Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0200006

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0009815

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001947

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001942

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001763

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001763

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001382

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001382

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002415

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000175

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002705

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002705

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002705

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000369

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000369

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000369

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000325

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000322

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0005280

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000316

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000348

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000348

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000348

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000348

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002003

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002003

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000256

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000256

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000256

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000717

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000717

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000736

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000736

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0007018

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0007018

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001265

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000639

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000540

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000505

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000407

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001250

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001249

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001249

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001249

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001249

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001270

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001270

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001270

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001270

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001270

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001270

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000750

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000750

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000750

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000750

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000750

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001263

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001263

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001263

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001263

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001263

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001263

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692266/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692269/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692269/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692266/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692268/

allele id lookup result: http://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_caid?caid=CA8805224

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003251

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692266/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692266/

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001290

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001290

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002093

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003517

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001744

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0004719

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001659

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003170

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003170

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000926

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001395

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001397

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001397

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0004322

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/547946/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692227/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/547947/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/547947/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/599396/

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/692228/

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0006268

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0004322

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003235

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001762

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0006579

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001508

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002487

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000639

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000565

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002181

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0025330

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0100703

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0008936

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001257

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002300

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003470

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002353

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002069

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001250

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001251

Monarch lookup result: https://monarchinitiative.org/phenotype/HP%3A0003202

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003323

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000750

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001249

Monarch lookup result: https://monarchinitiative.org/phenotype/HP%3A0100293

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0100295

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002206

Monarch lookup result: https://monarchinitiative.org/phenotype/HP%3A0100293

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003798

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003554

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0040288

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001283

Monarch lookup result: https://monarchinitiative.org/phenotype/HP%3A0004887

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002747

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002943

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002943

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0008780

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0005879

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0006380

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000218

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001252

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0009028

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0030319

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001838

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001776

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0010557

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001845

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001561

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0003355

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0010899

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0008770

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000787

variant id lookup result: https://www.ncbi.nlm.nih.gov/clinvar/variation/559601/

allele id lookup result: https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_caid?caid=CA346813374

allele id lookup result: https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_caid?caid=CA346764646

allele id lookup result

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001250

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0031936

variant id lookup result

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0002019

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0004780

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000486

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001388

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001212

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000316

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000527

Monarch lookup result: https://monarchinitiative.org/phenotype/HP%3A0000520

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000337

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000325

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000718

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000817

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0012760

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0000729

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001290

Monarch lookup result: https://monarchinitiative.org/phenotype/HP%3A0011344

Monarch lookup result: https://monarchinitiative.org/phenotype/HP:0001344

Monarch lookup result: https://monarchinitiative.org/phenotype/HP%3A0000002

CaseI1-2: Case I1 is the asymptomatic paternal grandfather of proband 2 in family 2. The heterozygous Thr295Ile substitution was found in this individual.

CasePresentingHPOs: HP:0005543, (Reduced protein C activity)

HPOsFreeText: Protein C activity was reduced: Normal range = 70-140% (actual = 39%). Patient also had reduced protein C antigen: Normal range = 70-130% (Actual=36%).

CaseNotHPOs:

NotHPOsFreeText:

CaseAddInfo: This individual was asymptomatic.

CasePMIDs:

CaseI3-2: Case I3 is the asymptomatic grandmother of proband 2 in family 2. The heterozygous Leu-34Pro substitution was found in this individual.

CasePresentingHPOs: HP:0005543, (Reduced protein C activity)

HPOsFreeText: Protein C activity was reduced: Normal range = 70-140% (actual = 48%). Patient also had reduced protein C antigen: Normal range = 70-130% (Actual=36%).

CaseNotHPOs:

NotHPOsFreeText:

CaseAddInfo: This individual was asymptomatic.

CasePMIDs:

CaseII4-2: Case II4 is the asymptomatic mother of proband 2 in family 2. The heterozygous Leu-34Pro substitution was found in this individual.

CasePresentingHPOs: HP:0005543, (Reduced protein C activity)

HPOsFreeText: Protein C activity was reduced: Normal range = 70-140% (actual = 55%). Patient also had reduced protein C antigen: Normal range = 70-130% (Actual=34%).

CaseNotHPOs:

NotHPOsFreeText:

CaseAddInfo: This individual was asymptomatic.

CasePMIDs:

CaseII2-2: Case II2 is the asymptomatic paternal uncle of proband 2 in family 2. The Thr295Ile substitution was found in this individual.

CasePresentingHPOs: HP:0005543, (Reduced protein C activity)

HPOsFreeText: Protein C activity was reduced: Normal range = 70-140% (actual = 44%). Patient also had reduced protein C antigen: Normal range = 70-130% (Actual=33%).

CaseNotHPOs:

NotHPOsFreeText:

CaseAddInfo: This individual was completely asymptomatic.

CasePMIDs:

CaseII3-2: Case II3 is the clinically asymptomatic father of proband 2 in family 2. The Thr295Ile substitution was found in this individual.

CasePresentingHPOs: HP:0005543, (Reduced protein C activity)

HPOsFreeText: Protein C activity was reduced: Normal range = 70-140% (actual = 43%). Patient also had reduced protein C antigen: Normal range = 70-130% (Actual=34%).

CaseNotHPOs:

NotHPOsFreeText:

CaseAddInfo: This individual was completely asymptomatic.

