what you're doing basically is reconnecting the striatum that's empowerment with the prefrontal cortex you're reconnecting the motivational engine with a bridge of the ship and that's happening in the brain and uh it has to happen in the mind

how do we help addicts feel empowered rather than disempowered which is a potent antidote to Ego fatigue to feel empowered I can do it okay and I think that we need to help them own other goals

bphen

there's a number of studies that show um I know of two and three of them one about alcohol one of methamphetamine that shows that belief in the disease model itself is a predictor of relapse

conventional rehab programs have very poor success rates usually people relapse anywhere from 2 to 10 times it's you know it's a re revolving door phenomenon

why is it so hard to stop and there's three points

abstinence from from Coke alcohol and heroin you get um you get an increase in gr matter volume in very similar areas

ohnson & Johnson eventually succeeded in getting the DEA to exempt thebaine, a key ingredient in OxyContin, from the 80-20 rule. This change allowed for a significant increase in the importation of CPS-thebaine from Australia, which contributed to the expansion of the opioid supply and the subsequent crisis.

Reagan-era budgets proved so crippling for the FDA that the need for new personnel grew urgent

these changes tend to be less severe if the initial investigator who approved the drug enjoyed long tenure at the FDA.

The FDA's revolving door policy, where officials move from the agency to industry jobs, has created conflicts of interest. A study found that 11 of 16 FDA medical examiners who worked on 28 drug approvals and then left the agency for new jobs are now employed by or consult for the companies they recently regulated.

allowing the pharmaceutical industry to wield significant control over political decisions that affect them.

The expansion of the opioid supply was facilitated by the privatization of poppy fields. The US relies on imports of narcotic raw material, mainly from Turkey and India, to produce legal opioids. Johnson & Johnson, one of the certified importers, sought to change the regulations to allow for more imports from Australia, which would give them a competitive advantage. In the 1990s, Johnson & Johnson lobbied to undermine the "80-20" rule, which stipulated that at least 80% of the narcotic raw material imported into the US had to come from Turkey and India.

failure to require Purdue to demonstrate the efficacy of opioids in treating chronic pain. The agency presumed that the drug was safe and effective based on prior approvals of oxycodone formulations, and the only question was whether the slow-release technology presented a competitive advantage over other similar drugs. The FDA's decision to approve OxyContin has been criticized for its lack of rigor and its failure to consider the long-term risks of opioid use.

The FDA approved the slow-release technology based on this lone citation, which then provided the basis for Purdue's marketing claim that OxyContin presented less of a risk of cultivating opioid dependence.

n the 1950s, the FDA partnered with the pharmaceutical industry, and drug makers benefited from the agency's regime of pre-market approval, which enhanced the prestige of their products. However, the industry also began to criticize the FDA for impinging on individual prerogatives and for being overly bureaucratic. In the 1960s, the Kefauver-Harris Amendments required drug manufacturers to satisfy a more stringent criterion of drug efficacy, leading to complaints from corporate executives about onerous bureaucratic procedures. The deregulation of the FDA gained momentum in the 1980s under President Ronald Reagan, who pursued a systematic approach to deregulation, including editorializing against the agency's authority and depriving it of funds. The Prescription Drug User Fee Act of 1992, supported by President George H.W. Bush and Senator Orrin Hatch, allowed the pharmaceutical industry to pay fees for new drug applications, which went towards hiring new medical examiners and expediting the review process. This act was presented as a way to supply the beleaguered agency with new funds, but it also raised concerns about the industry's influence over the FDA. Under President Bill Clinton, the FDA continued to regard the pharmaceutical industry as "partners, not adversaries," leading to concerns about overprescribing and oversupply. The User Fee Act was initially seen as a success, but it eventually led to the approval of dangerous drugs, highlighting the dangers of the FDA's close relationship with the industry.

Neoliberalism, a conservative philosophy of governance, promoted deregulation and privatization, which enabled the pharmaceutical industry to expand its reach and influence. The FDA and other government agencies failed to regulate the industry effectively, allowing companies like Purdue Pharma to push their products aggressively and ignoring reports of abuse.

