PatientID: 20

KindredID: 5

Case: M, 15Y0M, Spanish

DiseaseAssertion: VHL

FamilyInfo: The patient had first-degree familial antecedents.

CohortInfo: 36 pediatric patients with pheochromocytomas and/or parangangliomas.

CasePresentingHPOs: HP:0002666 (pheochromocytoma)

CaseHPOFreeText: The patient had a benign bilateral pheochromocytoma at age 15.

CaseNotHPOs: N/A

CaseNotHPOFreeText: The patient did not have any other tumours.

CasePreviousTesting: RET, SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, MAX

PreviouslyPublished: Yes source unknown.

SupplementalData: N/A

Variant: p.R167Q (c.500G>A)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVar: 2216 https://www.ncbi.nlm.nih.gov/clinvar/variation/2216/

CAID: N/A

gnomAD: 0.000003977 https://gnomad.broadinstitute.org/variant/3-10191507-G-A

VariantEvidence:N/A

MutationType: missense_variant;transition

CivicName: R167Q (c.500 G >A)

MultipleGeneVariants: N/A

PatientID: 12

KindredID: 2

Case: F, 25Y0M, Ethnicity Unknown

DiseaseAssertion: VHL

FamilyInfo: Patient has 2 siblings (patients 10 and 11) with the same mutation and pheochromocytoma.

CasePresentingHPOs: HP:0002666 (Pheochromocytoma)

CaseHPOFreeText: Unilateral pheochromocytoma (30mm)

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: SDHB (NM_003000.2), SDHC (NM_003001.3), SDHD (NM_003002.2), SDHAF2 (NM_017841.2), RET (exons 10–11 and 13–16, NM_020975.4), TMEM127 (NM_017849.3), MAX (NM_002382.3).

PreviouslyPublished: N/A

SupplementalData: Table 2

Variant: p.R167W (c.499C>T)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 2218, https://www.ncbi.nlm.nih.gov/clinvar/variation/2218/

CAID: N/A

gnomAD: 0.000007954, https://gnomad.broadinstitute.org/variant/3-10191506-C-T

VariantEvidence: Loss of heterozygosity could be detected in tumour DNA.

MutationType: missense_variant;transition

CivicName: R167W (c.499C>T)

MultipleGeneVariants: N/A

PatientID: N/A (sibling 1)

KindredID: 1

Case: Sex Unknown, 23Y0M, Ethnicity Unknown

DiseaseAssertion: pheochromocytoma

FamilyInfo: Her father had bilateral pheochromocytoma at the age of 13 and her grandfather had died of an unknown renal disease at the age of 50. They were both however not tested for any variants. There were no reports of hereditary cutaneous or uterine leiomyomas, renal cell cancer, neuroendocrine tumors or hemangioblastomas of the CNS/retina. Family evaluation revealed clinical and biochemical evidence of (bilateral) pheochromocytoma in two siblings 17 and age 19. These members also had the VHL mutation, while 2 unaffected family members were negative.

CasePresentingHPOs: HP:0002666 (pheochromocytoma)

CaseHPOFreeText: clinical and biochemical evidence showed bilateral pheochromocytoma

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: FH/RET/MAX/NF1/SDHB/SDHC/SDHD/TMEM127

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.G114G (c.342T>C)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: N/A

CAID: CA432421783 https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.342T%3EC

gnomAD: N/A

VariantEvidence: The FH variant is reported in 9/116704 alleles in the ExAC database. The VHL variant was no reported, however, an T>A transition at the same nucleotide position has been reported once in 1/121408 alleles (ExAC). Researchers suspect synonymous mutation has effects on transcript splicing (2 nucleotides into exon 2).

MutationType: synonymous_variant

CivicName: G114G (c.342T>C)

MultipleGeneVariants: N/A

PatientID: 28

KindredID: 28

Case: M, 34Y0M, Korean

DiseaseAssertion: Paraganglioma

FamilyInfo: No information provided.

CasePresentingHPOs: HP:0002668 (paraganglioma)

CaseHPOFreeText: The patient presented with paraganglioma (see table 3).

