Of course CD40 signaling inhibits differentiation. The data shows that longer treatment with CD40 antibody decreased differentiation compared to 24h of treatment.

BBC includes this statistic to show the reader the effect that this spread is having on the consumers, reiterating why this is a big deal.

BBC is using a credible, factual source for their information about the E. Coli spread.

.

Lets Suppose the roundtrip takes 5ms and retransmission happens every 4ms Then roundtrip exceeds retransmission, means new sync request will be triggered before recieving ack from prev req, which will lead to high number of packet req until the saturation point is reached

UMD's robotics department has student projects in collaboration with gemstone that do very similar things.

I think that's a good idea, especially for elderly who might get confused by a humanoid robot talking to them if they have a cognitive disability.

Why do we think older people will especially resist care from robots?

Japan has a very large elderly population and a smaller population of young people, which is what makes it so difficult to find enough people to take care of the elderly.

This would be very helpful for older people who cannot control their bladder. When people have memory loss, they can forget that they have to use the bathroom, so maybe by having a robot remind them, it can help them slightly with their memory.

oh, um, that escalated quickly.

Is Magic about to happen? I hope so!

I'm confused with the punctuation.

What exactly is this trying to say? Did they steal it, was it out of kindness? I'm confused.

Who's the "her" referring to?

Self view

Love the word choice.

the grayness mentioned again

i think this is the first piece of action Ive read in this piece omggggg

im wondering the same

interesting statement

im still wondering if the underscores have significance. does it represent them maybe saying it in a different language and it's translated?

I like this phrase idk why

wow

I hate the terms owner and master yuck

if they want to be like the emigrant ship then why aren't they trying harder than they are to be like it?

weaponizing humans

I would be the same ngl. why does kindness matter when you're being physically tortured?

is this worded weird or can I just not read?

wow hello generalization and racism

reminding of before: the calm before the storm. are we now getting to the storm?

ooo gossip

never seen this term before. is it the plural feminine form?

do the underscores have significance?

hmmm

so is the stranger the boat? maybe I missed some context

traditional garment consisting of a skirt and veil to disguise the wearer's identity

the ship? gendered?

this captain can't steer apparently

Is he now scared of all black people?

a reasonable response?

Negative stereotyping that re-enforces the belief that black individuals are not being treated equally as previously stated

This seems unlikely given past descriptions of their actions

Overall getting the message that Melville is trying to depict old Europeans as monsters and Americans as more "humane"

In general this document is an educational description of the process of enzymes being used as biological catalysts and the different mechanisms that are utlized in the process as a whole

Does a process like this occur when enzymes are used by bacteria to counter antibiotics?

How substrates bond and what happens once they do

Another key term, includes link with extra information(read later)

Key terminology

The first statement appears to be a general statement of the material to be discuessed further in the document based off the title

General introduction to the purpose of the following subsection of this article

Spending hours on reading the documentation and guide lines of the host Canadian unitiverity

is the only options

This sentence is interesting because it is true that media is a skill to be learned. We must learn how to learn the different types of media in order to gain the knowledge that we need to progress in this world as well as use it in our everyday lives. Without this skill, how can we progress or advance in the world since everything is digitalized?

The term "mediatized environment" reflects the context in which we operate, implying that media is not just a tool but a significant context that influences thoughts, behaviors, and societal structures.

The benefits outlined (e.g., GPS navigation, and finding restaurants) showcase how these technologies enhance convenience and accessibility, making daily tasks more manageable and efficient. The ease of maintaining relationships through social media illustrates how ICTs facilitate social connectivity, enabling users to engage with a broad network of friends without significant effort. The robust interconnection highlights the role of ICTs in shaping and enriching our social and cultural environments, suggesting that technology serves practical purposes and influences our social lives and identities.

