24 Matching Annotations
  1. Feb 2022
    1. you can't see the beetle in my box nor I the one in yours ludwig wittgenstein use the beetle in the Box analogy to suggest that the meaning of sensation words such as pain isn't given 00:01:10 by referring to some private inner introspected something a sensation to which you alone have access in his view there can't be more to the public meaning of our language than we are capable of teaching each other and the 00:01:23 private something the beetle can't have a role in that teaching because we can't get at

      The duality of self and other is the peculiar symmetrical asymmetry of being human, and possibly of being life itself.

      Similarity and differences in the meaning of words between individuals is unavoidable because we all seem to share this quality of consciousness, as well as the quality of experiencing others as objects of our consciousness.

      Nature instills the quality of "unique conscious experience" to each of us. Biological replication is the basis for the repetition of this pattern in all members of our species.

      Why was I drawn to the content of this youtube, which came from this article interviewing Teodora Petkova: https://medium.com/content-conversations/a-semantic-text-strategy-conversation-teodora-petkova-fa6d8ad7c72f Through this youtube and through the interview with Teodora Petkova, I became aware of Ludwig Wittgenstein's beetle-in-a-box analogy for private thoughts.A meme is reproduced and shared over and over, drawing people who resonate with it.

      Hence, my own discovery of this idea demonstrates the mechanics of self and other consciosness. In any rendition of the present, my semantic state has been influenced by countless number of other writers, content developers or consciousnesses, echoing Husserl's Lebenswelt. Once we are bootstrapped into language through a long gestation period of child development, we simply grow our vocabulary of words, and continuously upgrade their individual meaning through the unique experiences of our unique lifeworlds.

      This symmetrical asymmetry is a distinct and unique property of the individual human, showing just how entangled the individual is with the collective, the self with the other.

      It is said that the most obvious is at the same time the most difficult to see. The metaphor "a fish does not know of the water that surrounds it" is apt. Our symmetrical asymmetry of experience is so universal that its salience and peculiarity is easily overlooked and not explicitly discussed except by the philosophically inclined. It is more often subconsciously felt than made into an explicit subject of discourse. It is recognized as obvious and coming with the territory of being human.

      Indeed, we might say that this common peculiarity of the private, subjective world is paradoxically one of the strangest and yet one of the most common at the same time. Its obviousness does not lessen its profound sense of magic.

      The fact that we live in these two kinds of worlds, the private inner and the public outer, and that these terms "private inner" and "public outer" are themselves abstractions, also explains how our participation in collective reality may often not live up to expectations.

      For example, in a time when the world needs to undergo a monumental whole system change, it is a challenge to mobilize sufficient number of people to drive the needed change. Part of the reason for this could be that the individual pole, the salience of the "private, inner" pole could prioritize it above even such collective action. The ideas and feelings in our own life as an individual, driven by our private inner lives may dominate our individual actions. Getting on with life often supersedes even threats to society.

  2. Jan 2022
  3. Nov 2021
    1. We are like someone who knows that a fever, a cough, and loss of smell are all symptoms of something, but has no idea about the virus that causes them.

      Metaphor to illustrate that we don't know the cause of depression.

    1. Each new layer of Life is the result of what scientists call a major evolutionary transition? What was the cause of these transitions the answer is? Cooperation a Major Transition starts when free living creatures team up to form a cooperative group in the early stages of cooperation Participants are free to come and go as they [please] [if] a group sticks together long enough however 00:04:51 Division of labor will often evolve different participants begin specializing in different tasks as time goes on Individuals may become so specialized that they can no longer survive on their own [if] the entire group becomes locked into cooperation Depending fully on one another to survive and reproduce a new super organism has been forged and they made your evolutionary transition is complete 00:05:16 From this point on the entire group will evolve together as one Models describing natural situations that might promote the evolution of major transitions have been put forth by scientists such as John Maynard Smith [fior] Sonck Mary stuart West and w d hamilton using these models Researchers have been able to Mimic natural scenarios in the lab Allowing us to directly witness the beginnings of major transitions [evolved]

      This is the key to Major Evolutionary Transition - a population of free living individual creatures discover that in teaming up, there is a greater resultant evolutionary fitness, mutualism symbiotic relationship emerges. It becomes so strong over time that the many become a self-replicating one.

      The biological self is always defined by a boundary between inner and outer, but in this act of mutualism, the many biological selves join to form a new higher order biological self.

      In this way, a multi-cellular species like ours is somewhat like one of those nested Russian dolls.

      Indeed, Amanda Robins hypothesizes


      that our species has undergone what she and Peter Nonacs calls Major System Transition (MST). The cultural artifact of inscribed language has made possible a superorganism / supraorganism that has spread across the globe.

  4. Oct 2021
  5. Sep 2021
  6. Jul 2020
  7. May 2020
  8. Apr 2020
  9. Mar 2020
    1. selected after transformation and used to inoculate liquid cultures

      Would the variability be the same if the colonies were picked from a streaked plate (from glycerol stock) instead of a transformation plate?

      I would expect the glycerol stock method to have more variability, but it would be good to test

  10. Oct 2019
    1. bioluminescence was observed during the incubation time between 90 and 150 min in the presence of a sole carbon source such as glucose, acetate, l-glutamate and BOD standard solution (GGA solution)

      So this is a limited BOD sensor for only the subset of organic compounds that E. coli can metabolize?

  11. Feb 2019
  12. Nov 2018
  13. Feb 2018
    1. Different sets of ESR1 polymorphisms were associated with cognitive decline from CDR 0 to 0.5 and CDR 0.5 to 1. ESR1 polymorphisms (rs3853248, rs22334693 [ESR1+397], rs9340799 [ESR1+351], rs9397456, rs1801132 [ESR1+975], rs2179922, rs932477, and rs9341016) were associated with the deterioration of episodic memory among subjects with baseline CDR 0, indicating these polymorphisms might be markers for episodic memory decline at an earlier stage
      p(HGNC:ESR1) hasVariant g(dbSNP:rs3853248)
      p(HGNC:ESR1) hasVariant g(dbSNP:rs22334693)
      p(HGNC:ESR1) hasVariant g(dbSNP:rs9340799)
      p(HGNC:ESR1) hasVariant g(dbSNP:rs9397456)
      p(HGNC:ESR1) hasVariant g(dbSNP:rs1801132)
      p(HGNC:ESR1) hasVariant g(dbSNP:rs2179922)
      p(HGNC:ESR1) hasVariant g(dbSNP:rs932477)
      p(HGNC:ESR1) hasVariant g(dbSNP:rs9341016)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs3853248)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs22334693)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9340799)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9397456)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs1801132)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs2179922)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs932477)
      a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9341016)
    1. Although we observed no association between rs3785883 or rs1868402 alone and change in CDR-sb (P > .10), there was a significant association between a combined genotype model and change in CDR-sb: carriers of the high-risk genotypes at both loci progressed >2.9 times faster than noncarriers (P = .015)
      g(dbSNP:rs1868402) cnc a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes")
      g(dbSNP:rs3785883) cnc a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes")
      composite(g(dbSNP:rs1868402),g(dbSNP:rs3785883)) pos a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes")
  14. Oct 2017
  15. Oct 2016
    1. blast

      BLAST finds regions of similarity between biological sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance.