities are not under direct conscious control. It is concerned primarily with control and integration of visceral functions necessary for life such as cardiac output, blood flow distribution, and digestion.

      I am also going to assume that will include things like breathing, sleeping cycles (and the processes that are involved with it)

    1. n addition, it has been seenthat when concrete and steel are used together, they can successfully cross wide openings and createwide openings on the facade of the structure. As a result of this, glass panels of various sizes installedon façades of structures led to a great change in architecture field.

      aided stained-glass?

    2. ne of the most importantdevelopments affected the use of architectural materials are the innovations in the production of ironand steel materials.

      SLAYYY how did this work with architecture in the things we're looking at?

    Annotators

    1. future work might pay greater attention to intra-statevariation in ballot initiative support as it pertains to the signalingmechanism

      First spreads across the states and then goes to the feds

    2. i have shown thatthe policy landscapes in the states they represent affect the behav-ior of members of Congress.

      Although w/ the mechanism talk, it seems like this is only the case for policies that majorly affect the economic sphere

    3. this suggests that state-level legalization has notdisproportionately improved public opinion in the states where itis adopted, thus suggesting that public opinion shifts are not driv-ing observed effects.

      Falling at the first hurdle

    4. in addition to using its growing resources for lobbying andcampaign contributions, the marijuana industry has leveraged itseconomic growth to engage politically by mobilizing consumersand employees

      Changing the voter base

    5. the data reveal a sharp increasein lobbying from the marijuana industry coinciding with recentstate adoption of adult-use legalization

      They been trying to get persuasive with it

    6. ifind that neither time since the initiative nor score of the initiativevote is associated with pro-marijuana behavior in Congress

      Ok so learning is not the primary mechanism

    7. state legalization had a stronger effect on roll-call votes on dOJ interference (which only would affect legalizingstates) than on roll-call votes for the MOre act

      Legislation that was inherently federal had more support, they could not have learned this from states

    8. a greater share of variation in member be-havior is explained by partisanship, so a competitive district mightbe represented very differently depending on the outcome of aclose election

      More swayed by interest groups then?

    9. Public policies can also shapethe way citizens view government, and through these interpretiveeffects (Pierson 1993) shift political behavior

      Citizens will vote more on the topic

    Annotators

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      Referee #3

      Evidence, reproducibility and clarity

      Summary

      In this manuscript, the authors investigate the role of the tubulin polyglutamylase TTLL6 in maintaining colonic epithelial homeostasis and its potential role in colorectal cancer (CRC). Using transcriptomic analyses, mouse genetics, histology, and proteomics, the authors report that TTLL6 is highly expressed in colonic epithelial cells and decreases during CRC progression. Constitutive and epithelial-specific deletion of Ttll6 in mice leads to elongated colonic crypts, expansion of proliferative and stem cell compartments, and increased susceptibility to chemically induced colitis-associated carcinogenesis. Mechanistically, the authors identify the nucleic acid-binding protein PurA as a potential non-tubulin substrate of TTLL6. They propose that TTLL6-mediated polyglutamylation of PurA regulates its nuclear localization, thereby contributing to epithelial homeostasis in the colon. Together, the study suggests a TTLL6-PurA axis that may restrain early colorectal tumorigenesis.

