The inner lining of organs and body cavities such as the stomach.

A thin, clear, acidic fluid secreted by the stomach glands.

The state of being thick and semifluid in consistency.

A deviation from a regular pattern, path, or level of operation.

A twisting force that causes rotation.

Oral subchronic toxicity refers to adverse effects occurring after repeated administration of a test sample.

Involuntary movements of the longitudinal and circular muscles, primarily in the digestive tract but occasionally in other hollow tubes of the body, that occur in progressive wavelike contractions

Acute oral toxicity refers to adverse effects following oral administration of a single dose of a substance.

An object which has only one unstable point of balance.

Any substance or mixture of substances intended to be used in the manufacture of a drug product and that, when used in the production of a drug, becomes a functional ingredient in the drug product

The open space within a tube-shaped body part

An early sample, model, or release of a product built to test a concept or process.

The action of causing a machine or device to operate.

Second most common marine grade stainless steel.

Connections between cells that prevent the passage of molecules and ions through the space between membranes of touching cells

An enzyme (a biological catalyst) which breaks down proteins and peptides

Biodegradable polyester with a low melting point of around 60°C.

The ability of a drug or other substance to be absorbed and used by the body

millimeter scale pillars

Situated or applied under the skin

Plasma is a yellowish liquid component of blood that holds the blood cells of whole blood in suspension. It is the liquid part of the blood that carries cells and proteins throughout the body.

A hormone produced in the pancreas which regulates the amount of sugar in the blood. The lack of insulin causes a form of diabetes.

A simulation software to create accurate models

In a living organism

A hole made by puncturing or piercing

Fluid that aids digestion

A common sugar

A sugar substitute

3D imaging technique using x-rays to see the inside of an object by viewing it slice by slice

The study of the microscopic structures of tissues

Acting independently; the ability to act without instruction

becoming widely spread

Occuring or administered elsewhere in the body other than the mouth

The GI tract is a series of hollow organs that form a long tube from the mouth to the anus. The organs within the tract include the mouth, esophagus, stomach, small intestine, large intestine, and anus.

Biomacromolecules are the building blocks of life. The different macromolecules are: Proteins, Lipids, Carbohydrates, and Nucleic Acids. Each of these macromolecules are responsible for different biological functions within the body and the cells

Thermoset: applying heat to harden or cure the material. This creates the matrix encapsulating the device.

Thanks to the healing ability of the polyimine and the liquid nature of the eutectic LM circuitry, bonds can be reformed and reshaped throughout the device.

Upon thermosetting, dynamic covalent bonds are formed between the atoms that can readily assemble and disassemble. This gives the polyimines their unique healing ability.

An electrocardiogram sensor records the pathway of electrical impulses throughout the heart. This data can be used to monitor the heart's condition and response to physical exertion.

A reaction that converts an -imine compound into smaller monomers/oligomers. The researchers discovered this reaction to be useful for separating the chip components and LM from the matrix by solubilizing the these monomers/oligomers in methanol.

Eutectic: a mixture of substances that melts and solidifies totally at the same temperature, which is lower than the melting points of the individual constituents.

Eutectic LM: A mixture of liquid metals.

A form of light that is slightly above our visible light spectrum. Since it is not within our visible light spectrum, it is invisible to the naked eye, but it still provides useful applications in nature and everyday life such as remote controls for your television.

This is the use of any combination of materials, coloration, or illumination for concealment, either by making animals or objects hard to see, or disguising them as something else.

A group or system that deals with the behavior, manipulation, and precise control of fluids that are constrained to a small scale. This often deals with objects that are measured to be in the tens to hundreds of micrometers.

A set of things working together that uses two or more steps to create a product. This is also chemically created to imitate an existing and natural set.

Materials belonging to this category include things made up by smaller units called monomers. However, this category contains many monomers arranged in a way that keeps the overall object flexible and non rigid.

This is the emission of light from an object that is not a result of heat, but a form of cold-body radiation.

This is the production and emission of light by a living organism.

the process by which bacteria or other microorganisms are unintentionally transferred from one substance or object to another, with harmful effect.

Definición de inflamación

Definición etimológica

Movement of genes from one species into the gene pool of another species by the repeated crossing of a hybrid with one of its parents.