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, NF1, MAX, SDHA/SDHAF2/SDHB/SDHC/SDHD

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.P103L (c.308C>T))

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 1488386, https://www.ncbi.nlm.nih.gov/clinvar/variation/1488386/

CAID: N/A

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant; transition

CivicName: P103L (c.308C>T)

MultipleGeneVariants: N/A

PatientID: 5

KindredID: 5

Case: F, 11Y0M, Korean

DiseaseAssertion: Adrenal Pheochromocytoma

FamilyInfo: No information provided.

CasePresentingHPOs: HP:0006748 (adrenal pheochromocytoma)

CaseHPOFreeText: The patient presented with adrenal pheochromocytoma (see table 3)

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, NF1, MAX, SDHA/SDHAF2/SDHB/SDHC/SDHD

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.R161Q (c.482G>A)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 182983, https://www.ncbi.nlm.nih.gov/clinvar/variation/182983/

CAID: N/A

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant; transition

CivicName: R161Q (c.482G>A)

MultipleGeneVariants: N/A

PatientID: 7

KindredID: 7

Case: F, 40Y0M, Korean

DiseaseAssertion: Assumed VHL

FamilyInfo: No information provided.

CasePresentingHPOs: HP:0006748; HP:0005584; HP:0030405; HP:0006880 (adrenal pheochromocytoma, renal cell carcinoma, pancreatic endocrine tumor, cerebellar hemangioblastoma)

CaseHPOFreeText: The patient presented with adrenal pheochromocytoma. She also had other tumours, including renal cell carcinoma, pancreatic endocrine tumor, cerebellar hemangioblastoma (see table 3).

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, NF1, MAX, SDHA/SDHAF2/SDHB/SDHC/SDHD

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.R167W (c.499C>T)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 2218, https://www.ncbi.nlm.nih.gov/clinvar/variation/2218/

CAID: N/A

gnomAD: 0.000007954, http://gnomad.broadinstitute.org/variant/3-10191506-C-T

VariantEvidence: N/A

MutationType: missense_variant; transition

CivicName: R167W (c.499C>T)

MultipleGeneVariants: N/A

PatientID: 8

KindredID: 8

Case: F, 49Y0M, Korean

DiseaseAssertion: Assumed VHL

FamilyInfo: No information provided.

CasePresentingHPOs: HP:0006748; HP:0005584; HP:0006880 (adrenal pheochromocytoma, renal cell carcinoma, cerebellar hemangioblastoma)

CaseHPOFreeText: The patient presented with adrenal pheochromocytoma. She also had other tumours, including renal cell carcinoma and cerebellar hemangioblastoma (see table 3).

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, NF1, MAX, SDHA/SDHAF2/SDHB/SDHC/SDHD

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.W88R (c.262T>C)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 496053, https://www.ncbi.nlm.nih.gov/clinvar/variation/496053/

CAID: N/A

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant; transition

CivicName: W88R (c.262T>C)

MultipleGeneVariants: N/A

PatientID: N/A (sibling 2)

KindredID: 1

Case: Sex Unknown, 19Y0M, Ethnicity Unknown

DiseaseAssertion: pheochromocytoma

FamilyInfo: Her father had bilateral pheochromocytoma at the age of 13 and her grandfather had died of an unknown renal disease at the age of 50. They were both however not tested for any variants. There were no reports of hereditary cutaneous or uterine leiomyomas, renal cell cancer, neuroendocrine tumors or hemangioblastomas of the CNS/retina. Family evaluation revealed clinical and biochemical evidence of (bilateral) pheochromocytoma in two siblings 17 and age 23. These members also had the VHL mutation, while 2 unaffected family members were negative.

CasePresentingHPOs: HP:0002666 (pheochromocytoma)

CaseHPOFreeText: clinical and biochemical evidence showed bilateral pheochromocytoma

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: FH/RET/MAX/NF1/SDHB/SDHC/SDHD/TMEM127

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.G114G (c.342T>C)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: N/A

CAID: CA432421783 https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.342T%3EC

gnomAD: N/A

VariantEvidence: The FH variant is reported in 9/116704 alleles in the ExAC database. The VHL variant was no reported, however, an T>A transition at the same nucleotide position has been reported once in 1/121408 alleles (ExAC). Researchers suspect synonymous mutation has effects on transcript splicing (2 nucleotides into exon 2).

