32 Matching Annotations
  1. Mar 2024
  2. Dec 2023
    1. For a flip-of-a-coin chance of staying at or below 1.5°C we have, globally, just five to eight years of current emissions before we blow our carbon budget
      • for: 1.5 Deg C target - 50/50 chance

      • comment

        • What most people don't recognize and pay attention to is 50/50 chance that is part of the 1.5 Deg C target.
        • The world is up in arms about the 1.5 Deg C target when it ONLY GIVES US A 50/50 CHANCE!
        • These are not great odds! In fact, THESE ODDS ARE TERRIBLE! What if you were given those chances in your cancer treatment? You would be concerned, wouldn't you?
        • So what would an intervention closer to 90% chance of staying under 1.5 Deg C look like? If people consider today's intervention impossible, then a 90% chance would be beyond impossible. This is the nature of the challenge we face!
    1. For a flip-of-a-coin chance of staying at or below 1.5°C we have, globally, just five to eight years of current emissions before we blow our carbon budget
      • for: do people know? - 50% chance, 1.5 Deg. C target - is still a crap shoot

      • new trailmark: do people know?

      • do people know?: 50% chance

        • the well known 1.5 Deg C. target, which currently seems almost impossible to achieve, is still a crap shoot! There is a 50% chance that if be we achieve it, we can still trigger very harmful impacts like tipping points
  3. Sep 2023
    1. Rượu vang 50 Anniversario – Minh chứng lịch sử cho sự kiêu hãnh và đam mê của nhà San Marzano

      Rượu vang 50 Anniversario – Minh chứng lịch sử cho sự kiêu hãnh và đam mê của nhà San Marzano

      Thông tin chi tiết về rượu vang 50 Anniversario San Marzano

      – Xuất xứ: Ý

      – Nhà sản xuất: San Marzano

      – Giống nho: Negroamaro, Primitivo

      – Nồng độ: 14.5%

      – Dung tích: 750ml

      – Quy cách: 6c/Thùng

      – Màu sắc: Đỏ

  4. Aug 2023
    1. 怎么选 说到怎么选的问题,首先可以看到,能够获得首批资格也代表着各自的硬实力不容小觑,四家都是优等生中的尖子生。易方达基金是首只创业板ETF的开发者,打造了易方达中概互联50ETF、中证科技50ETF等受欢迎的产品。华夏基金是目前境内权益类ETF管理规模最大的基金公司,连续16年排名行业第一,也是业内首家权益类ETF管理规模超千亿元的基金公司。工银瑞信基金同时拥有上证50、沪深300、中证500等多只宽基ETF。截至6月末,工银瑞信被动基金管理规模超450亿元,位居银行系基金公司首位;华泰柏瑞基金是国内最早涉足ETF领域的管理人之一,发行了首只跨市场ETF和首只红利主题ETF,在被动投资领域保持着十四载无差错运营的纪录。所以四家论实力而言,都属于基金公司头部序列。
    1. the series really is a is a proposal for an rd r d program aimed at as new de novo development of new societal systems 00:45:54 and it's also a way to context and a way to think about what transformation might mean so uh it is it is a long-term project you know like a 50-year 00:46:07 project this isn't we're not it would be dangerous to change society radically overnight
      • for: science-based societal transformation, whole system change, overnight change, 50 year project, radical change
      • paraphrase
        • this is not an overnight project
        • radical change would be dangerous
      • comment
        • the word "radical" is subjective here
        • how does John view the latest earth system science about the need to reach zero emissions in less than a decade and likely 6 years in order to stay within 1.5 Deg C carbon budget?
          • is that considered radical change or not?
  5. May 2023
  6. Aug 2022
  7. Mar 2022
  8. Nov 2021
    1. Le chef d'établissement réunit, au cours du premier trimestre, les responsables des listes de candidats qui ont obtenu des voix lors de l'élection des représentants de parents d'élèves au conseil d'administration, pour désigner les deux délégués titulaires et les deux délégués suppléants des parents d'élèves de chaque classe, à partir des listes qu'ils présentent à cette fin. Le chef d'établissement répartit les sièges compte tenu des suffrages obtenus lors de cette élection
  9. Oct 2021
  10. Sep 2021
    1. Author and librarian Nancy Pearl advocates the “Rule of 50.” This entails reading the first 50 pages of a book and then deciding if it is worth finishing. The Rule of 50 has an interesting feature: once you are over the age of 50, subtract your age from 100 and read that many pages. Pearl writes: “And if, at the bottom of Page 50, all you are really interested in is who marries whom, or who the murderer is, then turn to the last page and find out. If it’s not on the last page, turn to the penultimate page, or the antepenultimate page, or however far back you have to go to discover what you want to know.…When you are 51 years of age or older, subtract your age from 100, and the resulting number (which, of course, gets smaller every year) is the number of pages you should read before you can guiltlessly give up on a book.…When you turn 100, you are authorized (by the Rule of 50) to judge a book by its cover.”
  11. Aug 2021
    1. Selena habría cumplido 50 años

