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  1. Last 7 days
    1. The patient was a boy aged 11 years and 2 months, with chief complaints of blackened skin color on the neck over the past 10 years.
      Case#: Patient_1, male, age 11 years and 2 months at presentation, ethnicity not reported DiseaseAssertion: The patient is asserted by the authors to have SHORT syndrome due to a heterozygous frameshift variant in PIK3R1. FamilyInfo: The patient was adopted. No family history, pedigree information, or parental testing is available. CasePresentingHPOs: HP:0008212 (Acanthosis nigricans), HP:0000834 (Insulin resistance), HP:0000365 (Hearing impairment), HP:0000517 (Elevated intraocular pressure) CaseHPOFreeText: The patient was diagnosed with insulin resistance (HOMA-IR: 14.5) and hyperinsulinemia despite normal glucose tolerance. Ophthalmological examination showed increased intraocular pressure without structural anomalies. Hearing impairment was mild and limited to the left ear. No evidence of short stature or typical craniofacial features. CaseNotHPOs: HP:0004322 (Short stature), HP:0000572 (Deeply set eyes), HP:0009806 (Dental anomalies), HP:0002622 (Joint hypermobility) CaseNotHPOFreeText: Features commonly associated with SHORT syndrome, including short stature, dental anomalies, joint hypermobility, and deeply set eyes, were not observed in this patient. CasePreviousTesting: Whole exome sequencing was performed. Two additional INSR variants were identified and discussed in Supplementary Table S1: - NM_000208.3:c.*104A>G (rs1051690), a benign 3′ UTR variant (homozygous) - NM_000208.3:c.2666G>A (p.Arg889Gln) (rs187282966), a missense variant classified as of uncertain significance. GenotypingMethod: Whole exome sequencing was used to identify the PIK3R1 frameshift variant. No family segregation analysis was performed. PreviouslyPublished: No prior article is known to contain information on the same proband. Variant: NM_181523.3:c.2008delT (p.Cys670ValfsTer3) Zygosity: Heterozygous InheritancePattern: NoInheritanceAssertion MultipleGeneVariants ClinicalStatus: Symptomatic Endocrinopathy:Reported ClinVar: Not found CAID: CA2695204517 gnomAD: Not reported in gnomAD SupplementalData: Yes, additional variants identified by WES are listed in Supplementary Table S1. Ab Deficiencies VCEP

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  2. May 2026
    1. Lewis, Helen. 2026. “The Men Who Want Women to Be Quiet.” The Atlantic 336(6): 26–35. https://www.theatlantic.com/magazine/2026/06/conservative-masculinism-misogyny/686939/ (May 27, 2026; May 28, 2026).

  3. Mar 2026
    1. This finding is consistent with previous work that supports users' sense-making of text, e.g., by modulating text saliency. Specifically, Gu et al. [32] and Gero et al. [29] both found improved reading efficiency and comprehension with saliency-modulating text renderings.

      any single sentence that compares and contrasts this work with prior work.

  4. Jan 2023
    1. Ryan Randall @ryanrandall@hcommons.socialEarnest but still solidifying #pkm take:The ever-rising popularity of personal knowledge management tools indexes the need for liberal arts approaches. Particularly, but not exclusively, in STEM education.When people widely reinvent the concept/practice of commonplace books without building on centuries of prior knowledge (currently institutionalized in fields like library & information studies, English, rhetoric & composition, or media & communication studies), that's not "innovation."Instead, we're seeing some unfortunate combination of lost knowledge, missed opportunities, and capitalism selectively forgetting in order to manufacture a market.

      https://hcommons.social/@ryanrandall/109677171177320098

  5. Aug 2022
    1. Test ways to build earned credentials (certificates, badges, coursework) into degrees; build banks of experience (on-the-job training, internships) that earn credit; admit students simultaneously to two- and four-year institutions; guarantee transfer agreements so students don’t take numerous courses that don’t transfer into a four-year degree; set goals for meaningful employment upon graduation; and work collectively to measure our progress and hold ourselves accountable for the outcome.
  6. Apr 2022
    1. Mike Caulfield. (2021, March 10). One of the drivers of Twitter daily topics is that topics must be participatory to trend, which means one must be able to form a firm opinion on a given subject in the absence of previous knowledge. And, it turns out, this is a bit of a flaw. [Tweet]. @holden. https://twitter.com/holden/status/1369551099489779714

  7. Jun 2021
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  17. Oct 2019
    1. Sancho originally started as a fork of Evergreen but has since evolved to incorporate my favourite ideas from Bootstrap and Material-UI. We make substantial use of Reach-UI where possible to ensure proper accessibility. This project is obviously hugely indebted to all of these projects.
  18. Apr 2016
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  20. Feb 2014