90 Matching Annotations
  1. Nov 2024
    1. Disease: N/A, variant present in F12 gene

      Patient: 36 yo, Female, Saudi descent

      Variant:F12 NC_000005.9:g.176,830,269 G>A; p.Gly506Asp Homozygous mutation, exon 12 Located in peptidase S1 domain of F12

      Family:

      Consanguineous family history (parents first-degree cousins)

      No family history of bleeding or thrombosis

      Phenotypes:

      Significantly high activated partial thromboplastin time

      No history of bleeding during deliveries or tooth extractions

      No history of thrombosis or skin manifestations

      On no medications, physical examination unremarkable

      Factor assays and VWF tests within normal ranges except Factor XII (Severely deficient)

      variant is proposed to be deleterious but there is insufficient evidence to support this claim.

  2. Sep 2024
    1. Our patient

      Patient phenotypes listed: mild bleeding history normal platelet number increased mean platelet volume increased RIPA (les than typical PT-VWD) enhanced binding of VWF to platelets (assessed by flow cytometry)

      Has functional and HXMS data to support classification to pathogenic

    1. Don't assume that because you opened up a pull request, that the author will accept it. There are many reasons that a maintainer might choose to not merge in your specific patch, many of which have nothing to do with you. If your patch isn't accepted, try to assume it's for a valid technical reason and not because the author hates you.
  3. Aug 2024
    1. for example our standard english language model is trained with something like maybe 100 gigabytes or so of text um that gives it a strength as if you would throw bird at it with the google corpus so the other thing is of course uh a small corpus like that is computed in two hours or three hours on a on a laptop yeah so that's the other thing uh by the way i didn't mention our fingerprints are actually a boolean so when we when we train as i said we are not using floating points

      for - comparison - cortical io vs normal AI - training dataset size and time

    2. we basically grow models of let's say same quality like all the others by using thousand time or ten thousand times less training data

      for - comparison - semantic folding vs normal machine learning - training dataset sizes and times

  4. Jul 2024
    1. what we're looking at is developing these really these seawater farming units that can turn this land into into sea water farms 00:16:15 will be grow these these crops

      for - seawater farming - replacing normal agriculture in Bangladesh flood plain

  5. Mar 2024
    1. In 1938 and 1939, the Order Police expanded rapidly as theincreasing threat of war gave prospective recruits a furtherinducement. If they enlisted in the Order Police, the new youngpolicemen were exempted from conscription into the army.
  6. Feb 2024
    1. Lettersand photographs, and the effort to archive them, indicated the ex-tent to which soldiers deliberately placed themselves in world his-tory and adopted for themselves the heroicizing vantage of theThird Reich
    2. In time of war and separation, the letters to andfrom soldiers serving on the front lines were precious signs of life.They were avowals of love and longings for home. They describedthe battlefield and conditions of military occupation and eventuallyprovided historians with crucial documents about popular attitudestoward the war and knowledge about the Holocaust.
    3. One Berliner “watched his fellow passengers as he trav-eled past the burning Fasenenstrasse synagogue between the S-Bahnstations Savignyplatz and Zoologischer Garten the next morning:‘only a few looked up to see out the window, shrugged their shoul-ders, and went back to their paper.
    4. Setapart from the familiar social contexts of family, work, and school,the closed camp was designed to break down identifications withsocial milieus and to promote Entbürgerlichung (purging bourgeoiselements) and Verkameradshaftung (comradeship) as part of theprocess of Volkwerdung, “the making of the people,” as the pecu-liar idiom of National Socialism put it.

