3,850 Matching Annotations
  1. Dec 2020
    1. You can create symbolic links using the mklink command in a Command Prompt window as Administrator. To open one, locate the “Command Prompt” shortcut in your Start menu, right-click it, and select “Run as Administrator”.

      Use mklink to create symlinks on Windows

    1. Managing cookies in your browserMost browsers allow you to control how cookies get used as you’re browsing.Some browsers automatically limit or delete cookies. Also, in some browsers, you can set up rules to manage cookies on a site-by-site basis, allowing you to permit cookies only from sites that you trust.In Google Chrome, the Settings contain an option to Clear Browsing Data. You can use this option to delete cookies and other browsing data. See our instructions for managing cookies in Chrome.Google Chrome also supports private browsing with its Incognito mode. You can browse in Incognito mode when you don’t want your site visits or downloads to remain in your browsing and download histories. Once you close all your Incognito browsing windows, Chrome won’t save your browsing history, cookies, and other data.Losing the information stored in cookies may make sites less functional but shouldn’t prevent them from working.
    1. Avoid crowded indoor poorly ventilated environments. Spend more time outdoors. Maintain your distance (more is better but 2 metre is not a panacea). Improve ventilation: open windows/doors. Wear a mask indoors. Wash hands. (27/n) (https://vox.com/science-and-health/2020/5/22/21265180/cdc-coronavirus-surfaces-social-distancing-guidelines-covid-19-risks…)
    2. Prolonged indoor contact in a crowded and poorly ventilated environment increases the risk of transmission substantially. But decreasing occupancy and improving ventilation through opening windows/doors can lower the risk. (11/n)
    3. Prolonged indoor contact in a crowded and poorly ventilated environment increases the risk of transmission substantially. But decreasing occupancy and improving ventilation through opening windows/doors can lower the risk. (11/n)
    1. The men overwhelmed law and order. They pulled down road signs. They smashed windows of the congested streetcars. They toppled telephone booths and lit newspaper kiosks on fire. They heaved bricks from a nearby construction site through the Forum windows. When one young man was arrested and taken into a police car, the protestors began rocking the car, and the police officer feared they would flip it. He told his driver, “When both back wheels touch the ground, gun it!”

      They where mad and I don't blame them

    2. “Because I always try so hard to win and had my troubles in Boston, I was suspended. At playoff time, it hurts not to be in the game with the boys. However, I want to do what is good for the people of Montreal and the team. So that no further harm will be done, I would like to ask everyone to get behind the team and to help the boys win from the Rangers and Detroit. I will take my punishment and come back next year to help the club and younger players to win the Cup.” His words had a palliative effect. The next night nobody threw galoshes, nobody broke any more windows, nobody stopped streetcars.

      It is nice to see that the public listened to the words that he had to say and actually acted on them instead of disregarding them and acting however they wanted.

    1. Montreal went nuts, both French and English, and with Detroit coming in for a St. Patrick's Day game at the Forum, revenge was on some fans' minds. However, nothing may have happened if Campbell hadn't made a tactical error — he showed up to the game (10 minutes late) with his secretary (future wife) and took his regular place. Les Habitants trailed 4-1 at this point as the home side had their minds on something else, and that didn't help matters either. Garbage and various fruit rained down on the NHL boss, one man raced up and smeared a tomato on Campbell, and less than a minute later a homemade tear gas bomb went off. "I have often seen Rocket Richard fill the Forum," said Dick Irvin, Jr., later the legendary Montreal play-by-play and colour man, and at that time the son of the team's coach. "But that's the first time I've ever seen him empty it." Out on the street, the largest riot since Conscription was passed in 1944 (bringing in the draft for the final year of the Second World War) broke out along a seven-block length of Rue Ste. Catherine, featuring overturned cars, smashed windows, a shot fired from somewhere and 137 arrests. CBC Radio Archive: The Richard Riot It went on most of the night with fears of a repeat a few hours later as it grew dark again — only quelled when Richard went on radio and TV, asking for calm. He would reluctantly take his punishment. Since then, larger thinkers on the Quebec scene have argued whether this was the beginning of Quebec's Quiet Revolution — officially pegged for 1960 with the election of Jean Lesage as Premier — or perhaps just the end of a time when hockey was more important than politics, as the latter began to take hold among French Canadian youth

      This says how important to the people of Canada this incident was. Literally both the French and English came together because they were that angry.

    2. Out on the street, the largest riot since Conscription was passed in 1944 (bringing in the draft for the final year of the Second World War) broke out along a seven-block length of Rue Ste. Catherine, featuring overturned cars, smashed windows, a shot fired from somewhere and 137 arrests.

      Taking action was a very strong statement made by the authorities to make arrests.

    3. Maurice Richard, left, played with a fire that made him one of hockey's all-time greats but could also land him in trouble — most dramatically in March of 1955. (The Canadian Press)0 commentsEditor's note: This is part of a series of stories remembering some of Canada's WB_wombat_top sports heroes and moments as the country marks its 150th birthday in 2017. We've also revisited the lives of baseball hall of famer Ferguson Jenkins, speed skater Gaetan Boucher, skier Nancy Greene, figure skater Barbara Ann Scott, distance runner Tom Longboat, Kentucky Derby winner Northern Dancer, sprinter Harry Jerome and auto racing's Villeneuve family. We've also explored Babe Ruth's Canadian origins. Find all of CBC Sports' Canada 150 stories here. Maurice Richard said many times that, in order to understand the events leading up to the riot of March 17, 1955 that forever bears his name, it was crucial to know how violent the National Hockey League was in those days. Sticks were high, fists flew, blood often smeared the ice, and the owners thought this was all manly and a great way to sell tickets. It's also crucial to accept that you cannot really comprehend the Richard Riot unless you lived through and knew: The power of the English seigneurs in Montreal, who many angry French believed to be modern economic descendants of New France's landowners that treated their farmers as serfs before the system was abolished in 1854. How Francophone players in the NHL, almost exclusively the property of the Montreal Canadiens, believed they were more harshly treated by league president Clarence Campbell — especially Richard — when it came time to dish out suspensions and fines. How Richard himself, the Rocket, was so much a part of Quebec society that he transcended even organized religion. Red Storey, a former referee and long-time hockey commentator, once said of him that, in Quebec, "hockey was bigger than the Church, and Rocket Richard was bigger than the Pope." Roch Carrier perhaps explained it best in his famous book The Hockey Sweater. What we can know today are the basic facts. The NHL was a provincial, parochial six-team affair in 1955, featuring barely over 100 players. Many of them hated each other with the type of passion only love can understand, as paleontologist Steven Jay Gould once observed of 1950s New York baseball. Hockey's greatest player at that time was Richard, who in 1945 became the first to score 50 goals in a season (in 50 games, no less). He was a talent so large that Conn Smythe, owner of the Toronto Maple Leafs, offered a million dollars to the Canadiens for him (about $10 million today). Richard's coal-black eyes glowed with defiance, danger and pure disgust for losing. At the Boston Garden on March 13, 1955, bespectacled Bruins defender Hal Laycoe had another of his endless run-ins with Richard, leaving the Habs' star cut on the head after a high stick. A brawl ensued, and the Rocket broke his CCM stick over Laycoe's back. So far, pretty normal for those days. The rest will always be disputed. Conspiracy theories Richard's story had linesman Cliff Thompson holding him back, arms pinned, while Laycoe was allowed to smack away. Rocket said he warned the linesman three times to let him go before he finally clocked the official.  Laycoe's story had Thompson trying to wrestle both of them and, in order to get at the Bruins player, Richard smacked the official. Either way, Maurice Richard was in trouble.  Campbell was already infuriated with the Montreal star, who had a column (Le Tour de Chapeau) ghost written for a French weekly in Montreal that regularly attacked the NHL boss (he was forced to drop it by the league), and No. 9 had already previously walloped a referee. The president really worked for the six owners, five of whom wanted the book thrown at Richard for the Boston incident.  Detroit's Jack Adams knew the road to the Stanley Cup ran that year up St. Catherine Street and, earlier in the season, his forward Ted Lindsay had been dispatched for four games after punching a Toronto fan. Therefore, there was precedent. Conspiracy theories now abound, especially one that says the "hearing" with the players involved a few days later was a sham because the decision had been made. But the fact was the Rocket was suspended for the final three games of the season plus the entire Stanley Cup playoffs.  137 arrests Montreal went nuts, both French and English, and with Detroit coming in for a St. Patrick's Day game at the Forum, revenge was on some fans' minds. However, nothing may have happened if Campbell hadn't made a tactical error — he showed up to the game (10 minutes late) with his secretary (future wife) and took his regular place. Les Habitants trailed 4-1 at this point as the home side had their minds on something else, and that didn't help matters either. Garbage and various fruit rained down on the NHL boss, one man raced up and smeared a tomato on Campbell, and less than a minute later a homemade tear gas bomb went off. "I have often seen Rocket Richard fill the Forum," said Dick Irvin, Jr., later the legendary Montreal play-by-play and colour man, and at that time the son of the team's coach. "But that's the first time I've ever seen him empty it." Out on the street, the largest riot since Conscription was passed in 1944 (bringing in the draft for the final year of the Second World War) broke out along a seven-block length of Rue Ste. Catherine, featuring overturned cars, smashed windows, a shot fired from somewhere and 137 arrests. CBC Radio Archive: The Richard Riot It went on most of the night with fears of a repeat a few hours later as it grew dark again — only quelled when Richard went on radio and TV, asking for calm. He would reluctantly take his punishment. Since then, larger thinkers on the Quebec scene have argued whether this was the beginning of Quebec's Quiet Revolution — officially pegged for 1960 with the election of Jean Lesage as Premier — or perhaps just the end of a time when hockey was more important than politics, as the latter began to take hold among French Canadian youth. Millions of words have been written. Millions more will be. These final words, however, are of the sport.  After the riot, the NHL began to crack down on all-out brawls (especially carrying your stick into one), though it would take another 25 years for the changes to take effect with the institution of the third-man-in rule.  And the Rocket, who always refused to align himself with a political party, would lead his teammates to five straight Stanley Cup victories until retiring in the spring of 1960 with 544 regular-season goals to his credit.  Unbeaten, unbowed, unrepentant — still forever proud. CBC's Journalistic Standards and Practices|About CBC SportsReport Typo or ErrorRelated StoriesCanada 150 Babe Ruth: Made in Canada?Canada 150 The Villeneuves: In the name of the fatherCanada 150 Harry Jerome: Race against timeCanada 150 Northern Dancer: Canadian stallionCanada 150 Tom Longboat: A man called EverythingCanada 150 Barbara Ann Scott: Queen of the iceCanada 150 Nancy Greene: Ahead by a centuryCanada 150 Gaetan Boucher: Memories of SarajevoCanada 150 Ferguson Jenkins: A life of wins and loss

      I find the differences in the hockey uniforms from then until now pretty interesting.

    1. The power of the English seigneurs in Montreal, who many angry French believed to be modern economic descendants of New France's landowners that treated their farmers as serfs before the system was abolished in 1854. How Richard himself, the Rocket, was so much a part of Quebec society that he transcended even organized religion. Hockey's greatest player at that time was Richard, who in 1945 became the first to score 50 goals in a season. At the Boston Garden on March 13, 1955, bespectacled Bruins defender Hal Laycoe had another of his endless run-ins with Richard, leaving the Habs' star cut on the head after a high stick. A brawl ensued, and the Rocket broke his CCM stick over Laycoe's back. Montreal went nuts, both French and English, and with Detroit coming in for a St. Patrick's Day game at the Forum, revenge was on some fans' minds. Catherine, featuring overturned cars, smashed windows, a shot fired from somewhere and 137 arrests. And the Rocket, who always refused to align himself with a political party, would lead his teammates to five straight Stanley Cup victories until retiring in the spring of 1960 with 544 regular-season goals to his credit.

    1.  Soon everything around downstairs was shut and fastened. Janie mounted the stairs with her lamp. The light in her hand was like a spark of sun-stuff washing her face in fire. Her shadow behind fell black and headlong down the stairs. Now, in her room, the place tasted fresh again. The wind through the open windows had broomed out all the fetid feeling of absence and nothingness. She closed in and sat down. Combing road-dust out of her hair. Thinking.

    1. Janie finishes her story, and Pheoby heads off for the evening. So Janie is left alone--to pause, to sit, to reflect. Take a seat beside her. Think back through the novel and consider…

      I chose invitation #19, windows and mirrors, because I felt as if it really represented and could show how Janie really felt, self-reflecting. I think, also, self-reflection is really important for character development in the long-run. Self-reflection can be a way to grow and learn. Janie, for one, had peace and quiet around her, left with only herself and her thoughts to reflect on.

    1. “De lake is comin’!”

      Invitation to Create #14: “De lake is comin’!” Quote: “They saw other people like themselves struggling along. A house down, here and there, frightened cattle. But above all the drive of the wind and the water. And the lake. Under its multiplied roar could be heard a mighty sound of grinding rock and timber and a wail… The monstopolous beast had left his bed. The two hundred miles an hour wind had loosed his chains. He seized hold of his dikes and ran forward until he met the quarters; uprooted them like grass and rushed on after his supposed-to-be conquerors, rolling the dikes, rolling the houses, rolling the people in the houses along with other timbers. The sea was walking the earth with a heavy heel.” (p. 161-2) This is the Link To my Music: https://drive.google.com/file/d/1rYskauluExdaH5ouCYWjuYXqul5LPCXd/view

      This musical composition is written in the Baroque Sonata style which tends to be intense and emotional, some of which I wrote down, and some parts that I improvised to fill in certain gaps. This piece depicts the aftermath of the giant storm which I feel is the most important part of the hurricane, because it is the most distressing time. The sonata starts out with a classic, chromatic, and dramatic bassline which represents the tears of a person who lost their loved ones in the storm. The sound is meant to emulate despair and heaviness of the heart. After the chromatic bassline, I added major double stops which create more complexity and fullness to the music. The reason I chose this piece to transition into a major key is not just to make it more interesting and contrasting, but, also, to emulate a rainbow at the end of the storm which shines over scattered debris and the corpses of dead trees. Then, I go back to the minor key and continue emulating the person’s mourning, up until I reach a few more double stops which are the note G and D. This part of the piece represents the climax, when the person feels the most pain, because the person realizes the devastation of the hurricane. During a hurricane, time is of the essence, as a giant never ending hole which covers part of the earth, like an infection that sickens that specific part of the world. For some people, it is a never ending virus, which destroys everything that the people call home. The waves start small, and get larger and larger, soon claiming the beach. People in its wake start seeing little bits of plywood that reside from the beach shacks that sit on the shore. Boats begin rocking back and forth, back and forth causing the people in the boats to feel queasy. Some people start to go ashore, while others ride it out. The waves get higher to ten feet tall causing a few boats tip over. Sirens begin alarming people to get to safety. The people on the shore see the last air bubbles coming from the boats’ owners who are under water. People scream and run as a twenty foot wave comes toward them. It’s reminiscent of a monster teasing its prey before the monster eats them. As the people run, they search for shelter or anything they can grab onto. Trees begin to fly as people dodge them to protect themselves from shards or other flying objects. Some of the elderly, or those not as physically fit, are at a disadvantage, such as mothers who are weak and carrying children. The mothers give their children to anyone who can take them, so as to make sure they are safe. The ones who cannot make it are swept away by the waves, never to be seen again as they fall off the face of the earth. Now, the winds start blowing cars, propelling them upward far away from whence they came. Houses start to fling, and people are thrown in the air from big gusts of wind. Millions of pieces of debris, from the houses, are flying everywhere. As the winds calm, and the tides go back in, the carnage that has been left behind is visible. The hurricane made some very strange combinations, like cars and buildings smashed together. Wood, tile, and plastic lay on the ground as a sailboat severed into two pieces on the sand. Personal belongings and fragments of peoples lives are scattered lay on the ground for everyone to see. Pictures of families that now have been torn apart, as well as clothes and shoes without owners, are everywhere. One surviving mother sees her child’s baby shoes. Others are praying and thankful to be alive. It’s crazy to think that there are people in the world praying for millions of dollars when some are praying just for their lives. A rainbow appears, as people look up to the sky. Pieces of glass, reflecting on windows and doors, create a paradox of light. One father finds his two children, and they embrace each other. Life goes on.

    2. Invitation to Create #14: “De lake is comin’!” Quote: “They saw other people like themselves struggling along. A house down, here and there, frightened cattle. But above all the drive of the wind and the water. And the lake. Under its multiplied roar could be heard a mighty sound of grinding rock and timber and a wail… The monstopolous beast had left his bed. The two hundred miles an hour wind had loosed his chains. He seized hold of his dikes and ran forward until he met the quarters; uprooted them like grass and rushed on after his supposed-to-be conquerors, rolling the dikes, rolling the houses, rolling the people in the houses along with other timbers. The sea was walking the earth with a heavy heel.” (p. 161-2) This is the Link To my Music: https://drive.google.com/file/d/1rYskauluExdaH5ouCYWjuYXqul5LPCXd/view

      This musical composition is written in the Baroque Sonata style which tends to be intense and emotional, some of which I wrote down, and some parts that I improvised to fill in certain gaps. This piece depicts the aftermath of the giant storm which I feel is the most important part of the hurricane, because it is the most distressing time. The sonata starts out with a classic, chromatic, and dramatic bassline which represents the tears of a person who lost their loved ones in the storm. The sound is meant to emulate despair and heaviness of the heart. After the chromatic bassline, I added major double stops which create more complexity and fullness to the music. The reason I chose this piece to transition into a major key is not just to make it more interesting and contrasting, but, also, to emulate a rainbow at the end of the storm which shines over scattered debris and the corpses of dead trees. Then, I go back to the minor key and continue emulating the person’s mourning, up until I reach a few more double stops which are the note G and D. This part of the piece represents the climax, when the person feels the most pain, because the person realizes the devastation of the hurricane. During a hurricane, time is of the essence, as a giant never ending hole which covers part of the earth, like an infection that sickens that specific part of the world. For some people, it is a never ending virus, which destroys everything that the people call home. The waves start small, and get larger and larger, soon claiming the beach. People in its wake start seeing little bits of plywood that reside from the beach shacks that sit on the shore. Boats begin rocking back and forth, back and forth causing the people in the boats to feel queasy. Some people start to go ashore, while others ride it out. The waves get higher to ten feet tall causing a few boats tip over. Sirens begin alarming people to get to safety. The people on the shore see the last air bubbles coming from the boats’ owners who are under water. People scream and run as a twenty foot wave comes toward them. It’s reminiscent of a monster teasing its prey before the monster eats them. As the people run, they search for shelter or anything they can grab onto. Trees begin to fly as people dodge them to protect themselves from shards or other flying objects. Some of the elderly, or those not as physically fit, are at a disadvantage, such as mothers who are weak and carrying children. The mothers give their children to anyone who can take them, so as to make sure they are safe. The ones who cannot make it are swept away by the waves, never to be seen again as they fall off the face of the earth. Now, the winds start blowing cars, propelling them upward far away from whence they came. Houses start to fling, and people are thrown in the air from big gusts of wind. Millions of pieces of debris, from the houses, are flying everywhere. As the winds calm, and the tides go back in, the carnage that has been left behind is visible. The hurricane made some very strange combinations, like cars and buildings smashed together. Wood, tile, and plastic lay on the ground as a sailboat severed into two pieces on the sand. Personal belongings and fragments of peoples lives are scattered lay on the ground for everyone to see. Pictures of families that now have been torn apart, as well as clothes and shoes without owners, are everywhere. One surviving mother sees her child’s baby shoes. Others are praying and thankful to be alive. It’s crazy to think that there are people in the world praying for millions of dollars when some are praying just for their lives. A rainbow appears, as people look up to the sky. Pieces of glass, reflecting on windows and doors, create a paradox of light. One father finds his two children, and they embrace each other. Life goes on. )](http://insert-your-link-here.com))

    3. The wind came back with triple fury, and put out the light for the last time. They sat in company with the others in other shanties, their eyes straining against crude walls and their souls asking if He meant to measure their puny might against His. They seemed to be staring at the dark, but their eyes were watching God.

      Their Storm

      “The wind came back with triple fury, and put out the light for the last time. They sat in company with the others in other shanties, their eyes straining against crude walls and their souls asking if He meant to measure their puny might against His. They seemed to be staring at the dark, but their eyes were watching God…”

      His is a violent hand, thought Artemis, as the world below her fell under a wash of murky water. The earth trembled beneath Poseidon’s waves, which rippled violently under the frosted shine of Artemis’ moon─her patronage. She frowned, nails digging crescents into the soft flesh of her palms. It looked so cold now, she thought, raped of its tranquility; yet, here she lay, alone at forest's edge, inept to do anything but watch as another town fell wreckage to the Gods’ wrath… Thunder rolled on the darkened horizon, black, all except for the occasional flash of lightning. Zeus’ bolts speared clean through the night, rupturing the fine fabric of space; it frayed open at the wounds, humming with electricity. Then, the sky─the cavernous void that Mortals so often turned to in times of trouble─exploded in a flash of purple light. Artemis gathered the splintered sky in her upturned palms and eyed it curiously. Upon its glazed surface, she found the faces of stricken mortals. Stars mapped the tears traveled down their sunken cheeks. They huddled together in tight spaces, windows rattling against the ferocity of the wind. Their eyes, wild with panic, sought out a savior. Artemis stepped forward. Suddenly, the damp grass beneath her feet gave way to peeling wood, and she found herself face-to-face with those simpering mortals. She tilted her head curiously to the side. Two men and one woman. For a moment, Artemis thought they’d noticed her. She stood firmly in front of the door separating them from the Storm. However, they looked completely past her; their attention belonged to something far in the distance. She grimaced. She’d brought them a God, yet their eyes were watching no one at all. These mortals prayed to false idols. Wasn’t that the reason the Storm was brought upon them? To punish them for their ignorance, their blatant disrespect…! Artemis sought out the anger in her heart─she, the deity who slayed men with arrows, turned deplorables into feral beasts, and traitors into constellations─but, to her surprise, turned up empty. Her anger belonged to no mortal, rather Artemis’ eyes trailed upwards towards the sole bearer of her spite. She flinched with each clap of her father’s hand. His spiteful flames engulfed the surrounding woods. The sound pierced through the wind’s wailing, like an arrow slipped clean through the breast of her bow. It scared all game miles off. “Whut we gointuh do now?” The mortal woman cried out. Artemis turned. The older woman, in spite of her dark complexion, was pale as a sheet, as she stared out into the raging Storm. Her eyes were black as the night yonder. She was shaking, mouth hung slightly ajar. Fear melted the harsh lines from her face. In a moment’s time, she’d regressed ten years, no longer the older, elegant woman of a minute ago but a girl, just shy of seventeen. Artemis found her terror beguiling─almost familiar─and so she stepped forward, hand outreached, as if to comfort the woman. She opened her mouth to speak, but- “We got tuh walk,” the tall man cut in. He swaggered over to the black-eyed woman and took her hand in his own. Artemis’ face fell. She considered disemboweling the mortal for his blatant disregard, but the black-eyed woman begged his pardon with her pitiful expression. “In all dis weather, Tea Cake?” The black-eyed woman asked. “Ah don’t b’lieve Ah could make it out de quarters…” “Oh yeah you kin!” The tall man then proceeded to hurd the woman out of the clutches of shelter and into the Storm. Artemis, begrudgingly, followed suit.

      Through the thick of the fog, a man stood proud, decorated in black velvet robes, with a crown of thorns braided carefully through his graying hair. A long train of men, women, and children formed at the base of his makeshift throne─a capsized tree trunk sunk low into the surrounding marshland. Artemis felt something akin to pity while they congregated. The mortals’ clothes looked completely soaked through, pressed flush against their pale, translucent skin. They could hardly speak through the chattering of their own teeth… She’d bargained that some had attempted to return home. (All looked in need of a hot bath and some fresh clothes.) However, they’d ought to have realized such was impossible now. Slowly, the crowned figure─Hades─led them out of the sunken town. Artemis watched them go: the funeral march. For a moment, the goddess thought she’d pinpointed Tea Cake, the tall, foolish man who’d dared to venture out into that violent Storm, among the deceased. However, she didn’t bother to confirm her suspicions. She simply waited, as Hades and his fallen mortals─drowned, crushed, or swept away─sunk low into the muddied earth. Gone forever. How foolish men were, Artemis thought, as she lay in a patch of drying marshland, the remains of the Storm a blight upon her mind. All of them, bullheaded, like her father. Their precious prides always superseded their desire for self-preservation, their empathy for others… As she waited for daybreak and for Apollo’s fiery chariot to ascend upon the sky, Artemis found her thoughts unconsciously wandering back towards the mortal couple─the black-eyed woman and the tall man, Tea Cake. The way the black-eyed woman had clung to the man, even as they chose to brave the cruelty of her father’s Storm─even as the rapids threatened to pull them both under, damning them to a restless eternity in Hades’ Underworld─made Artemis absolutely certain of one thing: that woman was in love with Tea Cake. Only love, and love alone, could make a woman so foolish as to match wits with a man.

    1. While Tea Cake was standing and looking he saw two men coming towards him with rifles on their shoulders. Two white men, so he thought about what Janie had told him and flexed his knees to run. But in a moment he saw that wouldn’t do him any good. They had already seen him and they were too close to miss him if they shot. Maybe they would pass on by. Maybe when they saw he had money they would realize he was not a tramp.

      I feel bad for Janie and Tea since she's in the house during the hurricane. I'm not saying that it’s her fault for being there because Tea Cake made them stay but it was a really bad idea because the house is fooding and the wind is really loud and bad. The part “The wind through the open windows” really makes it sound like its a really bad storm.

    1. google just delivered true useful and usable digital agency whilst Siri is still in the dark ages, cracking jokes to only iPhone users, Amazon, is still trying to put a sales women (Alexa) in your living room and Cortana… What is Cortana doing again? Besides occasionally telling you the weather (if you happen to be sitting on a windows 10 PC).

      usable digital agency

    1. New York State Legislature’s passage of the new Tenement House Act of 1901.  While this act did not officially ban the construction of tenements on twenty-five-foot-wide lots, it made it difficult to efficiently plan such buildings.  Most new law tenements were built on lots with a width of thirty-five feet or more.  As required by the law, these tenements had larger, if still relatively small light courts and occupied somewhat less of the total lot area.  The new law mandated that all rooms have windows and each apartment have its own toilet facilities.  Another important aspect of the law was its impact on older tenement buildings.  The law mandated a series of changes designed to address the dangerous and unsanitary conditions in these pre-existing tenements.  Changes included improved lighting, banning second windowless interior rooms (a provision later rescinded), and requiring the addition of one toilet for every two families.

      This is when the 1901 legacy was finally passed.

    1. Tons of stories get passed around about it, like a patient who took an axe to every person in the building, or a person who locked all the doors and windows, leaving everyone to “bedlam,” Kleen said.

      The writing of this article isn't super clear. There is no evidence that any of these events happened- people just think that all old asylums are haunted.

    1. Double-clicking on a reference will open the associated file in default PDF viewer (I highly recommend PDF X-Change Editor for Windows users).

      Se propone un visor para los archivos PDF en Windows que se llama PDF X-Change Editor

    1. rom 2010, rotary wing assets became increasingly available to support SOTG operations, anda pattern developed by which there would be alternating four day windows during which rotarywing assets would be available. As a result, a cycle was established of four days planning and targetdevelopment (during which the Force Element remained positioned to conduct vehicle-mountedoperations if necessary), followed by a four day ‘rotary wing period’ (during which operations wereconducted).

      Important.

  2. Nov 2020
    1. The window was open and through it came the distant roaring of the falls. The first mosquitos, of the spring, attracted by the light, entered likewise and the slender music of their wings filled the house. Tit'Bé went and closed the window, then fell on his knees again beside the others.

      This must have been a huge annoyance to the time preiod due to the fact they didnt have windows like we do today.

    1. However, they can neither change the main function, nor delete lines or change theprogram structure. In addition, students are not allowed to open other windows and can only compile or run in the IDE.

      pretty limiting. wondering how this method can be used in a real-world context?

    Annotators

    1. Note: This rebuttal was posted by the corresponding author to Review Commons. Content has not been altered except for formatting.

      Learn more at Review Commons


      Reply to the reviewers

      Reviewer #1 (Evidence, reproducibility and clarity):

      This manuscript follows on from previous work from the Rhind lab to investigate whether the load of MCMs at origins is a factor in when the origin activate (as a population average) during S phase. The authors use budding yeast and a auxin degron system to modulate the levels of an MCM subunit. This allows them to titrate down the concentration of the MCM hexamer and observe the effect. Crucially, they assay both the reduction in MCM load at origins and the subsequent replication dynamics in the same experiment. This is the power of their approach and allows them to rigorously test their hypothesis.

      **Major comments**

      1.I found the introductory paragraph discussing the Rhind lab hypothesis about the possibility of multiple MCM being loaded at origins somewhat misleading. The first paragraph of the discussion was much clear. However, I feel that the introductory paragraph should deal with the difference between the two proposals: 0-1 MCM-DH per origin (de Moura et al), vs 0-50+ MCM-DH (Yang et al). It s also important to note that Foss et al find that "In budding yeast, [MCM] complexes were present in sharp peaks comprised largely of single double-hexamers" - i.e. consistent with 0-1 MCM-DH per origin.

      To improve the balance of the introduction, I think the authors should briefly introduce the concepts behind the 0-1 MCM-DH per origin; this was defined as origin competence by Stillman and clearly described by McCune et al (2008; see figure 8) prior to the work from de Moura et al.

      Furthermore, in the discussion the authors should be more even-handed. To date there is no data to conclusively rule one way or the other in distinguishing between single vs multiple MCMs. The authors cite Lynch et al and state "overexpression of origin-activating factors in S phase causes most all origins to fire early in S phase, consistent with most origins having at least one MCM loaded". However, Lynch et al report equivalent (roughly equal) origin efficiencies, but the assay doesn't distinguish between all going up to high efficiency or all going to a lower intermediary efficiency. Given that fork factors (polymerases, etc) are likely to become limiting at some point (or checkpoints could be activated due to limited dNTP supplies) it would seem plausible that uniform origin efficiency could be a consequence of less than maximal origin firing. As part of this discussion it would be useful for the authors to include what conclusions have been reached on MCM load from in vitro systems (with chromatin substrates).

      Because the main focus of the paper is not dependent on whether MCM stoichiometry varies from 0 to 1 or 0 to many, we had relegated our discussion of absolute stoichiometry to the Discussion. However, it is clear from multiple reviewer's comments that it is something very much on readers minds. Therefore, we have now included a brief introduction to the 0-to-1 and 0-to-many scenarios in the Introduction and moved the bulk of the discussion of the data supporting the two scenarios to the Discussion.

      2.The authors are not the first to look at the consequence of reduced MCM concentrations on origin function. This was essentially the basis for the MCM screen undertaken by Bik Tye's lab that first identified the MCM genes. In addition to temperature sensitive mutants, the Tye group also examined heterozygotes (Lei et al., 1996) to show differential effect on the ability of two origins to support plasmid replication. The authors finds are entirely consistent with these early studies, particularly since ARS416 (formerly ARS1) was found to highly sensitive to reduced MCM levels and ARS1021 (formerly ARS121) was found to be insensitive to MCM levels. The authors find a signifiant reduction in MCM load at ARS416, but the MCM load at ARS1021 is unaltered by reduced MCM concentration. It would be worth the authors noting this consistency. The authors do cite the Lei study, but not in this context. The original MCM screen was published here:

      Maine, G., Sinha, P., Tye, B. (1984). Mutants of S. cerevisiae defective in the maintenance of minichromosomes Genetics 106(3), 365 - 385.

      Furthermore, at the end of the discussion the authors state that "it will be interesting to dissect the specific cis- and trans-acting factors that make origins sensitive or resistant to changes in MCM levels". The equivalent effect reported by the Tye lab has already been dissected by the Donaldson lab (Nieduszynski et al., 2006) and perhaps it would be worth briefly mentioning their findings.

      We have included both of these literature precedents in the Discussion.

      3.The authors should show the flow cytometry data for each of their cell cycle experiments, if only in supplementary figures. This is important to allow a reader (and reviewer) to judge the level of synchrony achieved when interpreting the results.

      This data is now included as Figure S1

      4.I think the authors should show the ChIP signal at some example origins, including ones sensitive and insensitive to the reduction in MCM concentration. Currently all the high resolution ChIP data (i.e. over 1400 bp, e.g. Fig 3a) is presented as meta-analyses of many origins.

      We will include this analysis in a subsequent revision.

      5.When describing the results in Fig 4a the authors focus on changes (highlighted in black boxes) that fit their expectation. However, there are other sites that should at least be mentioned that don't seem to fit the authors model, e.g. ARS517, ARS518. It would be worth discussing what fraction of the timing data can be explained by the reduced MCM load.

      We now explicitly point out that Figures 4c and 4d address this issue of the robustness of the correlation. Although there is significant variation, as the reviewer points out, the trend is seen genome wide. As it happens, both ARS517 and ARS518 do fit the model reasonably well. They have intermediate loss of MCM signal and intermediate delay in timing.

      **Minor comments**

      -These data, rather than this data (throughout).

      I suspect that the journal style and/or copy editors will make the final call. However, I will point out that although 'data' is most certainly plural in Latin, its predominate modern English usage is as a mass noun, such as water or sand or information. In general, users do not think of, or use, 'data' as a collection of discrete elements, each on being a 'datum', a contention supported by the very infrequent use of the word datum. For instance, in ChIP-seq experiment, what is a datum? Each individual read? Each individual nucleotide in each read? The quality score for each individual nucleotide in each read? Each pixel in each image from the sequencer? When one wants to refer to an individual piece of data, common usage is to refer to a data point, just as one would refer to a grain of sand. Moreover, if 'data' were plural, it would be incorrect to use it in phrases such as "there is very little data available". Would the review really suggest using "there are very few data available"?

      -the authors should clearly state in figure legends what window size has been used in analysing genomic data.

      All analyses were done using 1kb windows, as now stated in the figure legends.

      -in figure 2a the authors show pairwise comparisons between conditions, it would be nice to see the 3rd pairwise comparisons perhaps as a supplementary figure

      We have included the third comparison in Figure 2a.

      -in figure 2c it would be clearer to use the same colour for the lines and the points

      The regression lines are in the same colors as the data points they fit. x=y is shown in blue for comparison, as now noted in the figure legend.

      -the authors should avoid the use of red/green colour combinations in their figures (see: https://thenode.biologists.com/data-visualization-with-flying-colors/research/)

      All figures will be redrawn in colorblind-accessible colors in a subsequent revision.

      -in the text the authors state "ORC binding to the ACS and subsequent MCM loading is a directional process dependent on a ACS- site and a similar but inverted nearby sequence (Xu et al., 2006)". I think it would be more appropriate to cite the following study here:

      Coster, G., Diffley, J. (2017). Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading Science (New York, NY) 357(6348), 314 - 318. https://dx.doi.org/10.1126/science.aan0063

      The Coster reference has been included.

      -the list of factors that influence replication timing should include Rif1, whereas it is less clear that Rpd3 acts within the unique genome (as opposed to indirectly via repetitive DNA, e.g. rDNA)

      Rif1 has been added to the list.

      -figure 4 - it might help to mark the centromere on panel a. Also, why do the ChIP peaks and annotated origins appear to line up so poorly?

      The shift between the peaks and the ACS positions was introduced during the construction of the figure. Thanks for catching it. The alignment has been corrected and the centromere annotation has been added.

      -figure 4d - would it not be better to use fraction of lost MCM signal on the x-axis as in previous figures?

      If T_rep was a linear function of MCM stoichiometry, fraction lost would work as well as amount lost. However, we find that there is a lower correlation between fraction of MCM signal lost and T_rep delay than between absolute MCM signal lost and T_rep delay, suggesting a more complicated relationship.

      -"with galactose or raffinose, to induce or repress Mcm2-7 overexpression, respectively." This is incorrect, raffinose does not repress this promoter (that requires glucose).

      Fixed.

