We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]).
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Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study
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RRID:AB_2203289
DOI: 10.7554/eLife.57763
Resource: (Abcam Cat# ab50595, RRID:AB_2203289)
Curator: @evieth
SciCrunch record: RRID:AB_2203289
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-
elifesciences.org elifesciences.org
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RRID:AB_10853189
DOI: 10.7554/eLife.56882
Resource: (Thermo Fisher Scientific Cat# 47-0193-82, RRID:AB_10853189)
Curator: @evieth
SciCrunch record: RRID:AB_10853189
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RRID:AB_10598809
DOI: 10.7554/eLife.56882
Resource: (Thermo Fisher Scientific Cat# 17-5886-82, RRID:AB_10598809)
Curator: @evieth
SciCrunch record: RRID:AB_10598809
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elifesciences.org elifesciences.org
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RRID:AB_887818
DOI: 10.7554/eLife.56469
Resource: (Synaptic Systems Cat# 103 002, RRID:AB_887818)
Curator: @Naa003
SciCrunch record: RRID:AB_887818
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RRID:Addgene_106175
DOI: 10.7554/eLife.56469
Resource: RRID:Addgene_106175
Curator: @Naa003
SciCrunch record: RRID:Addgene_106175
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RRID:AB_2619757
DOI: 10.7554/eLife.56469
Resource: (Synaptic Systems Cat# 104 211C5, RRID:AB_2619757)
Curator: @Naa003
SciCrunch record: RRID:AB_2619757
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elifesciences.org elifesciences.org
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RRID:AB_2107780
DOI: 10.7554/eLife.42386
Resource: (Cell Signaling Technology Cat# 9743, RRID:AB_2107780)
Curator: @evieth
SciCrunch record: RRID:AB_2107780
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elifesciences.org elifesciences.org
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RRID:SCR_003070
DOI: 10.7554/eLife.47551
Resource: ImageJ (RRID:SCR_003070)
Curator: @evieth
SciCrunch record: RRID:SCR_003070
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RRID:SCR_001622
DOI: 10.7554/eLife.47551
Resource: MATLAB (RRID:SCR_001622)
Curator: @evieth
SciCrunch record: RRID:SCR_001622
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-
elifesciences.org elifesciences.org
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RRID:AB_831602
DOI: 10.7554/eLife.51002
Resource: (Santa Cruz Biotechnology Cat# sc-53993, RRID:AB_831602)
Curator: @evieth
SciCrunch record: RRID:AB_831602
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elifesciences.org elifesciences.org
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RRID:AB_297217
DOI: 10.7554/eLife.29112
Resource: (Abcam Cat# ab10479, RRID:AB_297217)
Curator: @Naa003
SciCrunch record: RRID:AB_297217
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elifesciences.org elifesciences.org
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AB_141930
DOI: 10.7554/eLife.42914
Resource: (Molecular Probes Cat# A-11076, RRID:AB_141930)
Curator: @evieth
SciCrunch record: RRID:AB_141930
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elifesciences.org elifesciences.org
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RRID:AB_1549585
DOI: 10.7554/eLife.35012
Resource: (Cell Signaling Technology Cat# 3724, RRID:AB_1549585)
Curator: @evieth
SciCrunch record: RRID:AB_1549585
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elifesciences.org elifesciences.org
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RRID:Addgene_117072
DOI: 10.7554/eLife.44161
Resource: RRID:Addgene_117072
Curator: @evieth
SciCrunch record: RRID:Addgene_117072
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RRID:AB_2756824
DOI: 10.7554/eLife.44161
Resource: (Cell Signaling Technology Cat# 97166, RRID:AB_2756824)
Curator: @evieth
SciCrunch record: RRID:AB_2756824
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RRID:AB_2072132
DOI: 10.7554/eLife.44161
Resource: (Cell Signaling Technology Cat# 4138, RRID:AB_2072132)
Curator: @evieth
SciCrunch record: RRID:AB_2072132
