241 Matching Annotations
  1. Aug 2024
  2. Jun 2024
  3. May 2024
    1. Temperaturdaten aus der Messung von Baumringen zeigen, dass der Sommer 2023 in den nicht tropischen Gebieten der Nordhalbkugel eindeutig der heißeste Sommer seit mindestens 2000 Jahren war. Einer neuen Studie von forschenden um Jan esper zu Folge lagen die Temperaturen um 2 Grad über dem vorindustriellen Mittel, nicht nur, wie vom europäischen Wetterdienst Kopernikus publiziert, um 1,5 Grad https://www.derstandard.at/story/3000000219984/schnellster-co2-anstieg-in-der-luft-seit-50000-jahren

    1. Shell plant nicht mehr, seine Öl-Produktion bis 2030 wenigstens um 1-2% pro Jahr zu reduzieren. Zwischen 2023 und 2035 will die Firma jährlich 40 Milliarden Dollar in die Öl-und Gasproduktion und 10-15 Milliarden in „Low-Carbon“-Produkte investieren. Die Ölproduktion soll bis 2030 stabil bleiben, die Gasproduktion ansteigen. Shell beruft sich auch darauf, dass man 2021 die Anteile an einem Projekt im Permian Basin verkauft und damit die Ölproduktion früher als geplant bereits gedrosselt habe. https://www.theguardian.com/business/2023/jun/14/shell-drops-target-to-cut-oil-production-as-ceo-guns-for-higher-profits

    1. Shell will die Emissionsintensität seiner Öl-Produkte bis 2030 nur noch um 15-20% statt bisher um 20% reduzieren. Das verfässerte Ziele ist in der jüngsten Version der Energiewende-Strategie des Konzerns enthalten, die einen Teil des Jahresberichts 2023 bildet. Für Gas wurden keine Angaben gemacht. Auch für die absolute Höhe der Emissionen gibt der Fossilkonzern kein Ziel an. Durch neue Projekte wird Shell seine Öl- und Gasproduktion bis 2025 um 500.000 Barrel täglich steigern.

      https://www.theguardian.com/business/2024/mar/14/shell-warns-it-may-slow-emissions-reduction-during-crucial-climate-decade

    1. In der taz formuliert Sara Schurma 7 Schritte zu einer adäquaten Klimaberichterstattung:

      1. Kontext liefern
      2. Klima immer und überall mitdenken
      3. Strukturelle Probleme anerkennen
      4. Redaktionen mehr Fachwissen ermöglichen
      5. Verzögerungsnarrative einordnen
      6. „False Baance“ vermeiden
      7. Lösungen kritisch mitberichten

      Ihr Artikel gehört zu einem „Schwerpunkt Klima und Medien“. https://taz.de/7-Schritte-fuer-Redaktionen/!5956911/

  4. Apr 2024
    1. Eine neue Studie beschäftigt sich mit der zunehmenden Frequenz der Aufeinanderfolge extremer Trockenheit und extremer Niederschläge in Pakistan und in vielen afrikanischen Ländern. Ähnliche Phänomene lassen sich in Norditalien feststellen. https://www.theguardian.com/environment/2023/nov/14/extreme-drought-in-northern-italy-mirrors-climate-in-ethiopia

      Studie: https://washmatters.wateraid.org/sites/g/files/jkxoof256/files/2022-10/WaterAid%20Africa%20Drought%20work%20Methods%20and%20Full%20Results_CONFIDENTIAL_26_10_22_final%20%281%29.pdf

  5. Mar 2024
    1. Der italienische Energiekonzern Eni will bis 2027 27 Mrd. Euro investieren. Priorität habe dabei die Erhöhung der Rendite. In erneuerbare Energien werde investiert, wenn sie profitable Geschäfte versprächen. Die Originalquelle zeigt: Es wird massiv in die Exploration von Öl-und Gasfeldern und eine Ausweitung der fossilen Produktion investiert, die 2030 ihren Höchststend erreichen soll. https://www.repubblica.it/economia/finanza/2024/03/14/news/eni_il_dividendo_sale_a_1_euro_per_azione_nel_piano_al_2027_investimenti_per_27_miliardi-422310817/