      -the S. pombe spike in is a great addition to the over expression experiments. It's a shame that it wasn't included in the auxin experiments.

      Yes, we agree.

      -why does the data in fig 5d appear to be at much lower resolution that the previous ChIP data?

      The resolution was inadvertently reduced during the rendering of the figure. The resolution has restored.

      -in the sequencing analysis pipeline for MCM ChIP the authors use a 650 bp upper size limit; why have such a large threshold compared to the size of a nucleosome? Are the analyses and findings sensitive to this size threshold?

      Although the MNase digestion was optimized to produce mostly mononucleosomal-sized digestion, some di- and very little tri- nucleosomal fragments still remain. In order to capture as many of the MCM-protected immunoprecipitated fragments as possible, the upper limit was set at 650 bp (up to 4 nucleosomes-worth of DNA). However, there is a very minimal contribution from fragments larger than mononucleosomes, qualitatively as well as quantitatively in 1kb windows around origins. Figure 3a provides a qualitative depiction of the contribution of dinucleosomes (input, ~300bp).

      -the repliscope package was published here:

      Batrakou, D., Müller, C., Wilson, R., Nieduszynski, C. (2020). DNA copy-number measurement of genome replication dynamics by high-throughput sequencing: the sort-seq, sync-seq and MFA-seq family. Nature Protocols 15(3), 1255 - 1284. https://dx.doi.org/10.1038/s41596-019-0287-7

      The reference has been corrected.

      Reviewer #1 (Significance):

      This work builds upon a body of work from the Rhind group (and others) to determine the contribution of MCM load to replication origin activation dynamics. To my mind this is the most convincing dataset and analysis to date and goes a long way to supporting the model that the efficiency of MCM loading is a major factor in determining the mean replication time of an origin. As the authors state, they are still not able to distinguish between two different models of MCM load (single vs multiple). It would be interesting for the authors to discuss how these two models could be distinguished in the future (perhaps with single cell/molecule experiments).

      This study will be of interest to those in the fields of DNA replication and genome stability.

      My field of expertise is DNA replication and replication origin function.

      Reviewer #2 (Evidence, reproducibility and clarity):

      **Summary:**

      This is a nice study that characterizes the consequences of limiting or increasing Mcm expression on the replication program. Prior ChIP experiments in yeast have observed that not all origins exhibit the same level of Mcm enrichment and that increased mcm enrichment was correlated with origin activity. These observations led to two different models -- a) that multiple Mcm2-7 double hexamer complexes are loaded at some origins and b) a probabilistic model where the differential enrichment of Mcm2-7 reflected the fraction of cells in a population that had loaded the Mcm2-7 complex at a specific origin. While the titration experiments presented here don't provide any conclusive support for either model, they do provide some novel and relevant insights for the replication field, in part, due to the increased resolution and quantification afforded by the MNase ChIP-seq approach (and S. pombe spike in). The authors very nicely demonstrate that origins are differentially sensitive to Mcm2-7 depletion and that loss of Mcm2-7 loading results in an altered replication timing profile. The origins most impacted by loss of Mcm2-7 are 'weak' origins as described by the Fox group. Intriguingly, the authors find that the 5X overexpression of Mcm2-7 does not perturb the relative Mcm2-7 loading at individual origins, but rather instead globally represses Mcm2-7 association at all origins. They also find that overexpression of both Cdt1 and Mcm2-7 is detrimental to the cell (although no obvious replication phenotype was observed). Finally, the authors present a reasonable interpretation of their data in the context of models for replication timing which was very well articulated.

      **Major Comments:**

      From the methods it appears that different analyses were performed with different replicates?

      "Replicate #1 was used for all analyses except for V plots, for which the higher resolution Replicate #2 was used."

      Ideally all of the conclusions should be supported by all the replicates independently, or if the replicates are concordant -- they should be merged (at a similar sequencing depth) prior to doing the analyses.. Even the v-plots with merged replicates will be informative due to the greater sequencing depth.

      Though we agree that greater sequencing depth would be informative for aggregation analysis, we think that one of the main strengths of our study is the analysis of MCM quantitation and replication timing in the same population of cells. Although the experiments were performed in exactly the same way, there is always slight biological or temporal differences between the replicates, due to the complicated nature of the experimental design. This variation increases the noise between the MCM ChIP and the replication timing analyses. Therefore, were analyzed the replicates separately. However, we did do all of the analyses on both replicates and got similar results. We have now explicitly stated as much.

      The authors should provide a separate analysis for the larger nucleosomal sized fragments and smaller putative MCM double hexamer fragments with regards to the Mcm loading and relationship to ACS and orientation. They may represent an interesting intermediate with mechanistic consequences for the interpretation.

      We will include the suggested analysis in a subsequent revision.

      The authors should present the v-plots and an analysis of which side the Mcm's load for the overexpression studies. I was surprised that there was no further in-depth analysis for these two extremes. Perhaps similar conclusions will be reached, but it should at least be mentioned/presented as a supplementary figure.

      We will include the suggested analysis in a subsequent revision.

      **Minor Comments:**

      This is largely semantic, but the majority of MNase ChIP-seq signal recovered is associated with the nucleosomes and not in the NDR and as the signal in the NDR is differentially sensitive to digestion, I would suggest rephrasing the following sentence:

      "In contrast to previous genome-wide reports (Belsky et al., 2015), but in agreement with recent in-vitro cryo-EM structures (Miller et al., 2019), we also observe MCM signal in the nucleosome-depleted region (NDR) of origins. "

      to :

      "In agreement with a previous genome-wide report (belsky 2015), we found that the bulk of the MCM signal was associated with nucleosomal sized fragments; however the increased resolution afforded by our approach allowed us to also detect protected fragments in the NDR as predicted by recent in vitro cryo em structures..."

      We have modified the sentence as suggested.

      As a sanity check, please double check V-plots and presence of small fragments with the digestion conditions. In the Henikoff manuscript the bulk of sub-nucleosomal fragments were lost with the longer digestion time. Specifically, the TF footprints were more pronounced with minimal digestion. While it might be argued that the longer digestion more tightly resolved the binding site, in many cases they were completely lost with the 20 minute digestion. This is just a simple check -- I don't doubt the results as reported given the experimental conditions are very different. For example, the henikoff manuscript did not use cross linking or an antibody enrichment step.

      We double checked and confirmed that more small fragments are found in the more digested library. The reason that we see more small fragments when we digest more, in contrast to the contrary observation in the Henikoff paper is presumably because MCM has a larger footprint than a transcription factor and protects that footprint more effectively.

      Last paragraph of the "MCM associates with nucleosomes section" which reports that the Mcm2-7 complex is loaded up or downstream from the ACS independent of orientation should cite Belsky 2015 (Figure 5 and discussion) for the initial observation.

      Done.

      The authors argue that the global reduction in MCM loading associated with overexpression may be a technical artifact given that all origins exhibit a proportional reduction in mcm2-7 loading. However, this is exactly what the S. pombe spike in control is intended for. The relative difference between individual origins resulting from Mcm2-7 depletion would still be evident without the spike in. The authors do discuss different possibilities, but I would not be so keen to discard this as technical artifact.

      We, too, are reluctant to dismiss this result as a technical artifact. However, we are at a loss to offer any other explanation. We raise a handful of biological possibilities in the Discussion, but dismiss each one as failing to account for our results. We would be happy to entertain other suggestions.

      Reviewer #2 (Significance):

      This work has several advances that will be appreciated by the replication field -- including a high resolution view of Mcm2-7 loading in the context of chromatin; the impact of titrating (low and high) MCM expression on MCM loading and replication timing program; and a well reasoned discussion of how different models of MCM loading would impact origin activation and replication timing program. The work builds on prior studies in the field (eg. Belsky 2015), while some of the conclusions regarding the localization of the Mcm2-7 complex relative to the ACS and surrounding nucleosomes are confirmatory, the increased resolution provides new insight (like the enrichment of small fragments in the NDR) that could be further strengthened by additional analysis (see above).

      My expertise is DNA replication and chromatin.

      Reviewer #3 (Evidence, reproducibility and clarity (Required)):

      In this study, the authors use Auxin-mediated degradation of Mcm4 to reduce the concentration of the MCM helicase complex in yeast, and determine the effects of this reduction on both MCM-origin association (interpreted as MCM loading) by MNase-MCM-ChIPSeq and on replication origin function by Sync-Seq replication timing experiments (deep sequencing of a yeast population as it progresses through a synchronized S-phase). Complementary experiments testing the effect of induced MCM complex over-expression on MCM-origin association are also performed.

      The authors find that reducing Mcm4 levels (and thus loading-competent MCM complexes) causes yeast cells to be more sensitive to DNA replication stress. In addition, not all origins are equally susceptible to reductions in MCM levels; the origins that do lose MCM binding at reduced MCM levels show a reduction in activity and an associated delay in their replication time under those conditions. Finally, over-expression of the MCM complex has no effect on MCM-origin association or origin function, suggesting that MCM levels are not limiting for origin licensing in yeast under normal lab conditions. The strengths of the study are the well-executed experiments and very nice data that are presented. However, there are several weaknesses. The authors make conclusions that are not supported by their data; and several of the outcomes are not at all unexpected based on extensive published studies in yeast and mammalian cells, raising issues about whether this study advances and/or clarifies the current gaps in the field. While some of the relevant past studies were referenced, the authors did not place their own study in the context to published work and current models in the field, which reduced the scholarly value of their study. Because the work was not placed in context of the field, some of the rationale and conclusions were misleading.

      **Some specific major comments:**

      1,The title is misleading. The authors have clearly shown that when MCM levels are be made limiting in an engineered system, some origins are substantially less active, which means that these origin loci are replicated "passively" (i.e. by a Replication Fork (RF) emanating from a distal origin) rather than actively (i.e. by "firing" and initiating replication). Their own replication data show that. But this competition is only revealed when MCM levels are artificially/experimentally lowered. What is the evidence that competition for MCM complexes among individual origins establishes replication timing patterns in yeast? If anything, the over-expression experiment suggests the opposite--that MCM levels are not limiting and therefore do not play a substantial role in establishing the replication timing patterns that are observed in yeast. Instead those patterns appear to result primarily from the fact that MCM complex activation factors are present in limiting concentrations relative to origins.

      We agree with the reviewer's analysis and have revised the title to "The Capacity of Origins to Load MCM Establishes Replication Timing Patterns".

      2,The abstract states that "the number of MCMs loaded onto origins has been proposed to be a key determinant of when those origins initiate DNA replication during S-phase". While it is true that this lab has proposed this model in budding yeast, the current study performs no experiments that directly address this model--i.e. that i. individual origins possess a different number of MCM complexes and or ii that these differences underlie timing differences. They acknowledge this point in their Discussion--a ChIPSeq experiment is an ensemble experiment--there is no way to know that differences in MCM signals correspond to a different number of MCM complexes per origin versus a differences in the fraction of cells that contain and MCM complex at all at a given origin . But this statement in the abstract, combined with their conclusion in the same section of the paper: "Our results support a model in which the loading activity of origins, controlled by their ability to recruit ORC and compete for MCM, determines the number of helicases loaded, which in turn affects replication timing" implies that they have tested a model that they have not tested. Given how quickly readers "skim" the literature these days, a misleading abstract can do a lot of damage to a field. The results presented in this study neither support nor refute the model for the number of helicases loaded per origin, and the fact that reducing origin licensing efficiency by making the major substrate limiting reduces the number of licensed origins in a cell population is fully expected based on the current state of the field .

      Four questions are addressed in this comment. The first is whether there is variable MCM stoichiometry at origins. The second is whether that variation ranges from 0 to 1 and 0 to many. The third is if the variation is stoichiometry affects replication timing. The fourth is how this variation in stoichiometry comes about.

      Our work is based on the conclusion, supported by a substantial body of literature, that MCM loading stoichiometry varies among origins. Our data in this paper further supports this conclusion.

      As the reviewer notes, and as we had tried to make clear, the data is this paper does not address the range of the variation. Moreover, as we also tried to make clear, our hypotheses, results and conclusions are not affected by whether the range is 0 to 1 or 0 to many.

      This paper focuses on Questions 3 and 4. We have reworked the introduction to make these distinctions more clear.

      We have also corrected the abstract to refer to "the stoichiometry", instead of "the number", of MCMs.

      3,The rationale for the study as stated in the Introduction: "Although the molecular biochemistry of initiation at individual origins continues to be elucidated in great detail (Bleichert, 2019), the mechanism governing the time at which different regions of the genome replicate has remained largely elusive (Boos and Ferreira, 2019)." Is also misleading. In fact, in budding yeast (and other organisms) there have been several advances in this area particularly with respect to DNA replication origin activation. The S-phase origin activation factors are limiting for origin function, and factors such as Ctf19 at centromeres and Fkh1/2 at non-centromeric early-acting origins help to directly recruit the limiting S-phase factor, Dbf4, to origins. It is misleading to ignore this substantial progress and not make an effort to place this current study, which is important and one of the first to look directly at MCM loading control in yeast, into a relevant context with respect to what is known. What's interesting is that this S-phase model assumes/requires that most origins are, in fact, licensed and thus that differences in licensing efficiency are not a major driving of replication timing patterns in yeast. But we do not know why there are only subtle differences in MCM loading---this study may help explain that.

      We have broadened the scope of our Introduction and Discussion to address these points. However, it is not the case that "there are only subtle differences in MCM loading". MCM ChIP-seq (, and this paper) and MCM ChEC-seq both show well over ten-fold variation in MCM stoichiometry at origins. We have now explicitly made this point in the Introduction.

      4,The authors link the differential ability of MCM loading deficiencies when MCM is made limiting to differences in ORC binding categories. The "weak" origins, that presumably bind ORC weakly, were most affected by reductions in MCM. Are these origins less efficient than the other categories, DNA and chromatin-dependent (using the origin efficiency metric data from the Whitehouse lab) where MCM binding is not reduced as much? In normal cells are these early or late origins? Is the idea that the role of excess MCM is to achieve a sufficient number or "back up" origins per cell to deal with potential stress, as proposed by the Blow and Schwob labs in tissue culture cells many years ago? It seems likely that the data reported here are in fact confirmations of those early studies in mammalian cells---which is useful to know even if not unexpected.

      We will include the suggested analyses in a subsequent revision.

      Excess MCM do, as has been long appreciated and as we discuss, contribute to replication-stress tolerance. However, that is not a major point of our paper.

      5,Aren't the results that losing MCM signal corresponds to loss of origin activity peaks entirely expected? The same result would be obtained if you made a point mutation in that origin's ACS. Of course preventing an origin from being licensed will delay that region's replication time in S-phase because it now must be replicated passively. Licensing affects replication timing patterns because the MCM complex is the substrate for limiting S-phase factors, but that is far different from concluding that the number of MCMs at an origin is what controls the time in S-phase when an origin is activated.

      Yes, "the results that losing MCM signal corresponds to loss of origin activity peaks [are] entirely expected". However, this is not the important result. The key result is that the distribution of MCM at origins is not uniformly affected, which leads to our conclusions that, in wild-type cells, origin capacity dominates MCM stoichiometry and that, when MCM become limiting, origin activity (probably determined by ORC affinity) becomes critical—neither of which were expected results. In any case, the expected correlation between MCM loading and origin activity was observed as a consequence of measuring MCM stoichiometry and replication timing and is an obvious analysis to include, so we did so.

      6,The authors stated that the measured MCM abundance for the 43% of origins that are not known to be controlled by the multiple mechanisms that have been shown to control origin replication time. Is this because they think that MCM loading contributes to the timing control of only these origins? Was MCM loading not affected at any of these other origins when MCM levels were reduced? Are those 43% of origins in the "weak" binding category in terms of ORC? The rationale for eliminating so many origins from these analyses were not clear.

      We propose that the probability of origin activation is the product of the stoichiometry of MCM at the origin and the rate of MCM activation, which may be affected by trans-acting factors. For the 43% of origins for which there is no known trans-acting regulation, the correlation with stoichiometry is stronger. However, the correlation holds when looking at all origin, too. The suggestion to look at only the 57% of origins with known trans-action regulation is a good one. We will include this analysis and the other suggested analyses in a subsequent revision.

      7,Doesn't the data in Figure 4c at 0 mM auxin support the conclusion that differences in MCM ChIP signals have negligible effects on origin activation time, in contrast to the publication by Das, 2015 from this lab? Or is the point that these origins are sensitive to reductions in MCM levels and the more sensitive they are the more delayed their replication time (but again, doesn't that have to be true? If they are losing MCM signals they cannot function as origins, so they are replicated passively and, by definition, will show delayed replication timing. An origin is defined as such by a loaded MCM complex.)

      No. The reason the correlation in 4c is not a good as in our previous work is that in Das 2015 we compared origin-activation efficiency (calculated from our stochastic model in Yang 2010), instead of T_rep, which we used here. T_rep is a convolution of origin-activation time and passive-replication time, reducing to correlation. The important observation is that the correlation gets better as MCM levels are reduced.

      The correlation between MCM stoichiometry and activation efficiency may seem trivial, but just because a model is simple does not mean it is not correct. If stoichiometry was the only factor regulating origin activation, we would expect a stronger correlation. So, we conclude that there are other factors at play, quite possible the trans-acting factors that the reviewer mentions in their second point. However, if stoichiometry played no role, we would expect no correlation. So, we propose that MCM stoichiometry is "an important determinant of replication timing".

      8,I do not understand the conclusions from Figure 4d. There is an extremely small positive correlation between how much of an MCM signal is lost and delay in replication time of an origin, but this correlation is not surprising as an unlicensed origin cannot be an origin and will be replicated passively. What seems most surprising about these data is that the effect is so weak, not that it exists. There is quite a lot of scatter in this plot at 500 uM auxin, with some origins losing a given amount of signal (x) and being only slightly delayed in replication time, and others losing the same amount of signal (x) and being substantially delayed. What underlies this outcome?--Are the ones that are not substantially delayed closer to origins that have not been affected at all by MCM reductions? Why is the correlation so weak? The other regulators of origin activation time have stronger and more precise effects--for example the centromere-control can be precisely eliminated so that only the replication time of the centromere-proximal origins are delayed.

      We believe that much of the noise in Figure 4d is due, as the reviewer suggests, to passive replication of origins which lose most of their MCM signal and become inactive but happen to reside next to origins which don’t lost any MCM signal and fire early. And excellent example is ARS 510 (see Figure 4a). ARS510 loses most of its MCM signal and clearly loses its initiation peak in the T_rep plot. However, because it is next to ARS511, which does not lose much MCM signal and which remains a efficient origin, ARS510 is still replicated early. We will include this example in a subsequent revision.

      9,Multiple studies in yeast and mammalian cells indicate that MCM subunits are in excess relative to other licensing and S-phase initiation factors, so it is not unexpected that over-expressing MCM did not lead to enhanced levels of licensing. It seems much more plausible that Cdc6 or Cdt1 or both factors are present in limiting amounts for MCM loading, so I did not understand the point of over-producing MCM subunits. If the "weak" origins are the ones that are most dramatically affected by reducing MCM to "limiting" levels, isn't the question whether you can increase licensing at these origins when you over-produce a factor that is likely limiting for licensing, such as Cdt1 or Cdc6 (or both) while leaving MCM at its normal levels. The fact that MCM levels are not limiting for licensing is not surprising and, if anything, argues against these levels having a regulatory role in origin activation timing---which seems to be the opposite of what the authors want to conclude.

      Orc1-6, Cdc6 and Cdt1 are all substoichiometric to MCM. However, they all act catalytically to load MCM. So, although they may be kinetically limiting, they do not prevent most or all MCMs being loaded in wild-type cells. The fact that overexpressing MCMs (with or without Cdt1) does not allow for more MCM loading suggests that under normal conditions origins are saturated with MCMs and have little or no capacity to load more MCM, even when given plenty of time to do so. From this result, we conclude that origin capacity is a major determinant of MCM loading in wild-type cells. From our MCM-reduction experiments, we also conclude that, when MCM is limiting, origin competition affects which origins load MCMs faster. However, we agree with the reviewer's first point, that our title gave the incorrect impression that we concluded that origin competition is the primary determinant of MCM loading in wild-type cells. Thus, as suggested, we have changed the title. We have also reworked the Introduction and Discussion to more clearly explain that competition is only a determining factor when MCMs are limited.

      In summary, I think the technical aspects of the experiments were quite strong, but I do not think that the experiments answered the question that was posed by the authors.

      **Minor points:**

      Many places where "This data" should be changed to "These data". Data are plural.

      See comments on this point in the response to Reviewer #2.

    1. These machines are the first general purpose computers ever where you have to make an exclusive choice: you can have a fast and efficient machine, or you can have a private one.

      Worse still

      The enclosure of the jewel in the digital commons Linux the operating system built to preserve your freedom as is accelerated by Microsoft. Started by buying Github, and now turning windows into a Linux distribution

    2. Your Computer Isn't Yours

      I do not see a reference to Linux

      The enclosure of the jewel in the digital commons Linux the operating system built to preserve your freedom as is accelerated by Microsoft. Started by buying Github, and now turning windows into a Linux distribution

    1. The Shamrock was built of sun-dried bricks, of an unhealthy, vomit-grey tint. Its dirty, shattered windows were plugged in places with old hats and discarded female apparel, and draped with green blinds, many of which had broken their moorings, and hung despondently by one corner.

      Understanding the Passage:

      (i) What imagery has been used to the Shamrock? (recognize literary devices)

      (ii) What feeling does this description gives to readers? (Identify impact)

    1. Reviewer #2:

      This study performs behavioral assessment of the impact of watching lip movements on tone detection in noise and EEG recordings from passive observers of the same movies. The basic paradigm is that listeners watch a silent movie of lip movements (selected to be at ~theta rate) while listening for tone bursts that occur most commonly twice in a trial (early and late). The key findings are that perceptual sensitivity is higher when tones are in the second half of the trial, when hits align at a particular phase angle of the visual stimuli. Brain signals were also observed to entrain through the course of the trial. The authors conclude that visual modulation of auditory excitability explains these effects.

      The stimulus design is elegant, and if taken at face value are a nice demonstration that visual stimuli can modulate auditory perception in a temporally specific manner. However, I have concerns with the interpretation of the data while also feeling to some extent that these findings are expected; stimulating AC with a speech envelope modulates speech perception (Wilsch et al., 2018), silent speech modulates human auditory cortex (Calvert 1999) and visual stimuli modulated at theta rates directly entrain auditory cortical phase in animals (Atilgan et al., 2018) as do audiovisual speech stimuli in humans (Zion-Golumbic et al., 2013). This study is a further piece of evidence along these lines, but it's hard to be certain of a causal relationship when the behaviour and neurophysiology are in different listeners. I also have some concerns about the current interpretation some of which are addressable with additional analysis.

      I'm not convinced that the authors have sufficiently ruled out the possibility that the first tone causes a phase reset in AC that causes detected second tones to be entrained to a particular stimulus phase. In theory this should be easily addressed by looking at the 1 tone trials where the tone is in the second half of the stimulus. These data are in the supplemental material but are not particularly reassuring - while the d' is higher for the second tone, but the phase angles are uniformly distributed across participants in comparison to the clustering observed in the 2-tone data. This finding calls into question the causal link between the phase relationship and performance. The authors note that there are relatively few trials (50% of those available in the 2 tone data) - the contribution that this plays could be addressed by subsampling half the trials from the 2 tone dataset and re-estimating the phase modulation to estimate whether the single tone condition is any different. Another analysis that could be enlightening/ reassuring would be to compute the phase of the hits to tone 2 relative to the onset of tone 1 using the modulation rate of the clip (or 6 Hz, if clips were selected to be that anyway).

      I would like to see the distribution of the tones w.r.t. the phase of the lip movement (all tones, not just hits) to be reassured that there is nothing inherent in the movies that causes the phase alignment?

      The neurophysiology does not demonstrate a significant increase in entrainment from early to late windows, only that there is a different phase angle. Doesn't this also call into question the conclusion that performance is better in the second half due to better entrainment? While the phase in the second might be 'more efficient' if the entrainment is equivalent shouldn't there be a behavioural relationship in both cases? This is where performing both behaviour and EEG simultaneously (or at least in the same listeners) may have proved enlightening.

    2. Reviewer #1:

      In this manuscript, the authors report on two separate experiments designed to understand the relationship between lip-movement induced theta phase and auditory processing. In the first experiment, subjects detected tones embedded in noise while viewing silent videos. The results demonstrate that tone detection performance improved when tones are presented later relative to earlier in a trial. It was also demonstrated that correct detection, for tones that occurred later in the trial, was systematically linked with the phase of the theta oscillatory activity conveyed by the lip movements. In the second experiment EEG was recorded while participants viewed the silent videos and performed an emotion judgement task. Theta phase coupling was demonstrated between auditory and visual areas such that oscillations in the visual cortex preceded those in the auditory cortex.

      The authors conclude that these results demonstrate that lip movements directly affect the excitability of the auditory cortex. However, due to the indirect nature of the reported effects, I do not believe this conclusion is justified. I elaborate on this concern below:

      1) In experiment 1, the main finding that performance is better later in the trial could arise from many factors including non-specific attentional effects.

      2) The analysis reported in the bottom of page 5 (comparing vector lengths for hits vs misses) is critical to the argument but the results are inconclusive (significant interaction, but subsequent comparisons not quite significant. Likely because the experiment is underpowered?).

      3) In Experiment 2: the task performed by the listeners might have biased them towards speech imagery leading to the pattern of effects observed. Indeed, the observed involvement of the left hemisphere may be consistent with the involvement of speech imagery. This would render the observed link between visual and auditory cortices as somewhat trivial and not new (such links have been reported in many previous studies as acknowledged by the authors).

      4) Most importantly, the authors do not provide any direct evidence that the auditory effects observed in Experiment 2 are related to those observed in experiment 1.

      Other comments:

      1) For the analyses in Figure 2A, were the number of trials over which the analysis is conducted adjusted for "first tone" vs "second tone"? Since the hit rate is higher for the second tone, there may be a concern that including more trials in the analysis would result in better SNR and hence a more robust effect.

      2) In Experiment 2 the analysis is focused on phase effects. Can you report whether there are any power differences in the delta band in the "early" vs "later" time windows?

      3) Line 176, the authors write "these results established that entrainment of theta lip activity increased in time". It is not clear to me which aspect of the results supports this statement.

      4) Line 405: "any lag between visual and auditory stimuli onsets was later compensated...". I could not find mention of this elsewhere (i.e. how lags were compensated, how large they were). This is critical for interpreting the results and therefore should be described in detail.

      5) Line 430-437 why did you choose to quantify the envelope in this way rather than just taking the wide band envelope?

      6) Figure S3 is important and should be in the main text.

      7) Line 473 "auditory pure tones"

      8) The description in lines 478-481 doesn't make sense. It is unclear how loudness reported in line 480 (91dB SPL; incidentally this is very loud) relates to the later reported value of 72dB SPL.

      9) Line 485 "embedded"

      10) Please clarify whether in your loudness adjustment procedure you were adjusting the loudness of the tone, the noise or the SNR (and thus keeping the overall loudness of the stimulus fixed)

      11) Line 537 "preceding"

    1. A poor, bare, miserable room it was, with broken windows, no fire, ragged bedclothes, a sick mother, wailing baby, and a group of pale, hungry children cuddled under one old quilt, trying to keep warm.

      Understanding the Passage:

      What is the mood presented here? (Infer setting)

    1. It was October and the weather still had not turned. The night was sweltering, and we had the air-conditioning on and windows shut.

      Understanding the Passage:

      What purpose does the description of weather play at this point of the passage? (identify literary device)

    1. “Ways of hearing’’ describes the impact of space and sound on people’s lives. Krukowski mentioned that “people wear headphones to avoid ear contact.” Whether on the street or on the subway, we can find that most people ignore many things around them and immerse themselves in their world with headphones. I feel the same about this. I don’t know when it has become a habit to wear headphones before going out. Compared to the noisy roads and noisy subways, I seem to be more willing to wear headphones to isolate myself from the world, and no longer listen to each other better and lack patience with things. After a long time, it seems that I am no longer interested in the sounds of the city. People have become more chasing for quality sound. For example, we are willing to pay to go to concerts. With the development of society and technology, people began to control sound and make the sound beautiful. Although this improves our quality of life, it also leads people to always ignore the most primitive and natural things. We should open the windows and remove the headphones to feel the special charm of the city. 

      Interesting points

    1. In a Command Prompt window, you can attach to a running process when you launch CDB. Use one of the following commands: cdb -p ProcessID cdb -pn ProcessName where ProcessID is the Process ID of a running process or ProcessName is the name of a running process.

      ProcessName 就是 proeforth.exe

    1. because they believe the lesbian, gay, bisexual and transgender event had become too celebratory without focusing on those who are still marginalized.

      who are they to decide this wut

    2. I also think it’s important to attack the symbols of capitalism. It’s just property at the end of the day.”

      more than just anti gov, anti capitalist too

    3. The group decided to use “black bloc” tactics, wearing dark clothes and masks so that authorities would have a harder time identifying — and convicting — participants

      well at least they work together, i see the desire for a community of like minded indvs

    4. hat’s a moment where anarchists are ready to respond in a way that many others aren’t,

      seem braver and more ready to confront these types of things

    1. well they say moving to windows seven would be a fresh start but the real fresh start would be moving to a computer like Mac who's rated number one

      The user thinks out loud and discusses with herself if she should move to a better PC or to a new Mac. She gives different pros and cons for each side but at the end, she decides for Mac.

    1. The closest we came to real reading was giving them books, then reading out loud to them. They rebelled. They hated the class. They didn’t come or they acted up when they attended. They didn’t do the work. I said things like, “These kids just don’t want to learn” and “These kids don’t care about their education.”

      I think this is very common among students today. I believe many students do this because many curriculums and units do not reflect them. They aren't invested, they don't have buy in because these lesson/books were not chosen or implemented with them in mind. This is the idea of "window and mirror" texts. Many texts are merely windows for the students they are not mirrors that reflect themselves.

    2. Choosing the books that provide just the right balance of mirrors and windows can be difficult but it is so important. Last year, while teaching 5th grade in Chicago I was given a curriculum that was designed for inner city schools. Most of the books were targeted for African American students, my students were 98% Latinx. The two books in the set that included Latinx characters were horrible misrepresentations and stereotypes. I had to use the books so we read them and had discussions on perceptions of culture and who my students were as people.

    1. Reviewer #2:

      The paper titled "Brain Network Reconfiguration for Narrative and Argumentative Thought" sought to uncover the common neural processing sequences (time-locked activations and deactivations; inter-subject correlations and inter-subject functional connectivity) underlying narrative and argumentative thought. In particular, the study aimed to provide evidence that would help adjudicate between two current theories: the Content-Dependent Hypothesis (narrative argumentative) and the Content-Independent Hypothesis (narrative = argumentative). In order to assess these possibilities they tested participants in an fMRI scanner as they listened to validated narrative and argumentative texts. Each text condition was directly compared to resting state and scrambled versions of the texts. Across a range of interesting analyses that focus on how each participant's brain synchronized with other participants' brains throughout the same narrative and argumentative texts, they primarily found support for the content-dependent hypothesis with a few differences and commonalities across text conditions. Relative to the scrambled conditions, listening to narrative texts was more associated with default mode activity across participants and listening to argumentative texts only activated a common network of superior fronto-parietal control regions and language regions. Argumentative texts did not differ much from scrambled versions of the same text. These patterns reveal themselves in both ISC and ISFC data. Overall, I feel like this paper is really well written and is a novel approach to distinguishing the neural processes between similar, but different types of thought. At times the manuscript loses touch with its primary brain coordination metrics (ISC and ISFC), describing the findings more like a GLM or functional connectivity study.

      Comments:

      Introduction:

      1) The introduction is very clearly written and uses a wonderful variety of sentence structure. Well done!

      2) While the writing is beautiful, a few sentences are less easy to comprehend than others. For example the use of outstands in line 36 is a bit difficult to parse on first read. Consider simplifying the language some.

      3) There seems to be an opportunity to discuss this work and its findings in a broad context of narrative or argumentative self-generated internal thought (not based on listening to texts). For instance, I think there could be a few sentences tying this work to studies of autobiographical memory retrieval or mind wandering (for argumentation perhaps studies of the cognitive and neural processes behind complex decision making). This is captured to some extent in the introduction and discussion, but I think it could go further with citations beyond those just associated with listening to various types of text.

      4) Appreciate the thorough discussion of hypotheses and background.

      5) It is not necessary, but it might be interesting to show some basic functional connectivity analyses of the individual participant activations in supplemental analyses (no ISC or ISFC).

      Methods:

      1) Please clarify how the ISFC analysis can be directional in any way? Does unidirectional mean that you're just taking one value for each pairwise connection Cij?

      Results:

      1) To what extent is there a concern that participants would still try to stitch together the scrambled narratives even if they are less coherent? Was this even possible given the nature of the stimuli?

      2) In line 125 and throughout the authors should consistently remind the reader that 'engagement' in this case means that there were consistent and correlated increases in the bold response across participants. This differs in some ways to task engagement in event-related GLM studies.

      3) The language throughout should reflect consistent involvement across participants at particular time points in each of the narratives vs the argumentative.

      4) It seems like argumentative is more similar to the scrambled in many ways. Might it be that argumentative texts are just less coherent and structured than narrative texts?

      5) It seems clear that the neural processing of argumentative texts (64 distinct edges) were very different from the narrative texts (2348 distinct edges), but that the current contrasts did not clearly and consistently distinguish argumentative thought from the scrambled argument conditions. A discussion of the analyses that might be necessary to better elucidate the dynamics of processing for argumentative thought would be helpful.

      Discussion:

      1) Were there any neural differences between the narrative vs argument scrambled-texts? This might reveal any differences in the processing of the scrambled texts for each condition and might help shine light on features of the scrambled argument condition that contributed to the overall lack of distinction relative to the narrative vs scrambled narrative conditions.

      2) Throughout the results from ISC and ISFC findings are convolved with the findings from univariate or GLM results from prior studies. Please compare and contrast how ISC and ISFC findings might relate to univariate or GLM findings early in the discussion.

      3) Related to point 2 in the introduction, please also cite studies from autobiographical memory retrieval studies that also show the frontoparietal control system working as information is iteratively accumulated and updated over long temporal windows (St. Jacques et al., 2011; Inman et al., 2018; Daselaar et al., 2008).

      4) Please reconsider how the ISC findings are discussed as 'activation'. While the BOLD activity of these areas are certainly coordinated across participants at similar points in the text, I feel like the term activation fits best with studies that convolve the brain activity with an HRF. In particular, from what I understand ISC, a common decrease in BOLD activity across participants at the same time in a read text would also lead to activity or 'activation' of that area in an ISC analysis. This seems counterintuitive. The 2nd paragraph of the discussion describes ISC and ISFC well in terms of what it shows across a sample (synchronization of fluctuations in BOLD activity across participants for the same stimuli). "Activity" may capture this, but please consider some more nuanced ways to refer to these ISC and ISFC findings.

      Figures:

      1) Please double check the box plots in figure 1a for Scene Construction. Another method of displaying this likert rating data might be helpful. While appreciating the attempt to display the individual data points, the simple main points get somewhat obscured by all of the information in the graph.

      2) Overall, I appreciate the attention to detail in all of the figures and the completeness of the data visualization with several useful supplemental figures.

    1. Now one thousand feet away. Now seven hundred. In the best-case scenario, the fire chief told them, people need only close their windows, turn off their AC, and shelter in place. In the worst-case scenario, there is nuclear fallout. A disaster is coming, they realized. And worse than that: nothing is standing in its way.

      This was really impactful for me as a reader because my mother is from missouri and this is still something I have never heard of. The investigative reporting done by two mothers shows the power of the people! What blows me away is the community would have never been warned about such outcomes if there women didn't seek out the truth. There could be a necular fallout and i'm on the edge of my seat reading to what is coming next...

    1. dark windows that showed the stars

      I appreciate the utilization of contrasting ideas in Mansfield’s writing. Here, “stars” and “dark” seem to reflect images of happiness and sadness that perhaps would recur in the later scenes.

