10,000 Matching Annotations
  1. Sep 2024
    1. Cena moved to California in 1998 to pursue a bodybuilding career and switched to professional wrestling in 1999, making his debut for Ultimate Pro Wrestling (UPW).

      ,

    1. At this time, residents of Barbour County were notorious for kidnapping and selling African Americans into bondage,

      So little of this history is erased by the United States and they replace this knowledge with enforcing the idea that slavery ended in 1865

    1. . He increased funding for the public school system, resulting in more rural schools and high schools in each county for white students and a rise in the state's literacy rate.

      It is interesting how his page starts and includes so many positive accomplishments. This seems to almost direct attention away from his negative actions and legacy.

    1. switch from carbohydrate metabolism to lipid metabolism for cellular energy supply.[30][31][32] This metabolic switch limits anaerobic metabolism and the formation of lactate, a herald of poor prognosis and multi-organ failure (MOF) after I/R injury. In addition, the increase in lipid metabolism generates ketone bodies and activates peroxisome proliferating-activated receptors (PPARs), both of which have been shown to be protective against I/R injury

      BOOM. KETO and KETO AS AGING TREATMENT.

    2. Superoxide dismutase edit Superoxide dismutase is an effective anti-oxidant enzyme which converts superoxide anions to water and hydrogen peroxide. Recent researches have shown significant therapeutic effects on pre-clinical models of reperfusion injury after ischemic stroke

      MITOCHONDRIA TREATMENT

    3. resulting in mitochondrial dysfunction and collapse. Upon collapse, the calcium is then released to overwhelm the next mitochondria in a cascading series of events that cause mitochondrial energy production supporting the cell to be reduced or stopped completely

      Wow.. Widespread mitochondrial death. This explains the need for necessary recovery period for mitochondria to be reproduced. Also makes clear an obvious mechanism why aerobic training, which increases mitochondria numbers, substantially increases aerobic endurance & speed, reduction in both ROS and Lactic Acidosis, thus pain, disease, and early death.

    4. brain ischemia/reperfusion injury is mediated via complex I redox-dependent inactivation.[5] It was found that lack of oxygen leads to conditions in which mitochondrial complex I loses its natural cofactor, flavin mononucleotide (FMN) and become inactive.[6] When oxygen is present the enzyme catalyzes a physiological reaction of NADH oxidation by ubiquinone, supplying electrons downstream of the respiratory chain (complexes III and IV). Ischemia leads to dramatic increase of succinate level.[7] In the presence of succinate mitochondria catalyze reverse electron transfer so that fraction of electrons from succinate is directed upstream to FMN of complex I.[8] Reverse electron transfer results in a reduction of complex I FMN, increased generation of ROS, followed by a loss of the reduced cofactor (FMNH2) and impairment of mitochondria energy production.[8]

      There's the observed metabolic "mitochondrial" disorder seen in LC

    1. upregulating SASP by induction of interferon type I.[

      IFN inactivates cells. Therefore viruses inactivate cells. CD4 T (helper) cells therefore love to inactivate cells. Cytokines therefore inactivate cells. Immune response cells thus inactivate cells. ROS, inflammation, hypoxia, therefore inactivate cells.

    1. Folklore 126 languages AfrikaansالعربيةAragonésঅসমীয়াAsturianuAvañe'ẽAzərbaycancaتۆرکجهBasa Baliবাংলা閩南語 / Bân-lâm-gúБеларускаяБеларуская (тарашкевіца)БългарскиBosanskiBrezhonegCatalàЧӑвашлаČeštinaChiShonaCymraegDanskDeutschދިވެހިބަސްEestiΕλληνικάЭрзяньEspañolEsperantoEuskaraفارسیFøroysktFrançaisFryskFurlanGaeilgeGaelgGagauzGalego한국어Հայերենहिन्दीHrvatskiIdoBahasa IndonesiaInterlinguaÍslenskaItalianoעבריתJawaქართულიKaszëbscziҚазақшаKernowekКомиKreyòl ayisyenKurdîКыргызчаLadinoLatinaLatviešuLietuviųLimburgsMagyarМакедонскиമലയാളംMaltiमराठीმარგალურიمصرىဘာသာမန်Bahasa MelayuМокшеньNederlandsनेपाली日本語NapulitanoНохчийнNorfuk / PitkernNorsk bokmålNorsk nynorskOccitanOromooOʻzbekcha / ўзбекчаਪੰਜਾਬੀپنجابیPapiamentuپښتوPolskiPortuguêsQaraqalpaqshaRomânăРусиньскыйРусскийScotsShqipSicilianuසිංහලSimple EnglishSlovenčinaکوردیСрпски / srpskiSrpskohrvatski / српскохрватскиSundaSuomiSvenskaTagalogதமிழ்Татарча / tatarçaతెలుగుไทยТоҷикӣTürkçeTyapУдмуртУкраїнськаاردوTiếng ViệtVõroWalonWinaray吴语ייִדיש粵語Žemaitėška中文 Edit links

      https://www.youtube.com/@braja573

    1. The law in many countries allows users certain rights over data whose copyright they do not own (including text, images, and other media), often under headings such as fair use or public interest. Depending on jurisdiction, these may cover issues such as whistleblowing, production of evidence in court, quoting or other small-scale usage, backups of owned media, and making a copy of owned material for personal use on other owned devices or systems. The steps implicit in trusted computing have the practical effect of preventing users exercising these legal rights.
    1. When the blood flow decreases so does the destruction of aldosterone by liver enzymes

      Micro thrombosis would cause aldosterone buildup....and liver dysfunction, eg ammonia buildup, blood toxins buildup, brain swelling and neurotoxic dysfunction

    1. Gilles Deleuze cites Eco's 1962 book The Open Work approvingly in his seminal 1968 text Difference and Repetition, a book which poststructuralist philosopher Jacques Derrida is said to have also taken inspiration from

      [[Difference and Repetition - Wikipedia]] v Gilles Deleuze refs The Open Work by Umberto Eco.