      entbürgerlichung - purging bourgeois elements

      verkameradshaftung - comradeship

      volkwerdung - the making of the people

    5. Criticism of the disruption of publicorder was widespread, but should not be taken completely at facevalue. It undoubtedly veiled deeper moral objections that were oth-erwise difficult to articulate in Nazi Germany
    6. most Germans welcomed legis-lation clarifying the position of Jews and hoped it would bring to anend the graffiti and broken windows of anti-Jewish hooliganism.
    7. “What am I going to do?” won-dered Richard Tesch, an owner of a bakery in Ballendstedt’s mar-ketplace: “Israel has been buying goods from me for a long time.Am I supposed to no longer sell to him? And if I do it anyway, thenI’ve lost the other customers.
    8. Neighbors in Wedding who remarkedthat “the Jews haven’t done anything to us” despised antisemitismbut upheld the separation between “us” and “them” at which itaimed.85 Custom and habit gave way to self-conscious and inhib-ited interactions structured by the unambiguous knowledge of race
    9. The startling events of the spring of 1933, when more andmore Germans realized that they were not supposed to shop inJewish stores and when German companies felt compelled to fireJewish employees and remove Jewish businessmen from corporateboards, moved Germany quite some distance toward the ultimategoal of “Aryanizing” the German economy.
    10. Public humiliations such as these depended on bystanders willing totake part in the spectacle. They accelerated the division of neigh-borhoods into “us” and “them.
    11. As thousands of new converts joined the para-military units of the SA, whose numbers shot up ninefold from500,000 in January 1933 to 4.5 million one year later, the scale ofantisemitic actions expanded dramatically. Becoming a Nazi meanttrying to become an antisemite as well.
    12. The idea of normality had become racialized, so that entitlement tolife and prosperity was limited to healthy Aryans, while newly iden-tified ethnic aliens such as Jews and Gypsies, who before 1933had been ordinary German citizens, and newly identified biologicalaliens such as genetically unfit individuals and so-called “asocials”were pushed outside the people’s community and threatened withisolation, incarceration, and death.
    13. one of the key purposes of popu-lar entertainment in the Third Reich: the creation of a commonlyshared culture to define Germans to one another and mark themoff from others.
    14. s aresult, Victor Klemperer could repeatedly “run into” one of Hitler’sReichstag speeches. “I could not get away from it for an hour. Firstfrom an open shop, then in the bank, then from a shop again.”66Radio as well as film turned Nazism into spectacle.
    15. Tacked onto the doorways of apartments, posters, labels, and badgesattested to the fact that nearly all residents belonged to the People’sWelfare or contributed to Winter Relief.

      signaling you belonged, if you didnt participate you were probably suspected of being a subversive

