studies funded by pharmaceutical companies have three or four times the probability of studies notfunded by pharmaceutical companies of showing eectiveness of an intervention

There is a danger in departing from established guidelines: some studies have shown that physicians nd“exceptions to the rule” more often than appropriate,

epistemic gap . . . between the results of clinical research andthe care of individual patients”

“Is my patientsuciently similar to the trial subjects for the results of the trial to apply to her?” The patient might befrailer than the trial patients, and/or much older, or be of a dierent gender, or have signicantcomorbidities, or lack the requisite social support. Part of clinical expertise is having the ability to answerthis question, perhaps drawing on general pathophysiological and psychosocial knowledge as well asknowledge of the particular patient.

This statement is a carefully crafted backtracking from the 1992 original statement of evidence-basedmedicine, which explicitly advocated “de-emphasizing” what it called “unsystematic clinical experience”(Evidence-Based Medicine Working Group 1992). Now the individual clinical expertise of the physician isrecognized, indeed respected, as an important part of the process.

ealist synthesis uses a context-sensitive mechanistic account of the intervention tosupplement traditional evidence-based reviews

patient variability (age, sex, severity of disease, riskfactors, comorbidities, ethnicity, socioeconomic status), treatment variability (dose, timing ofadministration, duration of therapy, other medications taken), and setting (quality of care). In order toaddress these issues, knowledge of their importance in particular cases is needed.

standardize the evaluation of randomized controlled trials,

What happens to the process of systematic review if we allow the evidence hierarchy to be more nuanced?One consequence is that we may not be able to do a systematic review at all, because of the diculty ofdevising a nuanced and also impartial hierarchy of evidence. There is a shaky line between contextual andbiased determinations. The danger is that departure from a rigid standard “for good reasons” may open thedoor to any number of rationalized (rather than “rational”) departures from that standard. We may lose theactual and/or the perceived object-ivity of systematic review, both of which are necessary. We may also losethe perceived analytic rigor of systematic review, which contributes to its perceived objectivity

the likelihood of bias isdetermined by both trial methodology and the particular study details

Usage - self hosting

Usage - running locally to log in to another instance

What responsibilities do you think social media platforms should have in what their recommendation algorithms recommend?

What experiences do you have of social media sites making particularly bad recommendations for you?

What people near you have been liking, interacting with, or hovering over (they can find your approximate location, like your city, from your internet IP address, and they may know even more precisely)

Interest groups may also form to represent companies, corporate organizations, and governments. These groups do not have individual members but rather are offshoots of corporate or governmental entities with a compelling interest to be represented in front of one or more branches of government.

It is important to note that once the largest value in the list is part of a pair, it will continually be moved along until the pass is complete.

It compares adjacent items and exchanges those that are out of order

it may be a choice between two evils.

features not available in Threads currently include DMs, language translation, the ability to edit posts and the ability to easily switch among multiple accounts.

No ability to search posts:

That may give users pause about adopting Threads.

“the priority is the mobile apps, but we are working on” the web version.

Threads could be set to see only followed accounts, said it’s “on the list” for future enhancements.

Out of the gate, this seemed to be the biggest issue users called out.

other Twitter wannabe

It’s obviously early days.

That sounds like a big number, but it represents less than 1.5% of Instagram’s 2 billion-plus monthly active users.

which looks quite a lot like a clone of Twitter?

5 Ways Instagram’s New App Comes Up Short

So we shouldn’t be surprised when an illegal bookmaker utilizes credit to attract a high-value customer, especially when that customer has shown they are good for it.”

Apr 1, 2024

By Andy McCullough

Inside the ‘very predatory’ world of illegal betting that lured Shohei Ohtani’s interpreter

Meta has been inviting major celebrities to join an early version of the app. Already, big names like Malala Yousafzai, Shakira, and Gordon Ramsay have used it, Meta confirmed.

For Threads to get that same effect, it will need those culture starters who can make compelling short, 500-character posts.

underlying trust in its parent company, which has faced controversy about how it handles user data since the Cambridge Analytica scandal of 2018.

Threads posts be visible on other apps like Mastodon or Wordpress, or vice versa, and have users comment on posts across the apps. And if you decided to stop using Threads altogether, you would hypothetically be able to port all your content over into a new app.

