1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD47 Promotes, While Exposure to Apoptotic Cells Destroys the Fusion Program of Differentiating Myoblasts
    9
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12897927/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alpha‐Actinin‐3 Deficiency Links Genetic Susceptibility to Renal Fibrosis: Evidence From Hemodialysis Patients and Murine Models
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12897921/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deletion detection in SARS-CoV-2 genomes from COVID-19 patients: elimination of false positives
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12900060/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Drosophila gene encoding JIG protein (CG14850) is critical for CrebA nuclear trafficking during development
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC10287909/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The RRM domains of PARP14 mediate replication fork degradation in BRCA2-deficient cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12891911/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A method to unravel complexity in human peripheral blood B-cell subsets through multiomic cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analyses
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12900538/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Major Histocompatibility Complex immunogenetic diversity differs substantially across sea turtle species and genomic regions
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12891914/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular assemblies and pharmacology of cerebellar GABAA receptors
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12890884/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial control of myosin regulatory light chain phosphorylation modulates cardiac thick filament mechanosensing
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12891028/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Probabilistic mapping and automated segmentation of human brainstem white matter bundles
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12890787/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Co-delivery of synaptogenic and angiogenic nanoparticles in MAP scaffolds enhances post-stroke synapse formation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12893876/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conserved lipid metabolic reprogramming confers hypoxic and aging resilience
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894929/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 via LINE1 regulatory elements
    9
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894760/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune checkpoint inhibition increases antigen-specific T cell response in head and neck cancer
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12891685/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide screens identify core regulators of cell surface prion protein expression
    5
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894898/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ansa cervicalis and superior cervical ganglion contribute to the fiber composition of the human hypoglossal nerve and its branches
    4
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894957/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894743/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis
    25
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894849/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Diploid hepatocytes resist acetaminophen-induced liver injury through suppressed JNK signaling
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894925/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The long noncoding RNA AC093895.1 promotes ovarian cancer formation and metastasis through a positive feedback network dependent on the transcription factor SOX4
    6
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894752/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Traumatic Brain Injury and Endocytosis: Reduced Rodent Hippocampal Endocytosis Proteins and Human Clathrin Light Chain Polymorphisms Are Associated with Impaired Neurological Outcomes After TBI
    6
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894144/
  23. link.springer.com link.springer.com
    FBXW7 Inhibited M2 Macrophage Polarization in Endometrial Cancer by Reducing CCL2 Secretion Through Ubiquitination of MYBL2 Subtitle: The Role of FBXW7 on M2 Macrophage Polarization in EC
    18
    Visit annotations in context

    Tags

    Annotators

    URL

    link.springer.com/article/10.1007/s10528-025-11309-7
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bacteriophages JEP7 and PBC2, which target foodborne pathogens, elicit cytokine responses in mammalian cells
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12894461/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12890982/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZNF711 promotes enzalutamide resistance through transcriptional and epigenetic modification of the androgen receptor signaling pathway
    7
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12891305/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Organelle Sorting and Proteomic Analysis to Identify Proteins Involved in the Uptake and Intracellular Trafficking of Nanoparticles
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12893302/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12893248/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD44‐Binding Peptide‐Functionalized Antibiofouling Polymer Surface for High‐Performance Separation of Human Mesenchymal Stromal Cells
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12895219/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Longitudinal Dynamics of Physical Function With Anxiety and Depression in Parkinson's Disease: A Cross‐Lagged Panel Analysis of the PPMI Dataset
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12895980/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Novel Microfluidic System for 3D Epidermis and Full‐Thickness Skin Growth for Nanoparticle Safety Assessment
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12892020/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of dopamine D1 receptors at the axon initial segment-like process of retinal AII amacrine cells modulates action potential firing
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12352536/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hilar mossy cell oxytocin receptor signaling regulates adult hippocampal neurogenesis and context discrimination in mice
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12896251/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancement of drug delivery through fibroblast activation protein–targeted near-infrared photoimmunotherapy
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12890525/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lineage-matched Oropouche virus mRNA-LNP vaccines confer complete, cross-protective immunity in mice
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12892959/
  36. nmoer.pressbooks.pub nmoer.pressbooks.pub
    Chapter 33: Synthesis for Research Writing
    2
    Visit annotations in context

    Annotators

    URL

    nmoer.pressbooks.pub/english1101/chapter/chapter-23-2-synthesis-writing-mytext-cnm/
  37. inst-fs-iad-prod.inscloudgate.net inst-fs-iad-prod.inscloudgate.net
    Writing Spaces 5
    10
    1. sgrover6 14 Feb 2026
      Taking the time to review your annotations will also teach you aboutyourself as a reader

      Looking back on your annotations and comparing them to others' annotations of the same section is definitely an important part of the annotation process. If you look back at your own annotations and how it compares to the annotations of others', you will be able to get a better grasp of that section, which will enable you to be a better annotator in the future.

    2. sgrover6 14 Feb 2026
      Images, including gifs, function in many social annotation platforms.Sometimes writers use these humorously to illustrate their reactions, es-pecially when I ask them to annotate our syllabus and assignment sheets.Reginald, one of my students, included a gif of a man throwing a cellphone against a wall to illustrate his response to a request to keep cellphone notifications off during class.

      I have never thought about how people may use annotations in this way to describe how a certain thing makes them feel. It is interesting to think about what can be accomplished with this technology, since it adds another way that you can express yourself during the annotation process.

    3. sgrover6 14 Feb 2026
      What experiences haveyou had with annotation? How might those experiences prepare you to read incommunity with others?

      I have little experience with annotation, since I have never really thought that it would help me, and none of my previous instructors have ordered me to do so. I think annotation definitely has some benefits to it, but it just does not resonate with me, and maybe that is because I do not view reading the same ways as others.

    4. LoganMilton 14 Feb 2026
      This knowledgecan help you learn about others’ perspectives

      This statement is effective because it highlights one of the key benefits of collaborative or social learning.

    5. LoganMilton 14 Feb 2026
      Through socialannotation, you can contribute to conversations about reading and writingto enrich learning in the course, much like when you participate in classdiscussions

      This statement is strong because it clearly connects social annotation to active participation. By comparing it to class discussions, it helps readers understand that annotation is not just marking up a text—it’s a form of engagement and conversation.