This framework underscores the complexity of interactions between various dimensions of human experience and media technologies. Each grouping (technological, sociocultural, etc.) represents a critical lens for understanding how individuals engage with media. Highlighting technological relations indicates a prioritization of how digital tools shape human behavior and identity, suggesting that these tools are central to modern existence.

preload = volume of blood returning to heart to the right atrium

afterload = resistance

contractility = how hard the heart gotta work

Beta 1 adrenergic receptors = gas pedal for the heart, increases HR and contractility

Beta 2, alpha 1 = vasoconstriction

M2 = acetylcholine binds to M2 leads to slowing of heart rate

heart cant pump properly, less blood is reaching the rest of the body

don't take phenylephrine which is worsening the workload of her heart

Dilated cardiomyopathy can lead to atrial fluttering, because heart muscles are stretched and damaged, lead to abnromal condcution

Amlodipine = non-DHP, only works to dilate the blood vessels and has no effects on heart like verapamil (which lowers AV conduction / decreases contractility of the heart)

Phenylephrine = selective alpha 1 agonist, causes vasoconstriction which worsens HTN

more calcium = more contractility

when calcium levels rise it bind to troponin and increase contraction, which increases stroke volume -- more blood pumped out with each beat

Orthopnea is the sensation of shortness of breath (dyspnea) that occurs when a person is lying flat and improves when sitting or standing up. Associated with HF (When lying down, the redistribution of fluid from the lower extremities into the chest increases the pressure on the lungs, exacerbating the difficulty in breathing.)

pulse oximetry = difficulty delivering blood to body

central cyanosis = related too the low oxygen delivery to the body

Jugular Venous Distension = related to right sided HF, dilated and restrictive cardiomyopathy (right atrium pressure builds up because blood keeps regurgitating back to RA, then it backds up into the veins))

Peripheral edema/crackles = from pulmonary congestion since blood be backing up

How will climate change affect this weather? Will it make this area less conducive to farming and growing crops and sustaining life?

Is the conflict being referred to mainly between ethnic groups or tribal conflict? Or is it referring to conflict between the state and the citizens?

• E1 activates ubiquitin and transfers it to E2
• E2 is positioned close to the target by E3
• E3 transfers ubiquitin from E2 to the target

"Eukaryotic cells contain multiple versions of the E3 ubiquitin ligase known as the SCF (Skp1/cullin/F box), each of which is distinguished by a different F box protein that uses a domain at the carboxyl terminus to recognize substrates for ubiquitination. The F box protein Dia2 is an important determinant of genome stability in budding yeast"

Because Mcm7 cannot be ubiquitinated, CMG is constitutively bound to DNA, and will not be removed at any point in the cell cycle. This means that when the cell divides, it will divide it's DNA with CMG still loaded, and the next round of DNA replication will be impaired.

The authors mutated a region of the Mcm complex, specifically Mcm7, seemingly through a mutation at residue 10 from lysine to arginine, making it impossible to be ubiquitinated by SCF-Dia2.

Ubiquitnation leads to CMG unloading, via ubiquitylation, via disassembly by Cdc48/p97, so this mutation makes the CMG constitutively bound to DNA.

Cells with the Mcm7-10R mutation could not be ubiquitated and therefore CMG could not be disassembled.

However, this did not lead to cell death, because a secondary disassembly pathway using Rrm3 and Pif1 helicases was enacted.

Without CMG disassembly, cells were not viable and the ability to ubiquitinate new helicases was lost? It seems.

Cells that have the MCM7-10R mutation will carry the CMG complex on their DNA into the next cell cycle. This helicase must be removed to make way for new helicases and further DNA replication.

The authors found that Rrm3 acts during S-phase to disassemble the CMG complexes from previous cell generations.

Pif1 is a helicase responsible for the maintenance of nuclear and mitochondrial DNA in S. cerevisiae.

Pif1 tightly couples ATP hydrolysis, single-stranded DNA translocation, and duplex DNA unwinding.

So how would they be able to truly come up with an effective solution to the problem that they have not seen themselves?

Which one is the most beneficial for the elderly?

This is the recommended reading from our textbook for =Week 9=

Please, try to annotate it as much as possible!

female body is the states means of reproduction!!!!!!!!!!!!

Korean gov institures 3rd plan, effort to improve state of declining marriage and threat of lower birth rate. emphasis on female fertility, extra support for newly married couples blamed womens ferility

blame childless generatoin on neoliberlism

policies and laws did not help

The ship has sailed for Harris when it comes to Middle Eastern voters. Between her administration's involvement in the middle east in the last 4 years and her now attempt to sway voters with Cheney, I think it is best for her to move on from this sector.