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RRID:IMSR_TAC:ncrnu
DOI: 10.7554/eLife.44161
Resource: (IMSR Cat# TAC_ncrnu,RRID:IMSR_TAC:ncrnu)
Curator: @evieth
SciCrunch record: RRID:IMSR_TAC:ncrnu
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viahtml.hypothes.is viahtml.hypothes.is
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RRID:AB_2534096
DOI: 10.7554/eLife.26519
Resource: (Thermo Fisher Scientific Cat# A-11039, RRID:AB_2534096)
Curator: @Naa003
SciCrunch record: RRID:AB_2534096
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elifesciences.org elifesciences.org
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RRID:AB_397781
DOI: 10.7554/eLife.55164
Resource: (BD Biosciences Cat# 610398, RRID:AB_397781)
Curator: @evieth
SciCrunch record: RRID:AB_397781
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elifesciences.org elifesciences.org
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RRID:IMSR_JAX:006410
DOI: 10.7554/eLife.35657
Resource: (IMSR Cat# JAX_006410,RRID:IMSR_JAX:006410)
Curator: @Naa003
SciCrunch record: RRID:IMSR_JAX:006410
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elifesciences.org elifesciences.org
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RRID:SCR_002285
DOI: 10.7554/eLife.38137
Resource: Fiji (RRID:SCR_002285)
Curator: @evieth
SciCrunch record: RRID:SCR_002285
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RRID:AB_2620155
DOI: 10.7554/eLife.38137
Resource: (Thermo Fisher Scientific Cat# A22287, RRID:AB_2620155)
Curator: @evieth
SciCrunch record: RRID:AB_2620155
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elifesciences.org elifesciences.org
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RRID:AB_329827
DOI: 10.7554/eLife.37993
Resource: (Cell Signaling Technology Cat# 9272, RRID:AB_329827)
Curator: @evieth
SciCrunch record: RRID:AB_329827
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RRID:AB_331682
DOI: 10.7554/eLife.37993
Resource: (Cell Signaling Technology Cat# 2215, RRID:AB_331682)
Curator: @evieth
SciCrunch record: RRID:AB_331682
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RRID:AB_2315049
DOI: 10.7554/eLife.37993
Resource: (Cell Signaling Technology Cat# 4060, RRID:AB_2315049)
Curator: @evieth
SciCrunch record: RRID:AB_2315049
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elifesciences.org elifesciences.org
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RRID:AB_331646
DOI: 10.7554/eLife.53367
Resource: (Cell Signaling Technology Cat# 9101, RRID:AB_331646)
Curator: @Naa003
SciCrunch record: RRID:AB_331646
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RRID:AB_331284
DOI: 10.7554/eLife.53367
Resource: (Cell Signaling Technology Cat# 3033, RRID:AB_331284)
Curator: @Naa003
SciCrunch record: RRID:AB_331284
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elifesciences.org elifesciences.org
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RRID:AB_10896291
DOI: 10.7554/eLife.54659
Resource: AB_10896291
Curator: @evieth
SciCrunch record: RRID:AB_10896291
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RRID:AB_467251
DOI: 10.7554/eLife.54659
Resource: (Thermo Fisher Scientific Cat# 14-0451-82, RRID:AB_467251)
Curator: @evieth
SciCrunch record: RRID:AB_467251
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RRID:SCR_001905
DOI: 10.7554/eLife.54659
Resource: R Project for Statistical Computing (RRID:SCR_001905)
Curator: @evieth
SciCrunch record: RRID:SCR_001905
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RRID:AB_10717261
DOI: 10.7554/eLife.54659
Resource: (Thermo Fisher Scientific Cat# 17-1351-82, RRID:AB_10717261)
Curator: @evieth
SciCrunch record: RRID:AB_10717261
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elifesciences.org elifesciences.org
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RRID:AB_2571595
DOI: 10.7554/eLife.51093
Resource: (Frontier Institute Cat# D1R-GP, RRID:AB_2571595)
Curator: @Naa003
SciCrunch record: RRID:AB_2571595
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Addgene_12259
DOI: 10.7554/eLife.51093
Resource: RRID:Addgene_12259
Curator: @Naa003
SciCrunch record: RRID:Addgene_12259
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elifesciences.org elifesciences.org
