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   Sequence analysis allows functional annotation of tyrosine recombinases in prokaryotic genomes

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   Subepidermal blisters are healed by wedge-shaped keratinocytes of hair follicle origin

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   Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

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   http://biorxiv.org/cgi/content/short/2020.08.10.243220

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   Somatic transposition in the Drosophila intestine occurs in active chromatin and is associated with tumor suppressor gene inactivation

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   REPRESSION BY HDAC3 AND DAX1 MEDIATES LINEAGE RESTRICTION OF EMBRYONIC STEM CELLS

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   Gametic specialization of centromeric histone paralogs in Drosophila virilis

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    On the Relation of Gene Essentiality to Intron Structure: A Computational and Deep Learning Approach

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    Spurious regulatory connections dictate the expression-fitness landscape of translation factors

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    hu.MAP 2.0: Integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies

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    http://biorxiv.org/cgi/content/short/2020.10.21.348854

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    Multidimensional Chromatin Regulation of Cell Lineage Differentiation in a Metazoan Embryo

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    CODEX, a neural network approach to explore signaling dynamics landscapes

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    Mapping the micro-proteome of the nuclear lamina and lamin associated domains

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    Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments

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    Combinatorial action of transcription factors in open chromatin contributes to early cellular heterogeneity and organizer mesendoderm specification.

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    Carbonic anhydrase VII regulates dendritic spine morphology and density via actin filament bundling

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20. Apr 2021
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    CDCP1 controls compensatory renal growth by integrating Src and Met signaling

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    Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2

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    https://doi.org/10.1101/2020.06.12.149229

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    Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and -deficient cells

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    Transneuronal interactions facilitate axonal compartment formation

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    CASB: A concanavalin A-based sample barcoding strategy for single-cell sequencing

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    An ATM-MYBL2-CDC7 axis regulates replication initiation and prevents replication stress in pluripotent stem cells

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    Urinary proteome profiling for stratifying patients with familial Parkinsons disease

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    The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes

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    Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors

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    Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

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    CellMixS: quantifying and visualizing batch effects in single cell RNA-seq data

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    Malaria parasites differentially sense environmental elasticity during transmission

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    Cryo-EM reveals the complex architecture of dynactin's shoulder and pointed end

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    NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development

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    Glial Hedgehog and lipid metabolism regulate neural stem cell proliferation in Drosophila

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    Phosphoproteomics Reveals a Distinct Mode of Mec1/ATR Signaling in Response to DNA End Hyper-Resection

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    ALIX and ceramide differentially control polarized exosome release from epithelial cells

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    Antioxidant nanozyme counteracts HIV-1 by modulating intracellular redox potential

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    Integrated intra- and intercellular signaling knowledge for multicelullar omics analysis

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    Identifying Modules of Cooperating Cancer Drivers

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    Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate Plk1

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    Htr6 and Sstr3 ciliary targeting relies on both IC3 loops and C-terminal tails

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    IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

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    Helicobacter pylori accelerates KRAS-dependent gastric dysplasia

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    SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis

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    Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism

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    Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

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    Overlapping oriC and centromere-like functions in secondary genome replicons determine their maintenance independent of chromosome I in Deinococcus radiodurans

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    Short duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy

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    The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity

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    Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast

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    A double role of the Gal80 N-terminus in activation of transcription by Gal4p

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    Altered hematopoietic system and self-tolerance in Bardet-Biedl Syndrome

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    CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

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    Selective cross-linking of coinciding protein assemblies by in-gel cross-linking mass-spectrometry

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    http://biorxiv.org/cgi/content/short/2020.08.11.246678

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    In-depth and 3-Dimensional Exploration of the Budding Yeast Phosphoproteome

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    Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling

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     Epigenetic gene-expression links heart failure to memory impairment

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     Biogenic Amine Neurotransmitters Promote Eicosanoid Production And Protein Homeostasis

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     A multifaceted cellular damage repair and prevention pathway promotes high level tolerance to β-lactam antibiotics

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     Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites

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     Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease

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     Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

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     Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development

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     Nucleo-plastidic PAP8/pTAC6 couples chloroplast formation with photomorphogenesis

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     Actin filament oxidation by MICAL1 suppresses protections from cofilin-induced disassembly

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     Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.

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     Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration

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     MicroRNA-574 Regulates FAM210A Expression and Influences Pathological Cardiac Remodeling

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     Modulation of Yorkie activity by alternative splicing is required for developmental stability

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     Structural inventory of native ribosomal ABCE1-43S pre-initiation complexes

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     Translation is required for miRNA-dependent decay of endogenous transcripts.