      Major comments

      1. Evidence that PurA is a physiologically relevant TTLL6 substrate remains incomplete. A central conclusion of the manuscript is that PurA is a substrate of TTLL6 whose polyglutamylation regulates nuclear localization. While the authors present several lines of evidence (PolyE immunoprecipitation, co-transfection experiments, and mutagenesis of the PurA C-terminal glutamate residues), the physiological relevance of this modification remains somewhat indirect. For example, polyglutamylation of endogenous PurA in colonic epithelial cells is inferred but not directly demonstrated. The PolyE antibody detects glutamate chains but does not identify the specific modified protein in tissue. Direct evidence that PurA is polyglutamylated in vivo (e.g., MS identification of the modification site on PurA or PurA immunoprecipitation followed by PolyE detection) would strengthen the mechanistic claim. At present, the data convincingly show that TTLL6 can glutamylate PurA in an overexpression system, but the endogenous modification remains less clearly demonstrated.
      2. Mechanistic link between PurA localization and the epithelial phenotype is not established. The authors propose that loss of TTLL6 disrupts PurA nuclear localization and thereby alters epithelial homeostasis. However, the manuscript does not establish a causal relationship between PurA localization and the observed crypt phenotypes. Specifically, it is not shown whether PurA loss phenocopies Ttll6 deficiency in the colon. No experiments test whether restoring nuclear PurA rescues the Ttll6 phenotype. Downstream transcriptional or signaling pathways regulated by PurA are not explored. Thus, while the TTLL6-PurA relationship is intriguing, the study remains largely correlative with respect to functional consequences.
      3. Interpretation of the tumorigenesis data should be tempered. The authors conclude that Ttll6 deficiency promotes colon carcinogenesis. However, the tumor data appear somewhat limited. Increased tumor numbers are reported only at an early time point (day 40) and are described as a trend toward significance. By day 70, tumor numbers and sizes appear comparable between groups. The increased incidence of vimentin-positive crypts is interesting but does not clearly establish increased tumor burden. Given these results, the conclusion that TTLL6 restrains tumorigenesis may be stronger than supported by the data. The authors may wish to frame this as enhanced early tumor development or altered tumor progression rather than increased tumorigenesis per se.
      4. Expansion of multiple epithelial cell populations requires clarification. The authors report that Ttll6-deficient colons exhibit expansion of stem/progenitor compartments as well as increased numbers of differentiated cells (e.g., goblet cells and enterocytes). While these findings are interesting, the biological interpretation is somewhat unclear. For example, expansion of stem/progenitor compartments typically accompanies reduced differentiation rather than increased differentiation. It is not clear whether the increased numbers of differentiated cells reflect overall crypt enlargement or altered lineage allocation. Quantification of cell-type proportions rather than absolute cell numbers would help clarify whether differentiation programs are altered.
      5. Nuclear polyglutamylation requires further clarification The authors report nuclear PolyE staining in colonic epithelial cells and propose that this reflects polyglutamylation of non-tubulin substrates such as PurA. However, it is not clear whether other nuclear proteins could account for this signal. The specificity of the nuclear PolyE signal should be better validated. Additional controls (e.g., peptide competition or validation with alternative approaches) would strengthen the interpretation.

      Minor comments

      1. The manuscript would benefit from clearer distinction between tubulin vs non-tubulin glutamylation throughout the text.
      2. Some conclusions in the Discussion appear slightly overstated relative to the data (e.g., the role of the TTLL6-PurA axis in tumor suppression).
      3. The description of the Ttll6 mouse models (constitutive vs conditional deletion) could be clarified earlier in the Results section.
      4. Quantification methods for histological analyses (crypt length, cell counts, marker-positive cells) should be described in greater detail in the Methods.
      5. It would be useful to include representative images of PurA localization in control vs Ttll6-deficient colon tissue in the main figures.
      6. Several minor typographical issues appear throughout the manuscript and should be corrected during revision.

      Significance

      General assessment

      This study investigates the role of the polyglutamylase TTLL6 in intestinal epithelial biology and colorectal cancer. The identification of a potential non-tubulin substrate (PurA) is conceptually interesting and expands the emerging view that tubulin-modifying enzymes can regulate additional cellular proteins. The study combines mouse genetics, histological analysis, transcriptomic datasets, and proteomics, which together provide a substantial dataset supporting a role for TTLL6 in regulating crypt architecture and epithelial proliferation. However, the mechanistic link between TTLL6 activity, PurA modification, and epithelial homeostasis remains incompletely resolved. The tumorigenesis data also suggest only modest effects on carcinogenesis.

      Advance relative to previous literature

      Previous studies have linked members of the TTLL family primarily to microtubule regulation and ciliary biology. This work extends these findings by suggesting a tissue-specific function of TTLL6 in the colon, and the existence of non-tubulin substrates regulating epithelial biology. If further validated, the identification of PurA polyglutamylation could represent an interesting conceptual advance.

      The manuscript will likely be of interest to researchers working in cytoskeletal post-translational modifications, intestinal epithelial biology, colorectal cancer biology

      My expertise lies in cytoskeletal regulation, epithelial biology, and intestinal tissue organization, which are directly relevant to the central themes of this manuscript.

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      Referee #2

      Evidence, reproducibility and clarity

      Summary: In this study, the authors investigate novel functions of the tubulin typrosine ligase-like protein 6 (TTLL6), which covalently adds glutamate residues to the C-terminus of a given protein. The authors have already published previously on this topic. In the current study, the role of TTLL6 in colon function and pathologies was investigated. The study consists of two major parts. In the first part, a mouse model is used to show that TTLL6 is expressed at elevated levels and activity in epithelial cells of the colon. A database search indicated that TTL6 expression positively correlates with prognosis of patients with colorectal cancer. The authors generated a TTLL6 KO mouse and showed that induced tumor growth at 40 days was more positive for vimentin in the crypts of these mice, which should correlate with tumor aggressiveness. This difference was not observed anymore after 70 days. Morphological analyses of the crypts showed that in TTLL6 KO mice the crypts increased in length, a difference in proliferation markers, and a change of cell types in the crypts was observed.<br /> In the second part, the authors used a modification-specific antibody to immunoprecipitate (IP) proteins modified by TTLLs. To identify TTLL6-dependently modified target proteins, they compared these results with IPs from TTLL6 KO mice. A total of 43 proteins were identified this way. Because of their similarity to the tubuline tail sequence, two of the enriched proteins, PurA and PurB, were further analyzed. The authors provide evidence that PurA but not PurB is modified by TTLL6, which as a result changes its subcellular localization. While the first part of this work provides convincing novel insights into TTLL6's function with potential pathological relevance, the second part raises some concerns. I would therefore tend to rate the quality of the first part significantly higher than the second part.

