- Apr 2024
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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RRID:AB_2800125
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SCR_016547
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RRID:CVCL_0004
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RRID:SCR_002798
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BDSC:32551
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CVCL_0347
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plasmid_12260
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plasmid_18770
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RRID:Addgene_163612
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RRID:Addgene_20076
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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RRID:SCR_014329
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RRID:AB_465415
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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RRID:Addgene_42250
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RRID:SCR_014242
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RRID:AB_67023
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RRID:IMSR_JAX:016962
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RRID:AB_823120
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plasmid_26220
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CRL_3216
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accesspharmacy-mhmedical-com.ezproxy.lib.uconn.edu accesspharmacy-mhmedical-com.ezproxy.lib.uconn.edu
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β3-adrenergic agonists
miberagon
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web.mit.edu web.mit.edu
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u and v now have degree at most 1 since they had degree atmost two before we removed edge (u, v)
so they're like leaves...
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all the nodes are isolated
(so g is the union of N disjoint subgraphs)
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Each node can have degree at most two, so g can haveat most N edge
Maybe explain this more carefully
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docdrop.org docdrop.orgUntitled4
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Wheneveranythingisgoodorbadforsomeone,it’sbecauseoftheirconsciousness.
emotions*
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Others switch to killing the chicken,presumably because they think the zombies have some degree of moralstatus, perhaps deriving from their intelligent behavior.
unconscious emotional creatures may not experience emotion but still demonstrate emotional behavior.
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magine something as close to us as possible without thecapacity for consciousness.
(maybe quote this)- as long as zombies can feel emotions, they can have wellbeing. If, for the sake of the though experiment, these zombies are the closest thing to us without consciousness, then it's reasonable to think they can still have emotions. They lose the ability to experience these emotions like we do, but they can still feel certain things emotionally, like how we can experience emotions unconsciously.
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If it can experience something,that should be taken into account in our moral calculations.
my own view- if it can emotionally feel somethings it has wellbeing (therefore moral status)
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hebstr.quarto.pub hebstr.quarto.pub
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biais
test 2
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www.wheresyoured.at www.wheresyoured.at
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These emails — which I encourage you to look up — tell a dramatic story about how Google’s finance and advertising teams, led by Raghavan with the blessing of CEO Sundar Pichai, actively worked to make Google worse to make the company more money. This is what I mean when I talk about the Rot Economy — the illogical, product-destroying mindset that turns the products you love into torturous, frustrating quasi-tools that require you to fight the company’s intentions to get the service you want.
Rot Economy: taking value from the users
Not [[enshitification]]…Value was taken directly from the users to the company. Is there a parallel to recent Boeing actions here?
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scalar.lafayette.edu scalar.lafayette.edu
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This left Flint in a state of financial turmoil, driving away affluent residents and setting the stage for an environmental disaster.
Pulido, Laura. “Flint, Environmental Racism, and Racial Capitalism.” Capitalism Nature Socialism 27 (2016): 1–16.
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Following a timber boom in the 1830’s, an abundance of paper mills moved into the city, marking the beginning of Flint River’s contamination.12
Pulido, Laura. “Flint, Environmental Racism, and Racial Capitalism.” Capitalism Nature Socialism 27 (2016): 1–16.
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The area was first colonized in the early 1800s, and quickly suffered from one of the worst cases of deindustrialization.12
Pulido, Laura. “Flint, Environmental Racism, and Racial Capitalism.” Capitalism Nature Socialism 27 (2016): 1–16.
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The disaster begins In April, 2014, when Flint, Michigan decided to switch over from their typical water source, the Detroit city system, to the Flint River in an attempt to save money.11 The Governor of Flint declared a financial emergency, hoping to save 18 million dollars over eight years.
Denchak, Melissa. “Flint Water Crisis: Everything You Need to Know.” NRDC, last modified November 8, 2018.
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Researchers at Virginia Tech conducted a study a year later, revealing spiked lead levels, with almost 17% of samples registered above the federal action level.
Denchak, Melissa. “Flint Water Crisis: Everything You Need to Know.” NRDC, last modified November 8, 2018.
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www.edenintelfin.com www.edenintelfin.com
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Typical clients
专注客户
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Price
价格
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Pacakge
套餐
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www.technologyreview.com www.technologyreview.com
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A grander sense of partnership is in the air now. What were once called AI bots have been assigned lofty titles like “copilot” and “assistant” and “collaborator” to convey a sense of partnership instead of a sense of automation. Large language models have been quick to ditch words like “bot” altogether.
