1,069 Matching Annotations
  1. Mar 2020
  2. chemrxiv.org chemrxiv.org
    A Single and Two-Stage, Closed-Tube, Molecular Test for the 2019 Novel Coronavirus (COVID-19) at Home, Clinic, and Points of Entry
    1
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    chemrxiv.org/articles/A_Single_and_Two-Stage_Closed-Tube_Molecular_Test_for_the_2019_Novel_Coronavirus_COVID-19_at_Home_Clinic_and_Points_of_Entry/11860137/1
  3. www-nature-com.ezproxy.rice.edu www-nature-com.ezproxy.rice.edu
    Characterization of 582 natural and synthetic terminators and quantification of their design constraints
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    www-nature-com.ezproxy.rice.edu/articles/nmeth.2515
  4. Feb 2020
  5. osf.io osf.io
    Sear_life history strategies_EHB.pdf
    1
    1. alcanthro 27 Feb 2020
      there is littleelse on this list which can be considered part of a life history strategy if ‘life history’ is meant to be anchored in evolutionary biological research

      Isn't altruism, the willingness and ability to sacrifice for kin, the rate of drop-off of willing altruism, etc all directly connected to evolutionary biology?

      evolutionary biology altruism
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    osf.io/hjezb/
  6. Jan 2020
  7. parts.igem.org parts.igem.org
    Part:BBa B0040 - parts.igem.org
    1
    1. pbk1 13 Jan 2020
      A spacer could compensate for any steric hindrance effect on recruiting the transcriptional machinery at the promoter of the next module in the assembly line; such an effect could be induced by the supercoiling that results when the transcription of the previous module is taking place. However, there is no direct evidence that this may cause a problem, and therefore the argument in favor of using a spacer remains speculative.
      spacer synthetic biology
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    parts.igem.org/Part:BBa_B0040
  8. www.octant.bio www.octant.bio
    OCTOPUS: A simple, low-cost plasmid sequencing method — Octant
    2
    1. pbk1 07 Jan 2020
      More broadly, we hope that others, especially the hundreds of new startups in synthetic biology, consider sharing pre-competitive ideas, methods, tools, etc. We think the community will be stronger as a result.

      This is a great initiative. Hat's off to this company - Octant-bio for encouraging open sourcing of their hard work and optimization.

      open source synthetic biology
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    octant.bio/blog/2019/9/29/octopus
  9. www-sciencedirect-com.ezproxy.rice.edu www-sciencedirect-com.ezproxy.rice.edu
    Transcription factor-based biosensors and inducible systems in non-model bacteria: current progress and future directions
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    www-sciencedirect-com.ezproxy.rice.edu/science/article/pii/S0958166919300783
  10. www.lesswrong.com www.lesswrong.com
    Book Review: Design Principles of Biological Circuits - LessWrong 2.0
    1
    1. pbk1 06 Jan 2020
      A final word: when we do not understand something, it does not look like there is anything to be understood at all - it just looks like random noise. Just because it looks like noise does not mean there is no hidden structure.

      Excellent statement! Could this be the guiding principle of the current big data boom in biology?

      noise systems biology big data
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    lesswrong.com/posts/bNXdnRTpSXk9p4zmi/book-review-design-principles-of-biological-circuits
  11. Dec 2019
  12. frankensteinvariorum.github.io frankensteinvariorum.github.io
    Frankenstein (1818)
    2
    1. frankensteinvariorum 16 Dec 2019
      blood circulate

      The early modern English physician William Harvey (1578-1627) made several valuable contributions to the medical sciences, including the circulation of blood in the human body. In De Motu Cordis (1628), Harvey sets down his landmark experiments; in these, Harvey used ligatures to stem blood flow to better understand how the heart works to pump blood throughout the human body. This knowledge will be critical for Victor's creation of the Creature.

      medicine biology science jk
    2. frankensteinvariorum 16 Dec 2019
      physiology

      By 1818 physiology had become a controversial branch of medicine at the center of the dispute between vitalism, the idea that a divine spark energized animal life, and materialism, the argument that chemical processes alone give rise to life. Mary Shelley was well aware of the dispute since the Shelleys' family doctor, William Lawrence, was vigorously taking up the materialist argument in works like An Introduction to Comparative Anatomy and Physiology (1816). For a full view of this controversy as it relates to the novel, see Marilyn Butler, "Frankenstein and Radical Science" [1993] reprinted in J. Paul Hunter, Frankenstein, Norton Critical Edition, second ed. (New York: Norton, 2012): 404-416.

