1,054 Matching Annotations
  1. Feb 2017
    1. Over time, the provision of researcher workflows might even result in direct to consumer business models, offering either a complete solution for unaffiliated users, added value sales to users with institutional affiliations, or ultimately a complete solution.

      Interesting to ponder.

    2. Springer Nature’s sibling Digital Science is probably Elsevier’s foremost competitor in this space, albeit with a different investment and integration model.

      Springer Nature efforts.

    3. Open access advocates might be concerned about some of these directions, but my sense is that many of these scientists and librarians remain largely focused on trying to compete with, or at least influence, scientific publishing.

      Yes.

    4. One’s data and notes are stored and deposited in systems that, even if they allow ready export, are difficult if not impossible to utilize outside the original environment.

      This is why interoperability should be a key selling point.

    1. Caring about people’s feelings doesn’t make managers airy-fairy pushovers; rather, such leaders recognize their job is to help people excel. And they produce exceptional results not in spite of their compassion and kindness, but because of it.
    2. Abusive behaviour sure doesn’t spur productivity: A 2006 Florida State University study of 700 employees in a variety of different roles found that those with abusive bosses were five times more likely to purposefully slow down or make errors than their peers, and nearly six times more likely to call in sick when they actually felt fine.
  2. Jan 2017
    1. a number of studies have found that people on welfare, black Americans included, feel that people take advantage of the system and receive benefits when they should not

      Protestant work ethic shit, undermining social safety nets for all.

  3. Dec 2016
    1. Now, there is only so much survival training that is required, and there is always a little bit that is needed ongoing because it relates to your need to provide income for yourself and to get along with other people. You live in a social setting as well as a biological one. You must survive physically and you must survive socially. To do this you must develop your personal self so that you can communicate and participate with people effectively and be able to manage the simple affairs of your life. This is ongoing because even with a greater emphasis in life, you will have to develop and cultivate your personal self to accommodate this greater emphasis. Do not expect God to come and give you a great mission in life until you have the capacity for it.
    2. If you are with the world's evolution, you will comprehend what needs to be done by you individually, and you will not condemn the world for its inevitable course. There are many people who think, "I want the world to be fun for me, and I hate the world because it is not fun for me! I will not be happy until the world is fun for me!" So, you have another miserable person in the world, blaming the world for being itself. You are the architects of the next century. The results of your labors will be experienced by your offspring. That is how each generation builds for the next.
    3. eople did not come here on vacation. Vacation is when you go Home. Then you lie on the beach-if there were a beach! No, you came here to work, to experience and to contribute. That is why your stay here is so brief.If coming to the world were a holiday, you could come for hundreds of years, but it's not a holiday. If you think it's a holiday, you will feel empty because life here cannot give you what you had before. The world does not possess the reality of your Spiritual Family, and so the intimacy and integration that are absolutely natural in your former state cannot be duplicated here completely. Yes, the world can be lots of fun, but only for those who are contributing because they are enjoying their own presence in the world. The world is bringing forth the value that they have brought with them. This is entirely natural and is no sacrifice.
  4. Oct 2016
  5. Sep 2016
    1. Tim Ferriss said it best: “Being busy is a form of laziness—lazy thinking and indiscriminate action. Being busy is often used as a guise for avoiding few critically important but uncomfortable actions.”

      Working Hard

    1. and more recently, eels were important for identifying acetylcholine receptors

      Electric eels have been used as a model in the study of bioelectrogenesis, which is the study of electricity produced by living organisms. The species is of some interest to researchers, who make use of its acetylcholinesterase and adenosine triphosphate.

    2. electrical discharges resemble motor neuron activity that induces fast muscle contraction

      a brief and single electric shock(stimulus) triggers a signal (action potential) in the muscle. After an activation delay ( due to the time it takes for the signal to reach its target) a muscle contraction occurs. The muscle usually relaxes after a few milliseconds unless another contraction signal is send out before the muscle fully relaxes where the muscle contracts again. The contraction that happens after the second contraction is greater that the first because it equals the sum of the tension from both signals being greater. Each of these signals causes the specie to involuntarily twitch and lose control over motor neuron and therefore movement.

