1. Last 7 days
    1. The sampling framework employed a multistage stratified random sampling procedure to ensure comprehensive rep-resentation across educational contexts. Initial stratification criteria included grade level (junior and senior secondary),school type (public and private institutions), and geographic location (urban and suburban areas), with probability pro-portional to size sampling within each stratum.

      Another option for a follow-up article could be to delve into these categories; it would be interesting to see what differences, if any, exist regarding AI application in secondary education contexts.

    2. The conceptualization and empirical measurement of innovation ability has emerged as a critical domain within educa-tional research, particularly regarding technological integration.

      I think that this, as one of the three points of interest identified in this study, is a key point. It is important for students to be able to use and adapt technology in any field. While AI may have negatives, I would argue it is more important to find effective ways to integrate it into the classroom instead of just hoping students will not use it.

    3. Contemporary research has particularly emphasized distance learning applications, as evidenced by Mijwil et al.‘s[27] mixed-methods investigation of AI-enhanced remote education.

      I presume the implication is that in instances where students cannot engage in a face-to-face classroom experience, AI may be able to help with learning and answer questions on-demand. However, I definitely think this presents an equal number of challenges as it does opportunities--as AI is known to have "hallucinations" and cite nonexistent sources or present false information, how would students be able to verify what they read? Will students using AI in these contexts undermine research skills? How can these challenges be combated?

    4. The findings hold particular relevance in the current educational context where generative AI technologies are rapidlytransforming pedagogical practices and learning modalities, offering a timely contribution to both the scholarly discourseand educational practice.

      While I agree that this article is timely, I wonder how research into this topic will evolve over time since it is still relatively new. I think this leaves room for follow up once more data can be collected and the long-term implications can be more clearly determined.

    5. Within thiscontext, generative AI—defined as AI systems capable of producing, manipulating,and analyzing content across multiple modalities—represents a fundamental par-adigm shift in educational technology [6]. This shift manifests in the transformationof how students interact with information, construct knowledge, and develop criticalcompetencies, necessitating systematic examination of educational innovations [7].

      I think this sentence is a key point and introduces why this is a relevant and necessary topic of study for education.

    6. As generative artificial intelligence (AI) rapidly transforms educational landscapes,understanding its impact on students’ core competencies has become increasinglycritical for educators and policymakers.

      I think AI has definitely become an important consideration in the classroom regardless of subject area. As with the introduction of more affordable handheld calculators into schools, I think teachers will have to make room for AI so that students can learn to use it appropriately and effectively as a tool, as opposed to a substitute, for learning.

    7. enhancing critical thinking,creative problem-solving, and adaptive learning processes

      I am curious as to how the authors of this study measured this--a major concern regarding AI usage is that it might prove detrimental to critical thinking skills, in particular.

    Annotators

    1. Subsequently, they helped other women tomigrate.

      I'm so interested in this idea of chain migration and what avenues people use to do it. Like is it because there are existing pathways like physically,m or just rumour brings people to the same place.

    Annotators

    1. Standardization of intervention

      I understand these are features of the two visual aid formats, but I wonder how the color coding or, most importantly, the interactive element of the skeleton concept maps might've affected the findings. Might be useful to discuss this (if not mentioned in the limitations)

    2. A week later, after wash-out

      Might be useful to include a few lines justifying the wash-out period for this study specifically. What unique factors about podcasts or the included visual aids that might necessitate wash-out?

    3. studentparticipants for the pilot study were drawn from a cohort not enrolled in the main study armbut matched in training level and learning environment.

      Would help to mention it earlier as well

    4. 3.11.1 Steps for development of instrument (Clinical scenario-based SBA-type MCQs)

      Nicely done and written!

      My question would be: Any reliability testing done? Especially since the study has multiple iterations- how might the presence of test-retest reliability affect your interpretation of the findings?

    5. he purpose was to ensure thatall students began the case with a comparable baseline understanding of key conditions, therebyreducing variability in prior knowledge and increasing the reliability of post-interventionperformance measures

      Good call

    6. small sample of participants representative of the targetpopulation

      Where did the sample come from? is it from the rest of the batch (those who were not included?) or a different university?

    7. he sessionon ‘Red eye’ and ‘sudden painless loss of vision’

      Curious how these are usually taught in the curriculum

      +If known, what sort of need assessment was originally done to include those topics in the curriculum?

    8. was employed

      This is mentioned in later sections, but might be helpful to state clearly if it was designed by the researcher from scratch or adapted/modified from any other source

    9. 1.3 Rationale

      Adding a bit more about why the author thinks the intervention would affect CT specifically would greatly strengthen the rational

      ++

      I'm curious, any data on the effect of audio-only podcasts (without visual aids) on critical skills?

      The introduction mentions that the podcasts' potential in developing critical thinking is unexplored more than once- and a comparison between supplementing podcasts with either assumes effectiveness. Would love to see data tackling that point or at least a discussion of it

    10. A simple random sampling technique was applied to select participants for the study

      If the accessible population is 110 and the minimum target sample is 94, why did the author choose random sampling over purposive whole-population sampling?

    11. Figure 5

      Very informative graph.

      -Recommend editing the position of "immediate" and "Delayed" tests as it currently appears to associate with Groups A and B

      -The graph implies there's more cross over after Round two. Recommend editing it to clarify.

      -Might also be used to add your washout period to the graph

      -Kindly also connect Pre-test, control variable, and post-test by arrows; and unify the way "Audio podcast - clinical case discussion" is written in rounds 1 and 2

    12. Exclusion criteria

      Exclusion criteria are typically factors that may disqualify participants who are otherwise included in the study. With that in mind, what criteria might exclude any of your 4th year students from this study?