AI entities are now anthropomorphized
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Norman, now 88, explained to me that the term “user” proliferated in part because early computer technologists mistakenly assumed that people were kind of like machines. “The user was simply another component,” he said. “We didn’t think of them as a person—we thought of [them] as part of a system.” So early user experience design didn’t seek to make human-computer interactions “user friendly,” per se. The objective was to encourage people to complete tasks quickly and efficiently. People and their computers were just two parts of the larger systems being built by tech companies, which operated by their own rules and in pursuit of their own agendas.
“User” as a component of the bigger system
Thinking about this and any contrast between “user experience design” and “human computer interaction”. And about schema.org constructs embedded in web pages…creating web pages that were meant to be read by both humans and bots.
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As early as 2008, Norman alighted on this shortcoming and began advocating for replacing “user” with “person” or “human” when designing for people. (The subsequent years have seen an explosion of bots, which has made the issue that much more complicated.) “Psychologists depersonalize the people they study by calling them ‘subjects.’ We depersonalize the people we study by calling them ‘users.’ Both terms are derogatory,” he wrote then. “If we are designing for people, why not call them that?”
“User” as a depersonalized, derogatory term
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Local file Local file
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Activación de los canales proteicos.
Importante para el apunte. Activación e los canales proteicos.
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bibliodig.uag.mx:2056 bibliodig.uag.mx:2056
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permite la penetración de algunas sustancias del exterior
???
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social-media-ethics-automation.github.io social-media-ethics-automation.github.io
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Terry Gross. Director Bo Burnham On Growing Up With Anxiety — And An Audience. NPR, July 2018. URL: https://www.npr.org/2018/07/18/630069876/director-bo-burnham-on-growing-up-with-anxiety-and-an-audience (visited on 2023-12-08).
Bo Burnham's interview reveals his empathy and insight into the creation of Eighth Grade. He talks about his personal struggles with anxiety as a young performer, which influenced the film's narrative and his desire to capture his childhood. Burnham's commitment to portraying the emotional experiences of teenagers is is really shown through his thoughtful storytelling and dedication to empowering young actors. His reflections on his early comedic material also showcase a profound understanding of personal growth and self-expression.
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social-media-ethics-automation.github.io social-media-ethics-automation.github.io
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How might the mental health of different people or groups be benefited by this social media site? List as many as you can think of (bullet points encouraged).
- Community Support
- Expression and Creativity
- Positive Affirmations
- Education and Awareness
- Inspiration and Motivation
- Self-Reflection
- Relaxation
- Seeking Help
- Connecting with Experts.
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www.nybooks.com www.nybooks.com
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Left Behind by [[Nancy Isenberg]]
This is of interest because Isenberg's White Trash came out in January 2016 just a five months before Vance's Hillbilly Elegy was released. As a result she didn't get to reference it in her book.
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drive.google.com drive.google.com
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as e-atividades no contexto doensino e aprendizagem em ambientes virtuais.
Boa noite a tod@s, Perante este contexto, pode-se concluir que as e-atividades bem concebidas e desenvolvidas, que levem em consideração as necessidades e perspectivas de todas as partes interessadas, desempenham um papel crucial no ensino e aprendizagem online, ao criar um ambiente envolvente, colaborativo e flexível, que promove a participação ativa e a construção coletiva de conhecimento. Cordiais Saudações, Patrícia Pinheiro
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www.actu-environnement.com www.actu-environnement.com
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supercoiling helps incellular packaging of DNA in structures called nucleosomes, in whichDNA is wound around proteins called histones
nucleosomes make up chromatin which makes up chromosomes
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cruciforms
form from palindromic sequences; important for cruciform-binding proteins during DNA replication
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polyrnerases
replicates DNA molecules after helicase unzips to actually build a new strand of DNA
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helicases
The "unzipping" enzyme which breaks the hydrogen bonds holding the two strands together
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Supercoiling of closed DNA is ubiquitous in biological systems
So it's not some niche or theoretical occurrence and it isn't just synthesized by scientists
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may, in general, assume almostany configuration in space
so axis can be a knot!
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xis ofthe double helix may itself be a helix
Maybe try to find a diagram for this...idk But do explain what a helix is
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commonlinear axis
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fundamental theorem
excellent
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bigthink.com bigthink.com
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Have you ever had a meaningful conversation with Siri or Alexa or Cortana? Of course not.
