340 Matching Annotations
  1. Last 7 days
  2. Mar 2024
  3. Feb 2024
    1. Am 22. Februar hat Michel Forst, Beichterstatter der Vereinten Nationen zur Aarhus-Konvention, die ZAD (zone à défendre) besucht, die zur Verhinderung des Baus der Autobahn A69 zwichen Toulouse und Castres eingerichtet wurde. Die Aktivist:innen haben bei der UNO eine Beschwerde gegen die Repression durch die Behöden eingelegt. Forst forderte eine Beruhigung der Situation, damit „die Umweltdemokratie ausgeübt werden kann“.

      https://www.liberation.fr/environnement/climat/un-rapporteur-de-lonu-au-chevet-des-militants-opposes-a-la69-20240222_NDMNZTLG7REL7HFU2WZ5M3AB6A/

    1. Eine neue Studie der Universität für Bodenkultur beziffert erstmals, wieviel Kohlenstoff zwischen 1900 und 2015 langfristig oder kurzfristig in menschlichen Artefakten wie Gebäuden gespeichert wurde. Die Menge des dauerhaft gespeicherten Kohlenstoffs hat sich seit 1900 versechzehnfacht. Sie reicht aber bei weitem nicht aus, um die globale Erhitzung wirksam zu beeinflussen. Die Möglichkeiten, Boot in Gebäuden zu nutzen, um der Atmosphäre CO2 zu entziehen, werden bisher nicht genutzt. https://www.derstandard.at/story/3000000208522/co2-entnahme-durch-holzbau-ist-bisher-nicht-relevant-fuer-den-klimaschutz

      Studie: https://iopscience.iop.org/article/10.1088/1748-9326/ad236b

    1. Erneuerbare Energien sind der wichtigste Treiber des Wirtschaftswachstums in China. Zugleich droht China die Klimaziele für 2025 zu verfehlen. 2023 hat der Energieverbrauch um 5,7% zugenommen. Zwischen 2021 Uhr und 2023 wuchsen die CO2-Emissionen jährlich um durchschnittlich 3, 8%. Ein Hauptgrund dafür ist die Stimulierung der Wirtschaft in China selbst und den Ländern, in die China exportiert, nach der Covid-Krise. https://www.theguardian.com/environment/2024/feb/22/growth-in-co2-emissions-leaves-china-likely-to-miss-climate-targets

  4. Jan 2024
    1. Das Handelsblatt hat be McKinsey eine Studie zu den Kosten der Energiewende in Deutschland in Auftrag gegeben. Danach ließen sich u.a. die Kosten bis 2035 um 100 Milliarden Euro reduzieren, wenn weniger auf Solar- und Windenergie und den dazu nötigen Ausbau der Stromnetze gesetzt würde und mehr auf Gaskraftwerke, die dann auf Wasserstoff umgerüstet werden können. Der Artikel berichtet nicht über Konsequenzen für die CO<sub>2</sub>-Bilanz. https://www.handelsblatt.com/politik/deutschland/milliarden-ersparnis-sind-die-ausgaben-fuer-die-energiewende-zu-hoch/100002547.html

    1. Bologna hat am 16. Jänner fast überall im Stadtgebiet eine Höchstgeschwindigkeit von 30 Stundenkilometern eingeführt - vor allem, um die Sicherheit im Straßenverkehr zu erhöhen. Der rechtspopulistische Infrastrukturminister Salvini von der Lega versucht diese Maßnahme teilweise rückgängig zu machen. Die Entwicklung in Bologna wird für viele andere italienische Städte Modellcharakter haben. https://www.repubblica.it/green-and-blue/2024/01/22/news/bologna_30_km_ora_proteste_mobilita_limite_velocita-421938294/

  5. Dec 2023
    1. Der Standard fasst Berichte der WMO, des europäischen Wetterdienstes Copernicus und des Österreichischen Alpenvereins zum Schwund der Gletscher 2022 zusammen. Die europäischen Alpengletscher verloren 2022 mehr als 5 Kubikkilometer Eis. Die Schweizer Alpengletscher haben in 20 Jahren ein Drittel ihres Eises eingebüßt. Bei einer Temperaturerhöhung um 2,7° bis 2100 würde allein durch das fast vollständige Abschmelzen der Gletscher in Mitteleuropa, den USA, Westkanada und Neuseeland der Meeresspiegel um 115mm steigen.

