1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis
    15
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    sciencedirect.com/science/article/pii/S1097276526002704
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    Region-resolved integrative multi-omic characterization reveals diverse tumor and microenvironment features of pituitary neuroendocrine tumors
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    sciencedirect.com/science/article/pii/S1535947626000794
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    Targeting DYRK1A with Harmine Abrogates the FOXO1-NF-κB Axis to Alleviate Cellular Senescence and Renal Fibrosis
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    sciencedirect.com/science/article/pii/S0047637426000369
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    Loss of GABAergic transmission from somatostatin neurons leads to starvation, which is attenuated by a palatable diet
    17
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    sciencedirect.com/science/article/pii/S002432052600264X
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    The gut microbiota regulates the protein corona formation, biodistribution, and cellular uptake of lipid nanoparticles
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    sciencedirect.com/science/article/pii/S0168365926003986
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    '-html.html
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    The key regulator circ_0003295 promotes arsenic-induced lung carcinogenesis and progression by enhancing mitochondrial function
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    sciencedirect.com/science/article/pii/S0147651326005622
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    HOXD11-NMDAR signaling drives neuroendocrine prostate cancer and enables potential therapeutic intervention as a target of memantine
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    sciencedirect.com/science/article/pii/S2211124726004080
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    Initial vaccination platform against S. pneumoniae shapes antibody profiles upon revaccination with pneumococcal conjugate vaccine in older adults
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    sciencedirect.com/science/article/pii/S2211124726004006
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    Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
    30
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    sciencedirect.com/science/article/pii/S0092867426004666
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    Galvanin (TMEM154) is an electric-field sensor for directed cell migration
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    Detachable TMSD-CRISPR for programmable and highly specific discrimination of DNA/RNA mutations
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    sciencedirect.com/science/article/pii/S1385894726047248
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    Cancer-linked ANKRD26-RET uses an unusual combination of pathomechanisms leading to strongly increased cell proliferation
    14
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  15. www.youtube.com www.youtube.com
    Video: The Future of Text 2017 Session 2. (DocDrop)
    2
    2. gyuri 13 May 2026
      The Future of Text 2017 Session 2.Tap to unmute2xThe Future of Text 2017 Session 2.Frode Hegland (Augmented Text) 264 views 8 years agoCopy linkInfoShoppingIf playback doesn't begin shortly, try restarting your device.Pull up for precise seekingPause4:39Introduction•You're signed outVideos you watch may be added to the TV's watch history and influence TV recommendations. To avoid this, cancel and sign in to YouTube on your computer.CancelConfirmUp nextLiveUpcomingCancelPlay NowShareInclude playlistAn error occurred while retrieving sharing information. Please try again later.0:101:07 / 1:13:24Live•Watch full video•Introduction•Deep Focus - Music For Studying | Improve Your Focus - Study MusicGreenred Productions - Relaxing Music183 watching • 1 year agoLivePlaylist ()Mix (50+)Tranquil Jazz Lakeside Ambience For Deep Relaxing | Soft Jazz Music In Outdoor Coffee Shop To FocusQuiet Jazz Ambience1K watching • 5 months agoLivePlaylist ()Mix (50+)37:35Clara Mattei: capitalism is not natural - it’s enforcedChannel 4 News982K views • 2 months agoLivePlaylist ()Mix (50+)Deep Focus Music To Improve Concentration - 12 Hours of Ambient Study Music to Concentrate #858Relaxing Melody314 watching • 1 year agoLivePlaylist ()Mix (50+)1:05:09Gil Strang's Final 18.06 Linear Algebra LectureMIT OpenCourseWare3M views • Streamed 2 years agoLivePlaylist ()Mix (50+)36:05Should Computers Run the World? - with Hannah FryThe Royal Institution590K views • 7 years agoLivePlaylist ()Mix (50+)1:39:58Ruff Bálint: A legkeményebb korrupcióellenes szabályok lesznek, amit Magyarország valaha is látott444.hu245K views • 20 hours agoLivePlaylist ()Mix (50+)21:55Magyar Péter miniszterelnök; Vadhajtások, Orbán bibliája; Megszűnik a Tények; Az ország ünnepelPottyondy Edina389K views • 1 day agoLivePlaylist ()Mix (50+)1:49:55How To Speak Fluently In English About Almost AnythingEnglishAnyone4.2M views • Streamed 3 years agoLivePlaylist ()Mix (50+)Classical Piano To Study To | Mozart, Beethoven, Debussy, ChopinClassical Oasis166 watching • 1 year agoLivePlaylist ()Mix (50+)33:08How to Start Coding | Programming for Beginners | Learn Coding | IntellipaatIntellipaat11M views • Streamed 6 years agoLivePlaylist ()Mix (50+)36:03Magyar Péter beszéde a miniszterek parlamenti beiktatásánIndex.hu30K views • 13 hours agoLivePlaylist ()Mix (50+) The Future of Text 2017 Session 2.