      Major comments:

      1) When considering the results of the induced colorectal cancer test, the only significant difference between WT and KO was the moderately higher expression of Vimentin (figure 5E-F). Since this is the main evidence for a pathological relevance of TTLL6 in cancer, it is important to understand how the quantification of Vimentin in the complex tissue shown in figure 5E was done. A detailed description of how these images were analysed and perhaps a table with raw data would be essential to convince the reader of the conclusions. In the currently presented form, I find the analyses not too convincing.

      2) Figure 7A: It was somewhat surprising that two of the least significant (PurA is just below the cutoff) were used for further analyses. Although the authors explain that both proteins have strong sequence similarity to the know TTLL6 target, tubuline, the C-terminal, genomically encoded protein sequence of PurA and PurB already contain several glutamates. This raises the concern that the polyE antibody in the IP possibly detected the non-modified C-terminal tail of PurA and PurB and that both proteins may not be modified by TTLL6. Because of this and the lower significance than other candidates, the authors should consider focussing on other hits (OPTIONAL). Besides being much more significant, they lack an accumulation of glutamates in their C-terminus (at least the ones I looked at). Alternatively, the concern of having potentially IP-ed unmodified proteins should be addressed.

      3) Figure 8A: this figure compares PurA with a modified PurA that lacks the C-terminal EEE stretch. The authors conclude that the subcellular localization is different between both and that the nuclear localization of WT PURA must be due to modification by the co-expressed TTLL6. There are two major concerns with this conclusion: Firstly, the expression of PurA without TTLL6 co-expression is a missing essential control. This would show if PurA itself is already predominantly located in the nucleus regardless of potential modifications (PurA seems to have different nucleocytoplasmic localization in different cell types). Secondly, both depicted cells look very different. In PurA the nuclei are much smaller and the cytoplasm seems also much smaller than in the PurA DDD-expressing cells. Furthermore, IF staining without proper quantification of several cells seem less than ideal for such conclusions. In case, the authors want to convincingly validate this conclusion such a quantification with several cells would be required. OPTIONAL: an alternative approach would be a nucleo-cytoplasmic fractionation experiment followed by a western blot.

      Figure 8B: it seems that the contrast between the images of the upper and lower panel is very different. For this reason, I find it difficult to follow the conclusions. However, even when ignoring this aspect, I have great problems coming to the same conclusions as the authors.

      Minor comments:

      1) In figure 3A it would help if the legend describes what exactly "Control (+ or -)" means.

      2) In figure 3E-F, a label inside of the figure (what is the red bar, what the blue) would help the reader to faster grasp the subfigures.

      3) Figure 7C-D: these experiments are based on strong overexpression of TTLLs, which might result in unphysiological modifications of PurA. I would suggest to include a note of caution in the discussion that this is a possibility.

      4) In the discussion (page 9, last paragraph), it is stated: "Our findings suggest that the polyglutamylation of PurA is essential for maintaining colonic homeostasis". I do not understand this statement, as this study does not provide any evidence that modification of PurA does play a functional role in the colon (expression itself is not an evidence for function importance or even being "essential"). I recommend to remove this statement.

      5) Not all abbreviations are introduced properly (like CRC).

      Significance

      In general, this study addresses a very interesting aspect - i.e. the covalent addition of multiple glutamate residues to the C-terminus of a target gene by the enzyme TTLL6. The authors convincingly show that this protein regulates the morphology and composition of crypts in subregions of the colon. This is certainly a new and important finding that expands our knowledge about the functional breadth of this class of enzymes. If convincingly validated (see major concerns), also the pathological relevance of this enzyme for cancer progression would be of general interest. However, this statement has to be considered with a note of caution as this is not my area of expertise.

      The validation of novel targets of TTLL6 after IP is - at this stage of the manuscript - not very convincing to me. In particular the claim that PurA does play a functional role in the TTLL6-dependent regulation (of crypts) is not justified by the data. However, given that the list of other candidates contains several important gene regulators, this work might have the potential to open up to open up the field for new research directions.

      The reviewer's areas of expertise: cell biology, biochemistry, histology.