      https://www.derstandard.de/story/2000145833249/die-gletscher-schmolzen-2022-im-rekordtempo-besonders-in-europa

      Infografik: https://b.staticfiles.at/elm/static/2023-04-schneeanomalie/index.html?nc9238cb923b983a

    1. Wegen anhaltendem Wassermangel können im Augenblick nur hab so viele Schiffe den Panama durchqueren wie normalerweise Punkt für die Schleusen des Kanals werden große Mengen Süßwasser benötigt. Die niederschlagsmuster verändern sich deutlich. Es ist aber noch nicht abzusehen, wie die zukünftige Entwicklung aussehen wird. Ein Beispiel für das unkartierte Gelände, in das die globale Erhitzung geführt hat. https://www.theguardian.com/environment/2023/dec/22/changing-climate-casts-a-shadow-over-the-future-of-the-panama-canal-and-global-trade

    1. What the research I’ve described here makes clear, I hope, is that the trajectory that children’s lives follow can sometimes be redirected by things that might at first seem, to the adults in their lives, to be small and insignificant. The tone of a parent’s voice. The words a teacher writes on a Post-it note. The way a math class is organized. The extra time that a mentor or a coach takes to listen to a child facing a challenge. Those personal actions can create powerful changes, and those individual changes can resonate on a national scale.

      This is a great argument for the importance of a teacher's work. Through small acts, they can make a profound difference.

    2. “Deeper learning has historically been the province of the advantaged — those who could afford to send their children to the best private schools and to live in the most desirable school districts,”

      This reminds me of the John Dewey quote: "What the best and wisest parent wants for his child, that must we want for all the children of the community. Anything less is unlovely, and left unchecked, destroys our democracy.”

    3. 22. Deeper Learning

      I appreciate how helping children succeeding is encouraging us to think about providing more engaging learning opportunities.

  6. Nov 2023
    1. Jedes Zehntel Grad weiterer Temperaturerhöhung drängt 140 Millionen Menschen - vor allem in ärmeren Regionen - aus der sogenannten Klimatische, in der Menschen gut leben können. Forschende haben genau berechnet, wie viele Menschen bei verschiedenen Klimaszenarien in so heißen Gebieten leben würden, dass sie mit hoher Wahrscheinlichkeit zur Emigration gezwungen werden. Bei dem derzeit wahrscheinlichen 2,7 Grad-Szenario für 2100 wären das bis 2030 ca 2 Milliarden Menschen, bei einem 1,5 Gra-Pfad 400 Millionen. Auch in den nicht ganz so heißen Gebieten wird die Zahl der Extremwetterereignisse weiter zunehmen. https://www.theguardian.com/environment/2023/may/22/global-heating-human-climate-niche

    1. Die europäischen Produzenten von Windturbinen machen enorme Verluste. Die Hauptgründe sind Kostensteigerungen und logistische Probleme. Hinzu kommen Investitionen für neue, stärkere Modelle und chinesische Konkurrenz. Ein zusätzliches Risiko könnte die Förderung der US-Turbinen-Industrie durch die Biden-Administration darstellen. Die europäischen Produzenten erwarten mehr Unterstützung durch die Regierungen, um Kompetenzen in Europa zu halten.

  7. Oct 2023
    1. Die Bewegung gegen die Autobahn A69, zu der auch Extinction Rebellion gehört, organisiert in einem Ort namens La Crémade eine ZAD (Zone à défendre, zu verteidigende Gebiet). Dazu wurden für den Autobahnbau bereits enteignete Gebäude besetzt, obwohl die Exekutive die Dächer beseitigt und großflächig Mist verstreut hatte, um die Aktivist:innen abzuschrecken. Die Exekutive vertrieb die Protestierenden gewaltsam. Reportage in der Libération. https://www.liberation.fr/environnement/a69-les-gendarmes-mobiles-tentent-de-demanteler-la-zad-des-opposants-20231022_YHXQJTFNOBAMBESFWFPXBWSG7Y/

  8. Sep 2023
  9. May 2023
    1. ingenuity

      skill or cleverness in devising or combining 聰明才智

    2. Licentiate

      中文翻譯:取得執照, meaning: "a person who has a license granted especially by a university to practice a profession."

    3. vanquish

      overcome or defeated in battle or in a conflict or contest 征服

    4. curate

      中文翻譯:策畫, meaning: "it means to carefully select, organize, and present a collection of items or information." Synonym: Select, Arrange, Organize.

