68045

Bloomington

if you could correct this Gene would we have the future reassured and we can then avoid all of these diseases I very much doubt it and I think it's very dangerous 00:23:49 because

In just a decade, CRISPR has become one of the most celebrated inventions in modern biology. It is swiftly changing how medical researchers study diseases: Cancer biologists are using the method to discover hidden vulnerabilities of tumor cells. Doctors are using CRISPR to edit genes that cause hereditary diseases.

Cas3 systems raises the possibility of its development as a tool for large genomic deletions, such as the targeted removal of entire genes, gene clusters, islands, prophages or plasmids

assay based on engineered selectable CRISPR-spacer integration reporter plasmids

Additional file 1: Table S1

stimulates spacer acquisition from double-strand breaks. This activity is limited by chi sites

sequence motifs that slow RecBCD activity

ethical ramifications of widely accessible tools for altering genomes.

Some worry that this is the first step toward using gene editing to create people with extreme intelligence, beauty or athletic ability. But that, for now, is not possible. Such traits are thought to be affected by possibly hundreds of genes acting in concert, and affected in turn by the environment. The biggest ethical concerns for now are with rogue scientists enticing couples who do not realize the risks to babies that might result from the experiments. And when those children grow up, the altered genes will be passed on to their children, and to their children’s children, for generations to come

The MGEs are less abundant in archaea and bacteria, conceivably due to the intense purifying selection that constrains the spread of selfish elements but nevertheless constitute up to 30% of some bacterial genomes ( Casjens 2003 ; Carle et al. 2010 ).

Systematic discovery of antiphage defense systems in the microbial pangenome

CRISPR screening has emerged as a powerful method for identifying critical functional dependencies in vitro (Koike-Yusa et al., 2014xGenome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Koike-Yusa, H., Li, Y., Tan, E.-P., Velasco-Herrera, Mdel.C., and Yusa, K. Nat. Biotechnol. 2014; 32: 267–273Crossref | PubMed | Scopus (285)See all References, Shalem et al., 2014xGenome-scale CRISPR-Cas9 knockout screening in human cells. Shalem, O., Sanjana, N.E., Hartenian, E., Shi, X., Scott, D.A., Mikkelson, T., Heckl, D., Ebert, B.L., Root, D.E., Doench, J.G., and Zhang, F. Science. 2014; 343: 84–87Crossref | PubMed | Scopus (936)See all References)

Where should we draw the ethical and moral lines? Will CRISPR mean people are making designer babies and eliminating genetic diseases, and is that acceptable? We can wipe out whole species, like the mosquitos that carry the malaria parasite. But should we?

The controversial gene editing technique CRISPR could help scientists solve antimicrobial resistance, cure genetic diseases and much more