    6. LoganMilton 14 Feb 2026
      Social annotation makes visible the different ways people read to ac-complish their goals

      This statement is effective because it highlights the value of perspective. By saying social annotation “makes visible” different ways of reading, it suggests that reading is not a single, uniform process.

    7. LoganMilton 14 Feb 2026
      Before the inven-tion of the printing press, it was common to share a text and annotationsamong groups of readers even though the technology made reproducingthe text and annotations time consuming

      This statement is strong because it provides historical context that deepens the reader’s understanding of annotation. By referencing a time before the printing press, it shows that sharing texts and annotations is not just a modern academic strategy, but a long-standing practice.

    8. LoganMilton 14 Feb 2026
      You’ll learn about what social an-notation may offer as a tool for engaging with the communities in whichyou read

      This statement is effective because it builds anticipation and introduces a new idea in a forward-looking way. By saying “You’ll learn,” it signals that the reader is about to gain knowledge or insight, which creates engagement and curiosity.

    9. LoganMilton 14 Feb 2026
      You may have used digital annotation tools. But, if you’re likemany of my students, annotation might have been a reading strategy youpracticed alone

      This statement acknowledges different possibilities—digital annotation tools versus practicing alone—which makes the statement balanced and realistic.

    10. LoganMilton 14 Feb 2026
      In a composition course, successful reading may differdepending on a writer’s purpose.

      I like this annotation because it shows an understanding that reading is not one-size-fits-all, especially in a composition course. This also shows how what they read depends on what they are trying to accomplish as a writer.

    Visit annotations in context

    Annotators

    URL

    inst-fs-iad-prod.inscloudgate.net/files/71efe96a-0886-43ba-b48e-3716c16eafeb/Sprouse - Reading In Conversation.pdf
  38. example.com example.com
    Annotating the law | Hypothes.is
    1
    1. mrzeed 14 Feb 2026
      Harnessing

      Problem There are no citations for this eBook. I would love to see citations. Especially for SoTL (Science of Teaching and Learning) - and particularly because this is an eBook for Higher Education. Without citations, you are merely doing bad-theft - because you give no credit. Watch from 3:42

    Visit annotations in context

    Annotators

    URL

    example.com
  39. openstax.org openstax.org
    3.1 Global Trade in the United States - Introduction to Business | OpenStax
    12
    1. ADRIAN.GONZALES180 14 Feb 2026
      The reason is the principle of comparative advantage, which says that each country should specialize in the products that it can produce most readily and cheaply and trade those products for goods that foreign countries can produce most readily and cheaply. This specialization ensures greater product availability and lower prices.

      The explanation of comparative advantage helps clarify why countries trade even if one country can produce everything more efficiently. It reminds me of group projects because each person focuses on what they do best so the overall result is stronger. This challenges the argument that stopping trade would protect jobs, because trade actually increases efficiency and total output.

    2. ADRIAN.GONZALES180 14 Feb 2026
      U.S. managers must develop a global vision if they are to recognize and react to international business opportunities, as well as remain competitive at home. Often a U.S. firm’s toughest domestic competition comes from foreign companies. Moreover, a global vision enables a manager to understand that customer and distribution networks operate worldwide, blurring geographic and political barriers and making them increasingly irrelevant to business decisions. Over the past three decades, world trade has climbed from $200 billion a year to more than $1.4 trillion.1 U.S. companies play a major role in this growth in world trade, with 113 of the Fortune 500 companies making over 50 percent of their profits outside the United States.

      The main point of this section seems to be that having a global vision is no longer optional for U.S. businesses. I found it interesting that many U.S. companies like Apple and Microsoft earn over half their profits outside the United States. This shows that even companies we think of as “American” are actually deeply dependent on international markets.

    3. Kaleb_Chavez 14 Feb 2026
      Even if the United States had an absolute advantage in both coffee and air traffic control systems, it should still specialize and engage in trade. Why? The reason is the principle of comparative advantage, which says that each country should specialize in the products that it can produce most readily and cheaply and trade those products for goods that foreign countries can produce most readily and cheaply. This specialization ensures greater product availability and lower prices.

      Comparative advantage is a great way to increase productivity because even if one country has the absolute advantage in producing a lot of goods, it would be better if another country could produce those goods for a lower cost.

    4. Kaleb_Chavez 14 Feb 2026
      Many countries depend more on international commerce than the United States does. For example, France, Great Britain, and Germany all derive more than 55 percent of their gross domestic product (GDP) from world trade, compared to about 28 percent for the United States.5

      This shows how important doing business internationally is for the well-being of a country. Furthermore, it shows how beneficial trade is for creating jobs.

    5. Chris_Alcantar 14 Feb 2026
      outsourcing

      Outsourcing refers to sending domestic jobs that can be done in one country to another, typically to reduce costs. They can reduce costs by outsourcing to lower-income countries, where they pay less for the same amount of work they pay for in their own country. There are pros and cons, such as being able to provide lower-cost services or products, but this means that jobs are being removed from the country to a different country, which results in the unemployment percentage going up.

    6. Chris_Alcantar 14 Feb 2026
      protectionism

      Without protectionism, free trade exists. Itallows anyone, businesses included, to buy and sell without restrictions. It has been nearly impossible in today's world to have free trade, as each nation protects its home industries from outside competition through different forms. Most, if not all, countries have some form of protectionism. They do this so as not to cause harm to their economy and local industries.

    7. Igarcia824 14 Feb 2026
      Companies decide to “go global” for a number of reasons. Perhaps the most urgent reason is to earn additional profits. If a firm has a unique product or technological advantage not available to other international competitors, this advantage should result in major business successes abroad. In other situations, management may have exclusive market information about foreign customers, marketplaces, or market situations. In this case, although exclusivity can provide an initial motivation for going global, managers must realize that competitors will eventually catch up. Finally, saturated domestic markets, excess capacity, and potential for cost savings can also be motivators to expand into international markets. A company can enter global trade in several ways, as this section describes.

      This is important because it explains why companies choose to expand into other countries. Businesses often go global to make more profit, especially if they have a unique product or special knowledge that gives them an advantage. They may also expand because their home market is full, they have extra production capacity, or they can reduce costs by operating internationally. Understanding this helps us see how and why companies grow beyond their own borders.