That said, I have had some pretty amazing conversations with ChatGPT-4. I've found it to be useful, too, for brainstorming. In one recent case (which I blogged about on my personal blog), the AI helped me through figuring out a structural issue with my zettelkasten.
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rtificial intelligence is already everywhere
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repository.urosario.edu.co repository.urosario.edu.co
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AAIDD: Asociación Americana de Discapacidades Intelectuales y del Desarrollo
bla bla bla
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The past made us who we are today, and the future will make us into something new. And, if Bostrom is right, it’ll make us happier.
I doubt it.
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“Did you know that the first Matrix was designed to be a perfect human world? Where none suffered, where everyone would be happy. It was a disaster. No one would accept the program… I believe that, as a species, human beings define their reality through suffering and misery. The perfect world was a dream that your primitive cerebrum kept trying to wake up from.”
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“I don’t want comfort. I want God, I want poetry, I want real danger, I want freedom, and I want goodness. I want sin.”
Exactly.
Too many people would want conflict. The source of the conflict is not scarcity: it's human nature.
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“It generally becomes easier to be generous if you’re doing well and you have a big windfall, [because] when there isn’t enough for everybody, it’s just a question of who is going to starve, and then everything becomes much tougher,” Bostrom told Big Think.
Tell that to the super-rich.
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erif concluded that scarcity was one of the main drivers of all human conflict. War, violence, invasion, and theft were all born of wanting a limited resource. The history of all humanity seems to support the hypothesis: We fight over water, cattle, arable land, ore deposits, oil, precious stones, and so on.
He concluded incorrectly.
Rich people already have more resources than they could ever use. The richest amongst us could not ever spend all the money they possess. But that does not seem to have stopped them from continuing to want more, and more, and more.
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pubs.acs.org pubs.acs.org
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Cubic dependence of permselectivity on charge density
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carnap.io carnap.io
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(9) and (10)
Correction: (7) and (8)
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onlinelibrary.wiley.com onlinelibrary.wiley.com
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‘I have to regulate how much energy I use, like, if I have to work then I'm more tired when I get home, but since I know this, I try to rest before leaving home’.
adults not wanting to understand their limitations due to fear of being looked at as lazy.
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‘I was talking with a friend who also has the same situation and she told me that when she went out with friends and didn't know if there was a toilet nearby, what she did was not to eat, so that she wouldn't want to go to the bathroom, so that's what I do too’.
fear of embarrassment. having someone to talk to about their experiences that can relate to.
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self-protection was accompanied by an open distrust on the health system.
self-protection leading to distrust on the health system turns to a feeling of hopelessness.
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necessary to control their emotional situation and avoid stress so as not to worsen their illness: C10 ‘I suffer from stress, which I try to control’;
giving crohns disease patients tools to control their stress at different stages of life.
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www.vox.com www.vox.com
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Cohen, Rachel M. “What the Supreme Court Case on Tent Encampments Could Mean for Homeless People.” Vox, April 21, 2024. https://www.vox.com/scotus/24123323/grants-pass-scotus-supreme-court-homeless-tent-encampments.
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The American Psychiatric Association noted that police are also more likely to use excessive force when they interact with unhoused people with mental illness. Even when “well-intentioned law enforcement responders” respond to calls for help, according to the Substance Abuse and Mental Health Services Administration, the situations often escalate due to “the presence of police vehicles and armed officers that generate anxiety.”
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More than one-fifth of people experiencing homelessness currently have a serious mental illness like bipolar disorder or schizophrenia, and the US Department of Justice has found that “the prevalence of unmet behavioral health needs” is a key driver in why “people who experience homelessness tend to have frequent (and often repeat) interactions with law enforcement.”
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Willison’s research found that 22 percent of mayors from over 120 cities station their homelessness staff within police departments. Even among those cities that station homeless outreach teams elsewhere, most still include formal roles for police. Seventy-six percent of homeless outreach teams formally involve the police, per another study she co-published last year.
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“The crux of the issue is we’re thinking about the focus on encampment closure without access to housing,” said Charley Willison, a Cornell professor who has studied the influence of police on cities’ homelessness policies.
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The city council president said Grants Pass’s goal was to “make it uncomfortable enough for them in our city so they will want to move on down the road.”
Why is it that so many of Americans' gut reactions is to "kick the can down the road" rather than to solve the underlying problems?