    5. divinity

      the quality or state of being godlike 神性

    6. chivalry

      中文翻譯:騎士精神, meaning: "a code of conduct with medieval knighthood and the ideals of medieval knights." Synonym: Knightliness, Gallantry, Nobility.

    7. conceits

      excessive appreciation of one's own worth or virtue 自負

    8. aptly

      中文翻譯:恰當地, meaning: "in a way that is fitting or appropriate in conditions." Synonym: accordingly, duly, judiciously.

    9. harangue

      中文翻譯:長篇大論, meaning: "a lengthy and forceful speech or verbal attack." Synonym: Tirade, Diatribe, Rant.

    10. lucidity

      clearness of thought or style 清晰明瞭

  10. Apr 2023
    1. My favorite is always changing. Any Smith-Corona Sterling or Silent is a gem. Any Hermes, either the green or tan, all work like lightning. I have a thing for my Olivetti Lettera 22’s, as they are masterpieces of design, the action is crazy fast and light, and the typewriter is in the Museum of Modern Art.

      —Tom Hanks in TribLive 2020-05-22 at https://web.archive.org/web/20200522085215/https://archive.triblive.com/aande/books/tom-hanks-on-his-love-of-typewriters-and-the-free-press/


      I've seen several sites and listings for Smith-Corona typewriters which mention this interview quote.

  11. Mar 2023
    1. sonorous

      having a deep, pleasant sound (聲音)渾厚的

    2. it was not right thata horse belonging to a knight so famous, and one with such merits of his own, should be without some distinctivename

      The question of identity is always intriguing.

    3. ed away by theintense enjoyment he found in these pleasant fancies, he sethimself forthwith to put his scheme into execution

      This is what I like about Don Quixote. He think of what he wants to do first and execute it, instead of what he can do, because I know that if I only think of what I can do in the beginning, then I will achieve nothing.

    4. In short, his wits being quite gone, he hit upon the strang-est notion that ever madman in this world hit upon, and thatwas that he fancied it was right and requisite, as well for thesupport of his own honour as for the service of his country,that he should make a knight-errant of himself,

      Mostly, ambition is perceived as mad, but being mad is not always a bad thing.

    5. curate

      a priest of the lowest rank, especially in the Church of England, whose job is to help the vicar (= priest of a particular area) (尤指英國國教會的)助理牧師

    6. mutton

      the meat from a goat or sheep eaten as food 羊肉,山羊肉

  12. Oct 2022
    1. Sometimes a Scrum Team is hired and assembled fully by an organization without any input from the Scrum Team members, and there's nothing in Scrum preventing that. Likewise, there is nothing in Scrum that prevents a group of people from forming their own Scrum Team and organizing themselves into a structure that gives them their best shot at achieving the organization's goals.

      the Scrum Team may be both assembled or self-assembled

    2. In Scrum, the Product Owner manages the Product Backlog, Scrum Masters manage Scrum's effectiveness, and Developers manage how Increments are created.

      this is important, who is accountable for the management of what

    1. who

      is it really about who (customer/user) we're working for? or can we say that it's about what (goal/value/outcome /impact) we're working for?

  13. Sep 2022
    1. If you are an American, you must allow all ideas to circulate freely in your community, not merely your own

      I agree with this. All ideas should be expressed and taught in school regardless because that is reality. The world is filled with all different thoughts, beliefs, and ideals, so I would think that schools would want to use all different types of novels and books that express this and can teach young people what others experience in real life.

    2. ratlike people who enjoy making money from poisoning the minds of young people

      I find it sad how the school thought that it was okay to burn books and think just because they thought of them as “evil” and “poisonous”. I don’t understand how the school does not rather appreciate different perspectives and types of books, which can truly be a great learning experience.