    13. Notably, their study revealed that 87% of surveyed students demonstrated a visuallearning preference, suggesting that audio-only formats may inadequately serve a largeproportion of learners. The authors proposed incorporating visual aids, such as images orinfographics in show notes to better support knowledge retention and accommodate diverselearning styles (Okonski et al., 2022)

      Might strengthen the rational section if added there

    1. Apple 2024 MacBook Pro Laptop mit M4 Max Chip mit 14-Core CPU und 32-Core GPU: 14,2" Liquid Retina XDR Display, 36 GB gemeinsamer Arbeitsspeicher, 1 TB SSD Speicher; Space Schwarz Besuche den Apple-Store 4,7 4,7 von 5 Sternen (409) var dpAcrHasRegisteredArcLinkClickAction; P.when('A', 'ready').execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( 'acrLink-click-metrics', 'click', { "allowLinkDefault": true }, function (event) { if (window.ue) { ue.count("acrLinkClickCount", (ue.count("acrLinkClickCount") || 0) + 1); } } ); } }); P.when('A', 'cf').execute(function(A) { A.declarative('acrStarsLink-click-metrics', 'click', { "allowLinkDefault" : true }, function(event){ if(window.ue) { ue.count("acrStarsLinkWithPopoverClickCount", (ue.count("acrStarsLinkWithPopoverClickCount") || 0) + 1); } }); }); | Spezifische Informationen suchen (function(f) {var _np=(window.P._namespace(""));if(_np.guardFatal){_np.guardFatal(f)(_np);}else{f(_np);}}(function(P) { P.when('A', 'dp-latency-marker').execute(function(A){ A.declarative('scroll-to-widget', 'click', function(event){ var $ = A.$; var target = $("#nile-inline-btf_feature_div"); if (!!target && target.length > 0) { target[0].scrollIntoView({behaviour:"smooth", block:"center"}); } }); }); })); .mvt-ac-badge-rectangle { border-radius:4px !important; display: inline-flex; color: #FFF; white-space: nowrap; padding: 2px 4px !important; background-color: #161D26 !important; border-color: #161D26 !important; } .mvt-ac-for-text { white-space: nowrap; overflow: hidden; text-overflow: ellipsis; color:#111; } .mvt-ac-badge-wrapper { margin:5px 0 10px; display: flex; flex-wrap: nowrap; align-items: center; } a:hover .mvt-ac-keyword-link { text-decoration:underline } .mvt-ac-badge-wrapper a.badge-link:hover { text-decoration:none; } .mvt-desc-space-rtl { margin-right:8px; } .mvt-desc-space { margin-left:8px; } Amazons Tipp empfiehlt hoch bewertete Produkte mit einem guten Preis-Leistungs-Verhältnis, die sofort versendet werden können. Amazons Tipp {"acAsin":"B0DLHZVKYB"} .delight-pricing-badge { background-color: #B12704 !important; margin: auto; font-family: "Amazon Ember", Arial, sans-serif; padding-left: 10px; padding-right: 10px; font-size: 12px !important; line-height: 24px !important; max-width: 140px; } .delight-pricing-badge-label { position: relative; z-index: 1; float: left; } .delight-pricing-badge-label-text { color: #ffffff !important; } .delight-pricing-container span { display: inline-block; vertical-align: middle; } .delight-pricing-container { padding-bottom: 5px; } .delight-pricing-badge-description-text { padding-left: 10px; margin: auto; font-family: "Amazon Ember", Arial, sans-serif; color: #111; } .reinventDelightPricing { color:#CC0C39 !important; } .delightPricingBadge { background-color: #CC0C39!important; padding:4px 8px 4px 8px; border-radius: 4px; display: inline-block; vertical-align: middle; margin-bottom: 4px; } .savingPriceOverride { color:#CC0C39!important; font-weight: 300!important; } .savingPriceOverrideEdlp { color:#565959!important; font-weight: 300!important; } 3.365,00 € mit 14 Prozent Einsparungen -14 % 3.365,00€ UVP: 3.899,00 € UVP: 3.899,00€3.899,00€ Die UVP ist der vorgeschlagene oder empfohlene Verkaufspreis eines Produkts, wie er vom Hersteller angegeben und vom Hersteller, einem Lieferanten oder Händler zur Verfügung gestellt wird.Weitere Informationen P.when('A', 'a-popover').execute('a-popover-count', function (A) { A.declarative('a-popover', 'mouseenter', function() { ue.count("tooltip.popover.opened", 1); }); }); KOSTENFREIE Retouren Diesen Artikel kostenfrei zurücksenden Für die von dir gewählte Lieferadresse sind kostenlose Rücksendungen verfügbar. Du kannst den Artikel aus einem beliebigen Grund in neuem und unbenutztem Zustand zurücksenden: keine Versandkosten. Weitere Informationen zu kostenfreien Retouren. Wie kann ich den Artikel zurücksenden? Gehe zu deinen Bestellungen und starte die Rücksendung Wähle die Rücksendemethode Versenden! Preisangaben inkl. USt. Abhängig von der Lieferadresse kann die USt. an der Kasse variieren. Weitere Informationen.

      amazon

    1. gennady.bereschnoy3:35 PM@Honza Zidek 🐖 Hallo Jan, One more Question: -we have, ( for ex.! ) Meta-Infor about :::--- "minLength": 32, "maxLength": 64, "pattern": { "regex": "^[a-zA-Z0-9-]{32,64}$", :::----------------- where the values like 32, 64, rexexp is NOT 100% specified or we still not able to found confirmation what is RIGHT values. So the Q is: !! Q!! what you prefer in such case?: some real-like value like it is on example, the null-value, till we get 100% confirmation about such specification ?Honza Zidek 🐖3:42 PMThe placeholder value is always good, and it is just an example, so put it whatever you know at the moment - like a real API key copied from the web of a providerThe pattern influences the validation, so if you are not sure with the regex, do not return any pattern at all (or pattern = null, which is the same for our parser)The same for maxLength and minLength BearbeitetHonza Zidek 🐖Sorry, I meant placeholder and not exampleLeandro R. Effinger3:46 PMgreat, thanks for the answer

      LEO WTF!?