    1. ContentsPodcast Recording Software For macOSGarageBandLogic ProPodcast Recording Software For Windows & macOSAdobe AuditionAudacityHindenburg JournalistOther Audio Editing SoftwareHelpful Podcast SoftwareBuzzsproutAlituSquadcastWavveEcamm Call Recorder For SkypeAuphonicMusic Radio CreativeScribie

      Podcast recording software

  3. Oct 2020
    1. I have downloaded this browser, to use with Office 365 (for my Uni stuff). I haven't really given it a full workout yet, mostly as I generally use Brave.

      I personally think we'll see more Microsoft apps coming to Linux with the big one being the ultimate... basing Windows on a Linux Kernel, rather than the NT Kernel, within the next 5 year or so!

    1. Reviewer #3:

      The authors ask whether and how information about an upcoming choice is encoded by neuronal activities in V1. To address this question, they recorded from multiple neurons in V1 simultaneously, while monkeys performed a delayed orientation-match-to-sample task. They then asked whether and how they could decode the stimulus presented to the animal, and/or the upcoming behavioral report of their decision (choice), from these V1 recordings. They found that the combination stimulus+choice could be decoded, and that bursty neurons were most likely to affect the decoded choice. Moreover, neurons in the superficial cortical layer also appeared to have a stronger choice signal. This suggests that the choice signal may arise outside of V1, but nevertheless be reflected by spiking activity within V1.

      This study addresses an interesting and potentially important question: where do choice signals arise in the brain, and how do V1 activities relate to those choice signals? At the same time, I was quite confused about a lot of the data presented and overall remain somewhat unconvinced. My specific critiques are as follows:

      1) In Fig. 1BC: what are these population vectors? In the case of "C", I assume these are the SVM weights that are used to discriminate between choices, and the data for each choice are pooled over both stimulus types (match or non-match). But for "S+C", I don't quite follow what is going on. Is it the case that you do the decoding just on the "correct" trials (as suggested in Table 1)? This critique should highlight the fact that I failed to understand your main point, about decoding C vs "S+C". Much more writing clarity throughout the paper would help with this, and make it possible for me to evaluate the paper's main claims.

      2) Fig. 1D is claimed to tell us how neurons respond differently under different conditions, but it does not do that. It tells us how SVM decoders weight those neurons differently under different conditions. Moreover the result seems kind of trivial: it shows that "strong weights change more" between conditions. That's not very surprising: you are subtracting bigger numbers when there are stronger weights, so the differences will be larger. Is there more going on here?

      3) In Fig. 2: what time intervals were the spikes summed for the decoding? There are some values given for different window lengths, but when did those windows start? Was it at the start of the "test" image presentation? Or some other time?

      4) It seems like movement is a confound. The claim is that choice is represented in V1. But we know from recent work by Stringer et al. (Science 2019), that movement profoundly affects V1 spiking. So if any movement signals precede the behavioural report, those will correlate with choice and be reflected by V1 spiking. In that case, is it really fair to say that V1 encodes choice? Or, rather, that the pre-report motion of the animal is encoded in V1?

      5) I couldn't find strong support for the claim that decoding is better when using superficial neurons vs. deeper ones. A panel like Fig. 7E (which does this for bursty vs non-bursty neurons) but comparing the different layers would help with this. I realize this result is somewhat implied by the differences in bursty neuron fraction across layers (which is shown), but this claim is central and so should be explicitly tested.

      6) I have concerns about a lot of the statistical tests used in this paper. For example:

      a) Fig. 2D. Should do a permutation test, to randomly assign neurons to "big" vs "small" weight categories, then redo the analysis. That will get p-value much more reliably than the t-test, which assumes (incorrectly that data are Gaussian). Another big issue is that the selection of small vs big can have some biasing effects, so the t-test between the two groups could way overemphasize significance. A permutation test is harder to fool in this way.

      b) Fig 3D statistical test compares the analysis of data with optimized weights to a case of random weights and random permutation. That's not quite fair because you optimize the weights for the real data but not for the null hypothesis you are testing. A better test would be to do random permutations of the data, then train the weights on each random permutation and test on held-out data from that random permutation. It will likely yield similar results to what you've got, but be a more compelling test in my opinion.

      c) Fig. 6B: not sure t-test is right. Are these data Gaussian?

      7) The results in Fig. 9BC seem interesting, but it's hard to parse the network diagrams. Showing 3x3 matrices for the CCM coefficients from neurons each layer to ones in each other layer would help me to evaluate the claim that the superficial layer acts as a hub.

    1. “It should be remembered that a picture—before being a warhorse, a nude, or an anecdote of some sort—is essentially a flat surface covered with colours assembled in a certain order.”1A picture, modern art says, is not a windowbut a picture.

      Paintings that function as windows onto another world can be very enjoyable...Why should this be remembered? Why "should"?

    1. Rising states tend to define their interests more expansively as their power increases, and big shifts in the balance of power typically create windows of opportunity and sometimes increase incentives for preventive war.

      Walt's commentary that rising states will seek to capitalize on "big shifts in the balance of power" indicates that the current great powers are defined by their status after wars. Furthermore, Wa't refers to "preventative war" to inhibit a rising power from upsetting the current hierarchy.

    1. Georgia pines flew past the windows of the Greyhound bus carrying Isaac Woodard home to Winnsboro, S.C. After serving four years in the Army in World War II, where Woodard had earned a battle star, he was given an honorable discharge ear-lier that day at Camp Gordon

      Hannah-Jones introduces the story of Issac Woodward to demonstrate that during world war 2 a black man could fight for his country and its freedom just to come home and be discriminated against because of the color of his skin.

    1. free education for all children from 3 years to 6 years of age.This connectedwith the existingfree public education for children from theage of 6 to 18. In 1971 a national law established infant/toddler centers for children from 3 months to 3 years of age.

      Would love to see the US move in this direction. I was also thinking about Reggio schools location. They're often in city center and accessible to the public in some way or form. Is that even possible in the US with such an unfortunate gun problem? I know that when I've worked at Jewish schools the idea was to always hide our windows, block access to the public, and protect our students from an active shooter situation. I wish and long for a time when this is not the case.

    1. Declarative programming is an enabler of abstraction. Imperative programming is an inhibitor of abstraction. Declarative programming allows you to say “I want this and I don’t care how I get it” while imperative programming requires you to define each and every step.

      Declarative programming, i.e. "build me a house, I don't care how", is an enabler of abstraction.

      Imperative programming, i.e. "build walls, windows, a roof.", is an inhibitor of abstraction.

    1. Reviewer #3:

      This is a manuscript by Karimi-Rouzbahani et al, about the neural encoding of facial familiarity using EEG and MVPA.

      I essentially found the article interesting, clear and using solid methods. Besides a few minor comments, which I list below, I found only one major issue which has to be addressed.

      Major comment:

      My only major problem with the results lies in the simple interpretation of anterior contributions to the encoding of familiarity as feed-back. You find, using a clever partialling out method, that eliminating the occipital contributions from the frontal (or rather anterior, as it involves temporal cortex too) electrode pattern familiarity decoding reduces stronger and earlier-longer information encoding about familiarity, when compared to the opposite, when you partial out the frontal information from that of the occipital/posterior electrode pattern. The former is interpreted as a signal of feed-back, while the opposite as feed-forward information flow. This makes sense but only if the frontal cortex does not play a role, on its own right, in face processing. However, the inferior frontal face area (see e.g. Collins and Olson,2014) is known to be associated with the STS and playing a role in social, dynamic and eye-movement related information processing. If we assume that these tasks are more related to the frontal than to the posterior areas, as for example Duchaine and Yovel, 2015 do, then the results of the partialling out analysis merely mean that the functions of the frontal areas are modulated more by the posterior areas (in other words, in those functions the parietal areas also play a role) than the other way around. The lower-level functions of the posterior sites are, on the other hand, modulated less, shorter, later by the removal of frontal areas, in other words the frontal cortexes do not play much role in them.

      This is different from your conclusion where you state feed-forward vs feed-back connections. I don't see any good way to come around this alternative (and simpler) conclusion than your assumption about connectivity. Time would be a potential factor to resolve it, feed-back being later, but in your figures it is clear that the two periods overlap entirely and the peaks also almost fall into identical windows.

      Unless I overlooked something and you can give a convincing way to exclude this possibility I would recommend a) discuss this in the paper and b) tune down your respective conclusions throughout the manuscript.

    1. s developed a magical"look" that was supersaturated with mirrors,picture windows, and electric light. Ezra Poundwrote in 1910 that, thanks to electrification, NewYork was "the most bea

      test

    1. first sighting: use of superscripts like this

      I like it. Nice and concise and understandable.

      • s¹  critical
      • s²  important
      • s³  nice to have
      • s⁴  low
      • s⁵  inconvenient

      But in other cases, the abbreviation is quite unclear and ambiguity:

      Like, what does "pr" mean in these cases?

      priority? Doubt it.

      • pr¹  chore
      • pr²  docs
      • pr³  feature
      • pr⁴  fix
      • pr⁵  performance
      • pr⁶  refactor
      • pr⁷  style

      Pull Request? Doubt it. But maybe?


      For axes that are quantifiable, like severity, using a number makes sense. But what benefit is there in including a number in these (platform?) labels?:

      • p¹ ⋅ browser
      • p² ⋅ linux
      • p³ ⋅ mac
      • p⁴ ⋅ windows

      I think this would have been better and clearer (in that fewer people would be like huh? and wonder what it means):

      • platform: browser
      • platform: linux
      • platform: mac
      • platform: windows
    1. Few white persons of either sex, who are calculated for any thing else, are willing to spend their lives and bury their talents in performing mean, servile labor. And such is the horrible idea that I entertain respecting a life of servitude, that if I conceived of there being no possibility of my rising above the condition of a servant, I would gladly hail death as a welcome messenger. O, horrible idea, indeed! to possess noble souls aspiring after high and honorable acquirements, yet confined by the chains of ignorance and poverty to lives of continual drudgery and toil. Neither do I know of any who have enriched themselves by spending their lives as house-domestics, washing windows, shaking carpets, brushing boots, or tending upon gentlemen’s tables. I can but die for expressing my sentiments; and I am as willing to die by the sword as the pestilence; for I and a true born American; your blood flows in my veins, and your spirit fires my breast.

      I think this paragraph is really powerful and is a nice summary of who Stewart really was and what she stood for. In this paragraph, she discusses how no body wants to spend their life confined to servitude, but that she can see herself living a separate life, where she is living free. Clearly, she wants this aspect of society to be reformed. If black people were to be free'd and left to live life as a normal American, then Stewert's dream of a democracy is met a little closer.

    1. Reserved Strings

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      general category Cf (in Unicode 8.0.0).

      The next line may appear to be blank or mojibake in some viewers.

      ­؀؁؂؃؄؅؜۝܏᠎​‌‍‎‏‪‫‬‭‮⁠⁡⁢⁣⁤⁦⁧⁨⁩𑂽𛲠𛲡𛲢𛲣𝅳𝅴𝅵𝅶𝅷𝅸𝅹𝅺󠀁󠀠󠀡󠀢󠀣󠀤󠀥󠀦󠀧󠀨󠀩󠀪󠀫󠀬󠀭󠀮󠀯󠀰󠀱󠀲󠀳󠀴󠀵󠀶󠀷󠀸󠀹󠀺󠀻󠀼󠀽󠀾󠀿󠁀󠁁󠁂󠁃󠁄󠁅󠁆󠁇󠁈󠁉󠁊󠁋󠁌󠁍󠁎󠁏󠁐󠁑󠁒󠁓󠁔󠁕󠁖󠁗󠁘󠁙󠁚󠁛󠁜󠁝󠁞󠁟󠁠󠁡󠁢󠁣󠁤󠁥󠁦󠁧󠁨󠁩󠁪󠁫󠁬󠁭󠁮󠁯󠁰󠁱󠁲󠁳󠁴󠁵󠁶󠁷󠁸󠁹󠁺󠁻󠁼󠁽󠁾󠁿

      "Byte order marks", U+FEFF and U+FFFE, each on its own line.

      The next two lines may appear to be blank or mojibake in some viewers.

       ￾

      Unicode Symbols

      #

      Strings which contain common unicode symbols (e.g. smart quotes)

      Ω≈ç√∫˜µ≤≥÷ åß∂ƒ©˙∆˚¬…æ œ∑´®†¥¨ˆøπ“‘ ¡™£¢∞§¶•ªº–≠ ¸˛Ç◊ı˜Â¯˘¿ ÅÍÎÏ˝ÓÔÒÚÆ☃ Œ„´‰ˇÁ¨ˆØ∏”’ `⁄€‹›fifl‡°·‚—± ⅛⅜⅝⅞ ЁЂЃЄЅІЇЈЉЊЋЌЍЎЏАБВГДЕЖЗИЙКЛМНОПРСТУФХЦЧШЩЪЫЬЭЮЯабвгдежзийклмнопрстуфхцчшщъыьэюя ٠١٢٣٤٥٦٧٨٩

      Unicode Subscript/Superscript/Accents

      #

      Strings which contain unicode subscripts/superscripts; can cause rendering issues

      ⁰⁴⁵ ₀₁₂ ⁰⁴⁵₀₁₂ ด้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็ ด้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็ ด้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็็้้้้้้้้็็็็็้้้้้็็็็

      Quotation Marks

      #

      Strings which contain misplaced quotation marks; can cause encoding errors

      ' " '' "" '"' "''''"'" "'"'"''''"

      <foo val=“bar” />

      <foo val=“bar” />

      <foo val=”bar“ />

      <foo val=`bar' />

      Two-Byte Characters

      #

      Strings which contain two-byte characters: can cause rendering issues or character-length issues

      田中さんにあげて下さい パーティーへ行かないか 和製漢語 部落格 사회과학원 어학연구소 찦차를 타고 온 펲시맨과 쑛다리 똠방각하 社會科學院語學研究所 울란바토르 𠜎𠜱𠝹𠱓𠱸𠲖𠳏

      Strings which contain two-byte letters: can cause issues with naïve UTF-16 capitalizers which think that 16 bits == 1 character

      𐐜 𐐔𐐇𐐝𐐀𐐡𐐇𐐓 𐐙𐐊𐐡𐐝𐐓/𐐝𐐇𐐗𐐊𐐤𐐔 𐐒𐐋𐐗 𐐒𐐌 𐐜 𐐡𐐀𐐖𐐇𐐤𐐓𐐝 𐐱𐑂 𐑄 𐐔𐐇𐐝𐐀𐐡𐐇𐐓 𐐏𐐆𐐅𐐤𐐆𐐚𐐊𐐡𐐝𐐆𐐓𐐆

      Special Unicode Characters Union

      #

      A super string recommended by VMware Inc. Globalization Team: can effectively cause rendering issues or character-length issues to validate product globalization readiness.

      #

      表 CJK_UNIFIED_IDEOGRAPHS (U+8868)

      ポ KATAKANA LETTER PO (U+30DD)

      あ HIRAGANA LETTER A (U+3042)

      A LATIN CAPITAL LETTER A (U+0041)

      鷗 CJK_UNIFIED_IDEOGRAPHS (U+9DD7)

      Œ LATIN SMALL LIGATURE OE (U+0153)

      é LATIN SMALL LETTER E WITH ACUTE (U+00E9)

      B FULLWIDTH LATIN CAPITAL LETTER B (U+FF22)

      逍 CJK_UNIFIED_IDEOGRAPHS (U+900D)

      Ü LATIN SMALL LETTER U WITH DIAERESIS (U+00FC)

      ß LATIN SMALL LETTER SHARP S (U+00DF)

      ª FEMININE ORDINAL INDICATOR (U+00AA)

      ą LATIN SMALL LETTER A WITH OGONEK (U+0105)

      ñ LATIN SMALL LETTER N WITH TILDE (U+00F1)

      丂 CJK_UNIFIED_IDEOGRAPHS (U+4E02)

      㐀 CJK Ideograph Extension A, First (U+3400)

      𠀀 CJK Ideograph Extension B, First (U+20000)

      表ポあA鷗ŒéB逍Üߪąñ丂㐀𠀀

      Changing length when lowercased

      #

      Characters which increase in length (2 to 3 bytes) when lowercased

      Credit: https://twitter.com/jifa/status/625776454479970304

      Ⱥ Ⱦ

      Japanese Emoticons

      #

      Strings which consists of Japanese-style emoticons which are popular on the web

      ヽ༼ຈل͜ຈ༽ノ ヽ༼ຈل͜ຈ༽ノ (。◕ ∀ ◕。) `ィ(´∀`∩ _ロ(,,) ・( ̄∀ ̄)・:: ゚・✿ヾ╲(。◕‿◕。)╱✿・゚ ,。・::・゜’( ☻ ω ☻ )。・::・゜’ (╯°□°)╯︵ ┻━┻) (ノಥ益ಥ)ノ ┻━┻ ┬─┬ノ( º ºノ) ( ͡° ͜ʖ ͡°) ¯\(ツ)_/¯

      Emoji

      #

      Strings which contain Emoji; should be the same behavior as two-byte characters, but not always

      😍 👩🏽 👨‍🦰 👨🏿‍🦰 👨‍🦱 👨🏿‍🦱 🦹🏿‍♂️ 👾 🙇 💁 🙅 🙆 🙋 🙎 🙍 🐵 🙈 🙉 🙊 ❤️ 💔 💌 💕 💞 💓 💗 💖 💘 💝 💟 💜 💛 💚 💙 ✋🏿 💪🏿 👐🏿 🙌🏿 👏🏿 🙏🏿 👨‍👩‍👦 👨‍👩‍👧‍👦 👨‍👨‍👦 👩‍👩‍👧 👨‍👦 👨‍👧‍👦 👩‍👦 👩‍👧‍👦 🚾 🆒 🆓 🆕 🆖 🆗 🆙 🏧 0️⃣ 1️⃣ 2️⃣ 3️⃣ 4️⃣ 5️⃣ 6️⃣ 7️⃣ 8️⃣ 9️⃣ 🔟

      Regional Indicator Symbols

      #

      Regional Indicator Symbols can be displayed differently across

      fonts, and have a number of special behaviors

      🇺🇸🇷🇺🇸 🇦🇫🇦🇲🇸 🇺🇸🇷🇺🇸🇦🇫🇦🇲 🇺🇸🇷🇺🇸🇦

      Unicode Numbers

      #

      Strings which contain unicode numbers; if the code is localized, it should see the input as numeric

      123 ١٢٣

      Right-To-Left Strings

      #

      Strings which contain text that should be rendered RTL if possible (e.g. Arabic, Hebrew)

      ثم نفس سقطت وبالتحديد،, جزيرتي باستخدام أن دنو. إذ هنا؟ الستار وتنصيب كان. أهّل ايطاليا، بريطانيا-فرنسا قد أخذ. سليمان، إتفاقية بين ما, يذكر الحدود أي بعد, معاملة بولندا، الإطلاق عل إيو. בְּרֵאשִׁית, בָּרָא אֱלֹהִים, אֵת הַשָּׁמַיִם, וְאֵת הָאָרֶץ הָיְתָהtestالصفحات التّحول ﷽ ﷺ مُنَاقَشَةُ سُبُلِ اِسْتِخْدَامِ اللُّغَةِ فِي النُّظُمِ الْقَائِمَةِ وَفِيم يَخُصَّ التَّطْبِيقَاتُ الْحاسُوبِيَّةُ، الكل في المجمو عة (5)

      Ogham Text

      #

      The only unicode alphabet to use a space which isn't empty but should still act like a space.

      ᚛ᚄᚓᚐᚋᚒᚄ ᚑᚄᚂᚑᚏᚅ᚜ ᚛                 ᚜

      Trick Unicode

      #

      Strings which contain unicode with unusual properties (e.g. Right-to-left override) (c.f. http://www.unicode.org/charts/PDF/U2000.pdf)

      ‪‪test‪ ‫test‫ 
test
 test⁠test‫ ⁦test⁧

      Zalgo Text

      #

      Strings which contain "corrupted" text. The corruption will not appear in non-HTML text, however. (via http://www.eeemo.net)

      Ṱ̺̺̕o͞ ̷i̲̬͇̪͙n̝̗͕v̟̜̘̦͟o̶̙̰̠kè͚̮̺̪̹̱̤ ̖t̝͕̳̣̻̪͞h̼͓̲̦̳̘̲e͇̣̰̦̬͎ ̢̼̻̱̘h͚͎͙̜̣̲ͅi̦̲̣̰̤v̻͍e̺̭̳̪̰-m̢iͅn̖̺̞̲̯̰d̵̼̟͙̩̼̘̳ ̞̥̱̳̭r̛̗̘e͙p͠r̼̞̻̭̗e̺̠̣͟s̘͇̳͍̝͉e͉̥̯̞̲͚̬͜ǹ̬͎͎̟̖͇̤t͍̬̤͓̼̭͘ͅi̪̱n͠g̴͉ ͏͉ͅc̬̟h͡a̫̻̯͘o̫̟̖͍̙̝͉s̗̦̲.̨̹͈̣ ̡͓̞ͅI̗̘̦͝n͇͇͙v̮̫ok̲̫̙͈i̖͙̭̹̠̞n̡̻̮̣̺g̲͈͙̭͙̬͎ ̰t͔̦h̞̲e̢̤ ͍̬̲͖f̴̘͕̣è͖ẹ̥̩l͖͔͚i͓͚̦͠n͖͍̗͓̳̮g͍ ̨o͚̪͡f̘̣̬ ̖̘͖̟͙̮c҉͔̫͖͓͇͖ͅh̵̤̣͚͔á̗̼͕ͅo̼̣̥s̱͈̺̖̦̻͢.̛̖̞̠̫̰ ̗̺͖̹̯͓Ṯ̤͍̥͇͈h̲́e͏͓̼̗̙̼̣͔ ͇̜̱̠͓͍ͅN͕͠e̗̱z̘̝̜̺͙p̤̺̹͍̯͚e̠̻̠͜r̨̤͍̺̖͔̖̖d̠̟̭̬̝͟i̦͖̩͓͔̤a̠̗̬͉̙n͚͜ ̻̞̰͚ͅh̵͉i̳̞v̢͇ḙ͎͟-҉̭̩̼͔m̤̭̫i͕͇̝̦n̗͙ḍ̟ ̯̲͕͞ǫ̟̯̰̲͙̻̝f ̪̰̰̗̖̭̘͘c̦͍̲̞͍̩̙ḥ͚a̮͎̟̙͜ơ̩̹͎s̤.̝̝ ҉Z̡̖̜͖̰̣͉̜a͖̰͙̬͡l̲̫̳͍̩g̡̟̼̱͚̞̬ͅo̗͜.̟ ̦H̬̤̗̤͝e͜ ̜̥̝̻͍̟́w̕h̖̯͓o̝͙̖͎̱̮ ҉̺̙̞̟͈W̷̼̭a̺̪͍į͈͕̭͙̯̜t̶̼̮s̘͙͖̕ ̠̫̠B̻͍͙͉̳ͅe̵h̵̬͇̫͙i̹͓̳̳̮͎̫̕n͟d̴̪̜̖ ̰͉̩͇͙̲͞ͅT͖̼͓̪͢h͏͓̮̻e̬̝̟ͅ ̤̹̝W͙̞̝͔͇͝ͅa͏͓͔̹̼̣l̴͔̰̤̟͔ḽ̫.͕ Z̮̞̠͙͔ͅḀ̗̞͈̻̗Ḷ͙͎̯̹̞͓G̻O̭̗̮

      Unicode Upsidedown

      #

      Strings which contain unicode with an "upsidedown" effect (via http://www.upsidedowntext.com)

      ˙ɐnbᴉlɐ ɐuƃɐɯ ǝɹolop ʇǝ ǝɹoqɐl ʇn ʇunpᴉpᴉɔuᴉ ɹodɯǝʇ poɯsnᴉǝ op pǝs 'ʇᴉlǝ ƃuᴉɔsᴉdᴉpɐ ɹnʇǝʇɔǝsuoɔ 'ʇǝɯɐ ʇᴉs ɹolop ɯnsdᴉ ɯǝɹo˥ 00˙Ɩ$-

      Unicode font

      #

      Strings which contain bold/italic/etc. versions of normal characters

      The quick brown fox jumps over the lazy dog 𝐓𝐡𝐞 𝐪𝐮𝐢𝐜𝐤 𝐛𝐫𝐨𝐰𝐧 𝐟𝐨𝐱 𝐣𝐮𝐦𝐩𝐬 𝐨𝐯𝐞𝐫 𝐭𝐡𝐞 𝐥𝐚𝐳𝐲 𝐝𝐨𝐠 𝕿𝖍𝖊 𝖖𝖚𝖎𝖈𝖐 𝖇𝖗𝖔𝖜𝖓 𝖋𝖔𝖝 𝖏𝖚𝖒𝖕𝖘 𝖔𝖛𝖊𝖗 𝖙𝖍𝖊 𝖑𝖆𝖟𝖞 𝖉𝖔𝖌 𝑻𝒉𝒆 𝒒𝒖𝒊𝒄𝒌 𝒃𝒓𝒐𝒘𝒏 𝒇𝒐𝒙 𝒋𝒖𝒎𝒑𝒔 𝒐𝒗𝒆𝒓 𝒕𝒉𝒆 𝒍𝒂𝒛𝒚 𝒅𝒐𝒈 𝓣𝓱𝓮 𝓺𝓾𝓲𝓬𝓴 𝓫𝓻𝓸𝔀𝓷 𝓯𝓸𝔁 𝓳𝓾𝓶𝓹𝓼 𝓸𝓿𝓮𝓻 𝓽𝓱𝓮 𝓵𝓪𝔃𝔂 𝓭𝓸𝓰 𝕋𝕙𝕖 𝕢𝕦𝕚𝕔𝕜 𝕓𝕣𝕠𝕨𝕟 𝕗𝕠𝕩 𝕛𝕦𝕞𝕡𝕤 𝕠𝕧𝕖𝕣 𝕥𝕙𝕖 𝕝𝕒𝕫𝕪 𝕕𝕠𝕘 𝚃𝚑𝚎 𝚚𝚞𝚒𝚌𝚔 𝚋𝚛𝚘𝚠𝚗 𝚏𝚘𝚡 𝚓𝚞𝚖𝚙𝚜 𝚘𝚟𝚎𝚛 𝚝𝚑𝚎 𝚕𝚊𝚣𝚢 𝚍𝚘𝚐 ⒯⒣⒠ ⒬⒰⒤⒞⒦ ⒝⒭⒪⒲⒩ ⒡⒪⒳ ⒥⒰⒨⒫⒮ ⒪⒱⒠⒭ ⒯⒣⒠ ⒧⒜⒵⒴ ⒟⒪⒢

      Script Injection

      #

      Strings which attempt to invoke a benign script injection; shows vulnerability to XSS

      <script>alert(123)</script> <script>alert('123');</script> <svg><script>123<1>alert(123)</script> "><script>alert(123)</script> '><script>alert(123)</script> ><script>alert(123)</script> </script><script>alert(123)</script> < / script >< script >alert(123)< / script > onfocus=JaVaSCript:alert(123) autofocus " onfocus=JaVaSCript:alert(123) autofocus ' onfocus=JaVaSCript:alert(123) autofocus <script>alert(123)</script> <sc<script>ript>alert(123)</sc</script>ript> --><script>alert(123)</script> ";alert(123);t=" ';alert(123);t=' JavaSCript:alert(123) ;alert(123); src=JaVaSCript:prompt(132) "><script>alert(123);</script x=" '><script>alert(123);</script x=' ><script>alert(123);</script x= " autofocus onkeyup="javascript:alert(123) ' autofocus onkeyup='javascript:alert(123) <script\x20type="text/javascript">javascript:alert(1);</script> <script\x3Etype="text/javascript">javascript:alert(1);</script> <script\x0Dtype="text/javascript">javascript:alert(1);</script> <script\x09type="text/javascript">javascript:alert(1);</script> <script\x0Ctype="text/javascript">javascript:alert(1);</script> <script\x2Ftype="text/javascript">javascript:alert(1);</script> <script\x0Atype="text/javascript">javascript:alert(1);</script> '`"><\x3Cscript>javascript:alert(1)</script> '`"><\x00script>javascript:alert(1)</script> ABC<div style="x\x3Aexpression(javascript:alert(1)">DEF ABC<div style="x:expression\x5C(javascript:alert(1)">DEF ABC<div style="x:expression\x00(javascript:alert(1)">DEF ABC<div style="x:exp\x00ression(javascript:alert(1)">DEF ABC<div style="x:exp\x5Cression(javascript:alert(1)">DEF ABC<div style="x:\x0Aexpression(javascript:alert(1)">DEF ABC<div style="x:\x09expression(javascript:alert(1)">DEF ABC<div style="x:\xE3\x80\x80expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x84expression(javascript:alert(1)">DEF ABC<div style="x:\xC2\xA0expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x80expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x8Aexpression(javascript:alert(1)">DEF ABC<div style="x:\x0Dexpression(javascript:alert(1)">DEF ABC<div style="x:\x0Cexpression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x87expression(javascript:alert(1)">DEF ABC<div style="x:\xEF\xBB\xBFexpression(javascript:alert(1)">DEF ABC<div style="x:\x20expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x88expression(javascript:alert(1)">DEF ABC<div style="x:\x00expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x8Bexpression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x86expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x85expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x82expression(javascript:alert(1)">DEF ABC<div style="x:\x0Bexpression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x81expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x83expression(javascript:alert(1)">DEF ABC<div style="x:\xE2\x80\x89expression(javascript:alert(1)">DEF test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test test `"'> `"'> `"'> `"'> `"'> `"'> `"'> `"'> `"'> `"'> "`'><script>\x3Bjavascript:alert(1)</script> "`'><script>\x0Djavascript:alert(1)</script> "`'><script>\xEF\xBB\xBFjavascript:alert(1)</script> "`'><script>\xE2\x80\x81javascript:alert(1)</script> "`'><script>\xE2\x80\x84javascript:alert(1)</script> "`'><script>\xE3\x80\x80javascript:alert(1)</script> "`'><script>\x09javascript:alert(1)</script> "`'><script>\xE2\x80\x89javascript:alert(1)</script> "`'><script>\xE2\x80\x85javascript:alert(1)</script> "`'><script>\xE2\x80\x88javascript:alert(1)</script> "`'><script>\x00javascript:alert(1)</script> "`'><script>\xE2\x80\xA8javascript:alert(1)</script> "`'><script>\xE2\x80\x8Ajavascript:alert(1)</script> "`'><script>\xE1\x9A\x80javascript:alert(1)</script> "`'><script>\x0Cjavascript:alert(1)</script> "`'><script>\x2Bjavascript:alert(1)</script> "`'><script>\xF0\x90\x96\x9Ajavascript:alert(1)</script> "`'><script>-javascript:alert(1)</script> "`'><script>\x0Ajavascript:alert(1)</script> "`'><script>\xE2\x80\xAFjavascript:alert(1)</script> "`'><script>\x7Ejavascript:alert(1)</script> "`'><script>\xE2\x80\x87javascript:alert(1)</script> "`'><script>\xE2\x81\x9Fjavascript:alert(1)</script> "`'><script>\xE2\x80\xA9javascript:alert(1)</script> "`'><script>\xC2\x85javascript:alert(1)</script> "`'><script>\xEF\xBF\xAEjavascript:alert(1)</script> "`'><script>\xE2\x80\x83javascript:alert(1)</script> "`'><script>\xE2\x80\x8Bjavascript:alert(1)</script> "`'><script>\xEF\xBF\xBEjavascript:alert(1)</script> "`'><script>\xE2\x80\x80javascript:alert(1)</script> "`'><script>\x21javascript:alert(1)</script> "`'><script>\xE2\x80\x82javascript:alert(1)</script> "`'><script>\xE2\x80\x86javascript:alert(1)</script> "`'><script>\xE1\xA0\x8Ejavascript:alert(1)</script> "`'><script>\x0Bjavascript:alert(1)</script> "`'><script>\x20javascript:alert(1)</script> "`'><script>\xC2\xA0javascript:alert(1)</script> <img\x47src=x onerror="javascript:alert(1)"> <img\x10src=x onerror="javascript:alert(1)"> <img\x13src=x onerror="javascript:alert(1)"> <img\x32src=x onerror="javascript:alert(1)"> <img\x47src=x onerror="javascript:alert(1)"> <img\x11src=x onerror="javascript:alert(1)"> <img[a][b][c]src[d]=x[e]onerror=[f]"alert(1)"> XXX <title onpropertychange=javascript:alert(1)></title><title title=> `><img src=x:x onerror=javascript:alert(1)></a> <script src="/\%(jscript)s"></script> <script src="\\%(jscript)s"></script> <SCRIPT>alert("XSS")</SCRIPT>"> perl -e 'print "";' > out <SCRIPT/XSS SRC="http://ha.ckers.org/xss.js"></SCRIPT> <BODY onload!#$%&()*~+-_.,:;?@[/|\]^`=alert("XSS")> <SCRIPT/SRC="http://ha.ckers.org/xss.js"></SCRIPT> <<SCRIPT>alert("XSS");//<</SCRIPT> <SCRIPT SRC=http://ha.ckers.org/xss.js?< B > <SCRIPT SRC=//ha.ckers.org/.j> Copy me</u> Scroll over me <plaintext> http://a/%%30%30 </textarea><script>alert(123)</script>

      SQL Injection

      #

      Strings which can cause a SQL injection if inputs are not sanitized

      1;DROP TABLE users 1'; DROP TABLE users-- 1 ' OR 1=1 -- 1 ' OR '1'='1 '; EXEC sp_MSForEachTable 'DROP TABLE ?'; --

      % _

      Server Code Injection

      #

      Strings which can cause user to run code on server as a privileged user (c.f. https://news.ycombinator.com/item?id=7665153)

      -

      --version --help $USER /dev/null; touch /tmp/blns.fail ; echo touch /tmp/blns.fail $(touch /tmp/blns.fail) @{[system "touch /tmp/blns.fail"]}

      Command Injection (Ruby)

      #

      Strings which can call system commands within Ruby/Rails applications

      eval("puts 'hello world'") System("ls -al /") ls -al / Kernel.exec("ls -al /") Kernel.exit(1) %x('ls -al /')

      XXE Injection (XML)

      #

      String which can reveal system files when parsed by a badly configured XML parser

      <?xml version="1.0" encoding="ISO-8859-1"?><!DOCTYPE foo [ <!ELEMENT foo ANY ><!ENTITY xxe SYSTEM "file:///etc/passwd" >]><foo>&xx;;</foo>

      Unwanted Interpolation

      #

      Strings which can be accidentally expanded into different strings if evaluated in the wrong context, e.g. used as a printf format string or via Perl or shell eval. Might expose sensitive data from the program doing the interpolation, or might just represent the wrong string.

      $HOME $ENV{'HOME'} %d %s%s%s%s%s {0} %.s %@ %n File:///

      File Inclusion

      #

      Strings which can cause user to pull in files that should not be a part of a web server

      ../../../../../../../../../../../etc/passwd%00 ../../../../../../../../../../../etc/hosts

      Known CVEs and Vulnerabilities

      #

      Strings that test for known vulnerabilities

      () { 0; }; touch /tmp/blns.shellshock1.fail; () { ; } >[$($())] { touch /tmp/blns.shellshock2.fail; } <<< %s(un='%s') = %u +++ATH0

      MSDOS/Windows Special Filenames

      #

      Strings which are reserved characters in MSDOS/Windows

      CON PRN AUX CLOCK$ NUL A: ZZ: COM1 LPT1 LPT2 LPT3 COM2 COM3 COM4

      IRC specific strings

      #

      Strings that may occur on IRC clients that make security products freak out

      DCC SEND STARTKEYLOGGER 0 0 0

      Scunthorpe Problem

      #

      Innocuous strings which may be blocked by profanity filters (https://en.wikipedia.org/wiki/Scunthorpe_problem)

      Scunthorpe General Hospital Penistone Community Church Lightwater Country Park Jimmy Clitheroe Horniman Museum shitake mushrooms RomansInSussex.co.uk http://www.cum.qc.ca/ Craig Cockburn, Software Specialist Linda Callahan Dr. Herman I. Libshitz magna cum laude Super Bowl XXX medieval erection of parapets evaluate mocha expression Arsenal canal classic Tyson Gay Dick Van Dyke basement

      Human injection

      #

      Strings which may cause human to reinterpret worldview

      If you're reading this, you've been in a coma for almost 20 years now. We're trying a new technique. We don't know where this message will end up in your dream, but we hope it works. Please wake up, we miss you.