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RRID:AB_476976
DOI: 10.7554/eLife.40392
Resource: (Sigma-Aldrich Cat# F3648, RRID:AB_476976)
Curator: @evieth
SciCrunch record: RRID:AB_476976
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elifesciences.org elifesciences.org
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RRID:SCR_003005
DOI: 10.7554/eLife.50267
Resource: CRAN (RRID:SCR_003005)
Curator: @evieth
SciCrunch record: RRID:SCR_003005
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RRID:SCR_015718
DOI: 10.7554/eLife.50267
Resource: RandomForest Package in R (RRID:SCR_015718)
Curator: @evieth
SciCrunch record: RRID:SCR_015718
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elifesciences.org elifesciences.org
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RRID:SCR_006506
DOI: 10.7554/eLife.28560
Resource: Electron Microscopy Data Bank at PDBe (RRID:SCR_006506)
Curator: @Naa003
SciCrunch record: RRID:SCR_006506
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RRID:SCR_014226
DOI: 10.7554/eLife.28560
Resource: MolProbity (RRID:SCR_014226)
Curator: @Naa003
SciCrunch record: RRID:SCR_014226
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-
elifesciences.org elifesciences.org
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RRID:AB_390204
DOI: 10.7554/eLife.59328
Resource: (Millipore Cat# AB152, RRID:AB_390204)
Curator: @evieth
SciCrunch record: RRID:AB_390204
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RRID:SCR_001622
DOI: 10.7554/eLife.59328
Resource: MATLAB (RRID:SCR_001622)
Curator: @evieth
SciCrunch record: RRID:SCR_001622
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RRID:SCR_003070
DOI: 10.7554/eLife.59328
Resource: ImageJ (RRID:SCR_003070)
Curator: @evieth
SciCrunch record: RRID:SCR_003070
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RRID:AB_2313500
DOI: 10.7554/eLife.59328
Resource: (Thermo Fisher Scientific Cat# S-21375, RRID:AB_2313500)
Curator: @evieth
SciCrunch record: RRID:AB_2313500
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elifesciences.org elifesciences.org
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RRID:AB_2534079
DOI: 10.7554/eLife.56811
Resource: (Thermo Fisher Scientific Cat# A-11012, RRID:AB_2534079)
Curator: @evieth
SciCrunch record: RRID:AB_2534079
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elifesciences.org elifesciences.org
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AB_1310022
DOI: 10.7554/eLife.16011
Resource: (Abcam Cat# ab75801, RRID:AB_1310022)
Curator: @Naa003
SciCrunch record: RRID:AB_1310022
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elifesciences.org elifesciences.org
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RRID:SCR_015687
DOI: 10.7554/eLife.43738
Resource: DESeq2 (RRID:SCR_015687)
Curator: @evieth
SciCrunch record: RRID:SCR_015687
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RRID:SCR_016582
DOI: 10.7554/eLife.43738
Resource: kallisto (RRID:SCR_016582)
Curator: @evieth
SciCrunch record: RRID:SCR_016582
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RRID:AB_945678
DOI: 10.7554/eLife.43738
Resource: (Abcam Cat# ab49602, RRID:AB_945678)
Curator: @evieth
SciCrunch record: RRID:AB_945678
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elifesciences.org elifesciences.org
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RRID:SCR_002798
DOI: 10.7554/eLife.39925
Resource: GraphPad Prism (RRID:SCR_002798)
Curator: @evieth
SciCrunch record: RRID:SCR_002798
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RRID:SCR_003070
DOI: 10.7554/eLife.39925
Resource: ImageJ (RRID:SCR_003070)
Curator: @evieth
SciCrunch record: RRID:SCR_003070
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-
elifesciences.org elifesciences.org
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RRID:SCR_015655
DOI: 10.7554/eLife.28811
Resource: R package: nlme (RRID:SCR_015655)
Curator: @Naa003
SciCrunch record: RRID:SCR_015655
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RRID:SCR_015656
DOI: 10.7554/eLife.28811
Resource: R package: lmerTest (RRID:SCR_015656)
Curator: @Naa003
SciCrunch record: RRID:SCR_015656