      En este reportaje que hace El Tiempo, hace un recuento de su vida, analizando el apego de dos culturas muy distintas, pero son vecinas y que con el paso del tiempo se han vuelto casi opuestas. La cultura latina, en ese tiempo estaba muy desvalorizada contra la cultura americana y Selena en compañía de su familia que era su misma banda instrumental llamada "Los Dinos", recorrieron Estados Unidos y México, dándose a conocer con una mezcla de ambas culturas, debido al origen de la familia de Selena que se había independizado en Texas.

  12. Jul 2021
    1. RRID:ZFIN_ZDB-GENO-100113-50

      DOI: 10.7554/eLife.35796

      Resource: (ZFIN Cat# ZDB-GENO-100113-50,RRID:ZFIN_ZDB-GENO-100113-50)

      Curator: @evieth

      SciCrunch record: RRID:ZFIN_ZDB-GENO-100113-50

      What is this?

    1. ZFIN: ZDB-GENO-100412-50

      DOI: 10.1016/j.celrep.2015.07.064

      Resource: (ZFIN Cat# ZDB-GENO-100412-50,RRID:ZFIN_ZDB-GENO-100412-50)

      Curator: @mpairish

      SciCrunch record: RRID:ZFIN_ZDB-GENO-100412-50

      What is this?

    1. ZFIN ID: ZDB-GENO-100412-50

      DOI: 10.1371/journal.pgen.1005798

      Resource: (ZFIN Cat# ZDB-GENO-100412-50,RRID:ZFIN_ZDB-GENO-100412-50)

      Curator: @mpairish

      SciCrunch record: RRID:ZFIN_ZDB-GENO-100412-50

      What is this?

  13. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 3.9

      AssayResultAssertion: Indeterminate

      StandardErrorMean: 0.04

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.3073G>A p.(Ala1025Thr)

    1. Source Data

      AssayResult: 56.67

      AssayResultAssertion: Not reported

      ReplicateCount: 4

      StandardErrorMean: 12.4

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 21.79

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardDeviation: 1.84

      StandardErrorMean: 1.3

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.3209T>C p.(L1070P)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 0.2

      AssayResultAssertion: Abnormal

      ReplicateCount: 25

      StandardErrorMean: 0.2

      Comment: This variant had loss of function of peak current (<10% of wildtype), therefore it was considered abnormal (in vitro features consistent with Brugada Syndrome Type 1). (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.4140C>A p.(Asn1380Lys)

  14. Feb 2021
    1. Supplemental material

      AssayResult: 69

      AssayResultAssertion: Normal

      Comment: See Table S2 for details

    2. Supplemental material

      AssayResult: 7.1

      AssayResultAssertion: Abnormal

      Comment: See Table S2 for details

    3. We analysed a total of 82 blood samples derived from 77 individuals (online supplemental table 3). These 77 individuals corresponded either to new index cases suspected to harbour a pathogenic TP53 variant or to relatives of index cases harbouring TP53 variants.

      HGVS: NM_000546.5:c.904G>A p.(Gly302Arg)

    1. bird counts across the United States have fallen a staggering 29 percent in the last 50 years

      29% in 50 years? That means in the next 50 years half of the bird population could decrease!

  15. Sep 2020
  16. Mar 2018
    1. Home change would have to be made in the duration of the Parliaments of the local systems, and it was thought desirable that the term of existence of the General Legislature should be longer than any that could possibly be adopted for the local bodies.

      §.50 of the Constitution Act, 1867.

    2. What was desired was that elections and dissolutions of Parliament should take place with sufficient frequency to ensure that the representatives should truly represent the people.

      §.50 of the Constitution Act, 1867.

    3. It was also proposed that the duration of Parliament should be extended from four to five years. The reason for adopting this coarse was that under our present system Parliaments seldom lasted longer than three years. In England where their legal duration was seven years, it was found, on an examination of the records of the last sixty or seventy years, that the average length of each Parliament was only a trifle over four years.

      §.50 of the Constitution Act, 1867.