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“The Ninth Circuit and respondents have tried to downplay the ways in which the ruling ties local leaders’ hands, but their arguments only confirm the decision’s ambiguity and unworkability,” Democratic California Gov. Gavin Newsom wrote in an amicus brief filed in September.
I'm surprised to see this stance from Gavin Newsom... though California probably faces a higher level of homelessness than most states as a result of its weather.
Does it though? What are the rates of homelessness as a percentage of population per state? What do the overall numbers look like for CA as a percentage of the total?
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In Grants Pass v. Johnson, the Supreme Court will decide whether it constitutes cruel and unusual punishment to fine, ticket, or jail someone for sleeping outside on public property if they have nowhere else to go. A ruling in favor of the plaintiffs would make it easier for communities to clear out homeless people’s tent encampments, even if no available housing or shelter exists.
Tags
- mental health
- rental assistance
- policy
- problem solving
- Martin v. Boise
- communities
- homelessness
- help portals
- procrastination
- cruel and unusual punishment
- quotes
- sociology
- social safety nets
- credit scores
- homelessness and mental illness
- refugee camps
- housing crisis
- read
- Grants Pass v. Johnson
- schizophrenia
- poverty
- Supreme Court of the United States
- References
- sanctioned encampment sites
- the commons
- humanity
- police as social workers
- human resources
- well-being
- Gavin Newsom
- bipolar disorder
- basic needs
- kicking the can down the road
- public property
- human rights
- police shouldn't be social workers
- homelessness and policing
- housing policy
- open questions
- power over
- municipal governments
- Charley Willison
Annotators
URL
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www.verywellhealth.com www.verywellhealth.com
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However, Crohn’s disease is not a condition for which there is a regular screening tool. The diagnosis is based on symptoms leading to testing. One test procedure is a colonoscopy (a flexible tube with a camera is inserted through the anus to visualize the colon), in which biopsies (tissue samples) are taken to be analyzed in the lab.
explaining procedures and what will be done to them in order to diagnose or teat their disease. How I felt duing this process. What was my understanding of what was going on?
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www.ebay.com www.ebay.com
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Rolodex Item #67380 https://www.ebay.com/itm/166733559184
You have to appreciate the way that this zettelkasten is designed to be decorative and include personal family photos almost as a representation of what it directly contains.
Caption: A small rolodex file in grey and black plastic with a picture frame on the front with space for a small photo, in this case either a picture of a young child or a family dog
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davekarpf.substack.com davekarpf.substack.com
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Will the escalation of protests and reaction by Columbia University’s President, Minouche Shafik cause an ultimate shift in American sentiment because she reacted in the wrong way to quell protests in Spring 2024? Will things escalate as they did in 1968 and spill over into actual change in society and culture?
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The only thing university administrators had to do was NOTHING. by [[Dave Karpf]]
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Saul Alinsky writes that “the action is in the reaction.”
original source?
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You only win against these Congressional Republicans by refusing to play their game.
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Don’t treat televised spectacle like a deposition. It will go badly for you in all the very predictable ways.
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The way that administrators normally respond to a tactic like this is to just wait it out. Have campus security keep an eye on them to make sure things don’t get out of hand. Make vague statements to the campus paper. Schedule some meetings. Maybe declare that you’ll form a committee to look into things further.Traditionally, the weakness of this tactic is that it does little to expand the conflict.
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Schattschneider tells us that contentious politics can be best understand through a lens of conflict expansion. Those in power will (and, strategically, should) try to maintain and contain the scope of a conflict. Those arrayed against them will (and should) attempt to expand the scope of the conflict. If you want to understand an episode of contentious politics, don’t evaluate the substance of the arguments as though you are judging an intercollegiate debate. Instead, watch the crowd.
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One book that I have my students read every semester is E.E. Schattschneider’s 1960 classic, The Semi-Sovereign People. The book is a tight 180 pages.
