44 Matching Annotations
  1. Aug 2021
    1. it undergoes first-pass hepatic metabolism, resulting in low (30%–40%) bioavailability.

      I'll need to review this later. This is a more precise figure than I was familiar with. I think I read somewhere between 20% and 50%; I believe I cited that figure in one of my college papers.

  2. Jul 2021
  3. Jun 2021
    1. This way I'm able to pass cookie back and forth, so this code kind of works:
    2. 'set-cookie': response.headers.get('set-cookie')
    3. If you do need to passthrough your mydomain.com cookies to a thirdparty.com domain, you can technically already do that now by implementing it as an endpoint and calling fetch('/my-endpoint')
    4. I don't really want to re-implement all of my api endpoints to make this work. Is there a way to "mask" the thirdparty endpoints to pass through the cookies?
  4. Jan 2021
    1. allow <slot> to be part of a slot
    2. I want to make some add-ons or wrappers on components e.g BigButton.svelte <script> import Button from './Button.svelte' </script> <Button fz="16" h="64" {...$$props}> <slot slot="prepend" name="prepend" /> <slot /> <slot slot="append" name="append" /> </Button>
    3. Related to #1824, can do <svelte:component this={Bar}> <slot></slot> <slot name="header" slot="header"></slot> </svelte:component> <script> import Bar from './Bar.svelte'; </script> as a forwarding workaround
    1. In 3.29.0 you can now use <slot slot='...'> to forward slots into a child component, without adding DOM elements.
    2. Would love to see passthrough slots to create superset components, for example Table and TableWithPagination (table slots for TableWithPagination could be passed through to Table).
  5. Nov 2020
    1. All standard UI events are forwarded on components, input events ("input" and "change") are forwarded on input components, and all MDC events are forwarded.
    2. You can add props to lower components and elements with things like input$maxlength="15".
    3. You can add actions to the components with use={[Action1, [Action2, action2Props], Action3]}.
  6. Oct 2020
  7. Sep 2020
    1. We should also allow passing unrecognised props to the rendered component. eg: tabindex might be required on some instances of a component, and not all. Why should developers have to add tabindex support to their components just that it may potentially be used

      Glad to hear this is solved now: $restProps

    2. You could do something like this instead while maintaining complete control of where different props go. <div class="wrapper> <div {...$$props} > ... </div> </div>
  8. Aug 2020
    1. All of the components should allow passing MUI configuration properties to them so that they can be easily customized. In the case of RFF and MUI components with deeply nested structures of multiple subcomponents, you can pass the properties in with sepecial top level properties. This is very hard to document fully without making a mess, so please refer to the source code and demos for examples.
  9. May 2020
  10. Mar 2020
    1. 3,000 people have passed away as a result of the infection.

      "pass away" is a euphemism usually reserved for obituary pages. Victims of a virulent virus do not "pass away." They die.

  11. Dec 2019
    1. The only thing interesting in $1 tier is Edison's Concrete Piano, which I already have from previous bundle.

  12. Nov 2019
  13. Apr 2019
    1. Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases. The three forms of Klotho protein have distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of Pi and vitamin D metabolism. Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection. The intracellular form of Klotho suppresses inflammation-mediated cellular senescence and mineral metabolism. Herein we provide a brief overview of the structure and function and recent research about Klotho.
  14. Nov 2018
    1. By 2007, SHM had launched Project BOOST (Better Outcomes by Optimizing Safe Transitions), an award-winning mentored-implementation program to reduce LOS, adverse events, and unnecessary 30-day readmissions. Other mentored-implementation programs followed. The Glycemic Control Mentored Implementation (GCMI) program focuses on preventing hypoglycemia, while the Venous Thromboembolism Prevention Collaborative (VTE PC) seeks to give practical assistance on how to reduce blood clots via a VTE prevention program

      Other SHM Mentored Implementation programs -

      • Atul Gawande
      • I-PASS
      • PFC I-PASS Link this to
      • Dissemination and implementation of research findings
      • Twenty years since to err is human