MutationType: synonymous_variant

CivicName: G114G (c.342T>C)

MultipleGeneVariants: N/A

PatientID: 1 (case)

KindredID: 1

Case: F, 17Y0M, Ethnicity Unknown

DiseaseAssertion: adrenal pheochromocytoma

FamilyInfo: Her father had bilateral pheochromocytoma at the age of 13 and her grandfather had died of an unknown renal disease at the age of 50. They were both however not tested for any variants. There were no reports of hereditary cutaneous or uterine leiomyomas, renal cell cancer, neuroendocrine tumors or hemangioblastomas of the CNS/retina. Further family evaluation revealed clinical and biochemical evidence of (bilateral) pheochromocytoma in two siblings 19 and age 23. These members also had the VHL mutation, while 2 unaffected family members were negative.

CasePresentingHPOs: HP:0006748 (adrenal pheochromocytoma)

CaseHPOFreeText: She had persistent episodes of high blood pressure, and was imaging led to the detection of bilateral pheochromocytoma, and underwent an adrenalectomy (which was complicated by cardiac decompensation in the context of catecholamine-induced cardiomyopathy).

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: FH/RET/MAX/NF1/SDHB/SDHC/SDHD/TMEM127

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.G114G (c.342T>C)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: N/A

CAID: CA432421783 https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.342T%3EC

gnomAD: N/A

VariantEvidence: The FH variant is reported in 9/116704 alleles in the ExAC database. The VHL variant was no reported, however, an T>A transition at the same nucleotide position has been reported once in 1/121408 alleles (ExAC). Researchers suspect synonymous mutation has effects on transcript splicing (2 nucleotides into exon 2).

MutationType: synonymous_variant

CivicName: G114G (c.342T>C)

MultipleGeneVariants: Germline, FH, c.556-4A>G

PatientID: 15

KindredID: 1

Case: F, 17Y0M, Spanish

DiseaseAssertion: VHL

FamilyInfo: None

CohortInfo: 36 pediatric patients with pheochromocytomas and/or parangangliomas.

CasePresentingHPOs: HP:0002666, HP:0002668 (pheochromocytoma, paraganglioma)

CaseHPOFreeText: The patient was admitted due to hypertension and secondary diabetes mellitus. She was found to have a norepinephrine secreting bilateral pheochromocytoma at age 15 and a thoracic-abdominal paraganglioma at age 17.

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, MAX

PreviouslyPublished: Yes source unknown.

SupplementalData: N/A

Variant: p.P95R (c.284C>G)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: N/A

CAID: CA351750809 http://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.284C%3EG

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant;transversion

CivicName: P95R (c.284C>G)

MultipleGeneVariants: N/A

PatientID: 5

KindredID: 5

Case: M, 11Y0M, Ethnicity Unknown

DiseaseAssertion: VHL

FamilyInfo: No details on family information.

CasePresentingHPOs: HP:0002666 (pheochromocytoma)

CaseHPOFreeText: Patient had clinical diagnosis of von Hippel Lindau syndrome and presented with pheochromocytoma.

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: SBHB, SDHC, SDHD, SDHAF2, VHL, EPAS1 (exons 9 and 12), RET (exons 10–11 and 13–16), TMEM127 and MAX

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.V170G (c.509T>G)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: N/A

CAID: CA351756196, https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_canonicalid?canonicalid=CA351756196

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant; transversion

CivicName: V170G (c.509T>G)

MultipleGeneVariants: N/A

PatientID: 11

KindredID: 2

Case: M, 21Y0M, Ethnicity Unknown

DiseaseAssertion: VHL

FamilyInfo: Patient has 2 siblings (patients 10 and 12) with the same mutation and pheochromocytoma.

CasePresentingHPOs: HP:0002666 (Pheochromocytoma)

CaseHPOFreeText: Bilateral pheochromocytoma (40mm and 30mm)

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: SDHB (NM_003000.2), SDHC (NM_003001.3), SDHD (NM_003002.2), SDHAF2 (NM_017841.2), RET (exons 10–11 and 13–16, NM_020975.4), TMEM127 (NM_017849.3), MAX (NM_002382.3).

