60 Matching Annotations
  1. Apr 2024
    1. Research shows that groundwater levels are rapidly declining, especially in dry regions with extensive croplands, and has accelerated over the past four decades in 30% of the world's regional aquifers
  2. Jan 2024
    1. The navigation bar at the top of this webpage has clear contrast between the background and the foreground. This ensures that individuals experiencing limited vision will be able to navigate the website and tell the difference between the background and the foreground.

  3. Oct 2023
    1. Archives. The Member shall use best efforts to contract with a third-party archive or other content host (an "Archive") (a list of which can be found here) for such Archive to preserve the Member's Content and, in the event that the Member ceases to host the Member's Content, to make such Content available for persistent linking.


    2. Maintaining and Updating Metadata.


  4. Jul 2023
  5. bafybeihzua2lldmlutkxlie7jfppxheow6my62x2qmywif2wukoswo5hqi.ipfs.w3s.link bafybeihzua2lldmlutkxlie7jfppxheow6my62x2qmywif2wukoswo5hqi.ipfs.w3s.link
      • Title
        • Three levels of the symbolosphere
      • Authors
        • Mark Burgin and John H. Schumann
      • Abstract

        • This paper attempts to understand the coexistence of the
          • material and
          • non-material
        • aspects of our lives.
        • By synthesizing ideas about
          • structures,
          • physical entities,
          • mental phenomena, and
          • symbolic relations,
        • we argue that
          • the nonmaterial can emerge from the material, and
          • then the nonmaterial may mediate the production of material entities.
        • Finally, this cycle is applied to notions of creativity and invention.
      • Comment

        • the authors are situated in materialism that explains non-materialism as an epi-phenomena
  6. Jun 2023
    1. One) Successful men realize that the most important decision in their life is the woman they choose, because outside of work, this is what they'll be spending most time on. The woman must understand the man's grand ambition, and support them with it. (Cf. Flow & The Intellectual Life as well). Women should be chosen on personality, not looks. Looks fade (attraction as well), personality "stays".

      Two) Everyone deserves an opinion but not everyone deserves a say. Charlie Munger sums this up right: "I don't ever allow myself to have [express] an opinion about anything that I don't know the opponent side's argument better than they do." Or Marcus Aurelius, who says: "The opinion of ten thousand men is of no value if none of them know anything about the subject." In short: Only state your opinion when you can back it up!; knowledge and experience. The same goes for judging opinion (and advice) from others.

      Three) Successful people buy assets when the money is enough. Assets > Luxury. (See also: Rich Dad, Poor Dad, Robert Kiyosaki). Only buy glamor and other "interests" once your assets are there to secure your financial success.

      Four) Be pragmatic. Do what's practical, not what is "sexy". Notice inefficiencies and solve them. The entrepreneurial mindset.

      Five) The morning sets the tone for the rest of the days. Time is subjective, waking up early doesn't matter as much as waking up later. It depends on the person. Someone who wakes up at 10am can be as successful as someone who wakes up at 6am. Instead, what defines success, is a highly effective morning routine.

      Six) The less you talk, the more you listen. Talking less means less mistakes. In addition, the less you talk, the more people will listen when you do speak. It puts extra weight on your message. Listening means analysis and learning.

      Seven) Pick the right opportunity at the right time. Pick the right vehicle. Do the right things in the right order! The advice "don't do what someone says, do what they do" is bullshit, as you can't do what someone is able to do after ten years of experience.

      Eight) Discipline > Motivation. Motivation, like Dr. Sung says, fluctuates and is multifactorial dependent... When you are lead by motivation you will not be as productive. Don't rely on chance. Rely on what is stable.

      Nine) Once a good career has been made, buy A1 assets and hold on to them to secure a financially successful future.

      Ten) Just because you won, you are not a winner. Being a winner is a continuous process, it means always learning and reflecting as well as introspecting. Don't overvalue individual wins but do celebrate them when appropriate.

      Eleven) Build good relationships with the banks early on. At times you need loans to fund certain ventures, when having a good relation with them, this will be significantly easier. Understand finance as early as possible. Read finance books.

      Twelve) Keep the circle small. Acquintances can be many, but real close relationships should be kept small. Choose your friends wisely. "You become the average of the five people you spend most time with." Privacy is important. Only tell the most deep secrets to the Inner Circle, to avoid overcomplication.

      Thirteen) Assume that everything is your fault. Responsibility. It leads to learning. It requires reflection and introspection. It leads to Dr. Benjamin Hardy's statement: "Nothing happens to you, everything happens for you."

