for - adjacency - magic wand -;gene therapy - personalized medicine

for - problem with gene therapy - Very little association between genes and disease - very complex associations

for - adjacency - ecological crisis - gene centrism

adjacency - between - ecological crisis - gene centrism - adjacency relationship - The ecological crisis and climate crisis is a symptom of separation and alienation of humans from nature - Scientific paradigms that take away human agency and minimise it, treating it as secondary reinforced this lack of agency

for - Denis Noble - Ready Noble - evolutionary biology - critique of Richard Dawkins Selfish Gene theory - critique of gene centrism - book - Understanding Living Systems - human agency

summary - In this informative interview, brothers Denis and Ray Noble discuss their new book - Understanding Living Systems, and - dispel the 70 year old narrative of Gene centrism and the selfish gene as determining the high level behaviour of living organisms

for - quote - 70 years of evolutionary biology has to be undone

for - adjacency - Spinoza - Descartes

adjacency - between - Spinoza - Descartes - adjacency relationship - Spinosa was the great enemy of Decartes idea which is that - organisms are mathematically determined from what is in the sperm and the Egg - It is a version 300 years earlier of the central dogma of molecular biology - which has been the disaster that has affected biology ever since

for - quote - genes don't control Richard Dawkins - Ray Noble

for - quote - critique of Richard Dawkins Selfish Gene - Ray Noble

quote - critique of Richard Dawkins Selfish Gene - Ray Noble - (see below)

• they created this mythical world called the gene pole they it's like a fairy tale really

for - quote - the age of reason became unreasonable - Ray Noble

quote - the age of reason became unreasonable - Ray Noble - (see below)

• The Age of Reason became unreasonable
  • in the sense of treating us as machines
• Reason requires openness ,
  • it doesn't require a closed view of life and of humanity

for - metaphor - genes - ghost in that machine

for - quote - human agency - Ray Noble

quote - (see below)

• It had to give us something which all the other organisms didn't have which was
  • a cell that was different
  • a mind that was different
• that gave us agency
  • but denied it to other organisms
  • and that unfortunately I think persisted

for - purpose in nature - exorcism of - Ray Noble - quote - gene centered view - organisms as machines - exorcism - Ray Noble - gene centered view

for - evolutionary biology - purpose in nature Denis Noble - Ray Noble

Interleaving

Interesting. Needs more research on my part.

This is because of the fact that one needs to think (process) before writing. One can't possibly write everything verbatim. Deep processing. Relational thinking.

Lambert, Jonathan. “Why Writing by Hand Beats Typing for Thinking and Learning.” NPR, May 11, 2024, sec. Your Health. https://www.npr.org/sections/health-shots/2024/05/11/1250529661/handwriting-cursive-typing-schools-learning-brain.

YIIIIIKES

This suggests that SIg is buying the heat, which is what makes the whole thing economically workable

This suggests they are just complying with the law now? Or are they going beyond what is required?

how far ahead did they need to forecast before?

Responsabilidad relacional.

En primer lugar, implica respetar la autonomía y dignidad de los individuos cuyas historias están siendo compartidas o representadas en narrativas digitales. Esto significa obtener consentimiento informado y asegurarse de que las personas comprendan cómo se utilizarán sus historias y cómo se presentarán en el entorno digital.

Además, implica una consideración cuidadosa de las posibles repercusiones que pueden tener las narrativas en las personas involucradas, especialmente en términos de privacidad, seguridad y bienestar emocional. Los investigadores y creadores de contenido tienen la responsabilidad de proteger la confidencialidad de la información personal y de evitar cualquier forma de explotación o daño a los participantes.

La responsabilidad relacional también implica un compromiso con la justicia y la equidad en la representación de las voces y experiencias de las personas en el entorno digital. Esto puede implicar dar voz a aquellos que tradicionalmente han sido marginados o subrepresentados en los medios de comunicación y garantizar que se aborden las desigualdades estructurales que pueden influir en quién tiene acceso y quién controla la narrativa.

¿Cuál es nuestra responsabilidad, como investigadores, de facilitar no solamente la expresión creativa, sino más aún el atestiguar esas narrativas como una experiencia de humanización?

Como investigadores, debemos ser conscientes de nuestros propios sesgos y privilegios, y trabajar para no imponer nuestras interpretaciones preconcebidas sobre las narrativas de los participantes. Debemos adoptar una postura reflexiva y crítica que nos permita escuchar y comprender las experiencias de los demás desde sus propias perspectivas culturales, sociales y personales.

Al atestiguar estas narrativas como experiencias de humanización, también debemos buscar formas de utilizar nuestra investigación para abogar por el cambio social y la justicia. Esto puede implicar compartir estas narrativas con audiencias más amplias, incluyendo políticos, responsables de políticas y el público en general, con el objetivo de generar conciencia y promover acciones concretas para abordar las injusticias y desigualdades que se revelan a través de estas historias.