      session 2

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  16. bafybeihwigujdzh7xrbwmf2t2zv5eku6cr3reb5qzqmhgrpnfdd2ryhh7y.ipfs.dweb.link bafybeihwigujdzh7xrbwmf2t2zv5eku6cr3reb5qzqmhgrpnfdd2ryhh7y.ipfs.dweb.link
    HyperePost | Future of Text Talk
    2
    1. indyweb 13 May 2026
      Who is doing the job of helping you to map the expanding frontier of your knowledgeparaphrased: Who is doing the job of creating a map of the Web frontier as you explore it. (200????) Or indeed a map of the territory already explored, ready to resume exactly where you left off.  How Hyperpost addresses these problemsDeep rearrangability and repurposabilty supported by a new "Cosmology for Computing' Capture Intertwingularity as scaffoldings of everything you care about in one placeAdd new capabilities at the Meta LevelHyperPost: The Thought Processor for Google+Google+: interest based social networking serviceSocial Knowledge Network: Intersection of Knowledge Graph, Google+ Circles and Thought GraphsGoogle+: interest based social networking serviceCircles: entire saffolding: Vannevar Bush: American electrical engineer and science administratorMemex: hypothetical proto-hypertext system that Vannevar Bush described in 1945HyperPost: The Thought Processor for Google+trails: Trail blazing: StubMemex: hypothetical proto-hypertext system that Vannevar Bush described in 1945Connected neighborhoods of nodes thus conveyed contain not only the information presented in the narrative trails, but they also contain as it were the entire scaffolding  with which they were erected.  Trail blazing  as in the  Memex  Thought Vectors in Concept Space  kernel for  tinkerable  Hypermedia Direct manipulation interfaces to suit personal needsthe Lively Kernel project.tinkerable: through associations: "The Human mind works by association" As We May Think - The Atlantickernel: main component of most computer operating systemsLively Kernel: StubDirect manipulation interface: StubHypermedia: Hypermedia, an extension of the term hypertext, is a nonlinear medium of information that includes graphics, audio, video, plain text and hyperlinks.To have sufficient built in capability in the  kernel  that support  tinkerable  Hypermedia formats incorporating Direct manipulation interfaces to suit personal needs, as it was done in the Lively Kernel project.  Thought Graph Search for Things as you writeThe sentences that you write are Nodes Structural linksHyperPost: The Thought Processor for Google+search and mention: entity: something that existswrite about things: Node: network conceptThought Graph: HyperPost  invites us to  search and mention  all the things that are important in the context of our thoughts that are related to the things we write about. The sentences you write down are turned into  Nodes in a  Thought Graph    Public Knowledge Graph Incorporate Entities from Google's Knowledge GraphWikiData auto suggest boxesThing: Wikidata: free knowledge database project hosted by Wikimedia and edited by volunteersPersonal Knowledge Graph: Google: American multinational Internet and technology corporationKnowledge Graph: knowledge base used by Google to enhance its search engine's search resultsWhen you want to mention some  Thing  the search box autosuggests matching entities drawn   Wikidata.A new node in the user's  Personal Knowledge Graph  is created that references the node in the  Google's   Knowledge Graph. Personal Entities When you reach the edge of your recorded knowledgeThe Wiki GambitCreate your own on the flyAutomatic contextualizationfor thoughts and discovered web resourcesFocus on what you write, not where you put itPersonal Entity: wiki: type of website that visitors can editIn case no public entity matches the user's search a new  Personal Entity  node is created in the user's Personal Knowledge Graph. This is analogous to the greatest gambit of the  wiki.  When you reach the edges of your knowledge just create a new page for it. Here it is more fine grained, it is just a node. You do not need to think up a name for a page. Nor would you need to worry about where it is created, because the identity of the node is independent from where you put it.  