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RRID:SCR_001905
DOI: 10.7554/eLife.28811
Resource: R Project for Statistical Computing (RRID:SCR_001905)
Curator: @Naa003
SciCrunch record: RRID:SCR_001905
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-
elifesciences.org elifesciences.org
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RRID:AB_2239535
DOI: 10.7554/eLife.35786
Resource: (Cell Signaling Technology Cat# 9585, RRID:AB_2239535)
Curator: @Naa003
SciCrunch record: RRID:AB_2239535
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AB_2200834
DOI: 10.7554/eLife.35786
Resource: (R and D Systems Cat# AF4744, RRID:AB_2200834)
Curator: @Naa003
SciCrunch record: RRID:AB_2200834
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RRID:SCR_002285
DOI: 10.7554/eLife.35786
Resource: Fiji (RRID:SCR_002285)
Curator: @Naa003
SciCrunch record: RRID:SCR_002285
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elifesciences.org elifesciences.org
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RRID:AB_2277644
DOI: 10.7554/eLife.38389
Resource: (Abcam Cat# ab5070, RRID:AB_2277644)
Curator: @evieth
SciCrunch record: RRID:AB_2277644
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elifesciences.org elifesciences.org
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RRID:SCR_008394
DOI: 10.7554/eLife.55913
Resource: Python Programming Language (RRID:SCR_008394)
Curator: @Naa003
SciCrunch record: RRID:SCR_008394
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RRID:SCR_018317
DOI: 10.7554/eLife.55913
Resource: Conda (RRID:SCR_018317)
Curator: @Naa003
SciCrunch record: RRID:SCR_018317
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elifesciences.org elifesciences.org
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RRID:CVCL_1926
DOI: 10.7554/eLife.42143
Resource: (ATCC Cat# CRL-11268, RRID:CVCL_1926)
Curator: @evieth
SciCrunch record: RRID:CVCL_1926
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elifesciences.org elifesciences.org
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RRID:AB_2295648
DOI: 10.7554/eLife.57381
Resource: (Proteintech Cat# 17460-1-AP, RRID:AB_2295648)
Curator: @evieth
SciCrunch record: RRID:AB_2295648
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RRID:AB_531794
DOI: 10.7554/eLife.57381
Resource: (DSHB Cat# 74.5A5, RRID:AB_531794)
Curator: @evieth
SciCrunch record: RRID:AB_531794
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elifesciences.org elifesciences.org
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RRID:SCR_006459
DOI: 10.7554/eLife.50004
Resource: Jalview (RRID:SCR_006459)
Curator: @evieth
SciCrunch record: RRID:SCR_006459
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elifesciences.org elifesciences.org
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RRID:AB_390780
DOI: 10.7554/eLife.53995
Resource: (Cell Signaling Technology Cat# 4696, RRID:AB_390780)
Curator: @evieth
SciCrunch record: RRID:AB_390780
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elifesciences.org elifesciences.org
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RRID:AB_1587367
DOI: 10.7554/eLife.58215
Resource: (Millipore Cat# AB2237, RRID:AB_1587367)
Curator: @evieth
SciCrunch record: RRID:AB_1587367
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RRID:SCR_013672
DOI: 10.7554/eLife.58215
Resource: ZEN Digital Imaging for Light Microscopy (RRID:SCR_013672)
Curator: @evieth
SciCrunch record: RRID:SCR_013672
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elifesciences.org elifesciences.org
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RRID:AB_2088494
DOI: 10.7554/eLife.59733
Resource: (Santa Cruz Biotechnology Cat# sc-8066, RRID:AB_2088494)
Curator: @evieth
SciCrunch record: RRID:AB_2088494
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elifesciences.org elifesciences.org
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RRID:SCR_001622
DOI: 10.7554/eLife.53552
Resource: MATLAB (RRID:SCR_001622)
Curator: @evieth
SciCrunch record: RRID:SCR_001622
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elifesciences.org elifesciences.org
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RRID:SCR_000305