La performance de testimonios como forma potencial de resistencia (narrativa digital) puede ofrecer una manera de expresar y también atestiguar cómo los derechos humanos son negados tras la detención y deportación de inmigrantes.

En este tipo de performance, los individuos pueden compartir sus experiencias de primera mano, narrando los detalles de su situación, las condiciones en las que son detenidos y los abusos que enfrentan durante el proceso de deportación. Al hacerlo, no solo están expresando su propia voz y resistencia, sino que también están arrojando luz sobre las prácticas sistemáticas injustas y violatorias de derechos.

La narrativa digital amplifica aún más el impacto de estos testimonios al permitir que se compartan a través de plataformas en línea, alcanzando audiencias más amplias y facilitando la solidaridad y el apoyo de comunidades globales. Además, el uso de diferentes medios digitales, como videos, fotos, textos y redes sociales, enriquece la experiencia narrativa y hace que sea más convincente y accesible para aquellos que buscan comprender y abogar por un cambio.

.

dev env for PRs

no spin up time

can clone running VMs quickly

fragmentation

dockerfile rootfs

The unwritten details

What if you could open a development environment directly from a @linear ticket? 👀

It's now possible on CodeSandbox! You go to the ticket, click the button, and we create the branch with the right name so you can get started immediately!

Webhook built & runs CodeSandbox 😃

consistent clione and resume

But… can it clone Minecraft?

need to saved only the changed file

only copy data when we need to mutate it

reads from its own block 2

Copy-on-write,

like the name implies,

will only copy data

when we start writing to it.

Our previous mmap example also uses

copy-on-write if MAP_SHARED is not passed.

Getting the clone time down to milliseconds

we'll only have to sync back a little amount!

The kernel does this lazily:

whenever it has a bit of time on its hands,

it will flush the changes back to the file.

as in Emacs of old!

save on bytes to write on disk

Saving snapshots faster

yes

The darker art of cloning memory snapshots

switching branch fresh environment

There's a catch to it as well.

Saving a memory snapshot actually takes a while, which I'll cover in this post.

pause and save memory

4GB

pause the machine

spawns and resumes VMx

The dark art of memory snapshotting

Firecracker to the rescue

The challenge: spinning up a development environment in two seconds

yah

micro VM in 300 milliseconds

required docker would not work

How we clone a running VM in 2 seconds

How we clone a running VM in 2 seconds

x

Der neueste Lancet Countdown in Europe stellt fest, dass Todesfälle in Verbindung mit Hitze in Europa um 9%, in Südeuropa um 11% zugenommen haben. Im Vergleich zum Jahrzehnt 2003-2012 starben im Jahrzehnt bis 2022 auf 100.000 Menschen 17 mehr direkt oder indirekt durch Hitze. Allein im Sommer 2022 gab es ca 60.000 direkt oder indirekt hitzebedingte Todesfälle. https://www.repubblica.it/green-and-blue/2024/05/13/news/the_lancet_cambiamento_climatico_salute-422908978/

Important for installing npm -g whatever

mkdir ~/.npm-global

npm config set-prefix '~/.npm-global'

export PATH=~/.npm-global/bin:$PATH

(Basically add to the path)

source ~/.bashrc

Précédemment, vous avez écrit qu'il n'était pas recommandé d'utiliser le slash dans les balises orphelines afin d'éviter le warning W3C et là vous faites la promotion du slash. Quelle est l'approche à recommander ?

Author response

Reviewer #1 (Public Review):

The authors aimed to investigate if 2-hydroxybutyrate (2HB), a metabolite induced by exercise, influences physiological changes, particularly metabolic alterations post-exercise training. They treated young mice and cultured myoblasts with 2HB, conducted exercise tests, metabolomic profiling, gene expression analysis, and knockdown experiments to understand 2HB's mechanisms. Their findings indicate that 2HB enhances exercise tolerance, boosts branch chain amino acid (BCAA) enzyme gene expression in skeletal muscles, and increases oxidative capacity. They also highlight the role of SIRT4 in these effects. This study establishes 2HB, once considered a waste product, as a regulator of exercise-induced metabolic processes. The study's strength lies in its consistent results across in vitro, in vivo, and ex vivo analyses.

The authors propose a mechanism in which 2HB inhibits BCAA breakdown, raises NAD+/NADH ratio, activates SIRT4, increases ADP ribosylation, and controls gene expression.