Arthur Sackler became a publisher, starting a biweekly newspaper, the Medical Tribune, which eventually reached six hundred thousand physicians. He scoffed at suggestions that there was a conflict of interest between his roles as the head of a pharmaceutical-advertising company and the publisher of a periodical for doctors

rug, hiring Rudolph Giuliani and Bernard Kerik to preempt any government crackdown

The drug's success can be attributed partly to the fact that many doctors wanted to believe in the therapeutic benefits of opioids.

doctors and learned that the "biggest negative" that might prevent widespread use of the drug was ingrained concern regarding the "abuse potential" of opioids. However, some physicians began arguing that American medicine should reexamine this bias,

At present, I don’t have the bandwidth to maintain 2 reference parsers and a spec.

Much later followup-

One of our favorite sayings is: opt in to complexity. We designed Astro to remove as much “required complexity” as possible from the developer experience, especially as you onboard for the first time. You can build a “Hello World” example website in Astro with just HTML and CSS. Then, when you need to build something more powerful, you can incrementally reach for new features and APIs as you go.

Overview

Gene

Functional

Affected Domain

(PubMed:19903818, PubMed:8845167)

Ensembl Gene

dbSNP

genome

Structure

Lost to myself

Slow the transition to clean energy

Toypurina is quoted as saying that she participated in it because she ‘‘was angry with the Padres and the others of the Mission, because they had come to live and establish themselves on her land.’’

Perhaps due to fear or ignorance, or sometimes straight up racism, for as long as Ethnic Studies has existed, there have been efforts to ban, diminish, criticize or censure our programs and curriculum.

#> 1 OpenAlex Only 12427

api_endpoint <- oa_query(
  entity = "works",
  title_and_abstract.search = search_string,
  from_publication_date = from_date,
  to_publication_date = to_date
)

Breakfast Republic in San Diego, California

(a) Failing to detect higher MW ions for PE is an indication of a false positive.(b) Using FTIR with low threshold matches increases the risk of false positives (by the way, FTIR only works on particles >10 µm, not nanoplastics).(c) Using microscopy without chemical confirmation of plastic particles and presenting images of unconfirmed plastics is a misleading application of the method.Altogether, these flaws render their results and conclusions fundamentally incorrect at best.

Dusan (Matt) Materic Thanks Dusan. That makes sense. Would it be feasible/worthwhile, to try to replicate their experiment with these three issues addressed? I assume, given Gauert et al's 2025 paper, the results would still be imperfect, even with their "best" method 3 for minimizing lipid issues, but it seems worth re-testing, as an approximation? Based on their comment in the paper "refinements to the analytical techniques, more complex study designs and much larger cohorts are needed" and their response to a comment on an earlier paper, perhaps they would be game to collaborate?https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfae137/7829158 …more Like Celebrate Support Love Insightful Funny Like Reply Gabriel Enrique De la Torre • 3rd+ Microplastics | Plastic pollution | Antifouling paint particles 1w Dusan (Matt) Materic this pretty much summarizes it

Friedman is correct, for example when he points out the importance of changes like the rise of India or China, the spatial fragmentation of the production process through offshoring or the lowering of transaction costs that makes more and more services tradable.

Substitution

“I’m leaving and I’m never coming back,” I say while putting on my coat. I use my mother’saggrieved, underappreciated tone. The little brown dog transfers her gaze from me to the table, thelast place she remembers seeing toast. The Labrador, who understands English, begins howlingmiserably. She wins the toast sweepstakes and is chewing loudly when I leave, the little dog barkingferociously at her.

To destabilize the current society and accelerate the fall of liberalism, some Silicon Valley protagonists like Peter Thiel finance extreme rightwing media and actors.

Longterminism has its own research institute in Oxford and is financially supported by Thiel, Bezos, Musk and other relevant libertarians.

this is the return of Fascism

Hello there. My name is Louq. Im going to use hypothes.is for my annotations.

Transcranial magnetic stimulation (TMS) is a procedure in which magnetic pulses are applied to the brain of a living person with the goal of temporarily and safely deactivating a small brain region. The p

Activate the H5P plugin

We’ve always advocated that our AI processes are orders of magnitude inefficient.

We believe the bill unduly dictates one particular technical approach, and does so without considering the privacy, security, and equity risks it poses.