      Terminal escape codes

      #

      Strings which punish the fools who use cat/type on this file

      Roses are ?[0;31mred?[0m, violets are ?[0;34mblue. Hope you enjoy terminal hue But now...?[20Cfor my greatest trick...?[8m The quic??????k brown fo???????????x... [Beeeep]

      iOS Vulnerabilities

      #

      Strings which crashed iMessage in various versions of iOS

      Powerلُلُصّبُلُلصّبُررً ॣ ॣh ॣ ॣ冗 🏳0🌈️ జ్ఞ‌ా

      Persian special characters

      #

      This is a four characters string which includes Persian special characters (گچپژ)

      گچپژ

      jinja2 injection

      #

      first one is supposed to raise "MemoryError" exception

      second, obviously, prints contents of /etc/passwd

      {% print 'x' 64 1024**3 %} {{ "".class.mro[2].subclasses()40.read() }}

    1. Gibbs phenomenon

      Truncating the ideal impulse response through windowing creates ripple in pass- and stopbands. This is the "Gibbs phenomenon." Non-rectangular windows alter the ripple.

    1. Zinc sulfide is one of the most important II-VI semiconduc-tor materials due to its distinct electrical and optical proper-ties. Zinc sulfide nanoparticles (ZnS-NPs) with wide bandgap(3.5-3.8 eV) have recently received intensive attention to beused in many applications [1] such as antimicrobial activity[2, 3], electroluminescence devices, photonic devices [4],fieldemission devices [5], sensors [6, 7], and applications in infra-red windows [8] and lasers [9, 10]. A variety of physical andchemical methods have been used to synthesize ZnS-NPssuch as thermal evaporation [11], sputtering [12], spraypyrolysis [13], chemical vapor deposition [14], molecularbeam epitaxy [15], pulsed laser deposition [16], microwave[17, 18], wet chemistry processes [19, 20], sonochemical

      El sulfuro de Zinc es uno de los más importantes materiales semi-conductores II-VI debido a sus distintivas propiedades eléctricas y ópticas. Las nanopartículas del sulfuro de Zinc (ZnS-NPS) con un amplio band gap (3.5-3.8 eV) recientemente han recibido una intensiva atención por ser usadas en muchas aplicaciones [1] tales como actividades anti microbios [2,3], dispositivos electro-lumiscentes, dispositivos fotónicos [4], dispositivos de emisión de campo [5], sensores [6,7] y aplicaciones en ventanas infrarrojas [8] y láseres [9, 10]. Una variedad de métodos químicos y físicos han sido utilizados para sintetizar ZnS-NPS tales como evaporación termal [11], pulverización catódica [12], pirolisis por spray [13], deposición química de vapor [14], Crecimiento epitaxial por haces moleculares [15], la deposición por laser pulsado [16], microondas [17, 18] procesos químicos húmedos [19.20], preparación somóquimica [21], y síntesis verde- Entre los diversos métodos, el baño químico por deposición (CBD) es el más comúnmente usado por su simplicidad, bajo costo y revestimiento de grandes areas del semiconductor con una buena calidad y una alta pureza de películas delgadas. El principal objetivo del presente trabajo es estudiar la influencia del baño de temperatura y el tiempo de deposición en la superficie topográfica y las propiedades ópticas de películas delgadas de ZnS-NP.

    1. Raindrop.io is available as Chrome, Firefox, Safari, and Edge extension.But we also have Web, Windows, Mac, iPad, iPhone, and Android app.

      Raindrop.io is available as Chrome, Firefox, Safari, and Edge extensions. We also have Web, Windows, Mac, iPad, iPhone, and Android apps.

    1. Health officials urged people to stay inside and keep windows and doors closed. Smoke can irritate the eyes and lungs and worsen some medical conditions. Health experts warned that young children, adults over 65, pregnant women and people with heart disease, asthma or other respiratory conditions were especially vulnerable.

      Possible solutions, this argument paper is not a proposal it is more of a position because of this solution.

    1. SciScore for 10.1101/2020.10.12.20211599: (What is this?)

      Please note, not all rigor criteria are appropriate for all manuscripts.

      Table 1: Rigor

      <table><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Institutional Review Board Statement</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Randomization</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Blinding</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Power Analysis</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Sex as a biological variable</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr></table>

      Table 2: Resources

      <table><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Antibodies</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Regarding seasonal coronaviruses, this assay measures IgG antibodies directed against the nucleocapsid protein (NP) of HCoV 229E, NL63, OC43 and HKU1.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>NL63</div> <div>suggested: None</div> </div> <div style="margin-bottom:8px"> <div>HKU1</div> <div>suggested: None</div> </div> </td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">A two-sided p-value of 0.05 was considered significant. 3: a) Correlation of length of stay and OC43 antibody levels.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>OC43</div> <div>suggested: (Abcam Cat# ab28169, RRID:AB_777848)</div> </div> </td></tr><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Software and Algorithms</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">In addition, relative antibody levels were quantitatively determined with ImageJ (version 153, 64bit-Version for windows) [6] using the signal intensity of the cutoff band of individual immunstrips as internal reference.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>ImageJ</div> <div>suggested: (ImageJ, RRID:SCR_003070)</div> </div> </td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Demographical data, type of treatment and length of stay were extracted by the Medical Data Integration Center (MeDIC) from the hospital information system of the University Hospital Münster (ORBIS from Dedalus Healthcare Group).</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>Dedalus Healthcare</div> <div>suggested: None</div> </div> </td></tr></table>

      Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


      Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

      This study has important limitations: It is a retrospective single-site study with a limited number of cases and association is not causation. However, it is remarkable that the effect of HCoV OC43 and HKU1specific antibody levels reached statistical significance regarding the need for intensive care therapy with only 60 patients. Therefore, these findings should be validated in other sites with larger patient collectives. In a prospective setting (e.g. for risk groups with contacts to many persons like employees of hospitals or supermarkets) it should be tested if the absence of HCoV OC43 and HKU1-specific antibody levels can identify persons at risk for a severe course of COVID-19. Identification of vulnerable individuals is a key priority in the current stage of the pandemic to guide protective measures and to design vaccination strategies.


      Results from TrialIdentifier: No clinical trial numbers were referenced.


      Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


      Results from JetFighter: We did not find any issues relating to colormaps.


      About SciScore

      SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

    1. In such buildings, Baer is told, there was no electricity or indoor plumbing, forcing tenants to get their water and use outhouses in a backyard area. The residents of the apartment featured were actually fortunate, in a way, because they had two windows that brought in fresh air and light; many tenement dwellers did not enjoy such "luxuries."

      The people that live in house have more difficulties because does not have electricity, water access inside of the house and use the backyard of the house to get this thing, unlike the people that living in the building have a litter lucky because get light and fresh air from the window.

    2. Apartments now had to follow minimum size requirements, have windows for the flow of light and air, and include indoor gas lighting, toilets, and fire escapes.

      In the 1901 make another law to the Tenement House Act that one apartment has to follow some requirements for people to live there.

    1. high-order bit is 1

      以 scroll lock 實驗 : test begin [ lit hex 91 , ] GetKeyState .q cr 500 Sleep drop again ; 壓著不放就是 FF80 或 FF81 , bit 0 是 toggling.

    1. It’s all subtle and submarine, through colonnades of coral, past the gothic windows of sea-fans to where the crusty grouper, onyx-eyed, blinks, weighted by its jewels, like a bald queen;

      Walcott uses uses the metonym of vibrant and diverse sea life and correlates that to describe the layers blocking a rich history. He is imploring the reader to simply go forth and look past the imposed obscurity to find the vast collection of their treasured past, and not to look for it in the confides of another context such as religion.

    1. Storyspace has an always-visible Toolbar and Menu to aid students. The Toolbar (Figure 2) provides, top-left to right and down: a Writing Space tool (to create writing areas), the Arrow tool (already familiar to Macintosh users) for routine selecting and clicking, the Note tool (the star) for attaching notes to text, and the Navigation tool (double-headed arrow) for creating and following text links. The Magnify tool (three windows) decreases or enlarges the size of windows. The Linking tool (boxes connected by line) enables linking of one text to other text areas. The Tunnel tool (box within a box) permits linking over widely separated writing spaces. The Compass (four directional arrows) is used to move quickly through levels of the chart, outline, or windows.

      The design of this, which predates that of the wiki, also seems eerily familiar as a digital version of a zettelkasten or the design which seems to underlie Roam Research's product.

    1. Side note: After recently seeing Yale Art Gallery’s show “Seriously Funny: Caricature Through the Centuries,” I think there’s a good article to be written about the historical parallels between today’s visual memes and political cartoons from the past.

      This also makes me think back to other entertainments of the historical poor including the use/purpose of stained glass windows in church supposedly as a means of entertaining the illiterate Latin vulgate masses.

    1. python-igraph 0.8.3, the third release the 0.8 series is now available. You can install it from PyPI 1 where we provide precompiled wheels for Python 3.6 to 3.9 on Linux, macOS and Windows. You can find the source code 1 if you want to compile it on your own.
    1. large window sizes will appear like negative windows and TCP will now work (MUST-1).

      "now work" ... is it "not work"?

      Also what does MUST - 1 indicate?

    1. . The morning sunshine tinted the destruction golden. The shards of shattered windows winked in the light. 

      The author juxtaposes the gory, traumatic events to iridescent imagery and pieces of the city. Is this to highlight beauty in a tragedy? To highlight how easy it is too move on and look past crisis?

    2. The morning sunshine tinted the destruction golden. The shards of shattered windows winked in the light. 

      The author uses a lot of imagery to describe the city and situation at hand.

    1. Students need Windows 98 or above and a PC or Macintosh with at least a 56k modem, an Internet service provider, and a web browser

      find the more recent version of this. is it on the COVID page?

    1. Calls back the lovely April of her prime;So thou through windows of thine age shalt see,Despite of wrinkles this thy golden time.

      The young man need only look at his own mother to see how important his youth and beauty are to her, as a constant reminder of "the lovely April of her prime". The poet urges the young man to let another woman experience this joy, by having his children, and he too will benefit from seeing in his child his former "golden time".

    1. the basic input and output system [p. 150] called BIOS

      le BIOS, c’est le système d’exploitation primitif qui permet de démarrer l’ordinateur, avant de démarrer le système d’exploitation principal (ex. Windows, macOS). Il est beaucoup plus couplé au matériel (hardware) que le système d’exploitation principal (interchangeable: Windows8/Windows10, Linux, etc.).

      capture d’écran BIOS

    1. “Broken Windows policing,” a style of policing that led to “the criminalization and over-policing of communities of color” by criminalizingpublic alcohol consumption, jaywalking, spitting, loitering, trespassing, possession of marijuana,and other crimes that do not put the public in danger

      I never heard of this term before.

