1. Jan 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Brain inflammation triggers macrophage invasion across the blood-brain barrier in Drosophila during pupal stages
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    pmc.ncbi.nlm.nih.gov/articles/PMC8550232/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing mask activity in dopaminergic neurons extends lifespan in flies
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    pmc.ncbi.nlm.nih.gov/articles/PMC8590106/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites
    18
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    pmc.ncbi.nlm.nih.gov/articles/PMC8728012/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC8572659/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes
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    pmc.ncbi.nlm.nih.gov/articles/PMC8496270/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors
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    pmc.ncbi.nlm.nih.gov/articles/PMC8522278/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology
    14
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    pmc.ncbi.nlm.nih.gov/articles/PMC8546075/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC9502878/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis
    3
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    pmc.ncbi.nlm.nih.gov/articles/PMC8665130/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan
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    pmc.ncbi.nlm.nih.gov/articles/PMC8607513/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Novel Variant of ATP5MC3 associated with both dystonia and spastic paraplegia
    4
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    pmc.ncbi.nlm.nih.gov/articles/PMC8840961/
  13. www.medsci.org www.medsci.org
    Microarray Analysis of Differentially-expressed MicroRNAs in Acquired Middle Ear Cholesteatoma
    6
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    medsci.org/v15p1547.htm
  14. www.biorxiv.org www.biorxiv.org
    Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody
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    biorxiv.org/content/10.64898/2026.01.06.697868v1
  15. www.biorxiv.org www.biorxiv.org
    Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures
    2
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    biorxiv.org/content/10.64898/2026.01.05.697808v1
  16. 54.241.53.176 54.241.53.176
    lucero-et-al-2026-cardiomyocyte--arrestins-mediate-inflammation-and-cgas-sting-activation-in-cvb3-viral-myocarditis-html.html
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  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of Drosophila melanogaster TRPA1 Isoforms by Citronellal and Menthol
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8541009/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Characterization of the Drosophila Adult Hematopoietic System Reveals a Rare Cell Population With Differentiation and Proliferation Potential
    14
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    pmc.ncbi.nlm.nih.gov/articles/PMC8550105/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CK1α protects WAVE from degradation to regulate cell shape and motility in the immune response
    7
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    pmc.ncbi.nlm.nih.gov/articles/PMC8714073/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a new allele of O-fucosyltransferase 1 involved in Drosophila intestinal stem cell regulation
    8
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    pmc.ncbi.nlm.nih.gov/articles/PMC8576262/
  21. link.springer.com link.springer.com
    Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models
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    link.springer.com/article/10.1186/s13024-025-00919-9
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC8527774/
  23. www.science.org www.science.org
    Structural insights into the activation mechanism of the human metabolite receptor HCAR1
    1
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    science.org/doi/10.1126/scisignal.adw1483
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering of Candida parapsilosis induced immune response in Drosophila melanogaster
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8477938/
  25. www.nature.com www.nature.com
    Correlation between statin use and 30 day mortality in patients with acute kidney injury after intracerebral hemorrhage: a retrospective analysis
    1
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    nature.com/articles/s41598-025-34820-8
  26. www.nature.com www.nature.com
    Machine learning-based multimodal biomarkers enable accurate diagnosis and early detection of pancreatic ductal adenocarcinoma
    3
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    nature.com/articles/s41598-025-29548-4
  27. www.nature.com www.nature.com
    Prediction of impulse control disorders in Parkinson’s disease through a longitudinal machine learning study
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    nature.com/articles/s41531-025-01248-w
  28. link.springer.com link.springer.com
    Obstructive sleep apnea is more closely associated with bilateral primary aldosteronism than unilateral primary aldosteronism
    1
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    link.springer.com/article/10.1007/s40618-025-02710-5
  29. 54.241.53.176 54.241.53.176
    takahashi-et-al-2026-testosterone-deficiency-synergistically-exacerbates-fructose-induced-hepatic-steatosis-through-gut-html.html
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  30. link.springer.com link.springer.com
    Primary Human Reactive Microglia Display Mitochondrial Dysfunction and Metabolic Imbalance Upon Lipopolysaccharide Exposure
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    link.springer.com/article/10.1007/s11064-025-04647-w
  31. link.springer.com link.springer.com
    FBXW7 Inhibited M2 Macrophage Polarization in Endometrial Cancer by Reducing CCL2 Secretion Through Ubiquitination of MYBL2 Subtitle: The Role of FBXW7 on M2 Macrophage Polarization in EC
    18
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    link.springer.com/article/10.1007/s10528-025-11309-7
  32. link.springer.com link.springer.com
    Psychological stress and functional ovarian suppression in women with PCOM: an observational study of FHA-like neuroendocrine phenotypes
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    link.springer.com/article/10.1007/s00737-025-01657-z
  33. human.libretexts.org human.libretexts.org
    10.5: Mesoamerica
    1
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    human.libretexts.org/Bookshelves/History/World_History/Book:_World_History_-_Cultures_States_and_Societies_to_1500_(Berger_et_al.)/10:_The_Americas/10.05:_Mesoamerica
  34. www.whatsbetter.today www.whatsbetter.today
    Welcome to the Resistance
    4
    1. John317Michael 10 Jan 2026
      p.s. Want the visual map? You'll find a full FieldNote Sketch Summary of this inside the 'hidden' layer. Click this highlight to see the synthesis, share it with someone you know needs it and save a copy for yourself.