    1. Calling attention to the importance of "social forgetting", historian Guy Beiner has argued that "there is an evident need for major historical studies of lieux d’oubli to counterbalance the studies of lieux de mémoire."[11]

      What about the idea of "social ignorance" or maybe "social blindness" as American seems to have done with slavery in the post-Civil War to roughly the early 1990s?

    2. A lieu de mémoire (French for "site of memory" or memory space) is a physical place or object which acts as container of memory.[1] They are thus a form of memorialisation related to collective memory, stating that certain places, objects or events can have special significance related to group's remembrance.

      This feels like it's tangential to memory palaces, but I'll have to read more of Nora to discern if he had any experience here or if he's simply stumbled upon a related idea, but one which wasn't taken to it's logical extreme.

    1. Anti-folk (sometimes spelled antifolk) is a music genre that emerged in the 1980s in New York City, founded by musician, author and comedian, Lach, as a reaction to the commercialization of folk music. It is characterized by its DIY ethos, unconventional songwriting, and often humorous or satirical lyrics. Antifolk music was made to mock the perceived seriousness of the era's mainstream music scene,[1] and artists aim to protest with their mocking and clever lyrics.[2][3]

      Interesting how artist go back and forth between different styles to reject seriousness. im thinking of the Stiglitz Photo Succession movement, the Pictoralist, and Subjektive Fotografie.

    1. Multithreading is a widespread programming and execution model that allows multiple threads to exist within the context of one process. These threads share the process's resources, but are able to execute independently.
    1. Decimals are commonly used to approximate real numbers. By increasing the number of digits after the decimal separator, one can make the approximation errors as small as one wants, when one has a method for computing the new digits.
    1. For example, the bathroom scale may convert a measured extension of a spring into an estimate of the measurand, the mass of the person on the scale. The particular relationship between extension and mass is determined by the calibration of the scale.

      imperfect / not exact / not directly measured

    1. Round half to even, which rounds to the nearest even number. With this method, 1.25 is rounded down to 1.2. If this method applies to 1.35, then it is rounded up to 1.4. This is the method preferred by many scientific disciplines, because, for example, it avoids skewing the average value of a long list of values upwards.
    2. For example, if the length of a road is reported as 45600 m without information about the reporting or measurement resolution, then it is not clear if the road length is precisely measured as 45600 m or if it is a rough estimate.
    1. The town was heavily garrisoned by Union troops, and though the city was pro-union the surrounding areas of Boone County and the rest of central Missouri was decidedly pro-south.

      Incredible how this is still reflected in local politics, today.

    1. The complication comes from the fact that the execution model does not have any means for the execution of "give up ownership of the lock" to have any influence over which execution of "gain ownership of the lock" in some other timeline (thread) follows. Very often, only certain handoffs give valid results. Thus, the programmer must think of all possible combinations of one thread giving up a lock and another thread getting it next, and make sure their code only allows valid combinations.
    2. The execution model is the definition of the behavior, so all implementations, whether in-order or out-of-order or interpreted or JIT'd etc.. must all give the exact same result, and that result is defined by the execution model.
    1. "environments and tools for producing, curating, and interacting with knowledge that is 'born digital' and lives in various digital contexts."

      Digital humanities defined within the context of software creation.

  2. Aug 2024
    1. The term 'fashion' originates from the Latin word 'Facere,' which means 'to make,' and describes the manufacturing, mixing, and wearing of outfits adorned with specific cultural aesthetics, patterns

      fire

    1. Today, the site features two ancient steles, as well as groundwork and the bases of several pillars. The steles date to the Liao and Yuan dynasties, but their inscriptions were tampered with during the Ming. During the early 20th century, two stone blocks

      test

    1. The most popular majors at Syracuse University include: Communication, Journalism, and Related Programs; Social Sciences; Business, Management, Marketing, and Related Support Services; Visual and Performing Arts; and Engineering. The average freshman retention rate, an indicator of student satisfaction, is 91 percent.[115] The student-faculty ratio at Syracuse University is 15:1, and the school has 58.5 percent of its classes with fewer than 20 students.

      syracuse

    2. Coeducation at Syracuse traced its roots to the early days of Genesee College where educators and students like Frances Willard and Belva Lockwood were heavily influenced by the Women's movement in nearby Seneca Falls, NY. However, the progressive "co-ed" policies practiced at Genesee

      test

    1. Paris 2024 Paralympic Games, and branded as Paris 2024, is the 17th Summer Paralympic Games, an international multi-sport parasports event governed by the International Paralympic Committee, held in Paris, France, from 28 August to 8 September 2024.

      First summer Paralympic games in France.

    1. Wikipedia's purpose is to benefit readers by presenting information on all branches of knowledge. Hosted by the Wikimedia Foundation, it consists of freely editable content, whose articles also have numerous links to guide readers towards more information.

      annotation on wikipedia