41 Matching Annotations
  1. Last 7 days
    1. Usage of an IS is not required in order for a client application to be part of the Matrix ecosystem. However, without one clients will not be able to look up user IDs using 3PIDs

      Better: linke from 3rd party to Matrix.

      E.g., by adding on Twitter link to Matrix ID.

  2. Apr 2024
    1. if I set a five year goal, I would then naturally chop it down into a series of yearly goals, then chop those into quarterly, then monthly, then weekly goals.

      Using GTD and reverse goal setting?

  3. Mar 2024
  4. Feb 2024
    1. 3:00 "and its long..." -- yeah, i have a 3MB obfuscated webapp at boxy-svg.com/app<br /> 3:05 "what would you do?" -- semi-automatic dynamic analysis. rename symbols. eval function calls. interact with the webapp (hence "semi" automatic). trace data in the debugger.<br /> but im still looking for a tool to do that for me... : P<br /> most tools fail on large files, or ESM (import, export) ...<br /> my current favorite is https://github.com/j4k0xb/webcrack and https://github.com/pionxzh/wakaru -- at least it works with ESM

    2. 3:15 My technique would be to copy it, paste it on stackoverflow and ask if someone knows what it does.

      in south america, they would find the original author, drug him with scopolamine, and make him give out the original source code : D aka social engineering<br /> they use this method to steal crypto from wealthy smart asses, who believe their money is "safe"

      similar to the $5 wrench in the "security" xkcd https://xkcd.com/538/

      see also<br /> https://www.youtube.com/watch?v=XJwU8Hiq4HM<br /> Careful with the New Crime Wave of Latin America

      1:42<br /> Scopolamine is a drug<br /> that basically makes you into a little slave, into a little servant,<br /> and you'll do whatever the attacker wants.

  5. Feb 2023
    1. According to Shulman, "Cargo-cult is a belief that mock airplanes made of manure and straw-bale may summon the real airplanes who bring canned beef. Reverse cargo-cult is used by the political elites in countries lagging behind who proclaim that, in the developed world, airplanes are also made of manure and straw-bale, and there is also a shortage of canned beef."[29]

      "Екатерина Шульман: Практический Нострадамус, или 12 умственных привычек, которые мешают нам предвидеть будущее". vedomosti/ (in Russian). Retrieved 24 June 2021.


      A Note on the Cargo Cult of Zettelkasten

      Modern cargo cults can be seen in many technology and productivity spaces where people are pulled in by exaggerated (or sometimes even real claims) of productivity or the general "magic" of a technology or method.

      An example is Niklas Luhmann's use of his zettelkasten which has created a cargo cult of zettelkasten aspirants and users who read one or more of the short one page blog posts about his unreasonable productivity and try to mimic it without understanding the system, how it works, or how to make it work for them. They often spend several months collecting notes, and following the motions, but don't realize the promised gains and may eventually give up, sometimes in shame (or as so-called "rubbish men") while watching others still touting its use.

      To prevent one's indoctrination into the zettelkasten cult, I'll make a few recommendations:

      Distance yourself from the one or two page blog posts or the breathless YouTube delineations. Ask yourself very pointedly: what you hope to get out of such a process? What's your goal? Does that goal align with others' prior uses and their outcomes?

      Be careful of the productivity gurus who are selling expensive courses and whose focus may not necessarily be on your particular goals. Some are selling very pointed courses, which is good, while others are selling products which may be so broad that they'll be sure to have some success stories, but their hodge-podge mixture of methods won't suit your particular purpose, or worse, you'll have to experiment with pieces of their courses to discover what may suit your modes of working and hope they'll suffice in the long run. Some are selling other productivity solutions for task management like getting things done (GTD) or bullet journals, which can be a whole other cargo cults in and of themselves. Don't conflate these![^1] The only thing worse than being in a cargo cult is being in multiple at the same time.