    16. Millions of people acquired new vocabularies, joined Nazi organi-zations, and struggled to become better National Socialists. Whatthe diaries and letters report on is not simply the large numberof conversions among friends and relatives but the individual en-deavor to become a Nazi.
    17. Young people don’t walk anymore; they march.” “Ev-erywhere friends are professing themselves for Hitler.” To livein Nazi Germany, Ebermayer wrote, was to “become ever morelonely.”
    18. “Hei hatte sagt, wer non ganz un gar nichwolle, vor dän in Deutschland keine Raum”—“he said there is noroom in Germany for people who simply refuse to take part.”
    19. Hermann Aue “(very Left),” thoughtthe Nazis would be gone within a year, so he was inclined to stickwith the Social Democrats. But several Communists who had re-portedly joined a local SA group suspected that the Nazis would bearound for some time.
    20. The fact is that it is totally possible,” he carefully noted,“that the National Socialist state would use such a law to make it aduty for those without means and who are dependent on handoutsfrom the state to more or less ‘voluntarily’ take their lives.
    21. The euthanasia “actions” anticipated the Holocaust. Figuringout by trial and error the various stages of the killing process, fromthe identification of patients to the arrangement of special trans-ports to the murder sites to the killings by gas in special chambersto the disposal of the bodies, and mobilizing medical experts whoworked in secret with a variety of misleading euphemisms to con-ceal their work
    22. ventuallythe criminal charges that relatives threatened to bring against hos-pitals, the dismay of local townspeople who wondered why the pa-tients “are never seen again”—“in one south German village, peas-ant women refused to sell cherries to nurses from the local statehospital”—and finally, in August 1941, the open denunciation ofinvoluntary euthanasia by Clemens August von Galen, the Catholicbishop of Münster in Westphalia, prompted Hitler to order the spe-cial killing centers dismantled.
    23. In Berchtesgarden, in southern Germany, schoolteachers an-notated the tables of ancestors prepared by schoolchildren andhanded them over to public-health officials
    24. Most candidates for sterilization came from lower-classbackgrounds, and since it was educated middle-class men who weremaking normative judgments about decent behavior, they were bothmore vulnerable to state action and less likely to arouse sympathy
    25. The rou-tine intervention of the police in the corners of daily life of Germancitizens explains why the Gestapo assumed the “almost mythicalstatus as an all-seeing, all-knowing” creature that had placed itsagents throughout the land to overhear conversations in order toenforce political conformity
    26. Did shesympathize a little bit with people who were not considered wor-thy? Perhaps so, because Gisela recalled the incident in postwar in-terviews; but other Germans continued to improve themselves bygrooming themselves as Aryans, sitting up straighter, filling out thetable of ancestors, and fitting in at the camps, which gave legiti-macy to the selection process that had created Gisela’s anxiety inthe first place
    27. With the massive expansion of the Hitler Youthto include girls as well as boys, more than 765,000 young peoplehad the opportunity to serve in leadership roles. Many advancedin the ranks and received formal training and ideological instruc-tion in national academies such as the Reich Leadership School inPotsdam.
    28. The Ministry of Education authorized the National So-cialist Teachers’ League to organize retraining camps in order to“equip,” as Rust put it, teachers with lesson plans in “heredity andrace”; an estimated 215,000 of Germany’s 300,000 teachers at-tended two-week retreats at fifty-six regional sites and two nationalcenters that mixed athletics, military exercises, and instruction.
    29. Arbeitsdienstmänner worked together as a unit, marched toget-her, and relaxed together, an unending group existence designed topull together the people’s community.
    30. We have to go with the times, even if thereare many, many things that we do not agree with. To swim againstthe current just makes matters worse.”
    31. More thana third of the 1938 graduating class of the Athenaeum Gymnasiumin the north German city of Stade hoped to pursue a career as an of-ficer in the Wehrmacht or a youth leader in the Hitler Youth
    32. The consciousness of generation, and the assumption thatold needed to be replaced with new, undoubtedly opened youngminds to the tenets of racial hygiene, which were repeatedly parsedin workshops and lectures.
    33. Boththe Hitler Youth and the Reich Labor Service aimed to mix bour-geois and working-class youths in order to pull down social barriersto the formation of national race consciousness.
    34. Enrollment for four years in theHitler Youth and then six months in the Reich Labor Service wasmade mandatory for boys in 1936 and for girls three years later
    35. Filled with photographs, graphs, and tables, thepropaganda of the Office for Racial Politics made the crucial dis-tinction between quantity and quality—Zahl und Güte—easy tounderstand. Unlike Streicher’s vulgar antisemitic newspaper, DerStürmer, the Neues Volk appeared to be objective, a sobering state-ment of the difficult facts of life

      hiding behind objectivity. ppl saying things and being like well its just fact w/o the ability to double check

    36. By the middle of 1937 the Office of Racial Politics hadtrained over 2,000 “racial educators,” who on the basis of an eight-week course in Berlin received a special speaker’s certificate enti-tling them to address Germans on population and race policy. Certi-fication was part of the effort to make German racism objective
    37. vast network of Gemeinschaftslager or com-munity camps was established across Germany; at one point or an-other, most Germans passed through them. Alongside concentra-tion camps and killing camps, the training camps were fundamentalparts of the Nazi racial project.

      gemeinschaftslager - community / training camps to educate germans on racial ideology

    38. In November in Weimar, he promised that “if to-day there are still people in Germany who say: ‘We are not goingjoin your community, but stay just as we always have been,’ then Isay: ‘You will die off, but after you there will a young generationthat doesn’t know anything else!’”