    1. heir work without acknowledging it will be penalized.

      is there a best way to call this out? with tools like Grammarly or should this be completely removed ?

    2. My late policy and willingness to make accommodations are generous even during normal times, and if your life is being turned upside down, I’m willing to be as flexible as you need me to be—so long as you are active in communicating with me.

      This is a great policy. Thank you for the flexibility.

    1. Грипп — это острое вирусное заболевание, вызванное вирусами гриппа, которые относятся к семейству орнитоцировирусов. Оно отличается от простуды (респираторного вирусного инфекции) более тяжёлыми симптомами и риском осложнений. Вот основные моменты: Основные симптомы: Высокая температура (до 39–40 °C).Боль в голове и мышцах.Сухой кашель и насморк.Слабость, утомляемость.Часто головная боль и гнойные выделения из носа. Как передаётся: Через воздух: при кашле, чихании или дыхании.Контактным путём: через поверхности, на которых вирус остался в течение нескольких часов. Причины и патогенез: Вирус проникает в организм через дыхательные пути, размножается в клетках дыхательной системы и вызывает воспаление, что приводит к симптомам. Осложнения: Пневмония, вирусные инфекции, дыхательная недостаточность.Особенно опасен для детей, пожилых людей, людей с хроническими заболеваниями (например, диабетом, сердечными патологиями). Вакцинация:

      тут проверяем чего пишет мой ИИ

    1. activities, but James also relied on more objective measures, including the use of various recording devices, and examinations of concrete products of mental activities and of anatomy and physiology (Gordon,

      This is an example of the development of the empirical method, where scientist start to use more objective such as the usages of examinations or recording devices. Instead of using opinion-based methods to examine mental activities, like Wundt's idea of introspection, James use functionalism to properly focus on how mental activities helped an organism fit into its environment using test and experiments.

    2. and he believed that the goal of psychology was to identify components of consciousness and how those components combined to result in our conscious experience. Wundt used introspection (he called it “internal perception”), a process by which someone examines their own conscious experience as objectively as possible, making the human mind like any other aspect of nature that a scientist observed. He believed in the notion of voluntarism—that

      Wundt's view of psychology as a study of conscious experience was the start of psychology and I find it really interesting how this one though created the formal beginning of psychology. Wundt's usage of introspection (a process by which someone examines their own conscious experience as objectively as possible) is an early and significant way for Wundt to study the human mind. However, these experiences can be totally subjective from the actual person. How can one's experience be verified by another? I thought that introspection was an unreliable way to study psychology. In addition, Wundt's belief in volunteerism (the concept in which people have free will) will slowly become a more popular idea now. Especially in the present time, many people feel as if they can choose their own path and make their own decisions, rather than their lives being prechosen for them.

    1. So, in the East German "revision" of Cinderella, the fairy godmother has been eliminated

      Learning that the fairy god mother wasn't in the story was shocking. She was such a crucial part of the American story. I've never heard of a version where she gets her glam from a tree that started from her mother's grave, and grew from Cinderella's tears. - Olivia Fink German 2254.02

    1. Typically, a hemolytic attack starts with malaise, weakness, and abdominal or lumbar pain. Within a time frame of several hours to 2–3 days, the patient develops jaundice and often dark urine. T

      sxs

    2. G6PD is a housekeeping enzyme critical in the redox metabolism of all aerobic cells (Fig. 105-1). In red cells, its role is even more critical because it is the only source of NADPH, which directly and via GSH defends these cells against oxidative stress

      highlighted

    1. According to Joseph and Frances Gies, authors of Life in a Medieval Castle, Winter was the season from Michaelmas (September 29) to Christmas when wheat and rye were sown.  From the end of the Christmas holidays to Easter was the season when spring crops were sown: oats, peas, beans, barley, and vetches.  From the end of Easter week to Lammas (August 1) was summer, and from Lammas to Michaelmas was harvest, or autumn. (p. 206) This is in contrast to our modern calendar of seasons, which occur approximately as follows: Spring: March 20 Summer: June 21 Autumn: September 22 Winter: December 21

      Crying shaking throwing up

    1. The ability to feel connected to ones haukāinga and ahikā from adistance is a difficult compromise and one that many of our whānauhave to face if they choose to live away from their tūrangawaewae orlive overseas

      In the text even though Sciascia writes that "Many Māori of the diaspora are actively seeking and using virtual media to make and maintain strong connections with their haukāinga" I also believe it is difficult to maintain a genuine connection through social media without "kanohi ki te kanohi", the difficulty is that you do not get to interact on a personal level. It just allows you to feel more connected with human contact.

