- Jun 2022
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elifesciences.org elifesciences.org
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RRID:Addgene_179427
DOI: 10.7554/eLife.75115
Resource: RRID:Addgene_179427
Curator: @scibot
SciCrunch record: RRID:Addgene_179427
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RRID:Addgene_179425
DOI: 10.7554/eLife.75115
Resource: RRID:Addgene_179425
Curator: @scibot
SciCrunch record: RRID:Addgene_179425
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RRID:Addgene_179440
DOI: 10.7554/eLife.75115
Resource: RRID:Addgene_179440
Curator: @scibot
SciCrunch record: RRID:Addgene_179440
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RRID:Addgene_179439
DOI: 10.7554/eLife.75115
Resource: RRID:Addgene_179439
Curator: @scibot
SciCrunch record: RRID:Addgene_179439
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RRID:Addgene_179438
DOI: 10.7554/eLife.75115
Resource: RRID:Addgene_179438
Curator: @scibot
SciCrunch record: RRID:Addgene_179438
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elifesciences.org elifesciences.org
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RRID:SCR_008394
DOI: 10.7554/eLife.66909
Resource: Python Programming Language (RRID:SCR_008394)
Curator: @scibot
SciCrunch record: RRID:SCR_008394
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RRID:SCR_001622
DOI: 10.7554/eLife.66909
Resource: MATLAB (RRID:SCR_001622)
Curator: @scibot
SciCrunch record: RRID:SCR_001622
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RRID:SCR_001905
DOI: 10.7554/eLife.66909
Resource: R Project for Statistical Computing (RRID:SCR_001905)
Curator: @scibot
SciCrunch record: RRID:SCR_001905
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RRID:SCR_006513
DOI: 10.7554/eLife.66909
Resource: MethylSeekR (RRID:SCR_006513)
Curator: @scibot
SciCrunch record: RRID:SCR_006513
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RRID:SCR_005807
DOI: 10.7554/eLife.66909
Resource: GREAT: Genomic Regions Enrichment of Annotations Tool (RRID:SCR_005807)
Curator: @scibot
SciCrunch record: RRID:SCR_005807
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RRID:SCR_015687
DOI: 10.7554/eLife.66909
Resource: DESeq2 (RRID:SCR_015687)
Curator: @scibot
SciCrunch record: RRID:SCR_015687
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RRID:SCR_012918
DOI: 10.7554/eLife.66909
Resource: DiffBind (RRID:SCR_012918)
Curator: @scibot
SciCrunch record: RRID:SCR_012918
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RRID:SCR_010843
DOI: 10.7554/eLife.66909
Resource: SICER (RRID:SCR_010843)
Curator: @scibot
SciCrunch record: RRID:SCR_010843
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RRID:SCR_002105
DOI: 10.7554/eLife.66909
Resource: Samtools (RRID:SCR_002105)
Curator: @scibot
SciCrunch record: RRID:SCR_002105
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RRID:SCR_021323
DOI: 10.7554/eLife.66909
Resource: ENCODE Transcription Factor and Histone ChIP-Seq processing pipeline (RRID:SCR_021323)
Curator: @scibot
SciCrunch record: RRID:SCR_021323
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RRID:SCR_010881
DOI: 10.7554/eLife.66909
Resource: HOMER (RRID:SCR_010881)
Curator: @scibot
SciCrunch record: RRID:SCR_010881
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RRID:SCR_016368
DOI: 10.7554/eLife.66909
Resource: Bowtie (RRID:SCR_005476)
Curator: @scibot
SciCrunch record: RRID:SCR_016368
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RRID:SCR_006646
DOI: 10.7554/eLife.66909
Resource: BEDTools (RRID:SCR_006646)
Curator: @scibot
SciCrunch record: RRID:SCR_006646
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RRID:SCR_006525
DOI: 10.7554/eLife.66909
Resource: Picard (RRID:SCR_006525)
Curator: @scibot
SciCrunch record: RRID:SCR_006525
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RRID:SCR_010910
DOI: 10.7554/eLife.66909
Resource: BWA (RRID:SCR_010910)
Curator: @scibot
SciCrunch record: RRID:SCR_010910
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RRID:SCR_001876
DOI: 10.7554/eLife.66909
Resource: GATK (RRID:SCR_001876)
Curator: @scibot
SciCrunch record: RRID:SCR_001876
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RRID:SCR_016884
DOI: 10.7554/eLife.66909
Resource: clusterProfiler (RRID:SCR_016884)
Curator: @scibot
SciCrunch record: RRID:SCR_016884
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RRID:SCR_012802
DOI: 10.7554/eLife.66909
Resource: edgeR (RRID:SCR_012802)
Curator: @scibot
SciCrunch record: RRID:SCR_012802
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RRID:SCR_013027
DOI: 10.7554/eLife.66909
Resource: RSEM (RRID:SCR_013027)
Curator: @scibot
SciCrunch record: RRID:SCR_013027
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RRID:SCR_004463
DOI: 10.7554/eLife.66909
Resource: rna-star (RRID:SCR_004463)
Curator: @scibot
SciCrunch record: RRID:SCR_004463
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RRID:SCR_011841
DOI: 10.7554/eLife.66909
Resource: cutadapt (RRID:SCR_011841)
Curator: @scibot
SciCrunch record: RRID:SCR_011841
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RRID:SCR_011847
DOI: 10.7554/eLife.66909
Resource: Trim Galore (RRID:SCR_011847)
Curator: @scibot