Where a single nucleotide base is changed, which results in a different amino acid.

body copy, body text

A part of Earth’s interior that lies between the dense, extremely hot core and the thin outer layer, known as the crust. It is made up of a thick, rocky shell that constitutes 84% of Earth’s volume. In geologic time, it behaves as a viscous fluid.

Both ocean island basalts and continental plume-related basalts come from deep within the mantle. OIBs intruded into oceanic (basaltic) crust, whereas continental plumes intrude into continental crust (for example, Deccan traps in India).

This is a high-pressure and high-temperature polymorph (version) of quartz.

This is an anatomical term which refers to the front of the body, or near the head.

In the case of planaria, it refers to the head.

This is anatomical term which refers to the back of the body, or near the hind end of the body.

In the case of planaria, it refers to the the hind end.

Janus was a Roman god and doorkeeper to the heavens. Relevant here, Janus was usually depicted with two heads, one facing the past and the other towards the future.

Here, protrusions refer to bulges of cells.

Refers to the outer edge.

A series of linked chemical pathways in which one chemical in the series activates another chemical in the pathway, which ultimately leads to a specific cell function.

Adenomatous polyposis coli, or APC, is gene that plays many roles, including acting as a tumor suppressor. APC has also been found to play a role in cell division and directing cells where to go once division takes place. In order to do its job, APC directs β-catenin in the Wnt signaling pathway.

Read more in the Journal of Cell Science. The PDF is also available in the "Related content" tab.

A mechanism used by both plant and animal cells to silence a gene using a double-stranded DNA molecule. DNA is converted into the smaller RNAi molecules used to turn genes off. Scientists are now able to use this natural process to turn off genes they are studying so they can learn more about their function.

This is an image depicting this common planarian.

A second exposure to the same threat. The immune system is, under certain conditions, able to remember threats it has encountered before and react to them more quickly and effectively upon each subsequent exposure.

White blood cells central to adaptive immunity. T cells are able to recognize when cells are diseased and can kill them so they don't spread throughout the body.

This family of proteins is employed to activate neurons by driving cations (including sodium, calcium, hydrogen, and potassium) into the cell and causing the membrane potential to become more positive, leading to depolarization.

Halorhodopsins and bacteriorhodopsins typically inactivate neurons by driving chloride ions into the cell or hydrogen ions out of the cell and causing the membrane potential to become more negative, leading to hyperpolarization.

A positive ion like hydrogen (H+), sodium (Na+), or potassium (K+).

A tube inserted into the body to facilitate the delivery of fluids or materials to a specific region.

A group of nuclei located at the base of the forebrain that is responsible for motor control and cognition.

Major component of the basal ganglia that targets the substantia nigra.

Opposite the lesion.

A subregion of the midbrain responsible for motor control.

Progressive loss of function of neurons, usually a result of neuron death.

A graphical representation (usually lines through a point on the graph that run parallel to one of the axes) showing the amount of uncertainty there is in the location of that point. All scientific data collection includes uncertainty; error bars allow researchers to show how confident they are in their results. Large error bars mean there is a lot of uncertainty (lower confidence), whereas smaller error bars mean there is less uncertainty.

A statistical term, the Greek letter beta, refers to the probability that you can accept the null hypothesis (which states that values affirmation has no effect) when in fact the null hypothesis is wrong.

The difference in performance (for example, on standardized tests) between minority students and white students.

Any form of an exam that requires all people taking the test to answer the same questions and is scored the same way in all cases, so that comparisons can be made between all people who take the test. These are typically multiple choice tests taken by large populations of students (for example: all 8th grade students in the United States).

Any outside force (real or perceived) that challenges a person's values, beliefs, or sense of self.

Stereotype (or identity) threat is a subset of psychological threat in which a person feels they will be judged according to common prejudices about some aspect of their identity (for example: race, ethnicity, or gender).

An experiment in which neither the participants nor the experimenters know which group each participant is assigned to until after the data are analyzed.

An intervention in which people reflect on and write about the beliefs and values (e.g., family, integrity) that are important in their lives.

Turning a gene off so that it does not go through transcription and translation (gene expression) which prevents the production of its protein product (β-catenin) being made by the cell.

The regulated breakdown of a cell or cellular product, which is used to control gene expression and ultimately cellular function. In this case, the breakdown of APC leads to an increase in β-catenin.

The copying of DNA into mRNA, which is the first step in the process known as gene expression.