PreviouslyPublished: N/A

SupplementalData: Table 2

Variant: p.R167W (c.499C>T)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 2218, https://www.ncbi.nlm.nih.gov/clinvar/variation/2218/

CAID: N/A

gnomAD: 0.000007954, https://gnomad.broadinstitute.org/variant/3-10191506-C-T

VariantEvidence: Loss of heterozygosity could be detected in tumour DNA.

MutationType: missense_variant;transition

CivicName: R167W (c.499C>T)

MultipleGeneVariants: N/A

PatientID: 10

KindredID: 2

Case: F, 25Y0M, Ethnicity Unknown

DiseaseAssertion: VHL

FamilyInfo: Patient has 2 siblings (patients 11 and 12) with the same mutation and pheochromocytoma.

CasePresentingHPOs: HP:0002666 (Pheochromocytoma)

CaseHPOFreeText: Bilateral pheochromocytomas (60mm and 40mm)

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: SDHB (NM_003000.2), SDHC (NM_003001.3), SDHD (NM_003002.2), SDHAF2 (NM_017841.2), RET (exons 10–11 and 13–16, NM_020975.4), TMEM127 (NM_017849.3), MAX (NM_002382.3).

PreviouslyPublished: N/A

SupplementalData: Table 2

Variant: p.R167W (c.499C>T)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 2218, https://www.ncbi.nlm.nih.gov/clinvar/variation/2218/

CAID: N/A

gnomAD: 0.000007954, https://gnomad.broadinstitute.org/variant/3-10191506-C-T

VariantEvidence: SNParray analysis of tumour DNA did not show LOH at any locus.

MutationType: missense_variant;transition

CivicName: R167W (c.499C>T)

MultipleGeneVariants: N/A

PatientID: 9

KindredID: 9

Case: M, 53Y0M, Korean

DiseaseAssertion: Adrenal pheochromocytoma

FamilyInfo: No information provided.

CasePresentingHPOs: HP:0006748 (adrenal pheochromocytoma)

CaseHPOFreeText: The patient presented with adrenal pheochromocytoma (see table 3).

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, NF1, MAX, SDHA/SDHAF2/SDHB/SDHC/SDHD

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.E70K (c.208G>A)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 43598, https://www.ncbi.nlm.nih.gov/clinvar/variation/43598/

CAID: N/A

gnomAD: 0.000004365, https://gnomad.broadinstitute.org/variant/3-10183739-G-A

VariantEvidence: N/A

MutationType: missense_variant; transition

CivicName: E70K (c.208G>A)

MultipleGeneVariants: N/A

PatientID: 8

KindredID: 4

Case: M, 13Y0M, Spanish

DiseaseAssertion: VHL

FamilyInfo: None

CohortInfo: 36 pediatric patients with pheochromocytomas and/or parangangliomas.

CasePresentingHPOs: HP:0002666, HP:0009711, HP:0006880 (pheochromocytoma, retinal capillary hemangioma, cerebellar hemangioblastoma)

CaseHPOFreeText: The patient had a benign pheochromocytoma that was secreting norepinephrine at age 13. The patient had a retinal angioma and cerebellar hemangioma at age 12.

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, MAX

PreviouslyPublished: Yes source unknown.

SupplementalData: N/A

Variant: p.R167Q (c.500G>A)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVar: 2216 https://www.ncbi.nlm.nih.gov/clinvar/variation/2216/

CAID: N/A

gnomAD: 0.000003977 https://gnomad.broadinstitute.org/variant/3-10191507-G-A

VariantEvidence:N/A

MutationType: missense_variant;transition

CivicName: R167Q (c.500 G >A)

MultipleGeneVariants: N/A

PatientID: 5

KindredID: 7

Case: M, 17Y0M, Spanish

DiseaseAssertion: VHL

FamilyInfo: No family history, assumed de-novo, but unclear if parents were tested to confirm de-novo assertion.

CohortInfo: 36 pediatric patients with pheochromocytomas and/or parangangliomas.