  2. learn-us-east-1-prod-fleet01-beaker-xythos.content.blackboardcdn.com learn-us-east-1-prod-fleet01-beaker-xythos.content.blackboardcdn.com
    1. Capitalism has been immensely successful, on many criteria. It ushered in theindustrial era, and the prosperity (for some people, but not everyone) that camewith it. It ruthlessly undermines old-fashioned restrictions and taboos, and probesendlessly to find new ways of generating private profit (some of which are sociallyuseful, some of which are not). It harnesses immense energy, creativity, anddiscipline from many of its participants

      What really caught my attention here is how Stanford points out that capitalism is both powerful and deeply flawed. It’s impressive that it’s been able to drive innovation and productivity, but also kind of scary how uneven the benefits are. If capitalism depends so much on people’s energy and creativity, what happens when more and more people feel burnt out or left behind by the very system they’re fueling?

    2. Most people think economics is a technical, confusing, and even mysterioussubject. It’s a field best left to the experts: namely, the economists.

      This is such a powerful statement because regular people are always taught that the economy is so confusing but in reality it is really not that hard but economists want to be known for having all the answers.

    3. Remember, a 10 percent improvement in productivityis just as good for employers as a 10 percent reduction in compensation.

      This really helped clarify how businesses think in terms of “unit labor cost.” I’d never thought of it like an equation before. But it also raises a disturbing point: workers are always being pushed to either work harder or accept less money. What would it take to flip this logic—so that gains in productivity automatically meant gains for the workers, not just the company?

    4. Some receive noincome at all: like the growing army of “interns” who now work for free, in hopes ofeventually landing a paying job.

      This made me think about how normalized unpaid internships have become, especially for young people trying to enter competitive fields. Is this "hope" of a future job enough to justify free labor? What happens when that hope doesn't ever lead to a job? It feels like a way to bypass labor laws under the premise of gaining experience

    1. Description

      The dual aspects of the Kundalini energy in Hindu mythology. Kali is the chaotic and raw force of awakening. With Durga as the refined and powerful manifestation of that energy once it is harnessed. Learn the transformative journey from the tumultuous awakening of Kundalini to its beneficial and enlightened expression.

    1. With the rise of the inclusion of Aboriginal artists in institutionalarts programming in the past twenty years, there has been in-creased dialogue around the nature and political/cultural impera-tive of Aboriginal arts presentation and discourse.

      With the inclusion of Aboriginal artists I also think that these creations have led to discussions about respectful, authentic representation to promote understanding, sovereignty, and reconciliation. I think it is important for the aboriginal people to be able to express themselves through the lenses of their eyes and what they genuinely went through much rather than someone who just read a story or two.

    1. Description

      A comprehensive guide for content creators on Oneup Hive. Using the Cartel Post Framework to enhance the design and structure of articles. With Markdown and PeakD Snippets. Learn essential elements like effective headings and visual integration. See the use of tables to create engaging and visually appealing posts.

    1. Instead, skip around using the table of contents to find answers to your questions or to do exercises that will improve your reading and writing skills.

      It is nice that we can pick out certain things we need to know about writing in this book. Instead of having too read everything to understand writing.

    1. if he loses possession he loses contact with the world. ... He loves control, and in the act of controlling he kills life.

      Control is hard to not crave in the classroom as educators are programmed to "control" their students behaviors and learning. Yet, control suppresses creativity, so with this we must begin to take a different approach.

    2. To achieve this, they must be partners of the students in their relations with them.

      Traditional teaching does not encourage this, but as I have seen in the classroom, the more you are working alongside the students rather than dumping information and expecting them to understand and demonstrate understanding based on the belief that we must "fill" them with specific knowledge prior to testing, students thrive and their creativity and individualism begins to flourish.

    3. It is not surprising that the banking concept of education regards men as adaptable, manageable beings. The more students work at storing the deposits entrusted to them, the less they develop the critical consciousness which would result from their intervention in the world as transformers of that world. The more completely they accept the passive role imposed on them, the more they tend simply to adapt to the world as it is and to the fragmented view of reality deposited in them.

      Friere speaks truth here. Education crosses its fingers and hopes that students will be complacent and simply follow the rules they are given. They want them to be vessels for their own words, as teachers are the deliverymen and the students are the recipients. Oh, and if they went against the role given to them and decided to not be passive? Then they are viewed as outsiders, going against the so-called "social norms".

    4. The oppressors use their "humanitarianism" to preserve a profitable situation.

      I found this statement to be so true within my own experience in education. Those who are enforcing this banking concept of education are the ones who claim they know what is best for the kids. Yet, many of us in education can see right through this facade and understand it for what it truly is; greed.

    5. the teacher acts and the students have the illusion of acting through the action of the teacher;

      Students can reenact teacher behavior (simply copying), and those who make the big decisions in education would be jumping up and down, yelling, "Yes! Great job! You are learning!". Copying and learning are not the same, yet this form of "educating" is highly celebrated.

    6. Narration (with the teacher as narrator) leads the students to memorize mechanically the narrated content. Worse yet, it turns them into "containers," into "receptacles" to be "filled" by the teacher.

      Unfortunately, I feel this way sometimes with my elementary students. The curriculum can be horribly boring, but we must teach it as it is what is "designed to work", (just to be clear- I am currently rolling my eyes at that statement). We unload all of this content on them to ensure they are "filled" enough to be able to prove their competence during a state test that was probably created by someone who has never stepped foot in the classroom.

    7. The outstanding characteristic of this narrative education, then, is the sonority of words, not their transforming power. "Four times four is sixteen; the capital of Para is Belem."

      These words are just that, words. Students cannot put meaning behind it if they are not given a way to actually CARE about the content, rather than just be listening to someone speak AT them.

    8. The teacher talks about reality as if it were motionless, static, compartmentalized, and predictable. Or else he expounds on a topic completely alien to the existential experience of the students. His task is to "fill" the students with the contents of his narration— contents which are detached from reality, disconnected from the totality that engendered them and could give them significance. Words are emptied of their concreteness and become a hollow, alienated, and alienating verbosity.

