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    Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13110130/
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    The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation
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    Loss of Gαq reshapes fibroblast traits and drives tumor-stroma remodeling in oral cancer progression
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    Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects
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    PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy
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    A conserved hormonal signalling–H2A.Z axis rapidly reorganizes 3D chromatin interactions in adipocyte thermogenesis
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    Genoarchitecture and input–output organization of the mouse basal ganglia and thalamic parafascicular nucleus
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    A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines
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    Early fibrotic niches establish tumour-permissive microenvironments
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    Cell-type-targeted mitochondrial transplantation rescues cell degeneration
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    Mapping convergent regulators of melanoma drug resistance by PerturbFate
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    Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers
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    The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport
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    Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis
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    Diverse paths to broadly neutralizing antibody escape among HIV-1 strains
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    Bridging continuous and discrete evolution through a controllable, hypermutagenic phage-bacteria system
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    The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress
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    A synaptic mechanism for encoding the learned value of action-derived safety
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    Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation
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    High-speed multiplexed DNA-PAINT imaging of nuclear organization using an expanded sequence repertoire
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    Technical and biological sources of noise confound multiplexed enhancer AAV screening
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    PEX11 mediates intralumenal vesicle formation in peroxisomes
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    The vault associates with membranes in situ
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    Phage-assisted evolution of allosteric protein switches
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    Efficient genome editing with chimeric oligonucleotide-directed editing
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    Thyrotropin-releasing hormone neurons of different hypothalamic nuclei increase energy expenditure
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    Disruption of the SAGA CORE triggers collateral degradation of KAT2A
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    CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic
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    SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity
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    Chemotherapy-induced activation of caspase-1 and IL-1α release by cancer cells remotely skews myelopoiesis to drive pro tumorigenic systemic neutrophil-dominant inflammation
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    MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes
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    Inhibition of circulating glycocholic acid-regulated signaling potentiates immune checkpoint therapy in colorectal cancer
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    Comprehensive CRISPR/Cas9-based mutagenesis identifies single-amino acid substitutions that abrogate SPEN function in X inactivation
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    Immune-induced TCR-like antibodies regulate specific T cell response in mice
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    Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors
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    A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development
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    Nicotinamide N-methyltransferase as a therapeutic target in taxane-resistant castration-resistant prostate cancer
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    SMARCA4 activation engages FOSL1 to drive enhancer reprogramming and tumorigenic phenotypes in SMARCA4-deficient LUAD cells
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    Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors
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    Surface CD81 supports leukemia stem cell function and reveals a therapeutic vulnerability in acute myeloid leukemia
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    The Gdf15-xenobiotic receptor axis shapes NK cell maladaptation predicting cold tumors under environmental stress
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    Bioengineered iPSC-derived human macrophages with increased angiotensin-converting enzyme (ACE) expression suppress solid tumor growth
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    Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance
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    Multimodal optical imaging combining voltage-sensitive dye ElectroFluor630 with genetically encoded calcium, glutamate, or voltage indicators
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    Suppression of PP2A-B56α drives EMT in EGFR mutant non-small cell lung cancer
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    Vertebral BMSC-EVs under estrogen deficiency drive senescence-related mitochondrial dysfunction in endplate chondrocytes via MRPL1 mRNA delivery
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    TopBP1 orchestrates PU.1–IRF8 transcriptional programming of dendritic cell differentiation and Flt3L-driven tumor immunity
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    Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation
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    Acidosis Regulates Microtubule Dynamics via the β1 Integrin/RhoA/CRMP‑2 Axis
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    CD38 overexpression drives glioblastoma progression via L1CAM/ICAM1/JAK-STAT-Driven tumor microenvironment rewiring
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    Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1
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    A CXCR4 targeting peptide delivered by silica nanoparticles eliminates migrating cancer stem cells in pancreatic ductal adenocarcinoma
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    Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility
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    Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer
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    BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells
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    N-Glycosylation of AXL Receptor Tyrosine Kinase Regulates Its Stability, Phosphorylation, and Oncogenic Function
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    Potassium suppresses allosteric activation of ZAP-70-dependent T cell receptor signaling
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    JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes
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    Mycobacterium tuberculosis subverts macrophage-mediated defense through exploitation of the Zn transporter ZIP8
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    Distinct 2-phenylimidazo[1,2-a]pyridine derivatives that inhibit breast cancer cell proliferation identified as AHR ligands
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    Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons
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    Prenatal exposure to particulate matter impairs offspring behavior via hippocampal NMDA receptor reduction: An in vivo and ex vivo study
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    Achieving cell-type specific transduction with adeno-associated viral vectors in pigeons
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    Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity
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    The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis
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    HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication
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    SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma
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    Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14
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    Targeting SARS-CoV-2 main protease (3CLpro) with Paeonia-derived phytochemicals
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    The MIF-CD74 axis drives colorectal cancer via glycolytic reprogramming and is targeted by a novel small-molecule inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC13103017/
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    Autophagy-Lysosomal Axis Stimulation by Beta-Hydroxybutyrate in Astrocytes
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    The pseudokinase domain PK1 of UNC-89/obscurin is required for mitochondrial morphology and function in C. elegans
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    From 2D to 3D Bioprinted In Vitro Breast Cancer Model: A Comparative Study of Proliferation, Tissue Structure, and mTOR Signaling
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    Inducible T Cell Costimulator Ligand and Inducible T Cell Costimulator Stratification Identify Dichotomous Tumor Microenvironment and Guide Chemo‐Immunotherapy in Small Cell Lung Cancer
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    Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus
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    Extracellular Vesicle‐Associated IL4 Displays Enhanced Anti‐Inflammatory Properties in Microglial Cells
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  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A RiboCancer cell line panel reveals that CLL‐associated Rps15 mutations translationally rewire transcription through codon‐specific tRNA accommodation defects
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    pmc.ncbi.nlm.nih.gov/articles/PMC13239286/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PVT1‐104aa derived from the 8q24 gene desert promotes colorectal cancer tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13062635/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Monoclonal Antibodies Accessing the Cytosol of Living Cells and Binding to Polo‐Like Kinase 1 Interdomain Linker Affect Mitotic Behavior
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    pmc.ncbi.nlm.nih.gov/articles/PMC13127698/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Preclinical Effects and Mechanisms of Biofield Therapy on Pancreatic Cancer Cell Growth and Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13071467/
  91. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates
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    pmc.ncbi.nlm.nih.gov/articles/PMC13090027/
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms
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    pmc.ncbi.nlm.nih.gov/articles/PMC13246000/
  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrinsic coordination of dynamic molecular signatures shape the human prefrontal cortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC13192659/
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAD54L promotes nascent DNA degradation and radial chromosome formation in FANC-deficient cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13192876/
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cp36 serine recombinase as a new tool for zebrafish transgenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13192844/
  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Compartmentalized glycolysis powers ATP production in primary cilia and engages mitochondria via the phosphoenolpyruvate cycle
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    pmc.ncbi.nlm.nih.gov/articles/PMC13192855/