【方法】模型未纳入数据中心建设带来的总需求效应，这是一个重要的方法论缺陷，因为数据中心建设本身将创造大量就业和经济活动，可能显著影响AI经济影响的总体评估。

Study: Functional study

Model: HEK293 cell lines

Variant: VWF NM_000552.5: c.7664C>G, p.(Pro2555Arg), described as GOF mutation

rare missense variant, MAF = 0.00007

RefSNP_ID:rs915754316

Not reported in ClinVar

Cells lines were transfected and expressed one of the following: wtVWF, p.Pro2555Arg, both variants, or a negative control variant p.Asp2509Glu

Main result:

p.Pro2555Arg is the first VWF GOF variant that increases platelet aggregate size (AS), which is shear-dependent and independent of fibrinogen (fb). May provide a novel risk factor for thromboembolic disease.

Additional results:

Variant does not affect the binding affinity of the C4 domain for BPIIb/IIIa

VWF stem region mutations can enhance VWF's prothrombotic properties

C4 domain of VWF may be a novel antithrombotic drug target.

Keshmirian, A., Bahrami, B., & Deroy, O. (2021, April 27). Many Heads Are More Utilitarian Than One. https://doi.org/10.31234/osf.io/7e3dc

IZA – Institute of Labor Economics. ‘COVID-19 and the Labor Market’. Accessed 6 October 2020. https://covid-19.iza.org/publications/dp13643/.

using aggregate t or chi^2 statistic to test if a set of genes is on aggregate differentially expressed