SciCrunch record: RRID:SCR_011847
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RRID:SCR_014583
DOI: 10.7554/eLife.66909
Resource: FastQC (RRID:SCR_014583)
Curator: @scibot
SciCrunch record: RRID:SCR_014583
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RRID:SCR_014289
DOI: 10.7554/eLife.66909
Resource: ANY-maze (RRID:SCR_014289)
Curator: @scibot
SciCrunch record: RRID:SCR_014289
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RRID:SCR_014296
DOI: 10.7554/eLife.66909
Resource: MED Associates Activity Monitor software (RRID:SCR_014296)
Curator: @scibot
SciCrunch record: RRID:SCR_014296
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RRID:SCR_002716
DOI: 10.7554/eLife.66909
Resource: Synapse Web Reconstruct (RRID:SCR_002716)
Curator: @scibot
SciCrunch record: RRID:SCR_002716
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RRID:SCR_011323
DOI: 10.7554/eLife.66909
Resource: pClamp (RRID:SCR_011323)
Curator: @scibot
SciCrunch record: RRID:SCR_011323
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RRID:SCR_002184
DOI: 10.7554/eLife.66909
Resource: Mini Analysis Program (RRID:SCR_002184)
Curator: @scibot
SciCrunch record: RRID:SCR_002184
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RRID:AB_2337188
DOI: 10.7554/eLife.66909
Resource: (Jackson ImmunoResearch Labs Cat# 015-000-003, RRID:AB_2337188)
Curator: @scibot
SciCrunch record: RRID:AB_2337188
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RRID:AB_2561016
DOI: 10.7554/eLife.66909
Resource: (Active Motif Cat# 39133, RRID:AB_2561016)
Curator: @scibot
SciCrunch record: RRID:AB_2561016
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RRID:AB_2636821
DOI: 10.7554/eLife.66909
Resource: (Active Motif Cat# 39156, RRID:AB_2636821)
Curator: @scibot
SciCrunch record: RRID:AB_2636821
Tags
- RRID:SCR_005807
- RRID:SCR_012802
- RRID:SCR_021323
- RRID:SCR_014583
- RRID:SCR_016884
- RRID:SCR_001622
- RRID:SCR_010881
- RRID:SCR_014289
- RRID:SCR_011847
- RRID:AB_2636821
- RRID:SCR_010843
- RRID:SCR_001876
- RRID:SCR_006525
- RRID:SCR_002716
- RRID:SCR_004463
- RRID:SCR_014296
- RRID:SCR_008394
- RRID:SCR_012918
- RRID:AB_2561016
- RRID:AB_2337188
- RRID:SCR_006513
- RRID:SCR_016368
- RRID:SCR_010910
- RRID:SCR_001905
- RRID:SCR_002105
- RRID:SCR_011323
- RRID:SCR_015687
- RRID:SCR_011841
- RRID:SCR_002184
- RRID:SCR_013027
- RRID:SCR_006646
Annotators
URL
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elifesciences.org elifesciences.org
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RRID:AB_2492288
DOI: 10.7554/eLife.76886
Resource: (Jackson ImmunoResearch Labs Cat# 711-605-152, RRID:AB_2492288)
Curator: @scibot
SciCrunch record: RRID:AB_2492288
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RRID:AB_2340667
DOI: 10.7554/eLife.76886
Resource: (Jackson ImmunoResearch Labs Cat# 712-165-153, RRID:AB_2340667)
Curator: @scibot
SciCrunch record: RRID:AB_2340667
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RRID:AB_2340375
DOI: 10.7554/eLife.76886
Resource: (Jackson ImmunoResearch Labs Cat# 703-545-155, RRID:AB_2340375)
Curator: @scibot
SciCrunch record: RRID:AB_2340375
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RRID:AB_2202792
DOI: 10.7554/eLife.76886
Resource: (Novus Cat# NB100-74555, RRID:AB_1049988)
Curator: @scibot
SciCrunch record: RRID:AB_1049988
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RRID:AB_2536611
DOI: 10.7554/eLife.76886
Resource: (Thermo Fisher Scientific Cat# M11217, RRID:AB_2536611)
Curator: @scibot
SciCrunch record: RRID:AB_2536611
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RRID:AB_390204
DOI: 10.7554/eLife.76886
Resource: (Millipore Cat# AB152, RRID:AB_390204)
Curator: @scibot
SciCrunch record: RRID:AB_390204
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RRID:AB_10000240
DOI: 10.7554/eLife.76886
Resource: (Aves Labs Cat# GFP-1020, RRID:AB_10000240)
Curator: @scibot
SciCrunch record: RRID:AB_10000240
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RRID:IMSR_JAX:006660
DOI: 10.7554/eLife.76886
Resource: (IMSR Cat# JAX_006660,RRID:IMSR_JAX:006660)
Curator: @scibot
SciCrunch record: RRID:IMSR_JAX:006660
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elifesciences.org elifesciences.org
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BDSC:44588
DOI: 10.7554/eLife.78110
Resource: RRID:BDSC_44588
Curator: @scibot
SciCrunch record: RRID:BDSC_44588
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BDSC:44589
DOI: 10.7554/eLife.78110
Resource: (BDSC Cat# 44589,RRID:BDSC_44589)
Curator: @scibot
SciCrunch record: RRID:BDSC_44589
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BDSC:51056
DOI: 10.7554/eLife.78110
Resource: (BDSC Cat# 51056,RRID:BDSC_51056)
Curator: @scibot
SciCrunch record: RRID:BDSC_51056
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BDSC:91222
DOI: 10.7554/eLife.78110
Resource: RRID:BDSC_91222
Curator: @scibot
SciCrunch record: RRID:BDSC_91222
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BDSC:55134
DOI: 10.7554/eLife.78110
Resource: (BDSC Cat# 55134,RRID:BDSC_55134)
Curator: @scibot
SciCrunch record: RRID:BDSC_55134
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BDSC:81246
DOI: 10.7554/eLife.78110
Resource: (BDSC Cat# 81246,RRID:BDSC_81246)