      medicine biology anatomy science jk
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    frankensteinvariorum.github.io/fv-collation/Frankenstein_1818.html
  13. Nov 2019
  14. www.biorxiv.org www.biorxiv.org
    Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis
    1
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    biorxiv.org/content/10.1101/651182v2
  15. www.biorxiv.org www.biorxiv.org
    Sufficiency analysis of estrogen responsive enhancers using synthetic activators
    1
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    biorxiv.org/content/10.1101/479709v2
  16. www.biorxiv.org www.biorxiv.org
    Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity
    1
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    biorxiv.org/content/10.1101/704882v1
  17. www.biorxiv.org www.biorxiv.org
    Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1
    1
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    biorxiv.org/content/10.1101/509976v1
  18. www.biorxiv.org www.biorxiv.org
    Combinatorial prediction of gene-marker panels from single-cell transcriptomic data.
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    biorxiv.org/content/10.1101/655753v2
  19. www.biorxiv.org www.biorxiv.org
    High affinity interactions and signal transduction between Aβ oligomers and TREM2
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    biorxiv.org/content/10.1101/269787v1
  20. www.biorxiv.org www.biorxiv.org
    Pannexin-1 Channels govern the Generation of Necroptotic small Extracellular Vesicles
    1
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    biorxiv.org/content/10.1101/537753v1
  21. www.biorxiv.org www.biorxiv.org
    Long-term expanding human airway organoids for disease modelling.
    1
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    biorxiv.org/content/10.1101/318444v1
  22. www.biorxiv.org www.biorxiv.org
    Estrogen receptor alpha controls gene expression via translational offsetting
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    biorxiv.org/content/10.1101/507574v1
  23. www.biorxiv.org www.biorxiv.org
    Paralog dependency indirectly affects the robustness of human cells
    1
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    biorxiv.org/content/10.1101/552208v3
  24. www.biorxiv.org www.biorxiv.org
    Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions
    1
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    biorxiv.org/content/10.1101/299073v3
  25. www.biorxiv.org www.biorxiv.org
    An integrated workflow for cross-linking/mass spectrometry
    1
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    biorxiv.org/content/10.1101/355396v2
  26. www.biorxiv.org www.biorxiv.org
    Elucidation of the viral disassembly switch of tobacco mosaic virus
    1
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    biorxiv.org/content/10.1101/569178v1
  27. www.biorxiv.org www.biorxiv.org
    Toward a genetic system in the marine cyanobacterium Prochlorococcus
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    biorxiv.org/content/10.1101/820027v1
  28. www-nature-com.ezproxy.rice.edu www-nature-com.ezproxy.rice.edu
    Abundance determines the functional role of bacterial phylotypes in complex communities
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    www-nature-com.ezproxy.rice.edu/articles/s41564-018-0180-0
  29. www.biorxiv.org www.biorxiv.org
    Synthetic gene regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae
    2
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    biorxiv.org/content/10.1101/834689v1
  30. Oct 2019
  31. www.aeesp.org www.aeesp.org
    Department of Civil and Environmental Engineering - Open Rank Faculty Positions | AEESP
    1
    1. pbk1 29 Oct 2019
      includes creation of innovative solutions for bio energy, resource recovery, and emerging public health concerns by leveraging synthetic or molecular biology tools, novel biological systems (genetic circuits, enzymes, genetically engineered microbes), fundamental biological and chemical concepts, artificial intelligence, and big data science, as well as collaborations in Computer Science, Public Health, Plant Biology, or related fields.
      synthetic biology applications
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    aeesp.org/jobs/3150
  32. bullets.news bullets.news
    (Summary) Study: Ants are “immune” to traffic jams
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    bullets.news/s/894
  33. Sep 2019
  34. www.biorxiv.org www.biorxiv.org
    let-7 controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41
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    biorxiv.org/content/10.1101/460352v1
  35. www.biorxiv.org www.biorxiv.org
    Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission
    1
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    biorxiv.org/content/10.1101/686568v2
  36. www.biorxiv.org www.biorxiv.org
    Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC
    1
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    biorxiv.org/content/10.1101/531236v1
  37. www.biorxiv.org www.biorxiv.org
    The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells
    1
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    biorxiv.org/content/10.1101/460816v3
  38. www.biorxiv.org www.biorxiv.org
    Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutants
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    biorxiv.org/content/10.1101/519991v1
  39. www.biorxiv.org www.biorxiv.org
    Hierarchical organization of the human cell from a cancer coessentiality network
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    biorxiv.org/content/10.1101/328880v1
  40. www.biorxiv.org www.biorxiv.org
    The chaperone-client network subordinates cell-cycle entry to growth and stress
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    biorxiv.org/content/10.1101/485714v1
  41. www.biorxiv.org www.biorxiv.org
    Maternal Circulating MicroRNAs Control the Placental Response to Alcohol
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    biorxiv.org/content/10.1101/409854v3
  42. www.biorxiv.org www.biorxiv.org
    Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association
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    biorxiv.org/content/10.1101/561977v1
  43. www.biorxiv.org www.biorxiv.org
    Human DNA polymerase delta is a pentameric complex with dimeric p12 subunit: Implications in enzyme architecture and PCNA interaction
    1
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    biorxiv.org/content/10.1101/525485v3
  44. www.biorxiv.org www.biorxiv.org
    PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts and white matter changes
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    biorxiv.org/content/10.1101/413070v1
  45. www.biorxiv.org www.biorxiv.org
    The small and large ribosomal subunits depend on each other for stability and accumulation
