3 Matching Annotations
  1. Jan 2019
    1. For large-scale software systems, Van Roy believes we need to embrace a self-sufficient style of system design in which systems become self-configuring, healing, adapting, etc.. The system has components as first class entities (specified by closures), that can be manipulated through higher-order programming. Components communicate through message-passing. Named state and transactions support system configuration and maintenance. On top of this, the system itself should be designed as a set of interlocking feedback loops.

      This is aimed at System Design, from a distributed systems perspective.

  2. Jan 2014
    1. The creation and exploitation of large-scale quantitative atlases will lead to a more precise understanding of development.

      large-scale quantitative atlases lead to more precise understanding

    2. Just as comprehensive datasets of genomic sequence have revolutionalized biological discovery, large-scale quantitative measurements of gene expression and morphology will certainly be of great assistance in enabling computational embryology in the future. Such datasets will form the essential basis for systems level, computational models of molecular pathways and how gene expression concentrations and interactions alter to drive changes in cell shape, movement, connection, and differentiation. In this review, we discuss the strategies and methods used to generate such datasets.