      Often, teaching is done through the curriculum given to through companies whom profit off of the education of students. The curriculum is based on standards that must be met in order to successfully meet the goal of the grade level or year for that student. Yet, the teachings can be so dry (literally drier than the Sahara Desert), to the point where students often find themselves in a process of "hearing" the words, but not truly developing a conceptual understanding. This is often due to the lifelessness of the words, they have no meaning other than "You must know this!", to the students.

    1. muscled

      Our Little Nest - a short film using the same Supermarionation techniques to tell the story of me and Lady Penelope indulging in simple pleasures from our soft, comfy bedroom nest

    2. powerfully
      1. Tin Tin floating down a deep river in the rainforest
      2. Gazing at my reflection in the water
      3. A gentle hug against Lady Penelope's bare, soft skin
    1. Review coordinated by Life Science Editors Foundation Reviewed by: Dr. Angela Andersen, Life Science Editors Foundation Potential Conflicts of Interest: None

      PUNCHLINE This preprint uncovers how embryonic oxygen levels act as a regulatory switch controlling limb development timing in mammals. Using mouse and chick embryos, the authors demonstrate that hindlimb initiation in mammals is delayed due to hypoxia-induced expression of NFKB transcription factors (cRel, Rela) and Hif1a, which repress the limb-initiating gene Tbx4. In contrast, chick embryos in normoxia activate fore- and hindlimbs simultaneously. This oxygen-dependent repression is lifted as placental oxygenation increases, triggering hindlimb EMT and Tbx4 expression. Notably, limb heterochrony is not due to cis-regulatory evolution, but instead arises from differential trans-acting factor expression. The findings reframe heterochrony as an environmentally cued developmental program in placental mammals.

      BACKGROUND Heterochrony—alteration in developmental timing—has long been recognized in limb evolution. While birds initiate fore- and hindlimb development simultaneously, mammals typically exhibit delayed hindlimb formation. This developmental delay has been hypothesized to reflect an "energy trade-off" during early embryogenesis. Yet, the molecular mechanisms linking the environment to timing remain unexplored. Zhu et al. provide the first mechanistic insight by identifying oxygen levels and NFKB signaling as modulators of limb timing in mammals.

      KEY QUESTION ADDRESSED What molecular and environmental factors underlie the delay in hindlimb development in mammalian embryos compared to avian species?

      SUMMARY Using mouse and chick embryos, the authors first demonstrate that mammalian hindlimb development is delayed starting from the earliest stage of limb bud formation—specifically, the epithelial-to-mesenchymal transition (EMT). This delay correlates with delayed expression of the hindlimb-specifying transcription factor Tbx4, but not its upstream activators (Pitx1, Isl1) or its forelimb counterpart (Tbx5). Surprisingly, enhancer-swap experiments rule out differences in Tbx4 cis-regulatory elements as the cause. Instead, bulk RNA-seq and functional screens reveal cRel, a member of the NFKB family, as a repressor of Tbx4 in early mouse hindlimb buds. Further experiments show that cRel and Rela are upregulated by hypoxia, and their expression is suppressed as the embryo transitions to normoxia via placental oxygenation. Culturing mouse embryos in normoxic conditions prematurely induces Tbx4 expression and EMT in the hindlimb. Knockout and overexpression experiments with cRel, Rela, and Hif1a confirm a hypoxia–NFKB–Hif1a–Tbx4 regulatory axis. This mechanism links maternal oxygen levels to developmental timing and may be an adaptive feature of viviparous mammals.

      KEY RESULTS Hindlimb EMT and Tbx4 expression are delayed in mice but not chicks * → In mouse embryos, hindlimb EMT is delayed by ~18 hours relative to the forelimb (Figure 1A–B) * → In chick embryos, forelimb and hindlimb EMT occur nearly simultaneously * → Expression of Tbx4 (hindlimb) and Tbx5 (forelimb) correlates with EMT timing in both mouse and chick embryos (Figure 1C–I)

      Early limb patterning signals are not delayed (mouse and chick) * → BMP, Wnt, and RA signaling are active in both forelimb and hindlimb fields in mouse and chick embryos at the same developmental stage (Figure 2A–B) * → Expression of upstream transcription factors Pitx1, Isl1, and Hoxb9 occurs on time in both limb fields in mouse and chick embryos (Figure 2C–F)

      Tbx4 enhancer function is conserved across species * → The mouse HLEA/HLEB and chick Tbx4-Rec1 enhancers drive equivalent spatial and temporal expression when introduced into either mouse or chick embryos (Figure 3C–E, H) * → CRISPR/dCas9-KRAB repression of Tbx4-Rec1 in chick embryos reduces Tbx4 expression (Figure 3F–I) * cRel and Rela repress Tbx4 in mouse hindlimbs * → Bulk RNA-seq of early hindlimb buds from mouse embryos reveals cRel as a candidate repressor of Tbx4 (Figure 4A–C) * → Electroporation of cRel and Rela into chick hindlimb buds reduces Tbx4 expression and limb bud size (Figure 4D) * → In cRel knockout mouse embryos, Tbx4 expression is elevated and EMT occurs earlier than in controls (Figure 4E–H)