CasePresentingHPOs: HP:0002666 (pheochromocytoma)

CaseHPOFreeText: The patient had a benign bilateral pheochromocytoma that was secreting norepinephrine at age 10. At age 17, the pheochromocytoma reoccured but this time was malignant and metastasized to the lungs.

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET, SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, MAX

PreviouslyPublished: Yes source unknown.

SupplementalData: N/A

Variant: p.R167W (c.499C>T) *The authors of this paper have seemingly called the wrong protein change for this variant.

CaseProblemVariantFreeText: N/A

LegacyVariant: N/A

ClinVarID: 2218 https://www.ncbi.nlm.nih.gov/clinvar/variation/2218/

CAID: N/A

gnomAD: 0.000007954 https://gnomad.broadinstitute.org/variant/3-10191506-C-T

VariantEvidence: N/A

MutationType: missense_variant; transition

CivicName: R167W (c.499C>T)

MultipleGeneVariants: N/A

Singer Bonnie Tyler of 'Total Eclipse of the Heart' dies at 75<br /> by [[Mark Kennedy]] for AP News<br /> accessed on 2026-07-09T08:20:38

Max Welling 担任 CTO，这个选角意味深长。Welling 是图神经网络（GNN）和等变神经网络（如 SE(3)-Transformers）的核心推动者，而分子和晶体结构天然具有对称性和图结构。他的研究背景几乎是为分子属性预测量身定做的，比单纯的化学信息学出身的 CTO 更具 AI-native 的技术深度。

Max

It wouldn't be until almost a decade later that Delbruck, Golomb, et al. would be using math on the topic.

n.b. Delbrück was Jim Watson’s postdoc advisor at Caltech

see also:<br /> Golomb, Solomon W. Construction and Properties of Comma-Free Codes. With L. R. Welch and Max Delbrück, København, 1958. Biologiske Meddelelser Udg. Af Det Kongelige Danske Videnskabernes Selskab 23.

Golomb, S. W., et al. “Comma-Free Codes.” Canadian Journal of Mathematics, vol. 10, Jan. 1958, pp. 202–09. Cambridge University Press, https://doi.org/10.4153/CJM-1958-023-9.

Solomon Golomb (1932–2016)<br /> by [[Stephen Wolfram]] in blog: Stephen Wolfram Writings<br /> accessed on 2025-09-11T10:44:18

Book Review : Scientist Obscured by His Achievements - Los Angeles Times<br /> by [[Lee Dembart]] in Los Angeles Times 1988-10-04 <br /> accessed on 2025-09-11T10:29:10

proper balance between a person's life and their contributions to the world is a difficult matter

https://collections.archives.caltech.edu/repositories/2/archival_objects/19284

for - definition - worldview - Max Weber - overarching sensemaking system of meaning making

for - Max Weber - founding father - modern social science

for - book - The Protestant Ethic - Max Weber - adjacency - worldview - Max Weber - The Protestant Ethic

for - book - The Spirit of Capitalism - Max Weber - adjacency - worldview - Max Weber - The Spirit of Capitalism

Thank you for this great metaphor that matches well with an anti-capitalist reading of the film.

Die Europäische Union befindet sich bei der Umsetzung ihrer Klimaziele in einem entscheidenden Moment. In einem Bericht des European Council on Foreign Relations werden die politischen HIndernisse für die Dekaarbonisierung analysiert, Dabei wird detailliert auf die geopolitische Situation und auf die Bedingungen in den EU-Staaten eingegangen..

https://www.theguardian.com/environment/2023/sep/28/eu-faces-make-or-break-moment-for-green-transition-report-says

Report: https://ecfr.eu/publication/ends-of-the-earth-how-eu-climate-action-can-weather-the-coming-election-storm/

Russland hat durch Vetos dafür.gesorgt, dass die COP29 in dem autoritären Petrostaat Aserbaidschan stattfindet. Max Bearak berichtet in der New York Times auch über die steigenden Öl- und Gasexporte des Landes nach Europa.