I don't like when politicians, on any part of the political spectrum, use people as spearheads for their political campaign. If Michigan voters like Kamala enough, they'll vote for Kamala, I don't believe Liz Cheney(Ex-Rep of Wyoming) is going to sway anyone, especially not Michigan republicans.

Internet access for queer men gave freedom to learn and understand themselves and where they belonged, ultimately helping them feel less alone. It did not matter where they lived, the internet was a safe place they could go to not worry about the confines imposed on them in the real world. Without such opportunities and freedom gay men would have otherwise succumbed to the loneliness and rampant homophobia of the 90s

This is crucial to note because although the competition seems cut and dry there is a loophole for legal action.

This is important because if the DOJ decided to speak it could of backfired and caused chaos.

The most well-known example in the hacking of metadata is the 2014 celebrity photo leak, or as most know it, "The Fappening". A number of celebrities were hacked through poor security on their iCloud accounts to reveal private photos. Although the content itself was private, they knew more through metadata in those photos, location data encoded in these photos, for example.

This is a good thong for republicans. If I recall, last election there were countless more early voters for the democratic party.

When people see a couple who fit this description in the community I often overhear conversations and comments which reinforce this stereotype. It is a stigma based around an assumption that both are trying to get one thing off the other. Moreover, wealth from the older white man, or youth and beauty from the Asian woman. It is less likely people will believe they are truly in a loving interracial relationship.

Asian women are more sexualized as they are often depicted as a male fantasy in the West, however the same does not go from Asian men. This may explain the contrast in interest between the participants as although Hannah needed to adapt she was not outright avoided like her male Chinese counterparts.

Metadata can sometimes be surprising in the way that it can violate privacy. For example, many photos and messages have embedded location data in them-meaning that others can know where you have been at any given time, and you might never know that such a trail exists. Moreover, the websites collect browsing metadata with the intention of tracking your online activity. Even combining metadata from different sources, companies can create an extremely detailed picture of you without needing to access the actual data.

This is so important and we should welcome the assets of all individuals.

These days, my friends talk about the inferences that could be made based on the types of accounts that they follow. Sexual orientation is one that frequently pops up along with what kind of personality they have or what hobbies they enjoy. An easy giveaway is if they are following certain brands or locations.

I think this is wrong. Although the platform can recommend better content to us after getting our information, such behavior will cause trouble to users. When people do not want their information to be discovered by others or their interests change and they are tired of their previous interests, seeing the content pushed by the platform based on data mining will make users irritated.

Thank you for sharing this work! Negative data is published much less frequently, it's great that you put this out here.

Regarding your results, you mention several times that the Trim7 antiviral phenotype comes from an in vitro overexpression system. It seems like you may be attributing the lack of activity in vivo to due to lower expression levels in the mouse. I would be curious to know if in vitro you also see a strong dose dependence, where Trim7 can only restrict viral replication at high expression levels.

If the differences are driven by expression levels, one interesting explanation might be that MNV has a natural inhibitor of Trim7, and only when you overexpress Trim7 do you see antiviral effects. I used to study anti-CRISPRs (phage encoded inhibitors of bacterial immunity), and we would see a very similar dynamic. In our experiments, if a phage had an anti-CRISPR, it would appear to be unimpacted by the CRISPR-Cas immune system, but if we overexpressed CRISPR, we could "overwhelm" the anti-CRISPR and the phage would fail to replicate.

If you have any genomic libraries of MNV it could be interesting to see if any MNV ORFs are able to rescue MNV growth in the the Trim7 cell line.

this is now the second time in the past couple of weeks this drug has come up in recent news stories

according to this article his cause of death was due to the fall but the drugs taken lead to his fall.

the people who were with Liam when he died foresaw what ended up happening. This source is directly from the hotel receptionist

this drug is very unstable and how people react to the drug can vary drastically.

pink cocaine is a drug that is on the rise and is a mix of multiple different illegal substances.

I like taking written notes for a lot of things, mainly because I not only feel more engaged with the information being presented to me, but it also ensures that I'm only writing down what's important as I typically can't write as fast as the presenter is talking. That way I'm not left with a bunch of extra stuff in my notes that makes them more confusing and "stuffy" if you will.

Does this not amount to a suggestion that we outright abandon the principle that the law should apply to everyone equally?