    1. The Future of the Professions: How Technology Will Transform the Work of Human Experts
    2. “The Future of Employment: How Susceptible Are Jobs to Computerisation?”
    3. It is by now close to certain that there are millions of people currently in high school and college who are fine-tuning their skills for steady-looking careers that will, following technological breakthroughs, dissipate by the time they retire.
    1. We commonly look at Ivy League institutions as the standard of higher education in America, but the truth is that the majority of the nation's workforce, innovation identity and manufacturing futures are tied to those institutions which graduate outside of the realm of high achievers from wealthy families. 
  6. Jul 2016
  7. Jun 2016
    1. The War on Stupid People

      Lots of difficult things with this text, including the title. The obsession on measurable “smarts” is an important topic and the possible measures to prevent this obsession from impacting (US) society make sense. But it’s really tricky to discuss intelligence in such ways. Part of the text reads as further essentialisation of measured intelligence. Yet it sounds clear from the possible measures described that this form of intelligence takes at least part of its meaning in a given social context.

      Maybe the deep issue with a text like this is that it’s hard to get people to shift from one consistent mindframe (paradigm, episteme) to another. More specifically, it’s hard to discuss intelligence in a context where the concept has become so loaded.

      Would have lots more to say about this from my parents’ experiences (an occupational therapist who spent a career with people labelled as having “intellectual disabilities” and a psychopedagogue who worked in “special education” with students from a low-income neighbourhood who had “learning disabilities”). Maybe later.

  8. Apr 2016
    1. “fundamentally if we want to realize the potential of human networks to change how we work then we need analytics to transform information into insight otherwise we will be drowning in a sea of content and deafened by a cacophony of voices”

      Marie Wallace's perspective on the potential of bigdata analytics, specifically analysis of human networks, in the context of creating a smarter workplace.

  9. Feb 2016
    1. Work/Life Integrity

      Definition: Work so that it produces value that is important to you in the world. Live your life (family & personal lifestyle) in a way that is consistent with the values that are important to you.

  10. Jan 2016
    1. “Don’t worry about things. Don’t push. Just do your work and you’ll survive. The important thing is to have a ball, to be joyful, to be loving and to be explosive. Out of that comes everything and you grow.”

      Quote from Ray Bradbury

  11. Dec 2015
    1. And yes, the fact that it is easier to make stuff up rather than do actual work is another lesson.

      Ideas are cheap.

    1. Zach Holman on remote work. Tech companies need to start accepting remote workers, or they're going to have more trouble finding people. To use remote workers successfully, you have to put priority on asynchronous communication for everyone. Otherwise, the remote people get left out of the loop.

  12. Nov 2015
    1. Americans actively suppress gratitude on the job, even to the point of robbing themselves of happiness. Why? It may be because in theory, no one gives away anything at work; every exchange is fundamentally economic. You don’t deliver that memo to your boss at three o’clock sharp out of the goodness of your heart, but because that is what you’re being paid to do. Your “thanks” is a paycheck. Fail to do what you’re “asked,” and you may not see another one. Tellingly, only those who earned $150,000 or more were likely to express any gratitude for their jobs, according to the Templeton survey. This hints at one of the factors that undermines gratitude at work: power and pay imbalances. In a study published in January 2012, M. Ena Inesi and colleagues found that people with power tended to believe others thanked them mainly to kiss their butts, not out of authentic feeling—and as a result of this cynicism, supervisors are themselves less likely to express gratitude.
    2. Why should anyone thank you for just doing your job? And why should you ever thank your coworkers for doing what they’re paid to do? These are common questions in American workplaces, often posed rhetorically—and sometimes with hostility.
  13. Sep 2015
    1. The girls unanimously agree that this is a constant problem in their work and they feel helpless to combat it.

      But they're okay with it...... ??? They seem to just accept the fact that these are the working conditions and it's "a part of the job"..

    1. The amazing thing here is that noticing your Stress Reaction is all you have to consciously do. The rest mostly takes care of itself. Once you notice it, you’ll automatically start to mitigate it. And you don’t necessarily have to stop the behavior completely. Some of your Stress Reaction may be helpful even if too much is hurtful. It’s useful in turbulent times to manage more closely, withdraw to reflect, and compete a little harder than usual. It helps keep you on track and focused. Just remember to pause. And notice.
  14. Aug 2015
  15. www.armchairnews.com www.armchairnews.com
    1. We care about doing what we want to do creatively. We want to be interested in it. We want it to challenge us. We want it to be difficult. We want to reinvent the stupid thing every time.