    1. 1.9 Title: ​DFAT Country Information Report: Sri Lanka Source: Australia. Department of Foreign Affairs and Trade. Date of Document: 23 December 2021 URL: https://www.dfat.gov.au/sites/default/files/country-information-report-sri-lanka.pdf Accessed Date: 16 May 2022

      UPDATED

    2. 1.8 Title: The impact of the COVID-19 pandemic, including on detention conditions, access to justice and socio-economic conditions in major cities (2019–May 2021) Code: LKA200596.E Source: Immigration and Refugee Board of Canada Date of Document: 7 May 2021 URL: https://irb-cisr.gc.ca/en/country-information/rir/Pages/index.aspx?doc=458345 Accessed Date: 26 May 2021

      RE-NUMBERED - PREVIOUSLY 1.14

    3. 1.7 Title: ​Présentation de Sri Lanka Source: France. Ministère de l'Europe et des Affaires étrangères. Date of Document: 18 February 2021 URL: https://www.diplomatie.gouv.fr/fr/dossiers-pays/sri-lanka/presentation-du-sri-lanka/ Accessed Date: 16 May 2022

      NEW FOR 2022

    4. 1.5 Title: ​Sri Lanka Development Update: Economic and Poverty Impact of COVID-19 Source: The World Bank Date of Document: June 2021 URL: https://thedocs.worldbank.org/en/doc/15b8de0edd4f39cc7a82b7aff8430576-0310062021/original/SriLanka-DevUpd-Apr9.pdf Accessed Date: 16 May 2022

      NEW FOR 2022

    5. 1.4 Title: ​Sri Lanka. BTI 2022 Country Report. Source: Bertelsmann Stiftung Date of Document: February 2022 URL: https://bti-project.org/en/reports/country-report/LKA Accessed Date: 16 May 2022

      UPDATED

    6. 1.2 Title: ​Sri Lanka. The World Factbook. Source: United States. Central Intelligence Agency Date of Document: 10 May 2022

      UPDATED Not available as this is a constantly-updated page and no archived version of 10 May 2022 seems to exist - 24 May 2022 is closest: https://web.archive.org/web/20220526114553/https://www.cia.gov/the-world-factbook/countries/sri-lanka/

    7. 2.4 Title: ​Sri Lanka. World Report 2022: Events of 2021. Source: Human Rights Watch Date of Document: January 2022 URL: https://www.hrw.org/world-report/2022/country-chapters/sri-lanka Accessed Date: 16 May 2022

      UPDATED

    8. 2.3 Title: ​Sri Lanka. Freedom in the World 2022. Source: Freedom House Date of Document: 2022 URL: https://freedomhouse.org/country/sri-lanka/freedom-world/2022 Accessed Date: 16 May 2022

      UPDATED According to ECOI was published 3 March 2022. ECOI link: https://www.ecoi.net/en/document/2046539.html

    1. They are tangible, personal and real, in every sense of the word.

      I agree that letters are personal and real; they show you care and want to put more effort into the conversation.

    2. For those few minutes, you will live entirely in the present moment and in the thoughts you're putting on paper

      I love the aspect of being more in the present when writing something to someone through a letter, which truly expresses how you feel and think at the time.

    3. Research has shown that the general act of writing by hand can promote quite a few physical and mental benefits

      in middle school letter writing helped me feel less alone when my best friend moved to California. We wrote letters to each other because i did not have a phone, so I was able to stay in touch.

    1. Even those aware of the manipulation still felt propaganda’s pull

      I was shocked how Tokyo rose tried to persuade Japanese and Nazi causes through a radio station and the GI’s were encouraged to stop fighting, as the radios claims were false.

    2. It was best to appeal directly to the emotions

      this is scary how manipulative US propaganda is; Seeing colorful misleading posters everywhere, implied that becoming a troop will be an “honor” to America but they were false visuals with no truth in how much death was actually occurring.

    1. I live in a world of death

      this was the most moving quote. Showing the true emotion of Aanenson, it makes you understand the reality of the war and the impact it had on the troops’ lives. They were surrounded by death and destruction most of their time serving and it eventually became hard to continue to have positivity and hope when writing. Living with constant fear of your life and the life of others that can be taken away at any point; it hard to keep inside. Although Aanenson wanted to initially reveal how he was truly feeling to the girl he loved, he knew it was best to not tell her, as she cannot prevent or do anything about it. He didn’t send the letter to keep his hope in their future. These troops crave comfort from their loved ones and writing letters probably relieves some of their suffering at least a little bit. Keeping messages and letters from family and friends allows them hold on to something that they know will always be safe with and bring them joy from reading it, so it was probably best to always write with positive outlooks in order to keep the hope and dreams of a better future and end to the war.

    2. Every day I hear of some person doing strange things

      This revealed the truth behind how people had felt in the Japanese imprisonment camps. Being confined caused people to loose themselves and get caught up in negative thoughts. Forced into camps, people needed to endure the emotional and mental trauma of this, which clearly changed people.