      brah

    39. But it also made demands on ordinary Germans, who neededto visualize the Volk as a vital racial subject, to choose appropriatemarriage partners, and to accept “limits to empathy.”
    40. he Germanpopulation was being resorted according to supposed genetic val-ues, a project that required all Germans to reexamine their rela-tives, friends, and neighbors.
    41. The journalistSebastian Haffner noted that people in his circle in Berlin suddenlyfelt authorized to express an opinion on the “Jewish question,”speaking fluently about quotas on Jews, percentages of Jews, anddegrees of Jewish influence
    42. Race defined the new realities of the ThirdReich for both beneficiaries and victims—it influenced how youconsulted a doctor, whom you talked to, and where you shopped.
  7. Sep 2023
    1. We should only write on one side of these papers so that in searching through them, we do not have to take out a paper in order to read it. This doubles the space, but not entirely (since we would not write on both sides of all the slips). This consideration is not unimportant as the arrangement of boxes can, after some decades, become so large that it cannot be easily be used from one’s chair. In order to counteract this tendency, I recommend taking normal paper and not card stock.
  8. Dec 2022
    1. Perrow argued that “normal accidents” were nearly inevitable in a complex, tightly coupled system. To resist such an outcome, systems designers needed to have backups and redundancy, safety checks and maintenance.
    2. One interesting concept in organizational sociology is “normal accidents theory.” Studying Three Mile Island, Charles Perrow created a 2x2 grid
  9. Oct 2022
  10. Aug 2022
  11. Apr 2022
    1. Another Angry Woman. (2022, January 1). A reminder that sometimes “living with it” means taking some mitigations, forever, e.g. How in order to live with cholera we make sure our water doesn’t have shit in it by building infrastructure to make sure our water doesn’t have shit in it. [Tweet]. @stavvers. https://twitter.com/stavvers/status/1477362596097536018

    1. Lawrence Gostin. (2022, January 1). History shows most pandemics last 2-3 years. Covid-19 has been a wily foe #NewYear2022 should see the pandemic’s end in highly vaccinated nations. Strive mightily to access vaccines everywhere But Covid-19 will remain endemic everywhere. The new normal means living with the virus [Tweet]. @LawrenceGostin. https://twitter.com/LawrenceGostin/status/1477087584459370507

  12. Mar 2022
  13. Oct 2021
  14. Mar 2021
  15. Nov 2020
  16. Aug 2020
  17. Jun 2020
  18. May 2020
  19. Apr 2020
    1. The appeal of the first of these options is that it has a clear rationale and an end-point when the virus has passed and life can return to normal.

      But what is "normal"?

  20. Mar 2020
  21. Dec 2019
  22. Nov 2017
    1. The most common eye finding in congenital toxoplasmosis is the presence of chorioretinal scars, reported in 79% of patients. These scars may occur anywhere in the retina but with a higher incidence in the macula.

      Ocular findings in Congenital Toxoplasomsis:

      • 79% patients have chorioretinal scars *Scar may involve macula with significant decrease in visual acuity
      • scar may involve periheral area with decreased acuity by dragging of macula

      Normal Retina

      Chorioretinal scar in congenital toxoplasmosis

      Other posterior ocular complications include:

      • retinal attachment and active chorioretinitis in 10%
      • Optic atrophy in 20%
      • Other findings may include: cataracts, microphtalmia, microcornea, nystagmus.
  23. May 2017
    1. Canol Pipeline
      Designed during the first months of World War II, the Canol Pipeline brought oil from Norman Wells near the Mackenzie River to Whitehorse, Yukon Territory. Once the oil was refined, it would be sent to Alaska via pipeline to ensure that the Japanese navy could not intercept any transport. The oil deposits at Norman Wells were discovered by the explorer Alexander Mackenzie during the 18th century. In January of 1942, Lieutenant General Brehon Somervell, commanding general of the Army Service Forces, ordered James H. Graham, former dean of engineering at the University of Kentucky, to investigate the possibility of harvesting oil from Norman Wells. On April 29, 1942, General Somervell immediately approved the recommendation of Dean Graham to implement a pipeline from Norman Wells to Whitehorse (O'Brien, 1970). The construction began in 1942 and was completed in 1944 by the United States Army. A road was also constructed alongside the Canol pipeline during this time. In 1945, soon after the completion of the Canol Pipeline, the volume of crude oil that was able to be transported compared to the cost of operating the pipeline could not be justified. The Canol Pipeline was shut down and abandoned in 1945 (Wilson, 1991). 
      