Tags
- Minouche Shafik
- pending American civil war
- 1968
- political communication
- Columbia University
- wisdom of the crowds
- Republican party
- university administration
- civil unrest
- political protests
- reactions
- depositions
- political tactics
- E. E. Schattschneider
- quotes
- public spectacle
- Gaza protests (2024)
- political strategy
- conflict
- liberal academia
- cancel culture
- conflict expansion
- academia
- strategic political communication
- The Semi-Sovereign People
- protests
- read
- Democracy
- action and reaction
- free speech
- communications
- Saul Alinsky
- government
- politics
- culture wars
Annotators
URL
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www.youtube.com www.youtube.com
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Irónicamente, lo que me ha generado este video, fue la total inconsciencia que se tiene actualmente en el ministerio de educación Ecuatoriano, puesto que a pesar de tener presente estos enfoques de metodologías activas y más efectivas. Como la mencionada en el mismo video, pues aun teniendo tal conocimiento, no son capaces de implementarlo en el documento curricular del país, por lo que en la mayoría de las instituciones la mayoría de los docentes no actúan como mediadores, ni mucho menos ponen en práctica el modelo constructivista, esto debido al mal manejo del curriculum en sus tres niveles, el macro curricular, meso curricular y el micro curricular. Lo que ha dado como resultado un total olvido e inconsciencia, de los métodos brindados por aquellos precursores, benefactores de una educación, mucho más significativa para los estudiantes, algunos de ellos vendrían a ser: Jean Piaget; Con un enfoque en el aprendizaje en le entorno, Levt Vygostki; Centrándose en la Interacción con las personas, que permite una mayor asequibilidad de la comprensión en los estudiantes y por supuesto David Ausubel quien es el creador del aprendizaje significativo.
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library.scholarcy.com library.scholarcy.com
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Kim i in. (2014) stwierdzili, że w porównaniu z osobami bez ADHD, młodzi dorośli z ADHD wykazywali niedobór w różnych testach, które oceniały funkcje wzrokowe, w tym percepcję głębi, widzenie peryferyjne, wyszukiwanie wzrokowe, szybkość przetwarzania wzrokowego i percepcję kolorów oraz że te problemy sensoryczne mogą prowadzić do trudności podczas prowadzenia pojazduKiedy te obwody poznawcze zostały zbadane za pomocą funkcjonalnego rezonansu magnetycznego, ścieżki połączeń funkcjonalnych "od odczucia do poznania", które pochodzą z pierwotnej kory czuciowej i łączą się z uwagą czołową i obszarami funkcji wykonawczych, takimi jak kora przedczołowa (PFC), są zmniejszone u pacjentów z ADHD w porównaniu z osobami kontrolnymi (Carmona i in., 2015)
Funkcje wzrokowe (w tym głębia) z deficytem w ADHD
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two-wrongs.com two-wrongs.com
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We often think of software development as a ticket-in-code-out business but this is really only a very small portion of the entire thing. Completely independently of the work done as a programmer, there exists users with different jobs they are trying to perform, and they may or may not find it convenient to slot our software into that job. A manager is not necessarily the right person to evaluate how good a job we are doing because they also exist independently of the user–software–programmer network, and have their own sets of priorities which may or may not align with the rest of the system.
Software development as a conversation
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www.linkandth.ink www.linkandth.ink
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Cohesion via Standards and Protocols
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www.youtube.com www.youtube.com
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First LiaScript-User-Symposium
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www.nytimes.com www.nytimes.com
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I guess her own self-description that it doesn’t actually matter where she stops, that the important thing in the making of the painting is the making and destroying and making and destroying, that that’s actually what the whole thing is about.
Deciding where to stop is a choice onto itself
This session had me in a panic: how do we put descriptive metatata on this? Where would we draw the line between different representations of the work? Which representation becomes the featured one…the one the artist picked as a point on the timeline of creation, the one the describer picked for an aesthetic reason, one one that broke through in the public consciousness?
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There are, in my view, three stages of making art. One of them is the imagining, and the final one is the shaping. But in between, there is the judging, which is kind of what we’re talking about here, the editing.
Three stages of creation: imagining, judging, shaping
it is the middle one that is often invisible to the point of being lost. That is the role of editing.
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Now, many people, when they read, listen to anything, when they take in media, they don’t necessarily even know where it was from.
The lost role of the editor with the decontainerization of digital media
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The Work of Art, How Something Comes From Nothing
Publisher link. He talks later in the podcast about how the physical book itself is a work of art..from the texture of the paper (which he thought was too smooth) to the cloth cover (which he pointedly advocated for with the publisher).
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www.linkedin.com www.linkedin.com
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Serge SONFACK reposted this
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www.linkedin.com www.linkedin.com
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Serge SONFACK 2nd degree connection 2nd Knowledge representation and reasoning, logic programming and collaborative intelligence.
