10,000 Matching Annotations
  1. Jul 2025
  2. elifesciences.org elifesciences.org
    Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner
    1
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    elifesciences.org/articles/78517
  3. elifesciences.org elifesciences.org
    Structural mechanism of strand exchange by the RAD51 filament
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    elifesciences.org/reviewed-preprints/107114v1
  4. elifesciences.org elifesciences.org
    Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5
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    elifesciences.org/reviewed-preprints/107037v1
  5. elifesciences.org elifesciences.org
    Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers
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    elifesciences.org/reviewed-preprints/106979v1
  6. elifesciences.org elifesciences.org
    Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection
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    elifesciences.org/reviewed-preprints/106621v1
  7. elifesciences.org elifesciences.org
    Calibration and validation strategy for electromechanical cardiac digital twins
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    elifesciences.org/reviewed-preprints/106555v1
  8. elifesciences.org elifesciences.org
    CHROMAS: A Computational Pipeline to Track Chromatophores and Analyze their Dynamics
    9
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    elifesciences.org/reviewed-preprints/106509v1
  9. elifesciences.org elifesciences.org
    Coenzyme A governs proinflammatory macrophage metabolism
    2
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    elifesciences.org/reviewed-preprints/106473
  10. elifesciences.org elifesciences.org
    CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teeth
    9
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    elifesciences.org/articles/105153
  11. elifesciences.org elifesciences.org
    A temporally restricted function of the dopamine receptor Dop1R2 during memory formation
    12
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    elifesciences.org/articles/99368
  12. elifesciences.org elifesciences.org
    Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs
    1
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    elifesciences.org/reviewed-preprints/107534
  13. elifesciences.org elifesciences.org
    The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA
    6
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    elifesciences.org/articles/96414
  14. elifesciences.org elifesciences.org
    A geometric shape regularity effect in the human brain
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    elifesciences.org/reviewed-preprints/106464v1
  15. elifesciences.org elifesciences.org
    Making plant tissue accessible for cryo-electron tomography
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    elifesciences.org/reviewed-preprints/106455v1
  16. elifesciences.org elifesciences.org
    Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle
    1
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    elifesciences.org/reviewed-preprints/106303v1
  17. elifesciences.org elifesciences.org
    Multifaceted role of galanin in brain excitability
    3
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    elifesciences.org/articles/98634
  18. elifesciences.org elifesciences.org
    Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice
    13
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    elifesciences.org/articles/91609
  19. elifesciences.org elifesciences.org
    Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula
    10
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    elifesciences.org/articles/88588
  20. elifesciences.org elifesciences.org
    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
    42
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    elifesciences.org/articles/101984
  21. elifesciences.org elifesciences.org
    The yellow gene influences Drosophila male mating success through sex comb melanization
    11
    1. abrasiliano 07 Jul 2025
      These observations suggest that the pleiotropic effects of yellow on male mating success might result from effects of yellow in the adult CNS, particularly in fru-expressing neurons.

      This sentence really shows how complex and interconnected gene function can be. It's not just that the yellow gene affects pigmentation, it might also influence behavior through its role in specific brain cells.

    2. abrasiliano 07 Jul 2025
      It seemed worthwhile therefore to examine more closely one example of a gene mutation affecting behavior and to ask two questions, (1) how does it bring about its effect? [and], (2) what part might it play in evolution?”

      Even back in 1956, Bastock was asking questions that are still relevant today, not just about how a gene affects behavior, but also what that means in terms of evolution.

    3. abrasiliano 07 Jul 2025
      The study reveals the importance of scientists considering that genes that affect behavior may do so by changing anatomy rather than by altering the brain

      This is a reminder to scientists (and us) that behavior isn’t just about brain chemistry; sometimes it’s about how the body is built.

    4. Kevingomezgg 02 Jul 2025
      Yellow protein is expressed in sex combs (Hinaux et al., 2018, Figure 3G,H), where it is presumably required for synthesis of black dopamine melanin in the sex comb ‘teeth’.

      Melanization = adding dark pigment (melanin) to certain body parts. In this case, melanization makes the sex combs stronger and more rigid, helping males grab females. Without yellow, the sex combs are lighter and weaker.