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     Translational adaptation to heat stress is mediated by 5-methylcytosine RNA modification in Caenorhabditis elegans

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     Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages

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     AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170

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     https://doi.org/10.1101/2020.06.18.160614

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     Post-mitotic expansion of cell nuclei requires ACTN4-mediated nuclear actin filament bundling

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     ALX1-related Frontonasal Dysplasia Results From Defective Neural Crest Cell Development and Migration

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     Single-cell analysis uncovers latent heterogeneity in zebrafish thyroid follicular cells

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     Alternative splicing coupled nonsense-mediated decay shapes the temperature-dependent transcriptome

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     The tRNA pseudouridine synthase TruB1 regulates the maturation and function of let-7 miRNA

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     Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

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     Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA Repair

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     Predictive features of gene expression variation reveal a mechanistic link between expression variation and differential expression

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     Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm

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     The architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography

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     Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer

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     TIP5 safeguards genome architecture of ground-state pluripotent stem cells

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     A single-cell transcriptome atlas of the adult muscle precursors uncovers early events in fiber-type divergence in Drosophila

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     Non-apoptotic caspase-dependent regulation of enteroblast quiescence in Drosophila

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     Oncogenic mutant RAS activity is rescaled by the ERK/MAPK pathway

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     CEN-tools: An integrative platform to identify the contexts of essential genes

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     Genome-wide off-rates reveal how DNA binding dynamics shape transcription factor function

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     Pseudo-repeats in doublecortin make distinct mechanistic contributions to microtubule regulation

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     https://doi.org/10.1101/2020.07.14.202028

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     LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signaling

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     Myf6/MRF4 is a Myogenic Niche Regulator Required for the Maintenance of the Muscle Stem Cell Pool

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     Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration

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     Prominin-1-Radixin Axis controls hepatic gluconeogenesis by regulating PKA activity

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     Aggregation and Disaggregation Features of the Human Proteome

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     G-Quadruplexes Act as Sequence Dependent Chaperones via Protein Oligomerization

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     The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome

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     DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

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     A meiosis-specific AAA+ assembly reveals repurposing of ORC during budding yeast gametogenesis

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     multicrispr: fast gRNA designer enables prime editing and parallel targeting of thousands of targets

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     Profiles of circulating histidine-rich glycoprotein associate with age and risk of all-cause mortality

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     Peptide-based quorum sensing systems in Paenibacillus polymyxa

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     A time resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth

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     An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella

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     Attenuation of cGAS/STING Activity During Mitosis

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     https://doi.org/10.1101/2020.05.20.106575

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     Cell cycle dynamics of lamina associated DNA

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     Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast

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     Fxr1 regulates sleep and synaptic homeostasis

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     Novel features of centriole polarity and cartwheel stacking revealed by cryo-tomography

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     Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis

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     Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates

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     The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death

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     Stage-specific transcriptomes and DNA methylomes indicate an early and transient loss of transposon control in Arabidopsis shoot stem cells

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     Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA

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     Rab10 Regulates Macropinocytosis in Phagocytes

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     Programmable and portable CRISPR-Cas transcriptional activation in bacteria

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     AGO1x prevents dsRNA-induced interferon signaling to promote breast cancer cell proliferation

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     Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment

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     Molecular mechanism of attenuation of heat shock transcription factor 1 activity

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     State transitions of a developmental oscillator

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     The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

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     Predicting antigen-specificity of single T-cells based on TCR CDR3 regions

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     Protective anti-prion antibodies in human immunoglobulin repertoires

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     PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

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     Mapping of the nucleolar proteome reveals spatiotemporal organization related to intrinsic protein disorder

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     Structural insights into filament recognition by cellular actin markers

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     https://doi.org/10.1101/2020.03.31.016048

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     The protein architecture of the endocytic coat analyzed by FRET

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     Hormonal dysregulation after prolonged HPA axis activation can be explained by changes of adrenal and corticotroph masses

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     Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

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     Nuclear lamin B is crucial to the nuclear envelope integrity and extracellular trap release in neutrophils

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     An unexpected contribution of lincRNA splicing to enhancer function.

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     Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells

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     Lipid-associated PML domains regulate CCTα, Lipin1 and lipid homeostasis

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     Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis

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     A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus

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     Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

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     Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)

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     Using deep mutational scanning data to benchmark computational phenotype predictors and identify pathogenic missense mutations

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     Actin accumulates nesprin-2 at the front of the nucleus during confined cell migration

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     Temporal specificity and heterogeneity of the fly immune cells' transcriptional landscape

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     Cyclin B1 scaffolds MAD1 at the corona to activate the spindle assembly checkpoint

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     Spontaneous and coordinated Ca2+ activity of cochlear sensory and non-sensory cells drives the maturation of OHC afferent innervation

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     Identification and characterization of diverse OTU deubiquitinases in bacteria

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     Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

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     Exploring endocytic compartment morphology with systematic genetics and single cell image analysis

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     STAT3-dependent systems-level analysis reveals PDK4 as an independent predictor of biochemical recurrence in prostate cancer

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     HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

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     Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch

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     Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

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