10,000 Matching Annotations
  1. Jun 2022
  2. elifesciences.org elifesciences.org
    Drosophila gustatory projections are segregated by taste modality and connectivity
    18
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/78110
  3. elifesciences.org elifesciences.org
    Quantitative mapping of human hair greying and reversal in relation to life stress
    1
    1. chrisaldrich 01 Jun 2022
      Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Molecularly, grey hairs upregulate proteins related to energy metabolism, mitochondria, and antioxidant defenses. Combining HPP profiling and proteomics on single hairs, we also report hair greying and reversal that can occur in parallel with psychological stressors. To generalize these observations, we develop a computational simulation, which suggests a threshold-based mechanism for the temporary reversibility of greying.

      https://elifesciences.org/articles/67437

      Researchers have shown that some types of greying hair are reversible.

      grey hair
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/67437
  4. May 2022
  5. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis
    5
    Visit annotations in context

    Tags

    Annotators

    URL

    pubmed.ncbi.nlm.nih.gov/35522214/
  6. elifesciences.org elifesciences.org
    Working with Bio-protocol to publish peer-reviewed protocols
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/inside-elife/ab137ad4/working-with-bio-protocol-to-publish-peer-reviewed-protocols
  7. Apr 2022
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An auxin-inducible, GAL4-compatible, gene expression system for Drosophila
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC8975555/
  9. elifesciences.org elifesciences.org
    VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/55130
  10. elifesciences.org elifesciences.org
    SpikeInterface, a unified framework for spike sorting
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/61834
  11. elifesciences.org elifesciences.org
    Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/68802
  12. elifesciences.org elifesciences.org
    Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/73520
  13. Mar 2022
  14. elifesciences.org elifesciences.org
    A robust and tunable mitotic oscillator in artificial cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/33549
  15. Feb 2022
  16. elifesciences.org elifesciences.org
    The human coronavirus HCoV-229E S-protein structure and receptor binding
    5
    4. jackiekrauss 21 Feb 2022
      The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V RBDs in complex with human aminopeptidase N (hAPN), as well as the electron cryomicroscopy structure of the 229E S-protein. The structures show that common core interactions define the specificity for hAPN and that the peripheral RBD sequence variation is accommodated by loop plasticity. The results provide insight into immune evasion and the cross-species transmission of 229E and related coronaviruses. We also find that the 229E S-protein can expose a portion of its helical core to solvent. This is undoubtedly facilitated by hydrophilic subunit interfaces that we show are conserved among coronaviruses. These interfaces likely play a role in the S-protein conformational changes associated with membrane fusion.
      ann:summary
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/51230
  17. elifesciences.org elifesciences.org
    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli
    8
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/35224
  18. elifesciences.org elifesciences.org
    Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis
    6
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/02996
  19. Jan 2022
  20. elifesciences.org elifesciences.org
    Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes
    9
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/69584
  21. elifesciences.org elifesciences.org
    Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology
    1
    Visit annotations in context

    Annotators

    URL

    elifesciences.org/articles/67995
  22. elifesciences.org elifesciences.org
    eLife and Medicine: Rigorous review and editorial oversight of clinical preprints
    3
    1. wangtaotao 03 Jan 2022
      Such opportunities and challenges, best illustrated during the pandemic, lie ahead as medicine moves towards the goal of providing evidence-based care to patients no matter where they live. This trajectory also opens up real opportunities for speed, transparency and rich evaluation across peer review in medicine.

      呼吁医学界提供更为快速、透明、评估更为全面的同行评审创造需求

    2. wangtaotao 03 Jan 2022
      But even as the pandemic has demonstrated the potential for rapid, author-driven publication to democratize access and accelerate research, it has exposed the challenges of this model of scholarly communication

      作者驱动的快速出版 面向大众开放 促进研究

    Visit annotations in context

    Annotators

    URL

    elifesciences.org/articles/67528
  23. Dec 2021
  24. elifesciences.org elifesciences.org
    Specialized neurons in the right habenula mediate response to aversive olfactory cues
    9
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/72345
  25. elifesciences.org elifesciences.org
    IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells
    29
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/62432
  26. elifesciences.org elifesciences.org
    Light sets the brain’s daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk
    4
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/70137
  27. homandev.pressbooks.network homandev.pressbooks.network
    Webinar Report: Being a scientist and a parent
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    homandev.pressbooks.network/emptybook/
  28. Nov 2021
  29. elifesciences.org elifesciences.org
    Research Culture: Creating SPACE to evolve academic assessment
    6
    1. dasaptaerwin 10 Nov 2021
      it is designed to help institutional leaders reflect on the extent to which their organization can support sustained and values-driven assessment practices, and where they might focus efforts to further evolve them.

