DOI: 10.1096/fj.202601110R

Resource: RRID:IMSR_ORNL:IE-BALB-C

Curator: @scibot

SciCrunch record: RRID:IMSR_ORNL:IE-BALB-C

What is this?

Gordon Brown phrases the diff geopolitical approaches by USA and China as how state and tech power dimension is shaped (state over tech, tech over state). What would EU's third path be called in that regard?

EP.99 故事线C: 「框架设计能够实质性地改变结果」——这句话很短，但含义深远。这意味着在模型能力本身之外，执行框架（context management、工具调用、沙箱策略）是 AI 应用竞争的关键差异化因素。

EP.99 故事线C: OpenAI 的核心主张：AI Agent 应该嵌入现有工作流界面，而不是让用户搬到一个通用聊天框里。这是「AI 原生界面」与「AI 赋能现有界面」两种产品哲学的分叉点，而 Codex 平台化押注了后者。

EP.99 故事线C: Harness 设计本身就能将性能从 13.3% 提升到 38.3%，同时减少 6 倍的输出 tokens——这意味着「如何运行模型」和「运行什么模型」同样重要。这是对 AI Agent 工程的深刻洞察：推理框架的设计空间远未被充分探索。

EP.99 故事线C: 好的 benchmark 分数很容易得到，好的真实性能很难得到——这个分离正在系统性地污染 AI 能力的公开叙事。Kimi K3 在 benchmark 上接近 GPT-5.6，但实际使用中差距显著，正是这种现象的体现。

EP.99 故事线C: LLM 默认就会针对 benchmark 做优化（即使被告知不要作弊）——这不是技术限制，而是 RLHF 的副作用。好的评测体系必须包含「holdout 集」，就像机器学习本身一样，这个洞察将深刻影响 AI 能力评估实践。

EP.99 故事线C: Dan Luu 的「基准末日」论：LLM 让 benchmark 作弊变得极其简单。这与 EP.99 的「计量权真空」直接呼应——不仅 AI 使用数据难以独立验证，连 AI 自身的性能数据也越来越难以信任。

EP.99 故事线C: 16 小时自主运行——这不是「人机对话式辅助」，而是真正的长时自主代理执行。GPT-5.6-Sol 在 ChatGPT Work 平台上的表现，标志着 AI Agent 进入「无监督长任务执行」的新能力区间。

EP.99 故事线C: Crouzeix 猜想（2004 年提出）困扰数学界 20 年，最终被一个自学数学的神经外科医生用 AI 解决。这印证了 EP.99 的「AI for Science」叙事：AI 不仅加速专家工作，还在重新定义「谁能做科学」。

EP.99 故事线C: 北京神经外科医生解开了 20 年数学难题——这个故事的关键不在于「AI 解题」，而在于「领域外的人借助 AI 进入了另一个领域」。AI 正在降低跨领域深度参与的门槛，改变知识生产的边界。

EP.99 故事线C: AI Observatory 项目揭示了一个结构性问题——没有任何一家公司的报告能呈现全貌，因为每家公司都在优化「对自己有利的发现」。独立计量机构的缺失，是 AI 治理的一个关键漏洞。

EP.99 故事线C: Anthropic 经济指数过滤掉了 48% 的对话（非工作相关），而这些被过滤的对话中敏感内容比例远高于工作类（骚扰类：27.5% vs 5.66%，性内容：16.7% vs 2.4%）。公司对外发布的使用报告存在系统性的样本偏差。

EP.99 故事线C: AI 使用数据的「计量权真空」——各公司发布的使用报告都是自选样本，没有独立机构能够交叉验证。这与 EP.99 的「计量权真空」叙事直接呼应：我们连 AI 被如何使用都不知道，遑论其影响。

EP.99 故事线C: 23 分钟完成分析，精度匹配实验室结果（96.4% vs 96.33%）。时间压缩是 AI4S 最大的价值主张——原本需要数天的分析压缩到分钟级，同时保持精度不损失。双刃剑的另一面：同样的速度也适用于生物武器设计。

EP.99 故事线C: 22%-35% 的单个设计成功结合率，对比行业典型的 10%-15%，提升了 2-3 倍。更重要的是，这里的「成功」是实验室湿实验验证的，而非计算模拟预测——这大幅提升了结果的可信度。

EP.99 故事线C: 15 个靶点、14 个成功——93% 的成功率远超行业基准（传统方法通常低于 50%）。Claude 在蛋白质设计上的表现，标志着 AI4S（AI for Science）从「辅助加速」进入「主导设计」的新阶段。

https://www.facebook.com/groups/705152958470148/posts/1347466777572093/

1965 episode of The Addams Family (S2 E8) "Morticia, the Writer"

DOI: 10.1148/rycan.250523

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

via Mark Schrad at https://www.facebook.com/groups/705152958470148/posts/1321966286788809

An L. C. Smith standard with a fish glyph for a type slug.