      Eni-Strategie 2024-2027: https://www.eni.com/it-IT/investitori/strategia/piano-strategico.html

  6. Feb 2024
    1. Ausführlicher Bericht über die neue Studie zum Zustand des Amazonas-Regenwalds. Bis 2050 drohen 10-47% einen Kipppunkt zu erreichen, jenseits dessen sie ihre jetzigen Funktionen für Kohlenstoff- und Wasser Zyklen verloren. Die Studie beschäftigt sich mit 5 Treibern für Wasser-Stress. Um den Regenwald sicher zu erhalten, ist der Verzicht auf jede weitere Entwaldung und das Einhalten der 1,5°-Grenze nötig. https://www.theguardian.com/environment/2024/feb/14/amazon-rainforest-could-reach-tipping-point-by-2050-scientists-warn

  7. Jan 2024
    1. Edelmann PR hat 2022 intensiv mit der Charles Koch Foundation zusammengearbeitet. Edelmann PR, der weltgrößte PR-Konzerne, hatte sich wiederholt verpflichtet, Klimaneugnung nicht zu unterstützen. Die Koch-Brüder, ein wichtiger Teil der amerikanischen Fossilindustrie förderten und fördern seit Jahrzehnten Klimarleugnung. Es gibt Hinweise auf weitere Verbindungen von Edelman zu Koch Industries. https://www.theguardian.com/us-news/2024/jan/14/edelman-charles-koch-foundation-climate

  8. Dec 2023
  9. Nov 2023
    1. Hitzebedingte Todesfälle bei über 65-Jährigen haben seit den 90ern um 85% zugenommen. Senior:innen sind – wie kleine Kinder – zweimal soviel Hitzewellen-Tagen ausgesetzt wie 1986-2005. Extreme Hitze führte 2022 zu Produktivitätsverlusten von ca. 863 Milliarden USD. Alle Indikatoren für öffentliche Gesundheit haben sich in den letzten 9 Jahren verschlechtert. – Die NYT stellt den 2023 Report des Lancet Countdown ausführlich dar. https://www.nytimes.com/2023/11/14/climate/climate-change-health-effects-lancet.html

      Mehr zum Rreport: https://hypothes.is/search?q=tag%3A%222023%20report%20of%20the%20Lancet%20Countdown%20on%20health%20and%20climate%20change%22

    1. Vor der Apec-Konferenz haben China und die USA "statements of cooperation" veröffentlicht, die als positive Signale für eine Zusammenarbeit beim Klimaschutz gewertet werden, auch wenn China nicht auf Investitionen in Kohlekraftwerke verzichtet. Beide Seiten wollen die Kapazität bei Erneuerbaren bis 2030 global verdreifachen. Erstmals ist China bereits, Reduktionsziele für alle Treibhausgase festzulegen. https://www.nytimes.com/2023/11/14/climate/us-china-climate-agreement.html

      Sunnylands Statement on Enhancing Cooperation to Address the Climate Crisis: https://www.state.gov/sunnylands-statement-on-enhancing-cooperation-to-address-the-climate-crisis/

    1. behaviorist approach

      If your school using PBIS, it is very much based on behaviorism

    2. 14. Incentives

      Incentives = rewards?

  10. Oct 2023
    1. https://en.wikipedia.org/wiki/Shmita

      During shmita, the land is left to lie fallow and all agricultural activity, including plowing, planting, pruning and harvesting, is forbidden by halakha (Jewish law).

      The sabbath year (shmita; Hebrew: שמיטה, literally "release"), also called the sabbatical year or shǝvi'it (שביעית‎, literally "seventh"), or "Sabbath of The Land", is the seventh year of the seven-year agricultural cycle mandated by the Torah in the Land of Israel and is observed in Judaism.

    1. There are several occasions where the massebah is not associated with pagan worship. When the massebah is associated with the worship of Yahweh, the massebah is accepted as a valid expression of commitment to Yahweh.