    8. Igarcia824 14 Feb 2026
      A country has an absolute advantage when it can produce and sell a product at a lower cost than any other country or when it is the only country that can provide a product. The United States, for example, has an absolute advantage in reusable spacecraft and other high-tech items. Suppose that the United States has an absolute advantage in air traffic control systems for busy airports and that Brazil has an absolute advantage in coffee. The United States does not have the proper climate for growing coffee, and Brazil lacks the technology to develop air traffic control systems. Both countries would gain by exchanging air traffic control systems for coffee.

      These paragraphs explain the absolute advantage and why countries benefit from trade. This means that if each country is better at producing certain goods, they should specialize in what they do best and trade. By doing this, both countries would benefit instead of trying to produce things they are not good at making.

    9. aidan.coffman869 14 Feb 2026
      Even if the United States had an absolute advantage in both coffee and air traffic control systems, it should still specialize and engage in trade. Why? The reason is the principle of comparative advantage, which says that each country should specialize in the products that it can produce most readily and cheaply and trade those products for goods that foreign countries can produce most readily and cheaply. This specialization ensures greater product availability and lower prices.

      Comparative advantage is a simple way for countries to benefit from trade. Some countries have an absolute advantage in certain goods and can trade those goods to a different country that may need them, in exchange for a good that they need. This promotes efficiency in our economy because everyone will be better off trading for a good they need, rather than producing it themselves at a high price. Comparative advantage will also show what goods need to be imported and exported in a country.

    10. aidan.coffman869 14 Feb 2026
      Each year the United States exports more food, animal feed, and beverages than the year before. A third of U.S. farm acreage is devoted to crops for export. The United States is also a major exporter of engineering products and other high-tech goods, such as computers and telecommunications equipment. For more than 60,000 U.S. companies (the majority of them small), international trade offers exciting and profitable opportunities. Among the largest U.S. exporters are Apple, General Motors Corp., Ford Motor Co., Procter & Gamble, and Cisco Systems.

      Exporting and importing goods are some of the best ways for an economy to be efficient. Exporting, in particular, is beneficial for the U.S. because it creates new job opportunities and increases wages. Also, to export goods, the U.S. will be exposed to a competitive international market, which forces us to become more productive. Exporting goods internationally opens you up to a global market that offers higher production, greater profits, and greater scalability.

    11. ASHLEYHUNTER 13 Feb 2026
      One might argue that the best way to protect workers and the domestic economy is to stop trade with other nations. Then the whole circular flow of inputs and outputs would stay within our borders. But if we decided to do that, how would we get resources like cobalt and coffee beans? The United States simply can’t produce some things, and it can’t manufacture some products, such as steel and most clothing, at the low costs we’re used to. The fact is that nations—like people—are good at producing different things: you may be better at balancing a ledger than repairing a car. In that case you benefit by “exporting” your bookkeeping services and “importing” the car repairs you need from a good mechanic. Economists refer to specialization like this as advantage.

      This means that no country can efficiently produce everything it needs, so it makes sense to trade with others. Countries focus on producing goods and services they are best at making and trade for the things they cannot produce easily or cheaply. This specialization helps the economy grow because it lowers costs, increases efficiency, and allows everyone to benefit from trade.

    12. ASHLEYHUNTER 13 Feb 2026

      When a country’s currency depreciates, foreign goods become more expensive for domestic consumers, which tends to reduce imports. At the same time, the country’s goods become cheaper for foreign buyers, leading to an increase in exports. When a currency appreciates, the opposite occurs: imports become cheaper, exports become more expensive, and trade patterns shift as necessary.

    Visit annotations in context

    Annotators

    URL

    openstax.org/books/introduction-business/pages/3-2-why-nations-trade
  40. biz.libretexts.org biz.libretexts.org
    4.3: The Roles of Mission, Vision, and Values
    2
    Visit annotations in context