M. Chirimuuta

he is the most powerful person in the world himself he is the elite of all Elites so this elitist cabal if there were one he'd be a part of it right and and that's what breaks down their framework If there really were this deep state globalist cabal

The success factors of startups can vary depending on the development stage of the company. As the organization moves into the startup phase, the strategy, core team expertise and diversified knowledge become crucial. Various models have been proposed to understand the factors that contribute to the success of startups at different stages of their development. These models provide insights into the seed startup process, organization creation and exchange with the market [18,60]. It is important to note that the success factors in one phase may not necessarily guarantee success in other phases [67]. Additionally, the choice of financing sources for startups varies depending on their lifecycle stage and financial requirements [50]

elegated

View and Restore Previous Revisions Pressbooks saves the last 10 revisions of any changes you’ve made for each of the three separate stylesheets. You can access these revisions on the Custom Styles page below the save button. To view or restore a previous version of one of your stylesheets: Click the date stamp for the revision you’d like to view to open the Compare Revisions interface for a particular stylesheet Find the revision you’d like to restore from and click the ‘Restore This Revision‘ button

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A single kill by drone, for example, involves anywhere from 100 to 200 people

threat that drone warfare involves hypermasculine killing machines (Masters 2005; Manjikian 2014) or that it entrenches the distinction between “our” space and “their” space (Gregory 2011), either of which would make violence easier

Narrative offers a way to access bodily experiences, such as those of killing with or dying by drones,6 that are otherwise “impossible to reproduce” by those who live them (Wibben 2011, 44)

This can involve studying the experiences of bodies coded as women, gay, or of color in flying drones.

The experience of killing with drones can be both hypermasculine and emasculating, as operators are both invulnerable to physical harm and removed from the traditional masculine ideals of combat.

The technostrategic discourses of drone warfare also distance the use of lethal technology from its deadly consequences, using rational language, euphemism, and abstraction. The altered spatiotemporal experience of drone warfare makes killing easier, but it also raises questions about the masculinity of drone operators. They are often depicted as being in the domestic sphere, juxtaposing their combat experience with running errands for their spouses or coaching a kids' soccer team.

system reflexivity

individual reflexivity is rarely traced through to a collective influence on the broader transdisciplinary research process

this leads to the undermining of every aspect of the nation-state: the welfare state; the power of the legal system; the national economy; the corporatist systems that connected one with the other; and the parliamentary democracy that governed the whole.

New paper! For those of you just starting out in transdisciplinary research, or for those of you that have been doing it a long time and engaging in reflexive practices,

carbohydrate

It makes a lot of sense to have this different strategy of being rooted in the real physical world and have digital nomads being as like a guild of knowledge workers that seed their specialized knowledge because localism is necessary and good, but it's also not necessarily very innovative. Most people at the local level just keep repeating stuff. It's good to have people coming in from the outside and innovating.

role for digital nomads. There's an author called Austin Wade Smith

The web brings that back. It creates an open signaling system where everybody can say, "Oh, I can do that. I want to do that." They're passionate from the beginning. It's meaningful from the beginning

history of labor

Funding the Commons

What's missing, and that's what I try to work on is, because at the same time we have this exponential growth of millions of people doing regenerative local work, but they're underfunded, they're undercapitalized. Usually, it's like two people getting half a wage from an NGO, and they work 16 hours a day. After five years, they totally burn out. How can we fund that? I think that Web3 can be the vehicle for capital to be invested in regeneration.

relative humidity decreases as the temperature increases and uh it often Falls below 10%

the air warms adiabatically which means that it depends on the lapse rate as you as you go to lower and lower altitudes um the temperature increases so the lapse rate is actually the drop of temperature as you get further from the surface of the Earth in dry air the adiabatic lapse rate is n about 10° CS per kilometer or about a degree celsius per uh 100 MERS okay so the as the air is coming down it's warming about 1° cels for each 100 meters of desent

how central Relevance Realisation is. We did arguments around the nature of problem solving.

collaboration

What we do when we go into a sacred setting, is we play with Meta-… We have psycho-technologies - and I'll come back and give a [-] clear definition as we work that out, of a psycho-technology - but we have psycho-technologies that allow us to do this serious play with sacredness so that we are constantly being homed against horror.

to reflect upon, to celebrate and enact Religio is to fundamentally enhance our agency, the disclosure of the world and our connectedness to it. And what else could be more valuable to us? What else could be more valuable to us?

The machinery of Relevance Realization is in that sense, deeply phenomenologically mysterious to me.