Context of discovery and Justification Like the eval and apply of LISPContext of justification: refers to the later or final phase of research when evidence is applied to and compared with a hypothesis.Context of discovery: StubThe Lakatos's term  Context of discovery  can be created by marking trails during your web research with HyperPost, whereas in the   Context of justification  linking to web resources discovered completes the circle. Blaze Trails Attach Narrative Trails to entity nodeslink to web resourcesThe context for a sentence automatically contextualizes linked resourceDiscussion Threads: It is possible to attach  Narrative Trails  to any entity node so that more information about it can be further elaborated. These narrative trails comprise sequences of paragraph, which in turn, consist of sentences for individual thoughts. In addition links to web resources can be attached so that they are linked to relevant contexts and will not be lost. Deep Re-arrangability and Re-purposing Reuse through transclusion any trails or contextproduce every sentence is a node, it can be moved, transcluded in any contextsocial media    Posts,  blog  posts,  Presentations, Project Plans, Issue Trackers rooted in your own graph of all your  articulated knowledgetransclusion: technical method of including some or all of one stored document in another document, without having to copy the data itselfDeep Rearrangeabilty: Ted Nelson: American information technologist, philosopher, and sociologist; coined the terms "hypertext" and "hypermedia"immitationg paper: social media: interaction among people in which they create, share, and/or exchane information and ideas in virtual communities and networksPosts: blog: discussion or informational site published on the World Wide WebPresentation slide: A slide is a single page of a presentation. Collectively, a group of slides may be known as a slide deckBy providing suitable structural links all kinds of presentation format's like  social media    Posts,  blog  posts,  Presentation slides,  etc can be applied to arbitrary network of nodes in the Thought Graph. Combine that with  transclusion  and we have "Deep Rearrangeabilty"  ref  required to solve  Ted Nelson's problem with "immitating paper"  ref   Capture Intertwingularity as scaffoldings of everything you care about in one placeAdd new capabilities at the Meta LevelHyperPost: The Thought Processor for Google+Google+: interest based social networking serviceSocial Knowledge Network: Intersection of Knowledge Graph, Google+ Circles and Thought GraphsGoogle+: interest based social networking serviceCircles: entire saffolding: Vannevar Bush: American electrical engineer and science administratorMemex: hypothetical proto-hypertext system that Vannevar Bush described in 1945HyperPost: The Thought Processor for Google+trails: Trail blazing: StubMemex: hypothetical proto-hypertext system that Vannevar Bush described in 1945Connected neighborhoods of nodes thus conveyed contain not only the information presented in the narrative trails, but they also contain as it were the entire scaffolding  with which they were erected.  Trail blazing  as in the  Memex  Demo This presentation was created in HyperPostPosts can be derived from it and will be publishedword processor: computer program used for writing and editing documentsHyperPost is used to generate the presentation it remains the master.Working with it preserves all the familiar characteristics of  a word processor augmented to accommodate thoughts and knowledge in their native associative graph model.  ConclusionHyperPost shows the way how to overcome the problem with paperIt is put forward as one possible way forward to reinvent hypertext for Academia Availibility Hyperpost landing page: Landing Page | hyperPostThis presentation will shortly be  available at  Hyperpost landing page  For people who sign up for the beta an extended version will be made available presenting a much larger graph, containing our development road map. It will be dynamically extended. Thanks And Thanks for all the fish