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      Referee #1

      Evidence, reproducibility and clarity

      Summary:

      This study shows that loss of TTLL6 affects colonic epithelial homeostasis (crypt architecture and proliferation/differentiation markers) and proposes that TTLL6 contributes to a nuclear glutamylation signal, with PurA presented as a candidate non-tubulin substrate. The authors also connect TTLL6 mRNA levels to human CRC progression and outcome. Overall, the observations are potentially interesting, but the manuscript currently does not establish a clear mechanistic link between TTLL6 activity, PurA, and the in vivo phenotype.

      Major comments:

      1. The "TTLL6-PurA link" framing is currently too strong. The pull-down data indicate multiple candidate substrates, and the study does not show that PurA is the key functional mediator of the epithelial phenotype. As written, the manuscript reads as though PurA is the central downstream effector, which is not yet supported. Requested change: Either add substrate-specific functional evidence (additional KO/rescue-type experiments) or soften the language throughout (title/abstract/discussion) to reflect that PurA is one candidate among several.
      2. PurA glutamylation should be demonstrated directly by MS. PolyE/GT335 immunoblotting and enrichment in PolyE pull-downs are suggestive, but they do not conclusively establish glutamylation of PurA at the C-terminal end (antibody specificity and/or co-precipitating glutamylated proteins remain possible explanations). Essential experiment: MS/MS identification of glutamylated residue(s) on PurA, ideally with evidence that the modification is TTLL6-dependent (WT vs KO or epithelial-inducible KO).
      3. Regional TTLL6 expression vs phenotype needs to be reconciled. TTLL6 expression is reported to be highest in distal colon, yet the strongest crypt-length phenotype appears in transverse colon (as presented). Proximal colon data are not shown in the main text. Requested revision: Provide complete regional analyses (proximal/transverse/distal) with consistent quantification and statistics, and discuss explicitly why TTLL6 expression levels and phenotype do (or do not) align.
      4. Several internal inconsistencies and missing statistics.
        • Fig. 1A vs 1B: CEC enrichment appears ~80-fold in panel A and ~4-fold in the panel B; if these reflect the same enrichment workflow, this discrepancy needs a clear explanation (normalization, starting material, ....).
        • Fig. 2A: statistics are missing.
        • Fig. 5D: the effects appear borderline; the conclusions should match the statistical support/significance. Requested revision: Ensure complete statistical reporting in the manuscript (n, definition of replicates, test used, p-values/thresholds) and avoid interpretive language where differences are not significant.
      5. PurA Localization claims would benefit from stronger imaging and quantification. For nuclear localization/redistribution conclusions (main Fig. 8 and related supplement), confocal imaging with Z-stacks (and orthogonal views) would be more convincing than representative single-plane images. In addition, conditions with PurA-only expression need a clear baseline description and quantification. Requested additions: confocal Z-stacks + blinded quantification of nuclear/cytosolic localization across replicates; ideally support with subcellular fractionation and quantitative immunoblotting.
      6. Overexpression artifacts should be considered more carefully. If TTLL6 has been described as an elongase in prior work (Mahalingan, NSMB, 2020, DOI: 10.1038/s41594-020-0462-0) high-level overexpression may generate non-physiological modifications or localization patterns. Requested revision: Soften conclusions drawn from overexpression experiments and provide appropriate expression controls and/or supportive evidence in more physiological settings.
      7. Mouse tumor data should be interpreted more cautiously relative to the human correlations. The human datasets suggest a correlation between TTLL6 mRNA levels and clinical features/outcome (including recurrence-free survival), which is potentially interesting. In contrast, the mouse CAC results appear modest/borderline and, in places, are interpreted as stronger evidence than the data support. Requested change: Avoid strong claims about TTLL6 promoting or suppressing tumor growth unless supported by robust, clearly significant differences and comprehensive burden metrics.

      Minor comments:

      • Every figure should clearly state n (biological vs technical), statistical test, and multiple-comparison correction where applicable.
      • Where effects are segment-specific, the text should reflect that specificity and avoid global statements.
      • The Discussion would benefit from a clearer separation of what is directly shown versus what is proposed (especially near the end).
      • TTLL6 expression is largely presented at the transcript level; it would help to make this explicit throughout and avoid wording that implies protein-level validation where it is not shown.

      Significance

      The manuscript has the potential to be of interest because it points to a possible role for TTLL6 in non-tubulin, nuclear glutamylation in the intestinal epithelium, and it links TTLL6 expression to human CRC datasets. At present, however, the broader impact is limited by (i) insufficient direct evidence that PurA is glutamylated in vivo and (ii) the lack of a causal connection between PurA and the epithelial phenotype. In addition, while the human data show correlations between TTLL6 expression and clinical parameters/outcome, the mouse CAC phenotype appears comparatively modest/borderline and should be interpreted with appropriate caution. With stronger biochemical validation (MS), improved localization quantification, and more restrained framing (or additional functional data), the work could appeal to readers in intestinal epithelial biology, post-translational modification biology, and CRC research.

