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  1. Aug 2024
  2. elifesciences.org elifesciences.org
    Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
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    elifesciences.org/content/4/e06434
  3. elifesciences.org elifesciences.org
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
    24
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    elifesciences.org/content/5/e17047
  4. elifesciences.org elifesciences.org
    Decoupling global biases and local interactions between cell biological variables
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    elifesciences.org/content/6/e22323
  5. Jul 2024
  6. elifesciences.org elifesciences.org
    Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting
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    elifesciences.org/articles/85521
  7. elifesciences.org elifesciences.org
    Ribozyme-catalysed RNA synthesis using triplet building blocks
    8
    1. isabellamaisonette 15 Jul 2024
      Yet, some RNA strands can also fold to form ribozymes, 3D structures that could have guided life’s chemical processes the way proteins do now.

      Ribosomes are made up of rRNA and proteins. I was unaware of this until this reading

    2. Nathan_P 12 Jul 2024
      Taken together, the interaction of triplet substrate pools with RNA templates promotes uncoupling of an RNA’s sequence (i.e. information content, and associated folding tendencies) from its replicability, thereby enhancing RNA’s capacity to serve as an informational polymer.

      i wonder what the effects of this would look like on a person compared to someone without triplet substrate pools

    3. Nathan_P 12 Jul 2024
      For instance, when binding templates, triplets incur a lower entropic cost per position compared to canonical mononucleotides (thus aiding copying of sequences rich in weakly pairing A and U bases),

      Dose this imply that cellular functioning such as the repairing damaged skin could effectively be done quicker with triplet substrates?

    4. Nathan_P 12 Jul 2024
      When RNA is copied, one strand acts as a template, and a replicase ribozyme would accurately guide which letters are added to the strand under construction.

      Similar to a chef making a recipe and someone at home following that recipe

    5. isabellamaisonette 11 Jul 2024
      iterative RNA-templated oligonucleotide ligation

      I was a bit confused by this term and found that it means synthesis of longer RNA sequences from shorter oligonucleotides which is guided by an RNA templet.

    6. isabellamaisonette 11 Jul 2024
      reciprocally synthesizing their own ‘+’ and ‘–’ strands

      From Biology LibreText: Positive-sense viral RNA is similar to mRNA and thus can be immediately translated by the host cell. Negative-sense viral RNA is complementary to mRNA and thus must be converted to positive-sense RNA by an RNA polymerase before translation.

      For some context about the information.

    8. isabellamaisonette 11 Jul 2024
      molecule must have had the ability to make copies of itself.

      RNA folding is a common process when RNA is synthesized. After researching the process is called cotranscriptional folding and is thought to impact gene expression and RNA function.

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    elifesciences.org/articles/35255
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier
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    ncbi.nlm.nih.gov/pmc/articles/PMC11090517/
  9. elifesciences.org elifesciences.org
    The yellow gene influences Drosophila male mating success through sex comb melanization
    5
    1. isabellamaisonette 07 Jul 2024
      How can sex comb melanization affect sex comb function? In insects, melanization impacts not only the color of the adult cuticle but also its mechanical stiffness

      Key point of why only 3% of y1 male fruit flies are able to mate.

    2. isabellamaisonette 05 Jul 2024
      yellow on male

      Just wanted to throw out that it may be important to study males due to the yellow gene being a sex-linked trait. Males will have a greater chance of inheriting the phenotype as they only require one X chromosome to display it.

    3. Nathan_P 04 Jul 2024
      The interaction between Yellow and dopamine might explain the protein’s effects on male mating success because dopamine acts as a modulator of male courtship drive in D. melanogaster (Zhang et al., 2016).

      Dose this mean a fly in a lab setting could mate less than a true wild fruit fly? (assuming lab flies produce less dopamine compared to their wild counterpart)

    4. Nathan_P 04 Jul 2024
      which was perceived as a behavioral defect for decades, is caused by changes in the morphology of the structures used during mating. Other recent studies have also shown the importance of morphological structures for stickleback schooling (Greenwood et al., 2015), water strider walking (Santos et al., 2017), and cricket singing (Pascoal et al., 2014) behaviors.

      Using this knowledge, I wonder if eye color could also effect the chances of mating in these fruit flies.

    5. Nathan_P 04 Jul 2024
      Video recordings of male flies with reduced yellow expression in dsx-expressing cells showed the same mating defect observed in y1 mutants: males seem to perform all courtship actions normally, but repeatedly failed to copulate (Video 5).

      This leads me to question if females mate more to visual cues rather than chemical cues.

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    elifesciences.org/articles/49388
  10. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
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    elifesciences.org/articles/98649
  11. Jun 2024
  12. elifesciences.org elifesciences.org
    The Natural History of Model Organisms: The secret lives of Drosophila flies
    11
    1. gbonet 28 Jun 2024
      For example, D. pachea is endemic to the Sonoran Desert of North America, where it depends on the sterols in the cactus Lophocereus schottii, which has alkaloids that other Drosophila species cannot tolerate. Because of its obligate association with its cactus host, it is exposed to temperatures that often approach 50°C. Such species provide unprecedented opportunities to understand the genetic bases of adaptations to extreme situations (see Box 1) and to recruit these species to address problems of species loss in the face of global warming and other anthropogenic changes.

      Interesting, kind of similar to how different species of mammals adapt to different environments and even take on adaptations necessary to survive in that environment. I think that studying evolutionary adaptations of these drosophila could help to combat species loss as it would give us insight towards generational survival.