Many users have complained about Twitter’s “For You” feed showing them too much content from random users they don’t want to see, and that they miss the old-school default-chronological feed on Twitter.

which you can now pay for

This is one of Threads’ biggest advantages over other Twitter replacement apps: Over 2 billion people already have a built-in social network on Instagram, so unlike with, say, Mastodon, you don’t have to completely recreate your follower base from scratch.

sn’t ready yet, according to Meta

a very different approach than Twitter, which has been limiting free API access to third-party developers.

Twitter gives you the option to toggle between an algorithmic and chronological-based feed of only people you follow

with some minor differences

int

Meta announced last fall that Instagram had surpassed 2 billion monthly active users

The launch of Threads comes as Musk’s Twitter has faced technical struggles of late.

That said, it’s not clear how many Instagrammers will flock to Threads,

Right now, the app doesn’t include a direct-messaging feature.

By launching Threads through Instagram, the new app has a leg up on other would-be Twitter alternatives.

its frontal attack on Twitter

Sports betting has exploded in the United States in a way that I’m not sure everyone appreciates. It’s now legal in 38 states compared to just one (Nevada) in 2017. A 2018 Supreme Court ruling set the stage for other states to dive into gambling, and they’ve done just that. close dialogAdvertisementclose dialog/* effects for .bx-campaign-1064080 *//* custom css .bx-campaign-1064080 */@-ms-keyframes bx-anim-1064080-spin { from { -ms-transform: rotate(0deg); } to { -ms-transform: rotate(360deg); } } @-moz-keyframes bx-anim-1064080-spin { from { -moz-transform: rotate(0deg); } to { -moz-transform: rotate(360deg); } } @-webkit-keyframes bx-anim-1064080-spin { from { -webkit-transform: rotate(0deg); } to { -webkit-transform: rotate(360deg); } } @keyframes bx-anim-1064080-spin { from { transform: rotate(0deg); } to { transform: rotate(360deg); } } /* rendered styles .bx-campaign-1064080 */.bxc.bx-campaign-1064080.bx-active-step-1 .bx-creative> *:first-child {padding: 0;width: auto;}.bxc.bx-campaign-1064080.bx-active-step-1 .bx-creative {background-color: transparent;}.bxc.bx-campaign-1064080.bx-active-step-1 .bx-close {stroke: transparent;background-color: transparent;border-style: none;border-color: white;border-width: 1px;box-shadow: 0px 0px 0px 3px black;}.bxc.bx-campaign-1064080 .bx-group-1064080-3RBnJGC {position: absolute;top: 50%;left: 50%;transform: translate(-50%, -50%);z-index: -1;}.bxc.bx-campaign-1064080 .bx-element-1064080-wryzWV5 {width: 55px;}.bxc.bx-campaign-1064080 .bx-element-1064080-wryzWV5> *:first-child {animation-name: bx-anim-1064080-spin;animation-duration: 800ms;animation-iteration-count: infinite;animation-timing-function: linear;}.bxc.bx-campaign-1064080 .bx-group-1064080-lyDBLV9 {width: 900px;height: 600px;}.bxc.bx-campaign-1064080 .bx-group-1064080-me4p1bl {padding: 10px;}.bxc.bx-campaign-1064080 .bx-element-1064080-ZdLO37u {width: auto;}.bxc.bx-campaign-1064080 .bx-element-1064080-ZdLO37u> *:first-child {padding: 2px 4px;font-size: 10px;color: rgb(255, 255, 255);text-transform: uppercase;background-color: rgb(0, 0, 0);background-color: rgba(0, 0, 0, 0.34);}#bx-campaign-1064080 .bx-slab { margin-bottom: 32px; } In 2023, Americans gambled a record $119.84 billion on sports, according to the American Gaming Association’s Commercial Gaming Revenue Tracker. In 2017, just $4.8 billion of legal sports betting occurred in Nevada sportsbooks – a 2,397% increase in six years.

Ohtani is the type of player who transcends the sport and counteracts the downward trend in baseball’s national appeal more than anyone else. He is baseball’s biggest star.

Beyond whether there is more to this story than what the facts currently suggest, we’re talking about something that has worried me for years: athletes and any connection to gambling. This is especially the case for baseball and its dark history with betting.