      Massebah for pagan worship: - Exodus 23:24 (https://hypothes.is/a/r3m5QmyDEe6SC8eLYcJE1Q) - Hosea 10:1 (https://hypothes.is/a/4PK2GGyDEe6wZg_r2YpVCA ) - 2 Kings 18:4 - 2 Kings 23:14

      Massebah for worship of Yahweh: - Genesis 28:18 Jacob's pillow (https://hypothes.is/a/NF5p8Gx6Ee65Rg_J4tfaMQ)<br /> - Genesis 31:44-45 Jacob and Laban's covenant - Exodus 24:4 - Joshua 24:25-27

    2. in violation of the demands of the covenant, the people of Israel erected sacred stones dedicated to other gods (Hosea 10:1). In their religious reforms, both Hezekiah (2 Kings 18:4) and Josiah (2 Kings 23:14) destroyed the sacred pillars which the people of Israel had dedicated to the worship of Baal.
    3. During the establishment of the covenant between Yahweh and Israel, the people were commanded to destroy the sacred stones of the Canaanites, “You must demolish them and break their sacred stones (masseboth) to pieces” (Exodus 23:24).

      In neighboring cultures in which both have oral practices relating to massebah, one is not just destroying "sacred stones" to stamp out their religion, but it's also destroying their culture and cultural memory as well as likely their laws and other valuable memories for the function of their society.

      View this in light also of the people of Israel keeping their own sacred stones (Hosea 10:1) as well as the destruction of pillars dedicated to Baal in 2 Kings 18:4 and 2 Kings 23:14.

      (Link and) Compare this to the British fencing off the land in Australia and thereby destroying Songlines and access to them and the impact this had on Indigenous Australians.

      It's also somewhat similar to the colonialization activity of stamping out of Indigenous Americans and First Nations' language in North America, though the decimation of their language wasn't viewed in as reciprocal way as it might be viewed now. (Did colonizers of the time know about the tremendous damage of language destruction, or was it just a power over function?)

    4. Saul used a large stone to build an altar to Yahweh (1 Samuel 14:35).
    1. Ein Panel von Experten spricht sich in einem Bericht nachdrücklich für ein Moratorium für Geo-Engineering-Maßnahmen aus, die das Klima manipulieren sollen, Die vom früheren WTO-Chef Pascal Lamy geleitetete Climate Overshoot Commission stellt fest, dass die Wirkungen und Risiken solcher Maßnahmen bei weitem nicht ausreichend erforscht sind. https://www.theguardian.com/environment/2023/sep/14/experts-call-for-global-moratorium-on-efforts-to-geoengineer-climate

      Report der Climate overshoot Commission: https://www.overshootcommission.org/report

    1. Das europäische Parlament hat neue Grenzwerte für die Emissionen von Flugbenzin beschlossen. Eine Anpassung an die strengeren Werte der Weltgesundheitsorganisation soll auf Druck von Kritiker:innen im Parlament erst 2030-35 erfolgen. 2050 sollen 70% der Flugzeugtreibstoffe in der EU „nachhaltig“ sein. https://www.repubblica.it/green-and-blue/2023/09/14/news/ue_limiti_inquinamento_aria_biocarburanti_aerei-414423165/

  11. Sep 2023
    1. Spiral Dynamics (SD) is a model of the evolutionary development of individuals, organizations, and societies. It was initially developed by Don Edward Beck and Christopher Cowan based on the emergent cyclical theory of Clare W. Graves, combined with memetics as proposed by Richard Dawkins and further developed by Mihaly Csikszentmihalyi.

      https://en.wikipedia.org/wiki/Spiral_Dynamics

      related to ideas I've had with respect to Werner R. Loewenstein?

    1. https://lacountylibrary.libnet.info/event/9097350

      https://www.youtube.com/watch?v=xMF37TXAV5w

      Presenter Lawrence Mak broke down types of notes into the following three categories:<br /> - general notes (projects, ideas, journals, recipes, budgeting, homework, etc.)<br /> - lists (groceries, reading, gifts, to dos, assignments) - reminders (birthdays, bills, maintenance, health)

  12. Jul 2023
  13. Jan 2023
    1. Samson, last of the Judges, who kills thelion and obtains honey from its corpse, attaches burning torches to the tailsof foxes, and carries the heavy gates of Gaza upon his shoulders