    1
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    biorxiv.org/content/10.1101/384362v1
  46. www.biorxiv.org www.biorxiv.org
    Main constraints for RNAi induced by expressed long dsRNA in mouse cells
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    biorxiv.org/content/10.1101/485524v1
  47. www.biorxiv.org www.biorxiv.org
    Rab1b and ARF5 are novel RNA-binding proteins involved in IRES-driven RNA localization
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    biorxiv.org/content/10.1101/363580v2
  48. www.biorxiv.org www.biorxiv.org
    Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1
    1
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    biorxiv.org/content/10.1101/468413v1
  49. www.biorxiv.org www.biorxiv.org
    Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4
    1
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    biorxiv.org/content/10.1101/372052v1
  50. www.biorxiv.org www.biorxiv.org
    An integrative machine learning approach for prediction of toxicity-related drug safety
    1
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    biorxiv.org/content/10.1101/455667v1
  51. www.biorxiv.org www.biorxiv.org
    Phosphorylation of Arp2 is not essential for Arp2/3 complex activity in fission yeast
    1
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    biorxiv.org/content/10.1101/372706v1
  52. www.biorxiv.org www.biorxiv.org
    Novel organelle anion channels formed by chromogranin B drive normal granule maturation in endocrine cells
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    biorxiv.org/content/10.1101/302828v1
  53. www.biorxiv.org www.biorxiv.org
    Cumulative regulatory potential of clustered methyl-arginine protein modifications
    1
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    biorxiv.org/content/10.1101/289041v2
  54. www.biorxiv.org www.biorxiv.org
    CHRAC/ACF Contribute to the Repressive Ground State of Chromatin
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    biorxiv.org/content/10.1101/218768v1
  55. www.biorxiv.org www.biorxiv.org
    Role of Cnot6l in maternal mRNA turnover
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    biorxiv.org/content/10.1101/362145v1
  56. www.biorxiv.org www.biorxiv.org
    The repressive and alleviating nature of FACT shapes the transcriptional landscape in ES cells
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    biorxiv.org/content/10.1101/251611v2
  57. www.biorxiv.org www.biorxiv.org
    Dynamic m6A methylation facilitates mRNA triaging to stress granules
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    biorxiv.org/content/10.1101/357012v1
  58. www.biorxiv.org www.biorxiv.org
    DHX15 regulates CMTR1-dependent gene expression and cell proliferation
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    biorxiv.org/content/10.1101/113209v1
  59. www.biorxiv.org www.biorxiv.org
    Co-existing feedback loops generate tissue-specific circadian rhythms
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    biorxiv.org/content/10.1101/304451v1
  60. www.biorxiv.org www.biorxiv.org
    Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
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    biorxiv.org/content/10.1101/250167v1
  61. www.biorxiv.org www.biorxiv.org
    The TRAPP complex mediates secretion arrest induced by stress granule assembly
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    biorxiv.org/content/10.1101/528380v2
  62. www.biorxiv.org www.biorxiv.org
    Actin filaments regulate microtubule growth at the centrosome.
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    biorxiv.org/content/10.1101/302190v1
  63. www.biorxiv.org www.biorxiv.org
    Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network
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    biorxiv.org/content/10.1101/090142v1
  64. www.biorxiv.org www.biorxiv.org
    The β3-integrin endothelial adhesome regulates microtubule dependent cell migration
    1
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    biorxiv.org/content/10.1101/145839v1
  65. www.biorxiv.org www.biorxiv.org
    Mapping In Vivo O-Glycoproteome Using Site-specific Extraction of O-linked glycopeptides (EXoO)
    1
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    biorxiv.org/content/10.1101/368282v1
  66. www.biorxiv.org www.biorxiv.org
    Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing
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    biorxiv.org/content/10.1101/605725v1
  67. www.biorxiv.org www.biorxiv.org
    A genetic system for generating single-sex progeny in mice
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    biorxiv.org/content/10.1101/515064v2
  68. www.biorxiv.org www.biorxiv.org
    Multiple C2 domains and Transmembrane region Proteins (MCTPs) tether membranes at plasmodesmata
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    biorxiv.org/content/10.1101/423905v1
  69. www.biorxiv.org www.biorxiv.org
    Functional systemic CD4 immunity is a differential factor for clinical responses to PD-L1/PD-1 blockade therapy in lung cancer
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    biorxiv.org/content/10.1101/508739v2
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    Disentangling bacterial invasiveness from lethality in an experimental host-pathogen system
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    biorxiv.org/content/10.1101/361584v1
  71. www.biorxiv.org www.biorxiv.org
    RASSF1A Is Required For The Maintenance Of Nuclear Actin Levels
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    biorxiv.org/content/10.1101/559310v1
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    Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice
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    biorxiv.org/content/10.1101/416479v2
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    LRX- and FER-dependent extracellular sensing coordinates vacuolar size for cytosol homeostasis
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    biorxiv.org/content/10.1101/231043v1
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    The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity
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    biorxiv.org/content/10.1101/510230v1
  75. www.biorxiv.org www.biorxiv.org
    Absolute quantification of translational regulation and burden using combined sequencing approaches
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    biorxiv.org/content/10.1101/338939v2
  76. www.biorxiv.org www.biorxiv.org
    Mechanistic causes of constrained phenotypic variation revealed by synthetic gene regulatory networks
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    biorxiv.org/content/10.1101/184325v2
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    The fitness cost and benefit of phase separated protein deposits