      map the expanding frontier

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  17. www.preprints.org www.preprints.org
    The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and Regeneration
    4
    1. Public_Reviews 13 May 2026

      eLife Assessment

      This Review Article nicely synthesizes the development, applications, and recent technical advances of the nitroreductase/prodrug system, highlighting how it enables precise spatiotemporal cell ablation and experimental platforms for studying regenerative mechanisms and screening for pro-regenerative or protective compounds. Together, the article provides a conceptual and practical overview that will help researchers adopt and further develop this versatile approach in regenerative biology. It will be of interest to researchers studying regeneration, disease modelling, and targeted cell ablation, particularly those working with zebrafish and other genetic model systems.

      Summary
    2. Public_Reviews 13 May 2026

      Reviewer #1 (Public review):

      Summary:

      Kim and Parsons present a timely overview of the NTR/prodrug system and its applications in regenerative biology research, with particular emphasis on tissue-specific cell ablation. The system has substantially advanced the field by enabling non-invasive, conditional cell elimination, and has proven especially powerful in zebrafish, though applications in other classical model organisms are also noted. The review covers the historical origins of the NTR system, its use in regeneration studies, small-molecule screening, and genetic and CRISPR-based screening, as well as future directions including the development of the highly efficient NTR2 enzyme variant.

      Strengths:

      This is a useful and well-structured contribution. The manuscript is a valuable resource for the regeneration biology community.

      Weaknesses:

      The revised manuscript shows significant improvements; however, two points remain insufficiently addressed and should be resolved in the final version.

      (1) The term 'suicide gene'

      As noted in my first round of revisions, the term 'suicide gene' as applied to bacterial nitroreductase remains unaddressed in the revised manuscript, despite being scientifically inappropriate and a potential source of confusion regarding the NTR/Mtz mechanism.

      'Suicide' implies an intrinsic, cell-autonomous programme of self-destruction. This is incompatible with the NTR/Mtz system, in which cell death is experimentally induced through exogenous administration of metronidazole (Mtz) by the investigator. While the 'suicide gene' framing may have utility in the cancer therapy literature, likely to aid communication with non-specialist and clinical audiences, however, it is not standard in the zebrafish field, where NTR is more accurately described as a conditional toxigene. Since this review focuses predominantly on zebrafish models, its terminology should reflect that of the relevant literature.

      A further conceptual problem with the 'suicide gene' framing is that it obscures the pharmacological nature of Metronidazole. Mtz is a pharmaceutical agent with intrinsic baseline toxicity: extended exposure or modestly elevated concentrations cause toxic side effects and lethality even in non-transgenic (wild-type) zebrafish (PMID: 24428354). NTR-expressing cells do not self-destruct; rather, they are rendered selectively hypersensitive to Mtz relative to other eukaryotic cells by virtue of expressing the enzyme. This distinction is mechanistically important and should be reflected in the language used throughout the manuscript.

      In summary, the term 'suicide gene' does not accurately capture enzyme-mediated bioactivation of an exogenous prodrug and should be removed from the manuscript.

      (2) Barriers to using the NTR/Mtz system in non-aquatic model organisms

      In response to my suggestion that the title should include "zebrafish" to accurately convey the scope of the review to prospective readers, the authors stated that "there is no intrinsic barrier to adopting this technique more broadly in other systems," citing the example that "NTR was first developed in mice, but with a prodrug that proved difficult to use, and it was not widely pursued." These two statements are, however, contradictory: if the prodrug proved difficult to use, this constitutes precisely the kind of practical barrier the authors claim does not exist. The authors should clarify and reconcile this inconsistency, and provide a more thorough discussion of why the NTR/Mtz system has seen limited adoption in classical model organisms, such as mice and Drosophila.