This is a stronger critique of the argument - here the point made is that you can hardly argue there's a moral responsibility to make the victim whole where proper consideration as to why the defendant acted in that way has not been given - however here the author appears to be assuming that the only remedy a court will award is that the plaintiff be made whole

The weakness in this argument is that the author fails to explain how this sort of compensation is more than ordinary morality would demand. Upon reading this point it seems entirely reasonable for the wrongdoer to be responsible of ensuring the victim of their careless action retains the same standard of living they had, had the defendant not acted in this manor - the argument would be more effective if the author actually delve deeper in explaining how this contravenes 'ordinary morality'.

In all of these examples you could apply Perry's theory of responsibility, the law in nature is all centred around holding wrong doers responsible for their actions, however the main difference here in the civil recourse theory is that its simply analysing this dynamic through the provision of aid by the state in assisting in the endeavour of holding wrongdoers accountable.

Rights of Action and remedy

So the benefit of the responsibility approach is that it justifies why someone should be liable for a harm caused, or why they should owe nothing to the victim by having established a mechanism allowing an analysis to be undertaken as to whether or not someone is 'morally' liable

So the proposal of the 'responsibility approach' to tort is that under tort someone will be liable if they are (A) responsible for the outcome, and (B) morally responsible for causing that outcome.

The banner/general proposition of the responsibility approach to tort law

An outline/summary of the content of the responsibility approach to tort law

Key summary of modern tort law.

.

Case#: Patient 2, Turkish, 4 years old (report)

DiseaseAssertion: Accumulation of guanidinoacetate in brain and a deficiency of creatine in blood. GAMT deficiency in the liver.

FamilyInfo:

CasePresentingHPOs: HP:0011344, HP:0001252, HP:0001251 (Severe developmental delay, muscular hypotonia, ataxia)

CaseHPOFreeText: Intractable seizures, Bio- chemical and spectroscopy findings were similar to those of patient 1

CaseNotHPOs:

CaseNotHPOFreeText:

Biochemical analyte testing:

Brain Magnetic Resonance Spectroscopy (MRS):

GAMT activity assay: Total RNA from liver, fibroblasts, or leukocytes. The residual GAMT activity varied between levels below the limit of detection and 1.9 units/g liver. When 1:1 mixtures of liver extracts from the two patients and control livers were incubated, the GAMT activity exceeded the calculated activity by 40%-60%. This excludes the possibility that the deficiency of GAMT in the patients' livers is due to an inhibitor. It, rather, points to the presence of an activator of GAMT in the patients' livers. The activities of two unrelated enzymes (cytosolic lactate dehydrogenase and lysosomal ,B-hexosaminidase) and the protein content, which served as reference parameters, were within the same range of controls (table 1). Taken together, these results confirm the suspected deficiency of GAMT activity in the liver of the two patients.

Zygosity: Homozygous

Variant 1:

ClinVarID:

CAID:

gnomAD:

Variant 2:

ClinVarID:

CAID:

gnomAD:

ParentalGenotypes:

PreviouslyPublished:

Case#: Patient 1, German, male, 22 months old (report)

DiseaseAssertion: Accumulation of guanidinoacetate in brain and a deficiency of creatine in blood. GAMT deficiency in the liver.

FamilyInfo:

CasePresentingHPOs: HP:0008947, HP:0007153, (Infantile muscular hypotonia, Progressive extrapyramidal movement disorder,

CaseHPOFreeText: emiballistic voluntary movements, at the age of 22 mo his developmental age was that of a 8-wk-old infant,

CaseNotHPOs:

CaseNotHPOFreeText:

Biochemical analyte testing:

Brain Magnetic Resonance Spectroscopy (MRS): Bilateral abnormal signal intensities in the globus pallidus. A severe deficiency of creatine and creatine phosphate and simultaneous accumulation of guanidinoactetate were detected by in vivo proton and phosphorous magnetic resonance spectroscopy of the brain.

GAMT activity assay: Total RNA from liver, fibroblasts, or leukocytes. The residual GAMT activity varied between levels below the limit of detection and 1.9 units/g liver. When 1:1 mixtures of liver extracts from the two patients and control livers were incubated, the GAMT activity exceeded the calculated activity by 40%-60%. This excludes the possibility that the deficiency of GAMT in the patients' livers is due to an inhibitor. It, rather, points to the presence of an activator of GAMT in the patients' livers. The activities of two unrelated enzymes (cytosolic lactate dehydrogenase and lysosomal ,B-hexosaminidase) and the protein content, which served as reference parameters, were within the same range of controls (table 1). Taken together, these results confirm the suspected deficiency of GAMT activity in the liver of the two patients.

