for - quote - myth - Richard Dawkin myth - recreate entire organism from DNA - not possible - Denis Noble

quote - myth - Richard Dawkin myth - recreate entire organism from DNA - not possible - Denis Noble - (see below) - As Richard Dawkins told me two years ago in a debate with him: - "Denis, we could inscribe your DNA in blocks of granite, - the C's G's A's and T's, - and we' keep those blocks of granite for 10,000 years and then we'll be able to recreate you." - I said no you can't - why not? - Well, where would you get my mother's egg cell, as it was in1936 - Well you can see that the point here, it led people to a very simplistic idea that from DNA you could automatically recreate a person, an organism exactly as it is in its first, Incarnation if you like - We can all be reincarnated as many times as we wish!<br /> - Well, one one might sort of wish to be a bit of a Buddhist in all of this and get away with that, - but I don't think even the Buddhists would accept that that was the way they were going to do it if they do it at all

for - spiritual seeking in modernity - initiation first stage body - John Churchill - meaning crisis - spiritual initiation - first stage - body - John Churchill - initiation - first stage - body - example - yoga and green juice - getting stuck here is possible - John Churchill - meaning crisis - spiritual initiation - first stage - body - John Churchill

Disease: mild haemophilia A, influencing VWF levels

Patient: 20 yo, Female

Variant1: F8 NM_000132.3: c.1127T>G: p. Val376Gly (Exon 8, current clinvar interpretation not available)

Variant 2: F8 NM_000132.3: c.3780C>G: p. Asp1260Glu (Exon 14, current ClinVar interpretation is benign)

Variant 3: VWF NM_000552.5: c.1415A>G:p.His484Arg (Exon 13, current ClinVar interpretation is Benign/likely Benign)

Variant 4: VWF NM_000552.5: c.2365A>G:p.Thr789Ala (Exon 18, current ClinVar interpretation is Benign/ likely Benign)

Variant 5: VWF NM_000552.5: c.2771G>A:p.Arg924Gln (Exon 21, current ClinVar interpretation is conflicting interpretations of pathogenicity (VUS-3)(Benign-4)(Likely benign-1))

Variant 6: VWF NM_000552.5: c.4141A>G:p.Thr1381Ala (Exon 28, current ClinVar interpretation is Benign/ Likely Benign)

Variant 7: VWF NM_000552.5: c.6532G>T:p.Ala2178Ser (Exon 37, Conflicting interpretations of pathogenicity: (VUS-1) (Likely Benign-1))

Variant 8: F5 NM_000130.5: c.2773A>G:p.Lys925Glu (Exon 13, current ClinVar interpretation is Benign/Likely Benign)

Variant 9: F5 NM_000130.5: c.2594A>G:p.His865Arg (Exon 13, current ClinVar interpretation is Benign/Likely Benign)

Variant 10: F5 NM_000130.5: c.2573A>G:p.Lys858Arg (Exon 13, Conflicting interpretations of pathogenicity: (VUS-1) (Benign-2)(Likely Benign-1))

Variant 11: F5 NM_000130.5: c.5290A>G:p.Met1764Val (Exon 16, Conflicting interpretations of pathogenicity: (VUS-1) (Benign-2)(Likely Benign-1))

Variant 12: F13A1 NM_000129.4: c.103G>T:p.Val35Leu (Exon 2, Conflicting interpretations of pathogenicity: (VUS-1) (Benign-3))

Variant notes: All are heterozygous

Both variants in F8 are linked to reports associated with haemophilia, though second variant is considered benign.