    5. Kevingomezgg 02 Jul 2025
      t expression of yellow in fru-expressing cells is neither necessary nor sufficient for yellow’s effect on male mating success.

      Yellow doesn’t need to be in brain cells to affect mating; the problem is somewhere else.

    6. Kevingomezgg 02 Jul 2025
      The yellow males lack melanin pigments in their sex combs, which changes their structure.

      Key shift from neural to anatomical explanation, behavioral defect actually caused by structural changes in sex combs, not brain chemistry.

    7. dmays 02 Jul 2025
      However, we found that suppressing yellow expression in the larval CNS, dopaminergic neurons, or serotonergic neurons (Figure 2—figure supplement 3, FET, P values ranging from 0.45 to 1), or in all neurons (Figure 2E, FET, p=1 in all cases) or all glia (Figure 2F, FET, p=1), had no significant effect on male mating success.

      This result was surprising because it shows that turning off yellow in key parts of the nervous system—including neurons involved in mood and movement—does not affect male mating behavior. This suggests that yellow doesn’t act in the brain or nerves to influence mating, challenging the original hypothesis.

    8. dmays 02 Jul 2025
      We hypothesized that the MRS might contain an enhancer driving yellow expression and found that ChIP-seq data indicate the Doublesex (Dsx) transcription factor binds to this region in vivo (Clough et al., 2014).

      This shows that the yellow gene might be turned on by a DNA region called the MRS, which is controlled by the Doublesex (Dsx) protein. Since Dsx helps control male and female behaviors in flies, this suggests that Dsx might directly control yellow to help males mate successfully.

    9. Victoria23 02 Jul 2025
      (MRS)

      Stands for Male Reproductive System. It includes the testes (sperm is made), seminal vesicles (store sperm), accessory glands (affects female behavior after mating), ejaculatory duct and bulb (transfer sperm to female)

    10. Victoria23 02 Jul 2025
      insect pigment genes cause changes in the fly’s brain because these pigments are made from dopamine, a chemical messenger that acts in the brain.

      These are actions or signals that males use to attract a mate, and convince those mates to reproduce offspring with them.

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    elifesciences.org/articles/49388
  22. elifesciences.org elifesciences.org
    Ribozyme-catalysed RNA synthesis using triplet building blocks
    3
    1. Victoria23 07 Jul 2025
      RNA oligonucleotides

      This is short, synthetic strands of RNA, typically ranging from 2 to 50 nucleotides in length, used in various molecular biology applications

    2. Victoria23 07 Jul 2025
      template secondary structures.

      This is the folded conformations that a DNA or RNA template can adopt due to intramolecular base pairing, forming structures like hairpins or stem-loops, It can interrupt or intervene with DNA replication, transcription, translation and etc.

    3. Victoria23 07 Jul 2025
      no replicase ribozyme has been observed in existing life forms;

      Most likely because they have been replaced by more efficient protein enzymes due to evolution.

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    elifesciences.org/articles/35255
  23. elifesciences.org elifesciences.org
    Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16
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    elifesciences.org/reviewed-preprints/106265v1
  24. elifesciences.org elifesciences.org
    Evidence for systematic - yet task- and motor-contingent - rhythmicity of auditory perceptual judgements
    2
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    elifesciences.org/reviewed-preprints/105734v1
  25. elifesciences.org elifesciences.org
    Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
    3
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    elifesciences.org/reviewed-preprints/105396v2
  26. elifesciences.org elifesciences.org
    mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
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    elifesciences.org/reviewed-preprints/104979v2
  27. elifesciences.org elifesciences.org
    Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
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    elifesciences.org/articles/104237
  28. elifesciences.org elifesciences.org
    Birds migrate longitudinally in response to the resultant Asian monsoons of the Qinghai-Tibet Plateau uplift
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    elifesciences.org/reviewed-preprints/103971v2
  29. elifesciences.org elifesciences.org
    Exploiting functional regions in the viral RNA genome as druggable entities
    2
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    elifesciences.org/reviewed-preprints/103923v2
  30. elifesciences.org elifesciences.org
    Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments
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    elifesciences.org/reviewed-preprints/103797v2
  31. elifesciences.org elifesciences.org
    Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex
    3
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    elifesciences.org/reviewed-preprints/102923v2
  32. elifesciences.org elifesciences.org
    SIRT2 protects against Japanese encephalitis virus infection in mice
    4
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    elifesciences.org/reviewed-preprints/106778
  33. elifesciences.org elifesciences.org
    Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution
    6
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    elifesciences.org/articles/104508
  34. elifesciences.org elifesciences.org
    An increase in reactive oxygen species underlies neonatal cerebellum repair
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    elifesciences.org/reviewed-preprints/102515v2
  35. elifesciences.org elifesciences.org
    Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
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    elifesciences.org/reviewed-preprints/101918v2
  36. elifesciences.org elifesciences.org
    mirror determines the far posterior domain in butterfly wings
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    elifesciences.org/articles/96904
  37. elifesciences.org elifesciences.org
    The Natural History of Model Organisms: The secret lives of Drosophila flies
    3
    1. Victoria23 02 Jul 2025
      Environmental change is actually a complex of changes, both abiotic and biotic.