      If you go the digital route, be extremely wary of shiny object syndrome. Everyone has a favorite tool and will advocate that it's the one you should be using. (Often their method of use will dictate how much they love it potentially over and above the affordances of the tool itself.) All of these tools can be endlessly configured, tweaked, or extended with plugins or third party services. Everyone wants to show you their workflow and set up, lots of which is based on large amounts of work and experimentation. Ignore 99.999% of this. Most tools are converging to a similar feature set, so pick a reasonable one that seems like it'll be around in 5 years (and which has export, just in case). Try out the very basic features for several months before you change anything. Don't add endless plugins and widgets. You're ultimately using a digital tool to recreate the functionality of index cards, a pencil, and a box. How complicated should this really be? Do you need to spend hundreds of hours tweaking your system to save yourself a few minutes a year? Be aware that far too many people touting the system and marketers talking about the tools are missing several thousands of years of uses of some of these basic literacy-based technologies. Don't join their island cult, but instead figure out how the visiting culture has been doing this for ages.[^2] Recall Will Hunting's admonition against cargo cults in education: “You wasted $150,000 on an education you coulda got for $1.50 in late fees at the public library.”[^3]

      Most people ultimately realize that the output of their own thinking is only as good as the inputs they're consuming. Leverage this from the moment you begin and ignore the short bite-sized advice for longer form or older advice from those with experience. You're much more likely to get more long term value out of reading Umberto Eco or Mortimer J. Adler & Charles van Doren[^4] than you are an equivalent amount of time reading blog posts, watching YouTube videos, or trolling social media like Reddit and Twitter.

      Realize that reaching your goal is going to take honest-to-goodness actual work, though there is potential for fun. No matter how shiny or optimized your system, you've still got to do the daily work of reading, watching, listening and using it to create anything. Focus on this daily work and don't get sidetracked by the minutiae of trying to shave off just a few more seconds.[^5] In short, don't get caught up in the "productivity porn" of it all. Even the high priest at whose altar they worship once wrote on a slip he filed:

      "A ghost in the note card index? Spectators visit [my office to see my notes] and they get to see everything and nothing all at once. Ultimately, like having watched a porn movie, their disappointment is correspondingly high." —Niklas Luhmann. <small>“Geist im Kasten?” ZKII 9/8,3. Niklas Luhmann-Archiv. Accessed December 10, 2021. https://niklas-luhmann-archiv.de/bestand/zettelkasten/zettel/ZK_2_NB_9-8-3_V. (Personal translation from German with context added.)</small>


      [^1] Aldrich, Chris. “Zettelkasten Overreach.” BoffoSocko (blog), February 5, 2022. https://boffosocko.com/2022/02/05/zettelkasten-overreach/.

      [^2]: Blair, Ann M. Too Much to Know: Managing Scholarly Information before the Modern Age. Yale University Press, 2010. https://yalebooks.yale.edu/book/9780300165395/too-much-know.

      [^3]: Good Will Hunting. Miramax, Lawrence Bender Productions, 1998.

      [^4]: Adler, Mortimer J., and Charles Van Doren. How to Read a Book: The Classic Guide to Intelligent Reading. Revised and Updated edition. 1940. Reprint, New York: Simon & Schuster, 1972.

      [^5]: Munroe, Randall. “Is It Worth the Time?” Web comic. xkcd, April 29, 2013. https://xkcd.com/1205/.


      Recommended resources

      Choose only one of the following and remember you may not need to read the entire work:

      Ahrens, Sönke. How to Take Smart Notes: One Simple Technique to Boost Writing, Learning and Thinking – for Students, Academics and Nonfiction Book Writers. Create Space, 2017.

      Allosso, Dan, and S. F. Allosso. How to Make Notes and Write. Minnesota State Pressbooks, 2022. https://minnstate.pressbooks.pub/write/.

      Bernstein, Mark. Tinderbox: The Tinderbox Way. 3rd ed. Watertown, MA: Eastgate Systems, Inc., 2017. http://www.eastgate.com/Tinderbox/TinderboxWay/index.html.

      Dow, Earle Wilbur. Principles of a Note-System for Historical Studies. New York: Century Company, 1924.

      Eco, Umberto. How to Write a Thesis. Translated by Caterina Mongiat Farina and Geoff Farina. 1977. Reprint, Cambridge, MA, USA: MIT Press, 2015. https://mitpress.mit.edu/books/how-write-thesis.

      Gessner, Konrad. Pandectarum Sive Partitionum Universalium. 1st Edition. Zurich: Christoph Froschauer, 1548.