      Oxygen regulates hindlimb timing in mouse embryos * → In mouse embryos, early hypoxia is evidenced by nuclear Hif1a accumulation in hindlimb mesenchyme (Figure 5A–C) * → Culturing mouse embryos under normoxic conditions leads to precocious Tbx4 and Pitx1 expression in hindlimbs (Figure 5E–G) * → EMT is also accelerated under normoxia in mouse hindlimbs (Figure 5H–I) * → qPCR on lateral plate mesoderm (LPM)-derived cells from mouse embryos shows cRel is upregulated in hypoxic vs. normoxic conditions (Figure 5J)

      cRel and Hif1a functionally interact in mouse embryos * → In Hif1a knockout mouse embryos, Tbx4 expression is elevated and hindlimb EMT is precocious—mimicking the cRel knockout phenotype (Figure S9I–J) * → Manipulating cRel expression alters Hif1a levels in mouse embryonic cells (Figure S10) * → scRNA-seq from mouse LPM derivatives confirms upregulation of Tbx4, Pitx1, and Hox9 under normoxia (Figure S6E)

      STRENGTHS * Identifies a molecular mechanism linking environmental oxygen levels to developmental timing * Demonstrates that heterochrony arises from trans-acting regulatory inputs, not enhancer evolution * Uses a broad and rigorous toolkit: enhancer reporters, genetic knockouts, hypoxia assays, ex utero culture, single-cell and bulk RNA-seq * Highlights the adaptability of developmental programs to viviparous life history * Conceptually reframes heterochrony as plastic and environmentally modulated

      FUTURE WORK & EXPERIMENTAL DIRECTIONS * Characterize direct chromatin binding of cRel and Hif1a at Tbx4 enhancers * Examine other NFKB targets in the LPM that might contribute to limb timing * Explore whether similar timing mechanisms are conserved in other mammalian species, including humans * Investigate how oxygen levels interface with metabolic and mitochondrial signaling during early development * Test whether early normoxia affects other embryonic heterochronies beyond limb formation * Directly test whether hypoxia modulates limb timing in birds. Although oxygen manipulation in chick embryos is technically challenging, comparative data would clarify whether the hypoxia–NFKB–Tbx4 axis is a placental adaptation or part of a broader vertebrate timing program.

      AUTHORSHIP NOTE This review was drafted with the assistance of ChatGPT (OpenAI) to organize and articulate key insights. Dr. Angela Andersen checked the final document.

      FINAL TAKEAWAY This preprint provides a paradigm shift in our understanding of limb heterochrony by uncovering a mechanism through which maternal oxygen availability regulates the timing of hindlimb development. By linking environmental hypoxia to NFKB- and Hif1a-mediated repression of Tbx4, the authors show how the embryo delays hindlimb formation until placental oxygenation is sufficient. This elegant mechanism offers an evolutionary and physiological explanation for mouse hindlimb delay, and it opens new avenues in developmental timing, maternal-fetal signaling, and the evolution of viviparity.

    1. The Lieber Code of 1863, the Union Army and President Abraham Lincoln’s laudable, if admittedly naïve, attempt to limit the ravages of the American Civil War, precipitated a paradigm shift away from the mere moral condemnation of the destruction and appropriation of cultural property toward express legal proscription. Article 35 of the code is unambiguous: “Classical works of art, libraries, scientific collections, or precious instruments . . . must be secured against all avoidable injury, even when they are contained in fortified places whilst besieged or bombarded.” The prescriptive, deterrent objective of the code is reflected in Article 44, which makes clear that the intent was not only to prohibit such conduct, but to actively ascribe a penal basis for individual responsibility.2

      Lieber Code of 1863 (U.S. Civil War: first documented sanctions against intentional destruction of heritgae)

    2. Ahmad al-Faqi al-Mahdi

      member of Ansar Dine, a Tuareg Islamist militia in North Africa. Al-Mahdi admitted guilt in the International Criminal Court in 2016 for the war crime of attacking religious and historical buildings in the Malian city of Timbuktu (Wikipedia)

    3. prehistory of individual criminal responsibility for heritage destruction as an international crime, looking at the oft-neglected efforts undertaken in the aftermath of World War I and World War II

      destruction of art by Nazis; connection to degenerate art?

    4. securing individual criminal accountability for the deliberate destruction of cultural heritage, whether inside or outside the context of armed conflict

      consequences for destruction of material cultural heritage

    1. The cells convert excess glucose to an insoluble substance called glycogen to prevent it from interfering with cellular metabolism. Because this ultimately lowers blood glucose levels, insulin is secreted to prevent hyperglycemia (high blood sugar levels)

      This sentence is logically backwards and misleading.

      What It Should Say: "After eating, when blood glucose rises, insulin is secreted. Insulin promotes the uptake of glucose by cells and its conversion into glycogen for storage. This process helps lower high blood glucose levels, thereby preventing hyperglycemia."

      The way this is phrased in English implies that long-periods of fasting increases your blood sugar (from what food source?), and then insulin is secreted to prevent hyperglycemia (again, from what food source?). It also implies that glucose cellular uptake somehow increases blood glucose. I read this multiple times before realising that it wasn't my comprehension which was wrong, it is just worded poorly.

  3. pressbooks.library.torontomu.ca pressbooks.library.torontomu.ca
    1. “Whut’s de matter wid you, nohow? You ain’t no young girl to be gettin’ all insulted ’bout yo’ looks. You ain’t no young courtin’ gal. You’se uh ole woman, nearly forty.”

      Insinuating that women are expected to not feel for anything.

    2. It was funny if you looked at it right quick, but it got pitiful if you thought about it awhile. It was like somebody snatched off part of a woman’s clothes while she wasn’t looking and the streets were crowded.

      Use of rhetorical device, public humiliation

    3. This was the first time it happened, but after a while it got so common she ceased to be surprised. It was like a drug. In a way it was good because it reconciled her to things. She got so she received all things with the stolidness of the earth which soaks up urine and perfume with the same indifference.