Zygosity: Homozygous

Variant 1:

ClinVarID:

CAID:

gnomAD:

Variant 2:

ClinVarID:

CAID:

gnomAD:

ParentalGenotypes:

PreviouslyPublished:

PMID: 8651275

Gene: GAMT

Disease: GAMT deficiency

Inheritance: Autosomal Recessive

This signifies control. People simply looking for job prospects and opportunities were being played like chess pieces for the pleasure of these high-power men.

I think it is so important for victims to feel comfortable to come forward and to not let their abusers to continue having power over them. I think the public needs to be more accepting to victims of these crimes and not just turn a cold shoulder because the person being accused of the crimes is influential.

Similar to Jeffrey Epstein. That case was so important for all the cases following after that, it encouraged victims to speak up and let their voices be heard.

These NDAs signifies the use of intimidation and sparking fear within people.

I feel like these sorts of cases continue to come out more and more. The Hollywood industry, which I would assume these men were apart of, does a terrible job at protecting vulnerable people who are looking to make social connections. Rather, people in high power continually take advantage of innocent people.

Were these victims also people who worked under him? The party setting also reminds me of the huge case revolving around P. Diddy at the moment.

This seems very similar to the Harvey Weinstein and #MeToo Movement. People see an incredibly wealthy and influential man who does not use his power for good, rather he abuses it.

Yes, this would mean we are ERGODIC and not just a 501c3 and not just an FSC

YEs Kauffman will fund a company that is NOT a not for profit if its terms of assocaition say it has a charitable function. 501c3 for kauffman is all about TAX ANd yes, we can set up an LLC with an FSC bye laws just as easily

Paul will createa 501c3 as a RESEARCH instrument to apply for Kauffman;s research grant My hope is that IAN's 501c3 will apply for the PROJECT Grant that holds the eco-system of 501c3 fair shares commons

So nto everyone has a telegram account so that is even a splinter group even though it was asked for by some members of the team So we still have an email list and a telegram grop and they are not synchrinised

The meeting with Gyuri was a request from him to meet PAUL so that we could ground on the threads for the RESEARCH application I asked Donan to attend but I did not not ask others to attend as I do not want to place demands on people's time and space This is why I recorded it and sent it around If people then ANNOTATE the call the way I am doing here, Gyuri has data that he can use to develop technology based on what he is himself involved in and not just as a service provider

This is where SROI (Social Return on Investment) DATA will help us bridge the gap In a recent call in Ireland a football team scored a 17:1 SROI score for their impact on community

Kauffman is just our sandbox. We may NOT get their funding. But as soon as we have clarity, structure, documents, templates, we will find the right funder

Tapping to the MMT theory, if a 501c3 is not taxed, then why does it need dollars??? We are close to some understanding some fundamental incoherencies

We welcome the idea of HYBRID SOCIAL ENTERPRISE which can have profit making processes that are professional and not for profit processes which are vocational

Not for Profit is a way to infiltrate the parasite of PROFIT that has come to symbolise incorporation

The reason we are setting up a 501c3 is that the donors have made it easier to receive funding beacse they get a tax write off

Why isnt Evolutesix then the most profitable FSC that it can be?

It is unsafe to assuem that we all knwo hwo a company is incorporated Even senior executives do nto know how their companies are incorporated Most SME founders do NOT know the meaning of how their company is incorporated

Thank you Marie. You embody the SPIRIT of a 555 FSC

Can we all know and understand this graphic. It is quite deep in the powerpoint.

Could we begin to use organism rather than organisation?

if we speak into the incoherence, we might creaet more of it?