Shohei Ohtani has made his much-anticipated Dodgers debut, but much of the focus is on a story away from the baseball field.

Published 9:56 AM EDT, Fri March 29, 2024

by Harry Enten, CNN

Why the Shohei Ohtani story is so concerning for baseball and sports

Times staff writers Dylan Hernández, Jack Harris and Gustavo Arellano contributed to this report

The IRS and Homeland Security are investigating the Bowyer case for the U.S. attorney’s office in L.A.

The ESPN article stated that the spokesman said the money came from Ohtani to cover Mizuhara’s gambling debts. The interpreter confirmed this account in a lengthy interview with the outlet on March 19, which was arranged by the spokesman, ESPN said.But then the spokesman and later Mizuhara disavowed that account, and it was subsequently replaced with the claim that the interpreter stole the money through wire transfers of $500,000 each, according to ESPN. Brettler’s firm issued a statement saying it had notified law enforcement of the alleged “massive theft.” It has not said which agency it notified.

The league did, however, announce on Friday that it was launching an investigation into Ohtani and Mizuhara.

The first suggested that there was no link, and that Ohtani had no comment in response to a Times query about the Dodger, Bowyer and the investigation, according to a representative for the ballplayer. Next came the version that Ohtani generously paid off the gambling losses Mizuhara owed to Bowyer, ESPN reported after The Times story was published. Then came the current narrative, made public March 20: Mizuhara stole the money. Ohtani said Mizuhara had invented every other rendition of events. In a meeting at their Seoul hotel, Ohtani said, Mizuhara admitted to him the theft and the deception.

Ohtani also said he has “never bet on anything or bet for anyone on a sporting event or asked someone to bet for me.” He also denied knowingly paying Mizuhara’s gambling debts.

Why would any illicit bookmaker allow Mizuhara to accrue a debt in the millions?

He said it would be “highly unlikely” that Ohtani didn’t have a business manager or anyone else in a similar role who could have flagged unusual movements of funds.

the translator would have had to evade all the safeguards typically in place to shield a wealthy celebrity from thievery, fraud and other forms of financial exploitation, experts have told The Times.Those lines of defense would include human and digital protocols for verifying the legitimacy of large withdrawals of money from a bank, in addition to assurances that financial professionals who handle expenses, investments and taxes are performing regular reviews of significant transactions.

That’s because Ohtani’s claims — that his interpreter stole millions of dollars from him to pay a bookmaker and that the ballplayer knew nothing about it — have produced more mystery than clarity, beginning with the unanswered question of how such a large theft could go unnoticed for so long.

The result was a series of shifting accounts of how Ohtani’s name was raised as part of the investigation, with each version presenting him as not being involved in any wrongdoing.

The tip arrived two weeks ago, and it threatened to engulf Major League Baseball’s biggest star, Shohei Ohtani, in scandal. The name of the Los Angeles Dodgers slugger and pitcher had surfaced in a federal investigation of illegal sports gambling — millions of dollars in payments were allegedly made from his bank account to an illicit bookmaker.

March 27, 2024 3 AM PT

By Paul Pringle, Nathan Fenno and Adam Elmahrek

How the saga of Shohei Ohtani and his interpreter unfolded — and why it’s not over

Mizuhara had a contract with the Los Angeles Angels when Ohtani played there and signed with the Dodgers this offseason. Mizuhara confirmed to ESPN he has been paid between $300,000 and $500,000 annually.

Mizuhara and Ohtani are friends in addition to their professional relationship. Mizuhara has interpreted for Ohtani since the star moved to the United States in 2018,

"I want everyone to know Shohei had zero involvement in betting. I want people to know I did not know this was illegal. I learned my lesson the hard way. I will never do sports betting ever again."

"Obviously, he [Ohtani] wasn't happy about it and said he would help me out to make sure I never do this again," Mizuhara said. "He decided to pay it off for me.

A source said Bowyer was aware of the name on the wire transfers but chose not to ask any questions as long as payments came in; however, the source said Bowyer allowed people to believe Ohtani was a client in order to boost business.