However, some questions remain unclear based on these findings:

This study focused on the effects of short-term exercise (1 or 5 bouts of treadmill running) and short-term 2HB treatment (1 or 4 days of treatment). Adaptations to exercise training typically occur progressively over an extended period. It's important to investigate the effects of long-term 2HB treatment and whether extended combined 2HB treatment and exercise training have independent, synergistic, or antagonistic effects.

We agree with the reviewer that investigation of longer-term 2HB treatment may potentially yield interesting findings with more implications to exercise physiology. To investigate the effects of 2HB treatment against or in combination with a progressive exercise training protocol would require an experiment duration between 4 to 12 weeks, based on previous studies (Systematic Review by Massett et al., Frontiers in Physiology, 2021, 10.3389/fphys.2021.782695). However, our experience with these types of experiments is that such a pursuit would require a breadth of work beyond the scope of this current study. For instance, if there were evidence of weakened effect of 2HB over time, one may be compelled to investigate other organs such as the liver to find signs of metabolic adaptation to the exogenous metabolite. If there were additive or synergistic effects on exercise performance, one may be compelled to investigate changes to the cardiovascular system in addition to the skeletal muscle. Additional questions would be raised around the skeletal muscle as well, including assessment of structural and fibre-type changes. Further, these additional mechanisms would need to be characterized in a time course fashion. Rather, we view the scope of the current study to be the acute response to 2HB as an initial report on mechanistic effects of 2HB.

Exercise training leads to significant mitochondrial changes, including increased mitochondrial biogenesis in skeletal muscle. It would be valuable to compare the impact of 2HB treatment on mitochondrial content and oxidative capacity in treated mice to that in exercised mice.

We agree with the author that it is of interest to investigate how 2HB may affect mitochondrial biogenesis. However, our preliminary findings were that 2HB-treated MEFs, C2C12s, and mouse soleus muscles showed no change in PGC1α gene expression after four days of treatment (data not shown). As a follow-up assessment of mitochondrial protein expression, although not specific to mtDNA derived genes, we quantified the expression of the respiratory chain proteins in cells and soleus muscle and found no effect of 2HB treatment (SFig. 5,6). At this stage we conclude that there is not evidence of 2HB modifying mitochondrial biogenesis in this time frame and that further investigation would be best suited to a follow-up study such as one interested in long-term exercise training.

The authors demonstrate that 2-ketobutyrate (2KB) can serve as an oxidative fuel, suggesting a role for the intact BCAA catabolic pathway. However, it's puzzling that the knockout of BCKDHA, a subunit crucial for the second step of BCAA catabolism, did not result in changes in oxidative capacity in cultured myoblasts.

While we report the BCKDH complex to be dispensable for 2KB oxidation it is important to note that previous studies have reported the following: (1) that 2KB is a viable substrate for BCKDH, (2) that 2KB is a viable substrate for pyruvate dehydrogenase, and (3) that pyruvate dehydrogenase is also dispensable for 2KB oxidation (see Steele et al., J Nutr., 114: 701-710, and Paxton et al. Biochem J., 234:295-303). Collectively, these data have led previous studies to conclude that BCKDH and pyruvate dehydrogenase are redundant for the first step of 2KB oxidation, with a preference for BCKDH. The flux through either may depend upon the metabolic environment. The aim for figure 3C was to determine whether the BCAA degradation pathway was required for 2KB oxidation. We conclude that this pathway is required, first at the step of PCC.

While these past studies were mentioned in paragraph 2 of the discussion, in light of the reviewer’s comment we have expanded this paragraph. We have added language to explain that future research interested in the presented 2HB mechanism should carefully consider BCKDH and PDH expression in the cell or tissue of interest, as the metabolism of 2KB is quite central to the presented mechanism.

Nevertheless, this innovative model of metabolic signaling during exercise will serve as a valuable reference for informing future.

Reviewer #2 (Public Review):

Summary:

The manuscript entitled "A 2-HB-mediated feedback loop regulates muscular fatigue" by the Johnson group reports interesting findings with implications for the health benefits of exercise. The authors use a combination of metabolic/biochemical in vivo and in vitro assays to delineate a metabolic route triggered by 2-HB (a relatively stable metabolite induced by exercise in humans and mice) that controls branched-chain amino transferase enzymes and mitochondrial oxidative capacity. Mechanistically, the author shows that 2-HB is a direct inhibitor of BCAT enzymes that in turn control levels of SIRT4 activity and ADp-ribosylation in the nucleus targeting C/EBP transcription factor, affecting BCAA oxidation genes (see Fig 4i in the paper). Overall, these are interesting and novel observations and findings with relevance to human exercise, with the potential implication of using these metabolites to mimic exercise benefits, or conditions or muscular fatigue that occurs in different human chronic diseases including rheumatic diseases or long COVID.