      Abiotic factors like temperature and humidity affect D. melanogaster's growth and survival, with optimal conditions boosting development and extremes causing harm. Biotic factors like helpful microbes support health, while predators, pathogens, and competition can reduce survival.

    2. Victoria23 02 Jul 2025
      Their decaying host resources are also home to many microbes, as well as to other arthropods

      Many of the microbes include yeast and bacteria, and for the arthropods they include other Drosophila flies, mites, beetles and ants. These microbes and arthropods benefit each other. For example the Saccharomyces cerevisiae (baker’s yeast) is often found on rotting fruit; provides nutrients and volatiles that attract flies. The arthropods, such as the mites, beetles and ants, can often be harmful to the Drosophila flies, as they do compete for food and nutrients and often prey on eggs or larvae.

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    elifesciences.org/articles/06793
  38. elifesciences.org elifesciences.org
    Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome
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    elifesciences.org/reviewed-preprints/101850v2
  39. elifesciences.org elifesciences.org
    Context-dependent modulations of subthalamo-cortical synchronization during rapid reversals of movement direction in Parkinson’s disease
    2
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    elifesciences.org/articles/101769
  40. elifesciences.org elifesciences.org
    A conserved code for anatomy: Neurons throughout the brain embed robust signatures of their anatomical location into spike trains
    2
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    elifesciences.org/reviewed-preprints/101506v2
  41. elifesciences.org elifesciences.org
    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
    3
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    elifesciences.org/articles/101369
  42. elifesciences.org elifesciences.org
    A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis
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    elifesciences.org/reviewed-preprints/101327v2
  43. elifesciences.org elifesciences.org
    Age-dependent predictors of effective reinforcement motor learning across childhood
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    elifesciences.org/reviewed-preprints/101036v2
  44. elifesciences.org elifesciences.org
    Reproducibility of in vivo electrophysiological measurements in mice
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    elifesciences.org/articles/100840
  45. Jun 2025
  46. elifesciences.org elifesciences.org
    Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cells
    3
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    elifesciences.org/reviewed-preprints/103771
  47. elifesciences.org elifesciences.org
    IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming
    2
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    elifesciences.org/articles/100406
  48. elifesciences.org elifesciences.org
    Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
    4
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    elifesciences.org/reviewed-preprints/100162v2
  49. elifesciences.org elifesciences.org
    Imaging of brain electric field networks with spatially resolved EEG
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    elifesciences.org/reviewed-preprints/100123v2
  50. elifesciences.org elifesciences.org
    Imaging of brain electric field networks with spatially resolved EEG
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    elifesciences.org/articles/100123
  51. elifesciences.org elifesciences.org
    Investigating working memory updating processes of the human subcortex using 7T MRI
    4
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    elifesciences.org/articles/97874
  52. elifesciences.org elifesciences.org
    Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka
    3
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    elifesciences.org/reviewed-preprints/97106
  53. elifesciences.org elifesciences.org
    mirror determines the far posterior domain in butterfly wings
    1
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    elifesciences.org/articles/96904
  54. elifesciences.org elifesciences.org
    Functionally-Coupled Ion Channels Begin Co-assembling at the Start of Their Synthesis
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    elifesciences.org/reviewed-preprints/106791