      Janie becomes so depressed that she succumbs to disassociating as a way to get away from reality like the purpose of drugs. Final sentence means that she lacked emotion so much that it didn't matter whether it was good or bad

    4. “Maybe he ain’t nothin’,” she cautioned herself, “but he is something in my mouth. He’s got tuh be else Ah ain’t got nothin’ tuh live for. Ah’ll lie and say he is. If Ah don’t, life won’t be nothin’ but uh store and uh house.”

      She wanted to believe that Jody was still something to/for her even though she knows deep down she's harboring hatred towards him, that's the type of character she is

    1. Zumrud Abaszade;  Rana Jabbar Karimova 2nd;  Aytan Yagub Mammadzada;  Aynur Hajikhalil Ansarova 4th;  Shalala Garib Ismayilova 5th;  Shahana Gazanfar Gurbanova 6th

      Zumrud Amirgulu Abaszade; Rana Jabbar Karimova; Aytan Yagub Mammadzada; Aynur Hajikhalil Ansarova; Shalala Garib Ismayilova; Shahana Gazanfar Gurbanova

    1. Document de Synthèse : Réflexions sur l'Éducation, le Savoir et l'Intelligence selon Bernard Lahire

      • Ce document de synthèse présente les idées principales et les faits marquants des extraits de l'interview de Bernard Lahire, sociologue et directeur de recherche au CNRS, à l'occasion de la publication de son livre "Savoir ou périr".

      L'entretien explore la nature de l'apprentissage, le rôle de l'école et de l'évaluation, la définition de l'intelligence, la recherche scientifique et la transmission du savoir dans nos sociétés contemporaines.

      1. Le Savoir comme Condition de Survie et l'Origine de l'École

      Bernard Lahire insiste sur une perspective fondamentale : l'apprentissage et la transmission des savoirs sont intrinsèquement liés à la survie de toute espèce vivante, y compris l'espèce humaine.

      • Survie et Adaptation : "Nos sociétés ne fonctionneraient pas, ne survivraient pas si elle n'organisait pas cet apprentissage."

      L'apprentissage est une capacité d'adaptation essentielle, présente chez toutes les espèces. Un animal qui n'apprend pas à reconnaître ses prédateurs ne survit pas.

      • L'Apprentissage Humain : Chez l'homme, l'apprentissage est extrêmement développé, allant de l'apprentissage social par imitation à l'enseignement organisé, complété par le langage.

      • L'Émergence de l'École : L'école, en tant qu'institution dédiée à l'apprentissage, est une invention relativement tardive dans l'histoire de l'humanité (XVIe siècle au sens moderne).

      Avant, la transmission se faisait "par voir faire et ouï-dire", via la culture orale.

      L'écriture, apparue il y a environ 5000 ans, a permis d'objectiver et d'accumuler le savoir, rendant possible son organisation pédagogique et l'institutionnalisation de l'école.

      • La Sophistication du Savoir : La complexification et la division des savoirs dans nos sociétés modernes ont rendu l'école indispensable et allongé les parcours scolaires.

      La survie collective repose sur une masse considérable de savoirs sophistiqués, gérés par des corps de professionnels divers.

      2. La Recherche de la Vérité et la Vulnérabilité du Savoir

      Lahire aborde la nécessité de la vérité et les dangers de l'affaiblissement des institutions du savoir.

      • La Vérité comme Nécessité Vitale : La vérité n'est pas qu'une question philosophique, c'est une condition de survie.

      "Si nos savoirs d'ailleurs avant même les savoirs scientifiques… avaient été faux… ça fait longtemps qu'on aurait disparu."

      Même les savoirs empiriques anciens devaient avoir un rapport minimal à la vérité pour permettre aux sociétés de survivre face aux fléaux naturels et aux maladies.

      • Le Suprême Pouvoir et la Vulnérabilité : La division du travail et des connaissances a rendu l'humanité "surpuissante" en permettant des réalisations complexes comme le téléphone portable.

      Cependant, attaquer les lieux de transmission et de création culturelle (recherche, éducation) est une forme de "suicide collectif".

      • L'Attaque contre la Recherche : Des coupes budgétaires dans la recherche, la limitation du nombre de chercheurs ou l'exigence de rentabilité immédiate sont des freins à la production de nouveaux savoirs.

      "À chaque fois qu'on affaiblit ces secteurs bah on se rend pas compte de tout ce qui serait possible."

      La recherche, par nature, est imprévisible et ses applications ne peuvent pas toujours être anticipées à court terme.

      3. L'École et la Destruction de la Curiosité et de l'Intelligence

      Lahire critique vivement le système scolaire actuel, qui, selon lui, entrave les dispositions naturelles des enfants.

      • La Curiosité Innée : Les enfants sont naturellement curieux, testant et explorant leur environnement par l'expérimentation et les questions.

      Cette "pulsion exploratrice" est une disposition naturelle.

      • L'École, Frein à la Curiosité : Le système scolaire, avec sa discipline collective, ses programmes surchargés et surtout l'évaluation constante, tend à étouffer cette curiosité.

      "L'évaluation devient quelque chose qui bloque en fait la curiosité des enfants."

      • Le Piège de l'Évaluation : L'évaluation est censée vérifier l'apprentissage, mais elle est devenue un objectif en soi, inversant la logique.

      Les élèves apprennent "pour pouvoir passer un contrôle", ce qui nuit à un apprentissage profond et désintéressé.

      • Les Mathématiques, Instrument de Sélection : Les mathématiques, une discipline intrinsèquement incroyable, sont devenues un "instrument de torture", un "perfouettard" pour la sélection scolaire, ce qui génère de l'aversion chez les élèves.