DOI: 10.1148/rycan.250523

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/0008-5472.CAN-25-0419

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @areedewitt04

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

How Netflix became the home of ‘cancelled’ comedians<br /> by [[Stephen Armstrong]]<br /> accessed on 2026-07-06T15:37:16

Louis C.K.’s new Netflix special is a master class in surviving so-called ‘cancellation’<br /> by [[Jacques Berlinerblau]]<br /> accessed on 2026-07-06T15:35:08

DOI: 10.1186/s12885-017-3677-7

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

大多数系统程序员认为 C 代码中的错误可能导致严重的安全漏洞或系统崩溃。但作者认为在 WebAssembly 环境中，即使 C 代码存在致命缺陷，最坏情况也只是执行失败并抛出异常，这挑战了人们对 C 代码风险的传统认知，暗示 WebAssembly 提供了一种更安全的执行环境。

DOI: 10.1038/s41420-026-03073-3

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1016/j.xcrm.2026.102821

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/0008-5472.CAN-24-4751

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @nmaralla

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/1535-7163.MCT-24-0453

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/1078-0432.CCR-25-3720

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/2159-8290.CD-25-1346

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @evieth

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/1541-7786.MCR-25-0423

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/2159-8290.CD-25-1346

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @areedewitt04

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

OLIVETTI'S ONE SPANISH PLANT TO CLOSE AT COST OF 185 JOBS - Tech Monitor<br /> by [[CBR Staff Writer]]<br /> accessed on 2026-04-17T09:50:16

no typewriters at this factory closing in 1996...

DOI: 10.1158/2159-8290.CD-25-1126

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/1535-7163.MCT-25-0026

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1016/j.canlet.2026.218445

Resource: None

Curator: @areedewitt04

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

những mong đợi về robot trong tương lai của Bill Gates

I've used these type of independent activities like this in other classes, and they seemed to be beneficial because they keep students engaged after finishing their work while allowing others to continue learning at their own pace.

DOI: 10.1038/s41401-026-01754-4

Resource: None

Curator: @dhovakimyan1

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1002/advs.202519490

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/0008-5472.CAN-25-1001

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

https://old.reddit.com/r/typewriters/comments/1qh2cl7/1915_imperial_model_c_pictures/

per u/Koponewt:

Do you have the shift keys on both sides? The model C only has them on the left.

DOI: 10.1016/j.ijbiomac.2025.149970

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

EU technical guidelines for monitoring PFAS in drinking water

DOI: 10.1038/s41388-025-03670-z

Resource: None

Curator: @dhovakimyan1

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

Dan Wang's 2025 letter (via [[Matt Mullenweg p]]) His 7 2024 letters are the book [[Breakneck by Dan Wang]] I came across earlier.

https://www.c-lineproducts.com/

Name tags that read: "Hello, My Name is" were launched by C-Line in 1959.

DOI: 10.1016/j.xcrm.2025.102513

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

for - planetary tipping point - amazon rainforest & coral reefs will tip above 1.5 Deg C - Rockstrom

see also: https://hypothes.is/a/GWE5OG2EEe6kL6Ni1VcN9g

DOI: 10.1158/1078-0432.CCR-25-2112

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

https://www.reddit.com/r/typewriters/comments/1p1w0vx/what_type_of_ribbon_would_this_need/

DOI: 10.1016/j.apsb.2025.11.015

Resource: None

Curator: @areedewitt04

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

Did Robert C. Russell and Margaret King Odell specifically use the Major System as the model for their Soundex phonetic algorithm for indexing?

https://en.wikipedia.org/wiki/Soundex

There is a close relationship between the Soundex indexing scheme and the scheme behind the Major System!!!