      You made it to the end. Here is the map of the territory we just covered. FieldNote Sketch Summary - Welcome to the Resistance Save it, share it, or keep it as a reminder that the Resistance is just proof that you’re onto something big.

      SketchNote BigPicture VisualSummary
    2. John317Michael 10 Jan 2026
      The Override Protocol You cannot out-argue the loop; you must overwrite it with Source Code.

      This is the pivot. Everything changes when we spot the lie. If you're stuck here, use the counter-measure - it seems to easy to fix it, but it works!

      NewLoops
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    whatsbetter.today/welcome-to-the-resistance/
  35. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 12: Order of execution of a Query
    6
    1. weijian.duan 10 Jan 2026
      7. ORDER BY If an order is specified by the ORDER BY clause, the rows are then sorted by the specified data in either ascending or descending order. Since all the expressions in the SELECT part of the query have been computed, you can reference aliases in this clause. 8. LIMIT / OFFSET Finally, the rows that fall outside the range specified by the LIMIT and OFFSET are discarded, leaving the final set of rows to be returned from the query.

      最后先 order by 再 limit / offset

    2. weijian.duan 10 Jan 2026
      5. SELECT Any expressions in the SELECT part of the query are finally computed. 6. DISTINCT Of the remaining rows, rows with duplicate values in the column marked as DISTINCT will be discarded.

      接下来先 select 再 distinct

    3. weijian.duan 10 Jan 2026
      If the query has a GROUP BY clause, then the constraints in the HAVING clause are then applied to the grouped rows, discard the grouped rows that don't satisfy the constraint. Like the WHERE clause, aliases are also not accessible from this step in most databases.

      接下来是 having，进一步过滤 group by 之后的结果。

      having 可以拿到聚合函数的值，但是不能使用 select 之后的别名。

    4. weijian.duan 10 Jan 2026
      As a result of the grouping, there will only be as many rows as there are unique values in that column. Implicitly, this means that you should only need to use this when you have aggregate functions in your query.

      接下来是 group by，只有用聚合函数的时候才需要使用 group by

    5. weijian.duan 10 Jan 2026
      Each of the constraints can only access columns directly from the tables requested in the FROM clause. Aliases in the SELECT part of the query are not accessible in most databases since they may include expressions dependent on parts of the query that have not yet executed.

      第一道执行的是 where 语句，只能获取到 from 语句里得到的列，select 里的别名获取不到

    6. weijian.duan 10 Jan 2026
      1. FROM and JOINs The FROM clause, and subsequent JOINs are first executed to determine the total working set of data that is being queried. This includes subqueries in this clause, and can cause temporary tables to be created under the hood containing all the columns and rows of the tables being joined.

      from 和 join 第一个被执行，用来确定 working data set

      如果有子查询的话会执行

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    sqlbolt.com/lesson/select_queries_order_of_execution
  36. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 11: Queries with aggregates (Pt. 2)
    1
    1. weijian.duan 10 Jan 2026
      Luckily, SQL allows us to do this by adding an additional HAVING clause which is used specifically with the GROUP BY clause to allow us to filter grouped rows from the result set.