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wiki.c2.com wiki.c2.com
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Lisp Humor
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www.linkedin.com www.linkedin.com
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On this day in 1959, "LISP,
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jmc.stanford.edu jmc.stanford.edulisp.pdf1
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History of Lisp
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library.scholarcy.com library.scholarcy.com
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Heterogeniczna prezentacja nieprawidłowości czuciowych w ADHD sugeruje, że supramodalne regiony mózgu są również zaangażowane w te objawy. Na przykład przerzedzenie kory mózgowej zostało zaproponowane jako marker ADHD (Narr i in., 2009). Podczas gdy kora asocjacyjna, w której zachodzi duża integracja sensoryczna, wykazywała ścieńczenie kory, pierwszorzędowe regiony czuciowe miały w dużej mierze typową grubość, co sugeruje neuronalny korelat upośledzenia integracji multisensorycznej w ADHD. Ponadto obszary, które są połączone z układami sensorycznymi i mają tendencję do modulacyjnego wpływu na korę czuciową, takie jak móżdżek (Cao, Shu, Cao, Wang i He, 2014; Czerkasowa i Hechtman, 2009; Davis i in., 2009; Goetz i in., 2014; Hong i in., 2014; Uddin i in., 2017), zwoje podstawy (Di Martino i in., 2013; Hong i in., 2014; Pereira i in., 2016), kora czołowa (Hong i in., 2014; Pereira i in., 2016; Uddin i in., 2017) i ciało migdałowate (Cocchi i in., 2012) regularnie wykazują nieprawidłowe funkcjonowanie w ADHD. Chociaż struktury te w dużej mierze nie zostały ocenione pod kątem nieprawidłowości sensorycznych, można wywnioskować, że mogą być zaangażowane w nieprawidłowe przetwarzanie sensoryczne w ADHD ze względu na ich połączenia z układami sensorycznymi, ich rolę w funkcjach wyższego rzędu, takich jak przewidywanie, hamowanie, reaktywność emocjonalna, przetwarzanie czasowe, integracja multisensoryczna i filtrowanie sensoryczne oraz ich prawdopodobny udział w dysfunkcjach sensorycznych w innych zaburzeniach. takich jak ASD. Co więcej, wzgórek górny (SC), który jest ważny dla integracji sensorycznej, wydaje się funkcjonować nietypowo u osób z ADHD (Panagiotidi i in., 2017). Możliwe jest, że problemy z integracją sygnałów z wielu modalności sensorycznych w pniu mózgu mogą prowadzić do dalszych nieprawidłowości w przetwarzaniu multisensorycznym na wyższych poziomach przetwarzania.
Połączenia funkcjonalne związane z przetwarzaniem sensorycznym w ADHD
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Przetwarzanie w ADHD - Oprócz zmian w strukturach, łączność między tymi regionami mózgu może być nieprawidłowa w ADHD. Na przykład wykazano, że funkcjonalna łączność między ciałem migdałowatym a korą czołową, a także czołowo-skroniowo-potyliczną, jest upośledzona i związana z nieuwagą i nadpobudliwością w ADHD (Cocchi i in., 2012). Wewnętrzne sieci mózgowe na dużą skalę, takie jak sieć trybu domyślnego (DMN), sieć istotności (SN) i centralna sieć wykonawcza (CEN), wydają się funkcjonować inaczej u uczestników z ADHD (Cao i in., 2014; Carmona i in., 2015; Pereira i in., 2016). Jak wspomniano w powyższej sekcji dotyczącej ASD, dysfunkcja któregokolwiek lub wszystkich koncentratorów lub ich połączeń sieciowych może prowadzić do deficytów przetwarzania sensorycznego w ADHD.Innym wzorcem przetwarzania sensorycznego, który został zauważony w ADHD, jest tendencja do przetwarzania lokalnego i globalnego. Ta skłonność może być wspierana przez lokalną hiperłączność, ze zmniejszonymi połączeniami dalekiego zasięgu w całym mózgu (Cao i in., 2014; Cocchi i in., 2012). Na przykład Ahmadlou, Adeli i Adeli (2012) stwierdzili, że uczestnicy z ADHD wykazywali wysokie wzajemne połączenia między strukturami mózgu, ale charakterystyczna długość silnych połączeń była bardzo krótka. Wykazano, że DMN ma zmniejszoną łączność przednio-tylną u osób z ADHD (Cao i in., 2014). W kilku badaniach przedstawiono obrazowanie tensora dyfuzji (DTI; tj. integralność drogi istoty białej) dowody na nieprawidłową łączność w ADHD. Na przykład Cao i in. (2013) wykazali słabą łączność globalną z wysokim stopniem łączności lokalnej, co teoretycznie wiąże się z podobnymi deficytami funkcjonalnymi. Ponadto Hong i in., (2014) dostarczyli dowodów DTI na niedostateczną łączność między regionami czołowymi, prążkowiowymi i móżdżkiem, które prawdopodobnie można uznać za połączenia dalekiego zasięgu. Ogólnie rzecz biorąc, osoby z ADHD wydają się być bardzo narażone na nieprawidłowości sensoryczne, które mają tendencję do podążania za pewnymi wzorcami przetwarzania sensorycznego, które wydają się być pośredniczone przez dysfunkcję struktur podkorowych i korowych, a także ich połączeń.