Watch this video to learn more about the role of transcription and transcription factors: https://www.hhmi.org/biointeractive/signal-molecules-trigger-transcription-factors

Regeneration in this case, refers to the replacement of lost or damaged tissue.

This video will help you understand the process of tissue regeneration: https://www.hhmi.org/biointeractive/tissue-regeneration-animals

The cells that were supposed to be in the posterior end migrated to the anterior end of the animal, or vice versa.

The chemicals at the beginning of the signaling pathway.

How long the protein lasts as part of the signaling pathway.

The percentage or proportion of individuals with the genotype that present the phenotype. In other words, organisms may have the genes by may not show the trait. You can find more information about these terms in this article: https://www.ncbi.nlm.nih.gov/books/NBK22090/

The ability or tendency of an organism to maintain internal stability. This includes maintaining certain ranges of physiological processes such as temperature, pH, or ions such as calcium.

Genes are used to create both a front and a back for an organism during early embryonic development.

A molecule, such as a protein, than controls gene expression by either turning it on or off.

Specialized protein complexes that allow cells to stick to each other.

Freely swimming flatworms from the taxonomic class Turbellaria that inhabit freshwater.

For most organisms it involves removal of a limb. Planaria do not have limbs, so in this case refers to removing either the front or hind end of the body.

Refers to events that occurred at the same time and are associated with each other.

Members of this group of mammals (which includes humans) carry the developing fetus in the uterus, where the placenta facilitates the exchange of nutrients and wastes between the mother and the fetus.

These turtles are related to modern snapping turtles and have a similar morphology. They had large heads and long tails.

These are floodplain deposits made when the river broke through its natural flood banks. Heavier sediments are deposited closer to the river channel, while lighter sediments, such as sand and silt, are deposited farther away from the channel.

These are single-celled, bottom-dwelling organisms that live on or within the carbonate-rich sediment surface. https://www.biointeractive.org/classroom-resources/foraminiferaearths-microscopic-recordkeepers

https://ucmp.berkeley.edu/fosrec/Wetmore.html

This is one of the two groups angiosperms are traditionally divided into. A number of traits distinguish dicots from the other group, the monocotyledons (monocots). The seeds of dicots contain two embryonic seed leaves; monocot seeds contain one.

This is one of the largest volcanic areas on Earth. Its lava flows cover an area of about 500,000 square kilometers.

This stage of the geologic timescale refers to the North American faunal stage, spanning from 66,000,000 to 63,300,000 years BP (Before Present).

The extinction event that wiped out nearly three-quarters of all plant and animal species on Earth 66 million years ago.

The abbreviation for "kilo annum." It signifies time in thousands of years.

Refers to the study of rock layers that can be understood over a large area.

Learn more about stratigraphic principles with HHMI BioInteractive: https://www.biointeractive.org/classroom-resources/stratigraphic-principles

Means that the species cannot breed to produce fertile offspring because of some barrier. That barrier could be geographic, behavioral, or some other type. A well-known animal that is reproductively isolated is the mule.

The alleles for a certain locus listed according to their dominance, that is, their effect on the phenotype they affect.

This term means that the association of certain alleles at different loci is not random. Essentially, certain alleles of certain genes are often linked together and found in these combinations in the Big Birds.

Occurs when the frequency of alleles in an organism changes due to chance. Genetic drift (sometimes referred to as drift) is strongest in small populations such as the one studied here, because chance (random sampling) strongly affects the alleles present in the population.

As in a bird's beak.

When hybrid offspring show traits that are more extreme than those of the parents. For example, when a hybrid plant offspring is much taller than, or much shorter than, either of the parent plants.

Here, a genetic group of individuals that are all descended from one initial ancestor.

Referring to the formation of a new species when two different species mate to produce a new species.

Definition: A polysaccharide glucan that is medically used to reduce blood viscosity.

For the paper: Dextran perfusion is based on flowing a dextran solution through the tube/pipe to determine whether it is hollow (allows fluid flow), and transports fluids as expected.

A specific type of perfusion (previously defined) that moves through channels based on motion similar to that of heart pumping blood to the body.

Lab testing relating to pigs

A protein that is involved in angiogenesis activation.

Hydrogels loaded with live cells.

For the paper, this is an appealing option that helps engineering potential tissue constructs with biomimetic structure and function. Cell-laden hydrogel is a promising scaffolding system for engineering artificial bone, cartilage, cardiac and neural tissues.