    Annotators

    URL

    biz.libretexts.org/Bookshelves/Management/Principles_of_Management/04:_Developing_Mission_Vision_and_Values/04.3:_The_Roles_of_Mission_Vision_and_Values
  41. www.biorxiv.org www.biorxiv.org
    Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    biorxiv.org/content/10.1101/2024.12.12.628112v1
  42. www.biorxiv.org www.biorxiv.org
    Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    biorxiv.org/content/10.1101/2025.11.07.687309v1
  43. www.biorxiv.org www.biorxiv.org
    Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    biorxiv.org/content/10.1101/2025.03.06.641957v1
  44. subslikescript.com subslikescript.com
    The Midnight Gospel: Season 1, Episode 8 script | Subs like Script
    3
    1. teryyyg 14 Feb 2026
      Can I feel inside my hand?It's a really... I've never...-Sense your hand.-I've never...I've never tried to do this.Okay. We're gonna try it right now.Okay, so sense your hand.Sense your index finger from the inside.Index. That's pinkie.Okay.-Yeah, it's kind of warm.-Yeah.Warm and what else?Numb. I don't know. Warm and numb.-Numb?-I don't know if numb is the right word.It just feels like an energy, you know.Yeah, you're right. See if you can senseyour whole hand from the insidein the same way.Take your time.If you've never done this before,it's hard.Yeah, I can feel something in there.Like...You do?Let it just...Gently let your attention go up your arm.Yeah.See if you can sense your whole armfrom the inside.Yeah, it feels like there's wolvesrunning in my arm.Oh. It does not.See if you can sense both of your armsat the same time from the inside.Yeah, I could do that.And if you can do that, add your legs,so that you can sense your armsand your legs at the same timefrom the inside.Yeah, it's weird. Yeah, I can do that.That...is presence.That's weird.-I've never done that before. It's weird.-That's presence.And what you're doingis you're not in your mind.This gets you out of your mind.You are not mediating your senseof your arms and legs through your mind.Through your mind. Mental.So that's a way to get out of your head.That's what you can do immediatelywhen you're on the side of the riverbeing nibbled by weasels and bees.And so the next thingyou can do, Duncan...Yes?...is, while you are sensingyour arms and your legs simultaneously...Yes....add two more facets.Look. Sense your arms and legs and look.-Look at what?-Whatever you see.Just let it come to you.-Don't search it out.-Okay.Just take in what you see.It's a bee with a thousand eyes and horns,-holding a dagger covered in pentagrams.-If you're on the side of the river,what else could it be?-You know...-Wait a minute. There's one more piece.Go ahead.And listen.So you sense your arms and legs...you look and you listen,all at the same time.Three things you're doing.Yeah, I get it. It gives youa kind of clarity. It kind of...It gives you clarityand it takes you into a slightly differentdimension of consciousness.It's quite different, actually.It is quite different.Because I've got a microphone in my face,it's hard for me to do what I would...Like if I was really sitting by myself...But I think that this recipefor a meditative exercise is awesome.Well, what it does is it allows youto get into presence without a teacherand without a penny to your name.-Yes.-And even as you are in that...um, state of presence...if you are in it, even for a minute,if you can stay in it for a minute,you will begin to sense the flow...-Right.-...of energy.You will sense that there is a river,because a lot of peopleon the side of the riverdon't even realize there's a river.Right.-So...-What's the river?It's reality, with its...flowing dynamism.
      meditation being present attention
    2. teryyyg 14 Feb 2026
      But also, you know,if you look at the world,what you seeis things appearing and disappearing,and humans are a partof the whole of that,and humans appear and they disappear.- Hmm.- Off the face of the Earth.That just happens.You know, our egos personalize itand we consider ourselves special cases.-Yes.-But we're really not, you know?We are a part of the wholeand everything in the wholetransforms all the time.It changes form. Transfigures.You're a special case.- That's 'cause I'm your mama.- No!No, I know there's... I know, but come on.There's no way to stop the heartbreak.How do you...What do you do about that?You cry.You cry.It's really hard.But it's definitely somethingeveryone's got to, you know, deal with.Yeah.And it's such a strange thing.I mean, the universe, it...it seems so stable......if you are...you know.......in this kind of automatic state.And the encounter with truth,which, for me, you dying...your dying....This thing has beenprobably the greatest...run-in with truth that I've hadin my whole life.You can't really...It's inexpressible.Yeah.But it's not like it makes you feel...This... This is not a feeling of, like...-This is not a desirable feeling.-No.But it's a feeling that every singlehuman being will experienceone way or the other.It is.But so much...So many of us are spending so much timeengaged in just ridiculous activities,it seems like,just to try to avoid this experience.Exactly.People really try to avoidthe consideration that they are gonna dieand that people they love are gonna die.It opens your heart.It breaks your heart open.- Yes.- You know?Our hearts have been closed,because we've closed them.We've defended ourselves against pain.And this opens them.Opening your heart sucks.- It hurts.- This is the thing.This is the thing Ram Dasstalks about all the... It hurts.Does it always hurt?Does opening your heart always just hurt?Are you just in a constant state of...No, it doesn't always hurt.But when it really cracks open, it hurts.You know? And it does.Even the hurt transforms,because if you inquire into the hurt,you know what you're experiencing is love.-Right.-The real deal.Yeah, it's... Yeah, right.Because it's seeing newness.It's seeing how much you value life.Yes. And the reasonI look better now than I ever have- is because I am more fully living.- Right.Because I'm living and dying consciously.Simultaneously, I'm holding both.
      • our egos personalize our life experience
      • transformation is what's constant in the universe
      • the only way to grieve is to cry
      • pain opens your heart
      • "if you inquire into the hurt, you know what you're experiencing is love"
      • living and dying consciously and simultaneously
      life death change transformation universe grief pain love
    3. teryyyg 14 Feb 2026
      You subscribe to the ideathat the formative years...create the beginning of a patternthat goes throughout your life?Yes. I would saythat the first five years of our livesshapes the personality structurein such a waythat any kind of spiritual workthat you're gonna do later......is going to involvelooking back at the patternsthat were set downin your family of origin.There's no way to avoid that?No. Because, think about it...I mean, anything that you werereinforced for in a positive way,you're gonna lock inas the way a person should be.So if people thought you, um...were especially wonderful if you broughtMommy the diaper for the new baby,then that's gonna tend to make youmore responsible.Maybe more responsiblethan you ever tended to be.Maybe super responsibleor maybe compulsively responsible.-Right.-So you start with where you are,but if you don't go backand see what's real and what's not real,then you're missing your way into reality,which is what spirituality is all about,as far as I'm concerned.It's distinguishing what's realfrom what's not real.And that's why a teacher is needed,and the teacher needs to bedevoted to truth.
      • the formative years build who you will be for the rest of your life
      • any healing work that you'll do later in life requires looking back at the formative years
      • a teacher needs to be devoted to truth
      truth the midnight gospel formative years healing self improvement childhood
    Visit annotations in context

    Tags

    Annotators

    URL

    subslikescript.com/series/The_Midnight_Gospel-11639414/season-1/episode-8-Mouse_of_Silver
  45. nmoer.pressbooks.pub nmoer.pressbooks.pub
    Chapter 43: Drafting Your Research Paper
    1
    1. JessicaMS 14 Feb 2026

      Catching your reader's attention in the first few seconds of reading is important and the sentence(s) after the introduction leads the pathway to the thesis.

    Visit annotations in context

    Annotators

    URL

    nmoer.pressbooks.pub/english1101/chapter/chapter-34-drafting-your-paper-mytext-cnm/
  46. www.youtube.com www.youtube.com
    La gestion de classe : une réalité et des pistes de solution
    1
    1. tanemika 14 Feb 2026

      La gestion de classe : Réalités et pistes de solution

      Ce document de synthèse récapitule les points essentiels de la formation dispensée par Elfa Hakimi et Ian Ducharme pour le Centre franco lors de l'Institut d'hiver 2025. Il explore les défis contemporains de la gestion de classe et propose des cadres théoriques et pratiques pour favoriser un environnement d'apprentissage optimal.

      Résumé exécutif

      La gestion de classe ne se limite pas à la discipline ; elle constitue un défi multidimensionnel exigeant une planification rigoureuse des ressources, l'établissement de relations authentiques et une communication pédagogique explicite. Les points saillants de cette analyse incluent :

      • L'approche systémique de Nancy Gaudreau : Utilisation de la métaphore des « cinq doigts de la main » pour structurer la gestion (ressources, attentes, relations, engagement, indiscipline).