      Fourteen) Work like new money, but act like your old money. Combine the hunger of the new with the wisdom of the old.

      Fifteen) Assume that you can't change the world, but slightly influence it. It prevents disappointments and gives a right mindset. Do everything (that has your ambition) with an insane drive. Aim to hit the stars. To become the best of the best.

      Sixteen) Private victories lead to public victories. The solid maxim is the following: "The bigger the public victory, the more private victories went into it." Work in private. Social media doesn't need to known the struggle. Let your results talk for you. This is also why you should never compare yourself to others, but rather to your own past self.

      Seventeen) After extreme experience, the most complicated task will look elegant and effortless. Unconscious competence.

  7. May 2023
    1. ontology researchers have developed their own approaches to levels, which they call granularity levels, and to different types of hierarchies based on levels, which they call granular perspectives. Due to the need of computer-parsability, ontology researchers necessarily had to provide explicit criteria for identifying and demarcating different levels and hierarchies. These criteria specify what is called a granularity framework

      There is no consensus on the idea of levevls of science, hwo many numbers of levels and what constitutes the lowest levels etc. But big data, data exploreation and eScience demanded computer oarsability. That requires organizing knowledge and types of entities in unambigious hierarchies (of levels!) for comnputer based reasoning.

      levels -> becamse granularity levels different hierarchies based on levels -> granular perspectives criteria of identifying and demarcating levels -> granularity framework

  8. Mar 2023
    1. Review coordinated by Life Science Editors Foundation

      Reviewed by: Dr. Angela Andersen

      Potential Conflicts of Interest: None

      Background: * mRNAs in polarized cells often have a distinct spatial localization patterns that enable localized protein production * In non-polarized cells, mRNAs encoding membrane and secretory proteins are predominantly translated on the endoplasmic reticulum (ER), some mRNAs are enriched on the mitochondrial surface, some mRNAs are bound to the RNA-binding protein (RBP) TIS11B at the surface of the rough ER in "TIS granules". * The translation of specific mRNAs in TIS granules allows assembly of protein complexes that cannot be established when the mRNAs are translated on the ER but outside of TIS granules (physiological relevance). * The canonical rough ER (CRER) is distinct from the TIS granule ER (TGER), and both are distinct from the cytosol.

      Questions: * Do mRNAs that encode non-membrane proteins differentially localize to the ER or the cytosol? (in steady state) * Does the amount of protein synthesis differ depending on the subcytoplasmic location of an mRNA?

      Summary: * A third of mRNAs that encode non-membrane proteins have a biased localization to TGER or CRER, indicating that the ER membrane is a general site of translation for both membrane and non-membrane proteins. * 52% of mRNAs that encode non-membrane proteins have a biased mRNA transcript localization pattern towards a single cytoplasmic compartment. the TGER, CRER or cytosol. * The localization at the TGER or CRER was largely controlled by a combinatorial code of AU-RBPs at the 3'UTR. TIS11B promotes mRNA localization to TGER and TIA1/L1 to CRER. * LARP4B bound to the 3'UTR promotes cytosolic localization. * The location of translation has an independent effect on protein levels independent of the RBPs/3'UTR: redirecting cytosolic mRNAs to the rough ER membrane increased their steady-state protein levels by two-fold, indicating that the ER environment promotes protein expression. * Compartment-enriched mRNAs differed in their mRNA production and degradation rates, as well as functional classes and levels of their encoded proteins. Therefore the cytoplasm is partitioned into different functional and regulatory compartments that are not enclosed by membranes. * low-abundance proteins are translated in the TGER region. mRNAs encoding zinc finger proteins and transcription factors were substantially enriched at the TGER. These gene classes are usually expressed at lower levels than others.. This localization may regulate protein complex assembly (membrane proteins that are translated in the TGER domain establish protein complexes that cannot be formed when the proteins are translated on the CRER). The TGER may ensure that low-abundance mRNAs are effectively translated into low-abundance proteins. * mRNAs that are the most stable and encode the most highly expressed proteins are enriched on the CRER and include helicases, cytoskeleton-bound proteins, and chromatin regulators, overturning the idea that most non-membrane protein-encoding mRNAs are translated in the cytosol. * mRNAs overrepresented in the cytosol had the highest production and degradation rates and were enriched in proteins involved in mRNA processing and translation factors, whose abundance levels require tight control.

      Advance: Evidence for functional compartmentalization of non-membrane mRNA protein expression in the cytosol vs ER. In steady state, general localization of mRNAs to the ER promotes high protein levels.