NO! You didn't get me because (changes Framing to another Framed and draws another arrow outside the bigger box, connecting to it) what's outside here still is… what is framing that? You cannot have this… You can't have it as a focal object. It is mysterious. It is phenomenologically mysterious. James pointed to this in a wonderful distinction between the I and the Me (I: Me).

Relevance Realization is taking place at a level fundamentally deeper than the level of belief.

it is phenomenologically impossible for me to Perspectively know what it is like to be dead, because whenever I try to conjure up a frame (indicates the smallest, central box in the diagram), “Oh, I'm in a dark room! But wait, I'm still there in the dark room. There's the hereness and the nowness… Oh well, then I'm nowhere! Well, then I'm just an empty…!” No matter what I do, I can't get a framing that has within it my own non-existence, perspectively.

article there called “A Secular Wonder”

book on Wonder (called “Wonder: From Emotion To Spirituality”

the joy of secularism

Religio is… I'm using it in a spiritual sense, [in] the sense of a pre-egoic, ultimately a post-egoic, binding that simultaneously grounds the self and its world.

advances in prompt engineering1, agents2, retrieval-augmented generation (RAG)3, and fine-tuning4

In the 1960s, the use of LSD was seen as a dichotomy between "straights" who did not use illegal drugs and those who got "stoned." However, this dichotomy made it harder to understand why certain substances like tobacco and alcohol were legal, while others like marijuana and LSD were illegal.

making everyone who was stoned a part of an "illegal nation." Government authorities and parents saw illegal drug use as a dangerous practice, and many antidrug advocates made little effort to differentiate between illegal drugs. The criminalization of LSD made its use both more dangerous and more a clear sign of cultural rebellion. Just by using LSD or marijuana, an individual was declaring themselves an opponent of the status quo willing to go to jail in pursuit of a favorite form of altered consciousness.

As a result, underground chemists and dealers took over, and the quality of LSD became unreliable. The US government also began to crack down on LSD use, holding congressional hearings and eventually making it illegal in 1966.

The marijuana trade expanded with new entrepreneurs, including border smugglers and those in hippie tourist resorts. These groups capitalized on their existing networks and skills, such as bilingual abilities and connections with mountain growers.

Mexico became a popular destination for tourists, who would travel to the country to experiment with drugs, including marijuan

The demand for marijuana was fueled by the counterculture movement, with young Americans seeking to rebel against traditional values.

The media played a significant role in shaping public perception by emphasizing the dangers of drugs, affecting both public and medical views on LSD and its users. Psychedelic experts, who also used the drug, faced a dilemma between their professional roles and political pressures. By the late 1960s, the credibility of psychedelic psychiatry was questioned, and therapists were seen as unqualified to address LSD abuse.

In the 1960s, a moral panic emerged as politicized youth were seen as promoting immorality, creating tension between generations.

The media's portrayal of LSD as a symbol of an emergent youth counterculture further exacerbated fears about the drug's impact on society. Medical experts, such as Osmond and Hoffer, criticized the media's sensationalism

public panic about acid made establishing research laboratories for testing underground drugs politically unpalatable.

between Leary's promotion of LSD and his criminal behavior forged a strong illustrative bond between the two activities.

omplained that Leary's promotion of LSD as a recreational drug undermined its potential clinical use.

“But to cook, you must kill. You make ghosts. You cook to make ghosts. Spirits that live on in every ingredient,” -The Hundred-Foot Journey. Hassan, the chef and main character of the movie, learns this from his mother while she's teaching him to cook.

Are we not doing the same now, appearing astounded that a bunch of oligarchs are going through the same revolving doors connecting Big Business and government?

For a few crumbs off their table, that they ploughed into the Trump campaign, the Big Tech brotherhood are in the process of receiving three amazing gifts

the deal they cut with Donald Trump is an incredible bargain with a rate of return that no conventional business can hope to emulate. For a few hundred million dollars that they invested in Trump’s re-election, within minutes of his victory they amassed extra wealth to the tune of hundreds of billions. To be precise, the value of Thiel’s Palantir shot up by 23% while Musk’s Tesla saw its stock rise by 40% to a capitalisation level higher than most of the rest of the global car industry combined.

Aneurin Bevan

How does wealth manage to persuade poverty to use its political freedom to keep wealth in power?

unless we can use our capacities for thought in an arena of rational discourse there's no hope of closing the dread Gap in time to savor ourselves

Institute of Phenomenological-Existential Psychology