    1. Why Are Finland’s Schools Successful? The country’s achievements in education have other nations, especially the United States, doing their homework <img src="https://thumbs-prod.si-cdn.com/thzZYTv2Evhq3x8iHdcaakihfVE=/800x600/filters:no_upscale()/https://public-media.si-cdn.com/filer/cd/ee/cdee1c82-f8e3-4de4-983e-8599d4485745/finland-smiles-wr.jpg" alt="Kirkkojarvi School" itemprop="image"> "This is what we do every day," says Kirkkojarvi Comprehensive School principal Kari Louhivuori, "prepare kids for life." (Stuart Conway) By LynNell Hancock Smithsonian Magazine | Subscribe September 2011 AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to RedditReddit78Share to PinterestPinterest997Share to LinkedInLinkedInShare to FlipboardFlipboardShare to EmailEmailShare to PrintPrintShare to MoreAddThis934 It was the end of term at Kirkkojarvi Comprehensive School in Espoo, a sprawling suburb west of Helsinki, when Kari Louhivuori, a veteran teacher and the school’s principal, decided to try something extreme—by Finnish standards. One of his sixth-grade students, a Kosovo-Albanian boy, had drifted far off the learning grid, resisting his teacher’s best efforts. The school’s team of special educators—including a social worker, a nurse and a psychologist—convinced Louhivuori that laziness was not to blame. So he decided to hold the boy back a year, a measure so rare in Finland it’s practically obsolete. function dispatchComscoreLoadedEvent(){ let event = new Event('MPlayerComscoreLoaded'); window.dispatchEvent(event); } !function(e){var t={};function n(r){if(t[r])return t[r].exports;var i=t[r]={i:r,l:!1,exports:{}};return e[r].call(i.exports,i,i.exports,n),i.l=!0,i.exports}n.m=e,n.c=t,n.d=function(e,t,r){n.o(e,t)||Object.defineProperty(e,t,{enumerable:!0,get:r})},n.r=function(e){"undefined"!==typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},n.t=function(e,t){if(1&t&&(e=n(e)),8&t)return e;if(4&t&&"object"===typeof e&&e&&e.__esModule)return e;var r=Object.create(null);if(n.r(r),Object.defineProperty(r,"default",{enumerable:!0,value:e}),2&t&&"string"!=typeof e)for(var i in e)n.d(r,i,function(t){return e[t]}.bind(null,i));return r},n.n=function(e){var t=e&&e.__esModule?function(){return 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google.ima.AdsLoader(t),a.adsLoader.getSettings().setDisableCustomPlaybackForIOS10Plus(!0),a.adsLoader.getSettings().setVpaidMode(google.ima.ImaSdkSettings.VpaidMode[n]),a.adsLoader.addEventListener(google.ima.AdsManagerLoadedEvent.Type.ADS_MANAGER_LOADED,a.onIMAAdsManagerLoaded.bind(a),!1,a),a.adsLoader.addEventListener(google.ima.AdErrorEvent.Type.AD_ERROR,a.onAdError.bind(a),!1,a)}),f()(this,"createAdRequest",function(e){var t=a.store.getState,n=gn.muted(t()),r=bi.adRequestTimeout(t());return Yi.generateAdRequest(e,n,r)}),f()(this,"validateAdRequestCorrectness",function(e){e&&e.adTagUrl&&decodeURIComponent(e.adTagUrl.replace(/\+/g," "))}),f()(this,"getLoadingError",function(e){var t=function(){return"bad ad request ".concat(JSON.stringify(e))};return{getError:function(){return{getMessage:t}}}}),f()(this,"getPlayAdError",function(e){var t=function(){return"play ad error: ".concat(JSON.stringify(e))};return{getError:function(){return{getMessage:t}}}}),f()(this,"setAdVolume",function(e){var t=a.store,n=t.getState,r=t.dispatch,i=gn.volume(n());Bn()||gn.muted(n())?(e.setVolume(0),Qi(!0)(r)):(e.setVolume(gn.volume(n())),eo(i)(r),Qi(!1)(r))}),f()(this,"createIMAAdManager",function(t){a.IMAAdManager=t.getAdsManager(a.adVideoElement,e.getAdsRenderingSettings()),a.setAdVolume(a.IMAAdManager)}),f()(this,"registerToAdManagerEvents",function(){a.IMAAdManager.addEventListener(google.ima.AdErrorEvent.Type.AD_ERROR,a.onAdError),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.CONTENT_PAUSE_REQUESTED,a.onContentPauseRequested),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.CONTENT_RESUME_REQUESTED,a.onContentResumeRequested),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.STARTED,a.onAdStarted),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.IMPRESSION,a.onAdImpression),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.SKIPPED,a.onAdSkipped),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.COMPLETE,a.onAdCompleted),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.PAUSED,a.onAdPaused),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.RESUMED,a.onAdStarted),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.AD_PROGRESS,a.onAdProgressChanged),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.VOLUME_CHANGED,a.onVolumeChanged),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.VOLUME_MUTED,a.onAdVolumeMutedChanged),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.ALL_ADS_COMPLETED,a.onAdCompleted)}),f()(this,"onIMAAdsManagerLoaded",function(e){var t=a.store.dispatch;a.createIMAAdManager(e),a.registerToAdManagerEvents(),Zi("loaded")(t)}),f()(this,"onAdError",function(e){var t=a.store.dispatch;!function(e){return function(t){t({type:"[MONETIZATION] change ad error",payload:e})}}(e.getError().getMessage())(t),Ji(!1),a.continuePlayingContent()}),f()(this,"onAdImpression",function(e){var t=a.store.dispatch,n=!e.getAd().g.vpaid;a.setPodInfo(e),function(e){e({type:"[MONETIZATION] increase ad impression counter"})}(t),function(e){return function(t){t({type:"[MONETIZATION] update is vast ad",payload:e})}}(n)(t)}),f()(this,"onVolumeChanged",function(e){var t=a.store.dispatch;eo(e.target.getVolume())(t)}),f()(this,"onAdVolumeMutedChanged",function(e){var t=a.store.dispatch;0===e.target.getVolume()?Qi(!0)(t):Qi(!1)(t)}),f()(this,"continuePlayingContent",function(){var e=a.store,t=e.getState,n=e.dispatch,r=hn.videoTagStatus(t());Xi("idle"===r?"play":"resume")(n)}),f()(this,"stopPlayingContent",function(){var e=a.store.dispatch;Xi("pause")(e)}),f()(this,"onContentPauseRequested",function(){a.stopPlayingContent()}),f()(this,"onContentResumeRequested",function(){a.continuePlayingContent()}),f()(this,"onAdPaused",function(){var e=a.store.dispatch;Zi("paused")(e)}),f()(this,"setPodInfo",function(e){var t=e&&e.getAd()&&e.getAd().getAdPodInfo();if(!Un(t)){var n=a.store.dispatch;!function(e,t){return function(n){n({type:"[MONETIZATION] change pod info",payload:{slotNumber:e,podNumber:t}})}}(t.getAdPosition(),a.totalAdRequestMadeAmount)(n)}}),f()(this,"onAdStarted",function(){var e=a.store,t=e.dispatch,n=e.getState,r=gn.volume(n());Zi("playing")(t),0===a.IMAAdManager.getVolume()?a.IMAAdManager.setVolume(0):window.shouldPlayAdRule||a.IMAAdManager.setVolume(r),a.onResize()}),f()(this,"onAdCompleted",function(){var e=a.store.dispatch;Zi("completed")(e)}),f()(this,"onAdSkipped",function(){var e=a.store.dispatch;Zi("skipped")(e)}),f()(this,"onResize",function(){Un(a.IMAAdManager)||(a.IMAAdManager.resize(a.videoPlayerElement.clientWidth,a.videoPlayerElement.clientHeight,google.ima.ViewMode.NORMAL),a.adContainerElement.style.height="".concat(a.videoPlayerElement.clientHeight,"px"))}),f()(this,"onAdProgressChanged",function(e){var t,n,r=a.store,i=r.dispatch,o=r.getState,s=e.getAdData().currentTime,u=e.getAdData().duration,c=_i.adDuration(o());(t=s,function(e){e({type:"[MONETIZATION] change ad current time",payload:t})})(i),c!==u&&(n=u,function(e){e({type:"[MONETIZATION] change ad duration",payload:n})})(i)}),f()(this,"onAnchorStatusChanged",function(){var e=a.store.getState;"processing"!==Pr(e())&&a.onResize()}),f()(this,"changeAdVolume",function(e){Un(a.IMAAdManager)||a.IMAAdManager.setVolume(e)}),f()(this,"changeAdMuted",function(e,t){Un(a.IMAAdManager)||(t?a.IMAAdManager.setVolume(0):a.IMAAdManager.setVolume(e))}),f()(this,"changeAdStatus",function(e){Un(a.IMAAdManager)||("playing"===e&&a.IMAAdManager.resume(),"paused"===e&&a.IMAAdManager.pause())});var s=t.getState;this.store=t,this.adVideoElement=r,this.videoPlayerElement=i,this.adContainerElement=n,this.adDisplayContainer=new google.ima.AdDisplayContainer(n,r),this.createAdLoader(s(),this.adDisplayContainer),this.adDisplayContainer.initialize(),this.anchorStatusStoreSubscriber=new ji(t,e.getAnchorDependencies,this.onAnchorStatusChanged.bind(this)),this.registerForWindowResize(),this.initMutationObserver(o)};f()(to,"getAdsRenderingSettings",function(){var e=new google.ima.AdsRenderingSettings;return e.restoreCustomPlaybackStateOnAdBreakComplete=!0,e.enablePreloading=!1,e.uiElements=[],e.loadVideoTimeout=15e3,e}),f()(to,"getAnchorDependencies",function(e){return[Pr(e)]});var no=function e(t,n,r,i,o,a){var s=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"playerId",void 0),f()(this,"adScheduler",void 0),f()(this,"adHandler",void 0),f()(this,"imaLoadingStatusSubscriber",void 0),f()(this,"adStatusSubscriber",void 0),f()(this,"videoTagStatusSubscriber",void 0),f()(this,"adContainer",void 0),f()(this,"adVideoElement",void 0),f()(this,"videoPlayerElement",void 0),f()(this,"playerContainer",void 0),f()(this,"pendingMidrollAdPlay",!1),f()(this,"pendingPrerollAdPlay",!1),f()(this,"pendingPrerollAdTag",null),f()(this,"pendingMidrollNumber",null),f()(this,"pendingAdStatusStoreSubscriber",void 0),f()(this,"adMutedStoreSubscriber",void 0),f()(this,"adVolumeStoreSubscriber",void 0),f()(this,"onMidrollAdOpportunity",function(){var e=s.store,t=e.dispatch,n=e.getState,r=_i.adStatus(n()),i=bi.continuePlayingWhileWaitingForAd(n());"loaded"===r?s.playAd(!0):"requested"===r&&(s.pendingMidrollAdPlay=!0,i||(Xi("pause")(t),Ji(!0)(t))),function(e){e({type:"[MONETIZATION] increase ad Opportunity counter"})}(t)}),f()(this,"onPrerollAdOpportunity",function(e){var t=s.store,n=t.getState,r=t.dispatch,i=Fi.loadingImaStatus(n());Un(s.adHandler)?"loading"!==i&&""!==i||(Ji(!0)(r),s.pendingPrerollAdPlay=!0,s.pendingPrerollAdTag=e):(s.pendingPrerollAdPlay=!0,Ji(!0)(r),s.adHandler.loadNewAd(e,"preroll"))}),f()(this,"onPreMidrollAdOpportunity",function(e,t){Un(s.adHandler)||(e.currentTime>=e.midrollTime&&(s.pendingMidrollAdPlay=!0),s.pendingMidrollNumber=e.midrollNumber,s.adHandler.loadNewAd(t,"midroll"))}),f()(this,"hasPendingAd",function(){return s.hasPendingMidrollAdPlay()||s.hasPendingPrerollAdPlay()}),f()(this,"onAdStatusChanged",function(e){var t=s.store.dispatch,n=_i.adStatus(e);"completed"===n&&Ji(!1)(t);var r=bi.continuePlayingWhileWaitingForAd(e),i=_i.loadingAd(e);"playing"!==n&&"error"!==n||r||!i||Ji(!1)(t),s.hasPendingAd()&&"loaded"===n?s.playAd(s.hasPendingMidrollAdPlay()):s.hasPendingAd()&&"error"===n?(Ji(!1),s.clearPendingMidroll(),s.clearPendingPreroll()):Hi(n)||(Ji(!1),function(e){e({type:"[MONETIZATION] clear ad data"})}(t))}),f()(this,"clearPendingMidroll",function(){s.pendingMidrollNumber=null,s.pendingMidrollAdPlay=!1}),f()(this,"clearPendingPreroll",function(){s.pendingPrerollAdPlay=!1,s.pendingPrerollAdTag=null}),f()(this,"onVideoTagStatusChanged",function(e){"complete"===hn.videoTagStatus(e)&&function(e){e({type:"[MONETIZATION] clear played midrolls"})}(s.store.dispatch)}),f()(this,"hasPendingMidrollAdPlay",function(){return s.pendingMidrollAdPlay}),f()(this,"hasPendingPrerollAdPlay",function(){return s.pendingPrerollAdPlay}),f()(this,"playAd",function(e){var t,n=s.store.dispatch,r=s.adHandler.playAd();e?((t=s.pendingMidrollNumber,function(e){e({type:"[MONETIZATION] add 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Ki(t,this),this.adStatusSubscriber=new ji(t,e.getAdStatusDependencies,this.onAdStatusChanged.bind(this)),this.videoTagStatusSubscriber=new ji(t,e.getVideoTagStatusDependencies,this.onVideoTagStatusChanged.bind(this)),e.canUseIMA(u())?this.adHandler=new to(t,r,i,o,a):this.imaLoadingStatusSubscriber=new ji(t,e.getIMALoadingStatusDependencies,this.onIMALoadingStatusChanged.bind(this)),this.pendingAdStatusStoreSubscriber=new ji(t,e.getPendingAdStatusDependencies,this.onPendingAdStatusChanged.bind(this)),this.adMutedStoreSubscriber=new ji(t,e.getAdMutedDependencies,this.onAdMutedChanged.bind(this)),this.adVolumeStoreSubscriber=new ji(t,e.getAdVolumeDependencies,this.onAdVolumeChanged.bind(this))};f()(no,"getAdStatusDependencies",function(e){return[_i.adStatus(e)]}),f()(no,"getVideoTagStatusDependencies",function(e){return[hn.videoTagStatus(e)]}),f()(no,"getIMALoadingStatusDependencies",function(e){return[Fi.loadingImaStatus(e)]}),f()(no,"canUseIMA",function(e){return"success"===Fi.loadingImaStatus(e)}),f()(no,"getPendingAdStatusDependencies",function(e){return[_i.pendingAdStatus(e)]}),f()(no,"getAdMutedDependencies",function(e){return[_i.adMuted(e)]}),f()(no,"getAdVolumeDependencies",function(e){return[_i.adVolume(e)]});var ro=function(e,t){!function(e,t){var n=document.getElementById(vn(t));B(b(Li,{store:e,playerId:t}),n)}(e,t);var n=function(e){var t=Ri(e);return document.getElementById(t)}(t),r=function(e){var t=Bn()?Di(e):En(e);return document.getElementById(t)}(t),i=function(e){var t=En(e);return document.getElementById(t)}(t),o=function(e){var t=bn(e);return document.getElementById(t)}(t);return new no(e,t,n,r,i,o)},io=n(4),oo=n.n(io),ao=n(7),so=n.n(ao),uo=function(){function e(){Ai()(this,e),f()(this,"duration",void 0),f()(this,"position",void 0),f()(this,"previousPosition",void 0),f()(this,"loadTime",void 0),f()(this,"adOrder",void 0),f()(this,"adType",void 0),f()(this,"adDuration",void 0),f()(this,"errorMessage",void 0),f()(this,"adPodNumber",void 0),f()(this,"adSlotNumber",void 0)}return Vi()(e,[{key:"setDuration",value:function(e){return this.duration=e,this}},{key:"setPosition",value:function(e){return this.position=e,this}},{key:"setPreviousPosition",value:function(e){return this.previousPosition=e,this}},{key:"setLoadTime",value:function(e){return this.loadTime=e,this}},{key:"setAdOrder",value:function(e){return this.adOrder=e,this}},{key:"setAdType",value:function(e){return this.adType=e,this}},{key:"setAdDuration",value:function(e){return this.adDuration=e,this}},{key:"setErrorMessage",value:function(e){return this.errorMessage=e,this}},{key:"setAdPodNumber",value:function(e){return this.adPodNumber=e,this}},{key:"setAdSlotNumber",value:function(e){return this.adSlotNumber=e,this}},{key:"build",value:function(){var e=[];return jn(this.position)||e.push("video current position=".concat(Hn(this.position),"sec")),jn(this.duration)||e.push("video duration time=".concat(Hn(this.duration),"sec")),jn(this.loadTime)||e.push("video load time=".concat(this.loadTime,"milliseconds")),jn(this.previousPosition)||e.push("previous position=".concat(Hn(this.previousPosition),"sec")),jn(this.adOrder)||e.push("ad order=".concat(this.adOrder)),jn(this.adType)||e.push("ad type=".concat(this.adType)),jn(this.adDuration)||e.push("ad duration=".concat(Hn(Number(this.adDuration)),"sec")),jn(this.adPodNumber)||e.push("pod number=".concat(this.adPodNumber)),jn(this.adSlotNumber)||e.push("slot number=".concat(this.adSlotNumber)),jn(this.errorMessage)||e.push("error message=".concat(this.errorMessage)),e.join(";")}}]),e}(),co="mmPlus GTM data ready to GA",lo="mmPlus GTM event to GA",po={EMBED:"vplayer video player embed",FIRST_PLAY:"vplayer video first play",COMPLETION_25_PERCENTAGE:"vplayer video 25% complete",COMPLETION_50_PERCENTAGE:"vplayer video 50% complete",COMPLETION_75_PERCENTAGE:"vplayer video 75% complete",COMPLETION_90_PERCENTAGE:"vplayer video 90% complete",AD_BLOCK:"vplayer video ad block",AD_REQUEST:"vplayer video ad request",AD_IMPRESSION:"vplayer video ad impression",AD_ERROR:"vplayer video ad error",AD_VIEWABLE_IMPRESSION:"vplayer video ad viewable impression",AD_COMPLETE:"vplayer video ad complete",AD_SKIP:"vplayer video ad skip",AD_PAUSE:"vplayer video ad pause",VIDEO_COMPLETE:"vplayer video complete",FULLSCREEN_ON:"vplayer video fullscreen on",FULLSCREEN_OFF:"vplayer video fullscreen off",SEEK:"vplayer video position seeked",VIDEO_MUTE:"vplayer video mute",VIDEO_UNMUTE:"vplayer video unmute",CONTROLS_MUTE_OR_UNMUTE:"controls Mute/Unmute button click",CONTROLS_PLAY_OR_PAUSE:"controls Play/Pause button click",CONTROLS_FULLSCREEN:"controls Fullscreen button click",CONTROLS_NEXT_VIDEO:"controls Next Video button click",CONTROLS_SETTINGS:"controls Settings button click",MINI_PLAYER_CLOSE:"vplayer video miniplayer close",LOADING_CONTENT_ERROR:"vplayer video player error",PLAYER_ERROR:"vplayer general player error",CONTENT_VIEWABLE_IMPRESSION:"vplayer video content viewable impression"},fo="loading ad provider library failed",ho="mid",yo=function e(t,n){var r=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"analyticsEventsCallbacks",void 0),f()(this,"videoMuteSubscriber",void 0),f()(this,"videoFullscreenSubscriber",void 0),f()(this,"onMuteStateChanged",function(e){var t=gn.muted(e),n=hn.currentVideoTimeFragment(e),i=(new uo).setPosition(n).build(),o=t?po.VIDEO_MUTE:po.VIDEO_UNMUTE;r.analyticsEventsCallbacks.onEvent(o,i)}),f()(this,"onFullsScreenStateChanged",function(e){var t=gn.fullscreen(e),n=hn.currentVideoTimeFragment(e),i=(new uo).setPosition(n).build(),o=t?po.FULLSCREEN_ON:po.FULLSCREEN_OFF;r.analyticsEventsCallbacks.onEvent(o,i)}),this.store=t,this.analyticsEventsCallbacks=n,this.videoMuteSubscriber=new ji(t,e.getVideoMuteDependencies,this.onMuteStateChanged.bind(this)),this.videoFullscreenSubscriber=new ji(t,e.getVideoFullscreenDependencies,this.onFullsScreenStateChanged.bind(this))};f()(yo,"getVideoMuteDependencies",function(e){return[gn.muted(e)]}),f()(yo,"getVideoFullscreenDependencies",function(e){return[gn.fullscreen(e)]});var go=n(3),vo=n.n(go),mo=n(8),bo=n.n(mo),Oo=n(9),_o=n.n(Oo),So=n(5),Eo=n.n(So);n(20);var wo={root:null,threshold:.5,rootMargin:"0px"},Po=function(){function e(t,n,r){Ai()(this,e),f()(this,"store",void 0),f()(this,"observableElement",void 0),f()(this,"callback",void 0),f()(this,"isViewableTimeoutHandler",null),f()(this,"observer",void 0),f()(this,"didReport",!1),this.store=t,this.observableElement=n,this.callback=r,this.observer=new IntersectionObserver(this.onIntersecting.bind(this),wo)}return Vi()(e,[{key:"unobserve",value:function(){this.observer.unobserve(this.observableElement),this.clearIsViewableTimeout()}},{key:"observe",value:function(){this.observer.observe(this.observableElement)}},{key:"onPlay",value:function(){this.didReport||this.observe()}},{key:"onPause",value:function(){this.unobserve()}},{key:"onComplete",value:function(){this.didReport=!1,this.unobserve()}},{key:"onIntersecting",value:function(e){var t=e[0].isIntersecting;null===this.isViewableTimeoutHandler&&t?this.isViewableTimeoutHandler=setTimeout(this.notifyViewable.bind(this),2e3):this.clearIsViewableTimeout()}},{key:"clearIsViewableTimeout",value:function(){clearTimeout(this.isViewableTimeoutHandler),this.isViewableTimeoutHandler=null}},{key:"notifyViewable",value:function(){var e=this.store.getState;this.didReport=!0,this.callback(e()),this.unobserve()}}]),e}();function To(e){var t=function(){if("undefined"===typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"===typeof Proxy)return!0;try{return Date.prototype.toString.call(Reflect.construct(Date,[],function(){})),!0}catch(e){return!1}}();return function(){var n,r=Eo()(e);if(t){var i=Eo()(this).constructor;n=Reflect.construct(r,arguments,i)}else n=r.apply(this,arguments);return _o()(this,n)}}var Ao=function(e){bo()(n,e);var t=To(n);function n(e,r,i){var o;return Ai()(this,n),o=t.call(this,e,r,i),f()(vo()(o),"videoTagStatusSubscriber",void 0),f()(vo()(o),"onVideoTagStatusChanged",function(e){var t=hn.videoTagStatus(e);"playing"===t?o.onPlay():"paused"===t||"seeking"===t?o.onPause():"complete"!==t&&"error"!==t||o.onComplete()}),o.videoTagStatusSubscriber=new ji(e,n.getVideoTagStatusDependencies,o.onVideoTagStatusChanged.bind(vo()(o))),o}return 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fa(fa({},e),{},{playbackMethod:Un(r)?e.playbackMethod:r,playerId:Un(i)?e.playerId:i,playerInstanceUniqId:n,playerMode:Fn()?"mobile":"desktop"})}(e,n.initiateParams,n.playerInstanceUniqId));case"[CORE] reset player data time params":return fa(fa({},e),{},{currentVideoTimeFragment:0,currentVideoBufferedTime:0,currentVideoDuration:0,currentVideoTime:0});case"[COMMON] set mute video":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{muted:t.payload})});case"[COMMON] set volume":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{volume:t.payload})});case"[COMMON] change selected settings category":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{selectedSettingsCategory:t.payload})});case"[COMMON] change settings speed":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{speed:t.payload})});case"[COMMON] change settings quality":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{quality:t.payload})});case"[COMMON] set fullscreen":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{fullscreen:fa(fa({},e.playerSettings.fullscreen),{},{isFullscreenOn:t.payload,pendingFullscreenRequest:""})})});case"[COMMON] set fullscreen request":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{fullscreen:fa(fa({},e.playerSettings.fullscreen),{},{pendingFullscreenRequest:t.payload})})});case"[COMMON] set pending video status":var r=t.payload.pendingStatusObject;return fa(fa({},e),{},{pendingVideoTagStatus:fa({},r)});case"[COMMON] set player mode":return fa(fa({},e),{},{playerMode:t.payload});case"[CORE] update video current fragment position":return fa(fa({},e),{},{currentVideoTimeFragment:t.payload});case"[CORE] update video current position":return fa(fa({},e),{},{currentVideoTime:t.payload});case"[CORE] update video current buffered time":return fa(fa({},e),{},{currentVideoBufferedTime:t.payload});case"[CORE] update video current duration":return fa(fa({},e),{},{currentVideoDuration:t.payload});case"[CORE] change video tag status":return fa(fa({},e),{},{videoTagStatus:t.payload});case"[CORE] update player visibility":return fa(fa({},e),{},{playerVisibility:t.payload});case"[CORE] update placeholder visibility":return fa(fa({},e),{},{playerPlaceholderVisibility:t.payload});case"[CORE] change loading player status":return fa(fa({},e),{},{loadingPlayer:t.payload});case"[COMMON] show black screen with loader":return fa(fa({},e),{},{loader:fa(fa({},e.loader),{},{showBlackScreen:t.payload})});case"[CORE] set player size":return fa(fa({},e),{},{playerSize:t.payload});case"[COMMON] set error message":return fa(fa({},e),{},{errorMessage:t.payload});default:return e}},brandingData:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:va,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return ga({},function(e,t){var n=t.powered_by_strip,r=t.brand_logo,i=t.brand_logo_click_url,o=t.brand_color;return ga(ga({},e),{},{showVoltaxLogo:Un(n)?e.showVoltaxLogo:n,brandingLogoSrc:Un(r)?e.brandingLogoSrc:r,brandingLogoUrl:Un(i)?e.brandingLogoUrl:i,brandingColor:Un(o)?e.brandingColor:o})}(e,t.payload.initiateParams));default:return e}},anchorOptions:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Oa,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return ba({},function(e,t){var n=t.anchor_options;if(!Un(n)){var r=n.anchoring_appearance,i=n.can_close,o=n.closable_ad,a=n.close_after,s=n.continue_streaming,u=n.orientation,c=n.margins,l=n.sticky_below_class_name,d=n.width,p=Un(c)?e.margins:{top:Number.isInteger(c.top)?c.top:e.margins.top,bottom:Number.isInteger(c.bottom)?c.bottom:e.margins.bottom,left:Number.isInteger(c.left)?c.left:e.margins.left,right:Number.isInteger(c.right)?c.right:e.margins.right};return ba(ba({},e),{},{anchoringAppearance:r||e.anchoringAppearance,canClose:Un(i)?e.canClose:i,orientation:Un(u)?e.orientation:u,closableAd:Un(o)?e.closableAd:o,closeAfter:Un(a)?e.closeAfter:a,continueStreaming:Un(s)?e.continueStreaming:s,stickyBelowClassName:Un(l)?e.stickyBelowClassName:l,width:Un(d)?e.width:d,margins:p,anchorData:ba(ba({},e.anchorData),{},{anchorEnabled:!0})})}return e}(e,t.payload.initiateParams));case"[COMMON] set anchor enable":return ba(ba({},e),{},{anchorData:ba(ba({},e.anchorData),{},{anchorEnabled:t.payload})});case"[ANCHOR] update is anchor status":return ba(ba({},e),{},{anchorData:ba(ba({},e.anchorData),{},{anchorStatus:t.payload})});case"[COMMON] set anchor disabled by user":return ba(ba({},e),{},{anchorData:ba(ba({},e.anchorData),{},{anchorDisabledByUser:t.payload})});default:return e}},monetization:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:wa,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Sa({},function(e,t){var n=t.monetization;if(Un(n))return e;var r=n.ad_tag,i=n.ad_type,o=n.vpaid_mode,a=n.ad_request_timeout,s=n.continue_content_play_while_waiting_for_ad,u=n.midrolls,c=u&&u.on&&u.on.sort(Wn),l=Un(s)?e.continuePlayingWhileWaitingForAd:s,d=c?c.indexOf(0):-1,p=-1!==d&&!l;return p&&(c=c.splice(d,1)),Sa(Sa({},e),{},{midrolls:Sa(Sa({},e.midrolls),{},{every:u&&u.every,on:c}),prerollEnabled:p,adRequestTimeout:Un(a)?e.adRequestTimeout:parseInt(a,10),vpaidMode:Un(o)?e.vpaidMode:o,continuePlayingWhileWaitingForAd:l,adsData:Sa(Sa({},e.adsData),{},{adType:Un(i)?e.adsData.adType:i,adTagUrlTemplate:Un(r)?e.adsData.adTagUrlTemplate:r})})}(e,t.payload.initiateParams));case"[COMMON] set new ad tag url template":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adTagUrlTemplate:t.payload})});case"[MONETIZATION] change ad status":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adStatus:t.payload,adErrorMessage:null})});case"[MONETIZATION] change ad tag":var n=t.payload,r=n.adUnit,i=n.adTag;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{currentAdTag:i,adUnit:r})});case"[MONETIZATION] change pending ad status":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{pendingAdStatus:t.payload})});case"[MONETIZATION] change ad error":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adStatus:"error",adErrorMessage:t.payload})});case"[MONETIZATION] increase ad impression counter":var o=e.adsData.adImpression;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adImpression:o+1})});case"[MONETIZATION] increase ad Opportunity counter":var a=e.adsData.adOpportunity;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adOpportunity:a+1})});case"[MONETIZATION] add played midroll number":var s=e.adsData.playedMidrolls,u=In()(s);return u.push(t.payload),Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adOrder:t.payload,playedMidrolls:u})});case"[MONETIZATION] clear played midrolls":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{playedMidrolls:[]})});case"[MONETIZATION] clear ad data":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adOrder:0,currentAdTag:null,adDuration:0,adUnit:""})});case"[MONETIZATION] change ad duration":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adDuration:t.payload})});case"[MONETIZATION] update is vast ad":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{isVastAd:t.payload})});case"[MONETIZATION] change ad current time":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adCurrentTime:t.payload})});case"[MONETIZATION] update ad muted":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adMuted:t.payload})});case"[MONETIZATION] change ad volume":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adVolume:t.payload})});case"[MONETIZATION] change pod info":var c=t.payload,l=c.podNumber,d=c.slotNumber;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{podNumber:l,slotNumber:d})});case"[MONETIZATION] change loading ad status":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{loadingAd:t.payload})});default:return e}},mediaData:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:ja,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Va({},function(e,t){var n=t.content_type,r=t.media_id,i=t.display_title;return Va(Va({},e),{},{mediaType:Un(n)?e.mediaType:n,mediaId:Un(r)?e.mediaId:r,videoData:Va(Va({},e.videoData),{},{showTitle:!!Un(i)||i})})}(e,t.payload.initiateParams));case"[CORE] load video request":return Va(Va({},e),{},{loadingMedia:!0});case"[CORE] load video request success":return Va(Va({},e),{},{loadingMedia:!1,videoList:t.payload});case"[CORE] set current video":var n=t.payload,r=n.index,i=n.videoData;return Va(Va({},e),{},{activeVideoIndex:r,videoData:i});case"[CORE] load video request error":return Va(Va({},e),{},{loadingMedia:!1,mediaLoadingError:t.payload});case"[COMMON] media request":var o=t.payload.mediaRequestObject;return Va(Va({},e),{},{mediaRequest:Va({},o)});default:return e}},semanticOptions:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Ba,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Fa({},function(e,t){var n=t.semantic_options;if(Un(n))return e;var r=n.minimum_date_factor,i=n.promoted_videos,o=n.scan_images_on_page,a=n.scanned_element,s=n.scanned_element_type,u=n.scoped_keywords,c=n.tags;return Fa(Fa({},e),{},{minimumDateFactor:Un(r)?e.minimumDateFactor:r,promotedVideos:Un(i)?e.promotedVideos:i,scanImagesOnPage:Un(o)?e.scanImagesOnPage:o,scannedElement:Un(a)?e.scannedElement:a,scannedElementType:Un(s)?e.scannedElementType:s,scopedKeywords:Un(u)?e.scopedKeywords:u,tags:Un(c)?e.tags:c})}(e,t.payload.initiateParams));default:return e}},userInteraction:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Wa,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[USER INTERACTION] change user interaction":return qa(qa({},e),{},{userInteractionType:t.payload});default:return e}},splitView:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:$a,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Ga({},function(e,t){var n=t.anchor_options;if(!Un(n)){var r=n.split_view,i=n.split_view_ratio;return Ga(Ga({},e),{},{splitViewRatio:Un(r)||!r||Un(i)?e.splitViewRatio:i})}return e}(e,t.payload.initiateParams));default:return e}},discovery:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Za,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Ya({},function(e,t){var n=t.next_video;return Un(n)?e:Ya(Ya({},e),{},{nextVideo:Xa(n)})}(e,t.payload.initiateParams));case"[DISCOVERY] show up next":return Ya(Ya({},e),{},{showUpNext:t.payload});case"[DISCOVERY] show skippable content":return Ya(Ya({},e),{},{showSkippableContent:t.payload});default:return e}}}),Qa=[],es=!1,ts=function e(){return function(t){return function(n){if(es)return Qa.push(n),null;es=!0;var r=t(n);return es=!1,Qa.length>0&&e()(t)(Qa.shift()),r}}},ns=function(e){var t=[];if(function(e){return!Un(e)&&!Un(e.enable_redux_debugging)&&e.enable_redux_debugging}(e)){var n=window&&window.__REDUX_DEVTOOLS_EXTENSION__&&window.__REDUX_DEVTOOLS_EXTENSION__();"function"===typeof n&&t.push(n)}var r=Et.apply(void 0,[wt(ua,ts)].concat(t));return vt(Ja,r)},rs=function(){function e(t){Ai()(this,e),f()(this,"playerVisibilitySubscriber",void 0),f()(this,"videoTagStatusSubscriber",void 0),f()(this,"shouldPlayIfLazyplay",!0),f()(this,"shouldPlayIfAutoplayWhenViewable",!0),f()(this,"videoPausedByObserver",!1),this.store=t,this.playerVisibilitySubscriber=null,this.videoTagStatusSubscriber=null,this.playAccordingToPlaybackMethod()}return Vi()(e,[{key:"lazyplayHandler",value:function(e){hn.playerVisibility(e)>=.5&&(this.playVideo(),this.shouldPlayIfLazyplay=!1)}},{key:"autoplayWhenViewableHandler",value:function(e){hn.playerVisibility(e)>=.5?this.playVideo():this.pauseVideo()}},{key:"onPlayerVisibilityChanged",value:function(e){var t=hn.playbackMethod(e);"lazyplay"===t&&this.shouldPlayIfLazyplay&&this.lazyplayHandler(e),"autoplay_when_viewable"===t&&this.shouldPlayIfAutoplayWhenViewable&&this.autoplayWhenViewableHandler(e)}},{key:"onVideoTagStatusChanged",value:function(e){var t=hn.videoTagStatus(e);"paused"!==t||this.videoPausedByObserver||(this.shouldPlayIfAutoplayWhenViewable=!1),"playing"===t&&(this.shouldPlayIfAutoplayWhenViewable=!0,this.videoPausedByObserver=!1)}},{key:"initiatePlayerVisibilitySubscriber",value:function(){this.playerVisibilitySubscriber=new ji(this.store,e.getPlayerVisibilityDependencies,this.onPlayerVisibilityChanged.bind(this))}},{key:"initiateVideoTagStatusSubscriber",value:function(){this.videoTagStatusSubscriber=new ji(this.store,e.getVideoTagStatusDependencies,this.onVideoTagStatusChanged.bind(this))}},{key:"playVideo",value:function(){var e=this.store,t=e.dispatch,n=e.getState;"idle"===hn.videoTagStatus(n())?on("play")(t):on("resume")(t)}},{key:"pauseVideo",value:function(){var e=this.store,t=e.dispatch,n=e.getState;"paused"!==hn.videoTagStatus(n())&&(this.videoPausedByObserver=!0,on("pause")(t))}},{key:"playAccordingToPlaybackMethod",value:function(){var e=this.store,t=e.dispatch,n=(0,e.getState)();switch(hn.playbackMethod(n)){case"autoplay":this.playVideo();break;case"lazyplay":this.initiatePlayerVisibilitySubscriber();break;case"autoplay_when_viewable":this.initiatePlayerVisibilitySubscriber(),this.initiateVideoTagStatusSubscriber();break;case"none":an(!1)(t)}}}],[{key:"getPlayerVisibilityDependencies",value:function(e){return[hn.playerVisibility(e)]}},{key:"getVideoTagStatusDependencies",value:function(e){return[hn.videoTagStatus(e)]}}]),e}(),is=function(){function e(t,n,r,i){var o=this;Ai()(this,e),f()(this,"videoStatusSubscriber",void 0),f()(this,"videoListSubscriber",void 0),f()(this,"mediaRequestSubscriber",void 0),f()(this,"playerVisibilitySubscriber",void 0),f()(this,"playbackMethodManager",void 0),f()(this,"store",void 0),f()(this,"loadContent",function(e,t,n,r){o.loadMedia(t,n,r).then(function(){o.playbackMethodManager=new rs(e)})}),f()(this,"loadMedia",function(e,t,n){var r=o.store,i=r.dispatch,a=r.getState,s=Dn.showTitle(a());if("semantic"===e){var u=pn.semanticOptions(a());return Na(u,s,n)(i)}return ka(t,s,n)(i)}),this.store=t,this.videoStatusSubscriber=new ji(t,e.getVideoStatusDependencies,this.onVideoStatusChanged.bind(this)),this.videoListSubscriber=new ji(t,e.getVideoListDependencies,this.onVideoListChanged.bind(this)),this.mediaRequestSubscriber=new ji(t,e.getMediaRequestDependencies,this.onMediaRequestChanged.bind(this)),this.playerVisibilitySubscriber=null,this.loadContent(t,r,n,i)}return Vi()(e,null,[{key:"createInstance",value:function(t,n,r,i){return new e(t,n,r,i)}}]),Vi()(e,[{key:"playNextVideo",value:function(e){var t=this.store.dispatch,n=Cn.videoList(e),r=Cn.activeVideoIndex(e)+1;n.length>1&&r>=n.length&&(r=0),r<n.length&&(!function(e){e({type:"[CORE] reset player data time params"})}(t),La(r,n[r])(t),on("play")(t))}},{key:"playPreviousVideo",value:function(e){var t=this.store.dispatch,n=Cn.videoList(e),r=Cn.activeVideoIndex(e);if(r>0){var i=r-1;La(i,n[i])(t),on("play")(t)}}},{key:"onVideoStatusChanged",value:function(e){"complete"===hn.videoTagStatus(e)&&this.playNextVideo(e)}},{key:"onVideoListChanged",value:function(e){var t=this.store.dispatch,n=Cn.videoList(e);!jn(n)&&n.length>0&&La(0,n[0])(t)}},{key:"onMediaRequestChanged",value:function(e){var t=Cn.mediaRequest(e);switch(t.type){case"playNewVideo":this.loadMedia("specific",t.value);break;case"playNextVideo":this.playNextVideo(e);break;case"playPreviousVideo":this.playPreviousVideo(e)}}}],[{key:"getVideoStatusDependencies",value:function(e){return[hn.videoTagStatus(e)]}},{key:"getVideoListDependencies",value:function(e){return[Cn.videoList(e)]}},{key:"getMediaRequestDependencies",value:function(e){return[Cn.mediaRequest(e)]}}]),e}(),os=function e(t){var n=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"onDependencyFailure",function(e,t){console.log("onDependencyFailure",e,t);var r=n.store,i=r.dispatch,o=r.getState;switch(e){case"ima":"blocked"!==Fi.loadingImaStatus(o())&&Qn("error")(i);break;case"hls":er("error")(i)}}),f()(this,"onDependencyReady",function(e){var t=n.store.dispatch;switch(e){case"ima":Qn("success")(t);break;case"hls":er("success")(t)}}),this.store=t},as=function(e){return function(t){t({type:"[COMMON] set fullscreen",payload:e})}},ss=function(){function e(t,n){var r=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"videoTag",void 0),f()(this,"pendingFullscreenSubscriber",void 0),f()(this,"adStatusSubscriber",void 0),f()(this,"playerUniqId",void 0),f()(this,"onAdStatusChanged",function(e){var t=_i.adStatus(e),n=r.videoTag.webkitDisplayingFullscreen;"playing"===t&&Bn()&&n&&r.exitFullscreen(r.videoTag)}),f()(this,"isPlayerInFullscreen",function(){var e=document,t=Bn()?En(r.playerUniqId):bn(r.playerUniqId);return Un(e.fullscreenElement)?!Un(e.webkitFullscreenElement)&&0===e.webkitFullscreenElement.id.localeCompare(t):0===e.fullscreenElement.id.localeCompare(t)}),f()(this,"changePlayerWidth",function(e){r.videoTag.style.width=e?"100%":"auto"}),f()(this,"onFullscreenChanged",function(){var e=r.store.dispatch,t=r.isPlayerInFullscreen();r.changePlayerWidth(t),as(t)(e)}),f()(this,"onFullscreenChangedIos",function(){var e=r.store.dispatch,t=r.videoTag.webkitDisplayingFullscreen;t||on("resume")(e),r.changePlayerWidth(t),as(t)(e)}),f()(this,"onPendingFullscreenRequestChanged",function(e){var t=gn.pendingFullscreenRequest(e);"enter"===t?r.enterFullscreen(r.videoTag):"exit"===t&&r.exitFullscreen(r.videoTag)}),f()(this,"getFullScreenElement",function(e,t){var n=document.getElementById(bn(r.playerUniqId));return Bn()?t:e?document:n}),f()(this,"enterFullscreen",function(e){var t=r.getFullScreenElement(!1,e);Bn()?t.webkitEnterFullscreen():document.webkitExitFullscreen?t.webkitRequestFullscreen():document.webkitCancelFullScreen?t.webkitRequestFullScreen():document.mozCancelFullScreen?t.mozRequestFullScreen():document.msExitFullscreen&&t.msRequestFullscreen()}),f()(this,"exitFullscreen",function(e){var t=r.getFullScreenElement(!0,e);document.webkitExitFullscreen||Bn()?t.webkitExitFullscreen():document.webkitCancelFullScreen?t.webkitCancelFullScreen():document.mozCancelFullScreen?t.mozCancelFullScreen():document.msExitFullscreen&&t.msExitFullscreen()}),this.store=t,this.videoTag=document.getElementById(En(n)),this.playerUniqId=n,document.addEventListener("fullscreenchange",this.onFullscreenChanged.bind(this)),document.addEventListener("webkitfullscreenchange",this.onFullscreenChanged.bind(this)),Bn()&&(this.videoTag.addEventListener("webkitendfullscreen",this.onFullscreenChangedIos.bind(this)),this.videoTag.addEventListener("webkitbeginfullscreen",this.onFullscreenChangedIos.bind(this))),this.pendingFullscreenSubscriber=new ji(t,e.getPendingFullscreenDependencies,this.onPendingFullscreenRequestChanged.bind(this)),this.adStatusSubscriber=new ji(t,e.getAdStatusDependencies,this.onAdStatusChanged.bind(this))}return Vi()(e,null,[{key:"createInstance",value:function(t,n){return new e(t,n)}}]),Vi()(e,null,[{key:"getPendingFullscreenDependencies",value:function(e){return[gn.pendingFullscreenRequest(e)]}},{key:"getAdStatusDependencies",value:function(e){return[_i.adStatus(e)]}}]),e}();function us(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter(function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable})),n.push.apply(n,r)}return n}function cs(e){for(var t=1;t<arguments.length;t++){var n=null!=arguments[t]?arguments[t]:{};t%2?us(Object(n),!0).forEach(function(t){f()(e,t,n[t])}):Object.getOwnPropertyDescriptors?Object.defineProperties(e,Object.getOwnPropertyDescriptors(n)):us(Object(n)).forEach(function(t){Object.defineProperty(e,t,Object.getOwnPropertyDescriptor(n,t))})}return e}var ls,ds=function(e){return function(e){return e&&window.monti.playerConfigs&&window.monti.playerConfigs[e]}(e)?function(e){return window.monti.playerConfigs[e]}(e):window.monti.playerConfigs?window.monti.playerConfigs&&window.monti.playerConfigs[Object.keys(window.monti.playerConfigs)[0]]:null},ps=function e(t){var n=this;Ai()(this,e),f()(this,"videoTag",void 0),f()(this,"isBufferError",void 0),f()(this,"hls",void 0),f()(this,"hlsSetup",function(e,t,r,i){n.initiateHls(e),n.loadHlsSource(e,t,r,i)}),f()(this,"detachMedia",function(){Un(n.hls)||(n.hls.detachMedia(),n.hls.destroy(),n.hls=null)}),f()(this,"initiateHls",function(e){n.hls=new e,n.hls.attachMedia(n.videoTag)}),f()(this,"loadHlsSource",function(e,t,r,i){n.hls.on(e.Events.MEDIA_ATTACHED,function(){n.hls.loadSource(t)}),n.hls.on(e.Events.ERROR,function(t,o){n.mapHlsToErrors(e,o,i),t.details===e.ErrorDetails.BUFFER_STALLED_ERROR&&(r(!0),n.isBufferError=!0)}),n.hls.on(e.Events.FRAG_BUFFERED,function(){n.isBufferError&&(r(!1),n.isBufferError=!1)})}),f()(this,"mapHlsToErrors",function(e,t,r){if(t.fatal)switch(t.type){case 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Os={READY_EVENT:"ready",PLAY_EVENT:"play",PAUSE_EVENT:"pause",TIME_EVENT:"time",SEEK_EVENT:"seek",COMPLETE_EVENT:"complete",VOLUME_EVENT:"volume",MUTE_EVENT:"mute"},_s=Object.values(Os),Ss={FULLSCREEN_EVENT:"fullscreen",ANCHOR_STATUS_EVENT:"anchorStatusChanged",ANCHOR_CLOSED_EVENT:"anchorClosed"},Es={AD_PLAY_EVENT:"adPlay",AD_PAUSE_EVENT:"adPause",AD_RESUME_EVENT:"adResume",AD_COMPLETE_EVENT:"adComplete",AD_TIME_EVENT:"adTime",AD_MUTE_EVENT:"adMute",AD_SKIPPED_EVENT:"adSkipped",AD_ERROR_EVENT:"adError",AD_BLOCK_EVENT:"adBlock",AD_REQUEST_EVENT:"adRequest",AD_OPPORTUNITY_EVENT:"adOpportunity",AD_IMPRESSION_EVENT:"adImpression"},ws=Object.values(Es),Ps=Object.values(bs(bs(bs({},Os),Es),Ss)),Ts=function(){function e(t,n){var r=this;Ai()(this,e),f()(this,"eventsCallbacksHandler",void 0),f()(this,"store",void 0),f()(this,"videoStatusSubscriber",void 0),f()(this,"videoMuteSubscriber",void 0),f()(this,"videoVolumeSubscriber",void 0),f()(this,"videoTimeFragmentSubscriber",void 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{"is_conflicting_with_other_jw_players":false,"programmatic_play_with_sound_on_desktop":false,"referrer_id":"af93e181-b289-0560-a2bf-808e93bb05bc","width":"100","comscore_publisher_id":"18120612","monetization":{"ad_type":"static_tag","continue_content_play_while_waiting_for_ad":false,"strategy":"on_player_load","ad_request_timeout":"10000","midrolls":{"on":[0]},"vpaid_mode":"ENABLED","ad_tag":"https://pubads.g.doubleclick.net/gampad/ads?sz=400x300|640x480|480x270|640x360&iu=/175840252/MMPlus/smithsonianmag/Video&impl=s&gdfp_req=1&env=vp&output=vast&unviewed_position_start=1&url=##REFERRER_URL_UNESC##&description_url=##DESCRIPTION_URL_UNESC##&correlator=##CACHEBUSTER##&cust_params=mm_midroll%3D##MIDROLL_ORDER##%26video_ID%3D##VIDEO_ID##"},"sponsorship":false,"player_identifier":"mplayer","recommendation_id":null,"brand_color":"#FF9900","powered_by_strip":true,"platform":"buffy","type":"video","config_name":"MM+ | Smithsonianmag | Podding","player_id":"3v9g2u2f","playlist_id":"fSkmeWKF","playback_method":"autoplay","anchor_viewability_method":"none","player_version":"v4","playlist_type":"semantic","semantic_options":{"scan_images_on_page":true,"scanned_element":"","tags":"geogrophy,nature,animals,habitat,outdoors,science,history","minimum_date_factor":30,"scanned_element_type":"tag","scoped_keywords":"mentalfloss","promoted_videos":[]},"script_destination":"mm","publisher_contribution":"floor8","general_script_description":"","brand_logo":"","brand_logo_click_url":"","next_video":"none","uniq_key":"af93e181-b289-0560-a2bf-808e93bb05bc","content_id":"fSkmeWKF","content_type":"semantic"})); Finland has vastly improved in reading, math and science literacy over the past decade in large part because its teachers are trusted to do whatever it takes to turn young lives around. This 13-year-old, Besart Kabashi, received something akin to royal tutoring. “I took Besart on that year as my private student,” Louhivuori told me in his office, which boasted a Beatles “Yellow Submarine” poster on the wall and an electric guitar in the closet. When Besart was not studying science, geography and math, he was parked next to Louhivuori’s desk at the front of his class of 9- and 10-year- olds, cracking open books from a tall stack, slowly reading one, then another, then devouring them by the dozens. By the end of the year, the son of Kosovo war refugees had conquered his adopted country’s vowel-rich language and arrived at the realization that he could, in fact, learn. Years later, a 20-year-old Besart showed up at Kirkkojarvi’s Christmas party with a bottle of Cognac and a big grin. “You helped me,” he told his former teacher. Besart had opened his own car repair firm and a cleaning company. “No big fuss,” Louhivuori told me. “This is what we do every day, prepare kids for life.” This tale of a single rescued child hints at some of the reasons for the tiny Nordic nation’s staggering record of education success, a phenomenon that has inspired, baffled and even irked many of America’s parents and educators. Finnish schooling became an unlikely hot topic after the 2010 documentary film Waiting for “Superman” contrasted it with America’s troubled public schools. “Whatever it takes” is an attitude that drives not just Kirkkojarvi’s 30 teachers, but most of Finland’s 62,000 educators in 3,500 schools from Lapland to Turku—professionals selected from the top 10 percent of the nation’s graduates to earn a required master’s degree in education. Many schools are small enough so that teachers know every student. If one method fails, teachers consult with colleagues to try something else. They seem to relish the challenges. Nearly 30 percent of Finland’s children receive some kind of special help during their first nine years of school. The school where Louhivuori teaches served 240 first through ninth graders last year; and in contrast with Finland’s reputation for ethnic homogeneity, more than half of its 150 elementary-level students are immigrants—from Somalia, Iraq, Russia, Bangladesh, Estonia and Ethiopia, among other nations. “Children from wealthy families with lots of education can be taught by stupid teachers,” Louhivuori said, smiling. “We try to catch the weak students. It’s deep in our thinking.” Advertisement scroll for more The transformation of the Finns’ education system began some 40 years ago as the key propellent of the country’s economic recovery plan. Educators had little idea it was so successful until 2000, when the first results from the Programme for International Student Assessment (PISA), a standardized test given to 15-year-olds in more than 40 global venues, revealed Finnish youth to be the best young readers in the world. Three years later, they led in math. By 2006, Finland was first out of 57 countries (and a few cities) in science. In the 2009 PISA scores released last year, the nation came in second in science, third in reading and sixth in math among nearly half a million students worldwide. “I’m still surprised,” said Arjariita Heikkinen, principal of a Helsinki comprehensive school. “I didn’t realize we were that good.” In the United States, which has muddled along in the middle for the past decade, government officials have attempted to introduce marketplace competition into public schools. In recent years, a group of Wall Street financiers and philanthropists such as Bill Gates have put money behind private-sector ideas, such as vouchers, data-driven curriculum and charter schools, which have doubled in number in the past decade. President Obama, too, has apparently bet on compe­tition. His Race to the Top initiative invites states to compete for federal dollars using tests and other methods to measure teachers, a philosophy that would not fly in Finland. “I think, in fact, teachers would tear off their shirts,” said Timo Heikkinen, a Helsinki principal with 24 years of teaching experience. “If you only measure the statistics, you miss the human aspect.”

      The facts show that America has it all wrong in putting to much emphasis on national "data-driven" competition. These approaches take away from the unique aspects of each child.

