10 Matching Annotations
  1. May 2019
    1. in February, 1977, Searle's law firm, Sidley & Austin, offered Skinner a job, which he accepted, recusing himself from the case

      The company being sued for the cover up of the negative side effects of aspartame hires the lawyer that represented the FDA thus resulting in the case never making it to trial.

    2. n January 1977, formally requested that a grand jury be convened to investigate whether indictments should be filed against Searle for knowingly misrepresenting findings and "concealing material facts and making false statements" in aspartame safety tests (the first time in the FDA's history that they request a criminal investigation of a manufacturer)

      Aspartame was so poorly misrepresented in the scientific research provided for its approval that it became the first case in history in which a lawsuit was brought against the manufacturer for concealing of material facts and false statements.

    1. elevated cortisol and gut dysbiosis via interactions with different biogenic amine may also have additional impact to modulate neuronal signaling lead to neurobiological impairments

      In summary aspartame increases the fire of neurotransmitters, increases heart rate and and blood pressure, and imbalances gut bacteria.

    2. aspartame metabolite; mainly Phy and its interaction with neurotransmitter and aspartic acid by acting as excitatory neurotransmitter causes this pattern of impairments

      Aspartame alters the chemical composition of the brain and excites neurotransmitters.

    1. examination showed fetal capillaries with condensed nuclei of endothelial cells, cytotrophoblasts with condensed fragmented nuclei and vacuolated cytoplasm, and syncytiotrophoblasts with irregular condensed fragmented nuclei

      In summary aspartame results in the death of cells that carry nutrients and energy to the growing embryo.

    2. Damage in the placenta was detected in the form of rupture of the interhemal membrane, lysis of glycogen trophoblast cells, spongiotrophoblast cells with vacuolated cytoplasm and darkly stained nuclei.

      Aspartame caused placenta cells to rupture and behave like they had been exposed to a pathogen or virus.

    1. Results reveal that the aspartame molecule is inherently amyloidogenic, and the self-assembly of aspartame becomes a toxic trap for proteins and cells

      Aspartame inhibits the function of organs and tissues via clusters of proteins/“plaque”.

    2. Aspartame fibrils were also found to induce hemolysis, causing DNA damage resulting in both apoptosis and necrosis-mediated cell death.

      This study found that aspartame causes DNA damage and cell death.

  2. Feb 2019
    1. Why are opioids dangerous?

      If opioids are prescribed and overtaken, then your risk of becoming dependent on the drug goes up. Opioids are highly addictive.

  3. Sep 2018
    1. “The food is contaminated, but why are my portions so small?”

      This analogy stood out to me as a very effective means to explain what the author is trying to get at. The idea that regardless of how bad something is, if everyone has it and I don't, the question isn't if I should have it, it's why don't I. It's used fairly effectively here to get the point across, specifically with the idea of food, which is so necessary to us. We could even go further to draw the connection between food and technology as now completely essential to our lives that who cares if it's contaminated or dangerous, we still need it.