483 Matching Annotations
  1. Jun 2023
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    Upf3a is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
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    biorxiv.org/content/10.1101/2022.07.04.495064v2
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    Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases
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    biorxiv.org/content/10.1101/2023.01.02.522462v1
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    The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
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    biorxiv.org/content/10.1101/2022.08.19.504520v1
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    Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function
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    biorxiv.org/content/10.1101/2022.12.11.519953v2
  6. May 2023
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    BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer
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    biorxiv.org/content/10.1101/2021.07.15.452487v2
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    Recursive splicing discovery using lariats in total RNA sequencing
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    biorxiv.org/content/10.1101/2022.12.22.521701v1
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    Exploratory Meta-Analysis of Hypoxic Transcriptomes Using a Precise Transcript Reference Sequence Set
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    biorxiv.org/content/10.1101/2022.05.01.489280v2
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    VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome
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    biorxiv.org/content/10.1101/2022.03.16.484566v1
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    Telescoping bimodal latent Dirichlet allocation to identify expression QTLs across tissues
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    biorxiv.org/content/10.1101/2021.10.27.466156v2
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    RAS and PP2A activities converge on epigenetic gene regulation
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    biorxiv.org/content/10.1101/2022.05.11.491459v1
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    Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
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    biorxiv.org/content/10.1101/2022.05.09.491247v1
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    Gapless provides combined scaffolding, gap filling and assembly correction with long reads
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    biorxiv.org/content/10.1101/2022.03.08.483466v2
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    Z-Flipon Variants reveal the many roles of Z-DNA and Z-RNA in health and disease
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    biorxiv.org/lookup/doi/10.1101/2023.01.12.523822
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    The value of genotype-specific reference for transcriptome analyses
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    biorxiv.org/content/10.1101/2021.09.14.460213v1
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    Genome-wide CRISPRi screening reveals regulators of Alzheimee's tau pathology shared between exosomal and vesicle-free tau seeds.
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    biorxiv.org/content/10.1101/2022.04.26.489622v1
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    Small non-coding vault RNA1-2 modulate expression of cell membrane proteins through nascent RNA silencing
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    biorxiv.org/content/10.1101/2022.08.12.503724v2
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    LuminoCell: a versatile and affordable luminometer platform for monitoring in-cell luciferase-based reporters
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    biorxiv.org/content/10.1101/2022.01.28.478134v1
  20. Apr 2023
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    Efficient knock-in method enabling lineage tracing in zebrafish
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    biorxiv.org/content/10.1101/2022.07.15.500272v1
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    The TUDOR domain of SMN is an H3K79me1 histone mark reader
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    biorxiv.org/content/10.1101/2022.10.06.511070v1
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    Preference of CAMSAP3 for microtubules with expanded lattice contributes to stabilization of the minus end
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    biorxiv.org/content/10.1101/2022.08.21.504720v2
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    Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
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    biorxiv.org/content/10.1101/2022.08.15.503960v1
  25. Mar 2023
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    Peroxisomes contribute to intracellular calcium dynamics
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    biorxiv.org/content/10.1101/2020.09.02.279174v1
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    An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum
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    biorxiv.org/content/10.1101/2021.03.12.435157v2
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    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
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    biorxiv.org/content/10.1101/2021.11.30.470499v1
  29. www.biorxiv.org www.biorxiv.org
    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation, epithelial repair, and tumor growth
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    biorxiv.org/content/10.1101/2022.04.11.487842v1
  30. www.biorxiv.org www.biorxiv.org
    Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
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    biorxiv.org/content/10.1101/2021.10.03.462949v4
  31. www.biorxiv.org www.biorxiv.org
    Lack of peroxisomal catalase affects heat shock response in C. elegans
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    biorxiv.org/content/10.1101/2021.07.13.452156v1
  32. www.biorxiv.org www.biorxiv.org
    Lineage Tracing Reveals Fate Bias and Transcriptional Memory in Human B cells
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    biorxiv.org/content/10.1101/2022.07.14.499766v2
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    Critical roles of ICOS in controlling Foxp3-expressing T follicular cell subsets during early-stage germinal center reactions
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    biorxiv.org/content/10.1101/2021.09.14.460384v2
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    The human MRS2 magnesium binding domain is a regulatory feedback switch for channel activity.
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    biorxiv.org/content/10.1101/2022.09.27.509701v1
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    Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
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    biorxiv.org/content/10.1101/2022.02.18.481032v1
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    Segregation of pathways leading to pexophagy
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    biorxiv.org/content/10.1101/2022.11.08.515582v1
  37. www.biorxiv.org www.biorxiv.org
    New algorithms for accurate and efficient de-novo genome assembly from long DNA sequencing reads
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    biorxiv.org/content/10.1101/2022.08.30.505891v1
  38. Feb 2023
  39. www.biorxiv.org www.biorxiv.org
    Adenylyl cyclase 9 is auto-stimulated by its isoform-specific carboxyl terminal domain and equipped with paradigm-switching mechanisms.
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    biorxiv.org/content/10.1101/2022.06.05.494885v3
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    Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
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    biorxiv.org/content/10.1101/2022.05.16.492085v1
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    SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology
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    biorxiv.org/content/10.1101/2022.07.26.501499v1
  42. www.biorxiv.org www.biorxiv.org
    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
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    biorxiv.org/content/10.1101/2021.09.20.461067v1
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    Human RNA Nm-MTase FTSJ1: new tRNA targets and role in the regulation of brain-specific genes.
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    biorxiv.org/content/10.1101/2021.02.06.430044v4
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    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
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    biorxiv.org/content/10.1101/2022.09.08.507072v1
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    Epigenetic signals that direct cell type specific interferon beta response in mouse cells
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    biorxiv.org/content/10.1101/2022.02.26.481127v1
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    Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae
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    biorxiv.org/content/10.1101/2021.07.31.454568v1
  47. Jan 2023
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    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
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    biorxiv.org/content/10.1101/2022.06.02.494495v2
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    Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
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    biorxiv.org/content/10.1101/2022.08.31.506132v1
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    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.
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    biorxiv.org/content/10.1101/2022.02.13.480288v1
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    Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells
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    biorxiv.org/content/10.1101/2022.09.07.506974v1
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    Identifying novel regulators of placental development using time series transcriptomic data and network analyses
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    biorxiv.org/content/10.1101/2022.05.17.492330v1
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    De novo discovery of traits co-occurring with chronic obstructive pulmonary disease
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    biorxiv.org/content/10.1101/2022.07.20.500731v1
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    An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation
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    biorxiv.org/content/10.1101/2022.07.01.498448v1
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    Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.03.04.483068v3
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    A synergistic activation of RARb and RARg nuclear receptors restores cell-types specialization during stem cells differentiation by hijacking RARa-controlled program
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    biorxiv.org/content/10.1101/2022.05.31.494116v2
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    Nuclear envelope reshaping around the vacuole determines the morphology of the ribosomal DNA
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    biorxiv.org/content/10.1101/2021.06.23.449658v1
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    Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.01.09.475571v1
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    Sibling rivalry among the ZBTB transcription factor family: homo vs. heterodimers
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    biorxiv.org/content/10.1101/2021.12.17.472994v2
  60. Dec 2022
  61. www.biorxiv.org www.biorxiv.org
    Stage-specific gene and transcript dynamics in human male germ cells
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    biorxiv.org/content/10.1101/2022.03.22.485121v1
  62. earthcommission.org earthcommission.org
    New Earth Commission Working Group to Focus on the Challenges of Cross-Scale Translation - Earth Commission
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    earthcommission.org/news/earth-commission-news/new-earth-commission-working-group-to-focus-on-the-challenges-of-cross-scale-translation/
  63. www.biorxiv.org www.biorxiv.org
    Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing
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    biorxiv.org/content/10.1101/2022.06.08.495310v1
  64. www.biorxiv.org www.biorxiv.org
    Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
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    biorxiv.org/content/10.1101/2022.05.14.491942v1
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    Genome-wide Profiling of Histone Modifications in Plasmodium falciparum using CUT&RUN.
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    biorxiv.org/content/10.1101/2022.08.01.502378v2
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    Systematic analysis of ADP-ribose detection reagents and optimisation of sample preparation to detect ADP-ribosylation in vitro and in cells
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    biorxiv.org/content/10.1101/2022.02.22.481411v1
  67. www.biorxiv.org www.biorxiv.org
    Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
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    biorxiv.org/content/10.1101/2022.08.12.503771v2
  68. Nov 2022
  69. www.biorxiv.org www.biorxiv.org
    Actin binding domain of Rng2 strongly inhibits actin movement on myosin II HMM through structural changes of actin filaments
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    biorxiv.org/content/10.1101/2020.04.14.041046v4
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    Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex
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    biorxiv.org/content/10.1101/2022.05.13.491728v1
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    Improving the computation efficiency of polygenic risk score modeling: Faster in Julia
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    biorxiv.org/content/10.1101/2021.12.27.474263v1
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    Structure of mammalian V-ATPase with the TLDc domain protein mEAK7 bound
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    biorxiv.org/content/10.1101/2021.11.03.466369v2
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    Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish
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    biorxiv.org/content/10.1101/2021.12.22.473872v1
  74. Oct 2022
  75. www.biorxiv.org www.biorxiv.org
    https://biorxiv.org/cgi/content/10.1101/2022.03.06.483172
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    biorxiv.org/content/10.1101/2022.03.06.483172v1
  76. www.biorxiv.org www.biorxiv.org
    Replication-associated inversions are the dominant form of bacterial chromosome structural variation
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    biorxiv.org/content/10.1101/2022.02.15.480581v1
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    Contribution of the Golgi apparatus in morphogenesis of a virus induced cytopathic vacuolar system
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    biorxiv.org/content/10.1101/2022.03.14.484265v1
  78. www.biorxiv.org www.biorxiv.org
    Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain
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    biorxiv.org/content/10.1101/2022.04.21.489014v1
  79. www.biorxiv.org www.biorxiv.org
    Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
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    biorxiv.org/content/10.1101/2022.04.03.486870v1
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    Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor
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    biorxiv.org/content/10.1101/2021.11.30.470689v1
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    Evaluation of CA repeat arrays as targets for MeCP2 function in the brain
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    biorxiv.org/content/10.1101/2022.04.26.489598v2
  82. Sep 2022
  83. www.biorxiv.org www.biorxiv.org
    Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein level changes
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    biorxiv.org/content/10.1101/2022.02.24.481857v1
  84. www.biorxiv.org www.biorxiv.org
    Human gene function publications that describe wrongly identified nucleotide sequence reagents are unacceptably frequent within the genetics literature
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    biorxiv.org/content/10.1101/2021.07.29.453321v1
  85. Aug 2022
  86. www.biorxiv.org www.biorxiv.org
    Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy
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    biorxiv.org/content/10.1101/2020.11.14.382861v1
  87. www.biorxiv.org www.biorxiv.org
    Islet Gene View - a tool to facilitate islet research
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    biorxiv.org/content/10.1101/435743v3
  88. www.biorxiv.org www.biorxiv.org
    Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis
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    biorxiv.org/content/10.1101/2022.05.02.490246v1
  89. www.biorxiv.org www.biorxiv.org
    CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids
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    biorxiv.org/content/10.1101/2021.07.20.453105v2
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    A minimal hepatocyte growth factor mimic acting as a powerful agonist of the MET receptor tyrosine kinase for regeneration of epithelial tissues and organs.