      Significance: Engineered 3'UTR sequences could potentially boost protein expression by localizing mRNAs to the ER in experimental settings, for vaccines etc.

      Remaining questions/points: * How does the rough ER stimulate protein expression? * Does the mRNA localization affect complex formation and/or function of non-membrane proteins? * Does this occur in cells other than HEK293T? * Is this regulated?

  9. Jan 2023
    1. 个人学习可能取决于他人行为的主张突出了将学习环境视为一个涉及多个互动参与者的系统的重要性
  10. Dec 2022
    1. So we've got to establish our priorities. And then there's three levels if you will.

      !-- priorities : 3 levels - Short term (next few years) - medium term (next 5 to 10 years) - long term ( next 50 years)

  11. Oct 2022
    1. elaboration n. 1. the process of interpreting or embellishing information to be remembered or of relating it to other material already known and in memory. The levels-of-processing model of memory holds that the level of elaboration applied to information as it is processed affects both the length of time that it can be retained in memory and the ease with which it can be retrieved.
  12. Sep 2022
    1. maintenance rehearsal repeating items over and over to maintain them in short-term memory, as in repeating a telephone number until it has been dialed (see rehearsal). According to the levels-of-processing model of memory, maintenance rehearsal does not effectively promote long-term retention because it involves little elaboration of the information to be remembered. Also called rote rehearsal. See also phonological loop.

      The practice of repeating items as a means of attempting to place them into short-term memory is called maintenance rehearsal. Examples of this practice include repeating a new acquaintance's name or perhaps their phone number multiple times as a means of helping to remember it either for the short term or potentially the long term.

      Research on the levels-of processing model of memory indicates that maintenance rehearsal is not as effective at promoting long term memory as methods like elaborative rehearsal.

    1. your cognitive load increases with the level of indentation. 1 2 3 4 5 6 7 8 9 10 if r.Method == "GET" { if r.Header.Get("X-API-KEY") == key { // ok return nil }else{ return errors.New("Key is not valid") } } else { return errors.New("Invalid Method") }
    2. Avoid indentation levels, If you find yourself with more than 3, you should create a function.
  13. Jul 2022
  14. Mar 2022
    1. All the knowledge provided by Elders in this book has beenapproved for public eyes. Higher, secret levels of knowledge exist,but they are not presented here.
  15. Jan 2022
  16. Aug 2021
  17. Jul 2021
    1. Elisabeth Mahase. (2021, July 26). At least 6 weeks between Pfizer vaccine doses = higher neutralising antibody levels (than a 3-4 wk interval) For those with the delta variant, antibody levels were 2.3-fold higher with the longer interval Preprint from @pitchstudy @bmjlatest https://t.co/E3yOTqNgpa [Tweet]. @emahase. https://twitter.com/emahase_/status/1419604658344112130

  18. Jun 2021
    1. How to test at the correct level?
    2. As many things in life, deciding what to test at each level of testing is a trade-off:
    3. Unit tests are usually cheap, and you should consider them like the basement of your house
    4. A system test is often better than an integration test that is stubbing a lot of internals.
    5. Only test the happy path, but make sure to add a test case for any regression that couldn’t have been caught at lower levels with better tests (for example, if a regression is found, regression tests should be added at the lowest level possible).
    6. Black-box tests at the system level (aka end-to-end or QA tests)
  19. Apr 2021
  20. Mar 2021
  21. Feb 2021
  22. Oct 2020
  23. Sep 2020
    1. At this point, you start to engage your mind and dig into the work required to understand what’s being said. I highly recommend you use marginalia to converse with the author.

      From the linked article

      Full ownership of a book only comes when you have made it a part of yourself, and the best way to make yourself a part of it— which comes to the same thing— is by writing in it.

      Really love that quote - the idea of [[marginalia]] is to write in the margins, take notes as you read - to ask questions and answer them, and context around the highlights.

      In turn, [[make the book your own]]

    2. Analytical reading is a thorough reading. If inspectional reading is the best you can do quickly, this is the best reading you can do given time.

      [[analytical reading]] is one of the [[four levels of reading]] - the goal is to get to know a particular text very well.

    3. Systematic skimming

      sub-type of [[inspectional reading]] - reading the table of contents, skimming pages, looking for the hooks - how does this relate to [[proximity principle]] and [[scanning patterns]] - but getting a sense enough to know "is this book worth adding to the collection" for deeper reading

    4. Inspectional Reading We’ve been taught that skimming and superficial reading are bad for understanding. That is not necessarily the case. Using these tools effectively can increase understanding. Inspectional reading allows us to look at the author’s blueprint and evaluate the merits of a deeper reading experience.