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    biorxiv.org/content/10.1101/574657v2
  78. www.biorxiv.org www.biorxiv.org
    Defining the RNA Interactome by Total RNA-Associated Protein Purification
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    biorxiv.org/content/10.1101/436253v1
  79. www.biorxiv.org www.biorxiv.org
    SWI/SNF chromatin remodeling controls Notch-responsive enhancer accessibility
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    biorxiv.org/content/10.1101/399501v1
  80. www.biorxiv.org www.biorxiv.org
    Asymmetric Distribution of Glucose Transporter mRNA Provides Growth Advantage
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    biorxiv.org/content/10.1101/380279v1
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    Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex
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    biorxiv.org/content/10.1101/435149v1
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    Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
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    biorxiv.org/content/10.1101/284240v2
  83. www.biorxiv.org www.biorxiv.org
    Evidence that the cell cycle is a series of uncoupled, memoryless phases
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    biorxiv.org/content/10.1101/283614v1
  84. www.biorxiv.org www.biorxiv.org
    The fungal root endophyte Serendipita indica modifies extracellular nucleotides to subvert plant immunity
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    biorxiv.org/content/10.1101/396028v1
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    netDx: Patient classification using integrated patient similarity networks
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    biorxiv.org/content/10.1101/084418v4
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    SSU72 phosphatase is a telomere replication terminator
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    biorxiv.org/content/10.1101/382564v1
  87. www.biorxiv.org www.biorxiv.org
    De novo Gene Signature Identification from Single-Cell RNA-Seq with Hierarchical Poisson Factorization
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    biorxiv.org/content/10.1101/367003v1
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    Quantification and discovery of sequence determinants of protein per mRNA amount in 29 human tissues
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    biorxiv.org/content/10.1101/353763v1
  89. www.biorxiv.org www.biorxiv.org
    A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
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    biorxiv.org/content/10.1101/357137v1
  90. www.biorxiv.org www.biorxiv.org
    Length-independent telomere damage drives cardiomyocyte senescence
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    biorxiv.org/content/10.1101/394809v1
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    Widespread inter-individual gene expression variability in Arabidopsis thaliana
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    biorxiv.org/content/10.1101/335380v2
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    Complex-centric proteome profiling by SEC-SWATH-MS
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    biorxiv.org/content/10.1101/323683v2
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    High-resolution mapping of cancer cell networks using co-functional interactions
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    biorxiv.org/content/10.1101/369751v1
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    CDK phosphorylation of Xenopus laevis M18BP1 promotes its metaphase centromere localization
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    biorxiv.org/content/10.1101/355487v1
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    Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death
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    Bimodal Spindle Orientation Drives Tissue Regularity in a Proliferating Epithelium
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    Avidity-driven polarity establishment via multivalent lipid-GTPase module interactions
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    The key protein of endosomal mRNP transport binds translational landmark sites of cargo mRNAs
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    S phase R-loop formation is restricted by PrimPol-mediated repriming
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    A common molecular logic determines embryonic stem cell self-renewal and reprogramming
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    Functional Compensation Between Hematopoietic Stem Cells In Vivo
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    Synthesis and degradation of FtsZ determines the first cell division in starved bacteria
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    Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
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    ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
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    Transcriptional control and exploitation of an immune-responsive family of retrotransposons in Arabidopsis
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    Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming
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    TRIP6 inhibits the Hippo signaling pathway in response to tension at adherens junctions
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    Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model
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    Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations
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    Ratiometric Distribution Of OCT4 During Stem Cell Division Controls The Balance Between Self-Renewal And Differentiation
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    Multi-Omics factor analysis disentangles heterogeneity in blood cancer
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    FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
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    Fibroblast state switching orchestrates dermal maturation and wound healing
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    Genomics of cellular proliferation under periodic stress
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    MODELING SIGNALING-DEPENDENT PLURIPOTENT CELL STATES WITH BOOLEAN LOGIC CAN PREDICT CELL FATE TRANSITIONS
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    Genome-wide phenotypic analysis of growth, cell morphogenesis and cellcycle events in Escherichia coli.
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    Structure of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis
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    A synthesis of over 9,000 mass spectrometry experiments reveals the core set of human protein complexes
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    A two-state photoconversion model predicts the spectral response dynamics of optogenetic systems
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    Unraveling mitotic protein networks by 3D multiplexed epitope drug screening
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    Mapping DNA damage-dependent genetic interactions in yeast via orgy mating and barcode fusion genetics
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    Redesigning chromosomes to optimize conformation capture (Hi-C) assays
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    The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization
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    GTSF-1 is required for the formation of a functional RNA-dependent RNA Polymerase complex in C. elegans
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    X10 Expansion Microscopy Enables 25 nm Resolution on Conventional Microscopes
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    Lateral plasma membrane compartmentalization links protein function and turnover
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    Deciphering microbial interactions in synthetic human gut microbiome communities
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    FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells
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    Expression variation and covariation impair analog and enable binary signaling control
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    Timing of gene expression in a cell-fate decision system
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    Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib
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    Structural centrosome aberrations promote non-cell-autonomous invasiveness
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    Photoperiodic control of the Arabidopsis proteome reveals a translational coincidence mechanism
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    A Map Of Genetic Interactions In Cancer Cells
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    Structure of the eukaryotic cytoplasmic pre-40S ribosomal subunit
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    Antisense transcription-dependent chromatin signature modulates sense transcription and transcript dynamics
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    Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
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    Assigning Function To Natural Allelic Variation Via Dynamic Modeling Of Gene Network Induction
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    Expanding the Atlas of Functional Missense Variation for Human Genes
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    WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
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    Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations
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    The Landscape Of Human Mutually Exclusive Splicing
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    From word models to executable models of signaling networks using automated assembly
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    Aubergine And piRNAs Repress The Proto-Oncogene Cbl For Germline Stem Cell Self-Renewal
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    An "invisible" ubiquitin conformation is required for efficient phosphorylation by PINK1
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    Initiation of DNA replication requires actin dynamics and formin activity
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    Combinatorial Regulation Of The Balance Between Dynein Microtubule End Accumulation And Initiation Of Directed Motility
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    CRISPR/Cas9 screening using unique molecular identifiers
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    In Situ Genotyping Of A Pooled Strain Library After Characterizing Complex Phenotypes
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    A Theory That Predicts Behaviors Of Disordered Cytoskeletal Networks
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    Remodeling of ER-exit sites initiates a membrane supply pathway forautophagosome biogenesis
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    High-throughput CRISPRi phenotyping in Streptococcus pneumoniae identifies new essential genes involved in cell wall synthesis and competence development
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    A living vector field reveals constraints on galactose network induction in yeast
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    An RNA-binding tropomyosin recruits kinesin-1 dynamically to oskar mRNPs
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    Distinct Cellular States Determine Calcium Signaling Response
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    Polarized Cortical Tension drives Zebrafish Epiboly Movements
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    An Atlas of Human Kinase Regulation
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    A population-based temporal logic gate for timing and recording chemical events
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    Determinants of RNA metabolism in the Schizosaccharomyces pombe genome
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    Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress
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    Efficient Search, Mapping, and Optimization of Multi-protein Genetic Systems in Diverse Bacteria
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    Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
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  165. blogs.ei.columbia.edu blogs.ei.columbia.edu
    How Synthetic Biology Can Help the Environment
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  166. www.forbes.com www.forbes.com
    Algal Biofuels Dead? 'Not So Fast', Says Algal Biofuel Researcher
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  167. blogs.ei.columbia.edu blogs.ei.columbia.edu
    Synthetic Biology: Creating New Forms of Life
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  168. Jul 2019
  169. medium.com medium.com
    The key lessons from “Where Good Ideas Come From” by Steven Johnson
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  170. www.theatlantic.com www.theatlantic.com
    Humans: The Hyperkeystone Species
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  171. www.theatlantic.com www.theatlantic.com
    The Disturbing Sound of a Human Voice
    1
    1. Yuxi_Liu 18 Jul 2019