Weaknesses:

There are several experiments/comments that will strengthen the manuscript-

(1) A final model in Figure 6 integrating the exercise/mechanistic findings, expanding on Fig 4i) will clarify the findings.

We appreciate the reviewer’s suggestion to incorporate the exercise findings into a summary figure. However, upon internal review we find that such a figure is too similar to Fig 4i to warrant a new diagram.

(2) In some of the graphs, statistics are missing (e.g Fig 6G).

Some figures are included primarily for the reader to visualize the data while statistical comparison is conducted in a separate figure, for example Fig 2D-G. However, we have revised the figure legends to ensure that statistical comparisons are described for all appropriate figures, including Fig 6G identified by the reviewer.

(3) The conclusions on SIRT4 dependency should be carefully written, as it is likely that this is only one potential mechanism, further validation with mouse models would be necessary.

We appreciate the reviewers feedback and take the point well that a NAD-dependent mechanism will likely stimulate other sirtuins, which are often in fact expressed at greater levels than SIRT4. To reflect this comment in the manuscript we have altered paragraph 5 of the discussion to now focus on sirtuins. We briefly discuss SIRT4 and highlight the need for future consideration of other sirtuins, perhaps particularly mitochondrial sirtuins.

(4) One of the needed experiments to support the oxidative capacity effects that could be done in cultured cells, is the use of radiosotope metabolites including BCCAs to determine the ability to produce CO2. Alternatively or in combination metabolite flux using isotopes would be useful to strengthen the current results.

We appreciate the suggestion from the reviewer and we will look to conduct such an experiment in our follow-up work.

We sincerely thank the reviewers for their input on this study as their suggestions have led to an improved manuscript for the version of record. The reviewer comments are well taken and we are glad that they will be present alongside the final manuscript to provide an important perspective on the work.

helia ipfs

plt.title unterhalb des ersten subplots schreiben, löst das Problem der Überschrift in den unten stehenden Graphen.

Le titre est déjà présent dans le fichier a-propos.html disponible sur Github. Une formulation plus claire serait : créer un titre de niveau 1 dans le corps de la page pour éviter de confondre avec la balise title de l'en-tête.

Description de la balise pas cohérente avec celle du glossaire des balises. Ici, on écrit "Mettre le texte en italique", plus loin comme "important". Dans le glossaire est écrit "Mettre en valeur normale".

anno

obsidian 常用的插件整理 #share

ID as pubsub topic.

Being able to make a disabled person feel independent is an amazing feeling. Most people would look at a disabled person and pity them when in reality there are multiple ways of helping them to feel more engaged and self-sufficient. Helping a disabled person to be more confident is an important factor no one likes to be stared at or talked about when out in public so it is better to find simple solutions to their circumstances. For example when I was had broken my ankle and injured my shoulder they did not automatically give me a helper for a wheelchair and brace for my shoulder. Instead they asked when I was able to due with the current state of my body and what steps I wanted to proceed with due to my pain tolerance. I chose that i wanted a scooter because I would feel more embarrassed if I didn't have the same or equivalent accessibility as other s at my school. So i had a scooter for about 3 months and then moved to crutches and eventually a boot. It felt amazing being bale to walk again and if i hadn't pushed myself i would've probably still been in a wheel chair out of fear that i wouldn't be able to walk again. Thank you to the doctor that supported me with choosing a scooter instead of a wheel chair because it did truly gave me courage to keep improving my mobility.

'A Bicycle of the Mind' - Steve Jobs on the Computer

Steve Jobs, co-founder of Apple, shares some of his insights during a 1990 interview with WGBH.

.

Mediator is a "smart" relay, in that it knows the adressee and can relay with that in mind.

Relay, on the other hand, does not know the destination, it works deterministicly. Iff that relay would always route messages to Bob, then Alice doesn't need to tell anything specific to the relay.

Old School

Back before there were computers there were databases and transactions. Databases were realized as accumulate-only ledgers and transactions were realized with atomically executed contracts.

Datomic’s data and transaction models are highly analogous to these real-world constructs. Datomic accumulates facts (datoms) and, like a ledger, has no addressable places nor semantics for updating thereof.

Datomic’s transactions are like contracts. A contract has a bunch of clauses that, while appearing in order, do not specify a procedure executed in that order. Instead they are a bunch of declarations (of rights, obligations etc) that will all become true together upon execution of the contract (or not at all!), typically by signing of the parties. There is no partial contract along the way - within a contract there is no notion of time or imperative execution, no partial operations on the world etc. Contract execution has no temporal extent - you sign it and it all becomes true.

A contract execution thus identifies a point in time - that point dividing the time before the execution of the contract from the time after, in which the contract (in toto) is in effect. A Datomic transaction does the same.