      • Le passage de la réaction à la proaction : L'importance d'anticiper les comportements par l'enseignement explicite des routines et la connaissance approfondie du profil des élèves.

      • L'équilibre relationnel : L'adoption d'une posture d'adulte selon l'analyse transactionnelle pour éviter le « triangle dramatique » (Persécuteur, Sauveur, Victime).

      • L'engagement par la clarté : L'utilisation de résultats d'apprentissage (RA) et de critères de réussite (CR) visibles pour donner du sens aux tâches.

      --------------------------------------------------------------------------------

      1. Les défis de la gestion de classe contemporaine

      La gestion de classe est un défi incontournable qui influence directement le bon déroulement des apprentissages.

      Les comportements perturbateurs (bavardages, distractions, désobéissance, agressions) proviennent de facteurs divers :

      • Troubles intrinsèques : Troubles de l'attention ou difficultés émotionnelles.

      • Facteurs extrinsèques : Conflits interpersonnels ou situations familiales complexes.

      • Désintéressement : Concurrence des stimuli externes (ex. : jeux vidéo).

      La formation souligne que l'enseignant doit agir comme un animateur capable de « vendre sa salade » en rendant les tâches attrayantes et accessibles.

      --------------------------------------------------------------------------------

      2. Le cadre de référence : Les cinq ingrédients de Nancy Gaudreau

      Inspiré de l'ouvrage de Nancy Gaudreau, ce modèle utilise les doigts de la main pour symboliser les piliers d'une gestion efficace.

      A. Le Pouce : La gestion des ressources

      Il s'agit de l'organisation matérielle et humaine :

      • Temps et espace : L'espace est considéré comme le « troisième enseignant ». Il doit être polyvalent (travail en grand groupe, en dyades, centres de lecture).

      • Ressources humaines : Utilisation des élèves comme « gardiens du temps », implication des parents, des orthopédagogues et des techniciens.

      • Technologie : Intégration du codage et de la littératie numérique pour accroître la motivation.

      B. L'Index : Les attentes claires

      Ce pilier concerne la définition des règles et des routines :

      • Enseignement explicite : Ne rien prendre pour acquis. On modélise le comportement (« Je fais »), on le pratique ensemble (« Nous faisons »), puis l'élève l'exécute seul (« Tu fais »).

      • Signalétique visuelle : Utilisation de pictogrammes ou de systèmes de couleurs (vert, jaune, rouge) pour définir les niveaux de bruit permis selon l'activité (temps libre vs transition).

      C. Le Majeur : Les relations sociales positives

      La qualité du lien enseignant-élève est primordiale :

      • Authenticité : Apprendre les prénoms rapidement, s'intéresser aux centres d'intérêt des élèves (ex. : sport) et échanger de manière informelle.

      • Respect mutuel : Utiliser un ton calme, même en situation de conflit, et dissocier le comportement de la personne.

      D. L'Annulaire : L'attention et l'engagement

      Maintenir l'intérêt sur l'objet d'apprentissage :

      • Zone proximale de développement : Proposer des tâches ni trop simples ni trop complexes pour éviter le découragement.

      • Stratégies de captation : Utiliser des techniques de « reset » (éteindre les lumières, tapements de mains rythmés, signaux non verbaux comme le doigt sur le nez).

      E. L'Auriculaire : La gestion de l'indiscipline

      Bien que plus petit, ce doigt est crucial pour traiter les comportements inacceptables :

      • Proaction : Anticiper les crises en connaissant les dossiers scolaires (DSO).

      • Autorégulation : Enseigner l'empathie et la gestion des émotions par des cercles de communication.

      --------------------------------------------------------------------------------

      3. Cadres théoriques de l'accompagnement

      La théorie de la réalité (William Glasser)

      Ce processus en huit étapes vise à responsabiliser l'élève plutôt qu'à le punir :

      1. Créer un lien.

      2. Identifier le comportement.

      3. Faire évaluer le comportement par l'élève (« Est-ce que cela t'aide ? »).

      4. Établir un plan.

      5. Obtenir un engagement.

      6. Démontrer de la confiance.

      7. Ne pas accepter d'excuses ni punir inutilement.

      8. Persévérer.

      L'Analyse Transactionnelle (Eric Berne)

      Les interactions en classe sont influencées par trois états du « moi » :

      • Le Parent (Normatif ou Nourricier) : Établit les attentes ou soutient.

      • L'Adulte : État rationnel et équilibré à privilégier pour la résolution de problèmes.

      • L'Enfant (Spontané, Soumis ou Rebelle) : Siège des émotions.

      Le Triangle Dramatique à éviter :

      • Le Persécuteur : Domine et punit (« Tu es insupportable »).

      • Le Sauveur : Fait le travail à la place de l'élève, nuisant à son autonomie.

      • La Victime : Se sent impuissante et évite ses responsabilités (« Je suis nul »).

      --------------------------------------------------------------------------------

      4. Pistes pratiques et méthodologiques

      | Thème | Stratégies suggérées | | --- | --- | | Communication | Remplacer « Est-ce que tu comprends ? » par « Peux-tu reformuler dans tes mots ? ». | | Littératie | Utilisation de centres d'apprentissage et de la Littératie Structurée (80% grand groupe, 15% petit groupe, 5% individuel). | | Numératie | Pratiques pédagogiques à fort impact, manipulation de matériel concret, robotique et classes « collaboréflexives ». | | Rétroaction | privilégier le renforcement positif (« strokes ») et célébrer les progrès par des privilèges ou des certificats de valeur. |

      Conclusion

      Une gestion de classe efficace repose sur la capacité de l'enseignant à rester flexible et à adapter son style (autocratique, démocratique ou permissif) selon la situation.

      En rendant l'apprentissage visible et en structurant l'environnement de manière prévisible, l'enseignant réduit les opportunités d'indiscipline et favorise le succès de tous les élèves.

      gestion de classe webinaire conférence 2026 comportement discipline inclusion handicap
    Visit annotations in context

    Tags

    Annotators

    URL

    youtube.com/watch
  47. crmintler.com crmintler.com
    Dressed to Kill -PS.pdf
    2
    1. JaKhari.Burnett 14 Feb 2026
      Again the gangster was illuminating changes in the lives of his

      I was unable to complete the quotation, but gangsters are a mirror businessmen. As was discussed in American Values and Organized crime, gangsters operate on the belief that humans are inherently corrupt and they are above the "suckers" for embracing that. In the full quote, which expands onto the next page, it discusses their mirroring of their counterparts. Gangsters serve as a simultaneously less and more apparent indicator of the trends of these people at the time in their embracing of their base desires and subsequent frequenting of these institutions.

