8 Matching Annotations
  1. May 2020
  2. Mar 2020
    1. 3,000 people have passed away as a result of the infection.

      "pass away" is a euphemism usually reserved for obituary pages. Victims of a virulent virus do not "pass away." They die.

  3. Dec 2019
    1. The only thing interesting in $1 tier is Edison's Concrete Piano, which I already have from previous bundle.

  4. Nov 2019
  5. Apr 2019
    1. Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases. The three forms of Klotho protein have distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of Pi and vitamin D metabolism. Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection. The intracellular form of Klotho suppresses inflammation-mediated cellular senescence and mineral metabolism. Herein we provide a brief overview of the structure and function and recent research about Klotho.
  6. Nov 2018
    1. By 2007, SHM had launched Project BOOST (Better Outcomes by Optimizing Safe Transitions), an award-winning mentored-implementation program to reduce LOS, adverse events, and unnecessary 30-day readmissions. Other mentored-implementation programs followed. The Glycemic Control Mentored Implementation (GCMI) program focuses on preventing hypoglycemia, while the Venous Thromboembolism Prevention Collaborative (VTE PC) seeks to give practical assistance on how to reduce blood clots via a VTE prevention program

      Other SHM Mentored Implementation programs -

      • Atul Gawande
      • I-PASS
      • PFC I-PASS Link this to
      • Dissemination and implementation of research findings
      • Twenty years since to err is human