      Fear of humans as apex predators has landscape-scale impactsfrom mount ain lions to mice (2019)

      Apex predators such as large carnivores can have cascading, landscape-scale impacts across wild-life communities, which could result largely from the fear they inspire, although this has yet to be experimentally demonstrated.

      Humans have supplanted large carnivores as apex predators in many systems, and similarly pervasive impacts may now result from fear of the human ‘superpredator’.

      We conducted a landscape-scale playback experiment demonstrating that the sound of humans speaking generates a landscape of fear with pervasive effects across wildlife communities.

      • Large carnivores avoided human voices and moved more cautiously when hearing humans,
      • medium-sized carnivores became more elusive and reduced foraging.
      • Small mammals evidently benefited, increasing habitat use and foraging.

      Thus, just the sound of a predator can have landscape-scale effects at multiple trophic levels.

      Our results indicate that many of the globally observed impacts on wildlife attributed to anthropogenic activity may be explained by fear of humans.

      ecology of fear ecology biology human anthropocene
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  172. Apr 2019
  173. evonomics.com evonomics.com
    How Ants Solve the Inequality Problem - Evonomics
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    evonomics.com/the-answer-is-under-your-foots-how-ants-solve-inequality/
  174. Mar 2019
  175. www.jax.org www.jax.org
    Core Competencies in Genetics
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    jax.org/education-and-learning/clinical-and-continuing-education/ccep-non-cancer-resources/core-competencies-for-health-care-professionals
  176. Feb 2019
  177. dougengelbart.org dougengelbart.org
    Augmenting Human Intellect: A Conceptual Framework - 1962 (AUGMENT,3906,) - Doug Engelbart Institute
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  178. Jan 2019
  179. www.quora.com www.quora.com
    (1) How can I start learning about systems biology? - Quora
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    1. Maciej_Motyka 09 Jan 2019
      In my opinion if you can get enrolled into a degree program for systems biology then that would be best. However, if you are just exploring the field on your own I would recommend going through these resources.Video lectures by Uri AlonVideo Lectures by Jeff GorePrinciples of Synthetic Biology (at edx)Coursera specialization on systems biology.If you are looking for mathematical intensive start with first 2 and if you are looking for biologically intensive begin with last 2. Either way go through all 4 of them as they provide diverse perspective on systems biology which is very important. As you will move through these materials all the necessary supplementary information like books, papers and softwares will be informed within these materials itself.Hope this helps!
      bioinformatics online learning systems biology
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  180. Sep 2018
  181. www.mnemotext.com www.mnemotext.com
    The Technological Singularity
    1
    1. CaseyH123 07 Sep 2018
      performance curves beginning to level off – because of our inability to automate the design work needed to support further hardware improvements. Wed end up with some very powerful hardware, but without the ability to push it further

      Addressing the question of singularity, the author takes on an interesting perspective. One rationalization or opposing view is that technology is only as informational and intelligent as the creator itself. Just as the Mores conclude, "the computational competence of single neurons may be far higher than generally believed" and that "our present computer hardware might be [] 10 orders of magnitude short [compared to] our heads". This means that AI cannot surpass human intelligence as popularly believed. Rather, the article conjectures the possibility that if singularity were to occur, further innovation and improvements could never be made. I assume this is a biological and anatomical argument. Thus, implying that the technological constraints of AI cause it to be inferior to the biological makeup of the human brain. Thus, the author suggests that singularity can never really be fully realized.

      biology technology AI innovation creativity improvement
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  182. Apr 2018
  183. sites.google.com sites.google.com
    Butte Biology
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  184. Mar 2018
  185. www.theknifemedia.com www.theknifemedia.com
    The misrepresentation of James Damore | The Knife Media
    2
    1. Perig 31 Mar 2018
      Also, the existence of differences between men and women doesn’t necessarily mean they can’t be changed in the future, even some biological ones. How much of what we’ve inherited – biologically, psychologically or socially – is outdated and malleable?  

      Expand... posthumanism?

      biology of sex differences
    2. Perig 31 Mar 2018
      There are factors other than sexism or discrimination that could in part explain why Google does not have 50 percent female representation. There are differences between men and women on average, based on population level statistics. (He qualifies this by noting a number of these differences are small and there is significant overlap between the genders.) These differences may in part explain the gender gap in tech. Women and men may differ partly because of biological reasons.

      Summary of Damore's claims.

      James Damore gender biology of sex differences
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  186. www.iflscience.com www.iflscience.com
    Scientists Just Discovered A New Human Organ, And It Could Have Huge Implications For How We Treat Cancer
    1
    1. Perig 28 Mar 2018
      This could help explain where so much of our body’s fluid goes. While our cells contain most of the fluid, and the circulatory system carries a whole load more, over a third went unaccounted for and was simply said to be “interstitial”, or just floating around between organs and cells. The researchers claim, in a paper published in Scientific Advances, that the “interstitium” should be defined as an organ in its own right.

      The interstitium, a new organ, accounts for the body's "black matter" (unaccounted for fluids).

      interstitium discovery organ biology physiology lymph fluids water
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    iflscience.com/health-and-medicine/researchers-accidentally-discover-what-could-be-an-entirely-new-organ-in-the-human-body/
  187. Dec 2017
  188. www.nature.com www.nature.com
    Statistical and integrative system-level analysis of DNA methylation data
    1
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    nature.com/articles/nrg.2017.86
  189. Apr 2017
  190. static1.squarespace.com static1.squarespace.com
    lynch_and_rivers_do_you_believe_in_rhetoric_and_composition.pdf
    1
    1. gilmanhernandez 26 Apr 2017
      perfectly fit for a blind, myopic, workaholic, trail-sniffing, and collective traveler"

      Plus, while we think of ants as a hierarchical species (Queens>Drones>Workers, etc.), Queens really only exist to pump out eggs and don't give any oversight or leadership. The entire colony functions as a complex society without anything resembling discrete, individual deciders.

