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  1. Sep 2020
    1. Eyre, D. W., Lumley, S. F., O’Donnell, D., Campbell, M., Sims, E., Lawson, E., Warren, F., James, T., Cox, S., Howarth, A., Doherty, G., Hatch, S. B., Kavanagh, J., Chau, K. K., Fowler, P. W., Swann, J., Volk, D., Yang-Turner, F., Stoesser, N., … Walker, T. M. (2020). Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study. ELife, 9, e60675. https://doi.org/10.7554/eLife.60675

    2. We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]).