    2. JaKhari.Burnett 14 Feb 2026
      More than ever before, prod uct s wereimportant not only because of the immediate function they served,but because of the images they conveyed.

      This sentence immediately explains a theme that I think is relevant, especially to The Great Gatsby. Presentation. Gangsters seek to build an image of respectability despite their criminal behaviors, dressing lavishly and building fronts (though cleaning their money is a big component) Gatsby throws his parties and dresses in fine clothes to make an impression. Bill The Butcher dressed in finer clothes than his actual position would indicate.

    Visit annotations in context

    Annotators

    URL

    crmintler.com/americangangster/wp-content/uploads/2025/08/Dressed-to-Kill-Style-Consumption-and-the-Gangster.pdf
  48. www.juiceanalytics.com www.juiceanalytics.com
    20 Best Data Storytelling Examples (Updated for 2023) — Juice Analytics
    1
    1. divinadevin4794 14 Feb 2026
      The interactive website uses clever tactics to engage the reader — I particularly liked the quiz at the beginning. The combination of specific, personal examples and analytical research brings home the wide and discouraging discrepancies embedded in everything we read.

      I think that this works well thanks to the interactivity, allowing the user to be engaged with the content. This makes it so that the power of the message is strengthened by allowing users to fully see it all visually.

      DivinaDevin
    Visit annotations in context

    Tags

    Annotators

    URL

    juiceanalytics.com/writing/20-best-data-storytelling-examples
  49. nmoer.pressbooks.pub nmoer.pressbooks.pub
    Chapter 16: Literacy Narratives
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    nmoer.pressbooks.pub/english1101/chapter/chapter-12-personal-narratives-mytext-cnm/
  50. www.opensourceshakespeare.org www.opensourceshakespeare.org
    Romeo and Juliet, Act II :|: Open Source Shakespeare
    3
    Visit annotations in context

    Annotators

    URL

    opensourceshakespeare.org/views/plays/play_view.php
  51. www.usar.army.mil www.usar.army.mil
    Lt. Gen. Robert D. Harter
    1
    1. EBIKOMBOWEI 14 Feb 2026
      LTG Harter and his wife Erin have been married for over 35 years and have three children. They currently live in Stafford, Virginia.

      LTG Harter is divorced and has three children. His hometown is Alaska.

    Visit annotations in context

    Annotators

    URL

    usar.army.mil/Leadership/Article-View/Article/631391/lt-gen-robert-d-harter/
  52. www.wired.com www.wired.com
    Could AI-Generated Porn Help Protect Children?
    6
    1. tdupree03 14 Feb 2026
      risk.”

      Essentially, we aren't rehabilitating the offenders who engage in child pornography. We are simply providing them with another way to access the material, even if it is AI-generated. Treatment should be focused on correcting the sexual attraction towards children instead of assisting in facilitating their fantasies.

    2. tdupree03 14 Feb 2026
      First, there is no evidence that individuals without pedophilic proclivities will become interested in viewing child pornography merely because it becomes accessible in an AI-generated form

      In my opinion, more individuals will explore and play around with the idea of AI-generated child pornography once it gains more attention in the media.

    3. tdupree03 14 Feb 2026
      On top of that, the potential normalization of those viewings can be considered a harm to all children

      Even if the media people are viewing is AI-generated, we shouldn't normalize watching child pornography in any way. As mentioned in the article, watching AI pornography can be a gateway for individuals to act on their sexual desires.

    4. tdupree03 14 Feb 2026
      The Thorn report claims that within a year it will become significantly easier for AI to generate images that are essentially indistinguishable from real images

      I 100% agree with this statement because on various social media platforms, I have a hard time distinguishing which videos and images are AI-generated. Some of the images look cartoonish, while others look realistic. It's scary to think about how much AI will progress within the upcoming years.

    5. tdupree03 14 Feb 2026
      pedophilia is biological in nature, and that keeping pedophilic urges at bay can be incredibly difficult

      I don't agree with this statement. It seems as if they are justifying pedophilic tendencies. They are essentially saying that people can't resist their urges, so it's ok to do it.

    6. tdupree03 14 Feb 2026
      that AI-generated child sexual material could actually benefit society in the long run by providing a less harmful alternative to the already-massive market for images of child sexual abuse

      In my opinion, AI is one of the worst things created, especially during a technologically advanced generation. Many people abuse AI generators to cause more harm than good to society. This statement proves that individuals will find a way to justify the means of using AI.

    Visit annotations in context

    Annotators

    URL

    wired.com/story/artificial-intelligence-csam-pedophilia/
  53. www.planalto.gov.br www.planalto.gov.br
    D12686
    1
    Visit annotations in context

    Annotators

    URL

    planalto.gov.br/ccivil_03/_ato2023-2026/2025/decreto/D12686.htm
  54. www.archives.gov www.archives.gov
    Declaration of Independence: A Transcription
    6
    1. xXviolentvahlkampfiidaeXx 14 Feb 2026
      In every stage of these Oppressions We have Petitioned for Redress in the most humble terms: Our repeated Petitions have been answered only by repeated injury.

      The colonies have tried and tried again to communicate with Great Britain about their problems, and have repeatedly been left disappointed.

    2. xXviolentvahlkampfiidaeXx 14 Feb 2026
      , that mankind are more disposed to suffer, while evils are sufferable, than to right themselves by abolishing the forms to which they are accustomed.

      People are more likely to sit and suffer with what they are used to than to try and risk being more comfortable at the expense of giving up familiarity.

    3. xXviolentvahlkampfiidaeXx 14 Feb 2026
      overnments are instituted among Men, deriving their just powers from the consent of the governed, --That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government,

      According to Jefferson, governments receive their power through the people, and that if the government starts hurting its citizens then the citizens have the right to a revolution.