Curator: @scibot
SciCrunch record: RRID:BDSC_81246
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BDSC:57668
DOI: 10.7554/eLife.78110
Resource: (BDSC Cat# 57668,RRID:BDSC_57668)
Curator: @scibot
SciCrunch record: RRID:BDSC_57668
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BDSC:57669
DOI: 10.7554/eLife.78110
Resource: (BDSC Cat# 57669,RRID:BDSC_57669)
Curator: @scibot
SciCrunch record: RRID:BDSC_57669
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RRID:SCR_002234
DOI: 10.7554/eLife.78110
Resource: Computational Morphometry Toolkit (RRID:SCR_002234)
Curator: @scibot
SciCrunch record: RRID:SCR_002234
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RRID:SCR_003032
DOI: 10.7554/eLife.78110
Resource: Cytoscape (RRID:SCR_003032)
Curator: @scibot
SciCrunch record: RRID:SCR_003032
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RRID:SCR_002798
DOI: 10.7554/eLife.78110
Resource: GraphPad Prism (RRID:SCR_002798)
Curator: @scibot
SciCrunch record: RRID:SCR_002798
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RRID:SCR_014300
DOI: 10.7554/eLife.78110
Resource: SlideBook (RRID:SCR_014300)
Curator: @scibot
SciCrunch record: RRID:SCR_014300
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RRID:SCR_018315
DOI: 10.7554/eLife.78110
Resource: Jupyter Notebook (RRID:SCR_018315)
Curator: @scibot
SciCrunch record: RRID:SCR_018315
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RRID:SCR_008394
DOI: 10.7554/eLife.78110
Resource: Python Programming Language (RRID:SCR_008394)
Curator: @scibot
SciCrunch record: RRID:SCR_008394
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RRID:SCR_017248
DOI: 10.7554/eLife.78110
Resource: NeuroAnatomy Toolbox (RRID:SCR_017248)
Curator: @scibot
SciCrunch record: RRID:SCR_017248
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RRID:SCR_001905
DOI: 10.7554/eLife.78110
Resource: R Project for Statistical Computing (RRID:SCR_001905)
Curator: @scibot
SciCrunch record: RRID:SCR_001905
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RRID:SCR_006278
DOI: 10.7554/eLife.78110
Resource: CATMAID (RRID:SCR_006278)
Curator: @scibot
SciCrunch record: RRID:SCR_006278
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RRID:SCR_002285
DOI: 10.7554/eLife.78110
Resource: Fiji (RRID:SCR_002285)
Curator: @scibot
SciCrunch record: RRID:SCR_002285
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RRID:AB_2535805
DOI: 10.7554/eLife.78110
Resource: (Thermo Fisher Scientific Cat# A-21236, RRID:AB_2535805)
Curator: @scibot
SciCrunch record: RRID:AB_2535805
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RRID:AB_10563566
DOI: 10.7554/eLife.78110
Resource: (Thermo Fisher Scientific Cat# A-11036, RRID:AB_10563566)
Curator: @scibot
SciCrunch record: RRID:AB_10563566
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RRID:AB_2534096
DOI: 10.7554/eLife.78110
Resource: (Thermo Fisher Scientific Cat# A-11039, RRID:AB_2534096)
Curator: @scibot
SciCrunch record: RRID:AB_2534096
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RRID:AB_2576217
DOI: 10.7554/eLife.78110
Resource: (Thermo Fisher Scientific Cat# A-11034, RRID:AB_2576217)
Curator: @scibot
SciCrunch record: RRID:AB_2576217
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RRID:AB_10013483
DOI: 10.7554/eLife.78110
Resource: (Takara Bio Cat# 632496, RRID:AB_10013483)
Curator: @scibot
SciCrunch record: RRID:AB_10013483
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RRID:AB_2534023
DOI: 10.7554/eLife.78110
Resource: (Thermo Fisher Scientific Cat# A10262, RRID:AB_2534023)
Curator: @scibot
SciCrunch record: RRID:AB_2534023
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RRID:AB_221569
DOI: 10.7554/eLife.78110
Resource: (Molecular Probes Cat# A-11122, RRID:AB_221569)
Curator: @scibot
SciCrunch record: RRID:AB_221569
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RRID:AB_2314866
DOI: 10.7554/eLife.78110
Resource: (DSHB Cat# nc82, RRID:AB_2314866)
Curator: @scibot
SciCrunch record: RRID:AB_2314866
Tags
- RRID:SCR_002798
- RRID:SCR_006278
- RRID:BDSC_81246
- RRID:AB_2535805
- RRID:AB_2534023
- RRID:BDSC_57668
- RRID:BDSC_57669
- RRID:BDSC_51056
- RRID:BDSC_44588
- RRID:AB_221569
- RRID:AB_2314866
- RRID:SCR_002285
- RRID:SCR_002234
- RRID:BDSC_55134
- RRID:AB_10563566
- RRID:SCR_017248
- RRID:SCR_008394
- RRID:BDSC_91222
- RRID:BDSC_44589
- RRID:SCR_003032
- RRID:AB_2576217
- RRID:SCR_018315
- RRID:SCR_001905
- RRID:SCR_014300
- RRID:AB_2534096
- RRID:AB_10013483
Annotators
URL
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elifesciences.org elifesciences.org
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Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Molecularly, grey hairs upregulate proteins related to energy metabolism, mitochondria, and antioxidant defenses. Combining HPP profiling and proteomics on single hairs, we also report hair greying and reversal that can occur in parallel with psychological stressors. To generalize these observations, we develop a computational simulation, which suggests a threshold-based mechanism for the temporary reversibility of greying.
https://elifesciences.org/articles/67437
Researchers have shown that some types of greying hair are reversible.