Obviously, not being a procedure bundling up imperative operations, there is nothing analogous to a traditional DB “stored procedure” in a contract. But Datomic doesn’t offer stored procedures. Instead it has “transaction functions” which, given the state of the db immediately preceding the transaction, calculate values for incorporation within it.

Do contracts have “transaction functions”? Of course they do! Clauses such as “the buyer shall pay the NYSE opening share price on the day of closing + 0.1%” or “the buyer will reimburse the seller for utilities paid for the month of the closing pro-rated by the number of days elapsed as of the closing”, or “the purchaser shall get the contents of the house as of the closing except for the washer/dryer” etc all use a function of the state immediately preceding the moment of execution to calculate values utilized in the contract.

Why do contracts, and Datomic transactions, have such functions? Because they allow you to define transactions that are more flexible as to when they are applied vs contracts/transactions which explicitly supply all values and thus are brittle (and much longer!) and need to be rewritten as the circumstances in which they are to execute change.

That all such clauses/transaction-functions have the immediate past as their (fixed) basis is an essential feature. Having a fixed basis means they can’t be directly composed (i.e. the output of one can’t feed the input of another). In practice that means that there will be only one such clause/function that calculates any particular value, and if it requires compound logic it will be a compound clause, or in the case of a Datomic transaction function, leverage composition in the language (Clojure/Java) in which you write it.

A lot of benefits accrue to Datomic’s “old-school” approach to transactions. I hope the above helps people better understand them.

Rich Hickey https://clojurians.slack.com/archives/C03RZMDSH/p1716049896478429?thread_ts=1716049896.478429&cid=C03RZMDSH

This passage strikes a chord with me, as it brings to light an aspect I had not fully considered before: the potential for discrimination in design. As someone who values human rights and equality, I'm beginning to understand how crucial it is that spaces are designed with more than just aesthetics and functionality in mind. The discussion of marginalization, including discrimination based on race, ethnicity, physical abilities, sexual orientation, or gender expression, underscores a significant oversight in architectural design. It’s a stark reminder that physical and psychological safety are not guaranteed simply by the existence of well-designed spaces. Designers and architects must actively strive to create environments that are genuinely inclusive, considering the varied experiences and needs of all community members.

Test it

• open-ended and
• evolvable,

software that - amplifies our agency.

// by our u mean Human agency.

Perhaps DECENT(ralized) is not enough

Build an Internet as an

• InterPlanetary
• Permanent
• Evergreen
• coevolutionary
• recapitulable
• Autononomous Networks of Human Actors

flip the Web where viertually everything is the dual opposite of what it (c|sh)ould be

We need Human Intelligence Augmentation

more then ever

not just tools for thought but but Networked Improvement Communities engaged in continuous mutual learning

Symmathesys Universalis

and co-creating the very symbiotic machine support needed to boostrap it

!search: The Broken Wheel

• AI,
• decentralized protocols, and
• tools for thought.

will follow

software that amplifies - intelligence, creativity, and - agency, is more real than ever.

AI has unlocked a wild new landscape of possibility.

There is no time to lose.

I’m venturing forward to build something new.

I’ll keep you updated here on the journey

to "Video: 'A Bicycle of the Mind'…" (www.youtube.com) 'A Bicycle of the Mind' - Steve Jobs on the Computer - Steve Jobs, co-founder of Apple, shares some of his insights during a 1990 interview with WGBH.

• the runway too short
• calling the ball

build not - a adecentralized notes graph

but - a personal AI

product market fit

• technical headwinds
• missed market opportunity

to: "GitHub - subconsciousnetwork/n…" (github.com)

• multiplayer
• graph prorocol
• for notes

Fissile materials are materials that can undergo the fission reaction.

Those mostly used in nuclear weapons are highly enriched uranium (U-235 isotope of uranium) and plutonium (Pu-239 isotope of plutonium).

**Mejoramiento: ** El mejoramiento en el contexto anarquista se centra en la creación de una sociedad en la que todas las personas tengan acceso a recursos y oportunidades para vivir una vida digna y satisfactoria, sin privilegios ni exclusiones injustas.

Avance: En el anarquismo, el avance se refiere al movimiento hacia un estado de mayor libertad, justicia y equidad en la sociedad. Esto implica la superación de las estructuras de poder y la ampliación de la autonomía individual y colectiva. El avance anarquista se logra a través de la resistencia activa a las formas de opresión y explotación, así como a través de la construcción de alternativas sociales basadas en la cooperación voluntaria y la solidaridad mutua.