DOI: 10.7554/eLife.55438
Resource: PyMOL (RRID:SCR_000305)
Curator: @Naa003
SciCrunch record: RRID:SCR_000305
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RRID:SCR_014246
DOI: 10.7554/eLife.55438
Resource: ImageQuant (RRID:SCR_014246)
Curator: @Naa003
SciCrunch record: RRID:SCR_014246
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elifesciences.org elifesciences.org
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RRID:CVCL_9773
DOI: 10.7554/eLife.38430
Resource: (RRID:CVCL_9773)
Curator: @Naa003
SciCrunch record: RRID:CVCL_9773
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elifesciences.org elifesciences.org
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RRID:AB_390918
DOI: 10.7554/eLife.58499
Resource: (Roche Cat# 11867423001, RRID:AB_390918)
Curator: @Naa003
SciCrunch record: RRID:AB_390918
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RRID:AB_2534023
DOI: 10.7554/eLife.58499
Resource: (Thermo Fisher Scientific Cat# A10262, RRID:AB_2534023)
Curator: @Naa003
SciCrunch record: RRID:AB_2534023
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elifesciences.org elifesciences.org
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RRID:IMSR_JAX:007909
DOI: 10.7554/eLife.52419
Resource: (IMSR Cat# JAX_007909,RRID:IMSR_JAX:007909)
Curator: @Naa003
SciCrunch record: RRID:IMSR_JAX:007909
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RRID:SCR_014199
DOI: 10.7554/eLife.52419
Resource: Adobe Photoshop (RRID:SCR_014199)
Curator: @Naa003
SciCrunch record: RRID:SCR_014199
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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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RRID:AB_2341188
DOI: 10.7554/eLife.51859
Resource: (Cell Signaling Technology Cat# 9661, RRID:AB_2341188)
Curator: @evieth
SciCrunch record: RRID:AB_2341188
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RRID:AB_10703265
DOI: 10.7554/eLife.51859
Resource: (Rockland Cat# 610-145-002, RRID:AB_10703265)
Curator: @evieth
SciCrunch record: RRID:AB_10703265
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elifesciences.org elifesciences.org
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RRID:CVCL_7226
DOI: 10.7554/eLife.31054
Resource: (RRID:CVCL_7226)
Curator: @Naa003
SciCrunch record: RRID:CVCL_7226
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elifesciences.org elifesciences.org
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RRID:IMSR_JAX:008464
DOI: 10.7554/eLife.29144
Resource: (IMSR Cat# JAX_008464,RRID:IMSR_JAX:008464)
Curator: @Naa003
SciCrunch record: RRID:IMSR_JAX:008464
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RRID:IMSR_EM:06370
DOI: 10.7554/eLife.29144
Resource: (IMSR Cat# EM_06370,RRID:IMSR_EM:06370)
Curator: @Naa003
SciCrunch record: RRID:IMSR_EM:06370
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elifesciences.org elifesciences.org
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RRID:AB_300798
DOI: 10.7554/eLife.42633
Resource: (Abcam Cat# ab13970, RRID:AB_300798)
Curator: @evieth
SciCrunch record: RRID:AB_300798
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elifesciences.org elifesciences.org
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RRID:AB_291280
DOI: 10.7554/eLife.28563
Resource: (Covance Cat# MMS-112R-500, RRID:AB_291280)
Curator: @Naa003
SciCrunch record: RRID:AB_291280
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elifesciences.org elifesciences.org
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AB_776911
DOI: 10.7554/eLife.31723
Resource: (Abcam Cat# ab31930, RRID:AB_776911)
Curator: @Naa003
SciCrunch record: RRID:AB_776911
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RRID:CVCL_Y019
DOI: 10.7554/eLife.31723
Resource: (RRID:CVCL_Y019)
Curator: @Naa003
SciCrunch record: RRID:CVCL_Y019
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elifesciences.org elifesciences.org
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RRID:AB_561053
DOI: 10.7554/eLife.59151
Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)
Curator: @evieth
SciCrunch record: RRID:AB_561053
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elifesciences.org elifesciences.org