    5. xXviolentvahlkampfiidaeXx 14 Feb 2026
      a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation.

      Jefferson is declaring the separation of the colonies and Great Britain and explaining why.

    6. xXviolentvahlkampfiidaeXx 14 Feb 2026
      it becomes necessary for one people to dissolve the political bands which have connected them with another, and to assume among the powers of the earth,

      It is time for the connection between Great Britain and the colonies to be severed.

    Visit annotations in context

    Annotators

    URL

    archives.gov/founding-docs/declaration-transcript
  55. www.biorxiv.org www.biorxiv.org
    Outpacing E. coli: Development of Vibrio natriegens as a Next-Generation Cloning Host
    1
    1. daniel.caddell 14 Feb 2026
      Outpacing E. coli: Development of Vibrio natriegens as a Next-Generation Cloning Host

      I’m excited to see the development of a commercial V. natriegens for the community to try out. I had a few questions arise when reading your paper.

      First, in the introduction section you mention “This can be scaled from small culture tubes in the laboratory (to generate microgram quantities of DNA), to large-scale industrial bioreactors (to generate kilograms of DNA for vaccine production).” I am wondering where you envision the biggest benefit occurring? Would it be mostly for commercial DNA manufacturing? For general cloning in a research lab, I’m not sure how much I’ve ever worried about E.coli’s slower doubling time for my typical cloning workflow, since I often start cultures in the evening and let them grow overnight. With this system, I’m envisioning you would more likely to be starting cultures in the morning and harvesting in the afternoon. It would be nice to see a figure demonstrating what some hypothetical cloning workflows (with timelines) would look like to have a better understanding of how much time could be saved.

      Second, I am wondering if you tested transformation of any larger plasmids. Most plasmids you tested ranged from ~3kb to 6kb. However, some of the larger plasmids seem like they may have a growth penalty (Figure 6) and a decrease in transformation efficiency (Fig 9). Would these possible phenotypes be more pronounced if you are transforming a plasmid that is 20-25kb, which is about the max that E.coli can support?

    Visit annotations in context

    Annotators

    URL

    biorxiv.org/content/10.64898/2026.02.11.705132v1
  56. docs.ipfs.tech docs.ipfs.tech
    Address IPFS on the web | IPFS Docs
    1
    Visit annotations in context

    Annotators

    URL

    docs.ipfs.tech/how-to/address-ipfs-on-web/
  57. docs.ipfs.tech docs.ipfs.tech
    IPFS Gateway | IPFS Docs
    2
    Visit annotations in context

    Annotators

    URL

    docs.ipfs.tech/concepts/ipfs-gateway/
  58. bafybeib752droxo3kbeace4bftnhvu7zezhb4ptpxftppd3u2ykjdnjlzu.ipfs.dweb.link bafybeib752droxo3kbeace4bftnhvu7zezhb4ptpxftppd3u2ykjdnjlzu.ipfs.dweb.link
    bafybeib752droxo3kbeace4bftnhvu7zezhb4ptpxftppd3u2ykjdnjlzu.ipfs.dweb.link (1540×1006)
    1
    Visit annotations in context

    Annotators

    URL

    bafybeib752droxo3kbeace4bftnhvu7zezhb4ptpxftppd3u2ykjdnjlzu.ipfs.dweb.link/
  59. gemini.google.com gemini.google.com
    ‎Gemini - direct access to Google AI
    8
    1. noahjaysimon 13 Feb 2026
      updates.

      MDB is trying to become more HTAP like by introducing things like Analytics Nodes which have their own column store indexes and can run analytics on that.

    2. noahjaysimon 13 Feb 2026
      PostgreSQL's performance can drop by orders of magnitude (up to 1,000x in some benchmarks) compared to MongoDB because it cannot perform "in-place" updates.

      Yugabyte doesn't really have this issue since it doesn't have to re-write the whole document - it can just updated the specific field. For TigerData, the rowstore still has performance decrease but it is fast to read.

    4. noahjaysimon 13 Feb 2026
      While you can index JSONB fields, these indexes (like GIN, or Generalized Inverted Index) grow significantly faster than standard relational indexes.

      Indexes are important for OLTP databases since you have to perform a lot of joins and also even for point lookups you want to see a specific thing

    5. noahjaysimon 13 Feb 2026
      MongoDB's BSON, which allows the engine to skip directly to specific fields.

      MDB has a totally new format of BSON that has the "maps" to the data postgres doesn't have, and it's storage system isn't rigid so if you change a field it changes the whole block

    6. noahjaysimon 13 Feb 2026
      To read or filter even a tiny piece of data, the database must fetch and decompress the entire document from disk into memory.

      This isn't really an issue in Yugabyte, but kind of is in Tigerdata since it still uses this type of storage in its rowstore

    7. noahjaysimon 13 Feb 2026
      JSONB.

      PostgreSQL values data integrity (making sure your data is never corrupted) over the speed of tiny updates, and doesn't have deep internal mappings of data to jump to a specific field of the JSON file in the data like MDB does so it can't make a new version of writing that.

    8. noahjaysimon 13 Feb 2026
      When you update a single nested field, the database must rewrite the entire JSON object as a new row version (via MVCC, or Multi-Version Concurrency Control).

      In MDB you could update a single piece of the JSON object rather than rewrite the whole thing

    Visit annotations in context

    Annotators

    URL

    gemini.google.com/share/1df5c902381f
  60. sites.google.com sites.google.com
    B6 Hypothes.is Host (2324) - S2.W6 How the Build-Measure-Learn Cycle Really Works
    1
    1. morenoAlessandro1736 13 Feb 2026
      Design the experiment. First, you have to build out the details of the experiment and figure out how everything will fit and mesh together. For this, you must have a solid and reliable method of collecting data, meaning the data gathered must be reliable and actionable.

      This is an excellent cycle for experimentation. Its broad structure leaves room for flexibility, encouraging creativity and allowing everything in between to take shape naturally. It’s a simple yet highly effective way to move ideas forward and bring them to life.