Phenotypes: History of bleeding (Heavy mentrual bleeding since menarche)(Treated with transdermal oestrogen and Levonorgestel), iron deficiency anaemia. High Janssen score for pictorial blood assessment. Gum bleeding lasting longer than 10 minutes(Treated with local application of tranexamic acid), recurrent nosebleeds, high score for ISTH and BAT assessments. Decrease in VWF:Ag ratio, VWF:CB ratio decreased, VWF: GPIbR ratio decreased

Family: Maternal grandfather possibly haemophiliac, mother asymptomatic

YEs Kauffman will fund a company that is NOT a not for profit if its terms of assocaition say it has a charitable function. 501c3 for kauffman is all about TAX ANd yes, we can set up an LLC with an FSC bye laws just as easily

For Adjacent Knowledge

We have been introduced to Stuart Kauffman's work on The Adjacent Possible which feels related

https://www.ted.com/talks/stuart_kauffman_the_adjacent_possible_and_how_it_explains_human_innovation?utm_campaign=tedspread&utm_medium=referral&utm_source=tedcomshare

for - AI - futures - two possible directions - dystopian or not - Yuval Noah Harari

for earth system boundary - biodiversity - human modified ecosystems - only local translation is possible

If you put in all physics data up to 1904, would an AI ever be able to have come up with anything from Einstein's annus mirabilis? I suspect not, at least right now.

for - AI - consciousness - not possible - Frederico Faggin

maybe it is k_x x as it is clearly corrected on the next equation.

guidelines to consider

for - adjacency - appendix - evolutionary mystery - possible explanation - metaphor - dead projects

adjacency - between - appendix - evolutionary mystery - possible explanation - metaphor - dead projects - adjacency relationship - Scientists have no good explanation for the function of the appendix - Perhaps it is evolution has bodily artefacts - that are remnants of evolutionary deadends - which once served a purpose for a particular environmental context - but the context changed and the body part remained, not being harmful nor advantagous - much like when we work on projects that don't reach their conclusion and stop - and have many artefacts that still exist such as documents, files, images, mp4, meeting notes, patent filings, built prototypes, etc but are frozen in time

for - SRG complexity mapping - possible candidate

for - dream research

Summary - This presents a new theory of dreams that challenge Freud and Jung's interpretation of dreams. - It is intriguing, as it posits that the dream state is the default state of the brain. - it makes more sense to me.

source - google search - does dreaming allow cognitive during waking state to be possible?

• https://dreams.ucsc.edu/Library/domhoff_2010a.html

interesting how she still felt the need to lean into "maternal" stereotypes in order to run? possible discussion question: whether or not women are truly in power if they're still seen as mother figures?

not an unreasonable worry! especially in the 1970s, male prevalence/power was much higher--- women were only barely able (if even?) to get credit cards.

• for: definition - the adjacent possible

• definition: the Adjacent possible

  • Inn complexity science, the boundary between between the real and the possible

Is it possible that in this paper we'll see the beginning of a shift from Adam Smith's "invisible hand" (of Divine Providence, or God) to a somewhat more scientifically based mechanism based on information theory?

Could communication described here be similar to that of a fungal colony seeking out food across gradients? It's based in statistical mechanics of exploring a space, but looks like divine providence or even magic to those lacking the mechanism?

• for: different possible socio-economic-political futures

• comment

  • Michel outlines the possibilities then selects the last one as the one he situates himself in and will write on, namelyl:
    • A dream to integrate:
      • markets,
      • networks,
      • state functions, AND what we could call
      • ‘the Commons’

Some may not realize it yet, but the shift in technology represented by ChatGPT is just another small evolution in the chain of predictive text with the realms of information theory and corpus linguistics.

Claude Shannon's work along with Warren Weaver's introduction in The Mathematical Theory of Communication (1948), shows some of the predictive structure of written communication. This is potentially better underlined for the non-mathematician in John R. Pierce's book An Introduction to Information Theory: Symbols, Signals and Noise (1961) in which discusses how one can do a basic analysis of written English to discover that "e" is the most prolific letter or to predict which letters are more likely to come after other letters. The mathematical structures have interesting consequences like the fact that crossword puzzles are only possible because of the repetitive nature of the English language or that one can use the editor's notation "TK" (usually meaning facts or date To Come) in writing their papers to make it easy to find missing information prior to publication because the statistical existence of the letter combination T followed by K is exceptionally rare and the only appearances of it in long documents are almost assuredly areas which need to be double checked for data or accuracy.