Tags
Annotators
URL
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- May 2022
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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RRID: 2336883
DOI: 10.7554/eLife.71845
Resource: (Takara Bio Cat# 632592, RRID:AB_2336883)
Curator: @bandrow
SciCrunch record: RRID:AB_2336883
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RRID:AB_143165
DOI: 10.7554/eLife.71845
Resource: (Thermo Fisher Scientific Cat# A-11008, RRID:AB_143165)
Curator: @scibot
SciCrunch record: RRID:AB_143165
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RRID:AB_310177
DOI: 10.7554/eLife.71845
Resource: (Millipore Cat# 06-570, RRID:AB_310177)
Curator: @scibot
SciCrunch record: RRID:AB_310177
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RRID:AB_444313
DOI: 10.7554/eLife.71845
Resource: (Abcam Cat# ab18197, RRID:AB_444313)
Curator: @scibot
SciCrunch record: RRID:AB_444313
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RRID:AB_2535844
DOI: 10.7554/eLife.71845
Resource: (Thermo Fisher Scientific Cat# A-21422, RRID:AB_2535844)
Curator: @scibot
SciCrunch record: RRID:AB_2535844
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- Apr 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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DGRC: ): https://dgrc.bio.indiana.edu/product/View?product=1568
DOI: 10.7554/eLife.67598
Resource: RRID:DGRC_1568
Curator: @bandrow
SciCrunch record: RRID:DGRC_1568
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Annotators
URL
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elifesciences.org elifesciences.org
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DANDI: Distributed Archives for Neurophysiology Data Integration
DOI: 10.7554/eLife.55130
Resource: Distributed Archives for Neurophysiology Data Integration (RRID:SCR_017571)
Curator: @bandrow
SciCrunch record: RRID:SCR_017571
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URL
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elifesciences.org elifesciences.org
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https://gui.dandiarchive.org
DOI: 10.7554/eLife.61834
Resource: Distributed Archives for Neurophysiology Data Integration (RRID:SCR_017571)
Curator: @bandrow
SciCrunch record: RRID:SCR_017571
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Annotators
URL
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elifesciences.org elifesciences.org
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https://nemoarchive.org/
DOI: 10.7554/eLife.68802
Resource: NeMOarchive (RRID:SCR_016152)
Curator: @bandrow
SciCrunch record: RRID:SCR_016152
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Annotators
URL
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elifesciences.org elifesciences.org
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https://assets.nemoarchive.org
DOI: 10.7554/eLife.73520
Resource: NeMOarchive (RRID:SCR_016152)
Curator: @bandrow
SciCrunch record: RRID:SCR_016152
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Annotators
URL
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- Mar 2022
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elifesciences.org elifesciences.org
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RRID:NXR_0
DOI: 10.7554/eLife.33549
Resource: (NXR Cat# 0080,RRID:NXR_0080)
Curator: @evieth
SciCrunch record: RRID:NXR_0080
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- Feb 2022
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elifesciences.org elifesciences.org
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2019-10-25
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10.7554/eLife.51230
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The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V RBDs in complex with human aminopeptidase N (hAPN), as well as the electron cryomicroscopy structure of the 229E S-protein. The structures show that common core interactions define the specificity for hAPN and that the peripheral RBD sequence variation is accommodated by loop plasticity. The results provide insight into immune evasion and the cross-species transmission of 229E and related coronaviruses. We also find that the 229E S-protein can expose a portion of its helical core to solvent. This is undoubtedly facilitated by hydrophilic subunit interfaces that we show are conserved among coronaviruses. These interfaces likely play a role in the S-protein conformational changes associated with membrane fusion.
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The human coronavirus HCoV-229E S-protein structure and receptor binding
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elifesciences.org elifesciences.org
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RRID:SCR_002798
DOI: 10.7554/eLife.35224
Resource: GraphPad Prism (RRID:SCR_002798)
Curator: @scibot
SciCrunch record: RRID:SCR_002798
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RRID:SCR_014199
DOI: 10.7554/eLife.35224
Resource: Adobe Photoshop (RRID:SCR_014199)
Curator: @scibot
SciCrunch record: RRID:SCR_014199
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RRID:SCR_002285
DOI: 10.7554/eLife.35224
Resource: Fiji (RRID:SCR_002285)
Curator: @scibot
SciCrunch record: RRID:SCR_002285
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RRID:SCR_002677
DOI: 10.7554/eLife.35224
Resource: AxioVision Imaging System (RRID:SCR_002677)
Curator: @scibot
SciCrunch record: RRID:SCR_002677
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RRID:AB_10679369
DOI: 10.7554/eLife.35224
Resource: (Abcam Cat# ab97051, RRID:AB_10679369)
Curator: @scibot
SciCrunch record: RRID:AB_10679369
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RRID:AB_305564
DOI: 10.7554/eLife.35224
Resource: (Abcam Cat# ab6556, RRID:AB_305564)
Curator: @scibot
SciCrunch record: RRID:AB_305564
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RRID:SCR_014485
DOI: 10.7554/eLife.35224
Resource: MaxQuant (RRID:SCR_014485)
Curator: @scibot
SciCrunch record: RRID:SCR_014485
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RRID:SCR_013731
DOI: 10.7554/eLife.35224
Resource: National Xenopus Resource (RRID:SCR_013731)
Curator: @scibot
SciCrunch record: RRID:SCR_013731
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elifesciences.org elifesciences.org
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B2086
DOI: 10.7554/eLife.02996
Resource: A Resource Center For Tetrahymena Thermophila (RRID:SCR_008362)
Curator: @Naa003
SciCrunch record: RRID:SCR_008362
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CU428
DOI: 10.7554/eLife.02996
Resource: A Resource Center For Tetrahymena Thermophila (RRID:SCR_008362)
Curator: @Naa003
SciCrunch record: RRID:SCR_008362
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CU427
DOI: 10.7554/eLife.02996
Resource: A Resource Center For Tetrahymena Thermophila (RRID:SCR_008362)
Curator: @Naa003
SciCrunch record: RRID:SCR_008362
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B2086
DOI: 10.7554/eLife.02996
Resource: A Resource Center For Tetrahymena Thermophila (RRID:SCR_008362)
Curator: @Naa003
SciCrunch record: RRID:SCR_008362
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CU428
DOI: 10.7554/eLife.02996
Resource: A Resource Center For Tetrahymena Thermophila (RRID:SCR_008362)
Curator: @Naa003
SciCrunch record: RRID:SCR_008362
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CU427
DOI: 10.7554/eLife.02996
Resource: A Resource Center For Tetrahymena Thermophila (RRID:SCR_008362)
Curator: @Naa003
SciCrunch record: RRID:SCR_008362
Tags
Annotators
URL
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- Jan 2022
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elifesciences.org elifesciences.org
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RRID:CVCL_C464
DOI: 10.7554/eLife.69584
Resource: (ATCC Cat# CRL-4003, RRID:CVCL_C464)
Curator: @scibot
SciCrunch record: RRID:CVCL_C464
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RRID:AB_141359
DOI: 10.7554/eLife.69584
Resource: (Molecular Probes Cat# A-11012, RRID:AB_141359)
Curator: @scibot
SciCrunch record: RRID:AB_141359
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RRID:AB_2633218
DOI: 10.7554/eLife.69584
Resource: (Thermo Fisher Scientific Cat# 720256, RRID:AB_2633218)
Curator: @scibot
SciCrunch record: RRID:AB_2633218
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RRID:SCR_006786
DOI: 10.7554/eLife.69584
Resource: WebGestalt: WEB-based GEne SeT AnaLysis Toolkit (RRID:SCR_006786)
Curator: @scibot
SciCrunch record: RRID:SCR_006786
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RRID:SCR_016339
DOI: 10.7554/eLife.69584
Resource: Monocle2 (RRID:SCR_016339)
Curator: @scibot
SciCrunch record: RRID:SCR_016339
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RRID:SCR_007322
DOI: 10.7554/eLife.69584
Resource: SEURAT (RRID:SCR_007322)
Curator: @scibot
SciCrunch record: RRID:SCR_007322
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RRID:SCR_011950
DOI: 10.7554/eLife.69584
Resource: vegan (RRID:SCR_011950)
Curator: @scibot
SciCrunch record: RRID:SCR_011950
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RRID:SCR_017254
DOI: 10.7554/eLife.69584
Resource: IQ-TREE (RRID:SCR_017254)
Curator: @scibot
SciCrunch record: RRID:SCR_017254
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RRID:SCR_016582
DOI: 10.7554/eLife.69584
Resource: kallisto (RRID:SCR_016582)
Curator: @scibot
SciCrunch record: RRID:SCR_016582
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elifesciences.org elifesciences.org
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The 53 papers selected for replication in the RP:CB.
Hey lets look at these papers
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elifesciences.org elifesciences.org
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Such opportunities and challenges, best illustrated during the pandemic, lie ahead as medicine moves towards the goal of providing evidence-based care to patients no matter where they live. This trajectory also opens up real opportunities for speed, transparency and rich evaluation across peer review in medicine.
呼吁医学界提供更为快速、透明、评估更为全面的同行评审创造需求
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But even as the pandemic has demonstrated the potential for rapid, author-driven publication to democratize access and accelerate research, it has exposed the challenges of this model of scholarly communication
作者驱动的快速出版 面向大众开放 促进研究
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usher
展示 更快的 更广泛的 更开放的
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- Dec 2021
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elifesciences.org elifesciences.org
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plasmid_46757
DOI: 10.7554/eLife.72345
Resource: RRID:Addgene_46757
Curator: @scibot
SciCrunch record: RRID:Addgene_46757
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plasmid_42250
DOI: 10.7554/eLife.72345
Resource: RRID:Addgene_42250
Curator: @scibot
SciCrunch record: RRID:Addgene_42250
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plasmid_122562
DOI: 10.7554/eLife.72345
Resource: RRID:Addgene_122562
Curator: @scibot
SciCrunch record: RRID:Addgene_122562
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plasmid_122563
DOI: 10.7554/eLife.72345
Resource: RRID:Addgene_122563
Curator: @scibot
SciCrunch record: RRID:Addgene_122563
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Plasmid_42
DOI: 10.7554/eLife.72345
Resource: RRID:Addgene_42
Curator: @scibot
SciCrunch record: RRID:Addgene_42
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RRID:ZFIN_ZDB-GENO-180802-1
DOI: 10.7554/eLife.72345
Resource: (ZFIN Cat# ZDB-GENO-180802-1,RRID:ZFIN_ZDB-GENO-180802-1)
Curator: @scibot
SciCrunch record: RRID:ZFIN_ZDB-GENO-180802-1
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RRID:ZFIN_ZDB-GENO-071217-3
DOI: 10.7554/eLife.72345
Resource: (ZFIN Cat# ZDB-GENO-071217-3,RRID:ZFIN_ZDB-GENO-071217-3)
Curator: @scibot
SciCrunch record: RRID:ZFIN_ZDB-GENO-071217-3
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RRID:ZFIN_ZDB-GENO-100504-13
DOI: 10.7554/eLife.72345
Resource: (ZFIN Cat# ZDB-GENO-100504-13,RRID:ZFIN_ZDB-GENO-100504-13)
Curator: @scibot
SciCrunch record: RRID:ZFIN_ZDB-GENO-100504-13
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Plasmid_122
DOI: 10.7554/eLife.72345
Resource: RRID:Addgene_122562
Curator: @Naa003
SciCrunch record: RRID:Addgene_122562
Curator comments: pGEM-T Easy-Gbait-hs-Cre
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elifesciences.org elifesciences.org
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RRID:SCR_002798
DOI: 10.7554/eLife.62432
Resource: GraphPad Prism (RRID:SCR_002798)
Curator: @scibot
SciCrunch record: RRID:SCR_002798
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RRID:SCR_008520
DOI: 10.7554/eLife.62432
Resource: FlowJo (RRID:SCR_008520)
Curator: @scibot
SciCrunch record: RRID:SCR_008520
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RRID:AB_1107619
DOI: 10.7554/eLife.62432
Resource: (Bio X Cell Cat# BE0012, RRID:AB_1107619)
Curator: @scibot
SciCrunch record: RRID:AB_1107619
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RRID:AB_1107636
DOI: 10.7554/eLife.62432
Resource: (Bio X Cell Cat# BE0003-1, RRID:AB_1107636)
Curator: @scibot
SciCrunch record: RRID:AB_1107636
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RRID:AB_1107705
DOI: 10.7554/eLife.62432
Resource: (Bio X Cell Cat# BE0043-1, RRID:AB_1107705)
Curator: @scibot
SciCrunch record: RRID:AB_1107705
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RRID:AB_1107702
DOI: 10.7554/eLife.62432
Resource: (Bio X Cell Cat# BE0043, RRID:AB_1107702)
Curator: @scibot
SciCrunch record: RRID:AB_1107702
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RRID:AB_1107694
DOI: 10.7554/eLife.62432
Resource: (Bio X Cell Cat# BE0055, RRID:AB_1107694)
Curator: @scibot
SciCrunch record: RRID:AB_1107694
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RRID:AB_467135
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 14-0161-86, RRID:AB_467135)
Curator: @scibot
SciCrunch record: RRID:AB_467135
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RRID:AB_466193
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 12-7311-82, RRID:AB_466193)
Curator: @scibot
SciCrunch record: RRID:AB_466193
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RRID:AB_465936
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 12-5773-82, RRID:AB_465936)
Curator: @scibot
SciCrunch record: RRID:AB_465936
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RRID:AB_466199
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 12-7321-82, RRID:AB_466199)
Curator: @scibot
SciCrunch record: RRID:AB_466199
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RRID:AB_394341
DOI: 10.7554/eLife.62432
Resource: (BD Biosciences Cat# 552126, RRID:AB_394341)
Curator: @scibot
SciCrunch record: RRID:AB_394341
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RRID:AB_2562503
DOI: 10.7554/eLife.62432
Resource: (BioLegend Cat# 145406, RRID:AB_2562503)
Curator: @scibot
SciCrunch record: RRID:AB_2562503
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RRID:AB_1937317
DOI: 10.7554/eLife.62432
Resource: (BD Biosciences Cat# 560776, RRID:AB_1937317)
Curator: @scibot
SciCrunch record: RRID:AB_1937317
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RRID:AB_10611860
DOI: 10.7554/eLife.62432
Resource: (BD Biosciences Cat# 561236, RRID:AB_10611860)
Curator: @scibot
SciCrunch record: RRID:AB_10611860
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RRID:AB_394587
DOI: 10.7554/eLife.62432
Resource: (BD Biosciences Cat# 553052, RRID:AB_394587)
Curator: @scibot
SciCrunch record: RRID:AB_394587
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RRID:AB_1937327
DOI: 10.7554/eLife.62432
Resource: (BD Biosciences Cat# 560783, RRID:AB_1937327)
Curator: @scibot
SciCrunch record: RRID:AB_1937327
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RRID:AB_1937314
DOI: 10.7554/eLife.62432
Resource: (BD Biosciences Cat# 560771, RRID:AB_1937314)
Curator: @scibot
SciCrunch record: RRID:AB_1937314
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RRID:AB_10563910
DOI: 10.7554/eLife.62432
Resource: (BD Biosciences Cat# 561226, RRID:AB_10563910)
Curator: @scibot
SciCrunch record: RRID:AB_10563910
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RRID:AB_1272189
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 48-0453-82, RRID:AB_1272189)
Curator: @scibot
SciCrunch record: RRID:AB_1272189
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RRID:AB_2573992
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 47-5932-82, RRID:AB_2573992)
Curator: @scibot
SciCrunch record: RRID:AB_2573992
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RRID:AB_465232
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 11-5321-82, RRID:AB_465232)
Curator: @scibot
SciCrunch record: RRID:AB_465232
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RRID:AB_469398
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 17-0453-82, RRID:AB_469398)
Curator: @scibot
SciCrunch record: RRID:AB_469398
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RRID:AB_10671550
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 48-0251-82, RRID:AB_10671550)
Curator: @scibot
SciCrunch record: RRID:AB_10671550
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RRID:AB_469366
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 17-0251-82, RRID:AB_469366)
Curator: @scibot
SciCrunch record: RRID:AB_469366
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RRID:AB_464950
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 11-0141-85, RRID:AB_464950)
Curator: @scibot
SciCrunch record: RRID:AB_464950
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RRID:AB_1582236
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 48-0112-82, RRID:AB_1582236)
Curator: @scibot
SciCrunch record: RRID:AB_1582236
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RRID:AB_1107004
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 45-0081-82, RRID:AB_1107004)
Curator: @scibot
SciCrunch record: RRID:AB_1107004
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RRID:AB_1272193
DOI: 10.7554/eLife.62432
Resource: (Thermo Fisher Scientific Cat# 48-0032-82, RRID:AB_1272193)