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    Annotators

  14. Sep 2022
    1. Tutubox installation guide for iPhone and iPad Method 1 – install Tutubox directly to the device As the first step, you need to clear the cache and history in your Safari browser by navigating to the Safari settings.Now you need to go to the general settings and make sure that there are no certificates available in the certificate list.Then go to Wi-Fi settings and then you need to click configure the proxy. Under the configure proxy you need to paste this URL http://ffapple.com in the automatic field. Turn off Wi-Fi for about 10 seconds and enable it again and check if your proxy is still enabled, if not just go and enable it.The next step is to get the latest Tutubox version to your iDevice. You can use the official Tutubox website (tutubox.io). Visit this website from your Safari browser and then download Tutubx iOS for your device and install it.When the installation process is done, you need to go to Settings, General, Device manager, and then click the certificate and trust it. If you do not do this step, you will get a notification when you are trying to open Tutubox that says the term Untrusted Enterprise Developer.Now you have successfully installed the Tutubox latest version on your iPhone or iPad. You are good to go with installing apps, games, and other tools with Tutubox.

      Get Tutubox iOS 16 for installing the latest tweaks for iPhones and iPad for free

    1. Artykuł przedstawia historię idei Memeksu, autorstwa Vannevara Busha. Autor przedstawia także informacje na temat różnych wydań jego tekstu na ten temat.

      W tekście znajdują się także informacje na temat maszyny Rapid Selector, autorstwa Ralpha R. Shawa, powstałej na tym, co pisał Emmanuel Goldberg, który z kolei inspirował się pracą Busha.

  15. Aug 2022
  16. Jun 2022
  17. www.intendance03.fr www.intendance03.fr
    1. L'autorité académique peut-elle suspendre l'application d'une délibération du conseil d'administration d'un EPLE ? Non, l'article L.421-14 du code de l'éducation prévoit que l'autorité académique peut prononcer l'annulation des actes des EPLE relatifs au contenu ou à l'organisation de l'action éducatrice. En revanche, dans une décision du 26 octobre 2007, le tribunal administratif de Grenoble rappelle que « le pouvoir de suspension de ces actes n'est pas prévu expressément par les dispositions [...] du code de l'éducation »
  18. May 2022
    1. DICER1 syndrome encompasses a variety of benign and malignant manifestations including multinodular goitre

      Gene: DICER1 PMCID: PMC8451242 PMID: 34552563 Pathogenic Inheritance Pattern: Autosomal Dominant MultipleDiseaseEntities Disease Entity: DICER1 syndrome, multinodular goitre, cystic nephroma, anaplastic renal sarcoma, Wilms tumour, differentiated thyroid carcinoma, gynandroblastoma, ciliary body medulloepithelioma, embryonal rhabdomyosarcoma, pineoblastoma, pituitary blastoma, kidney cyst, pulmonary cyst, Sertoli-Leydig Cell Tumor. Mutation: Germline MultipleGeneVariants Variant & Clinvar IDs: c.3452_3453del (485534), c.316del (no ClinVar ID), c.171_172insAC (no ClinVar ID), c.3434del (no ClinVar ID), c.988C>T (933007), c.5388dup (no ClinVar ID) Zygosity: None provided. Case: At time of operation, the goitre patients living in Denmark were ages 21, 12, 21, 8, 14, and 16. Four underwent total thyroidectomies, and two underwent partial thyroidectomies. The patient originally aged 21 previously had a kidney cyst at age 14 and a pulmonary cyst at an unknown age. The patient aged 14 at time of partial thyroidectomy later manifested a Sertoli-Leydig Cell Tumor at age 15. All six patients were female. CasePresentingHPO: None provided. CasePreviousTesting: thyroidectomy gnomAD: ENSG00000100697.10, https://gnomad.broadinstitute.org/gene/ENSG00000100697 Mutation Type: Frameshift, Nonsense

  19. Mar 2022
  20. Jul 2021
    1. Zebrafish: Tg(kdrl:GFP)s843

      DOI: 10.1016/j.celrep.2019.05.052

      Resource: (ZFIN Cat# ZDB-ALT-050916-14,RRID:ZFIN_ZDB-ALT-050916-14)

      Curator: @ethanbadger

      SciCrunch record: RRID:ZFIN_ZDB-ALT-050916-14


      What is this?