Cell phone manufacturers took advantage of the lower levels of this mathematical predictability to create T9 predictive text in early mobile phone technology. This functionality is still used in current cell phones to help speed up our texting abilities. The difference between then and now is that almost everyone takes the predictive magic for granted.

As anyone with "fat fingers" can attest, your phone doesn't always type out exactly what you mean which can result in autocorrect mistakes (see: DYAC (Damn You AutoCorrect)) of varying levels of frustration or hilarity. This means that when texting, one needs to carefully double check their work before sending their text or social media posts or risk sending their messages to Grand Master Flash instead of Grandma.

The evolution in technology effected by larger amounts of storage, faster processing speeds, and more text to study means that we've gone beyond the level of predicting a single word or two ahead of what you intend to text, but now we're predicting whole sentences and even paragraphs which make sense within a context. ChatGPT means that one can generate whole sections of text which will likely make some sense.

Sadly, as we know from our T9 experience, this massive jump in predictability doesn't mean that ChatGPT or other predictive artificial intelligence tools are "magically" correct! In fact, quite often they're wrong or will predict nonsense, a phenomenon known as AI hallucination. Just as with T9, we need to take even more time and effort to not only spell check the outputs from the machine, but now we may need to check for the appropriateness of style as well as factual substance!

The bigger near-term problem is one of human understanding and human communication. While the machine may appear to magically communicate (often on our behalf if we're publishing it's words under our names), is it relaying actual meaning? Is the other person reading these words understanding what was meant to have been communicated? Do the words create knowledge? Insight?

We need to recall that Claude Shannon specifically carved semantics and meaning out of the picture in the second paragraph of his seminal paper:

Frequently the messages have meaning; that is they refer to or are correlated according to some system with certain physical or conceptual entities. These semantic aspects of communication are irrelevant to the engineering problem.

So far ChatGPT seems to be accomplishing magic by solving a small part of an engineering problem by being able to explore the adjacent possible. It is far from solving the human semantic problem much less the un-adjacent possibilities (potentially representing wisdom or insight), and we need to take care to be aware of that portion of the unsolved problem. Generative AIs are also just choosing weighted probabilities and spitting out something which is prone to seem possible, but they're not optimizing for which of many potential probabilities is the "best" or the "correct" one. For that, we still need our humanity and faculties for decision making.

Shannon, Claude E. A Mathematical Theory of Communication. Bell System Technical Journal, 1948.

Shannon, Claude E., and Warren Weaver. The Mathematical Theory of Communication. University of Illinois Press, 1949.

Pierce, John Robinson. An Introduction to Information Theory: Symbols, Signals and Noise. Second, Revised. Dover Books on Mathematics. 1961. Reprint, Mineola, N.Y: Dover Publications, Inc., 1980. https://www.amazon.com/Introduction-Information-Theory-Symbols-Mathematics/dp/0486240614.

Shannon, Claude Elwood. “The Bandwagon.” IEEE Transactions on Information Theory 2, no. 1 (March 1956): 3. https://doi.org/10.1109/TIT.1956.1056774.

We may also need to explore The Bandwagon, an early effect which Shannon noticed and commented upon. Everyone seems to be piling on the AI bandwagon right now...

Reply to Bob Doto at https://www.reddit.com/r/Zettelkasten/comments/14ikfsy/comment/jplo3j2/?utm_source=reddit&utm_medium=web2x&context=3 with respect to PZ Compass Points.

I'll agree wholeheartedly that applying methods like this to each note one takes is a "make work" exercise. It's apt to encourage people into the completist trap of turning every note they take into some sort of pristine so-called permanent or evergreen note, and there are already too many of those practitioners, who often give up in a few weeks wondering "where did I go wrong?".

It's useful to know that these methods and tools exist, particularly for younger students, but I would never recommend that one apply them on a daily or even weekly basis. Maybe if one was having trouble with a particular idea or thought and wanted to more exhaustively explore the adjacent space around it, but even here going out for a walk in nature and allowing diffuse thinking to do some of the work is likely to be just as (maybe more?) productive.