      Goutor, Jacques. The Card-File System of Note-Taking. Approaching Ontario’s Past 3. Toronto: Ontario Historical Society, 1980. http://archive.org/details/cardfilesystemof0000gout.

      Sertillanges, Antonin Gilbert, and Mary Ryan. The Intellectual Life: Its Spirit, Conditions, Methods. First English Edition, Fifth printing. 1921. Reprint, Westminster, MD: The Newman Press, 1960. http://archive.org/details/a.d.sertillangestheintellectuallife.

      Webb, Sidney, and Beatrice Webb. Methods of Social Study. London; New York: Longmans, Green & Co., 1932. http://archive.org/details/b31357891.

      Weinberg, Gerald M. Weinberg on Writing: The Fieldstone Method. New York, N.Y: Dorset House, 2005.

  6. Jan 2023
    1. to get rid   of monopoly rent you have to return basic key  uh infrastructure to the public domain where   it was before 1980 so that uh basic needs can be  supplied at low prices not uh creating monopoly   for uh the one percent uh and i guess i'm saying  you have to realize that finance has used as well   00:25:12 to take over the economy and this has to  be reversed uh because uh once you have   uh wealth taking the form of uh claims uh  loans and claims on other people's debt   we'll count you up compound interest any rate of  interest is a doubling time and compound interest   is always going to grow faster than the economy's  real growth and the only way to prevent this isn't   00:25:37 simply to lower the interest rate which you've  done today 0.1 uh the only solution is to wipe out   the overall debts that are stopping economic  growth and these debts are the savings of the   one percent the good thing about cancelling debts  is you cancel the savings of the one percent   and as long as you leave these savings in  place there's not going to be a solution

      !- Michael Hudson : reverse privatization and wipe out debt - returning the public infrastructure sold off to companies after 1980 back to the public to get rid of monopolies who gouge the public - cancel all debt so that the savings of the 1% cannot continue compound growth trajectory

  7. Sep 2022
    1. Harris further illustrates hisown idea of voices adding to an author’s text; each chapter contains multiple “intertexts,”which are small graphics with citation references to outside materials addressed nearby inthe text. These intertexts reinforce the practice of adding voices to the author’s docu-ment. These illustrations are effective; essentially, Harris is reflecting and modeling thepractice.

      I quite like the idea of intertexts, which have the feeling of annotating one's own published work with the annotations of others. A sort of reverse annotation. Newspapers and magazines often feature pull quotes to draw in the reader, but why not have them as additional voices annotating one's stories or arguments.

      This could certainly be done without repeating the quote twice within the piece.

  8. Jul 2022
    1. At the same time, like Harold, I’ve realised that it is important to do things, to keep blogging and writing in this space. Not because of its sheer brilliance, but because most of it will be crap, and brilliance will only occur once in a while. You need to produce lots of stuff to increase the likelihood of hitting on something worthwile. Of course that very much feeds the imposter cycle, but it’s the only way. Getting back into a more intensive blogging habit 18 months ago, has helped me explore more and better. Because most of what I blog here isn’t very meaningful, but needs to be gotten out of the way, or helps build towards, scaffolding towards something with more meaning.

      Many people treat their blogging practice as an experimental thought space. They try out new ideas, explore a small space, attempt to come to understanding, connect new ideas to their existing ideas.


      Ton Zylstra coins/uses the phrase "metablogging" to think about his blogging practice as an evolving thought space.


      How can we better distill down these sorts of longer ideas and use them to create more collisions between ideas to create new an innovative ideas? What forms might this take?

      The personal zettelkasten is a more concentrated form of this and blogging is certainly within the space as are the somewhat more nascent digital gardens. What would some intermediary "idea crucible" between these forms look like in public that has a simple but compelling interface. How much storytelling and contextualization is needed or not needed to make such points?

      Is there a better space for progressive summarization here so that an idea can be more fully laid out and explored? Then once the actual structure is built, the scaffolding can be pulled down and only the idea remains.

      Reminiscences of scaffolding can be helpful for creating context.

      Consider the pyramids of Giza and the need to reverse engineer how they were built. Once the scaffolding has been taken down and history forgets the methods, it's not always obvious what the original context for objects were, how they were made, what they were used for. Progressive summarization may potentially fall prey to these effects as well.