We also need to fund a way to create a currency which also has at least the same level of systemic trust as money

The plan is to create a pool of learning and documents so that any one of us can apply for funding to create an FSC with a 501c3 as the legal entity with FSC bye laws that can be adapted

The emergenrt natur eis that we are holding spoace for the creation of an eco system of 501c3's with FSC bye laws

This is why we are raising the money - to offer this benign parenting support of helping us all to pay for what we need so that we do what we love For now, I am using thew term Universal Learning Income

I have realised why COLLABORATION is limited. The word only relates to LABOUR. It is only that we share work. We do not share heart, love, prayer, food, shadow, time, space, etc etc

CHECK AND TWO SECONDS PAUSE

As a Dialogue group, we have the chance to practice allowing the other to end their sentance, for which they can say CHECK Then TWO SECONDS Then the next person can join from the eternal silence

We are hoping to create a COLLECTIVE COMMONS for our annotations The ancient model is the Celtic SPirtual ANNAL such as the book of kells or Leabhar Gabhala (Book of INvasions) where multipel wisodm keepers over generations add their wisdom IN BETWEEN THE LINES

For now, Gyuri and Gien call it Hyperpost

We are using hypothesis (as in this annotation) to play with what tools we have now

Gyuir and Gien intend to make it CROSS PLATFORM

They are using the term INDYWEB and INDRAS NETS

Thank you so much for creating the meeting and for holding space It is not intended that any one person ought to be a central point of contact We are to become autocatalytic - energies arise and fall and all that is is and all that is not is not Some people will not show up Some people will show up all the time We are all equally included We are all One

call to action for players

players should be able to disconnect after a game the same way employees disconnect from work. These messages don't allow them to do so

direct evidence of how these messages impacts a player's thinking

same idea that was expressed in the Blame Game article I read

proof that this is a relevant issue and should not be overlooked

another direct experience with the issue

the city centers of large urban centers

the study shows different family types including their traditition

The institute

All products made in the USA need this USDA approval, so it is interesting that this wasn't caught earlier.

If true they need to fix that immediately, but it might not be the end of the company. Other companies have had similar issues when starting up, so it is only normal.

This could be the issue. Real cheese molds much quicker if not chilled correctly in shipping.

This is an important part to mention, since the product is new, having the cheese mold is not a good sign. either they are lying about how old the cheese is, or the specific blend they use is much less artificial and rots quicker.

I find this hard to believe even with the pictures, as the product was just launched mere weeks ago. If true this could be a quick end to the company.

Why and how are they bestfriends? - would have been a nice inclusion

I feel as if the author could've had alot more detail in this article if it was not posted during the 2nd quarter rather the end of the game.

It would've been nice for the author to incorporate a year that the previous record was set in.

This could be looked at as bias since Charean Williams says, 'The Ravens needed it" which comes out to be an opinion when in reality they really did need it to keep up in the game.

While the article was not focused specifically on how hurtful social media backlash is on athletes, I think it does showcase the extremity of some of these fans. Fans like this take abuse to the next level and the article highlights that while providing some solutions that could be helpful in mitigating the issue

yet another solution. But can you apply this to everyone who posts negative things?

another way to respond to hate. Similar to a solution from last week's article

seems like the article is focused on hate but not towards athletes in specific

This is interesting, I didn't actually know that there was a change in views on race in this time period, I thought that was a much more modern concept.

Ironic, given that slavery was still widespread in some places post-Revolution, meaning that all did not, in fact, lay claim to that freedom.

Interesting, because regardless of the actual activism, wasn't Haiti forced to pay a ridiculous sum by the French that left the country economically crippled? I wonder if some people were discouraged by that, and what the response to those arguments was.

Thi sis a annotation on this line

who cares what this says ... the point?

the daughters of "men" are aliens; and all united against God himself, the cutest little puppy that was ever created; and forced to listen to dave sing ...

coud i have been?

your little sister? anyone ... other than me?

https://www.youtube.com/watch?v=B9Ol1Rd9ABI

could i have been?

is this about or at gabriel, or taylor; or the source of Manhattan, or Hatteras; or the world that didn't even know what a "tt" was before there was a Sloan? Remember the days I refused to call Tay "tee" ... before "tee tea" had something to do with ... "keys"

little boy blue and the man in the moon ... when you cummings, georgia tech?

# you know we'll have all the tech giants then.

https://biogarabatos.blogspot.com/2024/10/the-rogue-scholar.html

Gradient of the text needs to be changed, see figma

Awesome to allow readers to learn more about E. Coli bacteria. The author gives readers a short summary of her own, and provides us with a direct link to the CDC.