"In the course of responding to recent media inquiries, we discovered that Shohei has been the victim of a massive theft

The spokesman presented Mizuhara to ESPN for a 90-minute interview Tuesday night, during which Mizuhara laid out his account in great detail. However, as ESPN prepared to publish the story Wednesday, the spokesman disavowed Mizuhara's account and said Ohtani's lawyers would issue a statement.

The Los Angeles Dodgers interpreter for Shohei Ohtani was fired Wednesday afternoon after questions surrounding at least $4.5 million in wire transfers sent from Ohtani's bank account to a bookmaking operation set off a series of events.

Mar 20, 2024, 05:51 PM ET

Tisha Thompson, ESPN

Dodgers fire Shohei Ohtani's interpreter amid allegation of 'massive theft'

Sometimes you might be tempted to reuse old papers or projects you’ve completed for another class, especially if that work is applicable for your current assignment. However, this type of recycled work could be flagged as plagiarism by plagiarism detection software, and will be unacceptable in many courses

Understand your source

Whenever you use someone else’s ideas, you need to cite them

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User cyber security awareness: Training users about cyber security helps protect against various attacks that target their systems. Documenting and managing assets: We need to know the types of systems and devices that we have to manage and protect properly. Updating and patching systems: Ensuring that computers, servers, and network devices are correctly updated and patched against any known vulnerability (weakness). Setting up preventative security devices: firewall and intrusion prevention systems (IPS) are critical components of preventative security. Firewalls control what network traffic can go inside and what can leave the system or network. IPS blocks any network traffic that matches present rules and attack signatures. Setting up logging and monitoring devices: Without proper logging and monitoring of the network, it won’t be possible to detect malicious activities and intrusions. If a new unauthorized device appears on our network, we should be able to know.

Defensive security is somewhat the opposite of offensive security, as it is concerned with two main tasks: Preventing intrusions from occurring Detecting intrusions when they occur and responding properly

Offensive security focuses on one thing: breaking into systems.

Finally, the pharmacist should assess the appropriateness of all remaining medications.

The second step to evaluate medication appropriateness is to determine whether the patient has a chronic condition but is not receiving an evidence-based medication shown to improve outcomes (ie, potential prescribing omissions, underuse)

Next, certain laboratory test results and vital signs should be examined to monitor the efficacy and toxicity of each medication.

The first step in assessing medication appropriateness is to compare the patient’s medical problem list with his or her drug list.

Similarly, three items from the implicit MAI (lack of indication, lack of efficacy, therapeutic duplication) may also aid in detecting unnecessary drug use.49

will not initially be available

has an extensive history of trying to stamp out social media rivals, partly by copying their features.

is that Instagram wants to make it easier for Threads to operate seamlessly with other platforms

Instagram Notes, where people can share short messages on the site, and a text-focused app using Instagram’s technology.

began its effort to take on Twitter late last year, with dozens of engineers, product managers and designers pitching ideas on what a rival app could look like

“not just because of the ownership, but because of product changes and decisions” that Mr. Musk and others made to how the social platform works.

Mr. Mosseri added, especially at a tumultuous moment in the social media landscape.

As part of that effort, he said, Threads was spun out into a separate app. That way, Instagram would not be too cluttered by trying to make public conversations work inside its existing app.

It does not currently support direct messaging, a feature that Twitter offers. Instagram said it may add features to Threads if new users ask for them.

Threads looks nearly identical to Twitter in many ways.

He later said that Threads achieved 10 million sign-ups within seven hours of its launch.

But Threads has a leg up, backed by Meta’s deep pockets and Instagram’s enormous user base of more than two billion monthly active users around the world.

changed the experience of Twitter by tinkering with its algorithm and other features, and most recently imposed temporary limits

The rollout of Threads ramps up the rivalry between Mr. Zuckerberg and Elon Musk

with some techies referring to it as a “Twitter killer.”

If Instagram executives get their way

Las y los docentes son la clave para crear un entorno de aprendizaje positivo y de apoyo. A menudo son testigos inmediatos de la violencia escolar y los primeros en interceder para detener el comportamiento violento.

It covers a wide range of topics and materials. It has an easy-to-use simple search interface. It can find books and other materials the library provides access to in addition to articles.