It could be the sort of thing to write down in your collection of Oblique Strategies to pull out when you're hitting a wall?

software to rewrite international legal texts relating to human rights, a well written prompt and a few examples, including the FAIR principles will let openAI's chatGPT do it effectively.

Bob Ross' "happy accidents" tied to the idea of serendipity or the outcome of combinatorial creativity within a zettelkasten.

Ross's version is related to experimentation and the idea of adjacent possible. Taking a current known and extending it to see what will happening and accepting the general outcome. This was one of the roots of his creative process.

This creates a blank node and blank nodes make working without a reasoner quite hard. As different triple stores generate different IDs

Demis Hassabis, the founder of DeepMind, classifies creativity in three ways: interpolation, extrapolation, and "true invention". He defines the first two traditionally, but gives a more vague description of the third. What exactly is "true invention"?

How can one invent without any catalyst at all? How can one invent outside of a problem's solution space? outside of the adjacent possible? Does this truly exist? Or doesn't it based on definition.

If the creative process has timeless principles found throughout history, why aren't they written down and practiced religiously withing our culture that is so enamored of creativity and innovation?

As an example of how this isn't true, we've managed to lose our commonplace tradition and haven't really replaced it with anything useful. Even the evolved practice of the zettelkasten has been created and generally discarded (pun intended) without replacement.

How much of our creative process is reliant on simple imitation, which is a basic human trait? It's typically more often that imitation juxtaposed with other experiences which is the crucible of innovation. How often, if ever, is true innovation in an entirely different domain created? By this I mean innovation outside of the adjacent possible domains from which it stems? Are there any examples of this?

Even my own note taking practice is a mélange of broad imitation of what I read combined with the combinatorial juxtaposition of other ideas in an attempt to create new ideas.

"I'd want to learn a lot from Professor Zimmerman so that I may obtain as much information as possible and use it in reality. It's not about the work."

GeneName:DICER1 PMID (PubMed ID): PMCID: PMC6418698 PMID: 30672147 HGNCID: NOT LISTED<br /> Inheritance Pattern: Autosomal Dominant Disease Entity: Cancer; benign and malignant tumors including pleuropulmonary blastoma, cystic nephroma, Sertoli-Leydig cell tumors, multinodular goiter, Thryoid cancer, rhabdomyosarcoma, and pineoblastoma. Mutation: Somatic missense variation Mutation type: missense Zygosity: None stated Variant: unregistered…. Family Information: Characterize germline variants in familial early-onset clorectal cancer patients; The observation of germline DICER1 variation with uterine corpus endometrial carcinoma merits additional investigation. CasePresentingHPOs: uterine and rectal cancers in germline mutation

I can't help but think, what if one used their own collected corpus of ideas based on their ever-growing commonplace book to create a text generator? Then by taking notes, highlighting other work, and doing your own work, you're creating a corpus of material that's imminently interesting to you. This also means that by subsuming text over time in making your own notes, the artificial intelligence will more likely also be using your own prior thought patterns to make something that from an information theoretic standpoint look and sound more like you. It would have your "hand" so to speak.

https://vimeo.com/232545219

from: Eyeo Conference 2017

• http://eyeofestival.com/2017/speaker/robin-sloan/
• https://vimeo.com/channels/eyeo2017/232545219

Description

Robin Sloan at Eyeo 2017 | Writing with the Machine | Language models built with recurrent neural networks are advancing the state of the art on what feels like a weekly basis; off-the-shelf code is capable of astonishing mimicry and composition. What happens, though, when we take those models off the command line and put them into an interactive writing environment? In this talk Robin presents demos of several tools, including one presented here for the first time. He discusses motivations and process, shares some technical tips, proposes a course for the future — and along the way, write at least one short story together with the audience: all of us, and the machine.

Notes

Robin created a corpus using If Magazine and Galaxy Magazine from the Internet Archive and used it as a writing tool. He talks about using a few other models for generating text.