This paragraph gives readers a possible answer for what is causing the outbreak. Although earlier sentences state there is no official cause, there are possibilities.

This is impact. It is affecting a lot of people. Ranging from those who already ate a Quarter Pounder to those who were interested in purchasing one.

Author Jonel Aleccia lets us readers know where she got her information to write this article, and provides us with the link to easily access it.

From this point of view, I think the disadvantages of data mining outweigh the advantages. Although data mining can improve the user experience, when the platform uses this data to make profits, it will harm the users. It puts the cart before the horse and turns something that should serve the users into something that hurts the users.

Word shading supposed to look more pink at the word 'Moment!'

There is supposed to be an arrow at the end of this -> See figma

Delete, also delete all XX on the other cards here

Font color = dark blue Font size = same as the segment below, "Download our Free STEM Activities..." currently the text here is larger than what's below

Agrandir font

Line spacing to be wider between lines

Missing - 3 boxes. see figma

Supposed to have multiple banner images here. See figma.

Also the words 'imagination' and 'flight' are supposed to be in yellow

Reviewer #1 (Public review):

Summary:

Juvenile Hormone (JH) plays a key role in insect development and physiology. Although the intracellular receptor for JH was identified long ago, a number of studies have shown that part of JH functions should be fulfilled through binding to an unknown membrane receptor, which was proposed to belong to the RTK family. In this study, the authors screened all RTKs from the H. armigera genome for their ability to mediate responses to JH III treatment both in cultured cells and in developping animals. They also present convincing evidence that CAD96CA and FGFR1 directly bind JH III, and that their role might be conserved in other insect species.

Strengths:

Altogether, the experimental approach is very complete and elegant, providing evidence for the role of CAD96CA and FGFR1 in JH signalling using different techniques and in different contexts. I believe that this work will open new perspectives to study the role of JH and better understand what is the contribution of signalling through membrane receptors for JH-dependent developmental processes.

Weaknesses:

Unfortunately, the revised manuscript does not show significant improvement. While the identification of the receptors is highly convincing, important issues about the biological relevance remain unaddressed.

First, the main point I raised about the first version of this article is that the redundancy and/or specificity of the two receptors should be clarified, even though I understand that it cannot be deeply investigated here. I believe that this point, shared by all reviewers, is highly relevant for the scope of this work. In this revised version, it is still unclear how to reconcile gain and loss-of-function experiments and the different expression profiles of the receptors.

Second, the newly added explanations and pieces of discussion provided about the mild in vivo phenotypes of early pupation upon Cad96ca or Fgfr1 knock-out do not clarify the issue but instead put emphasis on methodological issues. Indeed, it is not clear whether the mild phenotypes reflect the biological role of Cad96ca and Fgfr1, or the redundancy of these two RTKs (and/or others), or some issue with the knock-out strategy (partial efficiency, mosaicism...).

Finally, parts of the updated discussion and the modifications to the figures are confusing.

many sections feel like they stand on their own, large contrast between these two stanzas

I personally have to work with data a lot and line graph are one of the chart I use the most to show how value of items can change over time.

While this report highlights of drugs that have shown up in the toxicology reports, it is important to note that he was human and he had many friends, family, and fans who cared about him. It's important to end such a heavy article like this to make it more sensitive rather than insensitive.

Could this death have been prevented if authorities or someone had taken action quicker?

This 911 call is important to add to news stories because there were things that people noticed before the star fell to his death. This call serves as a witness to this tragic death and is beneficial to reporting as well as determining what actually happened.

The headline is straight and to the point, but we should emphasize the word "reportedly." This implies that this is not 100% percent confirmed, but it is in speculation and possibility.

The toxicology and autopsy report of this star's tragic death has just been released which is very recent. There were many speculations in the media about how Liam Payne died because it wasn't completely apparent at the scene of his death. News like this can give readers the opportunity to creative new feelings for this situation as well.

This is important to note when analyzing content. NBC News admits that have yet to completely confirm the sources they used so readers must take "facts" with caution.

This is very similar to what the NFL does with Redzone where they show all the action from all the games

I think this is very human interest focused because they obviously brought it back because all the NHL fans across the world enjoyed it very much

I think this is a good way to open their article because it makes people actually think "Why are the games starting so early"