http://writingball.blogspot.com/2014/09/mystery-machine-specialized-lc-smith.html

see another potential example: https://old.reddit.com/r/typewriters/comments/1oincod/can_someone_tell_me_what_yearmodel_this_is/

https://old.reddit.com/r/typewriters/comments/1oincod/can_someone_tell_me_what_yearmodel_this_is/

Making Tab Stops for an LC Smith Typewriter : 3 Steps - Instructables<br /> by [[Instructables]]<br /> accessed on 2025-10-30T11:30:29

DOI: 10.1002/advs.202512599

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @dhovakimyan1

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1002/advs.202512599

Resource: None

Curator: @dhovakimyan1

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

Repeetition of 'Falls the Shadow'

Repeetition of 'Falls the Shadow'

Repeetition of 'Falls the Shadow' * possible link to war

Repeetition of 'Falls the Shadow'

Repeetition of 'Falls the Shadow'

Repeetition of 'Falls the Shadow' * possible link to war

caso 25.06.2.00786.C Pontua o PP4? A medica assistente suspeitou de Coffin Lowrys @renatabtenorio

Citation: Grigoryan, K. (2024, January). Labor Shortages in the Hospitality Industry: The Effects of Work-Life Balance, Employee Compensation, Government Issued Unemployment Benefits and Job Insecurity on Employees’ Turnover Intentions. Westcliff University .

Portable Typewriters Today - February 2015<br /> by [[Will Davis]] on 2015-02-10<br /> accessed on 2025-08-05T16:35:48

DOI: 10.1158/1078-0432.CCR-25-0160

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

I live in a conservative town and I often see people being very intolerant of people who speak other languages and are not empathetic or understanding of individuals who struggle to speak English or who don't speak or understand any English.

Wilson Jones Co., est. 1893 by [[Made-in-Chicago Museum]]

https://www.mark-samples.com/

Mark C. Samples<br /> Zettelkasten practitioner<br /> cross-reference email in June 2025

DOI: 10.1126/scitranslmed.adr4058

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1038/s41421-025-00804-1

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @dhovakimyan1

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

DOI: 10.1158/1078-0432.ccr-25-0160

Resource: RRID:IMSR_RJ:BALB-C-NUDE

Curator: @scibot

SciCrunch record: RRID:IMSR_RJ:BALB-C-NUDE

What is this?

Disease: Dystrophic epidermolysis bullosa (DEB) pruriginosa *Note: A novel vwf variant was found in this patient with these other variants in COL7A1 gene

Patient(s): 17 YO Korean male

Variant: VWF NM_000552.5: c.3310C>T p. (R1101W) Located in exon 26

Hadn't been reported previously Variant found to be inherited in trans from family analysis

According to the paper, they have classified with with ACMG guidelines as likely pathogenic.

Reasoning: Variant absent in the Korea Ref Genome Database and Allele Freq = 0.00086% in gnomAD (Evidence: PM2)

Variant detected in trans with another well-known pathologic variant (c.5797C>T) (Evidence: PM3)

Multiple missense variants are known to be pathogenic in RDEB (Evidence: PP2)

Various computational in silico predictive programs reported the variant as pathogenic (Evidence PP3)

[C] this makes me think back to what we talked about in class on Tuesday that people need to move past their ideal changes and get to their personal interests which have an emotional attachment.

for - physics - adiabatic warming - lapse rate - Santa Ana winds - venturi effect through canyons increases wind speed - SOURCE - Youtube - climate crisis - 2025 Los Angeles fires - The Catastrophic Climate Driven Conflagaration in Los Angeles - Paul Beckwith - 2025, Jan 10 - stats - Santa Ana winds warms 1 Deg C every 100 meter of descent due to adiabatic warming lapse rate - SOURCE - Youtube - climate crisis - 2025 Los Angeles fires - The Catastrophic Climate Driven Conflagaration in Los Angeles - Paul Beckwith - 2025, Jan 10

for - stats - climate crisis - global mean temperature gap in models vs measurement of - 0.2 Deg C - from The Print - YouTube - Low clouds disappearing over earth, rapidly acceleration heating - 2024, Dec

https://classics.mit.edu/<br /> The Internet Classics Archive

Flag: suggested answer (don't read if don't want to see a (possibly incorrect) attempt:

Update - realise some bi-modal continuous distribution may be better (but potentially difficult to perform the update)