Połączenia funkcjonane związane z przetwarzaniem sensorycznym w ADHD
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Jednym z wzorców nieprawidłowości przetwarzania sensorycznego, który został zbadany w ADHD (i ASD), jest przeciążenie sensoryczne (Micoulaud-Franchi i in., 2015). Oznacza to, że wiele osób z ADHD często czuje się przytłoczonych ciągłą stymulacją sensoryczną, wynikającą z trudności w odfiltrowaniu niechcianych sygnałów i zwracaniu uwagi na istotne lub pożądane bodźce (MicoulaudFranchi i in., 2015). Tego typu wyzwanie z pewnością może przyczynić się do nieuwagi i nadpobudliwości. Niektórzy twierdzą, że takie deficyty mogą być podłożone upośledzeniem bramkowania czuciowego, prawdopodobnie pośredniczonym przez dysfunkcję zwojów podstawy w ADHD (Holstein i in., 2013; Micoulaud-Franchi i in., 2015; Sable i in., 2012).
Bramkowanie sensoryczne (integracja?) w ADHD związane ze zwojami podstawy
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Na przykład kilku badaczy przedstawiło neurofizjologiczne dowody na nieprawidłowości w korowych potencjałach wywołanych wzrokowych, które były związane zarówno z wczesnym wzrokowym przetwarzaniem sensorycznym, jak i późniejszym przetwarzaniem uwagi, takim jak filtrowanie, orientacja i hamowanie odpowiedzi (Kemner i in., 1996; Nazari i in., 2010; Perchet i inni, 2001; Woestenburg i inni, 1992; Yong-Liang i inni, 2000). Ponadto wykazano zwiększoną aktywność mózgu w stanie spoczynku u nastolatków z ADHD, w porównaniu z grupą kontrolną dopasowaną do wieku, w pierwotnej lub wtórnej korze wzrokowej, słuchowej i somatosensorycznej oraz wzgórzu przez Tian i in., (2008). Odkrycia takie jak te sugerują, że specyficzna dla zmysłów kora i miejsca podkorowe są prawdopodobnie w pewnym stopniu zaangażowane w nieprawidłowe przetwarzanie sensoryczne w ADHD.
Neuronalne korelaty deficytów sensorycznych w ADHD
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Heterogeniczna prezentacja nieprawidłowości czuciowych w ADHD sugeruje, że supramodalne regiony mózgu są również zaangażowane w te objawy. Na przykład przerzedzenie kory mózgowej zostało zaproponowane jako marker ADHD (Narr i in., 2009). Podczas gdy kora asocjacyjna, w której zachodzi duża integracja sensoryczna, wykazywała ścieńczenie kory, pierwszorzędowe regiony czuciowe miały w dużej mierze typową grubość, co sugeruje neuronalny korelat upośledzenia integracji multisensorycznej w ADHD. Ponadto obszary, które są połączone z układami sensorycznymi i mają tendencję do modulacyjnego wpływu na korę czuciową, takie jak móżdżek (Cao, Shu, Cao, Wang i He, 2014; Czerkasowa i Hechtman, 2009; Davis i in., 2009; Goetz i in., 2014; Hong i in., 2014; Uddin i in., 2017), zwoje podstawy (Di Martino i in., 2013; Hong i in., 2014; Pereira i in., 2016), kora czołowa (Hong i in., 2014; Pereira i in., 2016; Uddin i in., 2017) i ciało migdałowate (Cocchi i in., 2012) regularnie wykazują nieprawidłowe funkcjonowanie w ADHD. Chociaż struktury te w dużej mierze nie zostały ocenione pod kątem nieprawidłowości sensorycznych, można wywnioskować, że mogą być zaangażowane w nieprawidłowe przetwarzanie sensoryczne w ADHD ze względu na ich połączenia z układami sensorycznymi, ich rolę w funkcjach wyższego rzędu, takich jak przewidywanie, hamowanie, reaktywność emocjonalna, przetwarzanie czasowe, integracja multisensoryczna i filtrowanie sensoryczne oraz ich prawdopodobny udział w dysfunkcjach sensorycznych w innych zaburzeniach. takich jak ASD. Co więcej, wzgórek górny (SC), który jest ważny dla integracji sensorycznej, wydaje się funkcjonować nietypowo u osób z ADHD (Panagiotidi i in., 2017). Możliwe jest, że problemy z integracją sygnałów z wielu modalności sensorycznych w pniu mózgu mogą prowadzić do dalszych nieprawidłowości w przetwarzaniu multisensorycznym na wyższych poziomach przetwarzania.