Some of the idea here is reminiscent of the way John McPhee used the 1913 Webster Dictionary for finding words (or le mot juste) for his work, as tangentially suggested in Draft #4 in The New Yorker (2013-04-22)

Cross reference: https://hypothes.is/a/t2a9_pTQEeuNSDf16lq3qw and https://hypothes.is/a/vUG82pTOEeu6Z99lBsrRrg from https://jsomers.net/blog/dictionary

Croatian acapella singing: klapa https://www.youtube.com/watch?v=sciwtWcfdH4

Writing using the adjacent possible.

Corpus building as an art [~37:00]

Forgetting what one trained their model on and then seeing the unexpected come out of it. This is similar to Luhmann's use of the zettelkasten as a serendipitous writing partner.

Open questions

How might we use information theory to do this more easily?

What does a person or machine's "hand" look like in the long term with these tools?

Can we use corpus linguistics in reverse for this?

What sources would you use to train your model?

References:

• Andrej Karpathy. 2015. "The Unreasonable Effectiveness of Recurrent Neural Networks"
• Samuel R. Bowman, Luke Vilnis, Oriol Vinyals, et al. "Generating sentences from a continuous space." 2015. arXiv: 1511.06349
• Stanislau Semeniuta, Aliaksei Severyn, and Erhardt Barth. 2017. "A Hybrid Convolutional Variational Autoencoder for Text generation." arXiv:1702.02390
• Soroush Mehri, et al. 2017. "SampleRNN: An Unconditional End-to-End Neural Audio Generation Model." arXiv:1612.07837 applies neural networks to sound and sound production

73 Cf. Götz Müller, Jean Pauls Exzerpte (Würzburg, 1988), 321–22

I'm not quite sure I understand what the mechanism of this is specifically. Revisit it later. Sounds like it's using the set up the system not only to discover the adjacent possible but the remote improbable.

Really appreciate how you get the idea that rewilding is often about creating some new niche, a new ecology for an existing idea to live in combined with the willing suspension of disbelief that what you are doing is even adjacently possible.

The simplification required to make models and study systems can be a useful tool, but one constantly needs to go back to the actual system to make sure that future predictions and work actually fit the real world system.

Too often social theorists make assumptions which aren't supported in real life and this can be a painfully dangerous practice, especially when those assumptions are built upon in ways that put those theories out on a proverbial creaking limb.

This idea is related to the bias that Charles Mathewes points out about how we treat writers as still living or as if they never lived. see: https://hypothes.is/a/VTU2lFvZEeyiJ2tN76i4sA

Any serious historical or other academic work should include a conversation with the body of other scholarship with which argues for or against.

Comparing and contrasting one idea with another is crucial for any sort of advancement.

.

CDC. (2020, February 11). Coronavirus Disease 2019 (COVID-19). Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/surface-transmission.html

Just because we could make Svelte wrapper components for each Material typography [thing], doesn't mean we should.

Compare:

• material-ui [react] did make wrapper components for typography.

  • But why did they? Is there a technical reason why they couldn't just do what svelte-material-ui did (as in, something technical that Svelte empowers/allows?), or did they just not consider it?

• svelte-material-ui did not.

  • And they were probably wise to not do so. Just reuse the existing work from the Material team so that there's less work for you to keep in sync and less chance of divergence.

Unemployment Paths in a Pandemic Economy. COVID-19 and the Labor Market. (n.d.). IZA – Institute of Labor Economics. Retrieved July 29, 2020, from https://covid-19.iza.org/publications/dp13294/

May be useful as comparison.

Stevens, H. & Muyskens, J. (2020 May 14). See how experts use disease modeling to predict coronavirus cases after states reopen. Washington Post. https://www.washingtonpost.com/graphics/2020/health/disease-modeling-coronavirus-cases-reopening/

problem with transit/possible solution to the problem

Churchill famously said "...democracy is the worst form of Government except for all those other forms that have been tried from time to time..."

Even within this quote it is implicit that there are many others. In some sense he's admitting that we might possibly be at a local maximum but we've just not explored the spaces beyond the adjacent possible.

Ladder safety

Lockout/tagout

Trenching and excavation. Board upheld willful violation.

types of arguments