Progreso: En el anarquismo, el progreso se refiere al movimiento hacia una sociedad más libre, igualitaria y justa. Se relaciona con la eliminación de las estructuras de opresión y la creación de relaciones sociales basadas en la autonomía individual, la solidaridad y la cooperación voluntaria. El progreso anarquista implica la emancipación de todas las formas de autoridad y la creación de una sociedad en la que las personas puedan vivir plenamente según sus propios términos, sin coerción ni dominación.

Algunas ideas adicionales que podrían contextualizar esta afirmación:

Explicación mecánica de los fenómenos: Kropotkin sugiere que el anarquismo se basa en una comprensión de la realidad que busca explicar los fenómenos sociales, políticos, económicos y naturales utilizando principios y conceptos que reflejan un enfoque mecánico o materialista. Esto implica ver el mundo como un sistema en el que las relaciones y procesos están determinados por causas y efectos objetivos, en lugar de ser atribuidos a fuerzas sobrenaturales o abstractas.

Rechazo de la arbitrariedad y la autoridad: Kropotkin sugiere que el anarquismo rechaza la arbitrariedad y la autoridad como bases para la organización social. En cambio, aboga por comprender y abordar los problemas sociales y políticos desde una perspectiva racional y basada en la observación empírica.

Materialismo y determinismo: Al reconocer que los fenómenos sociales están determinados por causas materiales y condiciones objetivas, el anarquismo busca identificar y cambiar las estructuras de poder y dominación que perpetúan la opresión y la injusticia.

Visión holística: La frase sugiere que el anarquismo no se limita a ser simplemente una teoría política, sino que constituye una concepción del mundo integral que abarca aspectos sociales, económicos, políticos y filosóficos. Esto implica una comprensión amplia y profunda de la realidad y una búsqueda de transformación social radical en todos los ámbitos de la vida.

Los anarquistas profesionales defienden el derecho de cada individuo a desarrollarse libremente, es decir, a explorar y expresar su identidad, intereses y potencial sin interferencias externas. Esto implica la autonomía individual y el respeto por la diversidad de experiencias y elecciones de vida.

El anarquismo, en su esencia, cuestiona las estructuras de autoridad y poder, promoviendo la autonomía individual y la organización horizontal. En el contexto de la epistemología y la filosofía de la ciencia, se puede apreciar:

Crítica de las estructuras de poder en el conocimiento: En la epistemología, esto se traduce en cuestionar quién tiene el poder para definir qué es el conocimiento válido y quién tiene autoridad para legitimarlo. Esto puede llevar a una mayor apertura a diversas perspectivas y enfoques en la producción y evaluación del conocimiento.

Descentralización del conocimiento: En la filosofía de la ciencia, esto puede implicar una crítica a las estructuras jerárquicas en la investigación científica y una promoción de modelos más horizontales de colaboración y producción de conocimiento. Esto podría llevar a una mayor democratización de la ciencia y a una participación más amplia en el proceso científico.

Énfasis en la autonomía y la experimentación: En la filosofía de la ciencia, esto podría traducirse en un enfoque en la autonomía del científico para explorar nuevas ideas y enfoques, así como en la experimentación con estructuras organizativas alternativas dentro de la comunidad científica.

Desde la perspectiva anarquista, el argumento de que el problema reside en imaginar mundos mejores es considerado un malentendido porque sugiere que la imaginación de un mundo mejor es el problema en sí mismo, cuando en realidad el problema radica en la falta de acción concreta para hacer realidad esos mundos imaginados.

El anarquismo aboga por la acción directa y la transformación social hacia un mundo más justo, igualitario y libre. En lugar de simplemente imaginar utopías sin actuar sobre ellas, el anarquismo propone la construcción activa de alternativas y la lucha contra las estructuras de opresión y dominación existentes.

Este enfoque implica reconocer que la imaginación de un mundo mejor es solo el primer paso. La verdadera tarea consiste en trabajar hacia la realización de esos ideales, desafiando las injusticias y construyendo formas de organización social que reflejen los valores de libertad, igualdad y solidaridad.

Desde la perspectiva anarquista, la teoría social que realmente interesa es aquella que empodera a las personas para que tomen el control de sus propias vidas y construyan comunidades basadas en la libertad, la igualdad y la solidaridad.

Alternate angle at http://images.google.com/hosted/life/81b7b3f24bbe1b3a.html

Nabokov used index cards for his research and writing. In one index card for research on Lolita, he creates a "weight-heigh-age table for girls of school age" to be able to specify Lolita's measurements. He also researched the Colt catalog of 1940 to get gun specifications to make those small points realistic in his writing.

syndication link

Bienvenidos

Revisar a detalle y subrayar dudas. Esto debe quedar bien claro

Revisar a detalle y subrayar dudas. Esto debe quedar bien claro

Revisar a detalle y subrayar dudas. Esto debe quedar bien claro

Revisar a detalle y subrayar dudas. Esto debe quedar bien claro

Those are awful thing to do. These pranks, intended to provoke laughter from viewers, often result in distress and a sense of betrayal among the children, questioning the ethics behind such humor. Similarly, the #MeToo movement employs public shaming to hold sexual harassers accountable, while also fostering solidarity among victims and advocating for broader societal changes.