    2. t was the end of term at Kirkkojarvi Comprehensive School in Espoo, a sprawling suburb west of Helsinki, when Kari Louhivuori, a veteran teacher and the school’s principal, decided to try something extreme—by Finnish standards. One of his sixth-grade students, a Kosovo-Albanian boy, had drifted far off the learning grid, resisting his teacher’s best efforts. The school’s team of special educators—including a social worker, a nurse and a psychologist—convinced Louhivuori that laziness was not to blame. 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t="midroll".concat(e.midrollNumber);return r.adTagGenerator.generate(t,e.mediaId)}),f()(this,"generatePrerollTag",function(e,t){var n="preroll".concat(t);return r.adTagGenerator.generate(n,e)}),f()(this,"onAdTimeReached",function(){r.monetization.onMidrollAdOpportunity()}),f()(this,"onPreAdTimeReached",function(e){r.onPreMidrollAdOpportunity(e)}),f()(this,"onSeekToAdOpportunity",function(e){r.onPreMidrollAdOpportunity(e)}),f()(this,"isMidrollAlreadyRequested",function(e){return e.midrollNumber===r.lastRequestedMidroll.midrollNumber&&e.mediaId===r.lastRequestedMidroll.mediaId&&e.midrollTime===r.lastRequestedMidroll.midrollTime}),f()(this,"onPreMidrollAdOpportunity",function(e){if(Un(r.lastRequestedMidroll)||!r.isMidrollAlreadyRequested(e)){r.lastRequestedMidroll=e;var t=r.generateMidrollTag(e);r.monetization.onPreMidrollAdOpportunity(e,t)}}),f()(this,"onPrerollReached",function(e,t){var n=r.generatePrerollTag(e,t);r.monetization.onPrerollAdOpportunity(n)}),f()(this,"onSeekedWhileAdInProgress",function(){r.monetization.onMidrollAdOpportunity()});var i=t.getState;this.monetization=n,this.videoTimeSubscriber=new qi(t,this),this.videoSeekSubscriber=new zi(t,this),this.prerollScheduler=new Gi(t,this);var o=_i.adTagUrlTemplate(i());this.adTagGenerator=new Wi(o)},Yi=function(){function e(){Ai()(this,e)}return Vi()(e,null,[{key:"generateAdRequest",value:function(e,t,n){var r=new google.ima.AdsRequest;return r.adTagUrl=e,Fn()||r.setAdWillPlayMuted(t),r.vastLoadTimeout=n,r}}]),e}(),Zi=function(e){return function(t){t({type:"[MONETIZATION] change ad status",payload:e})}},Xi=function(e){return function(t){t({type:"[COMMON] set pending video status",payload:{pendingStatusObject:{type:e,value:""}}})}},Ji=function(e){return function(t){t({type:"[MONETIZATION] change loading ad status",payload:e})}},Qi=function(e){return function(t){t({type:"[MONETIZATION] update ad muted",payload:e})}},eo=function(e){return function(t){t({type:"[MONETIZATION] change ad volume",payload:e})}},to=function e(t,n,r,i,o){var a=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"IMAAdManager",void 0),f()(this,"adsLoader",void 0),f()(this,"adDisplayContainer",void 0),f()(this,"adVideoElement",void 0),f()(this,"videoPlayerElement",void 0),f()(this,"adContainerElement",void 0),f()(this,"anchorStatusStoreSubscriber",void 0),f()(this,"totalAdRequestMadeAmount",0),f()(this,"registerForWindowResize",function(){var e=zn(a.onResize.bind(a),80);window.addEventListener("resize",e)}),f()(this,"initMutationObserver",function(e){new MutationObserver(a.onResize).observe(e,{attributes:!0,childList:!1,subtree:!1})}),f()(this,"loadNewAd",function(e,t){var n=a.store.dispatch;a.clearOldAdManagerIfExist();var r=a.createAdRequest(e);try{a.validateAdRequestCorrectness(r),a.adsLoader.requestAds(r),function(e,t){return function(n){n({type:"[MONETIZATION] change ad 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google.ima.AdsLoader(t),a.adsLoader.getSettings().setDisableCustomPlaybackForIOS10Plus(!0),a.adsLoader.getSettings().setVpaidMode(google.ima.ImaSdkSettings.VpaidMode[n]),a.adsLoader.addEventListener(google.ima.AdsManagerLoadedEvent.Type.ADS_MANAGER_LOADED,a.onIMAAdsManagerLoaded.bind(a),!1,a),a.adsLoader.addEventListener(google.ima.AdErrorEvent.Type.AD_ERROR,a.onAdError.bind(a),!1,a)}),f()(this,"createAdRequest",function(e){var t=a.store.getState,n=gn.muted(t()),r=bi.adRequestTimeout(t());return Yi.generateAdRequest(e,n,r)}),f()(this,"validateAdRequestCorrectness",function(e){e&&e.adTagUrl&&decodeURIComponent(e.adTagUrl.replace(/\+/g," "))}),f()(this,"getLoadingError",function(e){var t=function(){return"bad ad request ".concat(JSON.stringify(e))};return{getError:function(){return{getMessage:t}}}}),f()(this,"getPlayAdError",function(e){var t=function(){return"play ad error: 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t=a.store,n=t.getState,r=t.dispatch,i=gn.volume(n());Bn()||gn.muted(n())?(e.setVolume(0),Qi(!0)(r)):(e.setVolume(gn.volume(n())),eo(i)(r),Qi(!1)(r))}),f()(this,"createIMAAdManager",function(t){a.IMAAdManager=t.getAdsManager(a.adVideoElement,e.getAdsRenderingSettings()),a.setAdVolume(a.IMAAdManager)}),f()(this,"registerToAdManagerEvents",function(){a.IMAAdManager.addEventListener(google.ima.AdErrorEvent.Type.AD_ERROR,a.onAdError),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.CONTENT_PAUSE_REQUESTED,a.onContentPauseRequested),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.CONTENT_RESUME_REQUESTED,a.onContentResumeRequested),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.STARTED,a.onAdStarted),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.IMPRESSION,a.onAdImpression),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.SKIPPED,a.onAdSkipped),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.COMPLETE,a.onAdCompleted),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.PAUSED,a.onAdPaused),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.RESUMED,a.onAdStarted),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.AD_PROGRESS,a.onAdProgressChanged),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.VOLUME_CHANGED,a.onVolumeChanged),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.VOLUME_MUTED,a.onAdVolumeMutedChanged),a.IMAAdManager.addEventListener(google.ima.AdEvent.Type.ALL_ADS_COMPLETED,a.onAdCompleted)}),f()(this,"onIMAAdsManagerLoaded",function(e){var t=a.store.dispatch;a.createIMAAdManager(e),a.registerToAdManagerEvents(),Zi("loaded")(t)}),f()(this,"onAdError",function(e){var t=a.store.dispatch;!function(e){return function(t){t({type:"[MONETIZATION] change ad error",payload:e})}}(e.getError().getMessage())(t),Ji(!1),a.continuePlayingContent()}),f()(this,"onAdImpression",function(e){var t=a.store.dispatch,n=!e.getAd().g.vpaid;a.setPodInfo(e),function(e){e({type:"[MONETIZATION] increase ad impression counter"})}(t),function(e){return function(t){t({type:"[MONETIZATION] update is vast ad",payload:e})}}(n)(t)}),f()(this,"onVolumeChanged",function(e){var t=a.store.dispatch;eo(e.target.getVolume())(t)}),f()(this,"onAdVolumeMutedChanged",function(e){var t=a.store.dispatch;0===e.target.getVolume()?Qi(!0)(t):Qi(!1)(t)}),f()(this,"continuePlayingContent",function(){var e=a.store,t=e.getState,n=e.dispatch,r=hn.videoTagStatus(t());Xi("idle"===r?"play":"resume")(n)}),f()(this,"stopPlayingContent",function(){var e=a.store.dispatch;Xi("pause")(e)}),f()(this,"onContentPauseRequested",function(){a.stopPlayingContent()}),f()(this,"onContentResumeRequested",function(){a.continuePlayingContent()}),f()(this,"onAdPaused",function(){var e=a.store.dispatch;Zi("paused")(e)}),f()(this,"setPodInfo",function(e){var t=e&&e.getAd()&&e.getAd().getAdPodInfo();if(!Un(t)){var n=a.store.dispatch;!function(e,t){return function(n){n({type:"[MONETIZATION] change pod info",payload:{slotNumber:e,podNumber:t}})}}(t.getAdPosition(),a.totalAdRequestMadeAmount)(n)}}),f()(this,"onAdStarted",function(){var e=a.store,t=e.dispatch,n=e.getState,r=gn.volume(n());Zi("playing")(t),0===a.IMAAdManager.getVolume()?a.IMAAdManager.setVolume(0):window.shouldPlayAdRule||a.IMAAdManager.setVolume(r),a.onResize()}),f()(this,"onAdCompleted",function(){var e=a.store.dispatch;Zi("completed")(e)}),f()(this,"onAdSkipped",function(){var e=a.store.dispatch;Zi("skipped")(e)}),f()(this,"onResize",function(){Un(a.IMAAdManager)||(a.IMAAdManager.resize(a.videoPlayerElement.clientWidth,a.videoPlayerElement.clientHeight,google.ima.ViewMode.NORMAL),a.adContainerElement.style.height="".concat(a.videoPlayerElement.clientHeight,"px"))}),f()(this,"onAdProgressChanged",function(e){var t,n,r=a.store,i=r.dispatch,o=r.getState,s=e.getAdData().currentTime,u=e.getAdData().duration,c=_i.adDuration(o());(t=s,function(e){e({type:"[MONETIZATION] change ad current time",payload:t})})(i),c!==u&&(n=u,function(e){e({type:"[MONETIZATION] change ad duration",payload:n})})(i)}),f()(this,"onAnchorStatusChanged",function(){var e=a.store.getState;"processing"!==Pr(e())&&a.onResize()}),f()(this,"changeAdVolume",function(e){Un(a.IMAAdManager)||a.IMAAdManager.setVolume(e)}),f()(this,"changeAdMuted",function(e,t){Un(a.IMAAdManager)||(t?a.IMAAdManager.setVolume(0):a.IMAAdManager.setVolume(e))}),f()(this,"changeAdStatus",function(e){Un(a.IMAAdManager)||("playing"===e&&a.IMAAdManager.resume(),"paused"===e&&a.IMAAdManager.pause())});var s=t.getState;this.store=t,this.adVideoElement=r,this.videoPlayerElement=i,this.adContainerElement=n,this.adDisplayContainer=new google.ima.AdDisplayContainer(n,r),this.createAdLoader(s(),this.adDisplayContainer),this.adDisplayContainer.initialize(),this.anchorStatusStoreSubscriber=new ji(t,e.getAnchorDependencies,this.onAnchorStatusChanged.bind(this)),this.registerForWindowResize(),this.initMutationObserver(o)};f()(to,"getAdsRenderingSettings",function(){var e=new google.ima.AdsRenderingSettings;return e.restoreCustomPlaybackStateOnAdBreakComplete=!0,e.enablePreloading=!1,e.uiElements=[],e.loadVideoTimeout=15e3,e}),f()(to,"getAnchorDependencies",function(e){return[Pr(e)]});var no=function e(t,n,r,i,o,a){var s=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"playerId",void 0),f()(this,"adScheduler",void 0),f()(this,"adHandler",void 0),f()(this,"imaLoadingStatusSubscriber",void 0),f()(this,"adStatusSubscriber",void 0),f()(this,"videoTagStatusSubscriber",void 0),f()(this,"adContainer",void 0),f()(this,"adVideoElement",void 0),f()(this,"videoPlayerElement",void 0),f()(this,"playerContainer",void 0),f()(this,"pendingMidrollAdPlay",!1),f()(this,"pendingPrerollAdPlay",!1),f()(this,"pendingPrerollAdTag",null),f()(this,"pendingMidrollNumber",null),f()(this,"pendingAdStatusStoreSubscriber",void 0),f()(this,"adMutedStoreSubscriber",void 0),f()(this,"adVolumeStoreSubscriber",void 0),f()(this,"onMidrollAdOpportunity",function(){var e=s.store,t=e.dispatch,n=e.getState,r=_i.adStatus(n()),i=bi.continuePlayingWhileWaitingForAd(n());"loaded"===r?s.playAd(!0):"requested"===r&&(s.pendingMidrollAdPlay=!0,i||(Xi("pause")(t),Ji(!0)(t))),function(e){e({type:"[MONETIZATION] increase ad Opportunity counter"})}(t)}),f()(this,"onPrerollAdOpportunity",function(e){var t=s.store,n=t.getState,r=t.dispatch,i=Fi.loadingImaStatus(n());Un(s.adHandler)?"loading"!==i&&""!==i||(Ji(!0)(r),s.pendingPrerollAdPlay=!0,s.pendingPrerollAdTag=e):(s.pendingPrerollAdPlay=!0,Ji(!0)(r),s.adHandler.loadNewAd(e,"preroll"))}),f()(this,"onPreMidrollAdOpportunity",function(e,t){Un(s.adHandler)||(e.currentTime>=e.midrollTime&&(s.pendingMidrollAdPlay=!0),s.pendingMidrollNumber=e.midrollNumber,s.adHandler.loadNewAd(t,"midroll"))}),f()(this,"hasPendingAd",function(){return s.hasPendingMidrollAdPlay()||s.hasPendingPrerollAdPlay()}),f()(this,"onAdStatusChanged",function(e){var t=s.store.dispatch,n=_i.adStatus(e);"completed"===n&&Ji(!1)(t);var r=bi.continuePlayingWhileWaitingForAd(e),i=_i.loadingAd(e);"playing"!==n&&"error"!==n||r||!i||Ji(!1)(t),s.hasPendingAd()&&"loaded"===n?s.playAd(s.hasPendingMidrollAdPlay()):s.hasPendingAd()&&"error"===n?(Ji(!1),s.clearPendingMidroll(),s.clearPendingPreroll()):Hi(n)||(Ji(!1),function(e){e({type:"[MONETIZATION] clear ad data"})}(t))}),f()(this,"clearPendingMidroll",function(){s.pendingMidrollNumber=null,s.pendingMidrollAdPlay=!1}),f()(this,"clearPendingPreroll",function(){s.pendingPrerollAdPlay=!1,s.pendingPrerollAdTag=null}),f()(this,"onVideoTagStatusChanged",function(e){"complete"===hn.videoTagStatus(e)&&function(e){e({type:"[MONETIZATION] clear played midrolls"})}(s.store.dispatch)}),f()(this,"hasPendingMidrollAdPlay",function(){return s.pendingMidrollAdPlay}),f()(this,"hasPendingPrerollAdPlay",function(){return s.pendingPrerollAdPlay}),f()(this,"playAd",function(e){var t,n=s.store.dispatch,r=s.adHandler.playAd();e?((t=s.pendingMidrollNumber,function(e){e({type:"[MONETIZATION] add 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Ki(t,this),this.adStatusSubscriber=new ji(t,e.getAdStatusDependencies,this.onAdStatusChanged.bind(this)),this.videoTagStatusSubscriber=new ji(t,e.getVideoTagStatusDependencies,this.onVideoTagStatusChanged.bind(this)),e.canUseIMA(u())?this.adHandler=new to(t,r,i,o,a):this.imaLoadingStatusSubscriber=new ji(t,e.getIMALoadingStatusDependencies,this.onIMALoadingStatusChanged.bind(this)),this.pendingAdStatusStoreSubscriber=new ji(t,e.getPendingAdStatusDependencies,this.onPendingAdStatusChanged.bind(this)),this.adMutedStoreSubscriber=new ji(t,e.getAdMutedDependencies,this.onAdMutedChanged.bind(this)),this.adVolumeStoreSubscriber=new ji(t,e.getAdVolumeDependencies,this.onAdVolumeChanged.bind(this))};f()(no,"getAdStatusDependencies",function(e){return[_i.adStatus(e)]}),f()(no,"getVideoTagStatusDependencies",function(e){return[hn.videoTagStatus(e)]}),f()(no,"getIMALoadingStatusDependencies",function(e){return[Fi.loadingImaStatus(e)]}),f()(no,"canUseIMA",function(e){return"success"===Fi.loadingImaStatus(e)}),f()(no,"getPendingAdStatusDependencies",function(e){return[_i.pendingAdStatus(e)]}),f()(no,"getAdMutedDependencies",function(e){return[_i.adMuted(e)]}),f()(no,"getAdVolumeDependencies",function(e){return[_i.adVolume(e)]});var ro=function(e,t){!function(e,t){var n=document.getElementById(vn(t));B(b(Li,{store:e,playerId:t}),n)}(e,t);var n=function(e){var t=Ri(e);return document.getElementById(t)}(t),r=function(e){var t=Bn()?Di(e):En(e);return document.getElementById(t)}(t),i=function(e){var t=En(e);return document.getElementById(t)}(t),o=function(e){var t=bn(e);return document.getElementById(t)}(t);return new no(e,t,n,r,i,o)},io=n(4),oo=n.n(io),ao=n(7),so=n.n(ao),uo=function(){function e(){Ai()(this,e),f()(this,"duration",void 0),f()(this,"position",void 0),f()(this,"previousPosition",void 0),f()(this,"loadTime",void 0),f()(this,"adOrder",void 0),f()(this,"adType",void 0),f()(this,"adDuration",void 0),f()(this,"errorMessage",void 0),f()(this,"adPodNumber",void 0),f()(this,"adSlotNumber",void 0)}return Vi()(e,[{key:"setDuration",value:function(e){return this.duration=e,this}},{key:"setPosition",value:function(e){return this.position=e,this}},{key:"setPreviousPosition",value:function(e){return this.previousPosition=e,this}},{key:"setLoadTime",value:function(e){return this.loadTime=e,this}},{key:"setAdOrder",value:function(e){return this.adOrder=e,this}},{key:"setAdType",value:function(e){return this.adType=e,this}},{key:"setAdDuration",value:function(e){return this.adDuration=e,this}},{key:"setErrorMessage",value:function(e){return this.errorMessage=e,this}},{key:"setAdPodNumber",value:function(e){return this.adPodNumber=e,this}},{key:"setAdSlotNumber",value:function(e){return this.adSlotNumber=e,this}},{key:"build",value:function(){var e=[];return jn(this.position)||e.push("video current position=".concat(Hn(this.position),"sec")),jn(this.duration)||e.push("video duration time=".concat(Hn(this.duration),"sec")),jn(this.loadTime)||e.push("video load time=".concat(this.loadTime,"milliseconds")),jn(this.previousPosition)||e.push("previous position=".concat(Hn(this.previousPosition),"sec")),jn(this.adOrder)||e.push("ad order=".concat(this.adOrder)),jn(this.adType)||e.push("ad type=".concat(this.adType)),jn(this.adDuration)||e.push("ad duration=".concat(Hn(Number(this.adDuration)),"sec")),jn(this.adPodNumber)||e.push("pod number=".concat(this.adPodNumber)),jn(this.adSlotNumber)||e.push("slot number=".concat(this.adSlotNumber)),jn(this.errorMessage)||e.push("error message=".concat(this.errorMessage)),e.join(";")}}]),e}(),co="mmPlus GTM data ready to GA",lo="mmPlus GTM event to GA",po={EMBED:"vplayer video player embed",FIRST_PLAY:"vplayer video first play",COMPLETION_25_PERCENTAGE:"vplayer video 25% complete",COMPLETION_50_PERCENTAGE:"vplayer video 50% complete",COMPLETION_75_PERCENTAGE:"vplayer video 75% complete",COMPLETION_90_PERCENTAGE:"vplayer video 90% complete",AD_BLOCK:"vplayer video ad block",AD_REQUEST:"vplayer video ad request",AD_IMPRESSION:"vplayer video ad impression",AD_ERROR:"vplayer video ad error",AD_VIEWABLE_IMPRESSION:"vplayer video ad viewable impression",AD_COMPLETE:"vplayer video ad complete",AD_SKIP:"vplayer video ad skip",AD_PAUSE:"vplayer video ad pause",VIDEO_COMPLETE:"vplayer video complete",FULLSCREEN_ON:"vplayer video fullscreen on",FULLSCREEN_OFF:"vplayer video fullscreen off",SEEK:"vplayer video position seeked",VIDEO_MUTE:"vplayer video mute",VIDEO_UNMUTE:"vplayer video unmute",CONTROLS_MUTE_OR_UNMUTE:"controls 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t=gn.fullscreen(e),n=hn.currentVideoTimeFragment(e),i=(new uo).setPosition(n).build(),o=t?po.FULLSCREEN_ON:po.FULLSCREEN_OFF;r.analyticsEventsCallbacks.onEvent(o,i)}),this.store=t,this.analyticsEventsCallbacks=n,this.videoMuteSubscriber=new ji(t,e.getVideoMuteDependencies,this.onMuteStateChanged.bind(this)),this.videoFullscreenSubscriber=new ji(t,e.getVideoFullscreenDependencies,this.onFullsScreenStateChanged.bind(this))};f()(yo,"getVideoMuteDependencies",function(e){return[gn.muted(e)]}),f()(yo,"getVideoFullscreenDependencies",function(e){return[gn.fullscreen(e)]});var go=n(3),vo=n.n(go),mo=n(8),bo=n.n(mo),Oo=n(9),_o=n.n(Oo),So=n(5),Eo=n.n(So);n(20);var wo={root:null,threshold:.5,rootMargin:"0px"},Po=function(){function e(t,n,r){Ai()(this,e),f()(this,"store",void 0),f()(this,"observableElement",void 0),f()(this,"callback",void 0),f()(this,"isViewableTimeoutHandler",null),f()(this,"observer",void 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The initial state may not be undefined, but can be null.')})}(n)}catch(s){o=s}return function(e,t){if(void 0===e&&(e={}),o)throw o;for(var r=!1,i={},s=0;s<a.length;s++){var u=a[s],c=n[u],l=e[u],d=c(l,t);if("undefined"===typeof d){var p=mt(u,t);throw new Error(p)}i[u]=d,r=r||d!==l}return(r=r||a.length!==Object.keys(e).length)?i:e}}({dependenciesLoadingStatus:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:da,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] update hls status":return la(la({},e),{},{loadingHLSStatus:t.payload});case"[CORE] update ima status":return la(la({},e),{},{loadingImaStatus:t.payload});default:return e}},playerData:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:ha,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":var n=t.payload;return fa({},function(e,t,n){var r=t.playback_method,i=t.player_id;return fa(fa({},e),{},{playbackMethod:Un(r)?e.playbackMethod:r,playerId:Un(i)?e.playerId:i,playerInstanceUniqId:n,playerMode:Fn()?"mobile":"desktop"})}(e,n.initiateParams,n.playerInstanceUniqId));case"[CORE] reset player data time params":return fa(fa({},e),{},{currentVideoTimeFragment:0,currentVideoBufferedTime:0,currentVideoDuration:0,currentVideoTime:0});case"[COMMON] set mute video":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{muted:t.payload})});case"[COMMON] set volume":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{volume:t.payload})});case"[COMMON] change selected settings category":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{selectedSettingsCategory:t.payload})});case"[COMMON] change settings speed":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{speed:t.payload})});case"[COMMON] change settings quality":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{quality:t.payload})});case"[COMMON] set fullscreen":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{fullscreen:fa(fa({},e.playerSettings.fullscreen),{},{isFullscreenOn:t.payload,pendingFullscreenRequest:""})})});case"[COMMON] set fullscreen request":return fa(fa({},e),{},{playerSettings:fa(fa({},e.playerSettings),{},{fullscreen:fa(fa({},e.playerSettings.fullscreen),{},{pendingFullscreenRequest:t.payload})})});case"[COMMON] set pending video status":var r=t.payload.pendingStatusObject;return fa(fa({},e),{},{pendingVideoTagStatus:fa({},r)});case"[COMMON] set player mode":return fa(fa({},e),{},{playerMode:t.payload});case"[CORE] update video current fragment position":return fa(fa({},e),{},{currentVideoTimeFragment:t.payload});case"[CORE] update video current position":return fa(fa({},e),{},{currentVideoTime:t.payload});case"[CORE] update video current buffered time":return fa(fa({},e),{},{currentVideoBufferedTime:t.payload});case"[CORE] update video current duration":return fa(fa({},e),{},{currentVideoDuration:t.payload});case"[CORE] change video tag status":return fa(fa({},e),{},{videoTagStatus:t.payload});case"[CORE] update player visibility":return fa(fa({},e),{},{playerVisibility:t.payload});case"[CORE] update placeholder visibility":return fa(fa({},e),{},{playerPlaceholderVisibility:t.payload});case"[CORE] change loading player status":return fa(fa({},e),{},{loadingPlayer:t.payload});case"[COMMON] show black screen with loader":return fa(fa({},e),{},{loader:fa(fa({},e.loader),{},{showBlackScreen:t.payload})});case"[CORE] set player size":return fa(fa({},e),{},{playerSize:t.payload});case"[COMMON] set error message":return fa(fa({},e),{},{errorMessage:t.payload});default:return e}},brandingData:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:va,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return ga({},function(e,t){var n=t.powered_by_strip,r=t.brand_logo,i=t.brand_logo_click_url,o=t.brand_color;return ga(ga({},e),{},{showVoltaxLogo:Un(n)?e.showVoltaxLogo:n,brandingLogoSrc:Un(r)?e.brandingLogoSrc:r,brandingLogoUrl:Un(i)?e.brandingLogoUrl:i,brandingColor:Un(o)?e.brandingColor:o})}(e,t.payload.initiateParams));default:return e}},anchorOptions:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Oa,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return ba({},function(e,t){var n=t.anchor_options;if(!Un(n)){var r=n.anchoring_appearance,i=n.can_close,o=n.closable_ad,a=n.close_after,s=n.continue_streaming,u=n.orientation,c=n.margins,l=n.sticky_below_class_name,d=n.width,p=Un(c)?e.margins:{top:Number.isInteger(c.top)?c.top:e.margins.top,bottom:Number.isInteger(c.bottom)?c.bottom:e.margins.bottom,left:Number.isInteger(c.left)?c.left:e.margins.left,right:Number.isInteger(c.right)?c.right:e.margins.right};return ba(ba({},e),{},{anchoringAppearance:r||e.anchoringAppearance,canClose:Un(i)?e.canClose:i,orientation:Un(u)?e.orientation:u,closableAd:Un(o)?e.closableAd:o,closeAfter:Un(a)?e.closeAfter:a,continueStreaming:Un(s)?e.continueStreaming:s,stickyBelowClassName:Un(l)?e.stickyBelowClassName:l,width:Un(d)?e.width:d,margins:p,anchorData:ba(ba({},e.anchorData),{},{anchorEnabled:!0})})}return e}(e,t.payload.initiateParams));case"[COMMON] set anchor enable":return ba(ba({},e),{},{anchorData:ba(ba({},e.anchorData),{},{anchorEnabled:t.payload})});case"[ANCHOR] update is anchor status":return ba(ba({},e),{},{anchorData:ba(ba({},e.anchorData),{},{anchorStatus:t.payload})});case"[COMMON] set anchor disabled by user":return ba(ba({},e),{},{anchorData:ba(ba({},e.anchorData),{},{anchorDisabledByUser:t.payload})});default:return e}},monetization:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:wa,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Sa({},function(e,t){var n=t.monetization;if(Un(n))return e;var r=n.ad_tag,i=n.ad_type,o=n.vpaid_mode,a=n.ad_request_timeout,s=n.continue_content_play_while_waiting_for_ad,u=n.midrolls,c=u&&u.on&&u.on.sort(Wn),l=Un(s)?e.continuePlayingWhileWaitingForAd:s,d=c?c.indexOf(0):-1,p=-1!==d&&!l;return p&&(c=c.splice(d,1)),Sa(Sa({},e),{},{midrolls:Sa(Sa({},e.midrolls),{},{every:u&&u.every,on:c}),prerollEnabled:p,adRequestTimeout:Un(a)?e.adRequestTimeout:parseInt(a,10),vpaidMode:Un(o)?e.vpaidMode:o,continuePlayingWhileWaitingForAd:l,adsData:Sa(Sa({},e.adsData),{},{adType:Un(i)?e.adsData.adType:i,adTagUrlTemplate:Un(r)?e.adsData.adTagUrlTemplate:r})})}(e,t.payload.initiateParams));case"[COMMON] set new ad tag url template":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adTagUrlTemplate:t.payload})});case"[MONETIZATION] change ad status":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adStatus:t.payload,adErrorMessage:null})});case"[MONETIZATION] change ad tag":var n=t.payload,r=n.adUnit,i=n.adTag;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{currentAdTag:i,adUnit:r})});case"[MONETIZATION] change pending ad status":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{pendingAdStatus:t.payload})});case"[MONETIZATION] change ad error":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adStatus:"error",adErrorMessage:t.payload})});case"[MONETIZATION] increase ad impression counter":var o=e.adsData.adImpression;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adImpression:o+1})});case"[MONETIZATION] increase ad Opportunity counter":var a=e.adsData.adOpportunity;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adOpportunity:a+1})});case"[MONETIZATION] add played midroll number":var s=e.adsData.playedMidrolls,u=In()(s);return u.push(t.payload),Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adOrder:t.payload,playedMidrolls:u})});case"[MONETIZATION] clear played midrolls":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{playedMidrolls:[]})});case"[MONETIZATION] clear ad data":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adOrder:0,currentAdTag:null,adDuration:0,adUnit:""})});case"[MONETIZATION] change ad duration":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adDuration:t.payload})});case"[MONETIZATION] update is vast ad":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{isVastAd:t.payload})});case"[MONETIZATION] change ad current time":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adCurrentTime:t.payload})});case"[MONETIZATION] update ad muted":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adMuted:t.payload})});case"[MONETIZATION] change ad volume":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{adVolume:t.payload})});case"[MONETIZATION] change pod info":var c=t.payload,l=c.podNumber,d=c.slotNumber;return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{podNumber:l,slotNumber:d})});case"[MONETIZATION] change loading ad status":return Sa(Sa({},e),{},{adsData:Sa(Sa({},e.adsData),{},{loadingAd:t.payload})});default:return e}},mediaData:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:ja,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Va({},function(e,t){var n=t.content_type,r=t.media_id,i=t.display_title;return Va(Va({},e),{},{mediaType:Un(n)?e.mediaType:n,mediaId:Un(r)?e.mediaId:r,videoData:Va(Va({},e.videoData),{},{showTitle:!!Un(i)||i})})}(e,t.payload.initiateParams));case"[CORE] load video request":return Va(Va({},e),{},{loadingMedia:!0});case"[CORE] load video request success":return Va(Va({},e),{},{loadingMedia:!1,videoList:t.payload});case"[CORE] set current video":var n=t.payload,r=n.index,i=n.videoData;return Va(Va({},e),{},{activeVideoIndex:r,videoData:i});case"[CORE] load video request error":return Va(Va({},e),{},{loadingMedia:!1,mediaLoadingError:t.payload});case"[COMMON] media request":var o=t.payload.mediaRequestObject;return Va(Va({},e),{},{mediaRequest:Va({},o)});default:return e}},semanticOptions:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Ba,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Fa({},function(e,t){var n=t.semantic_options;if(Un(n))return e;var r=n.minimum_date_factor,i=n.promoted_videos,o=n.scan_images_on_page,a=n.scanned_element,s=n.scanned_element_type,u=n.scoped_keywords,c=n.tags;return Fa(Fa({},e),{},{minimumDateFactor:Un(r)?e.minimumDateFactor:r,promotedVideos:Un(i)?e.promotedVideos:i,scanImagesOnPage:Un(o)?e.scanImagesOnPage:o,scannedElement:Un(a)?e.scannedElement:a,scannedElementType:Un(s)?e.scannedElementType:s,scopedKeywords:Un(u)?e.scopedKeywords:u,tags:Un(c)?e.tags:c})}(e,t.payload.initiateParams));default:return e}},userInteraction:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Wa,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[USER INTERACTION] change user interaction":return qa(qa({},e),{},{userInteractionType:t.payload});default:return e}},splitView:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:$a,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Ga({},function(e,t){var n=t.anchor_options;if(!Un(n)){var r=n.split_view,i=n.split_view_ratio;return Ga(Ga({},e),{},{splitViewRatio:Un(r)||!r||Un(i)?e.splitViewRatio:i})}return e}(e,t.payload.initiateParams));default:return e}},discovery:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:Za,t=arguments.length>1?arguments[1]:void 0;switch(t.type){case"[CORE] initiate store":return Ya({},function(e,t){var n=t.next_video;return Un(n)?e:Ya(Ya({},e),{},{nextVideo:Xa(n)})}(e,t.payload.initiateParams));case"[DISCOVERY] show up next":return Ya(Ya({},e),{},{showUpNext:t.payload});case"[DISCOVERY] show skippable content":return Ya(Ya({},e),{},{showSkippableContent:t.payload});default:return e}}}),Qa=[],es=!1,ts=function e(){return function(t){return function(n){if(es)return Qa.push(n),null;es=!0;var r=t(n);return es=!1,Qa.length>0&&e()(t)(Qa.shift()),r}}},ns=function(e){var t=[];if(function(e){return!Un(e)&&!Un(e.enable_redux_debugging)&&e.enable_redux_debugging}(e)){var n=window&&window.__REDUX_DEVTOOLS_EXTENSION__&&window.__REDUX_DEVTOOLS_EXTENSION__();"function"===typeof n&&t.push(n)}var r=Et.apply(void 0,[wt(ua,ts)].concat(t));return vt(Ja,r)},rs=function(){function e(t){Ai()(this,e),f()(this,"playerVisibilitySubscriber",void 0),f()(this,"videoTagStatusSubscriber",void 0),f()(this,"shouldPlayIfLazyplay",!0),f()(this,"shouldPlayIfAutoplayWhenViewable",!0),f()(this,"videoPausedByObserver",!1),this.store=t,this.playerVisibilitySubscriber=null,this.videoTagStatusSubscriber=null,this.playAccordingToPlaybackMethod()}return Vi()(e,[{key:"lazyplayHandler",value:function(e){hn.playerVisibility(e)>=.5&&(this.playVideo(),this.shouldPlayIfLazyplay=!1)}},{key:"autoplayWhenViewableHandler",value:function(e){hn.playerVisibility(e)>=.5?this.playVideo():this.pauseVideo()}},{key:"onPlayerVisibilityChanged",value:function(e){var t=hn.playbackMethod(e);"lazyplay"===t&&this.shouldPlayIfLazyplay&&this.lazyplayHandler(e),"autoplay_when_viewable"===t&&this.shouldPlayIfAutoplayWhenViewable&&this.autoplayWhenViewableHandler(e)}},{key:"onVideoTagStatusChanged",value:function(e){var t=hn.videoTagStatus(e);"paused"!==t||this.videoPausedByObserver||(this.shouldPlayIfAutoplayWhenViewable=!1),"playing"===t&&(this.shouldPlayIfAutoplayWhenViewable=!0,this.videoPausedByObserver=!1)}},{key:"initiatePlayerVisibilitySubscriber",value:function(){this.playerVisibilitySubscriber=new ji(this.store,e.getPlayerVisibilityDependencies,this.onPlayerVisibilityChanged.bind(this))}},{key:"initiateVideoTagStatusSubscriber",value:function(){this.videoTagStatusSubscriber=new ji(this.store,e.getVideoTagStatusDependencies,this.onVideoTagStatusChanged.bind(this))}},{key:"playVideo",value:function(){var e=this.store,t=e.dispatch,n=e.getState;"idle"===hn.videoTagStatus(n())?on("play")(t):on("resume")(t)}},{key:"pauseVideo",value:function(){var e=this.store,t=e.dispatch,n=e.getState;"paused"!==hn.videoTagStatus(n())&&(this.videoPausedByObserver=!0,on("pause")(t))}},{key:"playAccordingToPlaybackMethod",value:function(){var e=this.store,t=e.dispatch,n=(0,e.getState)();switch(hn.playbackMethod(n)){case"autoplay":this.playVideo();break;case"lazyplay":this.initiatePlayerVisibilitySubscriber();break;case"autoplay_when_viewable":this.initiatePlayerVisibilitySubscriber(),this.initiateVideoTagStatusSubscriber();break;case"none":an(!1)(t)}}}],[{key:"getPlayerVisibilityDependencies",value:function(e){return[hn.playerVisibility(e)]}},{key:"getVideoTagStatusDependencies",value:function(e){return[hn.videoTagStatus(e)]}}]),e}(),is=function(){function e(t,n,r,i){var o=this;Ai()(this,e),f()(this,"videoStatusSubscriber",void 0),f()(this,"videoListSubscriber",void 0),f()(this,"mediaRequestSubscriber",void 0),f()(this,"playerVisibilitySubscriber",void 0),f()(this,"playbackMethodManager",void 0),f()(this,"store",void 0),f()(this,"loadContent",function(e,t,n,r){o.loadMedia(t,n,r).then(function(){o.playbackMethodManager=new rs(e)})}),f()(this,"loadMedia",function(e,t,n){var r=o.store,i=r.dispatch,a=r.getState,s=Dn.showTitle(a());if("semantic"===e){var u=pn.semanticOptions(a());return Na(u,s,n)(i)}return ka(t,s,n)(i)}),this.store=t,this.videoStatusSubscriber=new ji(t,e.getVideoStatusDependencies,this.onVideoStatusChanged.bind(this)),this.videoListSubscriber=new ji(t,e.getVideoListDependencies,this.onVideoListChanged.bind(this)),this.mediaRequestSubscriber=new ji(t,e.getMediaRequestDependencies,this.onMediaRequestChanged.bind(this)),this.playerVisibilitySubscriber=null,this.loadContent(t,r,n,i)}return Vi()(e,null,[{key:"createInstance",value:function(t,n,r,i){return new e(t,n,r,i)}}]),Vi()(e,[{key:"playNextVideo",value:function(e){var t=this.store.dispatch,n=Cn.videoList(e),r=Cn.activeVideoIndex(e)+1;n.length>1&&r>=n.length&&(r=0),r<n.length&&(!function(e){e({type:"[CORE] reset player data time params"})}(t),La(r,n[r])(t),on("play")(t))}},{key:"playPreviousVideo",value:function(e){var t=this.store.dispatch,n=Cn.videoList(e),r=Cn.activeVideoIndex(e);if(r>0){var i=r-1;La(i,n[i])(t),on("play")(t)}}},{key:"onVideoStatusChanged",value:function(e){"complete"===hn.videoTagStatus(e)&&this.playNextVideo(e)}},{key:"onVideoListChanged",value:function(e){var t=this.store.dispatch,n=Cn.videoList(e);!jn(n)&&n.length>0&&La(0,n[0])(t)}},{key:"onMediaRequestChanged",value:function(e){var t=Cn.mediaRequest(e);switch(t.type){case"playNewVideo":this.loadMedia("specific",t.value);break;case"playNextVideo":this.playNextVideo(e);break;case"playPreviousVideo":this.playPreviousVideo(e)}}}],[{key:"getVideoStatusDependencies",value:function(e){return[hn.videoTagStatus(e)]}},{key:"getVideoListDependencies",value:function(e){return[Cn.videoList(e)]}},{key:"getMediaRequestDependencies",value:function(e){return[Cn.mediaRequest(e)]}}]),e}(),os=function e(t){var n=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"onDependencyFailure",function(e,t){console.log("onDependencyFailure",e,t);var r=n.store,i=r.dispatch,o=r.getState;switch(e){case"ima":"blocked"!==Fi.loadingImaStatus(o())&&Qn("error")(i);break;case"hls":er("error")(i)}}),f()(this,"onDependencyReady",function(e){var t=n.store.dispatch;switch(e){case"ima":Qn("success")(t);break;case"hls":er("success")(t)}}),this.store=t},as=function(e){return function(t){t({type:"[COMMON] set fullscreen",payload:e})}},ss=function(){function e(t,n){var r=this;Ai()(this,e),f()(this,"store",void 0),f()(this,"videoTag",void 0),f()(this,"pendingFullscreenSubscriber",void 0),f()(this,"adStatusSubscriber",void 0),f()(this,"playerUniqId",void 0),f()(this,"onAdStatusChanged",function(e){var t=_i.adStatus(e),n=r.videoTag.webkitDisplayingFullscreen;"playing"===t&&Bn()&&n&&r.exitFullscreen(r.videoTag)}),f()(this,"isPlayerInFullscreen",function(){var e=document,t=Bn()?En(r.playerUniqId):bn(r.playerUniqId);return Un(e.fullscreenElement)?!Un(e.webkitFullscreenElement)&&0===e.webkitFullscreenElement.id.localeCompare(t):0===e.fullscreenElement.id.localeCompare(t)}),f()(this,"changePlayerWidth",function(e){r.videoTag.style.width=e?"100%":"auto"}),f()(this,"onFullscreenChanged",function(){var e=r.store.dispatch,t=r.isPlayerInFullscreen();r.changePlayerWidth(t),as(t)(e)}),f()(this,"onFullscreenChangedIos",function(){var e=r.store.dispatch,t=r.videoTag.webkitDisplayingFullscreen;t||on("resume")(e),r.changePlayerWidth(t),as(t)(e)}),f()(this,"onPendingFullscreenRequestChanged",function(e){var t=gn.pendingFullscreenRequest(e);"enter"===t?r.enterFullscreen(r.videoTag):"exit"===t&&r.exitFullscreen(r.videoTag)}),f()(this,"getFullScreenElement",function(e,t){var n=document.getElementById(bn(r.playerUniqId));return Bn()?t:e?document:n}),f()(this,"enterFullscreen",function(e){var t=r.getFullScreenElement(!1,e);Bn()?t.webkitEnterFullscreen():document.webkitExitFullscreen?t.webkitRequestFullscreen():document.webkitCancelFullScreen?t.webkitRequestFullScreen():document.mozCancelFullScreen?t.mozRequestFullScreen():document.msExitFullscreen&&t.msRequestFullscreen()}),f()(this,"exitFullscreen",function(e){var t=r.getFullScreenElement(!0,e);document.webkitExitFullscreen||Bn()?t.webkitExitFullscreen():document.webkitCancelFullScreen?t.webkitCancelFullScreen():document.mozCancelFullScreen?t.mozCancelFullScreen():document.msExitFullscreen&&t.msExitFullscreen()}),this.store=t,this.videoTag=document.getElementById(En(n)),this.playerUniqId=n,document.addEventListener("fullscreenchange",this.onFullscreenChanged.bind(this)),document.addEventListener("webkitfullscreenchange",this.onFullscreenChanged.bind(this)),Bn()&&(this.videoTag.addEventListener("webkitendfullscreen",this.onFullscreenChangedIos.bind(this)),this.videoTag.addEventListener("webkitbeginfullscreen",this.onFullscreenChangedIos.bind(this))),this.pendingFullscreenSubscriber=new ji(t,e.getPendingFullscreenDependencies,this.onPendingFullscreenRequestChanged.bind(this)),this.adStatusSubscriber=new ji(t,e.getAdStatusDependencies,this.onAdStatusChanged.bind(this))}return Vi()(e,null,[{key:"createInstance",value:function(t,n){return new e(t,n)}}]),Vi()(e,null,[{key:"getPendingFullscreenDependencies",value:function(e){return[gn.pendingFullscreenRequest(e)]}},{key:"getAdStatusDependencies",value:function(e){return[_i.adStatus(e)]}}]),e}();function us(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter(function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable})),n.push.apply(n,r)}return n}function cs(e){for(var t=1;t<arguments.length;t++){var n=null!=arguments[t]?arguments[t]:{};t%2?us(Object(n),!0).forEach(function(t){f()(e,t,n[t])}):Object.getOwnPropertyDescriptors?Object.defineProperties(e,Object.getOwnPropertyDescriptors(n)):us(Object(n)).forEach(function(t){Object.defineProperty(e,t,Object.getOwnPropertyDescriptor(n,t))})}return e}var ls,ds=function(e){return function(e){return e&&window.monti.playerConfigs&&window.monti.playerConfigs[e]}(e)?function(e){return 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ji(t,e.getHLSLoadingStatusDependencies,this.onHlsLoadingStatusChanged.bind(this))}return Vi()(e,null,[{key:"createInstance",value:function(t,n){return new e(t,n)}}]),Vi()(e,null,[{key:"getHLSLoadingStatusDependencies",value:function(e){return[Fi.loadingHLSStatus(e)]}},{key:"getPendingVideoStatusDependencies",value:function(e){return[hn.pendingVideoTagStatus(e)]}},{key:"getVideoDataDependencies",value:function(e){return[Cn.videoData(e)]}}]),e}();function ms(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter(function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable})),n.push.apply(n,r)}return n}function bs(e){for(var t=1;t<arguments.length;t++){var n=null!=arguments[t]?arguments[t]:{};t%2?ms(Object(n),!0).forEach(function(t){f()(e,t,n[t])}):Object.getOwnPropertyDescriptors?Object.defineProperties(e,Object.getOwnPropertyDescriptors(n)):ms(Object(n)).forEach(function(t){Object.defineProperty(e,t,Object.getOwnPropertyDescriptor(n,t))})}return e}var Os={READY_EVENT:"ready",PLAY_EVENT:"play",PAUSE_EVENT:"pause",TIME_EVENT:"time",SEEK_EVENT:"seek",COMPLETE_EVENT:"complete",VOLUME_EVENT:"volume",MUTE_EVENT:"mute"},_s=Object.values(Os),Ss={FULLSCREEN_EVENT:"fullscreen",ANCHOR_STATUS_EVENT:"anchorStatusChanged",ANCHOR_CLOSED_EVENT:"anchorClosed"},Es={AD_PLAY_EVENT:"adPlay",AD_PAUSE_EVENT:"adPause",AD_RESUME_EVENT:"adResume",AD_COMPLETE_EVENT:"adComplete",AD_TIME_EVENT:"adTime",AD_MUTE_EVENT:"adMute",AD_SKIPPED_EVENT:"adSkipped",AD_ERROR_EVENT:"adError",AD_BLOCK_EVENT:"adBlock",AD_REQUEST_EVENT:"adRequest",AD_OPPORTUNITY_EVENT:"adOpportunity",AD_IMPRESSION_EVENT:"adImpression"},ws=Object.values(Es),Ps=Object.values(bs(bs(bs({},Os),Es),Ss)),Ts=function(){function e(t,n){var r=this;Ai()(this,e),f()(this,"eventsCallbacksHandler",void 0),f()(this,"store",void 0),f()(this,"videoStatusSubscriber",void 0),f()(this,"videoMuteSubscriber",void 0),f()(this,"videoVolumeSubscriber",void 0),f()(this,"videoTimeFragmentSubscriber",void 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t=hn.videoTagStatus(e);switch("seeking"===this.previousVideoTagStatus&&this.reportSeekEnd(e),t){case"paused":this.eventsCallbacksHandler.onEvent(Os.PAUSE_EVENT);break;case"seeking":this.startSeekTime=hn.currentVideoTimeFragment(e);break;case"complete":this.eventsCallbacksHandler.onEvent(Os.COMPLETE_EVENT);break;case"playing":this.eventsCallbacksHandler.onEvent(Os.PLAY_EVENT)}this.previousVideoTagStatus=t}}],[{key:"getVideoStatusDependencies",value:function(e){return[hn.videoTagStatus(e)]}}]),e}();f()(Ts,"getVideoMuteDependencies",function(e){return[gn.muted(e)]}),f()(Ts,"getVolumeDependencies",function(e){return[gn.volume(e)]}),f()(Ts,"getVideoTimeDependencies",function(e){return[hn.currentVideoTimeFragment(e)]}),f()(Ts,"getVideoListDependencies",function(e){return[Cn.videoList(e)]}),f()(Ts,"isContentEvent",function(e){return _s.some(function(t){return t===e})});var As=function e(t,n){var r=this;Ai()(this,e),f()(this,"eventsCallbacksHandler",void 0),f()(this,"store",void 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{"is_conflicting_with_other_jw_players":false,"programmatic_play_with_sound_on_desktop":false,"referrer_id":"af93e181-b289-0560-a2bf-808e93bb05bc","width":"100","comscore_publisher_id":"18120612","monetization":{"ad_type":"static_tag","continue_content_play_while_waiting_for_ad":false,"strategy":"on_player_load","ad_request_timeout":"10000","midrolls":{"on":[0]},"vpaid_mode":"ENABLED","ad_tag":"https://pubads.g.doubleclick.net/gampad/ads?sz=400x300|640x480|480x270|640x360&iu=/175840252/MMPlus/smithsonianmag/Video&impl=s&gdfp_req=1&env=vp&output=vast&unviewed_position_start=1&url=##REFERRER_URL_UNESC##&description_url=##DESCRIPTION_URL_UNESC##&correlator=##CACHEBUSTER##&cust_params=mm_midroll%3D##MIDROLL_ORDER##%26video_ID%3D##VIDEO_ID##"},"sponsorship":false,"player_identifier":"mplayer","recommendation_id":null,"brand_color":"#FF9900","powered_by_strip":true,"platform":"buffy","type":"video","config_name":"MM+ | Smithsonianmag | Podding","player_id":"3v9g2u2f","playlist_id":"fSkmeWKF","playback_method":"autoplay","anchor_viewability_method":"none","player_version":"v4","playlist_type":"semantic","semantic_options":{"scan_images_on_page":true,"scanned_element":"","tags":"geogrophy,nature,animals,habitat,outdoors,science,history","minimum_date_factor":30,"scanned_element_type":"tag","scoped_keywords":"mentalfloss","promoted_videos":[]},"script_destination":"mm","publisher_contribution":"floor8","general_script_description":"","brand_logo":"","brand_logo_click_url":"","next_video":"none","uniq_key":"af93e181-b289-0560-a2bf-808e93bb05bc","content_id":"fSkmeWKF","content_type":"semantic"})); Finland has vastly improved in reading, math and science literacy over the past decade in large part because its teachers are trusted to do whatever it takes to turn young lives around. This 13-year-old, Besart Kabashi, received something akin to royal tutoring.