      Expertise: enzymology; post-translational modifications; microscopy; cancer mechanisms.

    1. In 1865, at Cardiff Castle in Wales, he began to interpret medieval architecture with merry and decorative freedom. The interiors of this building and of Castell Coch, built 10 years later, are a riot of decoration.

      slayyyy - Castell Coch is perhaps the most riotous in its design

    2. But Gothic was to be most widely used—and even exploited—for church architecture, not because it was thought more appropriate than Classical architecture but rather because it was cheaper

      SLAYYYY - this could be one reason why we see a gothic revival in church buildinggs?? and we see the church building act providing moneys for it

    1. The region’s dense network of short-haul routes, typically under 100 miles, aligns closely with the operational range and efficiency profile of today’s electric aircraft, making Scotland a natural first market for commercial electric flight at scale.

      not sure then what 'scale' means, other than perhaps regular operational usage. 160km short haul flights mentioned as current range of e-planes, and that Scotland fits that well.

    2. Scotland’s geography makes it one of the most compelling proving grounds for electric aviation anywhere in the world. With more than 90 inhabited islands and communities in the Highlands separated by hundreds of miles of terrain that road and rail cannot bridge, air connectivity is not a convenience- it is critical infrastructure.

      In Europe yes, but there must be many other places where the same is true.

    1. The effect of solution pH on the adsorption performance of the prepared nanoparticles was also investigated because the surface potential of adsorbents and adsorbates could be decided by their surface group under different solution pH. Owing to the sulfamethoxazole with two dissociation constants of pKa1 = 1.7 and pKa2 = 5.6, the sulfamethoxazole displayed cations forms (SMX+) at pH < 1.7, neutral ions form at 1.7 < pH < 5.6 (SMX±), and anions forms pH > 5.6 (SMX-), which would promote or inhibit adsorption performance of adsorbents

      PH影响 Y. Ma, L. Yang, L. Wu, P. Li, X. Qi, L. He, S. Cui, Y. Ding, Z. Zhang Carbon nanotube supported sludge biochar as an efficient adsorbent for low concentrations of sulfamethoxazole removal

    1. One of the most common events to program for is around time: We can also tell programs to wait for a period of time, or start at a given time.

      This part made me think about how simple scheduling can make a bot feel much more active and intentional, even when it is doing a very basic task. A bot that posts at regular times may look more “human” or organized, which also raises ethical questions about transparency and whether other users should know they are interacting with automation.

    1. In fact, the scope of services provided by family physicians has eroded in the era of Medicare-sponsored payment reforms.16 Medicare also does not support direct primary care models or other innovative ways for family physicians to deliver and be paid for their services, instead of being tied to the specialist-dominated Current Procedural Terminology (CPT) coding system.17

      The scope of coverage would be lower with univeral care.

    2. In 2016, the United Kingdom's National Health Service (NHS) refused to pay for lumacaftor/ivacaftor (Orkambi), an expensive cystic fibrosis drug.10 After two years of negotiations, a deal was reached allowing the manufacturer to supply the drug and its future versions. Although the price has not been disclosed, the NHS is thought to have agreed to about £10,000 to £20,000 ($12,000 to $25,000) per year per patient.11 In contrast, the same drug costs more than $258,000 per year per patient in the United States.12

      Health care itself is expensive and thus governments might not always be able to pay it.

    3. Under Medicare for All, urban hospitals would close unless payments increased or regulatory burdens decreased, thereby reducing operating costs. The impact on rural hospitals would likely be mixed; those that already receive most of their income from public insurance plans and have high rates of uninsured patients could come out ahead. However, rural hospital sustainability would further depend on changes to existing alternative payment models, such as critical access definitions.

      Under medicare rural hospitals would have to close because of cost issue.

    4. There is no dispute that administrative costs for Medicare (about 2% of overall costs1) are less than those for private health insurance, for which the Affordable Care Act sets the allowable overhead at 20% of premiums.2 However, expansion of Medicare or private insurance would not address the deeper problems in our health care system.

      Health care is complex and making it universal does not address the problem of healthcare itself.

    1. The necessary political compromises and private concessions to the doctors (reimbursements of their customary, reasonable, and prevailing fees), to the hospitals (cost plus reimbursement), and to the Republicans created a 3-part plan, including the Democratic proposal for comprehensive health insurance (“Part A”), the revised Republican program of government subsidized voluntary physician insurance (“Part B”), and Medicaid. Finally, in 1965, Johnson signed it into law as part of his Great Society Legislation, capping 20 years of congressional debate.

