10,000 Matching Annotations
  1. Aug 2025
  2. elifesciences.org elifesciences.org
    Transcriptional dynamics uncover the role of BNIP3 in mitophagy during muscle remodeling in Drosophila
    4
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    elifesciences.org/articles/105834
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A pair of dopaminergic neurons DAN-c1 mediate Drosophila larval aversive olfactory learning through D2-like receptors
    5
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    pmc.ncbi.nlm.nih.gov/articles/PMC12349901/
  4. elifesciences.org elifesciences.org
    Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome
    3
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    elifesciences.org/reviewed-preprints/104720
  5. elifesciences.org elifesciences.org
    Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
    21
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    elifesciences.org/articles/101918
  6. elifesciences.org elifesciences.org
    Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms
    1
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    elifesciences.org/articles/103260
  7. Jul 2025
  8. elifesciences.org elifesciences.org
    Archaea: Exploring surface structures
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    elifesciences.org/articles/96485
  9. elifesciences.org elifesciences.org
    Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans
    1
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    elifesciences.org/reviewed-preprints/103729v2
  10. elifesciences.org elifesciences.org
    The influence of nucleus accumbens shell D1 and D2 neurons on outcome-specific Pavlovian instrumental transfer
    4
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    elifesciences.org/reviewed-preprints/107566
  11. elifesciences.org elifesciences.org
    Conduction pathway for potassium through the E. coli pump KdpFABC
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    elifesciences.org/reviewed-preprints/107397
  12. elifesciences.org elifesciences.org
    Single neurons detect spatiotemporal activity transitions through STP and EI imbalance
    3
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    elifesciences.org/reviewed-preprints/107708
  13. elifesciences.org elifesciences.org
    Layilin regulates Treg motility and suppressive capacity in skin
    4
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    elifesciences.org/articles/105277
  14. elifesciences.org elifesciences.org
    Neural circuit mechanisms for steering control in walking Drosophila
    16
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    elifesciences.org/articles/102230
  15. elifesciences.org elifesciences.org
    Photoreceptor loss does not recruit neutrophils despite strong microglial activation
    3
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    elifesciences.org/articles/98662
  16. elifesciences.org elifesciences.org
    Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
    15
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    elifesciences.org/articles/106469
  17. elifesciences.org elifesciences.org
    Divergent folding-mediated epistasis among unstable membrane protein variants
    1
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    elifesciences.org/articles/92406
  18. elifesciences.org elifesciences.org
    tRNA genes rapidly change in evolution to meet novel translational demands
    1
    1. Kevingomezgg 19 Jul 2025
      We then evolved the deletion strain and observed that the genetic adaptation was recurrently based on a strategic mutation that changed the anticodon of other tRNA genes to match that of the deleted one.

      This is a key finding. It highlights how a single point mutation in an anticodon can functionally replace a lost tRNA, emphasizing the adaptability of the translational machinery.

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    elifesciences.org/articles/01339
  19. elifesciences.org elifesciences.org
    Distinct dendritic Ca2+ spike forms produce opposing input-output transformations in rat CA3 pyramidal cells
    1
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    elifesciences.org/articles/74493
  20. elifesciences.org elifesciences.org
    POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons
    7
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    elifesciences.org/articles/100722
  21. elifesciences.org elifesciences.org
    G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway
    1
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    elifesciences.org/reviewed-preprints/107841
  22. elifesciences.org elifesciences.org
    Striatal Crosstalk Between Dopamine and Serotonin Systems
    2
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    elifesciences.org/reviewed-preprints/107252
  23. elifesciences.org elifesciences.org
    The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas
    1
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    elifesciences.org/reviewed-preprints/106840
  24. elifesciences.org elifesciences.org
    Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes
    2
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    elifesciences.org/articles/106728
  25. elifesciences.org elifesciences.org
    Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
    3
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    elifesciences.org/articles/67170
  26. elifesciences.org elifesciences.org
    Cnidarian hair cell development illuminates an ancient role for the class IV POU transcription factor in defining mechanoreceptor identity
    1
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    elifesciences.org/articles/74336
  27. elifesciences.org elifesciences.org
    Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
    1
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    elifesciences.org/articles/71420
  28. elifesciences.org elifesciences.org
    Multifaceted role of galanin in brain excitability
    1
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    elifesciences.org/articles/98634
  29. elifesciences.org elifesciences.org
    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
    1
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    elifesciences.org/articles/101984
  30. elifesciences.org elifesciences.org
    PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
    29
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    elifesciences.org/reviewed-preprints/107556
  31. elifesciences.org elifesciences.org
    Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing
    3
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    elifesciences.org/reviewed-preprints/107298
  32. elifesciences.org elifesciences.org
    Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes
    9
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    elifesciences.org/articles/104048
  33. elifesciences.org elifesciences.org
    Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells
    3
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    elifesciences.org/reviewed-preprints/106550
  34. elifesciences.org elifesciences.org
    Ribozyme-catalysed RNA synthesis using triplet building blocks
    5
    1. Kevingomezgg 15 Jul 2025
      t5+1 could assemble these into αβ+ and γδε+ fragments, guided only by partially overlapping ‘−’ strands (Figure 6b, Figure 6—figure supplement 1). Through non-covalent association (Vaish et al., 2003; Mutschler et al., 2015), the ribozyme-synthesised αβ+ and γδε+ fragments spontaneously reconstituted a new catalytically active triplet polymerase ribozyme (with in vitro transcribed type 1 RNA)