    2. gbonet 28 Jun 2024
      D. melanogaster, described by Meigen in 1830, appears to have originated in sub-Saharan Africa (Lachaise et al., 1988). The first out-of-Africa habitat expansion of D. melanogaster is thought to have occurred between 10,000 and 15,000 years ago, when it moved to Europe and Asia

      Throughout my undergrad research, I have found that most species whos evolutionary history or point of origin is tracked usually comes out of africa and then moves into europe or north america. This the same for humans, and felids to my knowledge. However, Canids seem to have originated in Northeast Asia.

    3. isabellamaisonette 27 Jun 2024
      The genetic bases of these specializations, as they relate to phenomena such as the evolution of pesticide resistance (

      Does this mean pesticides are a human made product that impact insects in the same capacity as allelochmeicals and secondary metabolites?

    4. isabellamaisonette 27 Jun 2024
      human disease

      I didn't see any evidence pointing to the commonalities between human genes and fruit fly gene sequence, is this part of the reasoning why the species can be used for this purpose?

    5. isabellamaisonette 27 Jun 2024
      ales appear to sort themselves out by size at the mating site, with smaller males often being found in parts of the fruit where there are fewer females and thus fewer matings

      This is extremely interesting. I wonder what this means for the future of the species as it seems a greater concentration of larger males are mating with females. Are the mother's genetics what keep a variety of sizes present within a population?

    9. Nathan_P 27 Jun 2024
      Another product of anthropogenic change is the evolution of pesticide resistance in a wide range of insects of economic and medical importance.

      can this be used to reflect people's natural resistance to certain diseases?

    10. Nathan_P 27 Jun 2024
      What role can natural history play in our ability to understand these interactions with a view towards disease mitigation and treatment? In the past few decades, the importance of the gut microbiome for models of human health has grown.

      kinda surprising that they could use something as small as these flies to study gut microbes, I wonder what type of tools they use to study this.

    11. Nathan_P 27 Jun 2024
      It is not clear why or how he came to breed them, but their short generation time and ease of rearing were probably very appealing attributes.

      When it comes to model organisms, a short generation time is essential that way we can quickly see the results of potential crosses, another model organism that has a short generation time is the zebrafish

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    elifesciences.org/articles/06793
  13. elifesciences.org elifesciences.org
    Dynamics of venom composition across a complex life cycle
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    1. Nathan_P 26 Jun 2024
      ematostella vectensis suggests that venom is already expressed in eggs and larvae of this species.

      an example that this venom was not originally in the animal but was developed over a long period of time

    3. isabellamaisonette 26 Jun 2024
      by ectodermal gland cells

      This relates to gbonet's comment on spiders and the Cnidaria's evolutionary similarities. In an article I read, it pointed out that the epithelia of three major salivary glands may be of ectodermal origin, and spiders deliver venom from modified salivary glands.

    4. isabellamaisonette 26 Jun 2024
      A planula larva emerges from the egg package 48–72 hpf and starts swimming in the water

      I am a bit excited that I predicted this information after researching a bit of the first few sentences!

    5. isabellamaisonette 26 Jun 2024
      They then become swimming larvae, barely visible to the naked eye, that do not feed

      This interested me and I was wondering if these would be considered planula larvae? If so it is extremely interesting and I wonder when their mouth and digestive tract develop. I also learned a new term-- lecithotrophy. Which means that they feed on egg yolk and materials put in the egg by the mother (I would assume the ladder is not applicable since the sea anemones shoot out their sperm and eggs to reproduce there is not time for preparation of greater material).

    6. gbonet 25 Jun 2024
      The oldest extant group of venomous animals is the marine phylum Cnidaria, which includes sea anemones, corals, jellyfish and hydroids.

      I wonder when comparing the evolutionary tree of a Cnidaria species to the evolutionary tree of a snake, or spider, how similar would they be?

    7. gbonet 25 Jun 2024
      The starlet sea anemone, Nematostella vectensis, is becoming a leading cnidarian lab model as unlike many other cnidarian species it can be grown in the lab throughout its life cycle. This makes Nematostella a unique system to study the venom of an animal with a complex life cycle. Another advantage is that the high genetic homogeneity of the common Nematostella lab strain minimizes individual genetic variation, which is far from trivial in most other venomous animals collected from the wild in limited numbers.

      These are all valid reasons that support the claim that the Starlet Sea Anemone is a prime model organism for studying the venom of an animal with a complex life cycle.

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    elifesciences.org/articles/35014
  14. May 2024
  15. elifesciences.org elifesciences.org
    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
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    elifesciences.org/reviewed-preprints/86727v2
  16. elifesciences.org elifesciences.org
    CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
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    elifesciences.org/reviewed-preprints/90648v2
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Experience shapes chandelier cell function and structure in the visual cortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC10963032/
  18. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    46
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    elifesciences.org/articles/90683
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    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
    21
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    elifesciences.org/reviewed-preprints/92673
  20. elifesciences.org elifesciences.org
    Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function
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    elifesciences.org/articles/89424
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    Partitioning to ordered membrane domains regulates the kinetics of secretory traffic
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    elifesciences.org/reviewed-preprints/89306
  22. elifesciences.org elifesciences.org
    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
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    elifesciences.org/reviewed-preprints/84875
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    Mono-methylated histones control PARP-1 in chromatin and transcription
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    elifesciences.org/articles/91482
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact
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    ncbi.nlm.nih.gov/pmc/articles/PMC11065425/
  25. Apr 2024
  26. elifesciences.org elifesciences.org
    Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
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    elifesciences.org/reviewed-preprints/94917
  27. elifesciences.org elifesciences.org
    Convergent epigenetic evolution drives relapse in acute myeloid leukemia
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    elifesciences.org/articles/93019
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11003744/
  29. Mar 2024
  30. elifesciences.org elifesciences.org
    Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex
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    elifesciences.org/articles/82952
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    Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS
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    elifesciences.org/articles/83725
  32. elifesciences.org elifesciences.org
    Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS
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    elifesciences.org/articles/87592