      I think this is where I've been able to use #ADHD to it's advantages at times is with [[inspectional reading]] - being able to skim a large amount of content and get a sense of what I want to dig into later on or not.

  24. Aug 2020
    1. Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. M., Thouvenel, C., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., Fahning, M. L., Chen, Y., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L. P., Hamerman, J. A., King, N. P., … Pepper, M. (2020). Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. MedRxiv, 2020.08.11.20171843. https://doi.org/10.1101/2020.08.11.20171843

  25. Jul 2020
    1. Pollán, M., Pérez-Gómez, B., Pastor-Barriuso, R., Oteo, J., Hernán, M. A., Pérez-Olmeda, M., Sanmartín, J. L., Fernández-García, A., Cruz, I., Larrea, N. F. de, Molina, M., Rodríguez-Cabrera, F., Martín, M., Merino-Amador, P., Paniagua, J. L., Muñoz-Montalvo, J. F., Blanco, F., Yotti, R., Blanco, F., … Villa, A. V. de la. (2020). Prevalence of SARS-CoV-2 in Spain (ENE-COVID): A nationwide, population-based seroepidemiological study. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)31483-5

    1. Fontanet, A., Grant, R., Tondeur, L., Madec, Y., Grzelak, L., Cailleau, I., Ungeheuer, M.-N., Renaudat, C., Pellerin, S. F., Kuhmel, L., Staropoli, I., Anna, F., Charneau, P., Demeret, C., Bruel, T., Schwartz, O., & Hoen, B. (2020). SARS-CoV-2 infection in primary schools in northern France: A retrospective cohort study in an area of high transmission. MedRxiv, 2020.06.25.20140178. https://doi.org/10.1101/2020.06.25.20140178

    1. Fontanet, A., Tondeur, L., Madec, Y., Grant, R., Besombes, C., Jolly, N., Pellerin, S. F., Ungeheuer, M.-N., Cailleau, I., Kuhmel, L., Temmam, S., Huon, C., Chen, K.-Y., Crescenzo, B., Munier, S., Demeret, C., Grzelak, L., Staropoli, I., Bruel, T., … Hoen, B. (2020). Cluster of COVID-19 in northern France: A retrospective closed cohort study. MedRxiv, 2020.04.18.20071134. https://doi.org/10.1101/2020.04.18.20071134

  26. Jun 2020
    1. Long, Q.-X., Tang, X.-J., Shi, Q.-L., Li, Q., Deng, H.-J., Yuan, J., Hu, J.-L., Xu, W., Zhang, Y., Lv, F.-J., Su, K., Zhang, F., Gong, J., Wu, B., Liu, X.-M., Li, J.-J., Qiu, J.-F., Chen, J., & Huang, A.-L. (2020). Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature Medicine, 1–5. https://doi.org/10.1038/s41591-020-0965-6

  27. Nov 2019
    1. File-relative configuration Babel loads .babelrc (and .babelrc.js / .babelrc.cjs / package.json#babel) files by searching up the directory structure starting from the "filename" being compiled (limited by the caveats below). This can be powerful because it allows you to create independent configurations for subsections of a package. File-relative configurations are also merged over top of project-wide config values, making them potentially useful for specific overrides, though that can also be accomplished through "overrides".
  28. Aug 2019
    1. The cost of a single-payer system would depend upon its design, benefit levels, and scope of coverage.

      It is impossible to provide a specific costing method, but only general methods. How is design dependent? What is the benefit level of? and the range means the limit of the "Single-payer" system?

  29. Mar 2019
    1. Jack Phillips and ROI. This page describes the Phillips Return on Investment model. The model as presented here is an alternative to Kirkpatrick's model. There's a bulleted list of the components of the model as well as a nice graphic that briefly describes the levels. There is an explanation about how to apply the model, though I think more information would be needed for real world practice. Rating 4/5

    1. This is one of many discussions of Kirkpatrick's four levels of evaluation. More of the page is taken up with decoration and graphics than needs to be the case but this page is included in this list because it offers a printable guide and because the hierarchy of the four levels is clearly shown. The text itself is printed in black on a white background and it is presented as a bulleted list (the bullets are not organized as well as they could be). Nonetheless it is a usable presentation of this model. rating 3/5

  30. Oct 2018
  31. Aug 2018
    1. Patreon Engineering Levels

      Engineering focus, but a very detailed rubric of how to rank different personnel levels. Could maybe be generalized/adapted for other fields.