Psychological symptoms of the outbreak of the COVID-19 crisis and confinement in the population of Spain

The addition of supraphysiologic doses of L-T4 (300 mcg per day) to an otherwise stable medication regimen of standard treatments resulted in a significant decline in depression scores during the 6-week, double-blind treatment phase. At endpoint (week 6), the mean HamD score showed a group difference of 3.7 points in favor of L-T4. Such difference is generally considered to be clinically meaningful in a short-term treatment trial for major depression. NICE used a 3.0-point difference in HamD change scores as a criterion of clinical significance.27

L-thyroxine at an average dose of 350 micro g/die. Outcomes were moderate in 39.3% and very good in 21.5%, corresponding to 21-item HAMD scores of < or =16 and < or =8 and clinical judgement. Of all patients, 39.3% had to stop treatment due to nonresponse or side effects.

RESULTS: Two patients dropped out of the study owing to side effects. The remaining 7 patients received a final mean dose of T4 of 235 +/- 58 micrograms/day (range: 150-300 micrograms/day). Their scores on the Hamilton Depression Rating Scale had fallen from a mean of 21.1 +/- 4.1 before inclusion in the study to a mean of 8.0 +/- 2.8 at the end of the 8th week. Five patients were full responders, 1 a partial responder, and 1 a nonresponder.CONCLUSIONS: Augmentation with high-dose T4 proved to have an antidepressant effect in more than 50% of the previously treatment-resistant patients with chronic depression and/or dysthymia.

Thyroxine was added to their antidepressant medication, and the doses were increased to a mean of 482 ± 72 μg/day.

This isshown by a number of studies that link cyberbul-lying to depression, school problems, low self-esteem and even self-harm (Price and Dalgleish,2010;ˇSl ́eglov ́a andˇCern ́a, 2011; Vandebosch etal., 2006).

Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use.

His clinical experience led him to develop the theory of positive disintegration (TPD), which posits that, far from being destructive and undesirable, many forms of psychological suffering—anxiety, depression, doubts, inner conflicts, even psychosis—are positive and necessary for emotional and personality development. More often than not, they are expressive of the emerging understanding of the multilevel nature of reality, inner and external, and, related, an objectively existing hierarchy of human values. This understanding becomes a basis of personality growth through positive disintegration

Nobody can “treat” a war, or abuse, rape, molestation, or any other horrendous event, for that matter; what has happened cannot be undone. But what can be dealt with are the imprints of the trauma on body, mind, and soul: the crushing sensations in your chest that you may label as anxiety or depression; the fear of losing control; always being on alert for danger or rejection; the self-loathing; the nightmares and flashbacks; the fog that keeps you from staying on task and from engaging fully in what you are doing; being unable to fully open your heart to another human being.

The hurdle we face today is not lack of skill, it's depression

I made the library, and these initial zines, as a personal act to get out of a depression

In this test, endogenous depressives showed a significantly reduced HGH response to clonidine as compared to normal controls, neurotic-reactive depressives, and schizophrenics. However, no differences were found between the endogenous depressives and a group of schizoaffective patients.

One group received citalopram (up to 60 mg/day) plus vitamin C (up to 1,000 mg/day). The other group received citalopram plus placebo.

Gender socialization can direct some men to withhold or restrict emotional expression, leaving men with limited ways to express their feelings of emotional pain and psychological distress.

“Think of all the things that could interfere with graduating from college.” Then he instructs them to pick one of those items and to come up with as many solutions for that problem as possible. This is a classic divergent-convergent creativity challenge. A subset of respondents, like the proverbial Murphy, quickly list every imaginable way things can go wrong. But they demonstrate a complete lack of flexibility in finding creative solutions. It’s this inability to conceive of alternative approaches that leads to despair. Runco’s two questions predict suicide ideation—even when controlling for preexisting levels of depression and anxiety.In Runco’s subsequent research, those who do better in both problem-finding and problem-solving have better relationships. They are more able to handle stress and overcome the bumps life throws in their way. A similar study of 1,500 middle schoolers found that those high in creative self-efficacy had more confidence about their future and ability to succeed. They were sure that their ability to come up with alternatives would aid them, no matter what problems would arise.

“Do you not see the reason for yourself,” he indifferently replied.

God works mysteriously. God is like a great attraction without a marquee or a billboard. God is pulling you along incessantly. Hopefully, the excess baggage in your life will be left aside sufficiently so that you can begin to experience the attraction itself, for this is the call of love to the lover. This is what you try to recreate with one another, this profound love and attraction.

My solution to the problem posed by the incompatibility of depression and social media didn’t aim to change anyone’s life but my own. Yet maybe it was no less radical: Ruthlessly dispose of all fake intimacy and superficial interactions and focus what little energy I had on real connection. Take my feeble attention span and put it into the equivalent of an incubator. Learn to consider myself a worthy human being without the positive reinforcement of Twitter favs.

Professor Heuser thought for a moment. “That’s only indirectly related to social media,” she finally said. “People suffering from depression are incredibly creative at convincing themselves they are losers. But we live in a world that’s hyper-communicative — not really communicative, but narcissistic. Everybody is always ‘sharing’ something, only that it isn’t really sharing, it’s posting something to a wall in the hope that as many people as possible will come past and ‘like’ it. The purpose is to feed our narcissism. It is a many-voiced monologue, a cacophony. Everybody is posting something, but we aren’t talking to each other.”

However, the positive feeling that usually follows — your organism can’t mount that response anymore. That’s a classic symptom of depression. You can’t feel joy or connection to others anymore.” And because my brain knows what joy used to feel like, she explained, its absence, that emptiness, is experienced subconsciously as painful. The fact that I found it so hard to resist the lure of said dopamine release was also easy to explain, she said: “Will has to do with energy. And depression is characterised precisely by a lack of energy.”

the very simple finding is that the peoplewho laughed when talking about the relationship with their partners two and four years laterwere actually doing a lot better psychologically. Less anxiety, greater purpose in life, greaterrelationships with other people, less depression by finding perspective through laughter.

Mauss shows that the more people strive for happiness, the more likely they will be to set a high standard for happiness—then be disappointed when that standard is not met.  This is especially true when people were in positive contexts, such as listening to an upbeat song or watching a positive film clip. It is as if the harder one tries to experience happiness, the more difficult it is to actually feel happy, even in otherwise pleasant situations. My colleagues and I are are building on this research, which suggests that the pursuit of happiness is also associated with serious mental health problems, such as depression and bipolar disorder. It may be that striving for happiness is actually driving some of us crazy.

In the present study, the impact of PC on the activity and feedback regulation of the hypothalamic-pituitary-adrenal axis (HPA) impaired in depression has been studied in the model of shock-induced depression in rats.