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    Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12849641/
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    Rational design of an optimized ferritin nanoparticle vaccine targeting both SARS-CoV-2 and MERS-CoV
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    pmc.ncbi.nlm.nih.gov/articles/PMC13573459/
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    Stage-Dependent Effects of “Too Little and Too Much” Medial Prefrontal Activity on Reversal Learning in Rats: Functional Inhibition Impairs Early, Whereas Neural Disinhibition Impairs Late Reversals
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    pmc.ncbi.nlm.nih.gov/articles/PMC13560906/
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    RVG-targeted extracellular vesicles loaded with echinatin attenuate dopaminergic neurodegeneration via the IGF-2/PI3K/Akt pathway in Parkinson’s disease mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12870896/
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    A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13551691/
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    Heterosynaptic Interactions between the Dorsal and Ventral Hippocampus in Individual Medium Spiny Neurons of the Nucleus Accumbens Ventromedial Shell
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    pmc.ncbi.nlm.nih.gov/articles/PMC12981289/
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    CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12998327/
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    tRNA m2G methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13001353/
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    LncRNA RNF144A-AS1 increases P300-mediated H4K5 acetylation of PDE4 to promote keloid fibrosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011735/
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    Impacts of ketogenic diet intervention on cardiometabolic outcomes in obese, dysglycemic mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12866436/
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    Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12994253/
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    Induction of plant resistance to bean common mosaic virus (BCMV) via multiple applications of nanoparticle-conjugated dsRNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC12997905/
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    Human primordial germ cell heterogeneity in vitro is associated with distinctive biological states
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    pmc.ncbi.nlm.nih.gov/articles/PMC13560305/
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    G-quadruplex structures are key regulators of mammalian spermatogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12865992/
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    Germ line LCP1 mutations cause immunodeficiency with neutropenia, monocytopenia, lymphopenia, and defective cytokinesis
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    Semaphorin 7A Regulates the Balance Between Cartilaginous and Fibrous Tissues in the Repair Process of Articular Cartilage Damage
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    Endothelial deletion of the neddylation E2 enzyme UBE2M inhibits tumor growth by promoting nonproductive angiogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13574159/
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    Base editing rescues seizures and sudden death in a SCN8A mutation-associated developmental epileptic encephalopathy model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12871382/
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    TP53/TAU axis regulates microtubule bundling to control alveolar stem cell–mediated regeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC13038196/
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    Desmoplakin Mutations in Cardiac Fibroblasts Cause TGFβ1-Mediated Pathological Fibrogenesis in Desmoplakin Cardiomyopathy Via Beclin-1 Regulation
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    Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer
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    SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012622/
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    Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012031/
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    GPR39 activation inhibits AQP2 trafficking and alters cytoskeletal organization
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    The bacterial pH gradient contributes to persistence in Mycobacterium tuberculosis
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    A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC13556198/
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    NAT10 is critical to block RNA sensing-induced IFN-β transactivation in viral infection
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    The ORF6 accessory protein contributes to SARS-CoV-2 virulence and pathogenicity in the naturally susceptible feline model of infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011341/
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    Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13573833/
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    GSK3β and Plk1 sequentially phosphorylate ATP–citrate lyase to promote homologous recombination
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    pmc.ncbi.nlm.nih.gov/articles/PMC13557067/
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    Peroxiredoxin 1 safeguards the nucleolar genome from oxidative damage
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    Substrate heterogeneity promotes cancer cell dissemination through interface roughening
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    Dysregulated m6A via compensatory arginine methylation primes premalignancy in metabolic dysfunction–associated steatotic liver disease
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    Injury-induced electrochemical coupling triggers organ growth
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    Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis–dependent ferroptotic vulnerability
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    Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer
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    Self-inactivating AAV-CRISPR at different ages enables sustained amelioration of Huntington’s disease deficits in BAC226Q mice
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    Complementary cortical and thalamic contributions to cell type–specific striatal activity dynamics during movement
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    Hybrid female sterility due to cohesin protection errors in mouse oocytes
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    A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding
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    A damaging mutation in COL6A3 alters the mechanobiologic response of chondrocytes derived from human induced pluripotent stem cells
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    Dendritic Cell–Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12994126/
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    Strain, procedures, and tools for reproducible genetic transformation and genome editing of the emerging plant model Spirodela polyrhiza
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    pmc.ncbi.nlm.nih.gov/articles/PMC13001002/
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    Secondary Somatosensory Cortex Is Required for Learning but Not Execution of a Tactile Discrimination
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    pmc.ncbi.nlm.nih.gov/articles/PMC12853412/
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    Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
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    pmc.ncbi.nlm.nih.gov/articles/PMC12863257/
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    Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12829591/
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    SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS–STING
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    Development and characterization of pNarsenic: a naringenin-inducible biosensor for arsenic in Escherichia coli
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    Co-activation of the super-enhancer complex SOX2 and HDAC1 confers temozolomide resistance by promoting PDGFB transcription in glioblastoma
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    A prevalent disease-associated SNP in the human ID3 gene regulates E-protein activity and cellular proliferation
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    Conserved mRNP remodeling mechanism of the TREX-2.1 complex
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    B-type lamins maintain transcriptional homeostasis by spatially controlling chromatin–speckle proximity
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    Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1
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    m5C RNA methylation is dysregulated by oncogenic herpesviruses via c-Myc signaling to counteract host antiviral factors
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    Structural and functional insights into the adenosine deaminase of the type III-B CRISPR–Cas system
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    RSRC2 is a novel RNA-binding protein that safeguards mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12993456/
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    Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage
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    Fibrillarin/Nop1 perturbs RNA folding and assembly independently of liquid–liquid phase separation
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    LDB1 regulates gene expression and chromatin structure in pluripotency and lineage differentiation
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    AURKB-driven dissolution of CIZ1–RNA assemblies from the inactive X chromosome in mitosis
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    Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts
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    RABEP1 Regulates Neutrophil Migration via Endosomal Recycling and Actin Polymerization
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    USP34 attenuates cartilage degradation in temporomandibular joint osteoarthritis by ANT1-mediated mitophagy
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    Gene Editing of a Carcinogenic Liver Fluke Tetraspanin Impairs Parasite Surface Biogenesis and Extracellular Vesicle Uptake by Human Host Cells
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    Rhythmic Nuclear Import Mediated by Importins Regulates the Neurospora Circadian Clock
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    pmc.ncbi.nlm.nih.gov/articles/PMC13334116/
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    Regulated proteolysis of green fluorescent protein fusion proteins in Aspergillus fumigatus
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    CRISPR-Cas based plasmid design for multidrug-resistant Klebsiella pneumoniae isolates
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    pmc.ncbi.nlm.nih.gov/articles/PMC13032867/
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    Identification of optimal fluorophores for use in the Drosophila embryo
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    DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses
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    In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation
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    Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity
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    Activation of mTOR pathway by human cytomegalovirus promoting host ribosomal protein expression by coordinated transcriptional and translational controls
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    Advancing targeted protein degradation: pLIRTAC’s role in glioma and CAR-T cell therapy
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    Depletion of TECPR2 leads to mitochondrial failure associated with neurodegeneration
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    Disrupted autophagy overactivates TBK1 and results in mitotic defects promoting chromosomal instability
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    Glutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression
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    Reprogrammed SimCells for antimicrobial therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012131/
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    Intronic polyadenylation–derived long noncoding RNA modulates nucleolar integrity and function
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    Ubiquitin-specific peptidase-19 links TDP-43 aggregation to ER stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12994178/
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    Visual system function requires translational regulation of ATF4 by Hbs1-Pelo
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    pmc.ncbi.nlm.nih.gov/articles/PMC13554125/
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    Caspase-3 cleaves CYLD to restrict interferon signaling during mitochondrial apoptosis
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    Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1
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    Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope
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    Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast
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    pmc.ncbi.nlm.nih.gov/articles/PMC13022404/
  86. archimate.projects.opengroup.org archimate.projects.opengroup.org
    ArchiMate Beginners' Guide: A Practical Introduction
    1
    1. jbsarrodie 07 Oct 2026
      There are plenty of examples of Passive Structures in our "Body System"

      Explain that in this example, nested is used to suggest that Blood and Nutients are "inside" the body, while other passive structures are ultimately outside.

      JB

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    archimate.projects.opengroup.org/-/archimate-beginners-guide/-/jobs/277386/artifacts/public/index.html
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC13022133/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations
    3
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    pmc.ncbi.nlm.nih.gov/articles/PMC13035475/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12858408/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12858398/
  91. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13031129/
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular tension indicators reveal unexpectedly complex regulation of tension in live mouse organs
    6
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    pmc.ncbi.nlm.nih.gov/articles/PMC13031782/
  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation
    1
    1. scibot 07 Oct 2026
      AddGene protocol (https://www.addgene.org/protocols/plko/). In brief, short hairpin RNA (shRNA) sequences targeting Foxa3 (sense: 5’-TCCTTCGTCCACACCTTATTT-3’; antisense: 5’-AAATAAGGTGTGGACGAAGGA-3’) were synthesized (Sangon Biotech). pLKO.1-TRC

      DOI: 10.1038/s42003-026-09736-2

      Resource: RRID:Addgene_10878

      Curator: @AleksanderDrozdz

      SciCrunch record: RRID:Addgene_10878

      What is this?

      RRID:Addgene_10878
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    pmc.ncbi.nlm.nih.gov/articles/PMC13035940/
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models
    5
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    pmc.ncbi.nlm.nih.gov/articles/PMC13009348/
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural basis for bat receptor recognition by SARS-CoV-2 and bat SARS2-like coronaviruses
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13000228/
  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural variation drives enhancer hijacking via 3D genome disruption in ccRCC
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12852824/
  97. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Minigene-based characterization and classification of splice-associated variants in succinate dehydrogenase B
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13554259/
  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual engagement of Spike and ACE2 by annexin A5 contributes to pleiotropic SARS-CoV-2 inhibition
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13558681/
  99. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Long-term competition experiments reveal limited adaptive evolution in human cell lines
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC13554058/
  100. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LncRNA Dlx4os drives malignant transformation and phenotype switching in melanoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13003849/
  101. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRPF8-associated retinitis pigmentosa variant induces human neural retina-autonomous photoreceptor defects
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13031808/
  102. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Claudin18.2 promote gastric cancer proliferation by activating MCM2/5
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13031519/