Ciberacoso es acoso o intimidación por medio de las tecnologías digitales. Puede ocurrir en las redes sociales, las plataformas de mensajería, las plataformas de juegos y los teléfonos móviles. Es un comportamiento que se repite y que busca atemorizar, enfadar o humillar a otras personas

paywall

They did not age. They did not change. They traveled the world athousand times over. They may be traveling still.Each city is new to them, each shore a strange one. Time has that effecton places, when enough of it has passed. One day they open the gate to agarden in an unfamiliar village. They walk between the orange trees hand inhand. They both think, So, this place is real, never knowing they have bothdreamed this moment.Every night she shuts the windows tight to guard against drafts, and everymorning he dies and is reborn beside her. She reminds his heart to beatagain, as she did so long ago. He kisses her fingers, and combs her hair, andhe treasures her, as only a man who has lost his luck and found it once moreever can.

She breathed in, breathed out, watched the ash gust away from her acrossthe bed, and then his pale body was stretched out beside her once more,made whole as a broken glass had once been made whole

Perhaps he would have said more, but as the first rays of sun shonethrough the window, he burned away to ash. Luzia had known her lovewould destroy him.

“If you are the last thing I see,” he whispered, “it will all have been worthit.”

One of them, a Flemish piratewho had somehow been granted a second life, didn’t question his goodfortune. He pulled the gag from his mouth and, without a word, ran off intothe night.

He was afraid to leave his wife.He was afraid to travel.He was afraid of what news the next letter would bring.When his wife became pregnant, he experienced a dread so vast he hadno way to contain it. Fear was too new to him, too fresh, too limitless.I’ll be different when my child is born, he told himself. But when he sawhis newborn son lying in his cradle, his fear only grew larger. He couldthink of nothing but the perils this world held for anything small orhelpless. He feared drafts. He feared heat. He called doctors and consultedwith astrologers. His holdings dwindled to nothing because he was afraid tomake a choice, lest it be an unlucky one.Eventually his wife left him. “Find me when you’re able. I will wait foryou,” she promised, and went home to her wealthy parents with the baby inher arms.I will go to her, Víctor vowed. Tomorrow.We will journey to the southern city and I will regain my vigor, he toldDonadei. Tomorrow.He died that way, alone in his bed, afraid to leave, afraid to stay, afraid towhisper anything but “tomorrow.”

He couldn’t explain it and yet he felt sure thatsomehow Luzia Cotado was to blame.So he told his patron he was feeling poorly, that he was certain hisabilities would return. Don Víctor had assured him that he knew a wise manwho could restore his talents, who could give him strength and powerbeyond all he’d imagined. They’d have to travel far to see him, but at theend of their journey, beyond the gates of a southern city, they would strike abargain

She hired a new one from the orphanage, who Quiteria taughtto read and write, and who had a great talent with sauces.

The scent of orange blossoms filled her nostrils.

He turned his head and saw Luzia naked on the pyre, her chin heldhigh. She met his eyes and he had the strange sensation that he was liftingup off the pyre. As the smoke filled his lungs, he could swear he smelledorange blossoms

DoñaBeatriz was nowhere to be found. Perhaps she’d gone back to her husband.

Each moment felt too quick, as if he’d already lost his hold on the world.So many years, so much life lived, and he would leave no one to mournhim.

Valentina clutched the sachet of rosemary at her sleeve. For protection.I’m here, she wanted to shout. I’m sorry. I only wanted a little warmth. Ididn’t know what kind of fire I would start

When she wassatisfied with the scene she’d written for the character of the lovesick prisonguard, she went to find Valentina

One evening over glasses of jerez, Valentina had turned to her and said,“Am I not appealing enough to corrupt?”When Quiteria had met Valentina at La Casilla, she had sensed thatbeneath the sour expression and the meager jewels was a woman waitingfor a chance to live. From the first kiss, she was proven right. Valentina hada glutton’s heart and had spent too many years surviving on scraps. Quiteriawas shocked to discover that, after years of infamy and seeking every kindof pleasure, she had finally found a lover who could keep pace with her.

Quiteria Escárcega now that theplaywright had left for Toledo.