      SPACE to support sustained and values-driven assessment practices.

      research culture
    5. dasaptaerwin 10 Nov 2021
      Rather, it is due to a growing reliance on proxy measures of research quality in the management of recruitment, promotion, tenure and funding decisions: these proxy measures are widely used because they are convenient, not because they are meaningful. The pursuit of a higher ranking in league tables for universities has also contributed to the problem.

      proxy measures >> convenient but not meaningful

      research culture proxy
    6. dasaptaerwin 10 Nov 2021
      Ghent University in Belgium made headlines in 2019 when it announced a new policy for evaluating faculty that marked a shift away from the 'rat race' of metrics and rankings towards more holistic processes focused on valuing and nurturing talent

      notice >> rat race

      research culture
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/70929
  30. Sep 2021
  31. elifesciences.org elifesciences.org
    Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans
    5
    1. aksmit22 22 Sep 2021
      However, the entire repair process for DSBs is notably more efficient in DR than in other organisms; DR is able to restore hundreds of copies of damaged double strands in an hour

      I guess that answers my last question, but raises another question: what allows the repair process to only be most efficient in DR than other organisms, could there be some other important aspect involved in the mechanism?

    2. aksmit22 22 Sep 2021
      The first binding between drRecO and ssDNA occurs in the drSSB-free space of ssDNA and generates a heterotrimer of the drSSB-ssDNA-drRecO complex as an intermediate state. The second binding between drRecO and ssDNA induces the dissociation of drSSB from ssDNA by facilitating a conformational change in ssDNA.

      So ultimately from these findings there are two steps involved in a conformational change in the ssDNA and can avoid using ATP?

    3. aksmit22 22 Sep 2021
      molecular mechanism of D. radiodurans (DR) RecO (drRecO) in SSB displacement from ssDNA at the single-molecule level. DR is the toughest bacterium known, with outstanding resistance to ionizing radiation and DNA damage-inducing reagents (Blasius et al., 2008; Cox and Battista, 2005; Slade and Radman, 2011), which are the main causes of DSBs, a form of fatal biological damage at the genomic level

      I wonder if a section of the genome that helps encode for this mechanism and trait for resistance to ionizing radiation can be inserted in other organisms or be used to prevent DNA damage from radiation

    4. wcmarx 21 Sep 2021
      In summary, our results demonstrate that drRecO binds to ssDNA sequentially using its two binding sites, which gives drRecO the ability to displace drSSB from ssDNA even though the binding affinity of drRecO for ssDNA is two orders of magnitude smaller than that of drSSB.

      It is amazing that cells are capable of performing actions like this and the researchers were able to show this through their results. I would usually assume that a molecule would need a stronger binding affinity to displace another bound protein, so it was interesting to learn how DrRecO can accomplish this with a much lower binding affinity.

    5. tkduncan 21 Sep 2021
      RecO is believed to play a key role in this step because RecO is able to interact with SSB, ssDNA, and dsDNA simultaneously

      So (if I'm interpreting this correctly) RecO is thought to be involved in helping to recruit the rest of the RecFOR machinery to the site of the break because it can interact with SSB, ssDNA, and dsDNA even though SSB binds strongly to ssDNA, right?

    Visit annotations in context

    Annotators

    URL

    elifesciences.org/articles/50945
  32. Aug 2021
  33. elifesciences.org elifesciences.org
    Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/70564
  34. elifesciences.org elifesciences.org
    The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules
    14
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/67294
  35. elifesciences.org elifesciences.org
    An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites
    6
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/68268
  36. elifesciences.org elifesciences.org
    HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways
    44
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/64148
  37. elifesciences.org elifesciences.org
    miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging
    7
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/66768
  38. elifesciences.org elifesciences.org
    VEGF/VEGFR2 signaling regulates hippocampal axon branching during development
    6
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/49818
  39. elifesciences.org elifesciences.org
    Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/50256
  40. elifesciences.org elifesciences.org
    A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in brain neurons
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/48750
  41. elifesciences.org elifesciences.org
    Taste bud formation depends on taste nerves
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/49226