This article discusses Jennifer Jacquet's perspective on the strategic use of shame as a tool for social change, particularly highlighting its potential for empowering the weak against the strong. Jacquet argues that shame, when wielded effectively, can address injustices and influence powerful entities to alter their behavior. The piece underscores the nuanced view that shame, despite its negative connotations, can be a powerful force for collective accountability and reform.

This shows its potential to emotionally scar children while questioning the societal acceptance of such humor. She argues that the prank, which involves parents pretending to have eaten their children's Halloween candy, can cause genuine distress and trust issues. The article calls for a reevaluation of the ethics behind using children as subjects in practical jokes for entertainment.

I think the Nuremberg Trials served as a significant legal and moral reckoning for the atrocities committed by Nazi leaders, emphasizing the need for accountability and justice. Some, like Hannah Arendt, argued that the magnitude of the Nazis' crimes was so immense that no punishment could truly suffice, reflecting the inherent limitations of human justice in addressing such profound evil. These trials also highlighted the complexities of reconciliation and forgiveness in the aftermath of genocide and mass violence.

Pasadena Claims To Be The Home Of The Cheeseburger — But There’s Beef by [[Hadley Meares]]

DOI: 10.1016/j.celrep.2021.108889

Resource: (Abcam Cat# ab40390, RRID:AB_1141521)

Curator: @Naa003

SciCrunch record: RRID:AB_1141521

What is this?

DOI: 10.1016/j.celrep.2021.108887

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Curator: @Naa003

SciCrunch record: RRID:AB_10597731

What is this?

DOI: 10.21203/rs.3.rs-3950863/v2

Resource: Addgene_50016

Curator: @olekpark

SciCrunch record: RRID:Addgene_50016

What is this?

DOI: 10.21203/rs.3.rs-3950863/v2

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Curator: @olekpark

SciCrunch record: RRID:Addgene_50015

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DOI: 10.1101/2024.03.22.586364

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Curator: @olekpark

SciCrunch record: RRID:Addgene_62197

What is this?

DOI: 10.1101/2024.04.22.590513

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Curator: @olekpark

SciCrunch record: RRID:SCR_002037

What is this?

DOI: 10.1101/2024.04.22.590655

Resource: RRID:Addgene_12253

Curator: @olekpark

SciCrunch record: RRID:Addgene_12253

What is this?

DOI: 10.1101/2024.04.22.590655

Resource: RRID:Addgene_138479

Curator: @olekpark

SciCrunch record: RRID:Addgene_138479

What is this?

DOI: 10.1101/2024.04.22.590634

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Curator: @olekpark

SciCrunch record: RRID:Addgene_139098

What is this?

DOI: 10.1101/2024.04.22.590634

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Curator: @olekpark

SciCrunch record: RRID:Addgene_137725

What is this?

DOI: 10.1101/2024.04.25.591074

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Curator: @olekpark

SciCrunch record: RRID:Addgene_140395

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DOI: 10.1101/2024.04.25.591074

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Curator: @olekpark

SciCrunch record: RRID:Addgene_140371

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DOI: 10.1101/2024.04.24.590935

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Curator: @olekpark

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DOI: 10.1101/2024.04.24.590935

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DOI: 10.1101/2024.04.24.590935

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DOI: 10.1016/j.tranon.2024.101978

Resource: RRID:Addgene_12259

Curator: @olekpark

SciCrunch record: RRID:Addgene_12259

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DOI: 10.1016/j.tranon.2024.101978

Resource: RRID:Addgene_12260

Curator: @olekpark

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DOI: 10.1038/s41467-024-48328-8

Resource: RRID:Addgene_12259

Curator: @olekpark

SciCrunch record: RRID:Addgene_12259

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DOI: 10.1038/s41467-024-48328-8

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1038/s41467-024-48072-z

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Curator: @olekpark

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DOI: 10.1038/s41467-024-48072-z

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Curator: @olekpark

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DOI: 10.1038/s41467-024-48072-z

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SciCrunch record: RRID:Addgene_217831

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DOI: 10.1038/s41467-024-48072-z

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DOI: 10.1038/s41467-024-48072-z

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Curator: @olekpark

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DOI: 10.1038/s41467-024-48072-z

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Curator: @olekpark

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DOI: 10.1038/s41467-024-48072-z

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DOI: 10.1038/s41467-024-48287-0