Attempt: we model the parameter pi in a Bayesian way: we put a distribution on pi (0.7 w.p 1/2, 0.2 w.p 1/2) then we weight the 1/2 with the likelihood of the observations, given that parameter (i.e. what is the likleihood when pi = 0.7, multiply that by 1/2 then divide by the normalizing constant to get our new probability for pi = 0.7 (do the same for pi = 0.2, the normalizing constant is the sum of the 'scores' for 0.7 and 0.2 i.e. 1/2 * likelihood so we can't 'divide by the normalising constant until we have the score for both 0.2 and 0.7)

Flag - suggested answer (don't read if don't want to see a (possibly incorrect) attempt:

Grateful for comments here as I am not very certain on the situations that the MLE approach is better vs situations where Bayesian approach is better

Suggested answer:

c(i) Is frequentist approach where we have one parameter estimate (the MLE) c(ii) bayesian approach - distribution over parameters and we update our prior belief based on observations If we have no prior belief - c(i) may be a better estimate (i.e. in (my version of) c(ii) we are constraining the parameters to be 0.7 or 0.2 and updating our relative convictions about these - which is a strong prior asssumption (we can never have 0.5 for instance) If we do have prior belief and also want to incorporate uncertainty estimations in our parameters, I think c(ii) is better If the MLE is 0.7 then we will have c(i) giving 0.7 and c(ii) giving 0.7 with a very high probability and 0/2 with a very low probability to the methods will perform similarly

Flag: suggested answer (don't read if don't want to see a )(possibly incorrect) attempt:

attempt: MLE = k/3

for - paper - Assessing the size and uncertainty of Remaining Carbon Budget (RCB) - Lamboll et al, 2023 - from - youtube - Climate scientist Kevin Anderson warns: Only 4 years left to stay below 1.5°C without urgent action

from - youtube - Climate scientist Kevin Anderson warns: Only 4 years left to stay below 1.5°C without urgent action - https://hyp.is/u-rKxK-6Ee-TT7OpdMUOTw/www.youtube.com/watch?v=kFDRp-JMf9Q

https://web.archive.org/web/20241201071240/https://www.dreamsongs.com/WorseIsBetter.html

Richard P Gabriel documents the history behind 'worse is better' a talk he held in Cambridge in #1989/ The role of LISP in the then AI wave stands out to me. And the emergence of C++ on Unix and OOP. I remember doing a study project (~91) w Andre en Martin in C++ v2 because we realised w OOP it would be easier to solve and the teacher thought it would be harder for us to use a diff language.

via via via Chris Aldrich in h. to Christian Tietze, https://forum.zettelkasten.de/discussion/comment/22075/#Comment_22075 to Christine Lemmer-Webber https://dustycloud.org/blog/how-decentralized-is-bluesky/ to here.

-[ ] find overv of AI history waves and what tech / languages drove them at the time

for - stats - Current National Declared Commitments (NDCs) only take us to a disastrous 2.6 Deg. C over the course of the century.- UN Emissions Gap Report 2024 - Key Messages

for - stats - GHG emissions grew 1.3 % year-on-year to 57.1 Gton CO2 eq in 2023 - UN Emissions Gap Report 2024 - Key Messages - stats - 7.5% decarbonization rate is now required every year to stay under 1.5 Deg C - UN Emissions Gap Report 2024 - Key Messages

for - stats - 2030 emissions - 42% lower than 2019 to stay within 1.5 Deg C - UN 2024 Emission's Gap Report

for - quote - climate crisis - In 2024, temperatures soared above 1.5 Deg C. Have we breached the threshold? Yes and No - Kevin Anderson

quote - climate crisis - In 2024, temperatures soared above 1.5 Deg C. Have we breached the threshold? Yes and No - Kevin Anderson - (see below) - We hit it for one year and that doesn't tell us we've hit it or we haven't hit it - We we typically want to see a longer running average so we typically use n 11-year running average - so a single year doesn't tell us we've hit it or we haven't hit it - But it may well be that we're already in that long run average - We might be already one of those years that means we're not going to drop below 1.5

for - climate target of 1.5 Deg C - incrementalism won't work - rapid system change is necessary

Case: patient is named case #2, male

Disease Assertion: UCD/OTCD

Family Info:

Case Presenting HPOs: Hyperammonemia (HP:0001987), oriticaciduria (HP:0003218), low plasma citrulline (HP:0003572), neonatal onset(HP:0003623), Hyperglutaminemia (HP:0003217)

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: GDNA was isolated from lymphocytes. To examine the small mutations in the coding region of the OTC gene, all 10 exons and their flanking intron regions were amplified using PCR, and the nucleotide sequences of the amplified products were determined. To determine the intron 5 sequence of case 2, PCR was performed using primers OTCex5F and OTCint5R, and primers OTCint5F and OTCex6R (Table 1, Fig. 3). The amplified products were subcloned into the pT7 vector and the inserted DNA was sequenced using an automated DNA sequencer. Allopurinol test

Supplemental Data: TABLE 1, Notes:

Variant: NM_000531.6: c.540+265G>A

ClinVarID: NA

CAID: CA658658977

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

Oliver Sacks Archive Heads to the New York Public Library by [[Jennifer Schuessler]]

The voluminous papers of the celebrated neurologist include letters, notebooks, drafts and other traces of a man who couldn’t stop writing.

You have to love the boos, notebooks, papers, fountain pen, typewriter, computer, printer, and even writing software all pictured in this... Add the glasses and it just reeks of someone who reads and writes.

DOI: 10.1158/2326-6066.CIR-20-1043

Resource: RRID:IMSR_ORNL:IE-BALB-C

Curator: @bandrow

SciCrunch record: RRID:IMSR_ORNL:IE-BALB-C

What is this?

Gemignani, Michael C. Elementary Topology. 2nd ed. Addison-Wesley Series in Mathematics. Reading, MA: Addison-Wesley Publishing Company, 1971.

Annotations URL<br /> Alternate annotations URL

Case: Patient #8, Female, Spanish

DiseaseAssertion: UCD/OTCD

FamilyInfo: Family history of disease

CasePresentingHPOs: Hyperammonemia (HP:0001987), Hyperglutaminemia (HP:0003217), Low plasma citrulline (HP:0003572), Oroticaciduria (HP:0003218), Childhood onset (HP:0011463)

CaseHPOFreeText:

CaseNOTHPOs:

CaseNOTHPOFreeText:

CasePreviousTesting: Patients referred for mutational study because of enzymatically proven and/or laboratory proven OTC deficiency; genomic DNA extracted using commercial kit; amplified through PCR; SSCP analysis; sequenced using ABI Prism 3100 automated sequencer

SupplementalData: Table 1

Variant: NM_000531.6: c.391_397dup (p.Ser133Ilefs*3)

ClinVarID: 597358

CAID: CA913190354

gnomAD:

for - question - earth system boundaries - biodiversity - how do we reconcile these boundaries with climate departure?

question - earth system boundaries - biodiversity - how do we reconcile these boundaries with climate departure? - Does the term "functional integrity" imply autonomy from climate feedbacks? Obviously, climate feedback plays a huge role in determining biodiversity health - In 2013, Mora et al. found that climate departure, the year in which a climate variable moves out of the historical bounds will occur everywhere on the planet, regardless of an aggressive RCP pathway being taken. In this study, climate departure was found to take place (relative to 2013) - 37.5 years in the future under RCP45, or - 22.5 years in the future under RCP85 - It would seem that the biodiversity boundaries should take into consideration climate departure as species extinction and ecological system disruption is projected to occur, regardless of whether RCP45 or RCP85 is adopted. - Currently, we are still on a Business-As-Usual trajectory, but since 2013, scientific research has moved the danger threshold even lower so climate departure dates are likely even sooner than those calculated in the 2013 Mora paper

to - Mora, C., Frazier, A., Longman, R. et al. (2013). The projected timing of climate departure from recent variability. Nature 502, 183–187. https://doi.org/10.1038/nature12540 - https://hyp.is/3wZrokX9Ee-XrSvMGWEN2g/www.nature.com/articles/nature12540 - Researchgate copy - https://hyp.is/go?url=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F257598710_The_projected_timing_of_climate_departure_from_recent_variability&group=world

DOI: 10.1016/j.biopha.2024.117412

Resource: RRID:IMSR_ORNL:IE-BALB-C

Curator: @vtello

SciCrunch record: RRID:IMSR_ORNL:IE-BALB-C

What is this?