    1. ZDB-ALT-070427-14

      DOI: 10.1523/ENEURO.0286-16.2017

      Resource: (ZFIN Cat# ZDB-ALT-070427-14,RRID:ZFIN_ZDB-ALT-070427-14)

      Curator: @evieth

      SciCrunch record: RRID:ZFIN_ZDB-ALT-070427-14


      What is this?

    2. ZDB-ALT-070427-14

      DOI: 10.1523/ENEURO.0286-16.2017

      Resource: (ZFIN Cat# ZDB-ALT-070427-14,RRID:ZFIN_ZDB-ALT-070427-14)

      Curator: @Naa003

      SciCrunch record: RRID:ZFIN_ZDB-ALT-070427-14

      Curator comments: Allele Name: Hu2098 Danio Rerio ZFIN Cat# ZDB-ALT-070427-14


      What is this?

    1. ZDB-ALT-070427-14

      DOI: 10.1016/j.neuron.2017.06.001

      Resource: (ZFIN Cat# ZDB-ALT-070427-14,RRID:ZFIN_ZDB-ALT-070427-14)

      Curator: @Zeljana_Babic

      SciCrunch record: RRID:ZFIN_ZDB-ALT-070427-14


      What is this?

    2. ZDB-ALT-170522-14

      DOI: 10.1016/j.neuron.2017.06.001

      Resource: (ZFIN Cat# ZDB-ALT-170522-14,RRID:ZFIN_ZDB-ALT-170522-14)

      Curator: @Zeljana_Babic

      SciCrunch record: RRID:ZFIN_ZDB-ALT-170522-14


      What is this?

  21. Jun 2021
  22. Apr 2021
    1. La composition ainsi que les missions et modalités de pilotage des comités d'éducation à la santé et à la citoyenneté sont détaillées dans la circulaire n°2016-114 du 10 août 2016.
  23. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 7.2

      AssayResultAssertion: Normal

      StandardErrorMean: 0.01

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.1250C>A p.(Ser417Tyr)

    1. SUPPLEMENTARY DATA

      AssayResult: 41

      AssayResultAssertion: Indeterminate

      PValue: < 0.0001

      Approximation: Exact assay result value not reported; value estimated from Figure 6C.

    2. SUPPLEMENTARY DATA

      AssayResult: -31

      AssayResultAssertion: Abnormal

      PValue: < 0.0001

    3. SUPPLEMENTARY DATA

      AssayResult: 82.22

      AssayResultAssertion: Indeterminate

      PValue: 0.004

      Comment: Exact values reported in Table S3.

    4. To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).

      HGVS: NM_024675.3:c.2840T>C p.(Leu947Ser)

    1. Source Data

      AssayResult: 117.58

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardErrorMean: 0.81

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 95.02

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardDeviation: 0.08

      StandardErrorMean: 0.06

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.1676A>G p.(Q559R)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 0.9

      AssayResultAssertion: Abnormal

      ReplicateCount: 12

      StandardErrorMean: 0.6

      Comment: This variant had loss of function of peak current (<10% of wildtype), therefore it was considered abnormal (in vitro features consistent with Brugada Syndrome Type 1). (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.2204C>A p.(Ala735Glu)

  24. Feb 2021
    1. RRID:ZDB-ALT-131122-14

      DOI: 10.7554/eLife.54491

      Resource: (ZFIN Cat# ZDB-ALT-131122-14,RRID:ZFIN_ZDB-ALT-131122-14)

      Curator: @scibot

      SciCrunch record: RRID:ZFIN_ZDB-ALT-131122-14


      What is this?

    1. Supplemental material

      AssayResult: 91

      AssayResultAssertion: Normal

      Comment: See Table S2 for details

    2. Supplemental material

      AssayResult: 4.9

      AssayResultAssertion: Abnormal

      Comment: See Table S2 for details

    3. We analysed a total of 82 blood samples derived from 77 individuals (online supplemental table 3). These 77 individuals corresponded either to new index cases suspected to harbour a pathogenic TP53 variant or to relatives of index cases harbouring TP53 variants.

      HGVS: NM_000546.5:c.323G>A p.(Gly108Asp)