      #Biology #Entomology
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  191. oup.silverchair-cdn.com oup.silverchair-cdn.com
    OP-SYNB160002 1..13
    1
    1. heatherstaines 19 Apr 2017
      approaches have proven invaluable for understanding metabo-lism and improving metabolite production (Wiechert 2002;Patilet al. 2004), metabolic engineering ‘design principles’ are yet tobe fully elucidated due to our incomplete knowledge of livingsystems. Subsequently, it can take many iterations of the classi-cal design-build-test cycle to achieve engineering objectives,some of which may even be impossible to meet using availablebiological knowledge.An elegant way to overcome the challenges associated withengineering in biology is to apply a selective pressure to a genet-ically diverse population so that cells with the desired pheno-type can be isolated.

      This is key!

      synthetic biology
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    oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/synbio/2/1/10.1093_synbio_ysw002/5/ysw002.pdf
  192. Feb 2017
  193. static1.squarespace.com static1.squarespace.com
    campbell_from_the_philosophy_of_rhetoric.pdf
    2
    1. gilmanhernandez 08 Feb 2017
      This conclusion is not founded on this single instance, but on this instance compared with a general experience of the regularity of this clement in all its operations.

      I am thinking here of Darwin's Moth, a species of moth Charles Darwin concluded must exist, from the shape of a certain orchid, 40 years before the moth itself was discovered. It is not the induction from orchid->moth, but dozens of moth-orchid interactions that lets you fill in the probable details.

      e. Actually, I think this is better an example of analogy, now that I think about it.

      e2. Moth-Orchid Dynamics would be a good name for a rock band

      #Darwin #Biology #Induction
    2. gilmanhernandez 08 Feb 2017
      But should I from the same experiment infer the circulation of the sap in vegetables, this would be called an argument only from analogy.

      Georges Canguilhem actually has a lot to say about how much of the history of physiology works under different mechanical analogies, thinking of the heart as a pump and the arm as a lever, but he cautions this, arguing that Science and Technique are two distinct things that borrow and influence each other, but are not extensions of one from the other. Still, the analogy logic of how we understand the long-standing human body in terms of the thing we just invented seems relevant here.

      #Biology
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  194. Dec 2016
  195. news.nationalgeographic.com news.nationalgeographic.com
    First Dinosaur Tail Found Preserved in Amber
    1
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    news.nationalgeographic.com/2016/12/feathered-dinosaur-tail-amber-theropod-myanmar-burma-cretaceous/
  196. Dec 2015
  197. biorxiv.org biorxiv.org
    The genome of the tardigrade Hypsibius dujardini
    1
    1. daveh70 02 Dec 2015
      We compare our assembly to a recently published one for the same species and do not find support for massive horizontal gene transfer. Additional analyses of the genome are ongoing.

      They are contradicting another study that claimed that a certain species of tardigrade had about 17.5 percent of its DNA borrowed from other organisms through horizontal gene transfer. http://www.sciencealert.com/the-tardigrade-genome-has-been-sequenced-and-it-has-the-most-foreign-dna-of-any-animal

      biology evolution
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    biorxiv.org/content/early/2015/12/01/033464
  198. Nov 2015
  199. courses.edx.org courses.edx.org
    Week 6 Summary | Review Section: Weeks 6 to 9 | GG101x Courseware | edX
    4
    4. bbarker 29 Nov 2015
      They have helped people reduce chronic pain, improve psoriasis, and increase their immune response to the flu shot. One study of mindfulness/compassion meditation out of Emory University showed reductions in stress markers, and even a simple long exhale (ahhhh) increases vagal tone. And – last but not least – a three-month meditation training program boosted telomerase activity, indicating longer telemores and perhaps a longer life expectancy.
      happiness mindfulness meditation health biology
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  200. courses.edx.org courses.edx.org
    Intro to Video: Play and the Pursuit of Happiness | Laughter, Play, and Narrative | GG101x Courseware | edX
    11
    1. bbarker 29 Nov 2015
      In one version of this experiment, if we gave participants synthetic oxytocin (in the nose, that will reach the brain in an hour), they donated to 57 percent more of the featured charities and donated 56 percent more money than participants given a placebo. Those who received oxytocin also reported more emotional transportation into the world depicted in the ad. Most importantly, these people said they were less likely to engage in the dangerous behaviors shown in the ads. So, go see a movie and laugh and cry. It’s good for your brain, and just might motivate you to make positive changes in your life and in others’ lives as well.
      happiness biology social empathy kindness charity story
    2. bbarker 29 Nov 2015
      When people watch Ben’s story in the lab—and they both maintain attention to the story and release oxytocin—nearly all of these individuals donate a portion of their earnings from the experiment. They do this even though they don’t have to. This is surprising since this payment is to compensate them for an hour of their time and two needle sticks in their arms to obtain blood from which we measure chemical changes that come from their brains. 