In the house across the way, hecould see a woman seated at a harp, her hands moving slowly over thestrings. He sat down and listened and after a time he wept.Across the street the woman at the harp played on, unsure of why she’dchosen to return to the music room that morning when it had been so longsince she’d sought pleasure in it. She didn’t know whom she was playingfor or why she’d chosen such a sad piece. She’d never given much thoughtto the residents of Casa Ordoño, and so she didn’t wonder where the womenhad gone. She played and played, without thought for the way her fingersstung, or for the scullion who had gazed out the window and longed formusic, and who would never hear her song.

Hualit sighed. “At least he died happy. That’s more than most of us canhope for.”Now Hualit was dead too.

One winter Luzia used her wages to buy him a new coat and boots. Shehad saved for months so that she could know he would at least be warmwhen he was out wandering. He’d donned the coat proudly, beaming withpride. He’d done a joyful dance in his new boots and told her that adaughter was a blessing.Two days later, she was walking near the Prado when she saw a group ofpeople gathered by one of the bridges. The cuadrilleros were trying to fish acorpse from the river.She told herself not to look, to go home, that it was none of her concern.But her feet were already carrying her through the crowd. Her father kneltbeneath the bridge, his hands clasped, his face tilted to the sky, exultant. Hewas barefoot and dressed in rags. He’d frozen to death in the night.

“Let me unbraid your hair and I will have no regrets at all.”

Shedrew closer, grateful for his warmth, for the pleasure of leaning into him, aslovers did, as they might never do again.

“Do you want to argue or do you want to kiss me?”He closed the space between them in two strides and took her in his arms.“I assure you I am capable of both.”

He hesitated. “No. But she is already fond of me.”“Fond. That’s nice. It’s good that fond is enough for you.”Rudolfo pressed his face against the grating of the door. “But it is notenough for me!”“Then you must do as I bid, for I die tomorrow.”When she had told him her demands, he said, “Impossible! No, I cannot.”“At least she’s fond of you.”

Butwhen he returned he had the Prince of Olives in tow. Doña Beatriz trailed intheir wake, gowned in golden lace, her hands clasped tightly

It was the same sensation he’d experienced his first nightwith Luzia. As if the sky above had rearranged itself and night would shownew constellations—the shape of a pomegranate, a path through an orangegrove.

Santángel smiled. Their path was chosen. The crossroads long past.

Luzia saw him clearly. She always had. And now he was telling her toattack him, but why? What was his plan?

“Guillén Barcelo Villalbas de Canales y Santángel.”

They were thesacrifice Don Víctor wanted her to offer. Luzia thought of the smell ofcocido, of Valentina unbraiding her hair, of the sprig of rosemary tuckedinto her sleeve, the barest scrap of protection, the barest scrap of kindnessafter years of slaps and punches and disdain.“They prayed as good people do,” Luzia said

Podemos dizerque as atividades ajudam os alunos a colocarem em jogo os seus recursos,as suas estratégias e as suas competências para com isso participarem naconstrução do conhecimento.

there’s no way to quickly verify the accuracy of a Wikipedia article without consulting other sources on the subject.

Although Wikipedia can be a great resource for background information, not all topics have the same amount of depth or coverage.

El acoso escolar o bullying es la exposición que sufre un niño a daños físicos y psicológicos de forma intencionada y reiterada por parte de otro, o de un grupo de ellos, cuando acude al colegio.

Keep in mind that this might be more sources than the minimum you’re required to use.

El bullying o acoso es la agresión para ejercer poder sobre otra persona. Concretamente, los investigadoreslo han definido como una serie de amenazas hostiles, físicas o verbales que se repiten, angustiando a lavíctima y estableciendo un desequilibrio de poder entre ella y su acosador

If you could repeat parts of your life if you could reset what you’ve done, would you? What if that meant something painful. What would you do for a 2nd chance?

If you had more time, would you utilize it to its fullest? Would you waste your days away, or would you make memories? After time has passed, would you still remember those days, or do they not matter to you anymore?

Las comunidades pueden apoyar la creación de un ambiente seguro y acogedor para los niños en las escuelas a través de iniciativas de sensibilización y prevención de la violencia, el acoso y la discriminación.

So then when do I really get a break? If we’re playing the number games here, the numbers aren’t adding up to a whole lot of time for rest and relaxation.

but the future is still the end goal. A destiny set in stone.

He did not say what measures the US was prepared to take.