https://www.nytimes.com/2024/11/11/climate/cop29-why-baku-azerbaijan.html

Die Methan-Emissionen steigen in den USA wie international weiter, im Widerspruch zu den Zusagen des Global Methane Pledge. Eine Hauptursache ist die weiter zunehmende Förderung von Öl und Gas. Neue Auswertungen des Instituts Kayrros ergeben detaillierter als bisher Cass die Emissionen in13 grossen Öl- und Gas-Fördergebieten mit zwei Ausnahmen gewachsen sind. Hintergrundbericht, auch über Maßnahmen der Biden-Administration und EU- zur Reduktion der Emissionen. https://www.nytimes.com/2024/09/19/climate/us-methane-greenhouse-gas.html

Kayrros-Artikel: https://www.energyintel.com/00000187-9953-d12b-a7bf-9dfb5fb60000

Nice website by Max

https://www.nytimes.com/2024/08/02/climate/azerbaijan-cop29-babayev.html

I am much reminded of people like Max Reisinger here, who show their vulnerability in their content, making it more real and authentic (note: Max did make a video outlining that YT became a persona of sorts, where he had to try to show vulnerability, which wasn't really what he was doing day to day).

Nick seems to/want to show more vulnerability, talk about more diverse topics (like Jungian psychology), making it, in my opinion, ultimately more mature and authentic content. I was becoming allergic to some creators, probably because they weren't doing this?

Dem Global Energy Monitor zufolge sollen in den kommenden Jahren 1,5 Billionen Dollar in LNG Terminals und Pipelines investiert werden. 20% dieser Summe sind für Europa geplant und hier wiederum ein großer Teil für Anlagen in Griechenland. Die USA lobbyieren in Mittel- und Südosteuropa intensiv, um ihr LNG dort zu verkaufen. Der subventionierte Aufbau von Gasinfrastruktur übersteigt den europäischen Bedarf bei weitem. Reportage in der New York Times zum Gasboom in Griechenland. https://www.nytimes.com/2024/05/31/climate/greece-europe-natural-gas-lng.html

Temperaturdaten aus der Messung von Baumringen zeigen, dass der Sommer 2023 in den nicht tropischen Gebieten der Nordhalbkugel eindeutig der heißeste Sommer seit mindestens 2000 Jahren war. Einer neuen Studie von forschenden um Jan esper zu Folge lagen die Temperaturen um 2 Grad über dem vorindustriellen Mittel, nicht nur, wie vom europäischen Wetterdienst Kopernikus publiziert, um 1,5 Grad https://www.derstandard.at/story/3000000219984/schnellster-co2-anstieg-in-der-luft-seit-50000-jahren

https://www.nytimes.com/2023/04/06/climate/oil-gas-drilling-investment-worldwide-willow.html

https://www.nytimes.com/2024/04/09/climate/greenhouse-gas-carbon-emissions.html

Max Reinhardt on Cabaret.

Cabaret as a form of satire, its literary, political, philosophical and poetic content are at the forefront of documentary interest; the ongoing collection and scientific utilization of its diverse manifestations is the central task of the German Cabaret Archive

The playful, satirical form of cabaret and its literary, philosophical, and poetic qualities are the focus of our documentary interest. The central task of the German Cabaret Archives is the continuous collection and the availability of these materials to academics and historians

A fascinating thesis about American historical perspective and our identity.

Does this play out with respect to Max Weber's thesis?

https://en.wikipedia.org/wiki/Max_Verstappen

Die New York Times analysiert den Auftritt von Sultan al-Jaber, Ölminister der Emirate und Präsident der COP28, beim „Peterberger Klimadialog“.Er unterscheidet zwischen Fossilen Brennstoffen und fossilen Emissionen. Viele Beobachter:innen interpretieren seine Statements optimistisch – sie sind aber deutlich auf eine Legitimation der Fossilindustrie ausgerichtet. https://www.nytimes.com/2023/05/03/climate/un-climate-oil-uae-al-jaber.html

Extension time

• inspiration
  • the author's mathematical formalism is inspired by reflexive monism work of Max Velman
  • https://hyp.is/go?url=http%3A%2F%2Fdocdrop.org%2Fvideo%2FCm9x_X3HEmI%2F&group=world

https://en.wikipedia.org/wiki/Karl_Lamprecht

Aby Warburg: Metamorphosis and Memory. Documentary, Biography, 2016. https://www.kanopy.com/en/lapl/video/5913764.