      Morenoalessandro
    Visit annotations in context

    Tags

    Annotators

    URL

    sites.google.com/view/b6-hypohost/s2-w6-how-the-build-measure-learn-cycle-really-works
  61. www.youtube.com www.youtube.com
    Richard Feynman OBSERVED VON NEUMANN's BRAIN And Saw Something NOT HUMAN
    1
    Visit annotations in context

    Annotators

    URL

    youtube.com/watch
  62. wren.io wren.io
    Performance – Wren
    1
    1. mrcolbyrussell 13 Feb 2026
      Lua is more dynamic than Wren which makes its job harder. Lua also tries very hard to be compatible across a wide range of hardware and compilers. If you have a C89 compiler for it, odds are very good that you can run Lua on it. Wren cares about compatibility, but it requires C99 or C++98 and IEEE double precision floats. That may exclude some edge case hardware, but makes things like NaN tagging, computed gotos, and some other tricks possible.

      With these words, you might expect that programs that target the Wren reference implementation are faster than those written in Lua. But (again), languages are not language implementations, and the language implementation matters; while Wren programs written for the reference implementation available here are generally faster than programs that run on lua.org's Lua implementation, they're not faster than programs that run on LuaJIT.

      software performance
    Visit annotations in context

    Tags

    Annotators

    URL

    wren.io/performance.html
  63. www.americanyawp.com www.americanyawp.com
    Manuel Trujillo Accuses Asencio Povia and Antonio Yuba of Sodomy, 1731 | The American Yawp Reader
    1
    1. hISTORY_cLASS_Hasan 13 Feb 2026
      In 1731, Manuel Trujillo accused two Pueblo men, Acensio Povia and Antonio Yuba, of committing sodomy. Both Povia and Yuba denied this accusation, and Yuba invoked his status as a Christian in order to bolster his credibility. Governor Gervasio Cruzat y Góngora chose to exile Povia and Yuba to different pueblos for a period of four months, during which time they were to cease any and all communication with one another. This case explores sexual practices deemed “nefarious sins” as well as illustrates what scholars have called the colonial dilemma—the situation where Indigenous peoples remained in a subjected state despite theological equality following their Christian conversion

      The Faith and law aspect backing the rest of civilization was a moral inspiration to the culture to come, not an invitation for those already deemed savages (indigenous) for the unfair treatment they'd received being natives, as ultimately contradicting freedom implied by the ownership of the land and its governing. Laws against sexual promiscuity becoming the for front of laws is always related to the assimilation of nationals vs. dominants.

    Visit annotations in context

    Annotators

    URL

    americanyawp.com/reader/colliding-cultures/manuel-trujillo-accuses-asencio-povia-and-antonio-yuba-of-sodomy-1731/
  64. vpw-wiki.skirmishofwit.com vpw-wiki.skirmishofwit.com
    Bad Cats - VPW Knowledge Base
    1
    1. dcbenji 13 Feb 2026
      C4D glass material rendering reveals hidden artwork through transparent ramps (e.g., cat throwing dart under fishbowl ramp) -- VPX cannot render real-time refractions

      incorrect, newer versions of VPX 10.8+ can render refreactions and I believe the latest versions of bad cats use the refractions.

    Visit annotations in context

    Annotators

    URL

    vpw-wiki.skirmishofwit.com/tables/bad-cats/
  65. hyperallergic.com hyperallergic.com
    Archival Art Will Not Save Us
    1
    Visit annotations in context

    Annotators

    URL

    hyperallergic.com/archival-art-will-not-save-us/
  66. www.pewresearch.org www.pewresearch.org
    A Religious Portrait of African-Americans
    1
    1. alisonbarlow93 13 Feb 2026
      Outside of the historically black tradition, an additional 15% of African-Americans are members of evangelical denominations, such as the Southern Baptist Convention or Assemblies of God, and 4% are members of mainline denominations, such as the Disciples of Christ. Overall, the membership of historically black Protestant denominations is 92% black, while African-Americans make up relatively small portions of the membership of evangelical (6%) and mainline (2%) churches.

      I am a black person who is now an Episcopalian

    Visit annotations in context

    Annotators

    URL

    pewresearch.org/religion/2009/01/30/a-religious-portrait-of-african-americans/
  67. social-media-ethics-automation.github.io social-media-ethics-automation.github.io
    13.2. Unhealthy Activities on Social Media — Social Media, Ethics, and Automation
    1
    1. ejbech 13 Feb 2026
      Doomscrolling

      I think doomscrolling can be really damaging on mental health, but I also think that in the recent time it's become more than just bad news, it's when you're on a social media platform (and say to yourself: just 5 more minutes) and then end up scrolling for another hour or so, without being able to stop. This loss of self control can be really hard to grasp, and take a toll on ones mental health.

    Visit annotations in context

    Annotators

    URL

    social-media-ethics-automation.github.io/book_v0/ch13_mental_health/02_unhealthy_activities.html
  68. social-media-ethics-automation.github.io social-media-ethics-automation.github.io
    13.1. Social Media Influence on Mental Health — Social Media, Ethics, and Automation
    1
    1. ejbech 13 Feb 2026
      feeling calmer but isolated, re-downloading them, feeling worse but connected again

      This is such a central comment, because it's so true. I feel like we all a some point feel the need to take a step back, overwhelmed by the media, but also feeling the need to stay connected. So do we have to choose? feeling alone or feeling overwhelmed, it's hard to figure out how to work it out the best way.

    Visit annotations in context

    Annotators

    URL

    social-media-ethics-automation.github.io/book_v0/ch13_mental_health/01_effects_of_social_media.html
  69. www.newyorker.com www.newyorker.com
    Nova Scotia’s Billion-Dollar Lobster Wars
    1
    1. JaimeKerr 13 Feb 2026
      But James Nevin, the Sipekne’katik fisherman, still went out for elvers. “It’s fast money,” he said. On a philosophical level, he agreed with the elders: “You come in, you fuckin’ reap the benefits, and then, once it’s gone, that’s it. You feel pretty shitty.” But, with the money he made, he was able to buy a new boat for the lobster season.

      Interesting take -> Elver fishery here -> Nevin fishes illegally after DFO shut down the fishery (for EVERYONE mind you) -> says he feels like shit for stripping the land of resources, but he was able to buy a new boat for lobster season -> therefore IS quick fix

    Visit annotations in context

    Annotators

    URL

    newyorker.com/news/dispatch/nova-scotias-billion-dollar-lobster-wars