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  1. Jun 2024
  2. elifesciences.org elifesciences.org
    The Natural History of Model Organisms: The secret lives of Drosophila flies
    6
    4. Nathan_P 27 Jun 2024
      Another product of anthropogenic change is the evolution of pesticide resistance in a wide range of insects of economic and medical importance.

      can this be used to reflect people's natural resistance to certain diseases?

    5. Nathan_P 27 Jun 2024
      What role can natural history play in our ability to understand these interactions with a view towards disease mitigation and treatment? In the past few decades, the importance of the gut microbiome for models of human health has grown.

      kinda surprising that they could use something as small as these flies to study gut microbes, I wonder what type of tools they use to study this.

    6. Nathan_P 27 Jun 2024
      It is not clear why or how he came to breed them, but their short generation time and ease of rearing were probably very appealing attributes.

      When it comes to model organisms, a short generation time is essential that way we can quickly see the results of potential crosses, another model organism that has a short generation time is the zebrafish

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    elifesciences.org/articles/06793
  3. elifesciences.org elifesciences.org
    Dynamics of venom composition across a complex life cycle
    7
    1. Nathan_P 26 Jun 2024
      ematostella vectensis suggests that venom is already expressed in eggs and larvae of this species.

      an example that this venom was not originally in the animal but was developed over a long period of time

    3. isabellamaisonette 26 Jun 2024
      by ectodermal gland cells

      This relates to gbonet's comment on spiders and the Cnidaria's evolutionary similarities. In an article I read, it pointed out that the epithelia of three major salivary glands may be of ectodermal origin, and spiders deliver venom from modified salivary glands.

    4. isabellamaisonette 26 Jun 2024
      A planula larva emerges from the egg package 48–72 hpf and starts swimming in the water

      I am a bit excited that I predicted this information after researching a bit of the first few sentences!

    5. isabellamaisonette 26 Jun 2024
      They then become swimming larvae, barely visible to the naked eye, that do not feed

      This interested me and I was wondering if these would be considered planula larvae? If so it is extremely interesting and I wonder when their mouth and digestive tract develop. I also learned a new term-- lecithotrophy. Which means that they feed on egg yolk and materials put in the egg by the mother (I would assume the ladder is not applicable since the sea anemones shoot out their sperm and eggs to reproduce there is not time for preparation of greater material).

    6. gbonet 25 Jun 2024
      The oldest extant group of venomous animals is the marine phylum Cnidaria, which includes sea anemones, corals, jellyfish and hydroids.

      I wonder when comparing the evolutionary tree of a Cnidaria species to the evolutionary tree of a snake, or spider, how similar would they be?

    7. gbonet 25 Jun 2024
      The starlet sea anemone, Nematostella vectensis, is becoming a leading cnidarian lab model as unlike many other cnidarian species it can be grown in the lab throughout its life cycle. This makes Nematostella a unique system to study the venom of an animal with a complex life cycle. Another advantage is that the high genetic homogeneity of the common Nematostella lab strain minimizes individual genetic variation, which is far from trivial in most other venomous animals collected from the wild in limited numbers.

      These are all valid reasons that support the claim that the Starlet Sea Anemone is a prime model organism for studying the venom of an animal with a complex life cycle.

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    elifesciences.org/articles/35014
  4. May 2024
  5. elifesciences.org elifesciences.org
    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
    2
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    elifesciences.org/reviewed-preprints/86727v2
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    CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
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    elifesciences.org/reviewed-preprints/90648v2
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    Experience shapes chandelier cell function and structure in the visual cortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC10963032/
  8. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    46
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    elifesciences.org/articles/90683
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    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
    21
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    elifesciences.org/reviewed-preprints/92673
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    Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function
    10
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    elifesciences.org/articles/89424
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    Partitioning to ordered membrane domains regulates the kinetics of secretory traffic
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    elifesciences.org/reviewed-preprints/89306
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    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
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    elifesciences.org/reviewed-preprints/84875
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    Mono-methylated histones control PARP-1 in chromatin and transcription
    1
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    elifesciences.org/articles/91482
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    The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11065425/
  15. Apr 2024
  16. elifesciences.org elifesciences.org
    Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
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    elifesciences.org/reviewed-preprints/94917
  17. elifesciences.org elifesciences.org
    Convergent epigenetic evolution drives relapse in acute myeloid leukemia
    1
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    elifesciences.org/articles/93019
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    Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus
    7
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    ncbi.nlm.nih.gov/pmc/articles/PMC11003744/
  19. Mar 2024
  20. elifesciences.org elifesciences.org
    Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex
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    elifesciences.org/articles/82952
  21. elifesciences.org elifesciences.org
    Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS
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    elifesciences.org/articles/83725
  22. elifesciences.org elifesciences.org
    Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS
    5
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    elifesciences.org/articles/87592
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    Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model
    42
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    elifesciences.org/articles/89453
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    Experience shapes chandelier cell function and structure in the visual cortex
    4
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    ncbi.nlm.nih.gov/pmc/articles/PMC10963032/
  25. elifesciences.org elifesciences.org
    Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2
    20
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    elifesciences.org/articles/84382
  26. elifesciences.org elifesciences.org
    Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy
    10
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    elifesciences.org/reviewed-preprints/95397