      HAVING 语句是用来 filter group by 之后的结果

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    sqlbolt.com/lesson/select_queries_with_aggregates_pt_2
  37. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 10: Queries with aggregates (Pt. 1)
    3
    1. weijian.duan 10 Jan 2026
      COUNT(*), COUNT(column) A common function used to counts the number of rows in the group if no column name is specified. Otherwise, count the number of rows in the group with non-NULL values in the specified column.

      count 组内的数量，* 是所有，指定了列就是 non-NULL 的行

    2. weijian.duan 10 Jan 2026
      Without a specified grouping, each aggregate function is going to run on the whole set of result rows and return a single value.

      如果不带 grouping 的话，就是在整个表上计算，返回一个结果

    3. weijian.duan 10 Jan 2026
      In addition to the simple expressions that we introduced last lesson, SQL also supports the use of aggregate expressions (or functions) that allow you to summarize information about a group of rows of data.

      aggregation 是聚合一系列的行

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    sqlbolt.com/lesson/select_queries_with_aggregates
  38. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 8: A short note on NULLs
    1
    1. weijian.duan 10 Jan 2026
      Sometimes, it's also not possible to avoid NULL values, as we saw in the last lesson when outer-joining two tables with asymmetric data.

      有时候 null 是不可避免的，比如 join 的时候两张表的 asymmetric

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    sqlbolt.com/lesson/select_queries_with_nulls
  39. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 4: Filtering and sorting Query results
    3
    1. weijian.duan 10 Jan 2026
      In such cases, SQL provides a convenient way to discard rows that have a duplicate column value by using the DISTINCT keyword.

      distinct the combination or the first following column?

      answer: the combination

    2. weijian.duan 10 Jan 2026
      Another clause which is commonly used with the ORDER BY clause are the LIMIT and OFFSET clauses, which are a useful optimization to indicate to the database the subset of the results you care about. The LIMIT will reduce the number of rows to return, and the optional OFFSET will specify where to begin counting the number rows from.

      limit 限制 return 的行数 offset 制定从哪开始 count row

      offset 从 1 开始：limit 1 offset 1 返回第二个

    3. weijian.duan 10 Jan 2026
      When an ORDER BY clause is specified, each row is sorted alpha-numerically based on the specified column's value. In some databases, you can also specify a collation to better sort data containing international text.

      by default it's sorted alpha-numerically

      some db provide collation for better sorting for i18n text, but what?

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    sqlbolt.com/lesson/filtering_sorting_query_results
  40. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 7: OUTER JOINs
    3
    1. weijian.duan 10 Jan 2026
      Some of the buildings are new, so they don't have any employees in them yet, but we need to find some information about them regardless.

      this is an example of growing independently:

      new building can be without employees

    2. weijian.duan 10 Jan 2026
      You might see queries with these joins written as LEFT OUTER JOIN, RIGHT OUTER JOIN, or FULL OUTER JOIN, but the OUTER keyword is really kept for SQL-92 compatibility and these queries are simply equivalent to LEFT JOIN, RIGHT JOIN, and FULL JOIN respectively.

      outer 关键字是和 SQL-92 兼容，等同于不写

    3. weijian.duan 10 Jan 2026
      When joining table A to table B, a LEFT JOIN simply includes rows from A regardless of whether a matching row is found in B. The RIGHT JOIN is the same, but reversed, keeping rows in B regardless of whether a match is found in A. Finally, a FULL JOIN simply means that rows from both tables are kept, regardless of whether a matching row exists in the other table.

      left join right join full join

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    sqlbolt.com/lesson/select_queries_with_outer_joins
  41. www.kennedy-center.org www.kennedy-center.org
    What is Arts Integration?
    2
    1. katewillner 10 Jan 2026
      For example, the arts can connect to school concerns such as character education/bullying, collaboration, habits of mind, or multiple intelligences.