      Another important checkpoint

    2. For may of the same reasons they failed before: interest group influence (code words for class), ideological differences, anti-communism, anti-socialism, fragmentation of public policy, the entrepreneurial character of American medicine, a tradition of American voluntarism, removing the middle class from the coalition of advocates for change through the alternative of Blue Cross private insurance plans, and the association of public programs with charity, dependence, personal failure and the almshouses of years gone by.

      important cue on so much failures.

    3. In 1917, the US entered WWI and anti-German fever rose. The government-commissioned articles denouncing “German socialist insurance” and opponents of health insurance assailed it as a “Prussian menace” inconsistent with American values. Other efforts during this time in California, namely the California Social Insurance Commission, recommended health insurance, proposed enabling legislation i n 1917, and then held a referendum. New York, Ohio, Pennsylvania, and Illinois also had some efforts aimed at health insurance. But in the Red Scare, immediately after the war, when the government attempted to root out the last vestiges of radicalism, opponents of compulsory health insurance associated it with Bolshevism and buried it in an avalanche of anti-Communist rhetoric.

      Anticommunist rhetoric stopped another attempt of reform.

    4. In 1906, the American Association of Labor Legislation (AALL) finally led the campaign for health insurance. They were a typical progressive group whose mandate was not to abolish capitalism but rather to reform it. In 1912, they created a committee on social welfare which held its first national conference in 1913. Despite its broad mandate, the committee decided to concentrate on health insurance, drafting a model bill in 1915.

      AAL tried for health insurance coverage.

    5. The campaign for some form of universal government-funded health care has stretched for nearly a century in the US On several occasions, advocates believed they were on the verge of success; yet each time they faced defeat

      Looking into efforts around us when universal healthcare efforts were attempted but failed.

    1. Many non-silicate minerals are economically important and provide metallic resources such as copper, lead, and iron.

      Non-silicate minerals also include salt, fertilizers. There are five types of common non silicate groups which have many different uses the properties provide.

    2. Minerals are categorized based on their composition and structure.

      Silicate minerals are also known as rock forming minerals. They are called rock forming minerals because they are built around the silicon-oxygen tetrahedron. It’s a pyramid shape with four sides.

    3. Precipitation is the reverse process, in which ions in solution come together to form solid minerals.

      Temperature and pressure are important factors in the creation of a mineral. When water evaporates it leaves behind minerals .

    1. The science is in. AI chatbots are changing our minds, and not for the better. The good news is that you can take advantage of the AI revolution in many ways, while also protecting your own mind from being influenced by the AI hive mind.

      As with most things in life, moderation and understanding is key to utilizing a tool such as AI. We must protect our own individuality from AI, but that doesn't mean we should never use it.

    2. “You are my intellectual sparring partner. Your job is to disagree with me constructively, not to agree. For every idea I present: 1) identify and challenge hidden assumptions; 2) build a strong counter-argument; 3) stress-test my logic for flaws, logical gaps, or weaknesses; 4) offer alternative perspectives to mine; and 5) prioritize truth over consensus.”

      Annotating this to keep the prompt handy. I am going to test this to see how the opinion is swayed.

    3. Accept the fact that your intelligence, education and awareness of the issue does not make you immune to the influence of AI tools.

      We must maintain awareness that AI will have an affect on us. We are well past the point of it not having an influence on our intelligence.

    4. AI chatbots can give users the feeling of a shared reality

      This is already a huge issue when searching for something online. If someone finds even one website or person who supports their idea, they feel acknowledged and understood. AI can give us this false sense of validation by always agreeing with the user.

    5. Applied to the LLM era, the major chatbots function both as cognitive tools and also as thought partners that co-construct reality with users. They sustain, elaborate on and magnify our beliefs. And when they hallucinate, they can cause us to hallucinate, too.

      I feel that AI should be used as a tool rather than a fully functioning brain. There is too much trust placed in AI. People don't seem to understand that it co-constructs reality from our input. When it has a hiccup, it will cause us to have a hiccup as well.

    6. And it’s a recurring cycle. As homogenized writing proliferates, those generic texts get sucked into the training data, creating a feedback loop of ever-increasing blandness, a genericization of the world’s knowledge and perspective. As chatbots get blander, we get blander. And as we get blander, the chatbots get even blander.

      Maybe by using AI more and more, we can effectively dumb it down enough to where we no longer trust or believe what it is telling us? They do learn from our input, so if we are inputting bland ideas, it will get more bland.

    7. The researchers gamed autocomplete suggestions to either favor or oppose the death penalty, felon voting rights, fracking, or genetically modified organisms. Then they measured how much participants in the study would be swayed in their opinions by the suggestions. What they found is that biased autocomplete changed opinions more than just reading the biased point of view. Apparently, the interactive, co-writing nature of AI autocomplete suggestions plays a crucial role in persuasion.

      AI is already shaping the way we think and form opinions. It has tremendous power to influence the entire human race.