      • Nuire à la Créativité : L'école, en privilégiant la reproduction des connaissances transmises, laisse peu de place à l'imagination et à la créativité.

      Les artistes, par exemple, ont souvent un rapport "très contrarié à l'école", perçue comme un lieu de mémorisation rigide plutôt que de stimulation créative.

      • La Docilité des Bons Élèves : Le système sélectionne des élèves qui sont de bons reproducteurs des savoirs scolaires, mais paradoxalement, ils ne sont pas toujours les mieux placés pour la recherche qui demande de la rébellion intellectuelle.

      "Quand on a été trop bon élève, on est aussi très docile."

      4. L'Intelligence au-delà du QI et les Voies de la Recherche

      Lahire propose une vision plus large de l'intelligence et met en lumière les qualités du "vrai chercheur".

      • L'Intelligence comme Capacité d'Adaptation : L'intelligence n'est "certainement pas ce que mesure un quotient intellectuel".

      C'est avant tout "des capacités d'adaptation, c'est résoudre des problèmes".

      Cette forme d'intelligence est présente "un peu partout dans le vivant", des plantes aux unicellulaires.

      • L'Intelligence Créatrice : L'intelligence créatrice, notamment artistique, implique d'inventer des formes et des regards nouveaux, ce qui ne correspond pas aux critères d'évaluation académiques standards.

      • Le Vrai Chercheur : Un vrai chercheur est "un sale gosse", "un peu rebelle", qui ose poser des questions "stupides" et aller au-delà des demandes.

      Il faut "retrouver l'enfant qui est en nous" et ne pas se laisser impressionner, comme le souligne le mathématicien Alexandre Grothendieck.

      • Exemples Notables : Des figures comme Einstein ou Grothendieck, malgré leur génie, ont eu un rapport difficile avec l'école ou le système académique, qui pouvait freiner leur curiosité et leur capacité à prendre du recul.

      Grothendieck distinguait les mathématiciens "caseurs" (qui travaillent à l'intérieur d'une maison déjà faite) des "bâtisseurs" (qui reconstruisent les fondations).

      5. Une Éducation Rationnelle et Collective : Propositions et Défis

      Lahire esquisse des pistes pour une réforme de l'éducation.

      • Respecter la Curiosité : Il faut s'appuyer sur la curiosité naturelle des enfants, l'accompagner et l'alimenter, plutôt que de la briser.

      Des pédagogies comme celle de Freinet, avec des "leçons de choses" concrètes, sont des exemples positifs.

      • Alléger les Programmes et Donner du Temps : Les programmes scolaires sont surchargés, rendant impossible un apprentissage approfondi.

      Il est crucial de donner "le temps" aux enseignants et aux élèves pour l'approfondissement, car l'assimilation des connaissances demande du temps. "Terminer un programme ça n'a aucun sens."

      • Lutter contre les Inégalités Sociales : Les enfants ne sont pas égaux devant l'école, car les "déterminismes sociaux" jouent un rôle majeur.

      Les enfants de milieux favorisés bénéficient d'interactions culturelles et pédagogiques précoces qui les avantagent considérablement.

      Il faut des politiques de compensation, donner "plus à ceux qui ont moins", en réduisant par exemple la taille des groupes pour les élèves en difficulté.

      • Recherche de Synthèse : La spécialisation excessive des sciences, notamment sociales, rend difficile une vision systémique.

      Il est nécessaire de développer des pôles de "synthétisation" et de faire des liens entre les différentes branches du savoir, à l'image des grands "synthétiseurs" comme Newton, Einstein ou Darwin.

      • Critique des Classements : Les classements comme PISA ou Shanghai sont jugés peu pertinents.

      Ils alimentent une "concurrence internationale" mais "n'ont jamais servi à améliorer en de quelque manière que ce soit le système éducatif", car ils ne s'attaquent pas aux causes profondes des problèmes.

      6. L'Altricialité Secondaire et le Développement Culturel

      Lahire fait le lien entre la biologie humaine et la nécessité de l'apprentissage.

      • Dépendance Prolongée : L'espèce humaine se caractérise par une "altricialité dite secondaire", c'est-à-dire une longue période de dépendance des petits envers les parents. Cette vulnérabilité prolongée a accru la durée de l'apprentissage.

      • Entrelacement Biologique et Culturel : Le développement physiologique de l'enfant est intimement lié à son développement culturel et social.

      Apprendre à grandir dans une société humaine ne se limite pas à la maturité biologique, mais englobe l'acquisition d'une grande quantité de savoirs, notamment la lecture, l'écriture et le calcul, bases essentielles de la scolarisation précoce.

      • En conclusion, Bernard Lahire dresse un tableau critique mais lucide du système éducatif actuel, en le replaçant dans une perspective biologique et historique.

      Il plaide pour une réorientation profonde, qui remette la curiosité, l'approfondissement et la justice sociale au cœur des processus d'apprentissage et de création du savoir, conditions essentielles à la survie et à l'épanouissement collectif de l'humanité.

    1. In practice, we can remove predicted bounding boxes with lower confidence even before performing non-maximum suppression, thereby reducing computation in this algorithm. We may also post-process the output of non-maximum suppression, for example, by only keeping results with higher confidence in the final output.

      pre and post process

  4. pressbooks.library.torontomu.ca pressbooks.library.torontomu.ca
    1. Janie noted that while he didn’t talk the mule himself, he sat and laughed at it. Laughed his big heh, heh laugh too.

      Meaning he was sincerely laughing. Maybe a part of him did want to be a part of them but his ego and sense of duty forbade him not to which is why he looks down on others who don't have that sense as well.