CasePMIDs:

CaseIII1-2: Proband 2 (Case III 1 family 2) was a 19 year old male diagnosed with deep vein thrombosis in both legs since the age of 16. The family of this individual was asymptomatic with respect to thrombolytic disease and was non-consanguineous.

CasePresentingHPOs: HP:0002625, HP:0005543, HP:0004936, (Deep venous thrombosis), (Protein C deficiency), (Venous thrombosis),

HPOsFreeText: Deep vein thrombosis was in both legs since age of 16. This patient also had low protein C antigen.

CaseNotHPOs:

NotHPOsFreeText:

CaseAddInfo: This Case (Case III1-2) was designated as Proband 2.

CasePMIDs:

CaseI1-1: Case I1-1 is a 54 year-old male from Family 1. This individual has a heterozygous Asp255His mutation and is the father of the proband (II1-1). This individual was asymptomatic and lab results were within normal ranges.

CasePresentingHPOs:

HPOsFreeText:

CaseNotHPOs:

NotHPOsFreeText: Patient was completely asymptomatic.

CaseAddInfo:

CasePMIDs:

Is this in terms of the individual or a communal/societal sense? Or both? I took it to mean both on the individual and societal levels, but I want to make sure I am interpreting this correctly.

I believe people in sometimes feel they have no voice are say. There are pathways were people try there best to find change and still see no result i believe to have to change we have to write congress men and people in the government letters to how we may feel. We must be aware together but, its better sometimes to be the odd person out the bunch. It takes one person doing something different to see results.

It would be very interesting to discuss this and the surrounding passages in light of the armed standoff that occurred in either Oregon or Washington about a year ago regarding the use of federal lands for grazing purposes by the local ranchers.

I like this piece of the document because I think it is extremely important that students today take the time to reflect and decompress. Stepping away from the grind of everyday school work periodically is essential for one's success. Many forget to practice the things they genuinely like to do in conjunction with the necessary practice of their studies. One must live, experience, and reflect back on these experiences in order to truly learn and develop their knowledge set over time. It is saddening to see hobbies and talents diminish in ones college years simply because they think there is not enough time for these non-academical activities. Self care is essential and doing the things one truly loves is a key component to practicing self care. This is something that has slowly diminished in the modernity of society and the its presence in the document shows that it is an important component of life and one's success. Additionally, it is one part of the document that is undeniably true or at least logical which in itself is worth noting.

In this annotation, though I understand there is a contradictory aspect of this statement, (given UVa's history of gender and racial exclusion) that’s not where I’d like to focus. Rather, I ask, existentially, are there harms to societal freedom? Currently, our society values the idea of being an individual more and more. According to the famous sociologist Peter L. Berger, modern society's concept of dignity is reliant on an individual emancipating himself from certain societal rules. Our society's thirst for uniqueness can be seen as harmful. Later in the report, Jefferson writes about how molding individuals into habits of reflection will “render them examples of virtue to others & of happiness within themselves.” But, now I ask, is our modern day search for “dignity” getting in the way of what other’s consider virtuous? Increasingly people feel loneliness and estrangement from themselves and society. Can there be too much freedom?

This is an interesting quote as it made me question how education generates habits of application? Is this implying that students of the University of Virginia will provide structure for future generations? “Habits of application” connotes that students will become ambitious, rather than waiting around for change, they will implement it themself. This task can often seem impossibly challenging in today’s times, however it is interesting to see how UVA’s mission was to generate powerful students since it’s creation. The “order and love of virtue” mentioned in this quote shows that education must be driven by passion. Jefferson’s entire perspective of his University was for it to be a center for lifelong learners as education should not have a limit. To lack passion is to be ignorant as there is no point to be informed without any desire or intent supporting it. Another question I had was whether the “moral organization” of society is pointing to the idea/conclusion that everyone should think in the same way? It is important to have a wide range of varying opinions; changes within societal culture and norms do not change without this element. How can there be “habits of application” if everyone is under one “moral organization”? This statement seems to contradict itself as they are developing students who will potentially change and challenge the moral organization of our society. Perhaps this was the point all along. My Doing Fieldwork engagement has taught me to look at each person as their own system, so it is interesting to see how each of our individual systems are supposed to conform to a single ideal and organization within our American society (not even considering all of the standards from the rest of the world).

This phrase reflects Thomas Jefferson's vision for the manner in which the University would educate its students. He believed that the value of higher education was that it allowed the individual to reflect on their personal vices, prejudices, and perspectives to strive for personal improvement. Similarly, In his novel, The Myth of Individualism, Peter Callero writes, "Our educational institutions from grade school to college are structured to enhance individual achievement in a competitive system of evaluation." In this way, Callero reveals Jefferson's motivation for an individualistic student, and subsequently an individualistic society. This notion is the foundation for a contemporary, highly individualistic society.

I found this quote interesting because it refers only to white men and how they can attain virtue and social worth from education but people of other races and backgrounds cannot. This reminds me of an article that I read in my engagement class about affirmative action because the minorities were pushing for equal treatment and the opportunity to learn and receive the benefits that education would give them. The author of the article, Richard Rodriguez, was not underprivileged as a kid because he could afford education, so he did not identify with the rest of the minorities because he claimed that have the opportunity to receive an education automatically makes you not a minority. His claim relates to this quote because he sees education as a privilege that brings you up in the world because it gives you virtue and many benefits. In the modern society, people of all races and backgrounds can reap the benefits of education and knowledge, not just white men, and they are able to pass on their knowledge to future generations. It is interesting to see how far society has come in who can receive education and what education can do for everyone in the world.