      Review 1
    3. Public_Reviews 13 May 2026

      Reviewer #2 (Public review):

      Summary:

      Kim and Parsons reviewed the nitroreductase (NTR)/prodrug system: when engineered cells expressing the enzyme NTR are treated with prodrug (e.g. metronidazole), NTR converts the prodrug into cytotoxic compound which kill these cells. The review covers how the system has been developed, spatiotemporal control of targeted cell ablation, and its broad utility to study regenerative mechanisms, model human diseases, and screen chemicals to discover pro-regenerative and protective compounds. They further discussed the newer version of NTR, more potent prodrug, and experimental design, which not only expand the possible utility of the NTR/prodrug system, but allow the research community to develop a precise, reproducible and versatile platform.

      Strengths:

      The review summarized landmark work application of the NTR/prodrug system, and recent studies in model organisms, with focus on the model organism zebrafish. The review provides a good gateway to understanding the system and considering regenerative studies.

      Weaknesses:

      None.

      Comments on revisions:

      The authors have addressed the previous points, and the manuscript has been greatly improved.

      Review 2
    4. Public_Reviews 13 May 2026

      Reviewer #3 (Public review):

      Summary:

      This manuscript by Kim and Parsons presents an overview of the nitroreductase/metronidazole (NTR/MTZ) cell ablation system.

      Strengths:

      This manuscript nicely places the NTR/MTZ system in context of other cell ablation methods, with a discussion of their respective advantages and disadvantages. This review is particularly useful for highlighting the many ways the NTR/MTZ system has been applied to study regeneration of multiple cell types and to model different degenerative human diseases. The review concludes with a discussion on recent improvements made to the system and practical considerations and "best practices" for NTR-based experiments. This review could be a helpful resource, especially for researchers new to regeneration or cell ablation studies.

      Comments on revised version:

      I thank the reviewers for revising the manuscript to expand their discussion of using the prodrug/NTR system in other model organisms while also revising the abstract to make it clear this review will be zebrafish focused. With these revisions, this review provides an informative overview of how the prodrug/NTR system has not only been an important tool for regeneration studies and but also for elevating the zebrafish as a regeneration model. That said, including other model organisms could have been a nice addition to the last section on experimental considerations, especially in the context of discussing potential barriers to wider adoption of the NTR system. However, given that the vast majority of studies using the NTR system are in zebrafish, the current scope of this review is understandable.

      Review 3
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    preprints.org/manuscript/202602.2055
  18. bafybeic4ydhnpvu45d7ubs6yzv3pkcakzgi5km5ll3xbhvjzsfcpud2cza.ipfs.dweb.link bafybeic4ydhnpvu45d7ubs6yzv3pkcakzgi5km5ll3xbhvjzsfcpud2cza.ipfs.dweb.link
    Untitled document
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  19. bafybeiboiiadc2jfnqkwmgffdxqicteosh7ihry2yqfa7arrletjgmvooi.ipfs.dweb.link bafybeiboiiadc2jfnqkwmgffdxqicteosh7ihry2yqfa7arrletjgmvooi.ipfs.dweb.link
    CastReader — Free Read Aloud for Kindle, PDF & Articles | Natural AI Voice - Chrome Web Store
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  20. bafybeiczepluofbtqwtlkcwcxoa7aidamvws7g7xds25cbtvxf6wk4hqiy.ipfs.dweb.link bafybeiczepluofbtqwtlkcwcxoa7aidamvws7g7xds25cbtvxf6wk4hqiy.ipfs.dweb.link
    CastReader — Free Read Aloud for Kindle, PDF & Articles | Natural AI Voice - Chrome Web Store
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  21. arxiv.org arxiv.org
    Trustworthy Blockchain-based Federated Learning for Electronic Health Records: Securing Participant Identity with Decentralized Identifiers and Verifiable Credentials
    1
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    arxiv.org/pdf/2602.02629
  22. themaskou.github.io themaskou.github.io
    Entropy, Eveness & Composition – Movement Ecology - Shorebirds
    3
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    themaskou.github.io/movement_ecology_shorebirds/qmd/chapter_1/ch1_10.html
  23. social-media-ethics-automation.github.io social-media-ethics-automation.github.io
    14.8. Bibliography
    1
    1. MinghaoYe1 13 May 2026