      How might we create a "contextual medium" which is more permanently attached to ideas or objects to help prevent context collapse?

      How would this be applied in reverse to better understand sites like Stonehenge or the hundreds of other stone circles, wood circles, and standing stones we see throughout history.

  9. Apr 2022
    1. Much of this sort of information was later reverse-engineered, and cross-browser support for basic operations is actually quite good. (Browsers still vary widely on the details.)
    2. Reverse-engineering and standardizing contentEditable
  10. Feb 2022
    1. Yen, H.-L., Sit, T. H., Brackman, C. J., Chuk, S. S., Cheng, S. M. S., Gu, H., Chang, L. D., Krishnan, P., Ng, D. Y., Liu, G. Y., Hui, M. M., Ho, S. Y., Tam, K. W., Law, P. Y., Su, W., Sia, S. F., Choy, K.-T., Cheuk, S. S., Lau, S. P., … Poon, L. L. (2022). Transmission of SARS-CoV-2 (Variant Delta) from Pet Hamsters to Humans and Onward Human Propagation of the Adapted Strain: A Case Study (SSRN Scholarly Paper ID 4017393). Social Science Research Network. https://doi.org/10.2139/ssrn.4017393

  11. Jan 2022
    1. RBI has not yet formally announced any “normalization” procedure, though absorption of excess liquidity was attempted by increasing the cut-off yield rate of variable rate reverse repo (VRRR) to 3.99%, and curtailing the government securities acquisition programme

      Variable Reverse Repo-rate

  12. Nov 2021
    1. One reason why citizen driven and community based initiatives struggle is that there is no ‘reverse value capture’ mechanism — a way to capture value for regenerative activity undertaken to improve communities — because it often falls outside the realm of market transactions.

      This is based on the fundamental misconception of the value that the commons adds to society.

  13. Aug 2021
    1. Repeated treatment with (-)U-50,488H (s.c. or i.c.v.) significantly enhanced antinociceptive effect of both mu-opioid receptor agonist (morphine) and delta-opioid receptor agonists

      Just confirming what I believed to be the case. I couldn't remember whether I'd read results of this specific sort, so I figured I should look it up. Chronic KOR agonism appears to be an ideal opioid hack.

  14. Jun 2021
    1. I've been thinking more about how to best do this. The preferred way might be to use the same domain and have an application load balancer like nginx split traffic on the URL path (e.g. /api). This is for two reasons. Firstly, you might not necessarily want to cookie the primary/apex domain and have the cookie shared across all subdomains. You also might not want to do CORS because preflight requests add latency and CORS adds complication.
  15. May 2021
    1. In contrast to its acute administration, repeated salvinorin A administration did not modify dialysate DA levels. Similarly, neither basal extracellular DA levels nor DA uptake was altered. Unlike synthetic KOPr agonists, prior repeated administration of salvinorin A did not attenuate the locomotor activating effects of an acute cocaine (20 mg/kg, i.p.) challenge. However, cocaine-evoked DA overflow was enhanced.

      Fascinating and useful stuff. This is close to what I was expecting. Though, I was expecting chronic exposure to upregulate dopamine beyond baseline. If I'm understanding this correctly, it was upregulated in the sense that it enhanced the dopaminergic effects of cocaine. I've not yet read the full study.

  16. Apr 2021
    1. However, coadministration of nefiracetam (5 or 10 mg/kg, p.o.), enprofylline (30 mg/kg, p.o.) and rolipram (0.3 or 1 mg/kg, i.p.) with morphine during the pretreatment period, significantly reduced the withdrawal signs, moreover, the tolerance was significantly attenuated.

      Looks promising. It's odd that theophylline had a lesser effect.

    1. Conclusion: Our data suggest that the combination of VLF with morphine may be a relevant therapeutic implication to manage pain even when tolerance to morphine exists. Moreover, our data demonstrates the involvement of L-Arg/NO/cGMP pathway in the prevention of morphine tolerance and dependence by venlafaxine.

      It's not clear if this has relevance to the subjective effects. I'm starting to think that I won't get an answer anytime soon.