      I remind myself of this when I get stuck not wanting to do something because it appears like it has already been done, especially when it looks like it was done and it failed. The use of “we” seems particularly significant, and inspiring.

    1. We previously established coronal cross-linking of PI in such BCP micelles as a means to achieve permanent micelle stability in good solvents for both blocks

      Winnik and Manners et. al. used Karstedt's catalysts to cross-link polyisoprene in order to create micelles of varying morphologies. They were able to apply this technique for the development of noncentrosymmetric micelles.

    2. this method has been limited to the creation of centrosymmetric nanostructures

      Prior to this article, despite the usefulness of CDSA, many of the structures synthesized were centrosymmetric since growth can happen from both ends of the micelle core. This article presents the development of a method to overcome this limitation.

    3. In recent years, CDSA processes have been used to access elongated structures for a range of crystalline-coil BCPs

      After the discovery of CDSA, the synthetic strategy has been used with a range polymers including conducting, biocompatible, metal-containing, etc.

    4. In several cases, CDSA has been demonstrated to be a living process because the ends or edges of the micelles remain active to the addition of further unimer

      Previous Work: During CDSA, the crystalline core of the micelle is partially "exposed" to the solvent. When unimers are added to the micelle solution, they are able to grow on existing micelle. However, if the chemical structure of the core prevents crystallization/is not a lattice match, then micelle growth will not happen. This technique has been widely used with a variety of materials such as diblock polymers and nanotubes to create unique self-assemblies.

    5. crystallization-driven self-assembly (CDSA)

      This technique was first introduced in 2007 by Winnik and Manners et. al. where they discovered a "living" form of micellization. The term "living" in this scenario is derived from the phase "living polymerization" where monomers form long chains by continuous addition to the reactive chain ends, without termination. In the same way, certain micelles specifically those that had crystalline cores exhibited the ability to elongate when additional block copolymers are added to the micelle solution.

  16. Jul 2015
    1. Via its interaction with dynein and dynactin, HDAC6 acts as an adaptor that mediates retrograde transport of misfolded protein aggregates along microtubules (MTs) to aggresomes (14).

      
Previous study demonstrated that HDAC6 has the capacity to bind both polyubiquitinated misfolded proteins and dynein motors, thereby acting to recruit misfolded protein cargo to dynein motors for transport to aggresomes.

      Cells deficient in HDAC6 fail to clear misfolded protein aggregates from the cytoplasm, cannot form aggresomes properly, and are hypersensitive to the accumulation of misfolded proteins.

    2. An inhibitor of the deacetylase activity of HDAC6,

      This study reported the design and synthesis of a potent and selective HDAC6 inhibitor.

    3. We generated a mutant cell line HDAC6 (ZnFm-W1116A) with a mutation in the corresponding mouse HDAC6 ZnF-UBP

      In a previous work, scientists investigated whether ubiquitin chain binding affects HDAC6 activity. To generate a ubiquitin-chain binding deficient mutant of HDAC6, they mutated several residues in the BUZ finger that were predicted to make contacts with ubiquitin. It was found that W1182A point mutation markedly disrupted the ability of HDAC6 to bind free ubiquitin chains.

    4. A point mutation W1182A in the human HDAC6 ZnF-UBP disrupts binding of free Ub chains

      In a previous work, scientists investigated whether ubiquitin chain binding affects HDAC6 activity. To generate a ubiquitin-chain binding deficient mutant of HDAC6, they mutated several residues in the BUZ finger that were predicted to make contacts with ubiquitin. It was found that W1182A point mutation markedly disrupted the ability of HDAC6 to bind free ubiquitin chains.

    5. While analyzing the role of HDAC8 and HDAC3 in endosome maturation and IAV penetration

      In a previous work, the authors found the histone deacetylase 8 was required for centrosome cohesion and influenza A virus entry.

    1. The first wasat the origin of the domestication process, and thesecond was more recent during breed formationover the past several hundred years

      Previously, the DNA analysis of the genome of prehistoric wolves and dogs support the idea of a two-step domestication process. The first one was the evolution of wolves through a mutually beneficial relationship with humans, sharing food and space. The second one was the active breeding of dogs by humans in order to select dogs which were adapted to the current needs (hunting, tracking, pet).