    3. We couldn't have won the war without it. It was terribly important as a motivator of the troops

      This is my favorite quote from this article. It reveals how important and valued letters were to the soldiers and families/friends at home who received them. The troops specifically probably held on to them, treasuring what was from their loved ones, giving them hope and a drive to keep fighting in order to go home to them.

    1. In the coming years more newsreels and photographs were released showing increasingly graphic images of death and destruction

      graphic movies and films of the war horrified people and I find it interesting how effective and powerful they were to engraving scary truths of what troops were actually living through.

    2. These sources played a vital role in connecting the home front with the war front and kept Americans informed about the progress of the fighting overseas as well as its impact on their communities

      This is an impactful meaning behind the radios and movies. They showed the true reality of what troops were going through and how everyone needs to keep having hope. Even though this caused worry, it also kept everyone informed and not clueless to what was occurring.

  14. Aug 2022
    1. so almost paradoxically, projects might want to reduce liquidity for the sake of protecting governance.

      the same reversal can be found in the decreasing the value of an attack approach: incentives for an attack are aligned with the DAO success.

  15. Mar 2022
    1. which by Geber is called white lead, who teachethteaches allsoalso, which way SaturneSaturn may by washing with Mercury be converted into Jupiter

      This seems to be directly related to the epigram. More specifically where the epigrams states that "The livid Spots of Saturn's face correct, And make as white as Snow: when this is done." This seems to describe a process where Mercury is transformed through a process with some element related to Saturn

  16. Feb 2022
    1. That’s because setting policy around fake information that’s not seeded by a hostile state actor or a spam page remains an issue platforms are still deciding how to handle. YouTube chose to remove the video; Facebook chose to leave it up, and to leverage the “inform” approach (from its “remove, reduce, inform” framework).

      Why are platforms such as Facebook deciding to leave this inaccurate information up on their site? Although Facebook isn't a news site they still should not encourage the spread of doctored information by allowing it to stay public.

  17. Nov 2021
  18. Oct 2021
  19. Sep 2021
  20. Aug 2021
    1. RRID:IMSR_CRL:22

      DOI: 10.1016/j.neuron.2017.09.009

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1523/JNEUROSCI.0254-18.2018

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1016/j.stem.2018.11.005

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

  21. Jul 2021
    1. RRID:IMSR_CRL:22

      DOI: 10.1523/ENEURO.0475-18.2019

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @scibot

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1002/cne.24683

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @Naa003

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1111/jnc.14561

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @Jmenke

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. CRL:22

      DOI: 10.1210/en.2017-03109

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @evieth

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    2. CRL:22

      DOI: 10.1210/en.2017-03109

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @evieth

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    3. RRID:IMSR_CRL:22

      DOI: 10.1210/en.2017-03109

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @evieth

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

  22. May 2021
    1. It's a chicken-and-egg-like problem: If we use module: 'commonjs', then if any TS files import ES Modules (indirectly in their dependency graph), then Node throws an error because CommonJS modules can not import ES Modules.
  23. Apr 2021
  24. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 4.4

      AssayResultAssertion: Normal

      StandardErrorMean: 0.39

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.2014G>C p.(Glu672Gln)

    1. SUPPLEMENTARY DATA

      AssayResult: 23.6

      AssayResultAssertion: Abnormal

      PValue: < 0.0001

    2. SUPPLEMENTARY DATA

      AssayResult: -56

      AssayResultAssertion: Abnormal

      PValue: < 0.0001

    3. SUPPLEMENTARY DATA

      AssayResult: 57.61

      AssayResultAssertion: Abnormal

      PValue: < 0.0001

      Comment: Exact values reported in Table S3.

    4. To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).

      HGVS: NM_024675.3:c.3089C>T p.(Thr1030Ile)

    1. Source Data

      AssayResult: 86.54

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardErrorMean: 11.96

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 91.6

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardDeviation: 8.2

      StandardErrorMean: 5.8

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.2590C>T p.(P864S)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 117.2

      AssayResultAssertion: Abnormal

      ReplicateCount: 36

      StandardErrorMean: 11.7

      Comment: This variant had normal peak current and increased late current (>1% of peak), therefore it was considered a GOF variant (in vitro features consistent with Long QT Syndrome Type 3). (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.2441G>A p.(Arg814Gln)

  25. Feb 2021
    1. Supplemental material

      AssayResult: 83

      AssayResultAssertion: Normal

      Comment: See Table S2 for details

    2. Supplemental material

      AssayResult: 3.5

      AssayResultAssertion: Abnormal

      Comment: See Table S2 for details

    3. We analysed a total of 82 blood samples derived from 77 individuals (online supplemental table 3). These 77 individuals corresponded either to new index cases suspected to harbour a pathogenic TP53 variant or to relatives of index cases harbouring TP53 variants.