      (Ben's story is a very sad story)

      happiness history biology charity kindness empathy
    4. bbarker 23 Nov 2015
      As rats age, their chirping generally becomes less frequent. (A similar phenomenon seems to occur in humans: Research done by William Fry, a professor emeritus at Stanford University School of Medicine, has found that kindergarteners laugh 300 times a day, whereas adults laugh just 17 times.) However, rats who were tickled often when young usually retain their tendency to chirp later in life.
      happiness laughter biology ageing
    5. bbarker 23 Nov 2015
      It is precisely this more childlike, instinctive form of laughter that scientists believe they have uncovered in rats. Panksepp, the Baily Endowed Chair of Animal Well-Being Science at Washington State University, has found that rats emit their high-pitched chirps when tickled, especially in areas, such as the nape of the neck, that are targeted by fellow rats during playful bouts. They make the same sounds when playing or anticipating playtime with one another, as well as when anticipating a reward. Other research has found that this chirping is common when rats enter new environments or encounter new animals; Panksepp likens this to nervous laughter in humans.
      happiness laughter biology
    6. bbarker 23 Nov 2015
      scientists have probed the brain circuits involved in human laughter, but this research has faced a number of limitations. For one, though researchers have used sophisticated equipment to observe people’s brain activity while they read cartoons or jokes, this equipment is quite sensitive to movement—a major drawback when you’re trying to induce a hearty belly laugh.

      Why rats, which do have a form of ultrasonic laughter, have been used in laughter research.

      happiness laughter biology
    7. bbarker 22 Nov 2015
      Experiments on humans have found that laughter can increase blood flow and strengthen the heart, much like aerobic exercise does. Laughter also helps decrease one’s threshold for pain, although not all humor is the same in this respect. According to Weems, positive humor—humor that looks for the bright side of troubling situations—is beneficial to our health, while darker, sardonic humor is not.
      happiness laughter health biology
    8. bbarker 22 Nov 2015
      Take for example an old Groucho Marx joke: “One morning I shot an elephant in my pajamas. How he got in my pajamas, I don’t know.” Our brains will read the first sentence and be taken down a path imagining Grouch Marx on a safari in his pajamas, before we get the new image of the elephant actually inside his pajamas. That process of moving from one possible solution to the next involves a part of the brain called the anterior cingulate, or AC, which becomes more active when there are conflicting interpretations in the brain. The AC helps to quiet down the “louder” parts of the brain (associated with the expected response) to allow other quieter answers to emerge, and it’s particularly active during jokes. It helps us to figure out the novel solution, which, when resolved, gets incorporated into the brain and gives us that spike of dopamine. This is why we feel so good when we get a joke, and why jokes are not funny the second time around.
      happiness laughter biology
    9. bbarker 22 Nov 2015
      he grouped humor preferences into three types: “incongruity-resolution,” which involves “violating one’s expectations in novel ways;” “nonsense humor,” “which is funny only because it makes no sense;” and “sexual humor,” which is offensive or taboo. Although not everyone finds the same type of humor funny, the common thread in these joke types is that they all involve dealing with surprise and resolving the ensuing cognitive dissonance. “What elicits laughter isn’t the content of the joke but the way our brain works through the conflict the joke elicits,” writes Weems. Basic Books, 2014, 230 pages

      Apparently fMRI was used in this work, though it isn't immediately clear how.

      happiness laughter biology
    10. bbarker 22 Nov 2015
      Weems explains what humor is, how things become funny, and why evolution gave us laughter. According to Weems, laughter and humor help us process conflict in our environment through the dopamine that is released in our brains when we find something funny. Dopamine relieves tension—which I discovered with my son—but it’s also implicated in motivation, memory, and attention, affecting processes as varied as learning and pain management.
      happiness laughter biology evolution
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    courses.edx.org/courses/course-v1:BerkeleyX+GG101x+3T2015/courseware/9a813d84b92b4d06aecee1e76bb9b878/e1a0a39747f24217bf9d033491700ac4/
  201. courses.edx.org courses.edx.org
    Intro to Video: Introduction to Week 9 | The Cutting Edge: Awe, Wonder, and Beauty | GG101x Courseware | edX
    2
    1. bbarker 15 Nov 2015
      In answer to why awe would be a potent predictor of reduced pro-inflammatory cytokines, this latest study posits that “awe is associated with curiosity and a desire to explore, suggesting antithetical behavioral responses to those found during inflammation, where individuals typically withdraw from others in their environment,” Stellar said.
      happiness awe health biology
    2. bbarker 15 Nov 2015
      In addition to autoimmune diseases, elevated cytokines have been tied to depression. One recent study found that depressed patients had higher levels of the pro-inflammatory cytokine known as TNF-alpha than their non-depressed counterparts. It is believed that by signaling the brain to produce inflammatory molecules, cytokines can block key hormones and neurotransmitters—such as serotonin and dopamine—that control moods, appetite, sleep and memory.
      happiness awe health biology
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    courses.edx.org/courses/course-v1:BerkeleyX+GG101x+3T2015/courseware/9a813d84b92b4d06aecee1e76bb9b878/6487b5cef5f34495bdb1203bdd3a957b/