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Curator: @olekpark

SciCrunch record: RRID:Addgene_27078

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DOI: 10.1038/s41467-024-48287-0

Resource: RRID:Addgene_27080

Curator: @olekpark

SciCrunch record: RRID:Addgene_27080

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DOI: 10.1038/s41419-024-06715-5

Resource: RRID:Addgene_8454

Curator: @olekpark

SciCrunch record: RRID:Addgene_8454

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DOI: 10.1038/s41419-024-06715-5

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1038/s41419-024-06715-5

Resource: RRID:Addgene_89608

Curator: @olekpark

SciCrunch record: RRID:Addgene_89608

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DOI: 10.1093/biomethods/bpae026

Resource: RRID:Addgene_17447

Curator: @olekpark

SciCrunch record: RRID:Addgene_17447

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DOI: 10.1016/j.jbo.2024.100605

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1016/j.jbo.2024.100605

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Curator: @olekpark

SciCrunch record: RRID:Addgene_12259

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DOI: 10.1016/j.jbo.2024.100605

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DOI: 10.1002/ctm2.1678

Resource: RRID:Addgene_12259

Curator: @olekpark

SciCrunch record: RRID:Addgene_12259

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DOI: 10.1002/ctm2.1678

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1002/ctm2.1678

Resource: RRID:Addgene_52961

Curator: @olekpark

SciCrunch record: RRID:Addgene_52961

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DOI: 10.1186/s11658-024-00590-w

Resource: RRID:Addgene_8454

Curator: @olekpark

SciCrunch record: RRID:Addgene_8454

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DOI: 10.1186/s11658-024-00590-w

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1186/s12860-024-00511-x

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1186/s12860-024-00511-x

Resource: RRID:Addgene_12259

Curator: @olekpark

SciCrunch record: RRID:Addgene_12259

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DOI: 10.1186/s13068-024-02516-2

Resource: Addgene_128177

Curator: @olekpark

SciCrunch record: RRID:Addgene_128177

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DOI: 10.1186/s13068-024-02516-2

Resource: RRID:Addgene_128178

Curator: @olekpark

SciCrunch record: RRID:Addgene_128178

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DOI: 10.1038/s41598-024-61626-x

Resource: RRID:Addgene_12259

Curator: @olekpark

SciCrunch record: RRID:Addgene_12259

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DOI: 10.1038/s41598-024-61626-x

Resource: RRID:Addgene_12253

Curator: @olekpark

SciCrunch record: RRID:Addgene_12253

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DOI: 10.1038/s41598-024-61430-7

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1371/journal.pone.0303059

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SciCrunch record: RRID:Addgene_114540

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DOI: 10.1371/journal.pone.0303059

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Curator: @olekpark

SciCrunch record: RRID:Addgene_177474

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DOI: 10.1371/journal.pone.0303059

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SciCrunch record: RRID:Addgene_114544

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DOI: 10.1371/journal.pone.0303059

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SciCrunch record: RRID:Addgene_114536

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DOI: 10.1371/journal.pbio.3002614

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Curator: @olekpark

SciCrunch record: RRID:Addgene_20298

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Curator: @olekpark

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DOI: 10.1038/s41467-024-47516-w

Resource: RRID:Addgene_54528

Curator: @olekpark

SciCrunch record: RRID:Addgene_54528

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DOI: 10.1038/s41467-024-48366-2

Resource: RRID:Addgene_26536

Curator: @olekpark

SciCrunch record: RRID:Addgene_26536

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DOI: 10.1016/j.omtn.2024.102198

Resource: RRID:Addgene_48138

Curator: @olekpark

SciCrunch record: RRID:Addgene_48138

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DOI: 10.1186/s13046-024-03062-3

Resource: RRID:Addgene_12259

Curator: @olekpark

SciCrunch record: RRID:Addgene_12259

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DOI: 10.1186/s13046-024-03062-3

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1186/s13036-024-00430-7

Resource: RRID:Addgene_50832

Curator: @olekpark

SciCrunch record: RRID:Addgene_50832

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DOI: 10.1038/s41420-024-01984-7

Resource: RRID:Addgene_12260

Curator: @olekpark

SciCrunch record: RRID:Addgene_12260

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DOI: 10.1126/sciimmunol.adj7029

Resource: RRID:Addgene_12371

Curator: @olekpark

SciCrunch record: RRID:Addgene_12371

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DOI: 10.1126/sciimmunol.adj7029

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Curator: @olekpark

SciCrunch record: RRID:Addgene_52107

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DOI: 10.1126/sciimmunol.adj7029

Resource: RRID:Addgene_52112

Curator: @olekpark

SciCrunch record: RRID:Addgene_52112

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