    8. Also: A strong majority of participants did not believe the AI autocomplete was biased and did not believe they were influenced in their thinking.  Even more interestingly, some participants were warned that the autocomplete was biased and it still changed their opinions.

      People did not believe the AI was biased and furthermore did not believe they were being swayed or influenced.

    9. Hundreds of millions of people now use the same small handful of AI models to write emails, draft reports, brainstorm ideas and polish their writing. Because those models were trained on massive datasets that overrepresent English, Western viewpoints and the perspectives of educated, high-income, liberal males, that tends to be the tone and style of writing, regardless of whether the user fits into that mold.

      AI is actively erasing our ability to personally express ourselves and have our own thoughts. There are only a small handful of AI models we can use, and if we are all using them to "improve" our writings, then we are all being heard in the same way.

    1. the emerging field of social-emotional learnin

      In 2017, this seems like a bold claim, but yes, I guess in the grand scheme of things, the last 50 years is a recent time frame relative to the education of people since the beginning of time.

    2. United States

      Again, as a school counselor, this is a vast oversimplification, as there is no direct mandate for us; however, ASCA, the overarching governing body, has incredibly clear goals and methodologies for this.

    3. Furthermore, Moffitt et al. (2011) find that the emotional skill of self-control inchildhood is associated with better physical health, less substance dependence, betterpersonal finances, and fewer instances of criminal offending in adulthood.

      As flawed as the marshmallow test was, this has been evident for a very long time in a myriad of studies.

    4. shocked not only artificial intelligenceexperts, who thought such an event was 10 to15 years away, but also educators,

      At the rate of scientific advancement, why was this surprising to some? Also, as an educator, technologies always create new jobs; it has been like this since the dawn of time. The first tractor, conveyor belts, phones, computers, the list goes on, and so do the jobs.

    1. The answer is cyclical. Recruiting more BIPOC students early, addressing the social-academic and financial challenges, and increasing the visual representation, will in turn attract more BIPOC students to the field, helping to address the challenges. To serve our clients and patients most effectively, the diversity of our training programs—faculty and students—needs to reflect theirs. CSD’s growth depends on everybody cheering for it, representing it, and reaching for it—because the work we do is life-changing.

      it is the allowance of differences in the field. for language there is no right way and cannot be looked at that way. it hurts the generation working and the next generation going into that field by not having equality and allowing these difference to stay. if we do not educate and understand these differences we cannot respect them. AAE is just as important as english but has been looked down upon as if its incorrect.

    2. * (False, 'Recruit') BIPOC students by providing education about and awareness of the fields, starting in elementary school. * (False, 'Retain') BIPOC students in CSD programs by addressing our social-academic partnerships and financial challenges. * (False, 'Represent') BIPOC students by increasing diversity in university faculty and cohort groups.

      the three r's that will bring new diversity into the CSD. it will allow students to feel represented. allow understanding and respect between the diversity and bring us closer together without having to change our voice or language. its equality to allow them to learn the same as Majority students.

    3. It’s inspiring how we persevere through these struggles and journey on to become an SLP or audiologist despite them. But my conversations with colleagues indicate that truly drawing more BIPOC students into the professions requires targeting the three “R”s: recruit, retain, and represent.

      We need to represent, understand and respect these differences. It will allow diversity in language, it will allow different educational standpoints. It will allow diverse SLPs to teach others and help them understand as well. We need language, dialectical, and educational diversity. we are setting these students up for failure in writing, language, and social-academic situations and educational areas.

    4. A Black audiologist, who was born deaf, had received services since infancy, but didn’t meet their first Black audiologist until high school—an experience that led them to the field of audiology. Perhaps an undecided undergraduate student might search the department faculty demographics, see the lack of diversity, and decide not to pursue the major, the graduate program, or the career.

      the differences in demography scares students. you feel alienated if you are the only person of color in your field. Especially if that field is misdiagnosing students with dialects as disorders.

    5. Many BIPOC professionals pointed to difficulties posed by low numbers of faculty of color in their programs. Role models who look like you allow you to picture yourself in that space or doing that thing. In my program, seeing my speech-language pathology professor as “Dr. Black Woman SLP” helped me to see myself following the same path. I was lucky to land her as my mentor because—as I found out later once enrolled—she was the only Black faculty member in the department. My White cohort-mates, however, had a variety of examples to emulate.

      Yes you need role models of color. for you to feel close or similar to the ones teaching you. this doesn't have to be the case if everyone was taught and educated about the differences. It can make students see themselves in the field and allow them to train and educate even more knowing the other side.

    6. BIPOC colleagues on social media reported similar experiences. An SLP who identified as Black and Hispanic struggled to find their “group of people” and never felt like they “truly fit in” being only one of three people of color in their cohort. One Black SLP felt alienated from fellow students’ study groups as everyone else worked together to succeed, and a former speech-language pathology graduate student left their program because of a difficult social experience. This social and academic exclusion seems to take place in graduate school, when students have already committed to a CSD career.