      Kari Louhiuori, a principal at a Finnish school made a mostly unheaard of and uncanny decision to hold back an immigrant student from 6th grader named Besart because he hadnʻt felt that this young man was falling behind due to laziness but to a lack of comprehension. After a year of "royal tutoring," by allowing the boy to read at his own pace, it worked!

    1. .PDB 檔中有什麼資料?

      可以用 "c:\Program Files (x86)\Windows Kits\10\Debuggers\x64\dbh.exe" dump .pdb 的內容 e.g. dbh.exe" -v proeforth.pdb x proeforth!Pro dbh.exe" -v proeforth.pdb x proeforth!KVM dbh.exe" -v proeforth.pdb x proeforth!user*

    1. Their establishment gave the decisive impetus to the emergence of an applied psychology, congenial to the pragmatic temper of our pursuits.

      Freud, Jung, and the work of Simon-Binet had the necessary impact to send ripples of approval for applied psychology through the U.S. psychological societies webs. It seems to have opened doors and windows that had previously been shuttered. Huge momentum would follow, no doubt.

  4. Sep 2020
    1. Reviewer #3

      The authors provide a clear and effective response to the demand for robust real-time pose estimation software with closed-loop feedback capabilities. In addition, we appreciate the effort that the authors have put into making the software user-friendly and extensible. The paper is very well written and contains many tools for those in the field to effectively use.

      A small weakness is the authors have demonstrated the LED flash latency but do not show an application such as optogenetic stimulation or behavioural manipulation using the system. Also, most of their benchmark numbers are based on videos and not camera streams, this does not fully address potential hardware issues. I believe the heavy dependence on video data and not actual ground truth live video feed is something that should be checked to present accurate numbers.

      Their Kalman filter approach seems useful but the deviations in pose estimation prediction from the normal pose estimation are sometimes 30 px or more. People may make trade-offs between latency and accuracy when using this software. Another important factor for real-time tracking is the accuracy of the pose estimation, it determines whether the system is really useful in true application.

      It would be nice to see a bit more validation of the software in a realistic live stream context. The quality of their code is quite high.

      1) The authors emphasize that their software enables "low-latency real-time pose estimation (within 15 ms, at >100 FPS)". Upon inspection of table 2, it appears that this range of latency and speed combinations is primarily achieved using 176x137 px images on Windows/Linux GPU based hardware, with corresponding FPS dropping to well below 100 for larger images in the DLCLive benchmarking tool on all platforms except for Windows. As the range in framerate/latency combinations appears to vary quite a bit between setups and frame sizes, we would suggest including a more realistic range for the latency and framerate in the abstract or at least mention the heavily down-sampled video used.

      2) In table 2, the mean and SD latency appear to be stable across modes, frame sizes, and GPU setups. However, there appears to be a notable spike in the latency range (14 {plus minus} 73) for the image acquisition to LED time on Windows computers that stands out from other latency figures. This latency range is concerning for the consistency of real-time feedback applications on a platform and at a frame size that is likely to be commonly used. Would the authors be able to explain a possible reason for this large SD?

      3) The DLG values appear to have been benchmarked using an existing video as opposed to a live camera feed. It is conceivable that a live camera feed would experience different kinds of hardware-based bottlenecks that are not present when streaming in a video (e.g., USB2 vs. USB3 vs. ethernet vs. wireless). Although this point is partially addressed with the demonstration of real-time feedback based on posture later in the manuscript, a replication of the DLG benchmark with a live stream from a camera at 100 FPS would be helpful to demonstrate frame rates and latency given the hardware bottlenecks introduced by cameras.

      4) In Figure 3, the measurement of the latency from frame to led is not very clear. The DLC will always give pose estimation even when the tongue is not appeared in the image so the LED will always be turning on very quickly after obtaining the pose from the image.

      5) In "Real-time feedback based on posture", the Kalman filter approach to reduce latency through forward prediction is innovative and likely of use for rapid characterization of general behaviours. In Figure 8C, the deviation of pose predictions from non-forward predicted poses appears to follow the general trend of the trajectory but appears to deviate by as many as 50 pixels from the non-forward predicted poses. While this tolerance may be acceptable for general pose estimation, many closed-loop pose estimation implementations may focus on rapid and accurate feedback based on very small movements (e.g. small muscular movements). For example, movements differing in magnitude by a few pixels may distinguish spontaneous twitches from conditioned behaviours. Considering that the demonstrated setup achieves a mean image to LED latency of 82 ms without the Kalman filter, it appears that many users would have to make a large trade-off between accuracy and latency in order to use the system with a conventional webcam and reasonably priced setup. Although the methods discussed are state-of-the-art and impressive considering the hardware used, it may be helpful to include a discussion of how the Kalman filter approach may be improved in the future to improve pose estimation accuracy while maintaining low latency.

      6) The software is compared favourably to existing real-time tracking software in terms of latency (refs 12-14). The efficacy of the existing realtime pose estimation software has been validated on animal movements using closed-loop conditioning paradigms. If feasible, a demonstration of the software reinforcing an animal based on real-time pose estimation (e.g. a similar paradigm to that used in the DLG benchmark video) would provide useful context as to whether the pose estimation strategies discussed are effective in closed-loop experiments. In particular, this would be important to evaluate given the novel Kalman filter approach - which influences the accuracy of pose estimation. We list this closed loop experiment as optional given the pandemic conditions we face. In contrast to the live animal reinforcement experiment, we do feel that real world streaming video to output trigger latencies are required (pt #3).

    1. View

      I like the idea of science and religion being viewed as different windows on the same universe, because I generally have not considered science and religion to be compatible but if they are thought of as two completely separate ideas rather than two conflicting ideas trying to explain the same thing, then I think they can more easily coexist

    Annotators

    1. Windows PC with Internet Explorer

      This is why older websites had those annoying badges reading "Best Viewed with Internet Explorer/Netscape Navigator/Mozilla Firefox/etc."

    1. SciScore for 10.1101/2020.09.24.20201319: (What is this?)

      Please note, not all rigor criteria are appropriate for all manuscripts.

      Table 1: Rigor

      <table><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Institutional Review Board Statement</td><td style="min-width:100px;border-bottom:1px solid lightgray">Section 1 of the survey tool used contained study information and consent, and a question to confirm the provision of care in RMNH since March 2020.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Randomization</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Blinding</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Power Analysis</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Sex as a biological variable</td><td style="min-width:100px;border-bottom:1px solid lightgray">Descriptive statistics Most respondents were female (72% or 184), aged 41-50 years (38% or 96), medical officers/registrars/house officers (40% or 101), from state Ministry of Health secondary facilities (52% or 133) and 63.7% (163) had a management role.</td></tr></table>

      Table 2: Resources

      <table><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Software and Algorithms</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">IBM SPSS Statistics for Windows, Version 25.0.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>SPSS</div> <div>suggested: (SPSS, RRID:SCR_002865)</div> </div> </td></tr></table>

      Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


      Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

      Strengths and limitations There are key strengths of note in our study, this was the first to go beyond just reporting levels of preparedness to understanding the determinants of health worker perception of HF preparedness and mechanisms that they use to cope during the COVID-19 pandemic. Compared to the earlier studies on preparedness to manage COVID-19 we explored the interaction between determinants of preparedness that included known risk factors of health worker stress and factors that can improve preparedness using ordinal regression analysis. Our study was conducted in a COVID19 safe way (online survey), most respondents were in management and clinical roles and were front line health workers, thus increasing the validity of the results. However, our study is not without limitations, Our sample was relatively small (256) for the size of the health workforce but was more than the minimum sample size of 240 required for ordinal regression analysis based on the recommendation of Hosmer, Lemeshow, and Sturdivant (2013) of a minimum sample for ordinal regression analysis of 10 observations per independent variable. 30 Also faith-based/private owned health facilities were under-represented (less than 10% all response) but over 85% of health facilities in Lagos are privately owned. 15 Other studies have reported a preference for privately owned health facilities for childbirth by about 50% of women irrespective of social class. 31,32 Therefore, our study may not be representa...


      Results from TrialIdentifier: No clinical trial numbers were referenced.


      Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


      Results from JetFighter: We did not find any issues relating to colormaps.


      About SciScore

      SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

    1. We are inspired by a perspective on curriculum dating back several decades and expounded upon in a chapter of the 1999 book Educating Minds and Hearts(McIntosh & Style, 1999). The general idea is that curriculum is a structure that provides “windows out into the experiences of others, as well as mirrors of the students’ own reality.” For students from under-represented groups, many mainstream curriculum activities skew toward being windows more than mirrors, focusing on experiences for which they are onlookers, rather than experiences in which they can see themselves. We want the topics for our modules to both reflect the lives of participants and expand their horizons by giving them insights into other people’s lives. In order to assure that topics we are considering are“mirrors” for participants, we have been working with middle school advisorswho weigh in on topics in terms of their relevance and interest to others like themselves.

      such an interesting approach

    1. Oh, but I have a strange and fugitive self shut out and howling like a wolf or a coyote under the ideal windows.

      This is denoting to the earlier lines, where he talks about the two sides of him, and how one side gets suppressed. I find this really interesting because of the part that says howling like a wolf or coyote, because in a way this means this side of his identity is yearning to be revealed

    1. void crowded indoor poorly ventilated environments. Spend more time outdoors. Maintain your distance (more is better but 2 metre is not a panacea). Improve ventilation: open windows/doors. Wear a mask indoors. Wash hands. (27/n) (https://vox.com/science-and-health/2020/5/22/21265180/cdc-coronavirus-surfaces-social-distancing-guidelines-covid-19-risks…)
    2. Prolonged indoor contact in a crowded and poorly ventilated environment increases the risk of transmission substantially. But decreasing occupancy and improving ventilation through opening windows/doors can lower the risk. (11/n)
    3. Prolonged indoor contact in a crowded and poorly ventilated environment increases the risk of transmission substantially. But decreasing occupancy and improving ventilation through opening windows/doors can lower the risk. (11/n)
    1. Reviewer #2:

      This manuscript concerns the application of a narrowed mass window DIA method for simultaneous detection of modified (methylated, succinylated, acetylated Arg and Lys) and unmodified peptides in the same MS run. The authors use a combination of synthetic peptide libraries and immunoaffinity enriched samples to compare the performance of several mass windows, ultimately showing improved separation of modified and unmodified (precursor) peptidoforms using a 4 Da separation window. They apply this method with a modified site localization algorithm to identify modification sites that are differentially affected by hypo- and hypermethylation potential in mouse NASH models. These studies reveal potential connections between SAM levels and methylation potential with mRNA translation and acetylation levels. Overall, this work presents a new methodology for simultaneous detection and quantitation of modified proteoforms without requiring parallel runs for enriched and unmodified protein detection. This methodology should be of interest to the proteomics community. Several of the mechanistic connections made in the NASH model are preliminary. There are several other aspects of the method presentation that should be addressed in the comments below.

      Major Concerns/Comments:

      1) The mechanistic jump from moderate alteration of methylation in three ribosomal proteins to causing decreased mRNA levels is not supported. The authors would need to add significantly more detail on where these modifications are and what quantitative changes are observed, as well as how these changes can affect the function of the protein of interest. Additionally, the claim that using the 4 Da DIA acquisition aids in understanding this mechanism should be expanded.

      2) Similarly, the connections listed in the acetylation section are very tenuous. Specific proteins and deacetylases are listed and connected, but other relevant proteins that play redundant or counteracting roles are not considered. A more holistic presentation of sirtuins and hdacs should be included as they will collectively control the acetylation status. Finally, what is the conclusion of this section? That acetylation is lowered due to a series of effects leading to sirt3 mediated deacetylation? This should be supported experimentally if these claims are to be made.

      3) Overall, the causal, rather than corrective relationships discussed on the sections focused on quantifying differential methylation/modification present in hypo/hypermethylated mouse models should be changed. For example, the authors make statements like "to determine the role that differential methylation potential plays in NASH...". The altered prevalence of sites is correlated with altered methylation potential, but these data do confirm they are playing a role in NASH. Statements like these should be adjusted.

      4) Do the authors integrate information about cleaved peptides? This co-isolation issue is primarily an issue when exactly the same peptide +/- modification is close in chromatographic space. Yet the unmodified version of many of these target peptides will be cleaved by trypsin, creating a completely different peptide. How is this accounted for in data analysis?

      5) The authors include a section on modifying the localization algorithm Thesaurus for the modifications studied here. Can the authors discuss these changes so the readers can assess whether these changes are appropriate and how they affect the altered performance?

    2. Reviewer #1:

      The manuscript by Robinson et al describes improvements to the DIA technique that are focused on enabling the quantitation of peptides bearing subtly different PTMs on lysine and arginine residues. The technique utilizes small DIA isolation windows to avoid co-isolation of precursor peptides whose m/z's are close (i.e. unmethylated vrs monomethylated or mono- vrs di-methylated, etc). The authors demonstrate that it can be utilized on unenriched samples which permits simultaneous assessment of changes to whole protein levels. Furthermore, they extend their localization algorithm (Thesaurus) to utilize these data and show POC by characterizing changes to PTMs in two mouse models of NASH.

      The study represents quite a lot of work and it shows a high level of methodological sophistication, however it is quite narrow in scope. It will be of interest to mass-spectrometrists that utilize DIA, but not to a general audience.

      Specific concerns:

      1) The paper barely acknowledges the fact that peptides modified on lysine and arginine typically don't cleave efficiently with trypsin thereby resulting in missed cleavages. Thus most of the time it's quite simple to distinguish modified from unmodified without the need for narrow isolation windows.

      2) DIA can be quite useful, but this reviewer cannot help but think that PRM might be more well-suited to detailed studies of peptidoforms with subtly different PTMs. If PRM is utilized, isolation windows can be as narrow as 1Da so the techniques employed in this manuscript are unnecessary.

    1. In 1951, thousands of whites in Cicero, 20 minutes or so west of downtown Chicago, attacked an apartment building that housed a single black family, throwing bricks and firebombs through the windows and setting the apartment on fire. A Cook County grand jury declined to charge the rioters—and instead indicted the family’s NAACP attorney, the apartment’s white owner, and the owner’s attorney and rental agent, charging them with conspiring to lower property values. Two years after that, whites picketed and planted explosives in South Deering, about 30 minutes from downtown Chicago, to force blacks out.

      White folks used physical force to remove Black people from their neighboods. They went as far as burning houses down which I think dull or foolish

    1. may have adopted such symbols as a deliberate strategy

      This passage from Chapter 8 reveals the links that formed between the Hindu and Islamic cultures around the 1400s in India. As Muslim populations moved into Southeast Asia, their culture and religion began to adapt to the region to gain converts. Ofter when different cultures or religions interact, they incorporate elements from the new, called syncretism. Adapting to the local culture also improved the ability of the ruling Muslims to manage the locals. The willingness of Islam to adapt, along with the inherent flexibility of the Hindu belief system, allowed monotheism and polytheism to mix fluidly. Although decidedly different, they share similar beliefs when it comes to nature. In an journal by J.J Burman, he identifies a trend in Islamic-Hindu syncretism: “Right from ancient days, syncretism was linked to shrines dedicated to objects of nature”. Both religions saw plant life as an extension of the divine. Hindus believe that much of the natural world was linked to deities who visited these sites, and were therefore sacred. This is similar to the Muslim associations with gardens as an oasis, linked to spirituality. Both religions also share the idea of nature as a provider for people from God/gods (Burman). Furthermore, the mixing of culture is seen in religious architecture and art in the area. Mulsim culture brought rigid and impressive architectural creations that became more open to the natural world, incorporating balconies, windows, and larger visible and accessible gardens around their mosques.

      J. J. Roy Burman. (1996). Hindu-Muslim Syncretism in India. Economic and Political Weekly, 31(20), 1211-1215. Retrieved September 17, 2020, from http://www.jstor.org/stable/4404148

    2. This passage from Chapter 8 reveals the links that formed between the Hindu and Islamic cultures around the 1400s in India. As Muslim populations moved into Southeast Asia, their culture and religion began to adapt to the region to gain converts. Ofter when different cultures or religions interact, they incorporate elements from the new, called syncretism. Adapting to the local culture also improved the ability of the ruling Muslims to manage the locals. The willingness of Islam to adapt, along with the inherent flexibility of the Hindu belief system, allowed monotheism and polytheism to mix fluidly. Although decidedly different, they share similar beliefs when it comes to nature. In an journal by J.J Burman, he identifies a trend in Islamic-Hindu syncretism: “Right from ancient days, syncretism was linked to shrines dedicated to objects of nature”. Both religions saw plant life as an extension of the divine. Hindus believe that much of the natural world was linked to deities who visited these sites, and were therefore sacred. This is similar to the Muslim associations with gardens as an oasis, linked to spirituality. Both religions also share the idea of nature as a provider for people from God/gods (Burman). Furthermore, the mixing of culture is seen in religious architecture and art in the area. Mulsim culture brought rigid and impressive architectural creations that became more open to the natural world, incorporating balconies, windows, and larger visible and accessible gardens around their mosques.

      J. J. Roy Burman. (1996). Hindu-Muslim Syncretism in India. Economic and Political Weekly, 31(20), 1211-1215. Retrieved September 17, 2020, from http://www.jstor.org/stable/4404148

    1. One winter there was a freezing rain. How beautiful! people said when things outside started toshine with ice. But the freezing rain kept coming. Tree branches glistened like glass. Then brokelike glass. Ice thickened on the windows until everything outside blurred.

      Gives reader an idea of the setting/imagery

    2. One winter there was a freezing rain. How beautiful! people said when things outside started toshine with ice. But the freezing rain kept coming. Tree branches glistened like glass. Then brokelike glass. Ice thickened on the windows until everything outside blurred. Farmers moved theirlivestock into the barns, and most animals were safe. But not the pheasants. Their eyes froze shut.

      Focused on setting and environment that the people and animals lived in.

    1. broken-windows or quality-of-life policing

      Broken windows policing theory is the idea that any visible signs of physical or social disorder in an environment encourages others to engage in crime. Therefore police focus on reducing crime so crime control is their top priority so they focus in areas where low-income families live. This can lead to excessive arrests in area where minorities tend to be living around creating unethical arrests due to race.

    1. The migraine has acted as a circuit breaker, and the fuses have emerged intact. There is a pleasant convalescent euphoria. I open the windows and feel the air, eat gratefully, sleep well. I notice the particular nature of a flower in a glass on the stair landing. I count my blessings.

      In the end she seems somewhat thankful for the migraine. She was angry in the beginning, but she has accepted it for what it is.

    1. my parents provided for us very well. We had two cars, and my father owned his house. We had the Valley-Hi home layout that had two baths and four bedrooms, instead of the smaller one-bath, three-bedroom model. We had central air instead of window units, and we never used fans during the summertime or even had our windows open. In the winter, we could turn on the heat. I would visit other kids’ houses and find that they bundled themselves in sweatshirts, and if someone showered, they had to open the door to let the hot steam into the house. We had it very well, and we knew we had it very well. It wasn’t until I went to college that I realized that I did not have it so well. And it wasn’t until a Thai friend was showing me Thai music videos that he had just picked up during his last visit to Thailand that I realized that there were different varieties of Thai

      with everything she has in america, she lost the time to catch up on her background

    1. strides=(1, 1)

      Set to a higher value if you don't want the filters to apply to overlapping windows of the input data.

      Otherwise, set to a value smaller than kernel_size so that you get an overlap. Typically, we set to (1,1) which means the windows are moved forward and downward 1 step each.

    1. “I’d wet a washcloth and put it over my face. I couldn’t open the windows. I just got sick and tired of it,” says Reed

      More descriptive language to help the readers visualize Reed's situation. Using Pathos and to appeal to emotion to make the audience feel her frustration.

    Annotators

    1. After two less-than-stellar projects, Taylor is back in top shape. She has truly crafted her own folklore: stories that simultaneously serve as parallels to her own life and windows into her deepest fears and desires. We’ll be unpacking folklore for years to come

      she is back at the top of her game

    1. Natural ventilation is the ventilation of a building with outside air without using fans or other mechanical systems. It can be via operable windows, louvers, or trickle vents when spaces are small and the architecture permits.

      Basically, this is stating that the most simple and cheap way to ventilate a building or structure is with natural ventilation. This can be anything as easy as opening a window for draft, or even a small louver.

    1. Mine eye hath play'd the painter and hath stell'd,Thy beauty's form in table of my heart;My body is the frame wherein 'tis held,And perspective it is best painter's art.For through the painter must you see his skill,To find where your true image pictur'd lies,Which in my bosom's shop is hanging still,That hath his windows glazed with thine eyes.Now see what good turns eyes for eyes have done:Mine eyes have drawn thy shape, and thine for meAre windows to my breast, where-through the sunDelights to peep, to gaze therein on thee;     Yet eyes this cunning want to grace their art,     They draw but what they see, know not the heart.

      The first four lines seem to discuss obviously her beauty and how he is seeing it. This was his way of saying beauty is in the eye of the beholder and I hold your beauty within myself in my love for you. He verifies this thought by using the next for lines to explain that you must see the beauty of art through the painters eyes, that the creator of these thoughts or "paintings" will always be the one to love them the most. In the ending of this sonnet, he goes on to explain that is possible and OK to see these things through a different frame of reference but it will never be as beautiful as it was intended to be.

    1. The transparent theory of language assumes the opposite, that words are more like clear windows opening to a meaning that can be separated from language.

      I agree with this theory. Words individually mean lots of things. It is important to look into their definitions and understand them to understand what the text is trying to portray. A phrase could mean so much more if you try to look past the initial phrase.

    Annotators

    1. This manuscript is in revision at eLife

      The decision letter after peer review, sent to the authors on June 12, 2020, follows.

      Summary

      All three reviewers agree that the research question under study, the requirement of the cross-talk between two important developmental signaling pathways - retinoic acid and the NO - for amphioxus pharynx development, is in principle interesting and could be suitable for publication in eLife.

      However, at present there are major open concerns especially on the lack of statistical analyses, quality of data presentation and inconsistencies with previously published work, that need to be addressed. Although it is the current policy of eLife to avoid additional experiments in revisions as much as possible, this is unfortunately likely impossible to fulfil with the current manuscript in order to bring it to a level that matches the standards of eLife. However, we think that in many cases an improvement of analyses and data presentation will likely already significantly improve the manuscript.

      1) The presented study is a follow-up on a previous paper by the same lab (Annona et al 2017 ; DOI:10.1038/s41598-017-08157-w). When comparing the work of this previous study with the current manuscript two major discrepancies are apparent:

      In Annona et al the two drugs were used to inhibit NOS production: L-NAME and TRIM, while only one inhibitor was used in the present study. Furthermore, there appear to be discrepancies concerning the developmental time windows during which chemical disruption of NO signaling is effective described in the two publications. This needs to be clarified.

      The timing of NosA,B,C expression, the suggested regulation of NosA and B by retinoic acid (RA) and the detected presumptive RARE regulatory elements in the genome don't match. More specifically, NosA,B,C expression at 24 hours (or around this time point) was investigated by Annona et al, 2017. Based on these data, NosA is not expressed during development, whereas NosB and NosC are expressed. In the submitted manuscript, the authors show that NosA and NosB are upregulated upon RA treatment, whereas NosC shows no changes in expression. They therefore suggest that RA regulates NosA and NosB transcription. Since only NosB is expressed during the relevant timepoints at early development, the transcription of this gene could be under the regulation of RA. However, when the authors look into the retinoic acid response elements (RARE) in the genomic region of NosB, they only find a DR3, which is not the typical RARE. They find DR1 and DR5 (apart from DR3's), which are more typical RARE's, in the genomic region of NosA, but as mentioned this gene is not expressed during development. This makes the hypothesis of a direct regulation of NosA and NosB by RA during normal development unconvincing. Can the author dissolve these apparent discrepancies?

      2) The authors study the open chomatin structure at 8, 15, 36 and 60 hours, thus time points, which do not overlap with the drug treatment period (24-30 hours). They need to analyze the genome architecture at this time period.

      3) The previous work by Annona et al 2017 et al shows that a major peak at NO levels occurs later than the chosen treatment window. How do NO levels during the time window of the experiment compare with other studies, i.e. is there evidence these are relevant levels? This is particularly noteworthy, as there is no control experiment showing that TRIM incubation affects NO levels or NO signaling during the incubation period (e.g. DAF-FM-DA staining or by NO quantification). It is therefore not possible to estimate the specificity of the resulting phenotypes.

      We thus request from the authors to provide ISH patterns of all the Nos genes, as well as NO localisation from at least 2 timepoints (e.g. start and end of window) of the TRIM application window.

      4) One overarching critique is that the general description of the figures and hence also the phenotypes are of poor quality. An improvement of this point will already majorly improve the entire manuscript.

      Fig.1A: Indicate developmental stages (N2, N4, T1, T2, T3, L0) together with the hours-post-fertilization (hpf) to facilitate the understanding of the treatment period with respect to the development of amphioxus.

      Fig.1B: Outline pharyngeal region e.g. with thin, dashed white lines in longitudinal and cross-sections and indicate relevant anatomical structures (club-shaped gland, endostyle, gill slits) e.g. with an arrow. Is the endostyle positioned more ventrally in TRIM treated larva?

      Figure 1C: why are Cyp26.3, Rdh11/12.18 and Crabp shown in triplicates?

      Fig.1B: The 'digital sectioning' method using confocal imaging and reconstruction of nuclear stainings is not suited to characterize the phenotype. Due to the loss of signal in deeper regions, morphological structures (e.g. differences in pharyngeal and gill slit morphology, endostyl, club-shaped glands) are impossible to recognize.

      Fig.3B: the heads of these amphioxus should be annotated to indicate key structures for non-amphioxus specialists. Ideally the images should be higher magnification and resolution as well, as the morphology is currently not very clear.

      Fig.3A and B: Furthermore, the morphological differences between 'altered', 'partially recovered' and 'recovered' is unclear. Fig.3B does not help understanding changes as the pictures are too small to recognize any morphological details without staining, and no structures are indicated. It is also unclear how animals scored as 'altered', 'partially recovered' and 'recovered' differ in their morphological structures. And does 'recovered' mean that these embryos show an initial phenotype that then 'recovers' during development, or do they show a completely normal development?

      5) Missing statistics/statistical information: Lines 85-89 (Fig.1): Where is the evidence that there is reduction in pharynx length? Where is the evidence for a smaller first gill slit? Measurements with a decent sample size and a basic statistical test must be provided.

      The description of ISH pictures in Fig.2A lacks any quantification and thus any information on the penetrance of the respective phenotypes are (as in Fig 3C). The lack of any 'negative control genes' (the large set of genes that, based on the RNASeq dataset, should not be affected) make it difficult to judge how specific changes in AP axis and RA pathway genes are.

      How did the authors obtain the qRT-PCR calculations? They need to clarify how they obtained the Fold changes shown in the histograms .e.g. by showing the maths behind the result when marking the cells in the excel sheet. The raw data for rpl32 is missing for Crabp in Figure 2B. The qPCR results in Fig.2B-E lack significance tests.

      6) The RNA-Seq study needs improvements: The PCA (Fig.S1C) shows no concordance among control samples or treated samples. Also, the histogram shows a clustering of replicates, and NOT of 'treated' and 'control' samples. This casts doubts on the quality and validity of the RNASeq dataset. These doubts are not removed by the current validation experiments, as these experiments tested only significantly upregulated genes by RNA-Seq, while downregulated and non-significant genes as 'controls' are missing. These additional controls are necessary to assess the validity of the RNA-Seq data.

      7) More information about the details of the ATACseq and ChIPseq data used, as well as the general RA responsive elements prediction is required.

      For example, in what amphioxus samples (and treatments if any) are these ATACseq and ChIPseq signals seen? There is some detail provided in the Methods section, but something is odd here and perhaps needs some further explanation. Since the two relevant Nos genes are supposedly not active during development then why do they have ATACseq and ChIPseq signals from embryo and larval samples? Why should these two Nos genes have apparently active regulatory elements focused on RAREs when the genes are not normally expressed under the control of RA, but only become active when exogenous RA is applied? We may well have missed something in the logic here, but this merely shows that the current level of explanation is insufficient.

      The analysis of RA responsive elements lacks statistical analysis and depth. It is left unclear how many RAREs would be expected by chance on a 52kb resp. 25kb locus. In addition, the authors include all ATAC-Seq peaks from stages ranging between 8h and 60hpf, while the window of RA responsiveness has been tightly restricted to the 24h-30hpf window. Also, as NosC expression levels stay constant upon RA incubation, it would be crucial to know if the NosC locus lacks any open RARE sites (as would be expected).

      The authors use NHR-SCAN tool to predict putative direct repeats binding sites in the genomic sequence of NosA and NosB. Which consensus sequence does the program follow? It appears that it does not follow the consensus sequence for typical RARE ((A/G)G(G/T)TCA), since the sequence for DR1 deviate from this sequence? DR1, DR2 and DR5 are the commonly described binding RARE's for the RAR/RXR heterodimers. Further, DR8 has been described as retinoic acid dependent regulation of gene transcription through RAR/RXR (Moutier et al., 2012). The authors need to provide clarification which are the most commonly used RARE's of the DR's detected.

      Please also mention if RAREs fall within an intron in the genomic regions of the Nos genes, since the transcriptional regulation through RARE is often associated to introns.

      8) Information on the concentration dependency of compounds used in the rescue experiment is lacking. Please explain why the BMS009 concentration used here (10exp-6 M) is 10x higher than the highest concentration used in the original publication on amphioxus pharynx development (Escriva et al., Development 2002).

      9) A summary drawing of the regulatory loop between NO and RA would be informative, also indicating the known target genes (from this study).

    1. we all know that mac operating systems are only operatable on Mac machines. And non-mac devices do not support macOS. Is this true? Well, to some extend, it is true. Officially you cannot install macOS on Windows PC. however, we must recognize that we are living in the 21st century. And technology has become advance to the level that it can make things possible. and similarly, the technology itself has brought a method to install mac operating systems on non-mac devices such as Windows, Kali Linux, or Ubuntu.

      Now, you can install mac operating systems on these non-mac operating systems.

      Secondly, you might think it as a malicious or harmful way to do it. What if I say there is a 100%ligit way to do it.

      Yes, there is some new software, that are used for this purpose. Those are called Virtual machine software. Software like Virtualbox or VMware workstations are such software.