Staining that is a fluorescence assay (as shown in image on Panel E) which shows cell viability, that is whether the cells are dead or live. The live cells emit green light where the dead cells emit red light.

Whose properties can be changed back and forth by increasing or decreasing temperature.

For the article, specific thermoreversible hydrogels form a gel when cooled and return to a viscous fluid state when exposed to heat.

The passage of blood or fluids through blood vessels or other channels in an organ or tissue.

In this paper, perfusion is needed to sustain healthy tissues and organs.

Micro-computed tomography (Micro-CT) is a 3D imaging technique utilizing X-rays to see inside an object, slice by slice. It is similar to a CT scan, but on a micro-scale. Micro-CT provides high resolution 3D imaging of the interior structure of materials and biological samples without having to cut the samples.

cells that are on the inner surface of blood vessels

Leaky heart valves. A condition in which the heart valve doesn't close tightly, which allows blood to flow backward in the heart.

Artificial blood vessel structures through which one can flow fluids which nurture cell growth.

Unobstructed (open inside allowing for fluid flow) and has several outlets to be connected to other tubes/pipes, similar to the arteries and veins in our body.

G-code is a language that humans use to tell a machine how to do something. With 3D printing, g-code contains commands to move parts within the printer.

Micro-computed tomography (Micro-CT) is a 3D imaging technique utilizing X-rays to see inside an object, slice by slice. It is similar to a CT scan, but on a micro-scale. Micro-CT provides high resolution 3D imaging of the interior structure of materials and biological samples without having to cut the samples.

The aortic valve of the human heart typically contains three leaflets or cusps, hence called the tri-leaflet valve. When the valve opens it allows blood to exit the left ventricle into the aorta. Once closed, blood movement stops. In the case of a dysfunction, the tri-leaflet valve is repaired or replaced by a surgery. The technology described in this article provides a promising approach to create artificial implants for these surgeries.

Hydrogels are 3D networks of hydrophilic polymers that can hold a lot of water while still maintaining structure. They resemble tissue structure when scaffolded and can nurture cell growth and vessel formation. Hydrogels can be assembled by chemical processes. In this study, authors used pH-driven assembly (gelation).

Micro-computed tomography (Micro-CT) is a 3D imaging technique utilizing X-rays to see inside an object, slice by slice. It is similar to a CT scan, but on a micro-scale. Micro-CT provides high resolution 3D imaging of the interior structure of materials and biological samples without having to cut the samples.

Negative Nb anomalies are characteristic of subducted material. Subducted material includes continental-sources sediments from the ocean floor that gets subducted into the mantle. The trace element patterns look more like the crust than the mantle, which means that the fluid inclusions' trace element record is not recording any mantle processes.

A kind of intrusive, igneous rock that is formed deep inside the Earth’s interior. Kimberlite tends to move upwards via the upper mantle and lower and upper crusts, ultimately reaching the surface of the Earth. When the rocks move up, they carry diamonds inside them, thereby becoming an important source of diamonds.

A slab is a part of the tectonic plate which undergoes subduction. Subduction is a geological phenomenon occurring at the junction between two tectonic plates. This involves pushing one plate below the other, so much so that the sinking plate (usually the denser one) protrudes into the Earth’s mantle.

The mid-ocean ridge is one of the largest chain of volcanic mountains on Earth, with 90% of the mountains submerged underneath the ocean. A type of basaltic rock originating from volcanic eruptions in this region is known as mid-ocean ridge basalt.

Mid-ocean ridges occur where two tectonic plates pull apart and the mantle below wells up and then rapidly cools due to the interaction with the ocean's cold water. This is what makes up oceanic crust.

This occurs when magma inside the Earth's mantle gets polluted by small amounts of crustal rocks—that is, rocks from Earth's crust. Shallower crustal rocks are more felsic, which means they contain more feldspar and quartz.

A pill that stays in the stomach during drug release.

Analysis of Variance - statistical test used to determine whether there are any statistically significant differences between the means of three or more independent observables.

Any body fluid outside of the cells in any multicellular organism. This includes interstitial fluid and plasma.