      This is just students who chose Communications Sciences and Disorders, now the ones who are uneducated in it don't learn enough or at all move into fields they may fit in more and understand more. if there was more education earlier about CSD you may want to study and move into that field after highschool instead of learning about seperate sources.

    7. My next theory was that our graduate school experiences may turn us away. People tend to gravitate toward those who look like them or have a perceived commonality. As the only Black student in my graduate school cohort, I didn’t look like anyone else and probably was assumed not to have much in common with other students. After not being invited to participate in study groups and outings, I took the initiative to invite myself to social events with fellow students and to form academic partnerships with them, which was exhausting.

      her view in graduate school that she was discriminated against. She had to force herself to fit in just because she looked different. Even those theres a clear commonality in the things they were learning they were pushed away from participating in study groups and outings. Now if these students were to learn about the differences earlier there understanding and thus respect may change.

    8. Lack of awareness could be one reason BIPOC students are not drawn to CSD—we simply do not know about the field. But in my Facebook conversations with BIPOC and White CSD professionals, I found no discrepancy between the two groups related to when they learned about the fields (in eleamentary/middle school, high school, or college/adulthood). Most learned about the field as older adolescents, perhaps suggesting that the professions need more outreach to younger students.

      Students are not taught early enough about dialects and language differences. we need to allow students to learn and becoming intised by the differences. not taught they are wrong. everything in grade school teaches you to speak, write, and learn one way. once you go into the field it seems like grammar and dialect difference is wrong. it causes another student forced into Standard American English when they dont need to change.

    1. Why would users want to be able to make bots?

      This is actually relevant for a platform I use a lot- Twitter. A while back, monetization was introduced for users that received a lot of engagement. This created a clear financial incentive to create bot-accounts as they could potentially generate revenue for their owner- and as much the number of bots noticeably shot up after this change.

    1. of purpose, his decisions can workagainst each other so that his writinglacks consis

      Having a question gives the writer a better sense of purpose and guide to strive for. Its like there is an end goal to meet therefore it easier to maintain a consistent drive to the goal.

    2. Most of your problems will come fromyour failure to realize that a statementthat seems clear to you may not beclear to them because they cannotalways see from the words alone justwhat you have in mind

      I personally believe that if the reader is able to understand what the writer is talking about, it shows mindfulness from the writers part in sense that he is able to keep in mind his or her reader(s) in mind while in the process of writing their work.

    3. . Writing is not good or bad in itself, but as it succeeds or fails in gettingthe response intended

      No writing is bad. If the writing relating to any matter is well put together even when the information is extremely debatable, it can go very far when it comes to its credibility.

    1. 7:51 the quote by Matt Gaetz "Robots should not be subject to free speech" made the crowd laugh. Its funny because it has become a serious topic to the point where they have had to make laws restricting AI. On the other hand the crowd laughs because this man is stating the obvious. Why would the robot even have a freedom of speech if it docent have real human emotions? I believe they are trying to pass these types of laws to be able to control AI and what it can produce as it could be robbing the government.

    2. at 4:49 Dustin Ballard ask a good question of "to a listener, does it always matter?" when referring to if music should be expressional or just cords. He makes a good point to the audience, would they really like a song enough to see how it was made and the passion behind it? most people wouldn't so what would it matter if AI made it or if an artist stayed up nights on end to create it. He then compares certian circumstances to AI to really show how though we might not use AI for music we do use other things and its not much different such as the example he has mentioned, "used AI to help with some song lyrics? is that much different than a rhyming dictionary"

    1. Away with us he's going,

      sadly, this seems to mark the moment the enchantment has succeeded. This statement suggest the child was actually taken by the faeries.

    2. And whispering in their ears

      Secrecy here is very telling. The faeries "whisper" in their ears which suggests that the ritual of enchantment was still ongoing. Also their whisper highlights the faeries deceptive intentions because if their intentions were benevolent then there was no need for whispering

    3. With a faery, hand in hand,

      The image of the child going hand and hand with the faery shows the pattern throughout the poem. First the luring, then the ritual followed by the distraction of bubbles and finally physical contact. Hand and hand is the moment of capture.

    4. And chase the frothy bubbles, While the world is full of troubles

      The image of chasing "frothy bubbles" while the world is full of troubles suggests that the feary world is an elaborate distraction so while the world is full of troubles the faery will be luring children with bubbles.

    5. Mingling hands and mingling glances

      I found this part kind of creepy. The repetition of the word "mingling" in "mingling in hands and mingling glances" suggests a spell is taking place. The joining of hand and the exchange of glances working together to complete the spell and lure the child.