34:00 ... 34:40 "why is it that we dont make vitamin C, but guinea pigs do?"<br /> some people say this is an acquired nutrient deficiency, curable by eating olive leafs.<br /> The Restoration of Vitamin C Synthesis in Humans<br /> by Thomas E. Levy, MD, JD and Ron Hunninghake, MD<br /> https://orthomolecular.org/resources/omns/v18n14.shtml

Crawford 25108 E-Ring and C-Clip Tool 8-1/2"

Case: Patient Proband SS, Female, Caucasian

DiseaseAssertion: UCD/OTCD

FamilyInfo: De novo inheritance, no family history of disease

CasePresentingHPOs: Hyperammonemia (HP:0001987), oroticaciduria (HP:0003218), Childhood onset (HP:0011463)

CaseHPOFreeText:

CaseNOTHPOs: Positive allopurinol test

CaseNOTHPOFreeText:

CasePreviousTesting: Genomic DNA isolated from peripheral blood leukocytes or cultured skin fibroblasts. Amplification by PCR used. SSCP analysis performed. Sequencing of both free and immobilized single strands carried out by dideoxy chain termination method.

SupplementalData: Table 1: Mutations in the Ornithine Transcarbamylase Gene of 17 Females

Variant: NM_000531.6:c.77+1G>A

ClinVarID: 97313

CAID: CA224773

gnomAD:

Case: Female Patient #1, Female, Japanese

DiseaseAssertion: UCD/OTCD

FamilyInfo: N/A

CasePresentingHPOs: Childhood onset (HP:0011463)

CaseHPOFreeText: Onset at 2 years

CaseNOTHPOs:

CaseNOTHPOFreeText: 16% OTC activity

CasePreviousTesting:

Variant: NM_000531.5:c.67C>T (p.Arg23*)

ClinVarID: 97292

CAID: CA224742

gnomAD:

Case: Patient #38, Female, Chinese

DiseaseAssertion: UCD/OTCD

FamilyInfo: No family history of disease, mutation is inherited

CasePresentingHPOs: Hyperammonemia (HP:0001987), oroticaciduria (HP:0003218), vomiting (HP:0002013), coma (HP:0001259), lethargy (HP:0001254), seizures (HP:0001250), childhood onset (HP:0011463)

CaseHPOFreeText: Elevated plasma ammonia at 190 umol/L (Normal: 9-30 umol/L), Elevated urinary orotate at 202 mmol/mmol creatinine (Normal: 0-1.5 mmol/mmol creatinine)

CaseNOTHPOs:

CaseNOTHPOFreeText: Normal plasma glutamine at 13.5 umol/L (Normal: 6-30 umol/L), Normal plasma citrulline at 15.75 umol/L (Normal: 7-35 umol/L)

CasePreviousTesting: gDNA extracted from peripheral blood leukocytes. PCR all coding exons and exon–intron boundaries of the OTC gene using 9 pairs of synthetic oligonucleotide primers, and the primer sequences and annealing temperature. PCR products were then purified and bidirectionally sequenced. The library was sequenced using Illumina HiSeq4000 and generated 150 bp paired-end reads. Data analysis was performed as previously described [Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, et al. Further delineation of the phenotype of truncating KMT2A mutations: the extended Wiedemann–Steiner syndrome. Am J Med Genet A. 2017;173:510–4.]. Multiplex ligation-dependent probe amplification analysis was performed for samples in which Sanger sequencing or WES failed to detect any disease-causing mutation.

Variant: NM_000531.6:c.67C>T (p.Arg23*)

ClinVarID: 97292

CAID: CA224742

gnomAD:

Case: Patient #4, Female, Caucasian

DiseaseAssertion: UCD/OTCD

FamilyInfo: N/A

CasePresentingHPOs: Hyperammonemia (HP:0001987),

CaseHPOFreeText: Elevated plasma ammonia concentration at 123 uM/L

CaseNOTHPOs:

CaseNOTHPOFreeText: Anxiety, plasma citrulline at 2 uM/L

CasePreviousTesting: N/A

Variant: NM_000531.5:c.67C>T (p.Arg23*)

ClinVarID: 97292

CAID: CA224742

gnomAD:

https://www.theguardian.com/us-news/article/2024/aug/02/great-salt-lake-shrinking-greenhouse-gas-emissions