    1. Results: Tadalafil showed anti-nociceptive effect when given alone at different doses (p<0.05). However, tadalafil significantly decreased the analgesic effect of morphine (p<0.05). In addition, tadalafil significantly increased the tolerance to morphine (p<0.05). Conclusions: The phosphodiesterase type 5 inhibitor tadalafil have anti-nociceptive properties and it decreases analgesic effect of morphine, in addition improves tolerance development. These effects probably may occur via NO/cGMP pathway.

      This is analgesia, so is not necessarily relevant for my purposes. Nonetheless, there implies some relevance of cGMP, but the direction isn't yet clear.

    1. Repeated KOR agonist exposure, on the other hand, can result in opposing effects on the dopamine system [27], and desensitization of the KOR [28]

      If they mean what I think they mean, then this implies that chronic KOR is useful. I'll need to check citation 27.

    1. These data suggested that PAT, an indirect-acting KOR agonist, share the common pharmacological property of KOR agonists on morphine tolerance

      PAT is apparently an herbal medicine I should look into. They also imply that KOR agonists act as I expect they do, but I'll need to read the full study to be sure.

      Edit: yup, it appears that chronic KOR agonism is probably a good idea.

      from full text "Utility of KOR agonists is a promising pharmacological tool for attenuating morphine tolerance (Pan, 1998), however, it is difficult to find effective KOR agonists that are devoid of dysphoric and psychotomimetic adverse effects in humans"

      This is the cited study.

    1. The results also showed that diltiazem was able to selectively potentiate the analgesic effect of morphine but not of fentanyl (the reason was not known).

      Fascinating. However, this provides no insight into the subjective effects. However, it does reduce my certainty that any given combination of drugs (sharing these mechanism) will work. There doesn't seem to be consistent results with these L-CCBs plus opioid studies.

    1. The results suggest the euphorigenic and analgesic effects of opioids may be differentiated by using Ca++ channel blockers.

      Yes. That also means that most of the rat studies I've been reading are useless for my purposes.

    1. Results:Nimodipine when administered as a single bolus dose before naloxone administration in morphine-dependant rats reduced the features of withdrawal reactions more effectively than continuous administration of nimodipine along with morphine throughout the experimental period.

      Weird and surprising.This plausibly implies that L-type calcium channel blockers may not be as effective as it first appears.

    1. Nimodipine controlled the escalation of the morphine dose in 9 patients (65%), and placebo in 4 (28%), the difference being statistically significant (P=0.03).

      Consistent with rat data. This is from 1998. I'm sure there's more evidence by now. It's been a while since i researched this, but I think I've previously seen at least one other study.

    1. These results suggest that the elevation of the cyclic AMP levels is involved in the development of morphine withdrawal syndrome and that blockade of the morphine-induced reduction of cyclic AMP levels by chronic rolipram inhibits the development of dependence and the behavioural and biochemical changes induced by naloxone. Furthermore, rolipram may be a useful drug for attenuating the development of morphine dependence.

      Excellent. This implies that theobromine may help prevent opioid tolerance.

  17. Feb 2021
  18. Dec 2020
    1. The return (backward-pointing) address in the envelope is changed so that all error messages generated by the final deliveries will be returned to a list administrator, not to the message originator, who generally has no control over the contents of the list and will typically find error messages annoying.
      1. This the only difference between an SMTP alias and list; expanding recipients to RCPT commands is the same.
      1. Another great example to highlight the difference between SMTP envelope and mail data: the envelope's MAIL FROM (see annotation) is different from to the mail data's rfc822 From:.
    2. the reverse-path (originator) address specification command (MAIL)

      Sometimes "reverse path" or "originator" address is also referred to "backward-pointing" address (and those instances also refer to the MAIL command mostly).

  19. Aug 2020
  20. Jul 2020
  21. Mar 2019
  22. Jan 2019
    1. inverse agonist activity was not required for mu-opioid receptor up-regulation and supersensitivity.

      The question, then, is whether the opioid receptors are involved at all in this upregulation. For example, it could be mediated by TLR4 or filamin A.

  23. Apr 2018
  24. Jul 2016
  25. Oct 2015
    1. Here in the city-escapes, under bridges, ingraveyards and side streets, street children have formed “flourishing”outdoor communities, some with elaborate order, discipline, and an