Neuronalne korelaty deficytów sensorycznych w ADHD
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teachbooks.tudelft.nl teachbooks.tudelft.nl
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flooding of coastal regions
Bedoel je hier t.g.v. overstromingen vanuit zee, of door hoogwater op de grote rivieren?
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or
as well as
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The
"The" kan weg.
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due
has not increased due
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there has been no increase in
weghalen.
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a storm flood
storm surges
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the
"the" weglaten.
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will not
is not expected to
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The
"The" weglaten. Dus "Future projections ...".
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the
"the" kan weg.
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are together
together are
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Watermanagementcentrum Nederland
Water Management Centre Netherlands
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The
"The" kan weg.
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.
, during which more than 1,800 people lost their lives.
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Northwest
Northwesterly
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related
due
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stormfloods
storm surges
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Local file Local file
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He came like a protecting spirit to the poor girl, who committed herselfto his care; and after the interment of his friend, he conducted her toGeneva, and placed her under the protection of a relation. Two yearsafter this event Caroline became his wife
WHAT
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Caroline Beaufort
oh i know her name
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Instead, Victoris described as “the victim” —not the perpetrator—of evil in his reviewof Frankenstein,
oh thats scary
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In order for mother to liveon through daughter, daughter must produce a work that meets thespectacular standards of Wollstonecraft’s biggest supporters, herself, andthe grieving love of her life, her father. The work must also compensatefor Mary’s horrific crime: the murder of her namesake. Mary probablywished that she, like Victor, might find out how to bestow life on deadthings; she must have also suffered from nightmares like his vision of“the corpse of my dead mother ... I saw the grave-worms crawling in thefolds of the flannel” (pp. 51-52).
OH THATS INSANE
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Reading the book, werealize that Frankenstein‘s lack of recognizing the creature as his own—in essence, not giving the monster his name—is the monster’s rootproblem. Is it our instinctive human sympathy for the anonymous beingthat has influenced us to name him? Is it our recognition of similaritiesand ties between “father” and “son,” our defensiveness regarding familyvalues? Or is it simply our interest in convenience, our compelling needto label and sort?
robin and lovell...
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teachbooks.tudelft.nl teachbooks.tudelft.nl
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.
, which caused more than 200 casualties and billions worth of material damage in the region.
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precipitation deficit
Leg uit hoe dat neerslagtekort precies wordt berekend, d.w.z. over welke periode in het jaar.
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, and these
Nieuwe zin: ". These ...".
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The
"The" kan weg.
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the
"the" kan weg.
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Below
Moeten die twee figuren niet genummerd worden?
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significantly
strongly ("significantly" heeft ook een statistische betekenis, die hier niet bedoeld wordt)
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surplus
surplus in a given year
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constant
constant from one year to the next
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teachbooks.tudelft.nl teachbooks.tudelft.nl
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water is
where water levels are
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Replenishment
Ik denk dat "recharge" een meer gebruikelijke term is, hier en in de rest van deze alinea.
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could be made
are available
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hydro-geology
Ik zou dit als een (1) woord schrijven, dus zonder verbindingsstreepje.
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teachbooks.tudelft.nl teachbooks.tudelft.nl
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Meuse
Meuse river bed
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significant elevation drop
relatively steep slope
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water to quickly flow into the river
the river basin to respond quickly to precipitation
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dry up
voeg toe "completely" na "dry up".
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teachbooks.tudelft.nl teachbooks.tudelft.nl
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remain
remained
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