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    biorxiv.org/content/10.1101/2020.07.20.212654v3
  91. www.biorxiv.org www.biorxiv.org
    Drosophila insulator proteins exhibit in-vivo liquid-liquid phase separation properties
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    biorxiv.org/content/10.1101/2022.05.27.493687v1
  92. www.biorxiv.org www.biorxiv.org
    ScRNA-seq Expression of APOC2 and IFI27 Identifies Four Families of Alveolar Macrophage Superclusters in Cystic Fibrosis and Healthy BALF
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    biorxiv.org/content/10.1101/2022.01.30.478325v3
  93. www.biorxiv.org www.biorxiv.org
    ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
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    biorxiv.org/content/10.1101/2021.12.22.473898v2
  94. Jul 2022
  95. www.biorxiv.org www.biorxiv.org
    LncRNA RUS shapes the gene expression program towards neurogenesis
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    biorxiv.org/content/10.1101/2022.02.17.480853v1
  96. Jun 2022
  97. www.civicsoftechnology.org www.civicsoftechnology.org
    Whose interests do teaching machines serve? — Civics of Technology
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    civicsoftechnology.org/blog/whose-interests-do-teaching-machines-serve
  98. www.biorxiv.org www.biorxiv.org
    Negative curvature-promoting lipids instruct nuclear ingression of low autophagic potential vacuoles
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    biorxiv.org/content/10.1101/2021.06.26.450031v1
  99. www.biorxiv.org www.biorxiv.org
    OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
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    biorxiv.org/content/10.1101/2021.04.21.440692v1
  100. www.biorxiv.org www.biorxiv.org
    Genetic and compound screens uncover factors modulating cancer cell response to indisulam
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  172. Jun 2021
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      G7 support for pharma monopolies is putting millions of lives at risk | Amnesty International. (n.d.). Retrieved June 12, 2021, from https://www.amnesty.org/en/latest/news/2021/06/g7-support-for-pharma-monopolies-putting-millions-of-lives-at-risk/

      is:webpage lang:en COVID-19 G7 G7 Leaders' Summit People's Vaccine Alliance vaccine government UK patent waiving resources campaign vaccine inequity inequity health inequality public health vaccine technology vaccine production funding COVAX pharmaceutical corporation supply finance intellectual property
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  174. May 2021
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  178. Apr 2021
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  189. Feb 2021
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    Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F
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    biorxiv.org/content/10.1101/2020.06.02.130047v1
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    Overlapping oriC and centromere-like functions in secondary genome replicons determine their maintenance independent of chromosome I in Deinococcus radiodurans
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    biorxiv.org/content/10.1101/2020.03.28.013953v1
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    Short duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy
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    biorxiv.org/content/10.1101/2020.08.17.253526v1
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    The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity
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    biorxiv.org/content/10.1101/2020.01.30.927731v1
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    Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast
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    biorxiv.org/content/10.1101/2020.05.30.125559v1
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    A double role of the Gal80 N-terminus in activation of transcription by Gal4p
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    biorxiv.org/content/10.1101/2020.02.03.931568v1
  205. Oct 2020
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    Predicting gene regulatory networks from cell atlases
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    biorxiv.org/content/10.1101/2020.08.21.261735v1
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    DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis
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    A meiosis-specific AAA+ assembly reveals repurposing of ORC during budding yeast gametogenesis
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    biorxiv.org/content/10.1101/598128v1
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    multicrispr: fast gRNA designer enables prime editing and parallel targeting of thousands of targets
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    biorxiv.org/content/10.1101/2020.04.15.042861v1
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    Profiles of circulating histidine-rich glycoprotein associate with age and risk of all-cause mortality
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    Peptide-based quorum sensing systems in Paenibacillus polymyxa
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    A time resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth
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    An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella
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    biorxiv.org/content/10.1101/2020.07.01.182683v1
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    Attenuation of cGAS/STING Activity During Mitosis
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    biorxiv.org/content/10.1101/2019.12.19.883090v2
  215. Jul 2020
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    An unexpected contribution of lincRNA splicing to enhancer function.
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    Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
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    Lipid-associated PML domains regulate CCTα, Lipin1 and lipid homeostasis
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    Mitochondrial fusion defects caused by CMT2A disease-associated variants of Mfn2
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    Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis
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    A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
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    Evaluation of colorectal cancer subtypes and cell lines using deep learning
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    Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling
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  224. Jun 2020
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    Plant-microbe co-evolution: allicin resistance in a Pseudomonas fluorescens strain (PfAR-1) isolated from garlic
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    Ubiquitin and SUMO conjugation as biomarkers of Acute Myeloid Leukemias response to chemotherapies
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    Dynamic changes in the regulatory T cell heterogeneity and function by murine IL-2 mutein
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    BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
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    The structure of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR-fold
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  230. Mar 2020
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    Towards a Technology of Solidarity: 10 lessons from Dd's first 10 years
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    1. almereyda 07 Mar 2020
      10. Ally is a Verb Solidarity is an ongoing process, and ally is a verb. Showing up in a good way is something we continually practice, not a destination where we arrive. This is not our unique insight - the concept of ally being a verb, not a noun, has a long history in social justice spaces, and it’s one worth highlighting. When we think of ourselves as “allies” (nouns) we can get complacent by thinking we have arrived, or we can get fragile when we make mistakes that make us question our status as “allies.” When instead we see ourselves as practicing allyship with frontline communities, then we recognize that our goal is to continually listen, learn from and take action in solidarity with our partners.
      alliance
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