8 Matching Annotations
  1. Sep 2021
    1. Such scaled-up communication and collaboration processes would also require meta-design principles to collaboratively construct the required design rationale, media and environments [23].
    2. Etzioni astutely observed that all communities have a serious defect: they exclude. To prevent communities from over-excluding, they should be able to maintain some limitations on membership, yet at the same time greatly restrict the criteria that communities may use to enforce such exclusivity. He therefore proposed the idea of “megalogues”: society-wide dialogues that link many community dialogues into one, often nation-wide conversation [7].
  2. May 2021
  3. Oct 2020
  4. May 2020
  5. Jan 2019
    1. For large-scale software systems, Van Roy believes we need to embrace a self-sufficient style of system design in which systems become self-configuring, healing, adapting, etc.. The system has components as first class entities (specified by closures), that can be manipulated through higher-order programming. Components communicate through message-passing. Named state and transactions support system configuration and maintenance. On top of this, the system itself should be designed as a set of interlocking feedback loops.

      This is aimed at System Design, from a distributed systems perspective.

  6. Jan 2014
    1. The creation and exploitation of large-scale quantitative atlases will lead to a more precise understanding of development.

      large-scale quantitative atlases lead to more precise understanding

    2. Just as comprehensive datasets of genomic sequence have revolutionalized biological discovery, large-scale quantitative measurements of gene expression and morphology will certainly be of great assistance in enabling computational embryology in the future. Such datasets will form the essential basis for systems level, computational models of molecular pathways and how gene expression concentrations and interactions alter to drive changes in cell shape, movement, connection, and differentiation. In this review, we discuss the strategies and methods used to generate such datasets.