      The Know Your Meme source explains that copypasta is copied text spread repeatedly by people, not always by bots. I think this matters for moderation because harmful spam is not only automated. Human users can also flood platforms, annoy others, or spread harmful messages, so moderation tools need to consider behavior and context

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    social-media-ethics-automation.github.io/book/bsky/ch14_moderation/07_bibliography.html
  24. social-media-ethics-automation.github.io social-media-ethics-automation.github.io
    14. Content Moderation
    1
    1. MinghaoYe1 13 May 2026

      I think moderation is necessary, even on platforms that claim to support free speech. Without rules, spam, harassment, and offensive content can make people leave. But I also think moderation should be transparent, because users deserve to know why something is removed or hidden

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    social-media-ethics-automation.github.io/book/bsky/ch14_moderation/00_moderation.html
  25. www.biorxiv.org www.biorxiv.org
    High-resolution metagenome assembly for modern long reads with myloasm
    1
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    biorxiv.org/content/10.1101/2025.09.05.674543v1
  26. social-media-ethics-automation.github.io social-media-ethics-automation.github.io
    16.7. Bibliography
    1
    1. gvaldi 13 May 2026
      GoFundMe: #1 Fundraising Platform for Crowdfunding. URL: https://www.gofundme.com/ (visited on 2023-12-08).

      I think this is a really good example of positive crowdsourcing. I've donated on it a couple of times especially when it had to do with things I related to or believed. For example, when Immigration and deportations was terrible, I always tried to donate even a little bit in order to help reunite families.

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  27. litmir.club litmir.club
    Читать 'Поздняя осень в Венеции' - Рильке Райнер Мария - Страница 4 - ЛитМир Club
    1
    1. aenesid 13 May 2026
      Упою тебя колыбельнойнескончаемой, чтобы мнес жизнью твоей сопредельнойи спросонья быть, и во сне;быть бы в доме мне одному,поскольку ночь холодна,и вслушиваться в тебя, и во тьму,и в мир, и в лес допоздна.Часы зовут, продолжая бег;дно времени там, где мрак;а снизу ходит чужой человек,чужих разбудив собак;так в тишине мой длится мотив;с тебя не спускаю глаз;ими ловлю тебя, отпустив,ночью в который раз.
      райнер мария рильке стихи сон
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    litmir.club/br/
  28. sam.konubinix.eu sam.konubinix.eu
    simple pwa organiser
    2
    2. konubinix 13 May 2026
      drive the DOM from its own model while the CRDT also wants to

      This is not whzt happened. The issue was the sync of tne datastrores + the strong coupling between the rendering engine and its datastore

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    sam.konubinix.eu/braindump/posts/simple_pwa_organiser/
  29. social-media-ethics-automation.github.io social-media-ethics-automation.github.io
    16.6. Reflection Questions
    1
    1. gvaldi 13 May 2026
      In what ways do you think you’ve participated in any crowdsourcing online?

      I think I have participated in crowd sourcing when liking and engaging with TikTok's that go towards something important. A lot of times the video will include a caption saying, "Stay for 20 seconds so I can make enough money to pay for my dog's surgery". And although I don't know if I fully believe, a lot of other people will stay as well.

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    social-media-ethics-automation.github.io/book/bsky/ch16_crowdsourcing/06_reflections.html