      Furthermore, there are two main hypotheses to explain the first domestication step (http://www.americanscientist.org/issues/pub/early-canid-domestication-the-farm-fox-experiment):

      1) “Self-domestication” by the wolves: Some wolves lived in the vicinity of the camps of the nomadic hunter-gatherers to eat the garbage left by the prehistoric people. Those that were less anxious thrived and continued to follow the humans, generation after generation, and gradually the first dogs emerged from this group.

      2) The prehistoric people actively selected wolf pups and let only the most docile ones reproduce. After several generations, the first dogs emerged. This hypothesis has been being tested in Novosibirsk since 1959, where foxes are being bred for “tamability.”

    2. centers of dog origins fromgenetic data have been proposed, including theMiddle East and East Asia

      In ref. 5, a genome-wide array of SNP between dogs and wolves suggest that dogs originate from Middle East.

      However, ref. 6, the comparison between dog and wolf mitochondrial DNA suggests East Asia as the center of dog origin.

    1. ere compared withcomplete mitochondrial genome sequences from49 wolves; 77 dogs, including divergent dog breedssuch as Basenji and Dingo; three recently publishedChinese indigenous dogs (7); and four coyotestotaling 148 mitochondrial genomes.

      The authors collected the mtDNA sequences previously published by other teams in order to get more data to analyze and a larger diversity of samples.

    2. DNA extracted from the earliest canids showingphenotypic evidence of domestication

      Some of the phenotypic adaptation can be observed, such as: shorter fangs and claws alteration of some brain areas.

      By comparing the DNA of phenotypically domesticated canids and actual dogs and identifying the genes which are responsible of the domesticate phenotype, it is possible to understand which genes have been altered by domestication and when they have been altered.

    3. centers of dog origins fromgenetic data have been proposed, including theMiddle East and East Asia

      In ref. 5, a genome-wide array of SNP between dogs and wolves suggest that dogs originate from Middle East.

      However, ref. 6, the comparison between dog and wolf mitochondrial DNA suggests East Asia as the center of dog origin.

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  17. May 2015
    1. Or more plainly: attention on social media both compensates for and is the logical endpoint of commoditized care work.

      I don't fully understand this but it was the most intriguing sentence in the piece for me. Are our social media services doing the care work of attending to our need for in-control socialization? Are they our new safe spaces that replace the therapist's office? I also wonder about whether people who work in a caring capacity have a unique relationship with social media.

  18. Mar 2015
    1. an objective set for the Sprint that can be met through the implementation of Product Backlog. It provides guidance to the Development Team on why it is building the Increment. It is created during the Sprint Planning meeting. The Sprint Goal gives the Development Team some flexibility regarding the functionality implemented within the Sprint. The selected Product Backlog items deliver one coherent function, which can be the Sprint Goal. The Sprint Goal can be any other coherence that causes the Development Team to work together rather than on separate initiatives.

      an objective set for the Sprint that can be met through the implementation of Product Backlog. It provides guidance to the Development Team on why it is building the Increment. It is created during the Sprint Planning meeting. The Sprint Goal gives the Development Team some flexibility regarding the functionality implemented within the Sprint. The selected Product Backlog items deliver one coherent function, which can be the Sprint Goal. The Sprint Goal can be any other coherence that causes the Development Team to work together rather than on separate initiatives.

  19. Nov 2014
    1. But to make the case for sex workers rights as functioning primarily to facilitate better care of children — rather than on rights and protections as intrinsic goods — is to accept the same gender confines prescribed by the activists so intent on reframing the majority of sex work as trafficking.
    2. But these features also make it ripe for conflict between sex worker activists and anti-trafficking activists who oppose sex work. One of the most frequent attacks on Twitter is that these activists are pimps pretending to be sex workers. This argument defeminizes sex workers into the masculine identity of a pimp and paints them as co-conspirators in trafficking. It’s a form of gendered shaming against female-identified sex workers that pits them over and against victimized women and girls
  20. Sep 2013
    1. But men who inculcate virtue and sobriety--is it not absurd if they do not trust in their own students before all others?

      It's almost as if they saw this as a job.