Written, Directed and Produced by Judith Wechsler<br /> Wechsler2016

Center for the Study of the Great Ideas

https://en.wikipedia.org/wiki/Verstehen

Max Raisin indicated that Gotthard Deutsch read several events with dates out of a little notebook during lectures. Was this really a notebook or possibly a small stack/deck of index cards? The could certainly be easily mistaken....

Check these references

https://www.youtube.com/watch?v=OSE281i5gNM

Joe Louis vs Max Schmeling (2nd meeting), June 22, 1938

it's a tricky thing with Max you can spend weeks and refining a patch and afterwards you're the idea is so much gone for yourself that now you have the perfect tool but you're not interested in using it anymore

Classic!

Walter Goldschmidt had a 1951 paper about coastal Californian foragers next to aristocratic slave keeping fishermen. These hunter-gatherers apparently had a work ethic similar to that of Max Weber's Protestant work ethic.

Did these fishermen have totem poles (aka decorated wood

Goldschmidt was a student of Alfred Kroeber. Would he have known or worked with Milman Parry?

Kroeber received his PhD under Franz Boas at Columbia University in 1901, the first doctorate in anthropology awarded by Columbia.

“Max Weber,100 años después” escrito por @damianpachon1 publicado en la revista @RevistaSemana, un artículo en donde se enmarca la transcendencia de la obra de Max Weber. Aunado a lo anterior me surge como interrogante ¿Cuáles son los tipos ideales mencionados en el texto con referencia a Inmanuel Kant? Me ha parecido muy interesante el artículo por lo que le pido me comparta cuáles son sus fuentes de consulta al realizar sus trabajos de investigación.

El artículo “Max Weber, 100 años después” es un texto introductorio sobre la vida, teoría y obras de Max Weber, a grandes rasgos. Me resultó útil, ya que explica de manera resumida el contexto histórico en que se encontraba este clásico.

Me gustaría preguntarle al autor ¿Por qué decidió escribir sobre Max Weber? y ¿A qué público esperaba llegar con este artículo?

This makes me wonder what the relation of this mode of "limited" thinking (represented by Ramism) has with Max Weber's ideas of Protestant work ethic? If we're not being creative like we may have been in the past, does it help us to focus on the mundane drudgery of our work at hand?

Transformar isso em observação sobre o significado físico do fluxo?

Note que esse fluxo implica numa escolha particular para o campo variacional. Seria interessante justificar essa escolha.

Em outras palavras, a prpriedade de quase propriamente mergulhada é preservada ao longo do fluxo.

This seems a bit neurotic, but perhaps I'm missing something.

These are interesting numbers to contemplate in terms of how few people have actually heard these ideas and arguments before in a serious way.

This adds more to my prior comment with the addition to Max Weber here. Cross reference some of my reading this past week on his influence on the prosperity gospel.

This philosophy also overlaps some of the resurgence of white nationalism and structural racism in the early 1900's which also tended to disadvantage people of color. ie, we can blame the coloreds because it's not structural inequality, but the failure of the individual (and the race.)

I love this book. I've reviewed it here.

Use min-max scaling for image processing & neural networks.

Evolução da carga

$$ \begin{aligned} Q(t) & \equiv Q_{\nabla\phi}(\Sigma) := {1 \over 4\pi} \int_{\Sigma} \langle \nabla\phi, \nu \rangle d\sigma_g \\ %% & = {1 \over 4\pi} \int_{\Sigma} d\phi \cdot \nu d\sigma = {1 \over 4\pi} \int_{\Sigma} \frac{\partial\phi}{\partial\nu} d\sigma \end{aligned} $$

$$ \begin{aligned} \Longrightarrow \frac{dQ}{dt} = {1 \over 4\pi} \int_{\Sigma} \left[ d(\partial_t \phi) \cdot \nu + d\phi \cdot \partial_t \nu + d\phi \cdot \nu \frac{tr_{\Sigma} \partial_t g}{2} \right] d\sigma \end{aligned} $$