      The ribozyme can build copies of parts of itself and put them together like puzzle pieces to regenerate function. That’s basically modular self-replication, which I thought only synthetic biology was capable of.

    2. Kevingomezgg 15 Jul 2025
      RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs. To address this apparent paradox, we have re-examined the building blocks used for RNA replication.

      This blew my mind, RNA has to fold into specific shapes to work like a ribozyme, but those same shapes make it harder to copy. It’s like building a key that locks itself.

    3. abrasiliano 12 Jul 2025
      Although still inefficient, the fact that the nascent activity of the 0core ribozyme could already copy templates that had confounded an established RPR encouraged us to continue to seek improved triplet polymerase ribozymes to leverage this substrate behaviour.

      This early success gave the researchers a good reason to keep pushing forward, since it hinted that triplet-based RNA replication might help overcome a key obstacle in the field.

    4. abrasiliano 12 Jul 2025
      he strong inhibitory role of this central feature of RNA leads to an antagonism between the degree to which an RNA sequence is able to fold into a defined three-dimensional structure to encode function (such as catalysis) and the ease with which it can be replicated (Boza et al., 2014).

      This "structure vs. replication" tradeoff is a bigger deal because it may have made it harder for life to get started using RNA as both the genetic material and the machinery for replication.

    5. abrasiliano 12 Jul 2025
      Yet, although ribozymes can be made to copy straight RNA templates this way, folded RNA templates – including the replicase ribozyme itself – impede copying. In this apparent paradox, a ribozyme needs to fold to copy RNA, but when folded, is itself copied poorly. Here, Attwater et al. wondered if choosing different building blocks might overcome this contradiction.

      I think this presents a contradiction, that the structure hat enables function also hinders duplication. However, the sentence introduces a key barrier that the research seeks to address.

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    elifesciences.org/articles/35255
  35. elifesciences.org elifesciences.org
    The BRAIN Initiative data-sharing ecosystem: Characteristics, challenges, benefits, and opportunities
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    elifesciences.org/articles/94000
  36. elifesciences.org elifesciences.org
    Endogenous oscillatory rhythms and interactive contingencies jointly influence infant attention during early infant-caregiver interaction
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    elifesciences.org/articles/88775
  37. elifesciences.org elifesciences.org
    Transcranial focused ultrasound to human rIFG improves response inhibition through modulation of the P300 onset latency
    1
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    elifesciences.org/articles/86190
  38. elifesciences.org elifesciences.org
    Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans
    2
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    elifesciences.org/articles/85728
  39. elifesciences.org elifesciences.org
    Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1
    1
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    elifesciences.org/articles/85599
  40. elifesciences.org elifesciences.org
    Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner
    1
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    elifesciences.org/articles/78517
  41. elifesciences.org elifesciences.org
    Structural mechanism of strand exchange by the RAD51 filament
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    elifesciences.org/reviewed-preprints/107114v1
  42. elifesciences.org elifesciences.org
    Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5
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    elifesciences.org/reviewed-preprints/107037v1
  43. elifesciences.org elifesciences.org
    Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers
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    elifesciences.org/reviewed-preprints/106979v1
  44. elifesciences.org elifesciences.org
    Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection
    1
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    elifesciences.org/reviewed-preprints/106621v1
  45. elifesciences.org elifesciences.org
    Calibration and validation strategy for electromechanical cardiac digital twins
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    elifesciences.org/reviewed-preprints/106555v1
  46. elifesciences.org elifesciences.org
    CHROMAS: A Computational Pipeline to Track Chromatophores and Analyze their Dynamics
    9
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    elifesciences.org/reviewed-preprints/106509v1
  47. elifesciences.org elifesciences.org
    Coenzyme A governs proinflammatory macrophage metabolism
    2
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    elifesciences.org/reviewed-preprints/106473
  48. elifesciences.org elifesciences.org
    CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teeth
    9
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    elifesciences.org/articles/105153
  49. elifesciences.org elifesciences.org
    A temporally restricted function of the dopamine receptor Dop1R2 during memory formation
    12
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    elifesciences.org/articles/99368
  50. elifesciences.org elifesciences.org
    Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs
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    elifesciences.org/reviewed-preprints/107534
  51. elifesciences.org elifesciences.org
    The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA
    1
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    elifesciences.org/articles/96414