      HGVS: NM_000546.5:c.523C>G p.(Arg175Gly)

  26. Jan 2021
    1. Kerry, the former US secretary of state, acknowledged that America had been absent from the international effort to contain dangerous global heating during Donald Trump’s presidency but added that “today no country and no continent is getting the job done”.
    1. the behavior you want happen is actually a chicken and egg situation, you need to initialise FancyList in order to get the value for let:prop from the FancyList, however you can't initialise FancyList without the value of id which comes from within FancyList.
  27. Dec 2020
  28. Oct 2020
    1. The backlash from gig economy companies was immediate, and Uber and similar app-based businesses have committed nearly $200 million to support a state ballot measure — making it the costliest in state history — that would exempt them from the law.

      This is a pretty good indicator that it will save them 10x to 100x this amount to get rid of this law.

      One should ask: "Why don't they accept it and just pass this money along to their employees."

  29. Sep 2020
  30. May 2020
    1. Mozilla does not permit extensions distributed through https://addons.mozilla.org/ to load external scripts. Mozilla does allow extensions to be externally distributed, but https://addons.mozilla.org/ is how most people discover extensions. The are still concerns: Google and Microsoft do not grant permission for others to distribute their "widget" scripts. Google's and Microsoft's "widget" scripts are minified. This prevents Mozilla's reviewers from being able to easily evaluate the code that is being distributed. Mozilla can reject an extension for this. Even if an extension author self-distributes, Mozilla can request the source code for the extension and halt its distribution for the same reason.

      Maybe not technically a catch-22/chicken-and-egg problem, but what is a better name for this logical/dependency problem?

  31. Mar 2020
    1. To complicate things further, if you classify your social-sharing-plugins-usage as required functionality, and those need to set their own 3rd party cookies (as they themselves classify those as required), hello to 3rd party cookies being set by default and no way for users to opt-out (except by turning them off via browser, which means the whole thing is redundant, might as well just instruct users to disable third party cookies if they don't want to participate in social sharing crap?)
    1. Also note that the first two opt out tools are currently cookie-based and prevent Oracle from using, sharing, or selling your personal information for interest-based advertising on the browser on which they are installed. As a result, the opt out will only function if your browser is set to accept third-party cookies and may not function where cookies are sometimes automatically disabled or removed (e.g., certain mobile devices and operating systems). If you delete cookies, change your browser settings, switch browsers or computers, or use another operating system, you will need to opt out again. Oracle does not use persistent, unique identifiers to revive a previously opted-out profile or deleted cookie.
    1. Note that the scope of personal data is truly broad, which makes processing complex and tricky. So, even though, for instance, you employ anonymization in Google Analytics to get rid of all information that falls under this category, you’re still in a catch-22 situation. This is because GA stores a visitor online identifier in a cookie, and under the GDPR that file constitutes a piece of personal data. That means you still need to obtain consent from visitors to process their data.
  32. Jan 2020
    1. That's the problem with therapy: The people who really need help are often the onesnot trusting others (as a result of bad experiences)not recognizing they have a problem in the first placebeing too scared to open up (or leave the house)being too exhausted to goless likely to be able to afford it. (That's only an issue in countries without a proper health care system.)
    1. RRID:IMSR_CRL:22

      DOI: 10.1111/bph.14683

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @Naa003

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1016/j.cell.2019.02.010

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @ethanbadger

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1002/cne.24683

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @Naa003

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.7554/eLife.42298

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @evieth

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1016/j.ydbio.2018.11.014

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @ethanbadger

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1111/jnc.14561

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @Jmenke

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

    1. RRID:IMSR_CRL:22

      DOI: 10.1016/j.neuron.2019.01.022

      Resource: (IMSR Cat# CRL_22,RRID:IMSR_CRL:22)

      Curator: @ethanbadger

      SciCrunch record: RRID:IMSR_CRL:22


      What is this?

  33. Jun 2019