13 Matching Annotations
  1. Aug 2024
    1. Degradation ofecosystem services could be significantly slowed down or even reversed if the role ofbiodiversity and its full contribution to economic production were an integrated part ofdecisions made by governmental entities, companies, and other stakeholders (Paul et al2020)20

      for - biodiversity - impact of monoculture diet

      biodiversity - impact of monoculture diet - FAO study done before 2000 and often cited shows that 75% of the global diet comes from 12 plant and 5 animal food sources

      to - stats - progress trap - monoculture - table of 12 plant and 5 animal species that make up 75% of world's diet - https://hyp.is/iznepFWoEe-umbNyOGVqrg/thefuturemarket.com/biodiversity

  2. Jul 2024
    1. metabolic syndrome

      for - health - insulin resistance - metabolic syndrome

      health - insulin resistance - metabolic syndrome - When your mitochondria doesn't work, it results in insulin resistance - Metabolic syndrome includes an enormous variety of the major diseases afflicting modernity - up to 75% of the diseases that affect modern humans and - up to 75% of today's health care costs - and includes - type 2 diabetes - hypertension - dyslipidemia - cardiovascular disease - cancer - dementia - fatty liver disease - pollycystic ovarian disease - (he didn't include strokes here but he mentions throughout his talk)

  3. Aug 2022
    1. Dowdy, D. (2021, September 21). On the J&J booster news, keep in mind: 1. Median follow-up since 2nd dose was just 36 days, 2. Efficacy vs moderate COVID was 75% globally, and 3. Total number of cases in the US was 15. Please don’t take this to mean that a 2nd dose provides long-term increase in protection. Https://t.co/RnqDNBmwuD [Tweet]. @davidwdowdy. https://twitter.com/davidwdowdy/status/1440323242942554122

  4. Jan 2022
  5. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 4.9

      AssayResultAssertion: Normal

      StandardErrorMean: 0.93

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.3494C>T p.(Ser1165Leu)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 51.9

      AssayResultAssertion: Indeterminate

      ReplicateCount: 12

      StandardErrorMean: 18.8

      Comment: This variant had a mild loss of function in peak current (50-75% of wildtype). It had unmeasured late current, but has been previously reported to have high late current (GOF feature). Therefore it was considered to meet neither the abnormal or normal functional parameter. (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.5350G>A p.(Glu1784Lys)

  6. May 2015
    1. SCENE I. A desert place.

      SCENE I. A desert place. at 75..99

    2. SCENE I. A desert place.

      SCENE I. A desert place. at 75..99

    3. SCENE I. A desert place.

      SCENE I. A desert place. at 75..99