      I love that the arts can be used to describe various topics!!

    2. katewillner 10 Jan 2026
      By their nature, the arts engage students in learning through observing, listening, and moving and offer learners various ways to acquire information and act on it to build understanding

      This is an amazing idea that arts can provide to us in the classroom. It is so awesome that these skills are all used to help students gain a better understanding.

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    kennedy-center.org/education/resources-for-educators/classroom-resources/articles-and-how-tos/articles/collections/arts-integration-resources/what-is-arts-integration/
  42. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 6: Multi-table queries with JOINs
    4
    1. weijian.duan 10 Jan 2026
      You might see queries where the INNER JOIN is written simply as a JOIN. These two are equivalent, but we will continue to refer to these joins as inner-joins because they make the query easier to read once you start using other types of joins,

      inner join is join

    3. weijian.duan 10 Jan 2026
      and allows for data in the database to grow independently of each other (ie. Types of car engines can grow independent of each type of car). As a trade-off, queries get slightly more complex since they have to be able to find data from different parts of the database, and performance issues can arise when working with many large tables.

      normalization pros and cons

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    sqlbolt.com/lesson/select_queries_with_joins
  43. www.scientificamerican.com www.scientificamerican.com
    Stop Using Phony Science to Justify Transphobia
    8
    1. julietterusin 10 Jan 2026
      June 13, 2019
      1. This article was written in 2019 in June. The context of this is important because it was written during pride month when maybe the trans community was getting more attention (positive and negative) than usual and the author wrote this article to speak up.
    2. julietterusin 10 Jan 2026
      and reflects the views of the author
      1. The author is Simone D Sun. This line shows that they are very passionate about what they are writing about and all of the writing is based around their research and written in their perspective
    3. julietterusin 10 Jan 2026
      After the primordium forms, SRY—a gene on the Y chromosome discovered in 1990, thanks to the participation of intersex XX males and XY females—might be activated.*
      1. this line speaks to the genre because the genre is scientific. The author uses a lot of research, quotes experts, and uses scientific rhetoric to defend their claims
    4. julietterusin 10 Jan 2026
      The popular belief that your sex arises only from your chromosomal makeup is wrong.The truth is, your biological sex isn’t carved in stone, but a living system with the potential for change.
      1. The purpose of this speech is to help people understand that biology and chromosomes are a lot more complicated than they appear on the surface. This links science to the transgender experience
    5. julietterusin 10 Jan 2026
      Nearly everyone in middle school biology learned that if you’ve got XX chromosomes, you’re a female; if you’ve got XY, you’re a male. T
      1. This line directly reflects who the intended audience is. The author assumes that the audience will be people who have a very basic understanding of how biology and chromosomes work. She references a simple fact that "Nearly everyone.. learned" and then goes on to base her arguments around this fact.
    6. julietterusin 10 Jan 2026
      Contrary to popular belief, scientific research helps us better understand the unique and real transgender experience. Specifically, through three subjects: (1) genetics, (2) neurobiology and (3) endocrinology. So, hold onto your parts, whatever they may be. It’s time for “the talk.”
      1. This line states the subject of the article, previewing what the main points will be. It summarizes that the text will cover how scientific research relates to the transgender experience. By doing this, it will effectively rebut the misinformation that the author claims is being spread.
    7. julietterusin 10 Jan 2026
      Antiscientific sentiment bombards our politics, or so says the Intellectual Dark Web (IDW)

      3.This first line shows the exigence of the article, or what motivated the author to write this article. It essentially stemmed from groups on the internet spreading hateful, false rhetoric in order to influence the opinions of their readers. The author of this article, however, recognized the potential dangers of this, and therefore, wrote this article.

    8. mikocooper 10 Jan 2026
      The real world consequences are stacking up: the trans military ban, bathroom bills, and removal of workplace and medical discrimination protections, a 41-51 percent suicide attempt rate and targeted fatal violence .
      1. It is important to know about the time, place, and culture of which the text was written because these are real world problems that are happening right now. Its important that these hate acts stop and the suicide attempt rate goes down.
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    scientificamerican.com/blog/voices/stop-using-phony-science-to-justify-transphobia/
  44. substack.com substack.com
    Elisabeth (@frenchglimpses)
    1
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    substack.com/@frenchglimpses/note/c-197490071
  45. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 3: Queries with constraints (Pt. 2)
    6
    1. weijian.duan 10 Jan 2026
      We should note that while most database implementations are quite efficient when using these operators, full-text search is best left to dedicated libraries like Apache Lucene or Sphinx.

      数据库避免全文搜索对吗？

      Apache Lucene 和 Sphinx 是啥？

    2. weijian.duan 10 Jan 2026
      IN (…) String exists in a list col_name IN ("A", "B", "C") NOT IN (…) String does not exist in a list col_name NOT IN ("D", "E", "F")

      in and not in also for text data

    3. weijian.duan 10 Jan 2026
      _ Used anywhere in a string to match a single character (only with LIKE or NOT LIKE) col_name LIKE "AN_" (matches "AND", but not "AN")

      _ is for one character used with like, not like

    4. weijian.duan 10 Jan 2026
      % Used anywhere in a string to match a sequence of zero or more characters (only with LIKE or NOT LIKE) col_name LIKE "%AT%" (matches "AT", "ATTIC", "CAT" or even "BATS")

      used with like, not like 0 or more characters

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    sqlbolt.com/lesson/select_queries_with_constraints_pt_2
  46. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - SQL Lesson 2: Queries with constraints (Pt. 1)
    3
    1. weijian.duan 10 Jan 2026
      In addition to making the results more manageable to understand, writing clauses to constrain the set of rows returned also allows the query to run faster due to the reduction in unnecessary data being returned.

      返回的行数少了，SQL 就快了是吗？

    3. weijian.duan 10 Jan 2026
      BETWEEN … AND … Number is within range of two values (inclusive) col_name BETWEEN 1.5 AND 10.5 NOT BETWEEN … AND … Number is not within range of two values (inclusive) col_name NOT BETWEEN 1 AND 10

      between ... and ... and not between ... and ...

      used for numerical data inclusive

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    sqlbolt.com/lesson/select_queries_with_constraints
  47. steve-yegge.medium.com steve-yegge.medium.com
    The Death of the Stubborn Developer
    1
    1. johnsmith1 10 Jan 2026
      My colleagues and I at Sourcegraph are firmly in the camp that believes that you are the agent who will wrangle the task graph, above the level of the leaf nodes. We believe the wrangler will be human, not a model. We are not sitting around to wait for the research on autonomous agent

      He seems to have shifted that position over the last year (Gas Town and other efforts)

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    steve-yegge.medium.com/the-death-of-the-stubborn-developer-b5e8f78d326b
  48. sqlbolt.com sqlbolt.com
    SQLBolt - Learn SQL - Introduction to SQL
    1
    1. weijian.duan 10 Jan 2026
      And due to its simplicity, SQL databases provide safe and scalable storage for millions of websites and mobile applications.

      不太理解为什么 SQL 数据库是 safe 和 scale 的

      和存文件来比？

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    sqlbolt.com/
  49. isach.info isach.info
    Chí Phèo - Nam Cao ~ Chương 0
    2
    1. PhuongVy 10 Jan 2026
      bát cháo hành của thị Nở làm hắn suy nghĩ nhiều

      Bát cháo hành là biểu hiện của sự quan tâm giản dị nhưng có sức đánh thức phần người còn sót lại trong Chí Phèo

    2. PhuongVy 10 Jan 2026
      Tức mình hắn chửi ngay tất cả làng Vũ Ðại. Nhưng cả làng Vũ Ðại ai cũng nhủ, "Chắc nó trừ mình ra!" Không ai lên tiếng cả.

      Tiếng chửi của Chí Phèo thể hiện sự cô độc của một con người bị xã hội ruồng bỏ

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  50. good99.top good99.top
    Good99 Link Đăng Nhập Chính Thức
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