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RRID:AB_2783521
DOI: 10.7554/eLife.42528
Resource: (Abcam Cat# ab203394, RRID:AB_2783521)
Curator: @evieth
SciCrunch record: RRID:AB_2783521
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elifesciences.org elifesciences.org
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RRID:AB_10002148
DOI: 10.7554/eLife.29914
Resource: (Novus Cat# NB100-355, RRID:AB_10002148)
Curator: @Naa003
SciCrunch record: RRID:AB_10002148
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RRID:AB_2535844
DOI: 10.7554/eLife.29914
Resource: (Thermo Fisher Scientific Cat# A-21422, RRID:AB_2535844)
Curator: @Naa003
SciCrunch record: RRID:AB_2535844
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elifesciences.org elifesciences.org
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RRID:AB_399854
DOI: 10.7554/eLife.52378
Resource: (BD Biosciences Cat# 612563, RRID:AB_399854)
Curator: @evieth
SciCrunch record: RRID:AB_399854
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elifesciences.org elifesciences.org
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JAX:022486
DOI: 10.7554/eLife.33051
Resource: (IMSR Cat# JAX_022486,RRID:IMSR_JAX:022486)
Curator: @evieth
SciCrunch record: RRID:IMSR_JAX:022486
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elifesciences.org elifesciences.org
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RRID:AB_10949298
DOI: 10.7554/eLife.55995
Resource: (Bio X Cell Cat# BE0108, RRID:AB_10949298)
Curator: @evieth
SciCrunch record: RRID:AB_10949298
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elifesciences.org elifesciences.org
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RRID:SCR_016732
DOI: 10.7554/eLife.59038
Resource: CTFFIND (RRID:SCR_016732)
Curator: @evieth
SciCrunch record: RRID:SCR_016732
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elifesciences.org elifesciences.org
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RRID:AB_2728733
DOI: 10.7554/eLife.39823
Resource: (Proteintech Cat# 16820-1-AP, RRID:AB_2728733)
Curator: @evieth
SciCrunch record: RRID:AB_2728733
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elifesciences.org elifesciences.org
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RRID:IMSR_JAX:028863
DOI: 10.7554/eLife.44548
Resource: (IMSR Cat# JAX_028863,RRID:IMSR_JAX:028863)
Curator: @evieth
SciCrunch record: RRID:IMSR_JAX:028863
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elifesciences.org elifesciences.org
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RRID:AB_301438
DOI: 10.7554/eLife.35878
Resource: (Abcam Cat# ab14730, RRID:AB_301438)
Curator: @evieth
SciCrunch record: RRID:AB_301438
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elifesciences.org elifesciences.org
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RRID:AB_221569
DOI: 10.7554/eLife.35989
Resource: (Molecular Probes Cat# A-11122, RRID:AB_221569)
Curator: @Naa003
SciCrunch record: RRID:AB_221569
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elifesciences.org elifesciences.org
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RRID:AB_2340846
DOI: 10.7554/eLife.55289
Resource: (Jackson ImmunoResearch Labs Cat# 715-545-150, RRID:AB_2340846)
Curator: @evieth
SciCrunch record: RRID:AB_2340846
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elifesciences.org elifesciences.org
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RRID:AB_662870
DOI: 10.7554/eLife.52612
Resource: (Covance Cat# SIG-39138-050, RRID:AB_662870)
Curator: @evieth
SciCrunch record: RRID:AB_662870
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elifesciences.org elifesciences.org
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RRID:AB_477593
DOI: 10.7554/eLife.54927
Resource: (Sigma-Aldrich Cat# T9026, RRID:AB_477593)
Curator: @evieth
SciCrunch record: RRID:AB_477593
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elifesciences.org elifesciences.org
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RRID:CVCL_0549
DOI: 10.7554/eLife.58823
Resource: (BCRC Cat# 60011, RRID:CVCL_0549)
Curator: @evieth
SciCrunch record: RRID:CVCL_0549
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