• for: Michael Levin - slime mold experiment, question - new theory of consciousness from a single cell

• question

  • is it possible that a theory can be constructed to explain consciousness from the behavior of a single cell organism such as a slime mold?

• for: example, example - MET and FET insufficient for MST

• example: MET and FET insufficient for MST

• paraphrase

  • Eukaryotic single-celled organisms appear in the fossil record by approx. 1.6 BYA (Knoll et al., 2006).
  • Yet for a “boring billion” years of evolutionary history, they remain minor components in bacterial-dominated ecosystems
    • before explosively radiating as large, multicellular species in
      • an Ediacaran and
      • Cambrian MST.
  • Eukaryotes are obviously essential for this MST, as all
    • animals,
    • plants and
    • fungi

  • are eukaryotes.

  • However, the initial appearance of eukaryotic cells seems insufficient for a MST

High-throughput single-cell proteomics quantifies the emergence of macrophage heterogeneity | SCP2019 https://youtu.be/NNLh4nE687I

Optimizing single-cell analysis of proteins and RNAs | Nikolai Slavov | SCP2020 https://youtu.be/LkNMskjxYXA

Droplet sample preparation for single-cell proteomics | Andrew Leduc | SCP202 https://youtu.be/DJ1U_KpMNcY

Lee, J. W., Su, Y., Baloni, P., Chen, D., Pavlovitch-Bedzyk, A. J., Yuan, D., Duvvuri, V. R., Ng, R. H., Choi, J., Xie, J., Zhang, R., Murray, K., Kornilov, S., Smith, B., Magis, A. T., Hoon, D. S. B., Hadlock, J. J., Goldman, J. D., Price, N. D., … Heath, J. R. (2021). Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19. Nature Biotechnology, 1–11. https://doi.org/10.1038/s41587-021-01020-4

Xu, G., Qi, F., Li, H., Yang, Q., Wang, H., Wang, X., Liu, X., Zhao, J., Liao, X., Liu, Y., Amit, I., Liu, L., Zhang, S., & Zhang, Z. (2020). The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. MedRxiv, 2020.08.15.20175638. https://doi.org/10.1101/2020.08.15.20175638

Xu, G., Qi, F., Li, H., Yang, Q., Wang, H., Wang, X., Liu, X., Zhao, J., Liao, X., Liu, Y., Amit, I., Liu, L., Zhang, S., & Zhang, Z. (2020). The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. MedRxiv, 2020.08.15.20175638. https://doi.org/10.1101/2020.08.15.20175638

Unterman, A., Sumida, T. S., Nouri, N., Yan, X., Zhao, A. Y., Gasque, V., Schupp, J. C., Asashima, H., Liu, Y., Cosme, C., Deng, W., Chen, M., Raredon, M. S. B., Hoehn, K., Wang, G., Wang, Z., Deiuliis, G., Ravindra, N. G., Li, N., … Cruz, C. S. D. (2020). Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19. MedRxiv, 2020.07.16.20153437. https://doi.org/10.1101/2020.07.16.20153437