A smart pill that stays in the stomach during release of a drug (levonorgestrel) which prevents pregnancy.

an electric field/charge that is stationary

a device that stores electrical energy between two conducting electrodes separated by a dielectric (nonconducting) material

when a voltage is applied between electrodes pressure arises, the elastomer contracts in thickness and expands in area.

occurs when current flows through a material whose electric charges do not flow freely

A device which generates movement from electrical energy. The device consists of liquid segments which helps amplifying force generation and heals itself in case of an electrical breakdown.

The peak specific power is the maximum power that the power supply can sustain for a short time.

An endoscopic overtube is a sleeve-like device designed for both upper and lower endoscopic procedures. During upper endoscopy it is designed to protect the hypopharynx from the trauma of repeated intubations, the airway from aspiration, and the esophagus during extraction of sharp foreign bodies.

A branch of pharmacology which studies how drugs are taken up, distributed, metabolized, and cleared from the body.

A biodegradable polymer substance used in drug delivery applications

A patients commitment (how well a patient follows prescribed directions) to taking said medication at the correct time each day.

A silicon based elastomeric polymer used in biomedical applications.

methods of birth control which impacts hormones related to pregnancy

in live being

A drug or device used to prevent pregnancy taken as a pill by mouth.

the action of causing a machine to operate

denoting, relating to, or operated by a liquid moving in a confined space under pressure.

a subcategory of robotics that deals with the construction of flexible robots to mimic living organisms

a lightweight, affordable, and easily customizable device component consisting of flexible material that converts energy into mechanical movement in order to move/control a part of the device

deformation produced by a non-mechanical stimulus

a material that produces a large deformation when a voltage is applied

man-made fibers consisting of synthetic chemicals

a device that converts an energy signal in to another form of energy signal

an example of this is mechanical energy being converted to electrical energy

a gel which contains significant amount of water and can conduct electricity

an electrical conductor that makes contact with nonmetallic parts of a circuit

the most widely used silicone based organic polymer

Simply put, resonant frequency is the natural frequency at which it is easiest to get an object to vibrate. Most objects have several resonance frequencies, such as stringed musical instruments that vibrate at their resonance frequencies when plucked or struck, and their vibrations against the surrounding air produce sound. This type of resonance is found when an object is in equilibrium with acting forces and could keep vibrating for a long time under perfect conditions.

An actuator creating movement in a straight line, rather than a circular motion.<br> In this study, a fixed pre-stretch is applied in one direction (downward pull).

the ratio of total deformation to the initial dimension of the material body upon application of external forces.

this ability of a material to hold an electrical charge

a device component which uses hydraulic fluid pressure to convert energy into mechanical movement in order to move/control a part of the device.

Newborn child

Migration of cells into microporous structures.

A semiliquid mixture, typically of fine particles of manure, cement, or coal suspended in water. E,g, cake batter

Heart muscle cells responsible for contracting of the heart.

Scaffolds provide support for tissues and organs in the human body. In this article, the scaffolds are made from collagen, a structural protein used in connective tissues

A network of biological materials surrounding cells throughout the body for protection and support.

The ability of cells to occupy the porous structure in the hydrogel to create a tissue-like structure

Highest amount of force an object can take before deforming.

A scale from 1 to 14 determining how acidic or basic a solution is. 1 is most acidic, 14 is most basic, and 7 is neutral.

Reproducibility of features (size and shape) with 3-D printing

cells removed

Reproducibility of features (size and shape) with 3-D printing

Smallest feature that can be written by 3-D printers.

Grasslike plants.

Interactions of physics and chemistry.

When the direction of an ecosystem change cannot be reversed, i.e., an ecosystem cannot be returned to its previous state once it has gone through a phase shift.

Killing other organisms for food.

Research involving more than one field of science, e.g., biology and chemistry.

Complex cycles of nitrogen, sulfur, phosphorus, carbon, and water involving the atmosphere, land, water, and organisms.

The interactions between organisms and the nonliving environment (i.e., rocks, water) within an area.

The impacts that top-level predators have on the food web levels below them.

The storage of carbon atoms in organisms, soil, and water from the atmosphere

When large stretches of land are covered by lava generated from a massive volcanic eruption, a type of basaltic lava is created. Sometimes, these eruptions are also caused by movement of tectonic plates in the lithosphere. Such events when combined with abnormally hot rock in the Earth's mantle (mantle plume), give rise to continental plume-related basalts.

It is the process of removal of dissolved gases from liquids, especially aqueous solutions.