3. Favourable results were obtained mainly from patients affected by negative symptom schizophrenia.
It's not often you find effective treatments for negative symptoms. As a schizoid myself, this looks like a valuable tool. I'd be fascinated to see how LDN and ULDN perform.
sildenafil and vardenafil, caused a significant improvement in sleep quality and depression in this cohort of HD patients with ED.
These are the effects I was expecting to find. cGMP plays a role in SCN nighttime signalling, though I expect it has other mechanisms as well.
In severe OSA, the use of sildenafil 50mg at bedtime plays a detrimental role on respiratory parameters
This is probably due to nasal congestion.
Because improvements occurred among nonsmokers, the nicotine effect appears not to be merely a relief of withdrawal symptoms.
As expected. This study was placebo controlled, too.
Ritanserin was highly effective in reducing Pain Total Index and analgesic consumption in chronic headache, and its activity was similar to that observed during amitriptyline treatment. A significant improvement of HRSD and HRSA(Hamilton Rating Scale for Anxiety) scores was observed during both treatments.
This may mean ritanserin is superior. Amitriptyline is a dirtier drug affecting more than just serotonin receptors. Therefore, ritanserin likely has fewer side effects. However, I'm not currently aware of any studies demonstrating this.
Pleskac, T. J., Kyung, E., Chapman, G. B., & Urminsky, O. (2021, April 23). Single- or double-blind review? A field study of system preference, reliability, bias, and validity. https://doi.org/10.31234/osf.io/q2tkw
als auch Beitragende anonymisiert
Da viele Autoren Pre-Prints ihrer Texte oder Präsentationen zu ihren Texten inst Netz stellen, ist es für die Gutachter oft nicht so schwer den Autor zu erraten - besonders bei kleinen Fach-Gemeinschaften. Insofern kann man bei double blind nie sicher sein, ob es am Ende doch nur single-blind ist.
Isaacson, Walter. ‘Opinion | I Was Part of a Trial for Pfizer’s Covid-19 Vaccine. It’s a Miracle for Genetic Medicine.’ Washington Post. Accessed 6 March 2021. https://www.washingtonpost.com/opinions/i-took-the-pfizer-covid-19-vaccine-its-a-miracle-for-genetic-medicine/2020/11/09/77e652d0-22bf-11eb-952e-0c475972cfc0_story.html.
Zhu, F.-C., Guan, X.-H., Li, Y.-H., Huang, J.-Y., Jiang, T., Hou, L.-H., Li, J.-X., Yang, B.-F., Wang, L., Wang, W.-J., Wu, S.-P., Wang, Z., Wu, X.-H., Xu, J.-J., Zhang, Z., Jia, S.-Y., Wang, B.-S., Hu, Y., Liu, J.-J., … Chen, W. (2020). Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: A randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)31605-6
Ennis, E. G. (2020, April 16). A Novel Solution to Academic Publishing. https://doi.org/10.31234/osf.io/gqxmu
There are good preprints and bad preprints, just like there are with journal articles. Overall, do not be afraid to be scooped or plagiarized! Preprints also actually protect against scooping [21,22]. Preprints establish the priority of discovery as a formally published item. Therefore, a preprint acts as proof of provenance for research ideas, data, code, models, and results—all outputs and discoveries.
Salah satu alasan untuk tidak mengunggah preprint adalah takut idenya dicuri,
Ini adalah faktor budaya yang lain. Ketakutan yang tidak beralasan. Justru dengan mengunggah preprint, peneliti dapat mengklaim ide lebih awal.
Preprint ada yang bagus dan ada yang buruk, peninjauan akan ada di tangan pembaca. Ini adalah hambatan budaya berikutnya, ketika mayoritas pembaca ingin melimpahkan tanggungjawab untuk memverifikasi, memeriksa, dan menjamin kualitas suatu makalah kepada para peninjau.
Pengalihan tanggungjawab ini sulit dilakukan ketika dokumen PR sendiri tertutup, dan tidak lepas dari bias.
Selain itu, dosen akan menyalahi prinsip yang disebarluaskan kepada para mahasiswa, untuk membaca secara kritis.
CONCLUSION: This randomized double-blind, placebo-controlled clinical trial demonstrated that Amla could reduce frequencies of heartburn and regurgitation and improve heartburn and regurgitation severity in patients with NERD.
Is there anything it can't do? I have noted, however, that larger doses cause nausea for me. That is, 3 or more grams on an empty stomach. I just vomited after taking 7.5 grams before my meal, but I have not yet established the causal link. It is the largest amount I've ever taken at one time. I suspect that it may have contributed significantly, but that it was also one out of half a dozen factors.
No Bias, No Merit: The Case against Blind Submission
Fish, Stanley. 1988. “Guest Column: No Bias, No Merit: The Case against Blind Submission.” PMLA 103 (5): 739–48. http://www.jstor.org/stable/462513.
An interesting essay in the context I'm reading it (alongside Foucault's What is an author in preparation for a discussion of scientific authorship.
Among the interesting things about it are the way it encapsulates a distinction between the humanities and sciences in method (though Fish doesn't see it and it comes back to bite him in the Sokol affair). What Frye thinks is important because he is an author-function in Foucault's terms, I.e. a discourse initiator to whom we return for new insight.
Fish cites Peters and Ceci 1982 on peer review, and sides with those who argue that ethos should count in review of science as well.
Also interesting for an illustration of how much the field changed, from new criticism in the 1970s (when the first draft was written) until "now" i.e. 1989 when political criticism is the norm.