Tomando \( \alpha = 2 \), obtemos: $$ \begin{aligned}

• {tr_{\Sigma} \partialt g \over 2} & = R - Rc(\nu, \nu) - \alpha \left( |\nabla \phi|^2 - (\partial{\nu} \phi)^2 \right) \ & = R - Rc(\nu, \nu) - 2 \left( |\nabla \phi|^2 - (\partial_{\nu} \phi)^2 \right) \end{aligned} $$

Note que,

$$\alpha = 2 \Longrightarrow S = R - 2 |\nabla \phi|^2,$$

que é justamente a função que precisamos estimar (veja prova do corolário 5.2), no caso particular de um campo gradiente.

Haja visto que no na aproximação eletrostática do eletromagnetismo clássico, o campo elétrico (em domínios simplesmente conexos) é gerado por um potencial escalar, isso sugere que, pelo menos nessa aproximação particular, podemos utilizar esse fluxo \((RH)_{\alpha}\), tomando o pontical elétrico como dado inicial para o fluxo do calor para mapas harmônicos.

Essa ideia é inspirada nas ideias das seções 2 e 3, desse artigo do Benhard List, onde ele observa que soluções estáticas desse fluxo, com \(\alpha\) escolhido adequadamente, coincide com as soluções estáticas para a equação de Einstein no vácuo.

For those of us who’ve had to deal with distinctions between audio and control signals, this is actually pretty major. However, it’s already become something in modular synthesis. People who get started in Eurorack, for instance, may not need to worry nearly as much about different types of signals as those who used Csound or, more importantly for this marketing copy, Cycling ’74 Max.

http://www.nytimes.com/1988/08/30/obituaries/dr-max-black-79-author-and-philosopher.html

https://www.scientificamerican.com/article/cognitive-ability-and-vulnerability-to-fake-news/

Dr. Maxwell John Dunbar, mentioned later in the text as the author of Environment and Common Sense which was published in 1971, began his “lifelong involvement with the Arctic” in August 1935 during an expedition to map the western Greenland coast (Grainger 1995, 306). Dunbar was born in Edinburgh, Scotland, attended the Merchiston Preparatory School followed by the Dalhousie Castle School, and finally, Fettes College. In 1933, Dunbar began attending the Trinity College in Oxford, England to study zoology where he met ecologist Charles Elton. After meeting Elton, Dunbar was introduced to the Oxford University Exploration Club. Through this club, Dunbar was invited to join the expedition in Greenland. He received a B.A. in 1937 and subsequently attended Yale University in New Haven, Connecticut on a Henry Fellowship (for more information on the Henry Fellowship see Yale University’s webpage https://yale.communityforce.com/Funds/FundDetails.aspx?4438534B376C50326C63483341496C39582F4435696B6F6554694364593150486764566B344156473663736768494B34585863553574432B646D5868384E6275). While studying at Yale University, Dunbar was able to take a trip to explore the glaciers of Alaska. He returned to Oxford, England, when Elton offered him the opportunity to join the 1939 eastern Canadian Arctic patrol. After accepting Elton’s offer, Dunbar enrolled at McGill University in Montreal, Canada as a graduate student. During his time at McGill University, Dunbar experienced the Canadian arctic for the first time by joining the R.M.S Nascopie. Dunbar began serving as the consular representative of the Canadian consulate in Greenland in 1942, and again in 1946. After leaving Greenland, Dunbar was employed by McGill University in the Department of Zoology. After beginning research for the Fisheries Research Board of Canada, he designed the first Canadian arctic research vessel Calanus. In 1947, Dunbar founded the Eastern Arctic Investigations laboratory at McGill University. His active involvement with McGill University continued until he retired and was appointed Professor Emeritus in 1982. He continued his quest for knowledge after “retiring” and published at least 32 articles after 1982 (Grainger 1995, 306-307).

References

Grainger, E. H. "Maxwell John Dunbar (1914-1995)." Arctic 48, no. 3 (1995): 306-07. http://www.jstor.org/stable/40511670.

Weber understands by power: the chance of a man, or a number of men "to realize their own will in communal action, even against the resistance of others."

Weber – Class, Status, and Power