      References

      O'Brien, C. F. (1970). The Canol Project: A Study in Emergency Military Planning. The Pacific Northwest Quarterly, 101-108.

      Wilson, W. H. (1991). Review: A Walk on teh Canol Road: Exploring the First Major Northern Pipeline. The Pacific Northwest Quarterly, 114.

  24. Mar 2017
    1. bedetermined

      In some ways this feels a little too close to the saying "there is no normal." Conversely, because of my interests in disabilities studies, this gets a little too close to the belief that "we are all disabled." How closely does this proposal align with those (verging on banal) mottos?

  25. Jan 2017
    1. An anomaly is thus a mere difference in degree for which the norm will serve as metric.

      Normal is a powerful, potent, and potentially pernicious black box. And it is frequently a black box deployed against rhetoric.

    2. In his view, the ‘normal’ is the state that institutes the ‘norm,’ and the ‘normative’ as such is a prototypical condition

      Canguilhem also, in Knowledge of Life, notes that humans are unique in their ability to shelter and compensate for the anormal in their society. This further lessens the impact of natural selection in determining the normal and emphasizes how normativity is constructed by the norm.

      Canguilhem's basis for this is also pretty interesting. Medicine is the one science that has "good" and "bad" as measurements. He defines health as "a capacity to tolerate variations in norms...The measure of health is a certain capacity to overcome organic crises and to establish a new physiological order, different from the old" ("The Normal and the Pathological" loc 2627)

  26. Jun 2016
  27. screen.oxfordjournals.org screen.oxfordjournals.org
    1. a scientific programme, the founding act is on an equal footingI with its future transformations: it is merely one among the manymodifications that it makes possible. This interdependence cantake several forms. In the future development of a science, thefounding act may appear as little more than a single instance of amore general phenomenon that has been discovered. It might bequestioned, in retrospect, for being too intuitive or empirical andsubmitted to the rigours of new theoretical operations in order tosituate it in a formal domain. Finally, it might be thought a hastygeneralization whose validity should be restricted. In other words,the founding act of a science can always be rechannelled through' the machinery of transformations it has instituted.

      Paradigm shifts are part of the science that follows (i.e. are filled in by normal science, in Kuhn's terms).

    2. The distinctive contribution of these authors is that they pro-duced not only their own work, but the possibility and the rulesof formation of other texts. In this sense, their role differs entirelyfrom that of a novelist, for example, who is basically never morethan the author of his own text. Freud is not simply the author ofThe Interpretation of Dreams or of Wit and its Relation to theUnconscious and Marx is not simply the author of the CommunistManifesto or Capital: they both established the endless possibilityof discourse. Obviously, an easy objection can be made. The authorof a novel may be responsible for more than his own text; if heacquires some 'importance' in the literary world, his influence canhave significant ramifications. To take a very simple example, onecould say that Ann Radcliffe did not simply write The Mysteriesof Udolpho and a few other novels, but also made possible theappearance of Gothic Romances at the beginning of the nine-teenth century. To this extent, her function as an author exceedsthe limits of her work. However, this objection can be answeredby the fact that the possibilities disclosed by the initiators of dis-cursive practices (using the examples of Marx and Freud, whomI believe to be the first and the most important) are significantlydifferent from those suggested by novelists. The novels of AnnRadcliffe put into circulation a certain number of resemblances andanalogies patterned on her work - various characteristic signs,figures, relationships, and structures that could be integrated intoother books. In short, to say that Ann Radcliffe created the GothicRomance means that there are certain elements common to herworks and to the nineteenth-century Gothic romance: the heroineruined by her own innocence, the secret fortress that functions as

      Really useful passage to compare to Kuhn. This is basically an argument about paradigm shifters and normal science as applied to literature.