Curator: @scibot
SciCrunch record: RRID:AB_1272193
Tags
- RRID:AB_464950
- RRID:AB_1582236
- RRID:SCR_002798
- RRID:AB_1272193
- RRID:AB_2562503
- RRID:AB_1107702
- RRID:AB_394341
- RRID:AB_1107694
- RRID:AB_466193
- RRID:AB_394587
- RRID:AB_2573992
- RRID:AB_1937314
- RRID:AB_467135
- RRID:AB_1937317
- RRID:AB_1107636
- RRID:AB_469366
- RRID:AB_466199
- RRID:SCR_008520
- RRID:AB_10563910
- RRID:AB_1272189
- RRID:AB_465232
- RRID:AB_1107004
- RRID:AB_469398
- RRID:AB_10611860
- RRID:AB_1107619
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- RRID:AB_1107705
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URL
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elifesciences.org elifesciences.org
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RRID:SCR_002865
DOI: 10.7554/eLife.70137
Resource: SPSS (RRID:SCR_002865)
Curator: @scibot
SciCrunch record: RRID:SCR_002865
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RRID:SCR_002798
DOI: 10.7554/eLife.70137
Resource: GraphPad Prism (RRID:SCR_002798)
Curator: @scibot
SciCrunch record: RRID:SCR_002798
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RRID:SCR_001622
DOI: 10.7554/eLife.70137
Resource: MATLAB (RRID:SCR_001622)
Curator: @scibot
SciCrunch record: RRID:SCR_001622
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RRID:IMSR_JAX:006852
DOI: 10.7554/eLife.70137
Resource: (IMSR Cat# JAX_006852,RRID:IMSR_JAX:006852)
Curator: @scibot
SciCrunch record: RRID:IMSR_JAX:006852
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- Nov 2021
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elifesciences.org elifesciences.org
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it is designed to help institutional leaders reflect on the extent to which their organization can support sustained and values-driven assessment practices, and where they might focus efforts to further evolve them.
SPACE to support sustained and values-driven assessment practices.
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SPACE is a rubric that is composed of two axes
adaptation to Indonesian institutes
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prioritize rankings over their stated goals for diversity, equity, and inclusion
prioritize rankings over other missions
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the metric oversimplification of scholarly achievement distracts academics and institutions
metric oversimplification >> distractions
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Rather, it is due to a growing reliance on proxy measures of research quality in the management of recruitment, promotion, tenure and funding decisions: these proxy measures are widely used because they are convenient, not because they are meaningful. The pursuit of a higher ranking in league tables for universities has also contributed to the problem.
proxy measures >> convenient but not meaningful
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Ghent University in Belgium made headlines in 2019 when it announced a new policy for evaluating faculty that marked a shift away from the 'rat race' of metrics and rankings towards more holistic processes focused on valuing and nurturing talent
notice >> rat race
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- Sep 2021
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elifesciences.org elifesciences.org
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However, the entire repair process for DSBs is notably more efficient in DR than in other organisms; DR is able to restore hundreds of copies of damaged double strands in an hour
I guess that answers my last question, but raises another question: what allows the repair process to only be most efficient in DR than other organisms, could there be some other important aspect involved in the mechanism?
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The first binding between drRecO and ssDNA occurs in the drSSB-free space of ssDNA and generates a heterotrimer of the drSSB-ssDNA-drRecO complex as an intermediate state. The second binding between drRecO and ssDNA induces the dissociation of drSSB from ssDNA by facilitating a conformational change in ssDNA.
So ultimately from these findings there are two steps involved in a conformational change in the ssDNA and can avoid using ATP?
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molecular mechanism of D. radiodurans (DR) RecO (drRecO) in SSB displacement from ssDNA at the single-molecule level. DR is the toughest bacterium known, with outstanding resistance to ionizing radiation and DNA damage-inducing reagents (Blasius et al., 2008; Cox and Battista, 2005; Slade and Radman, 2011), which are the main causes of DSBs, a form of fatal biological damage at the genomic level
I wonder if a section of the genome that helps encode for this mechanism and trait for resistance to ionizing radiation can be inserted in other organisms or be used to prevent DNA damage from radiation
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In summary, our results demonstrate that drRecO binds to ssDNA sequentially using its two binding sites, which gives drRecO the ability to displace drSSB from ssDNA even though the binding affinity of drRecO for ssDNA is two orders of magnitude smaller than that of drSSB.
It is amazing that cells are capable of performing actions like this and the researchers were able to show this through their results. I would usually assume that a molecule would need a stronger binding affinity to displace another bound protein, so it was interesting to learn how DrRecO can accomplish this with a much lower binding affinity.
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RecO is believed to play a key role in this step because RecO is able to interact with SSB, ssDNA, and dsDNA simultaneously
So (if I'm interpreting this correctly) RecO is thought to be involved in helping to recruit the rest of the RecFOR machinery to the site of the break because it can interact with SSB, ssDNA, and dsDNA even though SSB binds strongly to ssDNA, right?
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- Aug 2021
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elifesciences.org elifesciences.org
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RRID:AB_10861977
DOI: 10.7554/eLife.70564
Resource: (Abcam Cat# ab113687, RRID:AB_10861977)
Curator: @scibot
SciCrunch record: RRID:AB_10861977
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RRID:AB_303395
DOI: 10.7554/eLife.70564
Resource: (Abcam Cat# ab290, RRID:AB_303395)
Curator: @scibot
SciCrunch record: RRID:AB_303395
Tags
Annotators
URL
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elifesciences.org elifesciences.org
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RRID:Addgene_113005
DOI: 10.7554/eLife.67294
Resource: RRID:Addgene_113005
Curator: @scibot
SciCrunch record: RRID:Addgene_113005
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RRID:AB_10015282
DOI: 10.7554/eLife.67294
Resource: (Jackson ImmunoResearch Labs Cat# 711-035-152, RRID:AB_10015282)
Curator: @scibot
SciCrunch record: RRID:AB_10015282
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RRID:AB_2338133
DOI: 10.7554/eLife.67294
Resource: (Jackson ImmunoResearch Labs Cat# 112-035-062, RRID:AB_2338133)
Curator: @scibot
SciCrunch record: RRID:AB_2338133
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RRID:AB_2338510
DOI: 10.7554/eLife.67294
Resource: (Jackson ImmunoResearch Labs Cat# 115-035-164, RRID:AB_2338510)
Curator: @scibot
SciCrunch record: RRID:AB_2338510
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RRID:AB_2340447
DOI: 10.7554/eLife.67294
Resource: (Jackson ImmunoResearch Labs Cat# 706-035-148, RRID:AB_2340447)
Curator: @scibot
SciCrunch record: RRID:AB_2340447
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RRID:AB_2568986
DOI: 10.7554/eLife.67294
Resource: (Nakamura A; Development. 2001 Cat# me31B, RRID:AB_2568986)
Curator: @scibot
SciCrunch record: RRID:AB_2568986
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RRID:AB_10598029
DOI: 10.7554/eLife.67294
Resource: (MBL International Cat# PM013-7, RRID:AB_10598029)
Curator: @scibot
SciCrunch record: RRID:AB_10598029
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RRID:AB_528189
DOI: 10.7554/eLife.67294
Resource: (DSHB Cat# F2F4, RRID:AB_528189)
Curator: @scibot
SciCrunch record: RRID:AB_528189
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RRID:BDSC_4274
DOI: 10.7554/eLife.67294
Resource: (BDSC Cat# 4274,RRID:BDSC_4274)
Curator: @scibot
SciCrunch record: RRID:BDSC_4274
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RRID:BDSC_6839
DOI: 10.7554/eLife.67294
Resource: (BDSC Cat# 6839,RRID:BDSC_6839)
Curator: @scibot
SciCrunch record: RRID:BDSC_6839
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RRID:BDSC_24163
DOI: 10.7554/eLife.67294
Resource: (BDSC Cat# 24163,RRID:BDSC_24163)
Curator: @scibot
SciCrunch record: RRID:BDSC_24163
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RRID:BDSC_38437
DOI: 10.7554/eLife.67294
Resource: (BDSC Cat# 38437,RRID:BDSC_38437)
Curator: @scibot
SciCrunch record: RRID:BDSC_38437
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RRID:BDSC_3248
DOI: 10.7554/eLife.67294
Resource: (BDSC Cat# 3248,RRID:BDSC_3248)
Curator: @scibot
SciCrunch record: RRID:BDSC_3248
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RRID:DGGR_110658
DOI: 10.7554/eLife.67294
Resource: (DGGR Cat# 110658,RRID:DGGR_110658)
Curator: @scibot
SciCrunch record: RRID:DGGR_110658
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elifesciences.org elifesciences.org
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RRID:SCR_002798
DOI: 10.7554/eLife.68268
Resource: GraphPad Prism (RRID:SCR_002798)
Curator: @scibot
SciCrunch record: RRID:SCR_002798
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RRID:BDSC_18896
DOI: 10.7554/eLife.68268
Resource: (BDSC Cat# 18896,RRID:BDSC_18896)
Curator: @scibot
SciCrunch record: RRID:BDSC_18896
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RRID:BDSC_24819
DOI: 10.7554/eLife.68268
Resource: (BDSC Cat# 24819,RRID:BDSC_24819)
Curator: @scibot
SciCrunch record: RRID:BDSC_24819
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RRID:BDSC_56254
DOI: 10.7554/eLife.68268
Resource: (BDSC Cat# 56254,RRID:BDSC_56254)
Curator: @scibot
SciCrunch record: RRID:BDSC_56254
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RRID:BDSC_8765
DOI: 10.7554/eLife.68268
Resource: (BDSC Cat# 8765,RRID:BDSC_8765)
Curator: @scibot
SciCrunch record: RRID:BDSC_8765
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RRID:BDSC_5905
DOI: 10.7554/eLife.68268
Resource: (BDSC Cat# 5905,RRID:BDSC_5905)
Curator: @scibot
SciCrunch record: RRID:BDSC_5905
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elifesciences.org elifesciences.org
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RRID:Addgene_12253
DOI: 10.7554/eLife.64148
Resource: RRID:Addgene_12253
Curator: @scibot
SciCrunch record: RRID:Addgene_12253
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RRID:AB_2875675
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 751690, RRID:AB_2875675)
Curator: @scibot
SciCrunch record: RRID:AB_2875675
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RRID:AB_2875614
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 751621, RRID:AB_2875614)
Curator: @scibot
SciCrunch record: RRID:AB_2875614
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RRID:AB_394629
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 553108, RRID:AB_394629)
Curator: @scibot
SciCrunch record: RRID:AB_394629
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RRID:AB_394806
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 553355, RRID:AB_394806)
Curator: @scibot
SciCrunch record: RRID:AB_394806
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RRID:AB_394774
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 553310, RRID:AB_394774)
Curator: @scibot
SciCrunch record: RRID:AB_394774
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RRID:AB_394595
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 553062, RRID:AB_394595)
Curator: @scibot
SciCrunch record: RRID:AB_394595
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RRID:AB_396936
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 557915, RRID:AB_396936)
Curator: @scibot
SciCrunch record: RRID:AB_396936
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RRID:AB_394618
DOI: 10.7554/eLife.64148
Resource: (BD Biosciences Cat# 553088, RRID:AB_394618)
Curator: @scibot
SciCrunch record: RRID:AB_394618
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