      These two software are globally recognized software for desktop virtualization. This software was primarily developed to run multiple Operating systems on only one device.

      These two software are globally recognized software for desktop virtualization without any fraud and spam.

      Moreover, for your information, I would like to say that VirtualBox is the software by Oracle cooperation which is available free and open-source software for desktop virtualization.

      While VMware workstation is a paid tool by the VMware corporation for the same purpose. So, if you want to install macOS on Windows PC. Then these two software are the best options to do it. So, for this purpose, you can get help from the following article.

      https://techvatan.com/install-macos-mojave-on-virtualbox-on-windows/

      Moreover, you can also read some more interesting topics from below.

      https://techvatan.com/fix-macos-mojave-screen-resolution-on-vmware/

    1. A year or so earlier, Joe had shyly shuffled up to me with a question. His sartorial clock had stopped around the time his daughters left home. He wore bolos and flannel shirts and polyester pants. “So,” he’d said timidly, knitting his brows. “Have you decided what kind of business you want to go into?”I was his first grandchild. I hadn’t said then what I knew already, which was that I wouldn’t end up going into any kind of business, that I couldn’t find the appeal in the life he’d chased. That my goal was to get far from this. In Redwood City, in the summer, the sycamores dry and the grass bakes to a sweet hay smell, and the glaring sun and the tidy corners of the lawns can give you headaches through car windows in midafternoon. My grandfather had spent years inside a nightmare in the hope of bridging the great distance to this heaven. It mortified me to admit that I wanted something else.American opportunity is notoriously a path of unequal resistance. Test scores track with parental income; Zip Codes predict life expectancies. What these data do not capture is the fortuity and betrayal even in the smooth progress we seek. We say, We’re doing something for our children and our children’s children. We say, We want to give our kids the things we didn’t have. But every palace is someone’s prison; every era’s victory the future’s baseline for amendment. Our children and our children’s children: they will leave our dreams behind.

      Reflection 4: highlights the parallel between the promise of pluralism for the future, as offered by post-war San Francisco, falling flat and the author's inability to work toward the goal/ dream his grandfather fought for

    1. These are hypotheticals, but Microsoft really was caught by exactly this mechanic in mobile a decade later - no-one made apps for Window Phone because it had no users, and it had no users because no-one wrote apps for it, and all the power Microsoft had in Office and Windows meant nothing. 
    2. Microsoft might have been doing all sorts of mean and sneaky things, but people used Windows and Office because of network effects, and those network effects were and are internal to each product. People used Windows because it had the software and people wrote software for Windows because it had the users, and that had very little to do with Office.

      Dit is een kenmerkend probleem met veel software en diensten. Het netwerkeffect zorgt voor de lock-in.

    1. In addition to the widespread destruction, a fire from a leak at a chemical plant sent a massive plume of smoke stretching for miles in the area, prompting authorities to warn residents to close their doors and windows. 

      Sentence is supported by a video, readers make visual connection.

    1. When we look outside our windows now, the city resembles a massive toy set. With its citizens gone, the eeriness intensifies.

      It's ironic how the description of this setting is like the ones included in dystopian novels, but instead describes our current situation. It's as if we're getting to experience things that seem like would only happen in dystopian novels.

    1. and, if necessary, the windows—trees fifty, a hundred years oldout there,heavy clouds on the wayand the lawn steaming like a horsein the early morning.

      i can imagine this mans house: some small wood cabin in the woods with a little pond next to it. thats what scenery first comes to mind whenever i hear the poem

    1. Scroll to the very end and look for the four items that begin with Hyper-V. If you see a Yes next to each one, you're ready to enable Hyper-V.

      Hyper-V enabled

    1. City residents were advised to avoid crowds, and instructed to pay particular attention to personal hygiene. In some cities, dance halls were closed. Some streetcar conductors were ordered to keep the windows of their cars open in all but rainy weather. Some municipalities moved court cases outside. Many physicians and nurses were instructed to wear gauze masks when with flu patients.

      We are going through something with some resemblance, but when we were told to take these precautions a lot of people thought it was unreasonable even though we have done this before.

  5. Aug 2020
    1. Desinstalar antivírus.

      Não acredito que isso seja o problema, mas se você tiver algum outro antivírus instalado que não o Windows Defender, desative a proteção (não precisa desinstalar)

    1. One winter there was a freezing rain. How beautiful! people said when things outside started toshine with ice. But the freezing rain kept coming. Tree branches glistened like glass. Then brokelike glass. Ice thickened on the windows until everything outside blurred. Farmers moved theirlivestock into the barns, and most animals were safe. But not the pheasants. Their eyes froze shut.

      Focused on setting.

    1. So thou through windows of thine age shalt see,Despite of wrinkles this thy golden time.

      As you age you become more grateful towards life. This is when you are ready to bring life into the world.

    2. If I could write the beauty of your eyes,And in fresh numbers number all your graces,The age to come would say 'This poet lies;

      very cheesy, it's basically the same as modern wording of "your eyes are the windows to your soul".

    1. Reviewer #2:

      In this manuscript, Kim et al. investigate the events required for irreversible commitment to division by immortalized mammalian cells in culture. They do so by tracking single, live cells by video-microscopy using an assortment of fluorescent biosensors (augmented by fixed-cell immunofluorescence), and perturbing cell-cycle progression with cyclin-dependent kinase (CDK) inhibitors, DNA-damaging agents, or mitogen withdrawal. This is a complicated problem, which has resisted a comprehensive solution since the initial attempts to define a commitment or "Restriction" point (R point) in mammalian cells over 40 years ago. This study yields some intriguing results, and generally adds significant molecular detail to previous work on this problem by the PI and former colleagues in the Meyer lab. There are serious flaws, however, both conceptual and technical. Some of them are inherent in the approach, for example, the overreliance on small-molecule inhibitors that are not as selective as one would hope, and on live-cell biosensors that are neither as sensitive nor as specific (for individual CDKs) as they would need to be to justify some of the stronger mechanistic conclusions. Then there is the central take-home message (I think), which is based on the observation that mitogen withdrawal or DNA damaging agents have different windows of sensitivity during G1, such that the former needs to be applied earlier than the latter in order to prevent cell cycle entry. This leads to re-interpretation of the R point as a moving target, occurring at different points in the cell cycle depending on which perturbations cells encounter as they take the necessary steps to commence DNA replication. This makes little biological sense to me. The R point concept seems to lose much or all of its usefulness if it is not understood as a cellular state in which the irreversible commitment to division has been made, irrespective of what might befall an individual cell that has passed it. I think a more reasonable interpretation, of a superficially (at least) similar phenomenon, was put forth by Skotheim and colleagues, who found that the threshold level of CDK1/2 activity that predicted subsequent R-point passage was higher when all mitogens were withdrawn than when a single mitogenic signaling pathway was ablated, e.g. with a MEK inhibitor (Schwarz et al., 2018, ref 22). In this take, the R point per se is not mutable, but the strength of an antimitogenic signal can determine how quickly cells can put on the brakes before reaching it. I would urge the authors to avoid this phrasing, and aim for a bit more clarity in describing an admittedly complicated set of data. Below I Iist my major, specific concerns:

      1) Probably the biggest problem for the current study emerged from a paper by Rubin and colleagues (Guiley et al., 2019, ref. 26), which showed, quite convincingly, that the "CDK4/6 inhibitors" Palbociclib, ribociclib and abemaciclib-used throughout the current study-almost certainly do not work in cells by direct inhibition of CDK4/6, but rather by binding CDK monomers and redistributing CDK inhibitor (CKI) proteins, notably p21, to CDK2. To be fair, this is a very recent paper, which, to their credit, the authors cite and try to address. But they address it only obliquely and, I'm afraid, inadequately; although they show that effects of Palbociclib et al. are partially independent of p21 (Fig. 3B,D), this doesn't rule out contributions by other CKIs such as p27 or p57, all of which could potentially be redistributing to CDK2 complexes if CDK4 complex assembly is impaired (Guiley et al. did not test this possibility and only evaluated CDK2-CKI binding in wild-type cells). Nor do they address the strong implication of Guiley et al., that loss of CDK4/6 activity is not the mechanism by which these compounds act. This is a hugely important point; the entire study (and several previous ones from the Meyer lab) depends on the ability to inhibit CDK4/6 or CDK1/2 with different inhibitors and distinguish the effects on various cellular phenotypes and biosensor signals, which is now in considerable doubt.

      2) More generally, the study relies on small-molecule inhibitors of different CDKs that are at best only modestly selective for their intended targets. The problem with using Palbociclib in this way has been discussed above, and is a recent development, but it should be noted that major "off targets" for the "CDK4/6 inhibitors" include transcriptional CDKs such as CDK9, which are also potently inhibited by "CDK1/2" inhibitors such as roscovitine (and others). One could make the case that these drugs are hitting different targets, because they have different effects on different biosensors, but the specificity of those bioesensors was established in part by using the inhibitors, so the case that their effects occur solely or primarily through their intended targets is in the end circular.

      3) The "CDK4/6 biosensor" has in fact been shown in a previous paper by the PI to detect CDK1/2 activity in addition to CDK4/6; there was residual signal after Palbociclib treatment in cells with high CDK2 activity. Setting aside the aforementioned problem of Palbociclib specificity, if I understand correctly, to "correct" for this lack of specificity, the authors subtract 35% to generate the signal they attribute to CDK4/6. This seems to assume that the relative contributions to this fluorescence by CDK4/6 and CDK1/2 will be in a fixed proportion, or am I missing something?

      4) In previous papers from the Meyer lab, Rb hyperphosphorylation was "inferred" from concurrently increased immunofluorescence signals, in fixed cells, from a panel of phosphoRb-specific antibodies (Chung et al., 2019, ref. 18). I have my problems even with inferring stoichiometry from these types of measurements, but in this manuscript the language is even stronger: IF signals are flatly described (and interpreted) as "markers" of Rb hyperphosphorylation. This too is a major issue; a prevailing model, supported by biochemical data that are by necessity ensemble measurements, holds that CDK4/6 is primarily responsible for Rb monophosphorylation, whereas hyperphosphorylation coincides with and is dependent on activation of CDK2 (Narasimha et al., 2014, ref. 28). Although for the moment the larger concern-that anything the authors have done to inactivate CDK4/6 is likely to be indirectly inhibiting CDK2-renders this more technical point somewhat moot, conclusions-or even inferences-about hyper- versus mono-phosphorylated forms of Rb should be based on actual measurements of stoichiometry.

    1. Course Format

      Among the tools we'll be using this fall is Slack. It will be our primary place of collaboration and communication. I highly suggest you download and install the app, as it is much more convenient that way.

      (3 of 3) Click the link below to join our class Slack Team. Slack will take you on a guided tour when you join - don't skip it! After the tour, go to the #introductions channel and follow the instructions in the final stage of our scavenger hunt.

      RCA Fall 2020

    1. The Earth itself was a flat disc, surrounded by mountains or sea. Above it was the firmament, a transparent but solid dome resting on the mountains, allowing men to see the blue of the waters above, with "windows" to allow the rain to enter, and containing the Sun, Moon and stars. The waters extended below the Earth, which rested on pillars sunk in the waters, and in the underworld was Sheol, the abode of the dead.[37]

      This is saying that in the beginning the world was flat with windows and surrounded by mountains to keep it all in, this is close to how people thought it worked back then when everyone thought the earth was not round but flat.

    1. Microsoft Windows 應用程式開發介面 (Windows API) 可針對處理字元和字串的每一個函式,各包含兩個版本:一個是單位元組字元的 ANSI 版本,另一個是雙位元組字元的 Unicode 版本

      可能就是 MessageBox 與 MessageBoxA 的差別 --> Yes! 往下看就看到了。。。

    1. 3) Tell your students to study different subjects in different rooms in their house and use the cues in their surroundings (furniture, windows, colors, shapes, etc) to help them access that memory later. They could use the same rooms they imagined in their memory palace: study the modals in the living room and vocabulary in the kitchen;

      The environment we are in can help set the cues for helping us remember things better.

      This is one of the reasons why it can be useful to move between classrooms in school - goto the science room, different settings, tools, etc.

      Goto the history room - different things on the walls.

      These can all act as cues to prime you for that topic, and can help build a memory palace and a place association with the things we are trying to learn.

      This can also be useful in work - different meetings in different rooms/settings, walking meetings, etc.

    1. The sunlight pressed through the windows, thieved its way in

      This is such a detailed way of describing light entering a room, which is normally a positive sign. Here, it feels as though their home should be dark—creating an eerie atmosphere and alluding to death—and the sunlight is ruining this eeriness. It's also fitting based on the fact that this long paragraph is really referring to dead people.

    1. SciScore for 10.1101/2020.08.04.20167205: (What is this?)

      Please note, not all rigor criteria are appropriate for all manuscripts.

      Table 1: Rigor

      <table><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Institutional Review Board Statement</td><td style="min-width:100px;border-bottom:1px solid lightgray">Ethics The study protocol and its modifications were approved by the ethics committee of Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires and by the Institutional Review Board at Hospital Español</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Randomization</td><td style="min-width:100px;border-bottom:1px solid lightgray">Methods Trial design and settings We conducted this two-arm, multicenter, randomized, open-label, controlled trial at two academic hospitals in Ciudad de Buenos Aires, Argentina: Hospital de Clínicas “José de San Martín” or site 1 (HCJSM, University of Buenos Aires main hospital) and Hospital Español de Buenos Aires or site 2 (HEBA, a community hospital).</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Blinding</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Power Analysis</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Sex as a biological variable</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr></table>

      Table 2: Resources

      <table><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Software and Algorithms</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Simple randomization was performed using the GraphPad QuickCalcs Web site by a statistician with no contact with patient care (MVS).</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>GraphPad</div> <div>suggested: (GraphPad Prism, RRID:SCR_002798)</div> </div> </td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Analyses were performed using GraphPad Prism version 8.4.3 (686) for Windows. Patient and Public Involvement.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>GraphPad Prism</div> <div>suggested: (GraphPad Prism, RRID:SCR_002798)</div> </div> </td></tr></table>

      Results from OddPub: Thank you for sharing your data.


      Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

      Main limitations of the study are the lack of blinding, the exclusion of ICU patients on randomization, the low number of enrolled patients given the preliminary nature of this report, and the restriction to patients with a relatively short time from symptom onset to randomization. Therefore, additional rigorous studies are warranted to determine its value as a therapeutic tool in the Covid-19 clinical spectrum. In synthesis, the present results constitute strong evidence in favor of the involvement of the RAS in the inflammatory process observed in hospitalized Covid-19 patients and that the ARB telmisartan, a well-known inexpensive safe antihypertensive drug, administered in high doses, demonstrates anti-inflammatory effects and improved morbidity in hospitalized patients infected with SARS -CoV-2, providing support for its use in this serious pandemia.


      Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


      Results from JetFighter: We did not find any issues relating to colormaps.


      About SciScore

      SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

    1. Selbst wenn sich die innere Funktionsweise darstellen ließe, wird sie für gewöhnlich in eine Blackbox verpackt und dem Zugriff und der Einsicht der Anwender*innen entzogen14.

      Dieses hat mehrere Gründe:

      1. Know-how-Schutz Programme lassen sich sehr schnell ohne wesentliche Materialkosten reproduzieren. Deswegen sind Unternehmen darauf angewiesen Ihren Quellcode zu verstecken, um Gewinne zu erwirtschaften.

      2. Der Anwendbar ist meist am Quellcode bzw. der Funktion der KI nicht interessiert, da ein tieferes Verständnis nicht zwangsläufig einen besseren Umgang mit der Anwendung ermöglicht. Außerdem ist ein nicht unerhebliches Grundwissen in der Informatik erfindlich den jeweiligen Code der Anwendung oder deren tieferliegendes Funktionsprinzip zu verstehen.

      3. Die Entwicklung von Windows hat außerdem aufgezeigt, dass die Stabilität des Programms antiproportional mit den Möglichkeiten, den der Anwender hat das Programm manuell zu verändern oder zu parametrieren. Deswegen werden einige Funktionen bei Android und Windows mit neueren Versionen abgeschafft, da ein Großteil der Anwender sie nicht fehlerfrei Anwenden kann. - Zum Leidwesen der technikaffinen Anwender-

    1. Amid the COVID-19 outbreak and related expected economic downturn, many developed and emerging market central banks around the world engaged in new long-term asset purchase programs, or so-called quantitative easing (QE) interventions. This paper conducts an event-study analysis of 24 COVID-19 QE announcements made by 21 global central banks on their local 10-year government bond yields. We find that the average developed market QE announcement had a statistically significant -0.14% 1-day impact, which is slightly smaller than past interventions during the Great Recession era. In contrast, the average impact of emerging market QE announcements was significantly larger, averaging -0.28% and -0.43% over 1-day and 3-day windows, respectively. Across developed and emerging bond markets, we estimate an overall average 1-day impact of -0.23%. We also show that all 10-year government bond yields in our sample rose sharply in mid-March 2020, but fell substantially after the period of QE announcements that we study in the paper.
    1. La condition pour retrouver une autonomie numérique est de retrouver une littératie et de prendre en main des outils comme le terminal (MacOs, Linux) ou l’invite de commande (Windows).

      ici, on touche à un problème fort. Je ne pense vraiment pas que la piste soit un repli informatique sur la ligne de code alors que l'objectif est éditorial et dans la constitution de données structurées et interrogeables. Je suis plutôt pour une identification systémique des briques qui agissent et sur lesquelles on en train d'agir. Je pense aussi que l'interface donner une illusion de compétences d'un côté, et de l'autre éloigne et éloignera 95 % des collègues qui ont autre chose à faire que d'ouvrir une ligne de commande..

    1. Limited data are available about transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), among youths. During June 17–20, an overnight camp in Georgia (camp A) held orientation for 138 trainees and 120 staff members; staff members remained for the first camp ses-sion, scheduled during June 21–27, and were joined by 363 campers and three senior staff members on June 21. Camp A adhered to the measures in Georgia’s Executive Order* that allowed overnight camps to operate beginning on May 31, including requiring all trainees, staff members, and campers to provide documentation of a negative viral SARS-CoV-2 test ≤12 days before arriving. Camp A adopted most† components of CDC’s Suggestions for Youth and Summer Camps§ to minimize the risk for SARS-CoV-2 introduction and transmis-sion. Measures not implemented were cloth masks for campers and opening windows and doors for increased ventilation in buildings. Cloth masks were required for staff members. Camp attendees were cohorted by cabin and engaged in a variety of indoor and outdoor activities, including daily vigorous singing and cheering. On June 23, a teenage staff member left camp A after developing chills the previous evening. The staff member was tested and reported a positive test result for SARS-CoV-2 the following day (June 24).
  6. icla2020.jonreeve.com icla2020.jonreeve.com
    1. The other houses of the street, conscious of decent lives within them, gazed at one another with brown imperturbable faces.

      This sentence is similar to the mention of a gaze in "the Sisters" where the narrator gazes at Father Flynn's window and then the narrator is subject to his uncle's gaze. It seems that Joyce focuses on windows and seeing.

    1. he was stunned by a strange shiver at the sight of the first-floor windows, the majority of which were always shut and whose proximity was much too close.

      When he was on the seventh floor, he was intrigued by the first floor and was trying to get a look at the patients. Now, he is feeling anxious at how close he has gotten to their floor and worries about the severity of his illness.

    1. If he wants to work he slips out of it in a moment and can put it on again as quickly.

      It seems to me that they were being forced to adopt to the American culture "way of living". They not only expected the Chinese to leave behind their roots and become accustomed to new ways but also infiltrated their businesses by breaking their windows and blaming them of theft, they were willing to fight them if they did not get what they asked for leaving the Chinese completely powerless.

  7. Jul 2020
    1. Reviewer #1:

      This is an interesting but complex study that examines the role of a few genes in a previously mapped interval in being the "switch" gene that regulates the presence or absence of a yellow band in the wings of Heliconius butterflies. The study first examines whether there is a correlation between expression level of several (47) genes in the mapped interval in developing wings (or parts of wings) in two separate species of Heliconius each having a race with the yellow band and a race without the yellow band. This part of the study highlights three genes (among others) that show some pattern of differential regulation but shows that there is no simple correlation between the expression level of these three genes in either larval or pupal wings and the presence of the yellow band. The authors then examine the function of one of the genes in the interval, cortex, in scale color development by using CRISPR. They find that cortex crispant individuals display color changes across the whole wing, not just in the region of the yellow band. In particular the black scales (Type II) become white or yellow (Type I), and the red scales (Type III) also become white or yellow (although this last transformation is not documented at the SEM level). The authors examine, once again, the expression domain of the cortex gene, this time during pupal development with an antibody, and they find that the gene is expressed across the whole wing, supporting its functional effects also across the whole wing. They observe that cortex is expressed in multiple punctate domains in the nuclei of scale building cells, which are polyploid cells, and in a single punctate domain in the nucleus of non-scale building epidermal cells, which are not polyploid. They then test whether perhaps there are more of these punctate nuclei in the region of the yellow band, but they find no such correlation.

      In the end the authors try to argue that either 1) cortex is the yellow-band switch gene they are after but that the switch is not in the form of a typical spatially expressed gene (in the shape of the yellow band) but perhaps in the form of some threshold or heterochronic mechanism (not clearly explained), or that 2) another gene in the mapped interval, not examined for function in this study, is instead the switch genes they are after, and which may (or may not) interact with cortex in the differentiation of the yellow band.

      I believe the authors are trying hard to implicate cortex in some way, as the yellow band switch locus, but the data just does not support this. Instead the authors implicate cortex in scale color identity (the title of the manuscript). However, given that cortex (alone) cannot control a specific color either, because the effect of cortex on color is different in different parts of the wing, their model for how cortex acts is too simple and does not fit their data. A combinatorial genetic code for both scale color and morphology (see below), where cortex is simply one of the players (rather than a major switch/homeotic gene) is required to explain the data in this manuscript.

      Furthermore there are several data missing from the manuscript that need to be added to support some of the conclusions drawn, and several other data that would be important to add for purposes of data replication across labs.

      1) The authors claim that cortex converts Type II (black) scales into Type I (white/yellow) scales but their SEM data and scale morphological measurements presented in the supplement don't fully support this conclusion. These transformations vary from species to species (e.g. H. melpomene and H. erato show different degrees of transformation) and only some features of the scale are actually transformed (e.g., cross rib periodicity in both species, and scale width and length and ridge periodicity in H. melpomene). The remainder of the measurements show that cortex is not sufficient to convert scale Type II into scale Type I.

      2) I suggest that the definition of the scale types presented should be made more explicit. What are scale types I, II and III really? In line 87 it is mentioned that these scale types are based on scale color and on scale morphology but what follows is just a description of the pigments found in each scale and not their morphology. Furthermore, the data presented in the manuscript suggests that color and morphology can be uncoupled with genetic perturbations of cortex, so is it even useful to stick to this scale type nomenclature going forward? Something to consider.

      3) There is a need for a new figure showing how the scale morphological measurements were actually conducted. There is no scale bar in the SEM images of yellow and black scales and this should be added. The SEM images used to represent a typical yellow WT scale and a transformed yellow scale of H. melpomene (in Figure 7) show very different densities of cross-ribs (but I am not even sure what exactly is being considered a cross-rib), yet the graph indicates that there is no difference between these scale types. This is confusing and needs clarification. Make sure you look up scale morphology nomenclature in Ghiradella 1991 (Applied Optics) to make sure you designate ribs (crossribs) and microribs appropriately. There seem to be quite a lot of differences in microrib density across Wt scales and transformed yellow scales in H. melpomene.

      4) The authors claim that cortex converts Type III (red) scales into Type I (white) but they only describe conversions of Type II (black) into Type I (yellow) scales at the SEM level and don't provide any SEM images or quantitative data for the red to yellow, red to white, and black to white scale transformation. Adding these data is important to support the conclusions of the study.

      5) I suggest the authors remove the dome-t and dome/washout gene data from the manuscript as 1) nothing about these genes is mentioned in the abstract; 2) the expression of these genes doesn't correlate with presence of the yellow band; 3) the genes are not investigated at the functional level; 4) the whole gene duplication issues surrounding these genes make the whole manuscript more difficult to read and does not, in the end, contribute to the main story that yielded results - which is the function of cortex in scale development. The function of these genes might still be worthy of investigating using CRISPR at a later date, and perhaps it would be useful to include the expression pattern data in that subsequent paper. This is merely a suggestion that I believe will make this manuscript less heavy and easier to read by focusing the reader's attention on the main points of this story.

      6) Pigmentation and scale morphology is most likely controlled at the pupal stages of wing development and by measuring RNA levels of candidate switch genes at just two time points during pupal development (36hrs and 60-70 hrs after pupation) you may not have sampled the correct time window for yellow band differentiation. Several genes are expressed only during the first 16-30 hrs of pupal development, in species that need 7 days for pupal development (see Monteiro et al. 2006 for genes such as Wg, pMad and Sal) so sampling wings (for RNA-seq and antibody stains) at 36hrs and 60-70 hours may not be an ideal sampling strategy going forward.

      7) The authors mention that because cortex causes changes in both scale color and morphology this suggests "that cortex acts during early stages of scale cell fate specification rather than during the deployment of effector genes". This conclusion needs more discussion. Matsuoka and Monteiro (2018) showed that knockout of the gene yellow, an effector gene at the end of a gene regulatory network for melanin pigment production, also led to both changes in scale color and morphology. These authors proposed instead that absence of certain pigments on the wing, such as dopa melanin, caused chitin to polymerize differently and form an extra lamina that prevent the windows from forming in the scales (just as seen in cortex mutants). The authors should consider and evaluate this alternative explanation in their discussion.

      8) Did the authors examine whether there were protein coding changes between the 47 genes in the mapped interval between the yellow and black races? Please mention whether this was done. Please also upload the sequences of the genes that were studied and provide accession numbers for these sequences.

    1. She wanted to be home, or sitting on the veranda listening to those baby owls. When she looked through the dark windows at the stars, they had long beams like wings...

      Although Leila initially experienced excitement over the entertainment her relatives regularly got to enjoy, she realizes that sometimes a simple life might be the happier one. This seems to be a common theme in many of these short stories. One character seems to think about their situation, and come to an uncomfortable realization about the way they live their life.

    2. But Leila didn’t want to dance any more. She wanted to be home, or sitting on the veranda listening to those baby owls. When she looked through the dark windows at the stars, they had long beams like wings... But presently a soft, melting, ravishing tune began, and a young man with curly hair bowed before her. She would have to dance, out of politeness, until she could find Meg. Very stiffly she walked into the middle; very haughtily she put her hand on his sleeve. But in one minute, in one turn, her feet glided, glided.

      This short story ends in pretty much the exact same way as Marriage a la Mode. The main protagonist has her world come crashing down and is very distraught, but in the very next moment forgets all about it and continues to have fun.

      While it's possible that Leila is having such a great time that she forgets about the fat man, I think it's more likely that she has decided to ignore problems in her life and would rather live in her own bubble (this is also applicable to Isabel).

    1. SciScore for 10.1101/2020.07.26.20158550: (What is this?)

      Please note, not all rigor criteria are appropriate for all manuscripts.

      Table 1: Rigor

      <table><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Institutional Review Board Statement</td><td style="min-width:100px;border-bottom:1px solid lightgray">The study protocol was approved by the Ethics Committee of Kurdistan University of Medical Sciences (ref. no. IR.MUK.REC.1399.006).</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Randomization</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Blinding</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Power Analysis</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Sex as a biological variable</td><td style="min-width:100px;border-bottom:1px solid lightgray">There were 91 females (44.8%) and 112 males (55.2%).</td></tr></table>

      Table 2: Resources

      <table><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Software and Algorithms</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Statistical analysis We used Statistical Package for the Social Sciences for Windows (SPSS version 25,0; IBM Corp, Armonk, NY, USA) to perform the statistical analyses.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>Statistical Package for the Social Sciences</div> <div>suggested: (SPSS, RRID:SCR_002865)</div> </div> <div style="margin-bottom:8px"> <div>SPSS</div> <div>suggested: (SPSS, RRID:SCR_002865)</div> </div> </td></tr></table>

      Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


      Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

      Our study should be interpreted within the constraints of its limitations. First, although this was a multicenter study, all participants were from the Kurdistan province of Iran and subjective OD may be differentially reported than in other parts of the world. All of the patients who participated in our study also were presenting to an emergency department, which suggests that these patients were experiencing more severe symptoms in general, in contrast to other studies that have reported findings for COVID-19 patients with mild to moderate symptoms. Finally, we did not use objective assessment of OD due to limitations of practicality in the setting of emergency department treatment. As reported by Moein et al, who also studied Iranian COVID-19 patients, the subjectively reported prevalence of OD may be significantly lower than OD determined by objective testing.20 Conclusion Amongst patients presenting to emergency departments for COVID-19, patient-reported OD was more prevalent in those needing hospitalization for COVID-19. However, patientreported OD was a component of a generally higher prevalence of COVID-19 symptoms— including a greater prevalence of symptoms such as cough, fever, shortness of breath, headache, rhinorrhea and sore throat—as well as other high-risk comorbidities. Patient-reported OD in isolation may be a predictor of more severe COVID-19 and the need for hospitalization, but this association may be driven by other underlying risk factors for more severe disease.


      Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


      Results from JetFighter: We did not find any issues relating to colormaps.


      About SciScore

      SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.

    2. SciScore for 10.1101/2020.07.26.20158550: (What is this?)

      Please note, not all rigor criteria are appropriate for all manuscripts.

      Table 1: Rigor

      <table><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Institutional Review Board Statement</td><td style="min-width:100px;border-bottom:1px solid lightgray">The study protocol was approved by the Ethics Committee of Kurdistan University of Medical Sciences (ref. no. IR.MUK.REC.1399.006).</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Randomization</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Blinding</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Power Analysis</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Sex as a biological variable</td><td style="min-width:100px;border-bottom:1px solid lightgray">There were 91 females (44.8%) and 112 males (55.2%).</td></tr></table>

      Table 2: Resources

      <table><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Software and Algorithms</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Statistical analysis We used Statistical Package for the Social Sciences for Windows (SPSS version 25,0; IBM Corp, Armonk, NY, USA) to perform the statistical analyses.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>Statistical Package for the Social Sciences</div> <div>suggested: (SPSS, RRID:SCR_002865)</div> </div> <div style="margin-bottom:8px"> <div>SPSS</div> <div>suggested: (SPSS, RRID:SCR_002865)</div> </div> </td></tr></table>

      Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


      Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

      Our study should be interpreted within the constraints of its limitations. First, although this was a multicenter study, all participants were from the Kurdistan province of Iran and subjective OD may be differentially reported than in other parts of the world. All of the patients who participated in our study also were presenting to an emergency department, which suggests that these patients were experiencing more severe symptoms in general, in contrast to other studies that have reported findings for COVID-19 patients with mild to moderate symptoms. Finally, we did not use objective assessment of OD due to limitations of practicality in the setting of emergency department treatment. As reported by Moein et al, who also studied Iranian COVID-19 patients, the subjectively reported prevalence of OD may be significantly lower than OD determined by objective testing.20 Conclusion Amongst patients presenting to emergency departments for COVID-19, patient-reported OD was more prevalent in those needing hospitalization for COVID-19. However, patientreported OD was a component of a generally higher prevalence of COVID-19 symptoms— including a greater prevalence of symptoms such as cough, fever, shortness of breath, headache, rhinorrhea and sore throat—as well as other high-risk comorbidities. Patient-reported OD in isolation may be a predictor of more severe COVID-19 and the need for hospitalization, but this association may be driven by other underlying risk factors for more severe disease.


      Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


      Results from JetFighter: We did not find any issues relating to colormaps.


      About SciScore

      SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.

    3. SciScore for 10.1101/2020.07.26.20158550: (What is this?)

      Please note, not all rigor criteria are appropriate for all manuscripts.

      Table 1: Rigor

      <table><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Institutional Review Board Statement</td><td style="min-width:100px;border-bottom:1px solid lightgray">The study protocol was approved by the Ethics Committee of Kurdistan University of Medical Sciences (ref. no. IR.MUK.REC.1399.006).</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Randomization</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Blinding</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Power Analysis</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Sex as a biological variable</td><td style="min-width:100px;border-bottom:1px solid lightgray">There were 91 females (44.8%) and 112 males (55.2%).</td></tr></table>

      Table 2: Resources

      <table><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Software and Algorithms</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Statistical analysis We used Statistical Package for the Social Sciences for Windows (SPSS version 25,0; IBM Corp, Armonk, NY, USA) to perform the statistical analyses.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>Statistical Package for the Social Sciences</div> <div>suggested: (SPSS, SCR_002865)</div> </div>

            <div style="margin-bottom:8px">
              <div><b>SPSS</b></div>
              <div>suggested: (SPSS, <a href="https://scicrunch.org/resources/Any/search?q=SCR_002865">SCR_002865</a>)</div>
            </div>
          </td></tr></table>
      

      Data from additional tools added to each annotation on a weekly basis.

      About SciScore

      SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.

    1. SciScore for 10.1101/2020.07.28.20163295: (What is this?)

      Please note, not all rigor criteria are appropriate for all manuscripts.

      Table 1: Rigor

      <table><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Institutional Review Board Statement</td><td style="min-width:100px;border-bottom:1px solid lightgray">Before interviews, verbal informed consent was taken from all participants.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Randomization</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Blinding</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Power Analysis</td><td style="min-width:100px;border-bottom:1px solid lightgray">not detected.</td></tr><tr"><td style="min-width:100px;margin-right:1em; border-right:1px solid lightgray; border-bottom:1px solid lightgray">Sex as a biological variable</td><td style="min-width:100px;border-bottom:1px solid lightgray">Women were more at risk of anxiety (OR 4.26,</td></tr></table>

      Table 2: Resources

      <table><tr><td style="min-width:100px;text-align:center; padding-top:4px;" colspan="2">Software and Algorithms</td></tr><tr><td style="min-width:100px;text=align:center">Sentences</td><td style="min-width:100px;text-align:center">Resources</td></tr><tr><td style="min-width:100px;vertical-align:top;border-bottom:1px solid lightgray">Statistical Analysis The data collected in KoBo Collect software were downloaded into Excel Windows 10, cleaned and then transferred into SPSS (version 23.0 for Windows) for analysis.</td><td style="min-width:100px;border-bottom:1px solid lightgray"> <div style="margin-bottom:8px"> <div>SPSS</div> <div>suggested: (SPSS, SCR_002865)</div> </div> </td></tr></table>

      Data from additional tools added to each annotation on a weekly basis.

      About SciScore

      SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.

    1. scan comparing large, medium, and small ground finches and tree finches (Table 1) identified seven independent genomic regions with consistent genetic differentiation (ZFST > 5) in each contrast (Fig. 2A and table S2).

      Researchers performed pairwise, genome-wide fixation index (see definition in Glossary section) scans across the whole genome. They did this with 15kb windows that were non-overlapping regions.

      The following three comparisons were made: 1) large ground/tree versus medium ground/tree; 2) large ground/tree versus small ground/tree; and 3) medium ground/tree versus small ground/tree.

      A compilation of SNP calls yielded 44,767,199 variable sites within or between populations. The fixation index score ranged from zero (complete sharing of genetic material) to one (no sharing of genetic material).

      Each index value was then transformed into a Z-score, which is simply a measure of how many standard deviations below or above the population mean a raw score is. Further analysis was done if the Z-score of the fixation index was greater than five. See the Supplementary Materials for more information.

    1. python -m easy_install C:\Users\Prosserc\Downloads\QSTK-0.2.6-py2.7.egg

      it copy the .egg to site-package but not unzip the .egg because .egg can really run directly. The problem is data files in the .egg needs setuptools API to access and that's an extra effort besides I don't know how to know if my module is run from from .egg !! So, I want to install .egg means I want it to be unzipped to site-package. How?

    1. Download: Free

      This download link directs to the official website unlike many other tech websites it saw. Be careful from which site you download nox guys. Atleast till now i think bignox.com is the official website. There are so many other "unofficial" sites that just have a small note at the end saying that it is not the official site. Anyhow good job Beebom.